MCID: NRG005
MIFTS: 25

Neurogenic Hypertension malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Neurogenic Hypertension

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Aliases & Descriptions for Neurogenic Hypertension:

Name: Neurogenic Hypertension 46 66

Classifications:



Summaries for Neurogenic Hypertension

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MalaCards based summary: Neurogenic Hypertension is related to cervicitis and neuronitis, and has symptoms including cushingoid facies An important gene associated with Neurogenic Hypertension is ACE2 (Angiotensin I Converting Enzyme 2), and among its related pathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Affiliated tissues include brain, kidney and spinal cord.

Related Diseases for Neurogenic Hypertension

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Diseases related to Neurogenic Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
idRelated DiseaseScoreTop Affiliating Genes
1cervicitis9.9
2neuronitis9.9
3cerebritis9.8
4obesity9.7
5atherosclerosis9.7
6sleep apnea9.7
7obstructive sleep apnea9.7
8renal hypertension9.7
9cerebral atherosclerosis9.7
10porphyria9.7
11thyroiditis9.7
12hypoxia9.7
13syncope9.7
14neuroma biliary tract9.5ACE2, ENPEP

Graphical network of diseases related to Neurogenic Hypertension:



Diseases related to neurogenic hypertension

Symptoms for Neurogenic Hypertension

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UMLS symptoms related to Neurogenic Hypertension:


cushingoid facies

Drugs & Therapeutics for Neurogenic Hypertension

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Drugs for Neurogenic Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1carnitineNutraceuticalPhase 3152
2
MinocyclinePhase 1, Phase 221610118-90-85281021
Synonyms:
(2Z,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE
(4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10118-90-8
13614-98-7 (mono-hydrochloride)
4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
4708-96-7
7-Dimethylamino-6-demethyl-6-deoxytetracycline
AC1NQXWM
BRN 3077644
Bio-0062
Borymycin
C07225
C23H27N3O7
CHEBI:50694
CHEBI:529981
CHEMBL1434
CHEMBL259172
CID5281021
CL 59806
CRL-1605 & Minocycline
D05045
HMS2090D03
HSDB 3130
 
LMPK07000002
LS-93850
Lactoferrin B & Minocycline
Lactoferrin H & Minocycline
MINO
MIY
Minociclina
Minociclina [INN-Spanish]
Minociclinum
Minocin
Minocin (Hydrochloride)
Minocline
Minocyclin
Minocycline (USAN/INN)
Minocycline Monohydrochloride
Minocycline [USAN:BAN:INN]
Minocyclinum
Minocyclinum [INN-Latin]
NCGC00178854-01
NSC 141993
NSC141993
UNII-FYY3R43WGO
Vectrin (Hydrochloride)
minociclinum
minocycline
nchembio.559-comp1
3
FesoterodinePhase 260286930-02-7, 286930-03-86918558
Synonyms:
FESO
 
Fesoterodine
Toviaz

Interventional clinical trials:

idNameStatusNCT IDPhase
1Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in ChildrenRecruitingNCT02192580Phase 3
2L-carnitine on the Prevention of Renal Scarring in Acute PyelonephritisRecruitingNCT02007889Phase 3
3Fesoterodine for Amelioration of Autonomic Dysreflexia (AD) Following Spinal Cord Injury (SCI)RecruitingNCT02676154Phase 2
4Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive PatientsNot yet recruitingNCT02133885Phase 1, Phase 2
5Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive PatientsRecruitingNCT02133872Phase 1
6Study 3: Minocycline Decreases Microglia ActivationNot yet recruitingNCT02213575Phase 1
7Adolescent Blood Pressure Variation and Ventricular MassCompletedNCT00005200
8Brain fMRT In Takotsubo CardiomyopathyRecruitingNCT02240056

Search NIH Clinical Center for Neurogenic Hypertension

Genetic Tests for Neurogenic Hypertension

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Anatomical Context for Neurogenic Hypertension

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MalaCards organs/tissues related to Neurogenic Hypertension:

34
Brain, Kidney, Spinal cord, Medulla oblongata, Hypothalamus, Heart, Pons

Animal Models for Neurogenic Hypertension or affiliated genes

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Publications for Neurogenic Hypertension

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Articles related to Neurogenic Hypertension:

(show top 50)    (show all 135)
idTitleAuthorsYear
1
I+-Lipoic acid reduces neurogenic hypertension by blunting oxidative stress-mediated increase in ADAM17. (26254330)
2015
2
Presympathetic neuron dysfunction--time to reconsider increased intrinsic activity as the cause of neurogenic hypertension. (24987020)
2014
3
Visualizing oxidative stress-induced depression of cardiac vagal baroreflex by MRI/DTI in a mouse neurogenic hypertension model. (23747290)
2013
4
Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension. (24014829)
2013
5
Stabilization of hypoxia inducible factor-1I+ ameliorates acute renal neurogenic hypertension. (24309492)
2013
6
Redox-sensitive oxidation and phosphorylation of PTEN contribute to enhanced activation of PI3K/Akt signaling in rostral ventrolateral medulla and neurogenic hypertension in spontaneously hypertensive rats. (22746319)
2013
7
Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice. (24275840)
2013
8
Neurogenic hypertension: revelations from genome-wide gene expression profiling. (22639016)
2012
9
Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation. (22958438)
2012
10
Chiari I malformation with neurogenic hypertension: case report. (22890471)
2012
11
Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension. (21755262)
2011
12
Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. (19926873)
2010
13
Neurogenic hypertension. (20407134)
2010
14
Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension. (19762685)
2009
15
Is neurogenic hypertension related to vascular inflammation of the brainstem? (18585782)
2009
16
Signalling across the blood brain barrier by angiotensin II: novel implications for neurogenic hypertension. (18443753)
2008
17
Neurovascular compression of the medulla: can it cause neurogenic hypertension? (17215662)
2007
18
Circulating angiotensin II and dietary salt: converging signals for neurogenic hypertension. (17519130)
2007
19
Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats. (16716903)
2006
20
Losartan reduces central and peripheral sympathetic nerve activity in a rat model of neurogenic hypertension. (12052849)
2002
21
Unloading arterial baroreceptors causes neurogenic hypertension. (11893608)
2002
22
The role of MRI in screening for neurogenic hypertension. (10663483)
2000
23
Microvascular decompression of the left lateral medulla oblongata for severe refractory neurogenic hypertension. (9894990)
1999
24
Neurogenic hypertension. A new MRI protocol for the evaluation of neurovascular compression of the cranial nerves IX and X root-entry zone. (10587874)
1999
25
A limited renal injury may cause a permanent form of neurogenic hypertension. (9657632)
1998
26
Neurogenic hypertension. (8421217)
1993
27
Neurogenic hypertension: etiology and surgical treatment. I. Observations in 53 patients. (3977442)
1985
28
Sympathoadrenal dysfunction in rats with chronic neurogenic hypertension. (3979427)
1985
29
Hemodynamic and neural mechanisms of acute neurogenic hypertension in the rat. (6507647)
1984
30
Central serotonergic activity after neurogenic hypertension. (6832215)
1983
31
Norepinephrine release and vascular response elicited by nerve stimulation in rats with chronic neurogenic hypertension. (6312017)
1983
32
Presynaptic dopamine receptor stimulation and the antihypertensive action of pergolide in experimental neurogenic hypertension. (7122527)
1982
33
Naloxone and acute neurogenic hypertension in anaesthetized dogs. (7138086)
1982
34
Neurogenic hypertension revisited. (7018799)
1981
35
Neurogenic hypertension related to vascular compression of the lateral medulla. (7432603)
1980
36
Plasma prostaglandin E during neurogenic hypertension in tetraplegic man. (1204295)
1975
37
Altered norepinephrine synthesis of splanchnic vessels in neurogenic hypertension. (4152768)
1974
38
Effects of p-chlorophenylalanine on blood pressure and heart rate in normal rabbits and rabbits with neurogenic hypertension. (4282070)
1974
39
Hemodynamic characteristics of chronic experimental neurogenic hypertension in unanesthetized dogs. (5786795)
1969
40
EEG in experimental neurogenic hypertension. (Evaluation with Fourier analysis). (5839145)
1965
41
Neurogenic hypertension. (14420562)
1959
42
Experimental psycho-neurogenic hypertension and its treatment with hydrogenated ergot alkaloids (hydergine). (13339143)
1956
43
The effect of dietary sodium-potassium relations on the experimental renal and neurogenic hypertension of the rat. (13372358)
1956
44
Thyroid gland, gonads and experimental neurogenic hypertension. (13262069)
1955
45
Neurogenic hypertension in man in porphyria: transient hypertension and tachycardia caused by disruption of the carotid sinus; review of buffer nerve mechanism. (13170848)
1954
46
Cortical ablations in dogs with chronic neurogenic hypertension. (13123578)
1954
47
The role of the adrenals in experimental neurogenic hypertension. (13093058)
1953
48
Effects of repeated oral doses of quinine and quinidine on the blood pressure and renal circulation of dogs with experimental neurogenic hypertension. (18102675)
1948
49
Effect of experimental neurogenic hypertension on renal blood flow and glomerular filtration rates in intact denervated kidneys of unanesthetized rabbits with adrenal glands demedullated. (20268824)
1947
50
THE CIRCULATION IN EXPERIMENTAL NEUROGENIC HYPERTENSION. (16695240)
1945

Variations for Neurogenic Hypertension

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Expression for genes affiliated with Neurogenic Hypertension

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Search GEO for disease gene expression data for Neurogenic Hypertension.

Pathways for genes affiliated with Neurogenic Hypertension

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GO Terms for genes affiliated with Neurogenic Hypertension

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Biological processes related to Neurogenic Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1angiotensin catabolic process in bloodGO:00020059.4ACE2, ENPEP
2regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.2ACE2, ENPEP
3angiotensin maturationGO:00020039.1ACE2, ENPEP

Molecular functions related to Neurogenic Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1zinc ion bindingGO:00082709.1ACE2, ENPEP
2metallopeptidase activityGO:00082378.8ACE2, ENPEP

Sources for Neurogenic Hypertension

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet