MCID: NRG004
MIFTS: 27

Neurogenic Diabetes Insipidus malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Neurogenic Diabetes Insipidus

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Aliases & Descriptions for Neurogenic Diabetes Insipidus:

Name: Neurogenic Diabetes Insipidus 45
Central Diabetes Insipidus 45 65
Diabetes Insipidus Neurohypophyseal 45
Neurohypophyseal Diabetes Insipidus 45
 
Diabetes Insipidus Cranial Type 45
Diabetes Insipidus Neurogenic 45
Pituitary Diabetes Insipidus 45

Characteristics:

HPO:

61


Classifications:



Summaries for Neurogenic Diabetes Insipidus

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NIH Rare Diseases:45 Neurogenic diabetes insipidus is a disease that causes frequent urination. this type of diabetes insipidus results from damage to the pituitary gland, which disrupts the normal storage and release of antidiuretic hormone (adh). when this hormone reaches the kidneys, it directs them to make less urine. damage to the pituitary gland can be caused by different diseases as well as by head injuries, neurosurgery, or genetic disorders. to treat the adh deficiency that results from any kind of damage to the pituitary, a synthetic hormone called desmopressin can be taken by an injection, a nasal spray, or a pill. last updated: 5/18/2011

MalaCards based summary: Neurogenic Diabetes Insipidus, also known as central diabetes insipidus, is related to diabetes insipidus, neurohypophyseal and hereditary central diabetes insipidus, and has symptoms including hypokalemia, polydipsia and alkalosis. An important gene associated with Neurogenic Diabetes Insipidus is AVP (Arginine Vasopressin). Affiliated tissues include pituitary, brain and kidney.

Wikipedia:68 Neurogenic diabetes insipidus, more commonly known as central diabetes insipidus, is due to a lack of... more...

Related Diseases for Neurogenic Diabetes Insipidus

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Diseases related to Neurogenic Diabetes Insipidus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus, neurohypophyseal11.5
2hereditary central diabetes insipidus11.2
3acquired central diabetes insipidus11.2
4diabetes insipidus10.5
5diabetes insipidus, nephrogenic10.2
6systemic lupus erythematosus9.9
7lung cancer9.9
8brain injury9.9
9traumatic brain injury9.9
10cerebritis9.9
11lupus erythematosus9.9
12encephalitis9.9
13encephalopathy9.9

Graphical network of diseases related to Neurogenic Diabetes Insipidus:



Diseases related to neurogenic diabetes insipidus

Symptoms for Neurogenic Diabetes Insipidus

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HPO human phenotypes related to Neurogenic Diabetes Insipidus:

(show all 6)
id Description Frequency HPO Source Accession
1 hypokalemia HP:0002900
2 polydipsia HP:0001959
3 alkalosis HP:0001948
4 central diabetes insipidus HP:0000863
5 hydronephrosis HP:0000126
6 polyuria HP:0000103

Drugs & Therapeutics for Neurogenic Diabetes Insipidus

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Drugs for Neurogenic Diabetes Insipidus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Natriuretic AgentsPhase 31403
2VasopressinsPhase 3260
3HemostaticsPhase 31082
4Deamino Arginine VasopressinPhase 368
5Arginine VasopressinPhase 3264
6CoagulantsPhase 31042
7arginineNutraceuticalPhase 3364
8Vasoconstrictor Agents1303

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Minirin Melt in Japanese Patients With Central Diabetes Insipidus (CDI).CompletedNCT01280188Phase 3
2Vasopressin Deficiency in Hemorrhagic ShockCompletedNCT01107314
3Study of the Pathogenesis and Pathophysiology of Familial Neurohypophyseal Diabetes InsipidusCompletedNCT00004363
4Copeptin During a Standardized Psychological Stress TestCompletedNCT01866137
5Evaluation of Plasma Volume Using Ultrasound in Disorders of Fluid With SodiumActive, not recruitingNCT01547650

Search NIH Clinical Center for Neurogenic Diabetes Insipidus

Genetic Tests for Neurogenic Diabetes Insipidus

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Anatomical Context for Neurogenic Diabetes Insipidus

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MalaCards organs/tissues related to Neurogenic Diabetes Insipidus:

33
Pituitary, Brain, Kidney, Testes, Prostate, Breast, B cells

Animal Models for Neurogenic Diabetes Insipidus or affiliated genes

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Publications for Neurogenic Diabetes Insipidus

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Articles related to Neurogenic Diabetes Insipidus:

(show all 20)
idTitleAuthorsYear
1
Buccally Administered Intranasal Desmopressin Acetate for the Treatment of Neurogenic Diabetes Insipidus in Infancy. (27011115)
2016
2
A case of hypokalemic paralysis in a patient with neurogenic diabetes insipidus. (24707338)
2014
3
Late onset of familial neurogenic diabetes insipidus in monozygotic twins. (24156710)
2013
4
Central neurogenic diabetes insipidus, syndrome of inappropriate secretion of antidiuretic hormone, and cerebral salt-wasting syndrome in traumatic brain injury. (22467619)
2012
5
Treatment of neurogenic diabetes insipidus. (22071315)
2011
6
Neurogenic diabetes insipidus presenting in a patient with subacute liver failure: a case report. (20673320)
2010
7
Neurogenic diabetes insipidus. (17080264)
2006
8
Identification of a new mutation (CysII6Gly) in a family with neurogenic diabetes insipidus]. (10827849)
2000
9
Neurogenic diabetes insipidus in patients with systemic lupus erythematosus. (9709193)
1998
10
Neurogenic diabetes insipidus in children with hypoxic encephalopathy: six new cases and a review of the literature. (8929736)
1996
11
Continuous infusion of vasopressin in comatose children with neurogenic diabetes insipidus. (8821902)
1995
12
Neurogenic diabetes insipidus in a child with fatal Coxsackie virus B1 encephalitis. (8821910)
1995
13
Neurogenic diabetes insipidus: an unusual clinical presentation of small cell lung cancer. (8390898)
1993
14
Neurogenic diabetes insipidus in an initially healthy neonate. (2588585)
1989
15
Neurogenic diabetes insipidus in a sheep. (3944284)
1986
16
Idiopathic neurogenic diabetes insipidus in a cat. (6639529)
1983
17
Occurrence of diabetes mellitus in neurogenic diabetes insipidus. (7331673)
1981
18
Nephrology forum: neurogenic diabetes insipidus. (480789)
1979
19
The use of 1-desamino-8-D-arginine vasopressin (DDAVP) in the management of neurogenic diabetes insipidus (multiple etiologies in pediatric patients). (492086)
1979
20
Neurogenic diabetes insipidus: management with dDAVP (1-desamino-8-D arginine vasopressin). (626447)
1978

Variations for Neurogenic Diabetes Insipidus

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Expression for genes affiliated with Neurogenic Diabetes Insipidus

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Search GEO for disease gene expression data for Neurogenic Diabetes Insipidus.

Pathways for genes affiliated with Neurogenic Diabetes Insipidus

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GO Terms for genes affiliated with Neurogenic Diabetes Insipidus

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Sources for Neurogenic Diabetes Insipidus

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet