MCID: NRG005
MIFTS: 22

Neurogenic Hypertension malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Neurogenic Hypertension

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Aliases & Descriptions for Neurogenic Hypertension:

Name: Neurogenic Hypertension 45 65


Classifications:



Summaries for Neurogenic Hypertension

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MalaCards based summary: Neurogenic Hypertension is related to neuronitis and cervicitis. An important gene associated with Neurogenic Hypertension is ACE2 (Angiotensin I Converting Enzyme 2), and among its related pathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Affiliated tissues include spinal cord, brain and medulla oblongata.

Related Diseases for Neurogenic Hypertension

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Diseases related to Neurogenic Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1neuronitis10.3
2cervicitis10.3
3cerebritis10.2
4atherosclerosis10.0
5cerebral atherosclerosis10.0
6obstructive sleep apnea10.0
7porphyria10.0
8renal hypertension10.0
9sleep apnea10.0
10thyroiditis10.0
11hypoxia10.0
12hypertension, essential9.8ACE2, ENPEP
13neuroma biliary tract9.7ACE2, ENPEP

Graphical network of diseases related to Neurogenic Hypertension:



Diseases related to neurogenic hypertension

Symptoms for Neurogenic Hypertension

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Drugs & Therapeutics for Neurogenic Hypertension

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Drugs for Neurogenic Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Folic Acidapproved, nutraceuticalPhase 3285159-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
2Vitamin B ComplexPhase 32775
3Vitamin B9NutraceuticalPhase 32851
4Omega 3 Fatty AcidNutraceuticalPhase 3890
5carnitineNutraceuticalPhase 3138
6FolateNutraceuticalPhase 32851
7
Minocyclineapproved, investigationalPhase 1, Phase 216210118-90-85281021
Synonyms:
(2Z,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione
(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE
(4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
10118-90-8
13614-98-7 (mono-hydrochloride)
4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
4708-96-7
7-Dimethylamino-6-demethyl-6-deoxytetracycline
AC1NQXWM
Arestin
BRN 3077644
Bio-0062
Borymycin
C07225
C23H27N3O7
CHEBI:50694
CHEBI:529981
CHEMBL1434
CHEMBL259172
CID5281021
CL 59806
CRL-1605 & Minocycline
D05045
Dynacin
HMS2090D03
HSDB 3130
LMPK07000002
 
LS-93850
Lactoferrin B & Minocycline
Lactoferrin H & Minocycline
MINO
MIY
Minociclina
Minociclina [INN-Spanish]
Minociclinum
Minocin
Minocin (Hydrochloride)
Minocline
Minocyclin
Minocycline
Minocycline (USAN/INN)
Minocycline Hydrochloride
Minocycline Monohydrochloride
Minocycline [USAN:BAN:INN]
Minocyclinum
Minocyclinum [INN-Latin]
NCGC00178854-01
NSC 141993
NSC141993
Solodyn
UNII-FYY3R43WGO
Vectrin (Hydrochloride)
Ximino
minociclinum
minocycline
nchembio.559-comp1

Interventional clinical trials:

idNameStatusNCT IDPhase
1Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in ChildrenRecruitingNCT02192580Phase 3
2L-carnitine on the Prevention of Renal Scarring in Acute PyelonephritisRecruitingNCT02007889Phase 3
3Fesoterodine for Amelioration of Autonomic Dysreflexia (AD) Following Spinal Cord Injury (SCI)RecruitingNCT02676154Phase 2
4Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive PatientsNot yet recruitingNCT02133885Phase 1, Phase 2
5Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive PatientsRecruitingNCT02133872Phase 1
6Study 3: Minocycline Decreases Microglia ActivationNot yet recruitingNCT02213575Phase 1
7Adolescent Blood Pressure Variation and Ventricular MassCompletedNCT00005200
8Brain fMRT In Takotsubo CardiomyopathyRecruitingNCT02240056

Search NIH Clinical Center for Neurogenic Hypertension

Genetic Tests for Neurogenic Hypertension

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Anatomical Context for Neurogenic Hypertension

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MalaCards organs/tissues related to Neurogenic Hypertension:

33
Spinal cord, Brain, Medulla oblongata, Kidney, Hypothalamus, Pons, Thyroid

Animal Models for Neurogenic Hypertension or affiliated genes

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Publications for Neurogenic Hypertension

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Articles related to Neurogenic Hypertension:

(show top 50)    (show all 130)
idTitleAuthorsYear
1
Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. (25489058)
2015
2
Visualizing oxidative stress-induced depression of cardiac vagal baroreflex by MRI/DTI in a mouse neurogenic hypertension model. (23747290)
2013
3
Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension. (24014829)
2013
4
Stabilization of hypoxia inducible factor-1I+ ameliorates acute renal neurogenic hypertension. (24309492)
2013
5
Neurogenic hypertension: revelations from genome-wide gene expression profiling. (22639016)
2012
6
Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link? (22562144)
2012
7
Contributions of vascular inflammation in the brainstem for neurogenic hypertension. (21601658)
2011
8
Coupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension. (21445721)
2011
9
Global identification of the genes and pathways differentially expressed in hypothalamus in early and established neurogenic hypertension. (21487032)
2011
10
Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. (19926873)
2010
11
Inflammation and neurogenic hypertension: a new role for the circumventricular organs? (20651292)
2010
12
Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension. (19762685)
2009
13
Do changes in the coupling between respiratory and sympathetic activities contribute to neurogenic hypertension? (19413588)
2009
14
Is neurogenic hypertension related to vascular inflammation of the brainstem? (18585782)
2009
15
Signalling across the blood brain barrier by angiotensin II: novel implications for neurogenic hypertension. (18443753)
2008
16
Aminopeptidase A: could it be a novel target for neurogenic hypertension? (18362227)
2008
17
Effect of renal injury-induced neurogenic hypertension on NO synthase, caveolin-1, AKt, calmodulin and soluble guanylate cyclase expressions in the kidney. (17122386)
2007
18
Neurovascular compression of the medulla: can it cause neurogenic hypertension? (17215662)
2007
19
Losartan reduces central and peripheral sympathetic nerve activity in a rat model of neurogenic hypertension. (12052849)
2002
20
Unloading arterial baroreceptors causes neurogenic hypertension. (11893608)
2002
21
Microvascular decompression of the left lateral medulla oblongata for severe refractory neurogenic hypertension. (10069614)
1999
22
Microvascular decompression of the left lateral medulla oblongata for severe refractory neurogenic hypertension. (10515496)
1999
23
The defense reaction: a common denominator of coronary risk and blood pressure in neurogenic hypertension? (7735282)
1995
24
Neurogenic hypertension. (8421217)
1993
25
Urinary kallikrein excretion in neurogenic hypertension in the dogs: possible relationship between kallikrein excretion and catecholamines. (2692416)
1989
26
Forebrain mechanisms in neurogenic hypertension. (3690390)
1987
27
Relationship between arterial blood pressure and plasma norepinephrine levels in a patient with neurogenic hypertension. (3799645)
1986
28
Circulating and tissue catecholamines in rats with chronic neurogenic hypertension. (3718427)
1986
29
Neurogenic hypertension: etiology and surgical treatment. II. Observations in an experimental nonhuman primate model. (4015232)
1985
30
Hemodynamic and neural mechanisms of acute neurogenic hypertension in the rat. (6507647)
1984
31
Central serotonergic activity after neurogenic hypertension. (6832215)
1983
32
Norepinephrine release and vascular response elicited by nerve stimulation in rats with chronic neurogenic hypertension. (6312017)
1983
33
Neurogenic hypertension after depletion of norepinephrine in anterior hypothalamus induced by 6-hydroxydopamine administration into the ventral pons: role of serotonin. (6405300)
1983
34
Presynaptic dopamine receptor stimulation and the antihypertensive action of pergolide in experimental neurogenic hypertension. (7122527)
1982
35
Naloxone and acute neurogenic hypertension in anaesthetized dogs. (7138086)
1982
36
The nucleus tractus solitarius and experimental neurogenic hypertension: evidence for a central neural imbalance hypothesis of hypertensive disease. (7010944)
1981
37
Aortic histomine syntesis in experimental neurogenic hypertension. (1129333)
1975
38
The central nervous system and neurogenic hypertension. (4600581)
1974
39
Altered norepinephrine synthesis of splanchnic vessels in neurogenic hypertension. (4152768)
1974
40
Effects of p-chlorophenylalanine on blood pressure and heart rate in normal rabbits and rabbits with neurogenic hypertension. (4282070)
1974
41
What is hypertension? Recent studies on neurogenic hypertension. (4929434)
1971
42
Neurogenic hypertension, with special reference to the central neurogenic effects of angiotensin. (4319093)
1970
43
Hemodynamic characteristics of chronic experimental neurogenic hypertension in unanesthetized dogs. (5786795)
1969
44
Aorta wall electrolytes in hypertensive rats. The effect of saline and neurogenic hypertension. (13949962)
1962
45
Arterial hypertension in dogs. II. The effects of neurogenic hypertension with a study of periodic renal biopsies over a seven-year period. (13279130)
1956
46
Experimental psycho-neurogenic hypertension and its treatment with hydrogenated ergot alkaloids (hydergine). (13339143)
1956
47
Role of the adrenals and the hypophysis in experimental neurogenic hypertension. (13305581)
1955
48
Neurogenic hypertension in man in porphyria: transient hypertension and tachycardia caused by disruption of the carotid sinus; review of buffer nerve mechanism. (13170848)
1954
49
The role of the adrenals in experimental neurogenic hypertension. (13093058)
1953
50
Blood Pressure of Renal and of Early and Late Neurogenic Hypertension Dogs after Low Cervical Cord Section. (17858716)
1945

Variations for Neurogenic Hypertension

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Expression for genes affiliated with Neurogenic Hypertension

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Search GEO for disease gene expression data for Neurogenic Hypertension.

Pathways for genes affiliated with Neurogenic Hypertension

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GO Terms for genes affiliated with Neurogenic Hypertension

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Biological processes related to Neurogenic Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1angiotensin catabolic process in bloodGO:00020059.8ACE2, ENPEP
2regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.8ACE2, ENPEP
3angiotensin maturationGO:00020039.5ACE2, ENPEP
4proteolysisGO:00065089.1ACE2, ENPEP
5cellular protein metabolic processGO:00442678.8ACE2, ENPEP

Molecular functions related to Neurogenic Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metallopeptidase activityGO:00082379.2ACE2, ENPEP
2zinc ion bindingGO:00082709.1ACE2, ENPEP

Sources for Neurogenic Hypertension

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet