MCID: NRL004
MIFTS: 60

Neuroleptic Malignant Syndrome malady

Rare diseases, Neuronal diseases categories
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Summaries for Neuroleptic Malignant Syndrome

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44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Neuroleptic malignant syndrome is a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Symptoms include high fever, sweating, unstable blood pressure, stupor, muscular rigidity, and autonomic dysfunction. In most cases, the disorder develops within the first 2 weeks of treatment with the drug; however, the disorder may develop any time during the therapy period. The syndrome can also occur in people taking anti-Parkinsonism drugs known as dopaminergics if those drugs are discontinued abruptly.

MalaCards: Neuroleptic Malignant Syndrome is related to serotonin syndrome and parkinson's disease. An important gene associated with Neuroleptic Malignant Syndrome is NHLRC1 (NHL repeat containing E3 ubiquitin protein ligase 1), and among its related pathways are Monoamine GPCRs and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds amperozide and mcpp have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and subthalamic nucleus, and related mouse phenotypes are cardiovascular system and nervous system.

Wikipedia:65 Neuroleptic malignant syndrome (NMS) is a life-threatening neurological disorder most often caused by an... more...

Aliases & Classifications for Neuroleptic Malignant Syndrome

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8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
neuroleptic malignant syndrome:
Prevalence: 1-5/10000


Aliases & Descriptions:

neuroleptic malignant syndrome 8 43 44 10 45 49 62


External Ids:

Disease Ontology8 DOID:14464
MeSH35 D009459
ICD9CM27 333.92
MESH via Orphanet36 D009459
ICD10 via Orphanet26 G21.0
SNOMED-CT via Orphanet59 15244003
UMLS via Orphanet63 C0027849

Related Diseases for Neuroleptic Malignant Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Neuroleptic Malignant Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1serotonin syndrome31.1HTR3A, HTR2A, HTR1A
2parkinson's disease30.9DRD2, HTR1A, CYP2D6
3malignant hyperthermia30.7PIK3C2A, RYR1, RYR3, MB
4dementia30.6CYP2D6, PIK3C2A, HTR3A, HTR2A, NHLRC1, HTR1A
5cocaine abuse30.5HTR3A, DRD2
6schizophrenia30.5HTR1A, HTR3A, HTR2A, CHKB, CYP2D6, MB
7bipolar disorder30.5HTR1A, HTR3A, HTR2A, DRD2
8anxiety disorder30.4HTR3A
9amnestic disorder30.3HTR1A, HTR3A
10neuropathy30.3PIK3C2A, MB, RYR1
11generalized anxiety disorder30.3HTR3A, HTR1A, HTR2A
12myocardial infarction30.3CHKA, NPPB, MB, HTR3A, HTR2A, CHKB
13brain disease30.2CPT2, RYR1, GPT
14acute myocardial infarction30.0HTR2A, MB, CHKB, NPPB, PIK3C2A, CHKA
15cerebritis10.5
16brain injury10.4
17cerebral palsy10.4
18cerebellar degeneration10.4
19traumatic brain injury10.4
20burns10.3
21diabetic ketoacidosis10.3
22status epilepticus10.3
23systemic lupus erythematosus10.3
24striatonigral degeneration10.3
25dystonia10.3
26encephalitis10.3
27lupus erythematosus10.3
28malignant hyperthermia susceptibility10.3
29mental retardation10.3
30axonal neuropathy10.1
31paranoid schizophrenia10.1
32diabetes insipidus10.1
33succinic semialdehyde dehydrogenase deficiency10.1
34neuronitis10.1
35adrenoleukodystrophy10.1
36appendicitis10.1
37progressive supranuclear palsy10.1
38viral encephalitis10.1
39pulmonary edema10.1
40huntington's disease10.1
41hypophosphatemia10.1
42stevens-johnson syndrome10.1
43neurogenic bladder10.1
44toxic encephalopathy10.1
45nephrogenic diabetes insipidus10.1
46joubert syndrome10.1
47bipolar i disorder10.1
48cerebral malaria10.1
49basal ganglia disease10.1
50constipation10.1

Graphical network of the top 20 diseases related to Neuroleptic Malignant Syndrome:



Diseases related to neuroleptic malignant syndrome

Symptoms for Neuroleptic Malignant Syndrome

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Drugs & Therapeutics for Neuroleptic Malignant Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Neuroleptic Malignant Syndrome

Search NIH Clinical Center for Neuroleptic Malignant Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Neuroleptic Malignant Syndrome

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Anatomical Context for Neuroleptic Malignant Syndrome

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33MalaCards
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MalaCards organs/tissues related to Neuroleptic Malignant Syndrome:

33
Brain, Liver, Subthalamic nucleus, Tongue

Animal Models for Neuroleptic Malignant Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Neuroleptic Malignant Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.9DRD2, RYR1, NPPB, MB, HTR1A, POMC
2MP:00036317.8NHLRC1, POMC, CHKB, HTR3A, HTR1A, RYR3
3MP:00053697.5RYR3, NPPB, MB, DRD2, HTR3A, HTR2A
4MP:00053867.3DRD2, RYR1, RYR3, HTR1A, HTR3A, HTR2A
5MP:00107687.0RYR1, MB, DRD2, HTR1A, HTR3A, CHKA
6MP:00053766.6F2RL1, PIK3C2A, CHKB, NHLRC1, POMC, CHKA

Publications for Neuroleptic Malignant Syndrome

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52PubMed
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Articles related to Neuroleptic Malignant Syndrome:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Recurrence of neuroleptic malignant syndrome. (24096397)
2013
2
Neuroleptic malignant syndrome associated with risperidone long-acting injection: a case report. (23288234)
2013
3
Neuroleptic malignant syndrome masked by cerebral malaria. (23704432)
2013
4
Lithium toxicity and neurologic effects: probable neuroleptic malignant syndrome resulting from lithium toxicity. (22953147)
2012
5
Comment: Neuroleptic malignant syndrome versus serotonin syndrome: the search for a diagnostic tool. (22414792)
2012
6
Neuroleptic malignant syndrome associated with bromocriptine withdrawal in Parkinson's disease--a case report. (21601731)
2011
7
An unusual case of neuroleptic malignant syndrome. (20160232)
2010
8
Neuroleptic malignant syndrome following levomepromazine discontinuation. (20463130)
2010
9
Neuroleptic malignant syndrome with the addition of aripiprazole to clozapine. (20080143)
2010
10
An unrecognised case of withdrawal neuroleptic malignant syndrome: a case report. (20025106)
2009
11
Olanzapine-induced neuroleptic malignant syndrome in a patient with paranoid schizophrenia. (19067992)
2009
12
Neuroleptic malignant syndrome secondary to quetiapine. (19299325)
2009
13
Neuroleptic malignant syndrome developing after acute overdose with olanzapine and chlorpromazine. (19191213)
2009
14
Catatonia as a risk factor for the development of neuroleptic malignant syndrome: report of a case following treatment with clozapine. (19673089)
2009
15
Neuroleptic malignant syndrome associated with atypical antipsychotics in pediatric patients: a review of published cases. (18572981)
2008
16
A case of 45,XO/47,XYY mosaicism with psychotic symptoms and neuroleptic malignant syndrome. (17478025)
2007
17
Late-onset neuroleptic malignant syndrome in a patient using olanzapine. (17502780)
2007
18
Hypophosphatemia and neuroleptic malignant syndrome. (17502779)
2007
19
Neuroleptic malignant syndrome and serotonin syndrome. (17645916)
2007
20
Neuroleptic malignant syndrome in elderly patients. (17425496)
2007
21
Possible neuroleptic malignant syndrome associated with paliperidone. (18070861)
2007
22
Aripiprazole as the causative agent of neuroleptic malignant syndrome: a case report. (17607339)
2007
23
Zuclopenthixol-induced neuroleptic malignant syndrome in an adolescent girl. (17453880)
2007
24
Intestinal pseudo-obstruction and neuroleptic malignant syndrome in a chronically constipated parkinsonian patient. (16618352)
2006
25
Neuroleptic malignant syndrome with delayed onset of fever following risperidone administration. (17119106)
2006
26
Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child. (17156702)
2006
27
Neuroleptic malignant syndrome: a review and report of six cases. (17214072)
2006
28
A case report of neuroleptic malignant syndrome without fever in a patient given aripiprazole. (17017330)
2006
29
The WHO analgesic ladder and neuroleptic malignant syndrome. (17067339)
2006
30
Early bicarbonate loading and dantroline for ziprasidone/haloperidol-induced neuroleptic malignant syndrome. (16669738)
2006
31
Neuroleptic malignant syndrome after an emergency operation for acute appendicitis perforation. (15646452)
2004
32
Atypical neuroleptic malignant syndrome associated with risperidone treatment in two adolescents. (15266995)
2004
33
Neuroleptic malignant syndrome and atypical antipsychotic drugs. (15119907)
2004
34
Lack of association in Japanese patients between neuroleptic malignant syndrome and the TaqI A polymorphism of the dopamine D2 receptor gene. (12605103)
2003
35
Neuroleptic malignant syndrome following cardiac surgery: successful treatment with dantrolene. (12965323)
2003
36
Risk factors in neuroleptic malignant syndrome. A case-control study. (12558541)
2003
37
Neuroleptic malignant syndrome and low-dose olanzapine. (12668376)
2003
38
Neuroleptic malignant syndrome: uncommon postoperative diagnostic dilemma. (12538292)
2002
39
Persistent fever in a case of typhoid--an unusual cause of neuroleptic malignant syndrome. (11225156)
2001
40
Three patients with isolated adrenocorticotropin deficiency presenting with neuroleptic malignant syndrome-like symptoms. (11446676)
2001
41
Neuroleptic malignant syndrome in pregnancy. (11704197)
2001
42
Neuroleptic malignant syndrome after venlafaxine. (10675082)
2000
43
Neuroleptic malignant syndrome: a diagnosis easily missed. (11072926)
2000
44
CYP2D6 HhaI genotype and the neuroleptic malignant syndrome. (9892857)
1999
45
Electroconvulsive therapy for the treatment of neuroleptic malignant syndrome with psychotic symptoms: a report of five cases. (10378156)
1999
46
"Multiple ECT" for neuroleptic malignant syndrome. (10614039)
1999
47
Clozapine-induced neuroleptic malignant syndrome: an interaction between dopaminergic and purinergic systems? (10512095)
1999
48
Ecstasy intoxication: an overlap between serotonin syndrome and neuroleptic malignant syndrome. (8777769)
1996
49
The role of creatine kinase in the diagnosis of neuroleptic malignant syndrome. (8101383)
1993
50
Cerebellar degeneration in neuroleptic malignant syndrome: neuropathologic findings and review of the literature concerning heat-related nervous system injury. (2647908)
1989

Variations for Neuroleptic Malignant Syndrome

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Expression for genes affiliated with Neuroleptic Malignant Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroleptic Malignant Syndrome

Search GEO for disease gene expression data for Neuroleptic Malignant Syndrome.

Pathways for genes affiliated with Neuroleptic Malignant Syndrome

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 51PharmGKB, 30KEGG, 53QIAGEN
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Pathways related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6HTR2A, HTR1A, DRD2
29.6HTR3A, HTR2A, HTR1A
39.6HTR2A, HTR3A, HTR1A
4
Show member pathways
9.2RYR1, HTR3A, RYR3
5
Show member pathways
8.9POMC, HTR2A, HTR1A, DRD2, F2RL1
6
Show member pathways
8.9PIK3C2A, CHKA, CHKB
7
Show member pathways
8.6HTR2A, RYR3, RYR1, HTR1A, HTR3A
8
Show member pathways
8.1CYP2D6, RYR3, RYR1, DRD2, HTR1A, HTR3A
9
Show member pathways
7.3NHLRC1, GPT, CPT2, POMC, CHKA, CHKB

Compounds for genes affiliated with Neuroleptic Malignant Syndrome

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 338)
idCompoundScoreTop Affiliating Genes
1amperozide459.7HTR3A, DRD2, HTR2A, HTR1A
2mcpp459.7HTR1A, CYP2D6, HTR2A, HTR3A
3piperazine45 1110.7DRD2, HTR1A, CYP2D6, HTR2A
4granisetron51 45 1111.7HTR2A, CYP2D6, DRD2, HTR3A
5pindolol45 29 1111.7HTR1A, HTR2A, HTR3A, CYP2D6
6trimipramine45 51 1111.6HTR2A, HTR1A, CYP2D6, DRD2
7spiperone45 2910.6DRD2, HTR1A, HTR3A, HTR2A
8sertindole29 45 1111.6DRD2, HTR1A, HTR2A, CYP2D6
9antipsychotics519.6ANKK1, HTR2A, DRD2, CYP2D6
10ritanserin45 2910.6HTR1A, DRD2, HTR3A, HTR2A
11buspirone45 29 1111.5HTR2A, HTR1A, HTR3A, DRD2, CYP2D6
12ipsapirone45 2910.5HTR3A, POMC, HTR2A, HTR1A
13iloperidone51 45 29 1112.5HTR2A, CYP2D6, HTR3A, DRD2, HTR1A
14aripiprazole29 45 51 24 1113.5HTR3A, HTR1A, DRD2, HTR2A, CYP2D6
15ziprasidone29 51 45 1112.5DRD2, HTR2A, CYP2D6, HTR1A, HTR3A
16yohimbine45 3 29 1112.5HTR2A, CYP2D6, DRD2, HTR1A, HTR3A
17quetiapine45 51 29 24 1113.5CYP2D6, HTR2A, DRD2, HTR1A, HTR3A
18pimozide29 45 51 1112.4HTR1A, HTR2A, CYP2D6, DRD2
19lisuride45 29 1111.4DRD2, HTR2A, CYP2D6, HTR1A
20fluoxetine45 51 29 1112.4CYP2D6, HTR2A, HTR3A, HTR1A, DRD2
21nefazodone45 51 1111.4CYP2D6, HTR2A, HTR3A, HTR1A
22fenfluramine45 29 1111.3HTR1A, HTR2A, POMC, CYP2D6, HTR3A
23ropinirole45 1110.3CYP2D6, HTR2A, HTR1A, DRD2
24chlorpromazine29 45 51 1112.3CHKB, DRD2, HTR2A, HTR3A, HTR1A, CYP2D6
25alpha-hydroxybutyrate459.1CHKB, GPT, PIK3C2A, MB
26succinylcholine45 51 29 1112.1RYR1, MB, PIK3C2A, CHKB
27olanzapine45 51 29 24 1113.0DRD2, HTR2A, CYP2D6, CHKB, HTR1A, HTR3A
28halothane45 51 29 1111.9CYP2D6, RYR1, CHKB, MB, PIK3C2A
29maoa458.9POMC, HTR2A, HTR1A, DRD2
305-hydroxytryptamine458.9HTR2A, HTR3A, HTR1A, DRD2, F2RL1, POMC
31bromocriptine45 29 1110.7POMC, PIK3C2A, HTR2A, HTR1A, DRD2
32dantrolene29 45 1110.6PIK3C2A, RYR3, RYR1, CHKB, MB
33fluvastatin45 51 29 1111.6PIK3C2A, CYP2D6, GPT, MB, CHKB
34risperidone45 51 29 61 24 1113.6CYP2D6, HTR1A, HTR3A, GPT, CHKB, ANKK1
35citrate458.3PIK3C2A, MB, CPT2, POMC, CHKA, CHKB
36cocaine45 119.3CYP2D6, GPT, MB, POMC, DRD2, PIK3C2A
37prednisolone45 29 1110.2NPPB, MB, CHKB, POMC, GPT, PIK3C2A
38pravastatin45 51 29 24 1112.1PIK3C2A, CYP2D6, CHKB, NPPB, GPT, CHKA
39atorvastatin45 51 29 24 1112.1GPT, CYP2D6, CHKA, CHKB, NPPB, PIK3C2A
40adenylate457.9DRD2, POMC, CHKA, CHKB, HTR3A, HTR1A
41clozapine45 29 51 1110.9ANKK1, DRD2, HTR1A, HTR3A, HTR2A, CHKB
42dopamine45 29 24 1110.8DRD2, NPPB, F2RL1, CYP2D6, POMC, CHKB
43thyroxine45 248.7POMC, CHKA, GPT, CHKB, MB, NPPB
44glycogen45 248.7PIK3C2A, NHLRC1, CHKB, NPPB, GPT, CPT2
45glutamate457.4CHKA, F2RL1, RYR1, MB, DRD2, CHKB
46haloperidol45 51 29 3 1111.1HTR3A, NPPB, MB, DRD2, HTR1A, HTR2A
47creatinine457.1CHKA, POMC, CHKB, MB, NPPB, RYR1
48norepinephrine45 24 118.9HTR3A, HTR2A, CHKB, POMC, F2RL1, HTR1A
49acetylcholine45 51 29 24 1110.7HTR1A, HTR3A, CHKA, POMC, CYP2D6, PIK3C2A
50glucose456.7POMC, F2RL1, PIK3C2A, GPT, CPT2, RYR1

GO Terms for genes affiliated with Neuroleptic Malignant Syndrome

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16Gene Ontology
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Cellular components related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.5DRD2, HTR3A, HTR2A
2junctional membrane complexGO:0303149.4RYR1, RYR3
3integral component of plasma membraneGO:0058878.4RYR1, F2RL1, HTR2A, HTR3A, HTR1A, DRD2

Biological processes related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.2HTR1A, HTR2A
2negative regulation of synaptic transmission, glutamatergicGO:05196710.1HTR2A, DRD2
3regulation of behaviorGO:05079510.1HTR2A, HTR1A
4behavioral response to cocaineGO:04814810.1DRD2, HTR2A
5CDP-choline pathwayGO:00665710.0CHKA, CHKB
6temperature homeostasisGO:0016599.9DRD2, HTR2A
7positive regulation of urine volumeGO:0358109.9DRD2, NPPB
8phosphatidylethanolamine biosynthetic processGO:0066469.9CHKA, CHKB
9negative regulation of cytosolic calcium ion concentrationGO:0514819.9RYR3, DRD2
10serotonin receptor signaling pathwayGO:0072109.9HTR1A, HTR3A, HTR2A
11release of sequestered calcium ion into cytosolGO:0512099.8HTR2A, DRD2, RYR1
12positive regulation of renal sodium excretionGO:0358159.8DRD2, NPPB
13positive regulation of ERK1 and ERK2 cascadeGO:0703749.8F2RL1, HTR2A, DRD2
14cellular response to caffeineGO:0713139.8RYR3, RYR1
15phosphatidylcholine biosynthetic processGO:0066569.7CHKA, CHKB
16response to hypoxiaGO:0016669.6MB, RYR1, DRD2
17response to cocaineGO:0422209.6DRD2, HTR3A
18phospholipid metabolic processGO:0066448.8PIK3C2A, CHKB, CHKA
19small molecule metabolic processGO:0442818.1NHLRC1, GPT, CPT2, CHKB, CYP2D6, PIK3C2A

Molecular functions related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1choline kinase activityGO:0041039.8CHKA, CHKB
2G-protein alpha-subunit bindingGO:0019659.8F2RL1, HTR2A
3ethanolamine kinase activityGO:0043059.8CHKB, CHKA
4serotonin receptor activityGO:0049939.7HTR3A, HTR1A, HTR2A
5ryanodine-sensitive calcium-release channel activityGO:0052199.5RYR1, RYR3
6serotonin bindingGO:0513789.5HTR3A, HTR2A
7calcium-release channel activityGO:0152789.4RYR1, RYR3
8drug bindingGO:0081449.3DRD2, CYP2D6, HTR2A, CHKA

Products for genes affiliated with Neuroleptic Malignant Syndrome

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Sources for Neuroleptic Malignant Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet