MCID: NRG002
MIFTS: 56

Neurogenic Bladder malady

Neuronal diseases, Nephrological diseases categories

Summaries for Neurogenic Bladder

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63Wikipedia, 32MalaCards
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Wikipedia:63 Neurogenic bladder dysfunction, sometimes simply referred to as neurogenic bladder, is a dysfunction of... more...

MalaCards: Neurogenic Bladder, also known as neurogenic dysfunction of the urinary bladder, is related to vesicoureteral reflux and low compliance bladder. An important gene associated with Neurogenic Bladder is P2RX2 (purinergic receptor P2X, ligand-gated ion channel, 2), and among its related pathways are Muscarinic acetylcholine receptors and Class A/1 (Rhodopsin-like receptors). The drugs hyoscyamine sulfate and baclofen and the compounds pfhhsid and hexahydrosiladifenidol have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, prostate and testes, and related mouse phenotypes are respiratory system and nervous system.

Aliases & Classifications for Neurogenic Bladder

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Nephrological diseases


Aliases & Descriptions:

neurogenic bladder 8 10
neurogenic dysfunction of the urinary bladder 8
neurogenic urinary bladder disorder 8
neurogenic urinary bladder 60
neurogenic bladder nos 8
neuropathic bladder 8
bladder neurogenic 44


External Ids:

Disease Ontology8 DOID:12143
NCIt39 C79696
ICD9CM27 596.54
MeSH34 D001750

Related Diseases for Neurogenic Bladder

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Neurogenic Bladder:



Diseases related to neurogenic bladder

Clinical Features for Neurogenic Bladder

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Drugs & Therapeutics for Neurogenic Bladder

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Neurogenic Bladder

Search CenterWatch for Neurogenic Bladder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Neurogenic Bladder

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Anatomical Context for Neurogenic Bladder

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32MalaCards
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MalaCards organs/tissues related to Neurogenic Bladder:

32
Spinal cord, Prostate, Testes, Colon, Brain, Kidney, Endothelial

Animal Models for Neurogenic Bladder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neurogenic Bladder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.9MEOX2, CHRM2, CHRM3, GBE1, P2RX2, CASK
2MP:00036317.8CASK, OPRL1, PIP5K1C, MEOX2, CHRM2, CHRM3
3MP:00053766.9TMEM173, OPRL1, PIP5K1C, LPP, MEOX2, CHRM2

Publications for Neurogenic Bladder

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50PubMed
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Articles related to Neurogenic Bladder:

(show top 50)    (show all 519)
idTitleAuthorsYear
1
Persistent neurogenic bladder dysfunction due to infantile botulism. (24419642)
2014
2
Differences in urodynamic study variables in adult patients with neurogenic bladder and myelomeningocele before and after augmentation enterocystoplasty. (22965686)
2013
3
Investigation into neurogenic bladder in arthrogryposis multiplex congenita. (23491981)
2013
4
Outcomes of electrical stimulation of the neurogenic bladder: results of a two-year follow-up study. (23867413)
2013
5
Development of upper tract stones in patients with congenital neurogenic bladder. (23932553)
2013
6
The AdVance male sling as a minimally invasive treatment for intrinsic sphincter deficiency in patients with neurogenic bladder sphincter dysfunction: a pilot study. (22847896)
2012
7
Connective tissue and its growth factor CTGF distinguish the morphometric and molecular remodeling of the bladder in a model of neurogenic bladder. (22993071)
2012
8
Re: Bladder neck closure and suprapubic catheter placement as definitive management of neurogenic bladder. (22423929)
2012
9
Renal function in children with congenital neurogenic bladder. (21484032)
2011
10
Regenerative medicine strategies for treating neurogenic bladder. (22087419)
2011
11
Management goals for the spina bifida neurogenic bladder: a review from infancy to adulthood. (20955904)
2010
12
Emphysematous cystitis with diabetic neurogenic bladder. (20823650)
2010
13
Urologic care of the neurogenic bladder in children. (20569799)
2010
14
Neurogenic bladder in a patient with systemic lupus erythematosus and cerebral involvement. (19125134)
2009
15
The clinical and urodynamic results of a 3-month percutaneous posterior tibial nerve stimulation treatment in patients with multiple sclerosis-related neurogenic bladder dysfunction. (19373898)
2009
16
Suprapubic mass in patient with neurogenic bladder due to spinal cord injury managed with indwelling suprapubic tube. (19167046)
2009
17
Severe bladder trabeculation obviates the need for bladder outlet procedures during augmentation cystoplasty in incontinent patients with neurogenic bladder. (17970790)
2008
18
Nonsurgical management of the neurogenic bladder in children. (19030763)
2008
19
Botulinum-A toxin injections into the detrusor muscle decrease nerve growth factor bladder tissue levels in patients with neurogenic detrusor overactivity. (16697870)
2006
20
Is it possible to use urodynamic variables to predict upper urinary tract dilatation in children with neurogenic bladder-sphincter dysfunction? (17034510)
2006
21
Sexual activity in Korean male patients on clean intermittent catheterization with neurogenic bladder due to spinal cord injury. (16448431)
2006
22
Evaluation of 3 methods of bladder irrigation to treat bacteriuria in persons with neurogenic bladder. (16859225)
2006
23
Bladder epithelium is abnormal in patients with neurogenic bladder due to myelomeningocele. (15001981)
2004
24
Epidural spinal cord stimulation for neurogenic bladder. (12908692)
2003
25
Comparison between conventional cystometry and stimulated filling cystometry by diuretics in a neurogenic bladder after spinal cord injury. (12362112)
2002
26
The management of neurogenic bladder and sexual dysfunction after spinal cord injury. (11805620)
2001
27
An unusual presenting symptom of sarcoidosis: neurogenic bladder dysfunction. (11176503)
2001
28
Towards a catheter free status in neurogenic bladder dysfunction: a review of bladder management options in spinal cord injury (SCI). (11464308)
2001
29
Familial mitochondrial intestinal pseudo-obstruction and neurogenic bladder. (10868781)
2000
30
Dosage escalation of intravesical oxybutynin in the treatment of neurogenic bladder patients. (10822396)
2000
31
A therapeutic trial of acupuncture in neurogenic bladder of spinal cord injured patients--a preliminary report. (9670383)
1998
32
Use of contact laser crystal tip firing Nd:YAG to relieve urinary outflow obstruction in male neurogenic bladder patients. (9728128)
1998
33
Intravesical oxybutynin for neurogenic bladder dysfunction: less systemic side effects due to reduced first pass metabolism. (9720583)
1998
34
High incidence of occult neurogenic bladder dysfunction in neurologically intact patients with thoracolumbar spinal injuries. (9474194)
1998
35
Neurogenic bladder may be a side effect of focus resection in an epileptic patient. (9179679)
1997
36
Augmentation duracystoplasty in neurogenic bladder dysfunction. (8536133)
1995
37
Urodynamic comparison of ileum vs. sigmoid in augmentation cystoplasty for neurogenic bladder dysfunction. (7647805)
1995
38
Neurogenic bladder. (7714967)
1995
39
Responses of the human neurogenic bladder to KCl, carbachol, ATP and CaCl2. (8131037)
1994
40
DDAVP in the urological management of the difficult neurogenic bladder in spinal cord injury: preliminary report. (7869058)
1994
41
Synchronous cystoscopy and cystometry in the management of neurogenic bladder dysfunction. (8326570)
1993
42
Neurogenic bladder dysfunction in lumbar intervertebral disc prolapse. (1737251)
1992
43
Reconstruction of the lower urinary tract for neurogenic bladder: lessons from the adolescent age group. (1638344)
1992
44
Neurogenic bladder in children: urodynamic studies and results with medical conservative treatment. (1892805)
1991
45
Bladder deformities in patients with neurogenic bladder dysfunction. (1949379)
1991
46
Antibiotic cover of transurethral maneuvers with ciprofloxacin and susceptibility behavior of pathogens in patients with neurogenic bladder. (2288051)
1990
47
Re: Suppression and treatment of urinary tract infection in patients with an intermittently catheterized neurogenic bladder. (3193542)
1988
48
Significance of asymptomatic bacteriuria in neurogenic bladder disease. (6369712)
1984
49
VOIDING PRESSURE AND URINARY FLOW IN PROSTATIC HYPERTROPHY AND IN NEUROGENIC BLADDER DISORDERS. (14227133)
1964
50
Bladder dysfunction due to congenital defects (bladder neck obstruction and neurogenic bladder) in children. (14824797)
1951

Genetic Variations for Neurogenic Bladder

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Expression for genes affiliated with Neurogenic Bladder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurogenic Bladder

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Pathways for genes affiliated with Neurogenic Bladder

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53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Neurogenic Bladder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CHRM3, CHRM2
2
Hide members
8.8PNOC, P2RX2, TAC3, CHRM3, CHRM2, OPRL1

Compounds for genes affiliated with Neurogenic Bladder

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44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Neurogenic Bladder according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1pfhhsid4410.4CHRM3, CHRM2
2hexahydrosiladifenidol4410.4CHRM3, CHRM2
35,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one4410.4CHRM3, CHRM2
4n methylscopolamine4410.4CHRM3, CHRM2
5Oxyphencyclimine1110.3CHRM2, CHRM3
6Tridihexethyl1110.3CHRM2, CHRM3
7Methylscopolamine1110.3CHRM2, CHRM3
8Anisotropine Methylbromide1110.3CHRM2, CHRM3
9thiochrome2810.3CHRM3, CHRM2
10methylfurmethide2810.3CHRM2, CHRM3
11win 62,5772810.3CHRM2, CHRM3
12gö 78742810.3CHRM2, CHRM3
13oxotremorine-m2810.3CHRM2, CHRM3
14furmethide2810.3CHRM3, CHRM2
15Hyoscyamine1110.3CHRM2, CHRM3
16Procyclidine1110.3CHRM2, CHRM3
17pipecuronium44 1111.3CHRM2, CHRM3
18tropicamide44 59 1112.3CHRM2, CHRM3
19eburnamonine2810.3CHRM2, CHRM3
20propantheline28 1111.3CHRM3, CHRM2
21hexahydrodifenidol2810.3CHRM3, CHRM2
22pentylthio-tztp2810.2CHRM2, CHRM3
23hexocyclium2810.2CHRM2, CHRM3
24silahexocyclium2810.2CHRM2, CHRM3
25lithocholylcholine2810.2CHRM3, CHRM2
26win 51,7082810.2CHRM2, CHRM3
27vincamine2810.2CHRM2, CHRM3
28arecaidine propargyl ester2810.2CHRM2, CHRM3
29ufp-10159 2811.2OPRL1, PNOC
30(+-)-j 1133975910.2PNOC, OPRL1
31jtc 8015910.2PNOC, OPRL1
32nociceptin5910.2PNOC, OPRL1
33ban orl 245910.2PNOC, OPRL1
34alcuronium2810.2CHRM2, CHRM3
35brucine n-oxide2810.1CHRM2, CHRM3
36Homatropine Methylbromide1110.1CHRM3, CHRM2
37Cryptenamine1110.1CHRM3, CHRM2
38Trihexyphenidyl1110.1CHRM3, CHRM2
39Metixene1110.0CHRM3, CHRM2
40(+)aceclidine2810.0CHRM2, CHRM3
41mivacurium44 1110.9CHRM3, CHRM2
42hhsid289.9CHRM3, CHRM2
43nnc 11-1585289.8CHRM3, CHRM2
44atropine44 28 1111.6CHRM2, CHRM3, TAC3, PNOC
45nnc 11-1607289.6CHRM3, CHRM2
46succinylcholine44 28 1111.6IGHE, CHRM3, CHRM2
47capsaicin44 2810.2IGHE, TAC3, CMA1, PNOC
48norepinephrine44 11 2410.8OPRL1, CHRM2, CHRM3, IGHE, PNOC
49histamine44 28 2410.6CHRM2, IGHE, IGES, CMA1, PNOC
50acetylcholine44 49 28 11 2412.3PNOC, TAC3, IGES, IGHE, CHRM3, CHRM2

GO Terms for genes affiliated with Neurogenic Bladder

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16Gene Ontology
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Cellular components related to Neurogenic Bladder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1focal adhesionGO:0059259.4PRUNE, LPP, PIP5K1C

Biological processes related to Neurogenic Bladder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perceptionGO:0076009.7PNOC, OPRL1

Molecular functions related to Neurogenic Bladder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled acetylcholine receptor activityGO:0169079.6CHRM3, CHRM2
2protein bindingGO:0055156.7CASK, OPRL1, LPP, MEOX2, PRUNE, CHRM3

Products for genes affiliated with Neurogenic Bladder

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Sources for Neurogenic Bladder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet