MCID: NRG002
MIFTS: 54

Neurogenic Bladder malady

Neuronal, Nephrological categories

Summaries for Neurogenic Bladder

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64Wikipedia, 33MalaCards
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Wikipedia:64 Neurogenic bladder dysfunction, sometimes simply referred to as neurogenic bladder, is a dysfunction of... more...

MalaCards: Neurogenic Bladder, also known as neurogenic dysfunction of the urinary bladder, is related to vesicoureteral reflux and urinary tract obstruction. An important gene associated with Neurogenic Bladder is P2RX2 (purinergic receptor P2X, ligand-gated ion channel, 2), and among its related pathways are Muscarinic acetylcholine receptors and Class A/1 (Rhodopsin-like receptors). The drugs hyoscyamine sulfate and baclofen and the compounds n methylscopolamine and 5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and kidney, and related mouse phenotypes are respiratory system and nervous system.

Aliases & Classifications for Neurogenic Bladder

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Nephrological


Aliases & Descriptions:

neurogenic bladder 8 10
neurogenic dysfunction of the urinary bladder 8
neurogenic urinary bladder disorder 8
neurogenic urinary bladder 61
neurogenic bladder nos 8
neuropathic bladder 8
bladder neurogenic 45


External Ids:

Disease Ontology8 DOID:12143
NCIt40 C79696
ICD9CM27 596.54
MeSH35 D001750

Related Diseases for Neurogenic Bladder

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Neurogenic Bladder:



Diseases related to neurogenic bladder

Clinical Features for Neurogenic Bladder

Drugs & Therapeutics for Neurogenic Bladder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Neurogenic Bladder

Drug clinical trials:

Search ClinicalTrials for Neurogenic Bladder

Search NIH Clinical Center for Neurogenic Bladder

Search CenterWatch for Neurogenic Bladder

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Neurogenic Bladder

Anatomical Context for Neurogenic Bladder

Sources:
33MalaCards
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MalaCards organs/tissues related to Neurogenic Bladder:

33
Spinal cord, Brain, Kidney, Skeletal muscle, Colon, Prostate, Endothelial, Fetal brain

Animal Models for Neurogenic Bladder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Neurogenic Bladder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.9MEOX2, CHRM2, CHRM3, GBE1, P2RX2, CASK
2MP:00036317.8CASK, OPRL1, PIP5K1C, MEOX2, CHRM2, CHRM3
3MP:00053766.9TMEM173, OPRL1, PIP5K1C, LPP, MEOX2, CHRM2

Publications for Neurogenic Bladder

Sources:
51PubMed
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Articles related to Neurogenic Bladder:

(show top 50)    (show all 519)
idTitleAuthorsYear
1
Persistent neurogenic bladder dysfunction due to infantile botulism. (24419642)
2014
2
Differences in urodynamic study variables in adult patients with neurogenic bladder and myelomeningocele before and after augmentation enterocystoplasty. (22965686)
2013
3
Investigation into neurogenic bladder in arthrogryposis multiplex congenita. (23491981)
2013
4
Outcomes of electrical stimulation of the neurogenic bladder: results of a two-year follow-up study. (23867413)
2013
5
Development of upper tract stones in patients with congenital neurogenic bladder. (23932553)
2013
6
The AdVance male sling as a minimally invasive treatment for intrinsic sphincter deficiency in patients with neurogenic bladder sphincter dysfunction: a pilot study. (22847896)
2012
7
Connective tissue and its growth factor CTGF distinguish the morphometric and molecular remodeling of the bladder in a model of neurogenic bladder. (22993071)
2012
8
Re: Bladder neck closure and suprapubic catheter placement as definitive management of neurogenic bladder. (22423929)
2012
9
Renal function in children with congenital neurogenic bladder. (21484032)
2011
10
Regenerative medicine strategies for treating neurogenic bladder. (22087419)
2011
11
Management goals for the spina bifida neurogenic bladder: a review from infancy to adulthood. (20955904)
2010
12
Emphysematous cystitis with diabetic neurogenic bladder. (20823650)
2010
13
Urologic care of the neurogenic bladder in children. (20569799)
2010
14
Neurogenic bladder in a patient with systemic lupus erythematosus and cerebral involvement. (19125134)
2009
15
The clinical and urodynamic results of a 3-month percutaneous posterior tibial nerve stimulation treatment in patients with multiple sclerosis-related neurogenic bladder dysfunction. (19373898)
2009
16
Suprapubic mass in patient with neurogenic bladder due to spinal cord injury managed with indwelling suprapubic tube. (19167046)
2009
17
Severe bladder trabeculation obviates the need for bladder outlet procedures during augmentation cystoplasty in incontinent patients with neurogenic bladder. (17970790)
2008
18
Nonsurgical management of the neurogenic bladder in children. (19030763)
2008
19
Botulinum-A toxin injections into the detrusor muscle decrease nerve growth factor bladder tissue levels in patients with neurogenic detrusor overactivity. (16697870)
2006
20
Is it possible to use urodynamic variables to predict upper urinary tract dilatation in children with neurogenic bladder-sphincter dysfunction? (17034510)
2006
21
Sexual activity in Korean male patients on clean intermittent catheterization with neurogenic bladder due to spinal cord injury. (16448431)
2006
22
Evaluation of 3 methods of bladder irrigation to treat bacteriuria in persons with neurogenic bladder. (16859225)
2006
23
Bladder epithelium is abnormal in patients with neurogenic bladder due to myelomeningocele. (15001981)
2004
24
Epidural spinal cord stimulation for neurogenic bladder. (12908692)
2003
25
Comparison between conventional cystometry and stimulated filling cystometry by diuretics in a neurogenic bladder after spinal cord injury. (12362112)
2002
26
The management of neurogenic bladder and sexual dysfunction after spinal cord injury. (11805620)
2001
27
An unusual presenting symptom of sarcoidosis: neurogenic bladder dysfunction. (11176503)
2001
28
Towards a catheter free status in neurogenic bladder dysfunction: a review of bladder management options in spinal cord injury (SCI). (11464308)
2001
29
Familial mitochondrial intestinal pseudo-obstruction and neurogenic bladder. (10868781)
2000
30
Dosage escalation of intravesical oxybutynin in the treatment of neurogenic bladder patients. (10822396)
2000
31
A therapeutic trial of acupuncture in neurogenic bladder of spinal cord injured patients--a preliminary report. (9670383)
1998
32
Use of contact laser crystal tip firing Nd:YAG to relieve urinary outflow obstruction in male neurogenic bladder patients. (9728128)
1998
33
Intravesical oxybutynin for neurogenic bladder dysfunction: less systemic side effects due to reduced first pass metabolism. (9720583)
1998
34
High incidence of occult neurogenic bladder dysfunction in neurologically intact patients with thoracolumbar spinal injuries. (9474194)
1998
35
Neurogenic bladder may be a side effect of focus resection in an epileptic patient. (9179679)
1997
36
Augmentation duracystoplasty in neurogenic bladder dysfunction. (8536133)
1995
37
Urodynamic comparison of ileum vs. sigmoid in augmentation cystoplasty for neurogenic bladder dysfunction. (7647805)
1995
38
Neurogenic bladder. (7714967)
1995
39
Responses of the human neurogenic bladder to KCl, carbachol, ATP and CaCl2. (8131037)
1994
40
DDAVP in the urological management of the difficult neurogenic bladder in spinal cord injury: preliminary report. (7869058)
1994
41
Synchronous cystoscopy and cystometry in the management of neurogenic bladder dysfunction. (8326570)
1993
42
Neurogenic bladder dysfunction in lumbar intervertebral disc prolapse. (1737251)
1992
43
Reconstruction of the lower urinary tract for neurogenic bladder: lessons from the adolescent age group. (1638344)
1992
44
Neurogenic bladder in children: urodynamic studies and results with medical conservative treatment. (1892805)
1991
45
Bladder deformities in patients with neurogenic bladder dysfunction. (1949379)
1991
46
Antibiotic cover of transurethral maneuvers with ciprofloxacin and susceptibility behavior of pathogens in patients with neurogenic bladder. (2288051)
1990
47
Re: Suppression and treatment of urinary tract infection in patients with an intermittently catheterized neurogenic bladder. (3193542)
1988
48
Significance of asymptomatic bacteriuria in neurogenic bladder disease. (6369712)
1984
49
VOIDING PRESSURE AND URINARY FLOW IN PROSTATIC HYPERTROPHY AND IN NEUROGENIC BLADDER DISORDERS. (14227133)
1964
50
Bladder dysfunction due to congenital defects (bladder neck obstruction and neurogenic bladder) in children. (14824797)
1951

Genetic Variations for Neurogenic Bladder

Expression for genes affiliated with Neurogenic Bladder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurogenic Bladder

Search GEO for disease gene expression data for Neurogenic Bladder.

Pathways for genes affiliated with Neurogenic Bladder

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Neurogenic Bladder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CHRM3, CHRM2
2
Hide members
8.8PNOC, P2RX2, TAC3, CHRM3, CHRM2, OPRL1

Compounds for genes affiliated with Neurogenic Bladder

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 50PharmGKB
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Compounds related to Neurogenic Bladder according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1n methylscopolamine4510.4CHRM2, CHRM3
25,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one4510.4CHRM2, CHRM3
3hexahydrosiladifenidol4510.4CHRM2, CHRM3
4pfhhsid4510.4CHRM2, CHRM3
5Oxyphencyclimine1110.3CHRM2, CHRM3
6Anisotropine Methylbromide1110.3CHRM3, CHRM2
7Methylscopolamine1110.3CHRM3, CHRM2
8Tridihexethyl1110.3CHRM3, CHRM2
9thiochrome2910.3CHRM2, CHRM3
10furmethide2910.3CHRM2, CHRM3
11hexocyclium2910.3CHRM3, CHRM2
12methylfurmethide2910.3CHRM2, CHRM3
13win 62,5772910.3CHRM2, CHRM3
14gö 78742910.3CHRM2, CHRM3
15tropicamide45 60 1112.3CHRM3, CHRM2
16propantheline29 1111.3CHRM3, CHRM2
17Hyoscyamine1110.3CHRM2, CHRM3
18silahexocyclium2910.3CHRM3, CHRM2
19Procyclidine1110.3CHRM2, CHRM3
20vincamine2910.3CHRM3, CHRM2
21pipecuronium45 1111.3CHRM2, CHRM3
22oxotremorine-m2910.2CHRM2, CHRM3
23eburnamonine2910.2CHRM2, CHRM3
24alcuronium2910.2CHRM3, CHRM2
25lithocholylcholine2910.2CHRM2, CHRM3
26hexahydrodifenidol2910.2CHRM2, CHRM3
27pentylthio-tztp2910.2CHRM3, CHRM2
28ufp-10160 2911.2PNOC, OPRL1
29ban orl 246010.2OPRL1, PNOC
30nociceptin6010.2OPRL1, PNOC
31win 51,7082910.2CHRM2, CHRM3
32jtc 8016010.2PNOC, OPRL1
33(+-)-j 1133976010.2OPRL1, PNOC
34arecaidine propargyl ester2910.2CHRM3, CHRM2
35Metixene1110.1CHRM2, CHRM3
36Trihexyphenidyl1110.1CHRM3, CHRM2
37hhsid2910.1CHRM2, CHRM3
38mivacurium45 1111.1CHRM3, CHRM2
39nnc 11-15852910.0CHRM2, CHRM3
40nnc 11-16072910.0CHRM2, CHRM3
41(+)aceclidine299.9CHRM2, CHRM3
42Cryptenamine119.9CHRM3, CHRM2
43brucine n-oxide299.8CHRM3, CHRM2
44atropine45 29 1111.6CHRM2, CHRM3, TAC3, PNOC
45Homatropine Methylbromide119.6CHRM3, CHRM2
46succinylcholine45 29 1111.6CHRM3, CHRM2, IGHE
47capsaicin45 2910.2IGHE, CMA1, PNOC, TAC3
48norepinephrine45 11 2410.8PNOC, IGHE, CHRM3, CHRM2, OPRL1
49histamine45 29 2410.6PNOC, CHRM2, IGHE, IGES, CMA1
50acetylcholine45 50 29 11 2412.3TAC3, CHRM2, CHRM3, IGHE, IGES, PNOC

GO Terms for genes affiliated with Neurogenic Bladder

Sources:
16Gene Ontology
See all sources

Cellular components related to Neurogenic Bladder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1focal adhesionGO:0059259.4PRUNE, LPP, PIP5K1C

Biological processes related to Neurogenic Bladder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perceptionGO:0076009.7PNOC, OPRL1

Molecular functions related to Neurogenic Bladder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled acetylcholine receptor activityGO:0169079.6CHRM3, CHRM2
2protein bindingGO:0055156.7CASK, OPRL1, LPP, MEOX2, PRUNE, CHRM3

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Sources for Neurogenic Bladder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet