MCID: NRG005
MIFTS: 31

Neurogenic Hypertension malady

Rare diseases, Neuronal diseases categories
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Summaries for Neurogenic Hypertension

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MalaCards based summary: Neurogenic Hypertension is related to hypertension and cervicitis. An important gene associated with Neurogenic Hypertension is INS (insulin), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Selected targets of HNF1. The compounds arginine and alanine have been mentioned in the context of this disorder. Affiliated tissues include brain, medulla oblongata and kidney.

Aliases & Classifications for Neurogenic Hypertension

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Neurogenic Hypertension, Aliases & Descriptions:

Name: Neurogenic Hypertension 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Related Diseases for Neurogenic Hypertension

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Diseases related to Neurogenic Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.1INS, ACE2, ENPEP
2cervicitis10.3
3neuronitis10.2
4cerebritis10.2
5atherosclerosis10.0
6obstructive sleep apnea10.0
7cerebral atherosclerosis10.0
8porphyria10.0
9renal hypertension10.0
10sleep apnea10.0
11thyroiditis10.0
12hypoxia10.0
13essential hypertension10.0ACE2, INS
14diabetic nephropathy10.0INS, ACE2
15primary hyperoxaluria10.0INS, ACE2
16proteinuria9.9INS, ACE2
17galactosemia9.8INS, ACE2

Graphical network of diseases related to Neurogenic Hypertension:



Diseases related to neurogenic hypertension

Symptoms for Neurogenic Hypertension

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Drugs & Therapeutics for Neurogenic Hypertension

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Drug clinical trials:

Search ClinicalTrials for Neurogenic Hypertension

Search NIH Clinical Center for Neurogenic Hypertension

Genetic Tests for Neurogenic Hypertension

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Anatomical Context for Neurogenic Hypertension

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MalaCards organs/tissues related to Neurogenic Hypertension:

32
Brain, Medulla oblongata, Kidney, Hypothalamus, Spinal cord, Heart, Thyroid, Adrenal gland, Pons

Animal Models for Neurogenic Hypertension or affiliated genes

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Publications for Neurogenic Hypertension

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Articles related to Neurogenic Hypertension:

(show top 50)    (show all 127)
idTitleAuthorsYear
1
Visualizing oxidative stress-induced depression of cardiac vagal baroreflex by MRI/DTI in a mouse neurogenic hypertension model. (23747290)
2013
2
Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension. (24014829)
2013
3
Stabilization of hypoxia inducible factor-1I+ ameliorates acute renal neurogenic hypertension. (24309492)
2013
4
Neurogenic hypertension: revelations from genome-wide gene expression profiling. (22639016)
2012
5
Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation. (22958438)
2012
6
Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link? (22562144)
2012
7
Coupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension. (21445721)
2011
8
Global identification of the genes and pathways differentially expressed in hypothalamus in early and established neurogenic hypertension. (21487032)
2011
9
Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. (19926873)
2010
10
Inflammation and neurogenic hypertension: a new role for the circumventricular organs? (20651292)
2010
11
Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension. (19762685)
2009
12
Do changes in the coupling between respiratory and sympathetic activities contribute to neurogenic hypertension? (19413588)
2009
13
Is neurogenic hypertension related to vascular inflammation of the brainstem? (18585782)
2009
14
Signalling across the blood brain barrier by angiotensin II: novel implications for neurogenic hypertension. (18443753)
2008
15
Aminopeptidase A: could it be a novel target for neurogenic hypertension? (18362227)
2008
16
Effect of renal injury-induced neurogenic hypertension on NO synthase, caveolin-1, AKt, calmodulin and soluble guanylate cyclase expressions in the kidney. (17122386)
2007
17
Neurovascular compression of the medulla: can it cause neurogenic hypertension? (17215662)
2007
18
Losartan reduces central and peripheral sympathetic nerve activity in a rat model of neurogenic hypertension. (12052849)
2002
19
Unloading arterial baroreceptors causes neurogenic hypertension. (11893608)
2002
20
Microvascular decompression of the left lateral medulla oblongata for severe refractory neurogenic hypertension. (10069614)
1999
21
Microvascular decompression of the left lateral medulla oblongata for severe refractory neurogenic hypertension. (10515496)
1999
22
Microvascular decompression of the left lateral medulla oblongata for severe refractory neurogenic hypertension. (9894990)
1999
23
The defense reaction: a common denominator of coronary risk and blood pressure in neurogenic hypertension? (7735282)
1995
24
Neurogenic hypertension. (8421217)
1993
25
Urinary kallikrein excretion in neurogenic hypertension in the dogs: possible relationship between kallikrein excretion and catecholamines. (2692416)
1989
26
Forebrain mechanisms in neurogenic hypertension. (3690390)
1987
27
Relationship between arterial blood pressure and plasma norepinephrine levels in a patient with neurogenic hypertension. (3799645)
1986
28
Circulating and tissue catecholamines in rats with chronic neurogenic hypertension. (3718427)
1986
29
Neurogenic hypertension: etiology and surgical treatment. II. Observations in an experimental nonhuman primate model. (4015232)
1985
30
Hemodynamic and neural mechanisms of acute neurogenic hypertension in the rat. (6507647)
1984
31
Central serotonergic activity after neurogenic hypertension. (6832215)
1983
32
Norepinephrine release and vascular response elicited by nerve stimulation in rats with chronic neurogenic hypertension. (6312017)
1983
33
Neurogenic hypertension after depletion of norepinephrine in anterior hypothalamus induced by 6-hydroxydopamine administration into the ventral pons: role of serotonin. (6405300)
1983
34
Presynaptic dopamine receptor stimulation and the antihypertensive action of pergolide in experimental neurogenic hypertension. (7122527)
1982
35
Naloxone and acute neurogenic hypertension in anaesthetized dogs. (7138086)
1982
36
The nucleus tractus solitarius and experimental neurogenic hypertension: evidence for a central neural imbalance hypothesis of hypertensive disease. (7010944)
1981
37
Aortic histomine syntesis in experimental neurogenic hypertension. (1129333)
1975
38
The central nervous system and neurogenic hypertension. (4600581)
1974
39
Altered norepinephrine synthesis of splanchnic vessels in neurogenic hypertension. (4152768)
1974
40
Effects of p-chlorophenylalanine on blood pressure and heart rate in normal rabbits and rabbits with neurogenic hypertension. (4282070)
1974
41
What is hypertension? Recent studies on neurogenic hypertension. (4929434)
1971
42
Neurogenic hypertension, with special reference to the central neurogenic effects of angiotensin. (4319093)
1970
43
Hemodynamic characteristics of chronic experimental neurogenic hypertension in unanesthetized dogs. (5786795)
1969
44
Aorta wall electrolytes in hypertensive rats. The effect of saline and neurogenic hypertension. (13949962)
1962
45
Arterial hypertension in dogs. II. The effects of neurogenic hypertension with a study of periodic renal biopsies over a seven-year period. (13279130)
1956
46
Experimental psycho-neurogenic hypertension and its treatment with hydrogenated ergot alkaloids (hydergine). (13339143)
1956
47
Role of the adrenals and the hypophysis in experimental neurogenic hypertension. (13305581)
1955
48
Neurogenic hypertension in man in porphyria: transient hypertension and tachycardia caused by disruption of the carotid sinus; review of buffer nerve mechanism. (13170848)
1954
49
The role of the adrenals in experimental neurogenic hypertension. (13093058)
1953
50
Blood Pressure of Renal and of Early and Late Neurogenic Hypertension Dogs after Low Cervical Cord Section. (17858716)
1945

Variations for Neurogenic Hypertension

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Expression for genes affiliated with Neurogenic Hypertension

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Expression patterns in normal tissues for genes affiliated with Neurogenic Hypertension

Search GEO for disease gene expression data for Neurogenic Hypertension.

Pathways for genes affiliated with Neurogenic Hypertension

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Pathways related to Neurogenic Hypertension according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1ENPEP, ACE2
29.0INS, ACE2
3
Show member pathways
8.5ENPEP, ACE2, INS
4
Show member pathways
8.5ENPEP, ACE2, INS

Compounds for genes affiliated with Neurogenic Hypertension

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB
See all sources

Compounds related to Neurogenic Hypertension according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1arginine449.3INS, ENPEP
2alanine449.3INS, ENPEP
3leucine449.2ACE2, ENPEP
4ramipril44 1110.2INS, ACE2
5cholesterol44 28 24 1112.1INS, ACE2
6glutamate449.0INS, ENPEP
7zinc44 2410.0ENPEP, ACE2

GO Terms for genes affiliated with Neurogenic Hypertension

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Biological processes related to Neurogenic Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:0072679.3ENPEP, INS
2angiotensin catabolic process in bloodGO:0020059.2ENPEP, ACE2
3regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.1ACE2, ENPEP
4angiotensin maturationGO:0020039.0ENPEP, ACE2
5cellular protein metabolic processGO:0442678.2ENPEP, ACE2, INS

Products for genes affiliated with Neurogenic Hypertension

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  • Antibodies
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Sources for Neurogenic Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet