MCID: NRG005
MIFTS: 30

Neurogenic Hypertension malady

Rare diseases, Neuronal diseases categories

Summaries for Neurogenic Hypertension

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34MalaCards
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MalaCards: Neurogenic Hypertension is related to hypertension and cervicitis. An important gene associated with Neurogenic Hypertension is INS (insulin), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Selected targets of HNF1. The compounds arginine and alanine have been mentioned in the context of this disorder. Affiliated tissues include brain, medulla oblongata and kidney.

Aliases & Classifications for Neurogenic Hypertension

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neurogenic hypertension 44 63


Related Diseases for Neurogenic Hypertension

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18GeneCards, 19GeneDecks
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Diseases related to Neurogenic Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.5INS, ACE2, ENPEP
2cervicitis10.3
3cerebritis10.2
4obstructive sleep apnea10.0
5cerebral atherosclerosis10.0
6atherosclerosis10.0
7porphyria10.0
8renal hypertension10.0
9sleep apnea10.0
10thyroiditis10.0
11hypoxia10.0
12essential hypertension10.0ACE2, INS
13diabetic nephropathy10.0INS, ACE2
14primary hyperoxaluria10.0INS, ACE2
15proteinuria10.0INS, ACE2
16galactosemia10.0INS, ACE2

Graphical network of diseases related to Neurogenic Hypertension:



Diseases related to neurogenic hypertension

Symptoms for Neurogenic Hypertension

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Drugs & Therapeutics for Neurogenic Hypertension

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Neurogenic Hypertension

Drug clinical trials:

Search ClinicalTrials for Neurogenic Hypertension

Search NIH Clinical Center for Neurogenic Hypertension

Search CenterWatch for Neurogenic Hypertension

Genetic Tests for Neurogenic Hypertension

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Anatomical Context for Neurogenic Hypertension

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34MalaCards
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MalaCards organs/tissues related to Neurogenic Hypertension:

34
Brain, Medulla oblongata, Kidney, Hypothalamus, Spinal cord, Heart, Thyroid, Adrenal gland, Pons

Animal Models for Neurogenic Hypertension or affiliated genes

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Publications for Neurogenic Hypertension

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53PubMed
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Articles related to Neurogenic Hypertension:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
Visualizing oxidative stress-induced depression of cardiac vagal baroreflex by MRI/DTI in a mouse neurogenic hypertension model. (23747290)
2013
2
Stabilization of hypoxia inducible factor-1I+ ameliorates acute renal neurogenic hypertension. (24309492)
2013
3
Neurogenic hypertension: revelations from genome-wide gene expression profiling. (22639016)
2012
4
Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation. (22958438)
2012
5
Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link? (22562144)
2012
6
Contributions of vascular inflammation in the brainstem for neurogenic hypertension. (21601658)
2011
7
Coupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension. (21445721)
2011
8
Global identification of the genes and pathways differentially expressed in hypothalamus in early and established neurogenic hypertension. (21487032)
2011
9
Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. (19926873)
2010
10
Inflammation and neurogenic hypertension: a new role for the circumventricular organs? (20651292)
2010
11
Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension. (19762685)
2009
12
Do changes in the coupling between respiratory and sympathetic activities contribute to neurogenic hypertension? (19413588)
2009
13
Is neurogenic hypertension related to vascular inflammation of the brainstem? (18585782)
2009
14
Signalling across the blood brain barrier by angiotensin II: novel implications for neurogenic hypertension. (18443753)
2008
15
Aminopeptidase A: could it be a novel target for neurogenic hypertension? (18362227)
2008
16
Effect of renal injury-induced neurogenic hypertension on NO synthase, caveolin-1, AKt, calmodulin and soluble guanylate cyclase expressions in the kidney. (17122386)
2007
17
Neurovascular compression of the medulla: can it cause neurogenic hypertension? (17215662)
2007
18
Losartan reduces central and peripheral sympathetic nerve activity in a rat model of neurogenic hypertension. (12052849)
2002
19
Unloading arterial baroreceptors causes neurogenic hypertension. (11893608)
2002
20
Microvascular decompression of the left lateral medulla oblongata for severe refractory neurogenic hypertension. (10069614)
1999
21
Microvascular decompression of the left lateral medulla oblongata for severe refractory neurogenic hypertension. (10515496)
1999
22
Microvascular decompression of the left lateral medulla oblongata for severe refractory neurogenic hypertension. (9894990)
1999
23
The defense reaction: a common denominator of coronary risk and blood pressure in neurogenic hypertension? (7735282)
1995
24
Neurogenic hypertension. (8421217)
1993
25
Urinary kallikrein excretion in neurogenic hypertension in the dogs: possible relationship between kallikrein excretion and catecholamines. (2692416)
1989
26
Attenuation of neurogenic hypertension by chronic converting enzyme inhibition. (2698949)
1989
27
Forebrain mechanisms in neurogenic hypertension. (3690390)
1987
28
Relationship between arterial blood pressure and plasma norepinephrine levels in a patient with neurogenic hypertension. (3799645)
1986
29
Circulating and tissue catecholamines in rats with chronic neurogenic hypertension. (3718427)
1986
30
Neurogenic hypertension: etiology and surgical treatment. II. Observations in an experimental nonhuman primate model. (4015232)
1985
31
Hemodynamic and neural mechanisms of acute neurogenic hypertension in the rat. (6507647)
1984
32
Central serotonergic activity after neurogenic hypertension. (6832215)
1983
33
Norepinephrine release and vascular response elicited by nerve stimulation in rats with chronic neurogenic hypertension. (6312017)
1983
34
Neurogenic hypertension after depletion of norepinephrine in anterior hypothalamus induced by 6-hydroxydopamine administration into the ventral pons: role of serotonin. (6405300)
1983
35
Presynaptic dopamine receptor stimulation and the antihypertensive action of pergolide in experimental neurogenic hypertension. (7122527)
1982
36
The nucleus tractus solitarius and experimental neurogenic hypertension: evidence for a central neural imbalance hypothesis of hypertensive disease. (7010944)
1981
37
Aortic histomine syntesis in experimental neurogenic hypertension. (1129333)
1975
38
The central nervous system and neurogenic hypertension. (4600581)
1974
39
Altered norepinephrine synthesis of splanchnic vessels in neurogenic hypertension. (4152768)
1974
40
Effects of p-chlorophenylalanine on blood pressure and heart rate in normal rabbits and rabbits with neurogenic hypertension. (4282070)
1974
41
What is hypertension? Recent studies on neurogenic hypertension. (4929434)
1971
42
Neurogenic hypertension, with special reference to the central neurogenic effects of angiotensin. (4319093)
1970
43
Hemodynamic characteristics of chronic experimental neurogenic hypertension in unanesthetized dogs. (5786795)
1969
44
Aorta wall electrolytes in hypertensive rats. The effect of saline and neurogenic hypertension. (13949962)
1962
45
Arterial hypertension in dogs. II. The effects of neurogenic hypertension with a study of periodic renal biopsies over a seven-year period. (13279130)
1956
46
Experimental psycho-neurogenic hypertension and its treatment with hydrogenated ergot alkaloids (hydergine). (13339143)
1956
47
Role of the adrenals and the hypophysis in experimental neurogenic hypertension. (13305581)
1955
48
Neurogenic hypertension in man in porphyria: transient hypertension and tachycardia caused by disruption of the carotid sinus; review of buffer nerve mechanism. (13170848)
1954
49
The role of the adrenals in experimental neurogenic hypertension. (13093058)
1953
50
Blood Pressure of Renal and of Early and Late Neurogenic Hypertension Dogs after Low Cervical Cord Section. (17858716)
1945

Variations for Neurogenic Hypertension

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Expression for genes affiliated with Neurogenic Hypertension

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurogenic Hypertension

Search GEO for disease gene expression data for Neurogenic Hypertension.

Pathways for genes affiliated with Neurogenic Hypertension

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51PathCards, 52PharmGKB, 31KEGG, 39NCBI BioSystems Database, 13EMD Millipore, 56Reactome
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Pathways related to Neurogenic Hypertension according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1ENPEP, ACE2
29.0INS, ACE2
3
Show member pathways
8.5ENPEP, ACE2, INS
4
Show member pathways
8.5ENPEP, ACE2, INS

Compounds for genes affiliated with Neurogenic Hypertension

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46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB
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Compounds related to Neurogenic Hypertension according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1arginine469.3INS, ENPEP
2alanine469.3ENPEP, INS
3leucine469.2ENPEP, ACE2
4ramipril46 1210.2ACE2, INS
5cholesterol46 30 25 1212.1ACE2, INS
6glutamate469.0ENPEP, INS
7zinc46 2510.0ENPEP, ACE2

GO Terms for genes affiliated with Neurogenic Hypertension

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17Gene Ontology
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Biological processes related to Neurogenic Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:0072679.3ENPEP, INS
2angiotensin catabolic process in bloodGO:0020059.2ENPEP, ACE2
3regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.1ENPEP, ACE2
4angiotensin maturationGO:0020039.0ACE2, ENPEP
5cellular protein metabolic processGO:0442678.2ENPEP, ACE2, INS

Products for genes affiliated with Neurogenic Hypertension

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Sources for Neurogenic Hypertension

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet