MCID: NRG001
MIFTS: 28

Neurogenic Bowel malady

Categories: Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Neurogenic Bowel

Aliases & Descriptions for Neurogenic Bowel:

Name: Neurogenic Bowel 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13419
ICD9CM 35 564.81
MeSH 42 D055496
SNOMED-CT 64 425671009
ICD10 33 K59.2
UMLS 69 C0695242

Summaries for Neurogenic Bowel

MalaCards based summary : Neurogenic Bowel is related to spinal cord injury and pyloric stenosis. An important gene associated with Neurogenic Bowel is LMNB1 (Lamin B1). The drugs Glycerol and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and colon.

Related Diseases for Neurogenic Bowel

Graphical network of the top 20 diseases related to Neurogenic Bowel:



Diseases related to Neurogenic Bowel

Symptoms & Phenotypes for Neurogenic Bowel

Drugs & Therapeutics for Neurogenic Bowel

Drugs for Neurogenic Bowel (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Experimental Phase 4 56-81-5 753
2 Pharmaceutical Solutions Phase 4
3 Protective Agents Phase 4
4 Cola Nutraceutical Phase 4
5
Fesoterodine Approved Phase 2 286930-02-7, 286930-03-8 6918558
6 Cholinergic Agents Phase 2,Phase 1,Early Phase 1
7 Cholinergic Antagonists Phase 2,Phase 1,Early Phase 1
8 Muscarinic Antagonists Phase 2,Phase 1,Early Phase 1
9 Neurotransmitter Agents Phase 2,Phase 1,Early Phase 1
10
Neostigmine Approved, Vet_approved Phase 1,Early Phase 1 59-99-4 4456
11 Adjuvants, Anesthesia Phase 1,Early Phase 1
12 Anesthetics Phase 1,Early Phase 1
13 Autonomic Agents Phase 1,Early Phase 1
14 Cholinesterase Inhibitors Phase 1,Early Phase 1
15
Glycopyrrolate Phase 1,Early Phase 1 596-51-0 3494
16 Peripheral Nervous System Agents Phase 1,Early Phase 1
17
Epinephrine Approved, Vet_approved 51-43-4 5816
18
Norepinephrine Approved 51-41-2 439260
19 Epinephryl borate
20 Racepinephrine
21 Cathartics
22 Laxatives

Interventional clinical trials:

(show all 19)
id Name Status NCT ID Phase
1 Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury Completed NCT00286520 Phase 4
2 A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children Recruiting NCT02435069 Phase 4
3 Targin® for Chronic Pain Management in Patients With Spinal Cord Injury Not yet recruiting NCT03179475 Phase 3
4 Fesoterodine for Amelioration of Autonomic Dysreflexia (AD) Following Spinal Cord Injury (SCI) Recruiting NCT02676154 Phase 2
5 Use of Prokinetics During Inpatient Bowel Care for SCI Patients Recruiting NCT02370433 Phase 1
6 Electrical Stimulation for Continence After Spinal Cord Injury Recruiting NCT02978638 Phase 1
7 Abdominal Massage for Bowel Dysfunction Completed NCT03166007
8 Evaluation of a Novel Electronic Transanal Irrigation System - Navina™ Smart Completed NCT02709395
9 Transdermal Administration of a Prokinetic Agent for Bowel Evacuation in Persons With SCI Completed NCT02370862 Early Phase 1
10 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328
11 Evaluation of a Bowel and Bladder Health Management Program for Individuals With Spinal Cord Injury (SCI) Completed NCT01920243
12 Autonomic Dysreflexia in Spinal Cord Injury Completed NCT01059370
13 An Open, Qualitative, Prospective, Multicenter Trial of a Novel Transanal Irrigation System in Spinal Cord Injured Patients. Recruiting NCT02979808
14 Retrograde Colonic Irrigation to Manage Spina Bifida Functional Digestive Sequelae: a Multicenter, Prospective, Randomized Controlled Trial Recruiting NCT02361450
15 Contribution of Percutaneous Endoscopic Caecostomie in the Management of Severe Constipation Refractory to Medical Treatment Recruiting NCT02566746
16 Utility of an Animated Bowel Biofeedback Training Routine to Improve Bowel Function in Individuals With SCI Active, not recruiting NCT02406859
17 Spinal Cord Injury Epidural Stimulation Active, not recruiting NCT02592668
18 Afferent Stimulation to Evoke Recto-colonic Reflex for Colonic Motility Not yet recruiting NCT02641483
19 Treatment of Neurogenic Detrusor Overactivity: Early Versus Late Pudendal Nerve Stimulation in Spinal Cord Injury (SCI) Patients Suspended NCT01043848

Search NIH Clinical Center for Neurogenic Bowel

Cochrane evidence based reviews: neurogenic bowel

Genetic Tests for Neurogenic Bowel

Anatomical Context for Neurogenic Bowel

MalaCards organs/tissues related to Neurogenic Bowel:

39
Spinal Cord, Colon

Publications for Neurogenic Bowel

Articles related to Neurogenic Bowel:

(show top 50) (show all 81)
id Title Authors Year
1
What is the best way to manage neurogenic bowel dysfunction? ( 27815246 )
2016
2
Electroacupuncture at Zusanli (ST36) ameliorates colonic neuronal nitric oxide synthase upregulation in rats with neurogenic bowel dysfunction following spinal cord injury. ( 27377302 )
2016
3
Long-Term Outcomes and Longitudinal Changes of Neurogenic Bowel Management in Adults With Pediatric-Onset Spinal Cord Injury. ( 27473299 )
2016
4
Prospective evaluation of PeristeenAr transanal irrigation system with the validated neurogenic bowel dysfunction score sheet in the pediatric population. ( 26879474 )
2016
5
Medical and surgical management of neurogenic bowel. ( 27152922 )
2016
6
Assessment of severity of neurogenic bowel dysfunction in chronic patients with a simple 1-item questionnaire (PGI-S). ( 27676768 )
2016
7
Effects and Safety of Aqueous Extract of Poncirus fructus in Spinal Cord Injury with Neurogenic Bowel. ( 27738444 )
2016
8
Anorectal biofeedback for neurogenic bowel dysfunction in incomplete spinal cord injury. ( 27184916 )
2016
9
Risk Factors Associated with Neurogenic Bowel Complications and Dysfunction in Spinal Cord Injury. ( 27109330 )
2016
10
Neurogenic bowel dysfunction (NBD) translation and linguistic validation to classical Arabic. ( 27449575 )
2016
11
Neurogenic bowel dysfunction translation and linguistic validation to classical Arabic. ( 27676967 )
2016
12
Evidence base for managing neurogenic bowel dysfunction. ( 27491188 )
2016
13
Managing neurogenic bowel dysfunction: what do patients prefer? A discrete choice experiment of patient preferences for transanal irrigation and standard bowel management. ( 26937179 )
2016
14
Long-Term Cost-Effectiveness of Transanal Irrigation in Patients with Neurogenic Bowel Dysfunction. ( 27557052 )
2016
15
Palliation of Neurogenic Bowel #317. ( 27841955 )
2016
16
Outcomes of neurogenic bowel management in individuals living with a spinal cord injury for at least 10 years. ( 25620716 )
2015
17
Outcomes of bowel program in spinal cord injury patients with neurogenic bowel dysfunction. ( 26330842 )
2015
18
Long-Term Cost-Effectiveness of Transanal Irrigation In Patients With Neurogenic Bowel Dysfunction Who Have Failed Standard Bowel Care. ( 26532036 )
2015
19
Comparison of efficacies of vegetable oil based and polyethylene glycol based bisacodyl suppositories in treating patients with neurogenic bowel dysfunction after spinal cord injury: a meta-analysis. ( 25417608 )
2014
20
Neurogenic Bowel after Spinal Cord Injury from the Perspective of Support Providers: A Phenomenological Study. ( 25305370 )
2014
21
Ultrasonic measurement of rectal diameter and area in neurogenic bowel with spinal cord injury. ( 25432419 )
2014
22
Development, reliability and validation of a neurogenic bowel dysfunction score in pediatric patients with spina bifida. ( 25400229 )
2014
23
Hydronephrosis: an unusual complication of neurogenic bowel in a patient with spinal cord injury: a case report. ( 24902647 )
2014
24
Independence does not come with the method - treatment of neurogenic bowel dysfunction in children with myelomeningocele. ( 25048689 )
2014
25
Development of hydronephrosis secondary to poorly managed neurogenic bowel requiring surgical disimpaction in a patient with spinal cord injury: A case report. ( 24617444 )
2014
26
A Phenomenological Study of Neurogenic Bowel from the Perspective of Individuals Living with Spinal Cord Injury. ( 25172370 )
2014
27
Neurogenic bowel management after spinal cord injury: Malaysian experience. ( 23053003 )
2013
28
Outcomes following fecal continence procedures in patients with neurogenic bowel dysfunction. ( 23270910 )
2013
29
Rectal hyposensitivity for non-noxious stimuli, postprandial hypersensitivity and its correlation with symptoms in complete spinal cord injury with neurogenic bowel dysfunction. ( 22929208 )
2013
30
Abdominal Pain: A Comparison between Neurogenic Bowel Dysfunction and Chronic Idiopathic Constipation. ( 24159329 )
2013
31
Parents of children with neurogenic bowel dysfunction: their experiences of using transanal irrigation with their child. ( 24261461 )
2013
32
Neurogenic bowel. ( 23312643 )
2013
33
Neurostimulation for neurogenic bowel dysfunction. ( 23573076 )
2013
34
Pudendal nerve stimulation: A potential tool for neurogenic bowel dysfunction! ( 23804532 )
2013
35
An evidence-based review of the use of transanal irrigation in children and young people with neurogenic bowel. ( 23229617 )
2013
36
Experience with glycerin for antegrade continence enema in patients with neurogenic bowel. ( 22986031 )
2013
37
Transanal irrigation in the management of neurogenic bowel dysfunction. ( 23008885 )
2012
38
Characteristics of neurogenic bowel in spinal cord injury and perceived quality of life. ( 22549630 )
2012
39
Morphological abnormalities of the recto-anal inhibitory reflex reflects symptom pattern in neurogenic bowel. ( 22427172 )
2012
40
Transcutaneous interferential electrical stimulation for management of neurogenic bowel dysfunction in children with myelomeningocele. ( 22065105 )
2012
41
Management of neurogenic bowel dysfunction. ( 22222963 )
2011
42
Neurogenic bowel dysfunction in patients with spinal cord injury, myelomeningocele, multiple sclerosis and Parkinson's disease. ( 22171138 )
2011
43
Prediction of severe neurogenic bowel dysfunction in persons with spinal cord injury. ( 20065986 )
2010
44
Managing neurogenic bowel dysfunction. ( 20511302 )
2010
45
Achieving continence with a neurogenic bowel. ( 20883889 )
2010
46
Clinical outcome of sacral neuromodulation in incomplete spinal cord-injured patients suffering from neurogenic bowel dysfunctions. ( 19668257 )
2010
47
Neurogenic bowel management after spinal cord injury. ( 20927108 )
2010
48
The need for manual evacuation and oral laxatives in the management of neurogenic bowel dysfunction after spinal cord injury: a randomized controlled trial of a stepwise protocol. ( 19949417 )
2010
49
Neurogenic bowel management after spinal cord injury: a systematic review of the evidence. ( 20212501 )
2010
50
Review of the efficacy and safety of transanal irrigation for neurogenic bowel dysfunction. ( 20142830 )
2010

Variations for Neurogenic Bowel

Expression for Neurogenic Bowel

Search GEO for disease gene expression data for Neurogenic Bowel.

Pathways for Neurogenic Bowel

GO Terms for Neurogenic Bowel

Cellular components related to Neurogenic Bowel according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CA2 EDN3 KIT LY86 LY96 PTGIS

Biological processes related to Neurogenic Bowel according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 melanocyte differentiation GO:0030318 9.16 EDN3 KIT
2 positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 8.96 LY86 LY96
3 regulation of developmental pigmentation GO:0048070 8.62 EDN3 KIT

Sources for Neurogenic Bowel

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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