MCID: NRG005
MIFTS: 24

Neurogenic Hypertension malady

Neuronal category

Summaries for Neurogenic Hypertension

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33MalaCards
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MalaCards: Neurogenic Hypertension is related to brain compression and cerebral atherosclerosis. An important gene associated with Neurogenic Hypertension is INS (insulin), and among its related pathways are Renin-angiotensin system and Selected targets of HNF1. The compound ramipril have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and kidney.

Aliases & Classifications for Neurogenic Hypertension

Sources:
43NIH Rare Diseases, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

neurogenic hypertension 43 61


Related Diseases for Neurogenic Hypertension

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neurogenic Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1brain compression10.0
2cerebral atherosclerosis10.0
3n syndrome10.0
4atherosclerosis10.0
5kallikrein hypertension10.0
6guillain-barr� syndrome10.0
7hypoxia10.0
8sleep apnea10.0
9antiphospholipid syndrome10.0ENPEP
10diabetic nephropathy10.0INS, ACE2
11proteinuria10.0ACE2, INS
12choriocarcinoma10.0ENPEP
13galactosemia10.0ACE2, INS
14essential hypertension10.0INS, ACE2
15primary hyperoxaluria10.0INS, ACE2
16hypertension10.0ENPEP, ACE2, INS

Graphical network of diseases related to Neurogenic Hypertension:



Diseases related to neurogenic hypertension

Clinical Features for Neurogenic Hypertension

Drugs & Therapeutics for Neurogenic Hypertension

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Neurogenic Hypertension

Drug clinical trials:

Search ClinicalTrials for Neurogenic Hypertension

Search NIH Clinical Center for Neurogenic Hypertension

Search CenterWatch for Neurogenic Hypertension

Genetic Tests for Neurogenic Hypertension

Anatomical Context for Neurogenic Hypertension

Sources:
33MalaCards
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MalaCards organs/tissues related to Neurogenic Hypertension:

33
Spinal cord, Brain, Kidney, Heart, Thyroid, Adrenal gland, Hypothalamus, Pons, Medulla oblongata, Dorsal root ganglion

Animal Models for Neurogenic Hypertension or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Neurogenic Hypertension

Sources:
51PubMed
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Articles related to Neurogenic Hypertension:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Visualizing oxidative stress-induced depression of cardiac vagal baroreflex by MRI/DTI in a mouse neurogenic hypertension model. (23747290)
2013
2
The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension. (24002774)
2013
3
Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice. (24275840)
2013
4
Essential Hypertension: An Approach to Its Etiology and Neurogenic Pathophysiology. (24386559)
2013
5
Neurogenic hypertension: revelations from genome-wide gene expression profiling. (22639016)
2012
6
Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation. (22958438)
2012
7
Coupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension. (21445721)
2011
8
Angiotensin-converting enzyme 2: a new target for neurogenic hypertension. (19923158)
2010
9
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. The kidney is not always the target in neurogenic hypertension. (21188820)
2010
10
Continuous hypertension and tachycardia after resection of a hemangioblastoma behind the dorsal medulla oblongata: relationship to sympathetic overactivity at the neurogenic vasomotor center. (19911894)
2010
11
Is neurogenic hypertension related to vascular inflammation of the brainstem? (18585782)
2009
12
Extracorporeal life support as a treatment for neurogenic pulmonary edema and cardiac failure secondary to intractable intracranial hypertension: a case report and review of the literature. (19088561)
2009
13
Oxidative impairment of mitochondrial electron transport chain complexes in rostral ventrolateral medulla contributes to neurogenic hypertension. (19114648)
2009
14
Specific inflammatory condition in nucleus tractus solitarii of the SHR: novel insight for neurogenic hypertension? (18722165)
2008
15
Compression of the rostral ventrolateral medulla by a vagal schwannoma of the cerebellomedullary cistern presenting with refractory neurogenic hypertension: case report. (16723872)
2006
16
A new model of neurogenic hypertension caused by renal injury: pathophysiology and therapeutic implications. (14586711)
2003
17
Odontoidectomy in the treatment of neurogenic hypertension. Case illustration. (14609179)
2003
18
Neurogenic factors in renal hypertension. (12003710)
2002
19
Losartan reduces central and peripheral sympathetic nerve activity in a rat model of neurogenic hypertension. (12052849)
2002
20
Microvascular decompression of the left lateral medulla oblongata for severe refractory neurogenic hypertension. (9894990)
1999
21
Brainstem compression as a cause of neurogenic hypertension. (10981076)
1999
22
The defense reaction: a common denominator of coronary risk and blood pressure in neurogenic hypertension? (7735282)
1995
23
Lesions in rostral ventromedial or rostral ventrolateral medulla block neurogenic hypertension. (8021014)
1994
24
Neurogenic hypertension. (8421217)
1993
25
Neurogenic hypertension related to basilar impression. Case report. (8246061)
1993
26
Urinary kallikrein excretion in neurogenic hypertension in the dogs: possible relationship between kallikrein excretion and catecholamines. (2692416)
1989
27
Attenuation of neurogenic hypertension by chronic converting enzyme inhibition. (2698949)
1989
28
Relationship between arterial blood pressure and plasma norepinephrine levels in a patient with neurogenic hypertension. (3799645)
1986
29
Circulating and tissue catecholamines in rats with chronic neurogenic hypertension. (3718427)
1986
30
Neurogenic hypertension in the Guillain-BarrAc syndrome. (3903251)
1985
31
Naloxone and acute neurogenic hypertension in anaesthetized dogs. (7138086)
1982
32
The nucleus tractus solitarius and experimental neurogenic hypertension: evidence for a central neural imbalance hypothesis of hypertensive disease. (7010944)
1981
33
Neurogenic hypertension produced by lesions of the nucleus tractus solitarii alone or with sinoaortic denervation in the dog. (7298128)
1981
34
Neurogenic hypertension related to vascular compression of the lateral medulla. (7432603)
1980
35
Neurogenic activity--angiotensin II interaction during the development and maintenance of renal hypertension in the rat. (477245)
1979
36
Plasma catecholamines and neurogenic hypertension. (865556)
1977
37
Influence of diets rich and poor in linoleic acid on renal prostaglandin synthesis in rats with neurogenic hypertension. (1007781)
1976
38
Central serotonergic neurons and experimental neurogenic and renal hypertension in the rabbit. (1077778)
1975
39
The central nervous system and neurogenic hypertension. (4600581)
1974
40
Role of central and peripheral adrenergic mechanisms in neurogenic hypertension produced by brainstem lesions in rat. (4406166)
1974
41
Acute fulminating neurogenic hypertension produced by brainstem lesions in the rat. (4713200)
1973
42
Neurogenic hypertension, with special reference to the central neurogenic effects of angiotensin. (4319093)
1970
43
Aorta wall electrolytes in hypertensive rats. The effect of saline and neurogenic hypertension. (13949962)
1962
44
Experimental psycho-neurogenic hypertension and its treatment with hydrogenated ergot alkaloids (hydergine). (13339143)
1956
45
The effect of dietary sodium-potassium relations on the experimental renal and neurogenic hypertension of the rat. (13372358)
1956
46
Thyroid gland, gonads and experimental neurogenic hypertension. (13262069)
1955
47
Neurogenic hypertension in man in porphyria: transient hypertension and tachycardia caused by disruption of the carotid sinus; review of buffer nerve mechanism. (13170848)
1954
48
The role of the adrenals in experimental neurogenic hypertension. (13093058)
1953
49
Adaptation in the pressor-receptor reflex mechanisms in experimental neurogenic hypertension. (13114417)
1953
50
Blood pressure of renal and of early and late neurogenic hypertension dogs after low cervical cord section. (21005198)
1945

Genetic Variations for Neurogenic Hypertension

Expression for genes affiliated with Neurogenic Hypertension

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurogenic Hypertension

Search GEO for disease gene expression data for Neurogenic Hypertension.

Pathways for genes affiliated with Neurogenic Hypertension

Sources:
30KEGG, 54Reactome, 12EMD Millipore
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Pathways related to Neurogenic Hypertension according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1ENPEP, ACE2
29.0ACE2, INS
3
Hide members
8.5ENPEP, INS, ACE2
4
Hide members
8.5INS, ACE2, ENPEP

Compounds for genes affiliated with Neurogenic Hypertension

Sources:
45Novoseek, 11DrugBank
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Compounds related to Neurogenic Hypertension according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ramipril45 1110.0ACE2, INS

GO Terms for genes affiliated with Neurogenic Hypertension

Sources:
16Gene Ontology
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Biological processes related to Neurogenic Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:0072679.3ENPEP, INS
2angiotensin catabolic process in bloodGO:0020059.2ENPEP, ACE2
3regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.1ENPEP, ACE2
4angiotensin maturationGO:0020039.0ACE2, ENPEP
5cellular protein metabolic processGO:0442678.2ENPEP, ACE2, INS

Products for genes affiliated with Neurogenic Hypertension

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  • Antibodies

Sources for Neurogenic Hypertension

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet