MCID: NRL004
MIFTS: 61

Neuroleptic Malignant Syndrome malady

Rare diseases, Neuronal diseases categories
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Summaries for Neuroleptic Malignant Syndrome

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NINDS:43 Neuroleptic malignant syndrome is a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Symptoms include high fever, sweating, unstable blood pressure, stupor, muscular rigidity, and autonomic dysfunction. In most cases, the disorder develops within the first 2 weeks of treatment with the drug; however, the disorder may develop any time during the therapy period. The syndrome can also occur in people taking anti-Parkinsonism drugs known as dopaminergics if those drugs are discontinued abruptly.

MalaCards based summary: Neuroleptic Malignant Syndrome is related to serotonin syndrome and parkinson's disease. An important gene associated with Neuroleptic Malignant Syndrome is NHLRC1 (NHL repeat containing E3 ubiquitin protein ligase 1), and among its related pathways are Monoamine GPCRs and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds amperozide and mcpp have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and breast, and related mouse phenotypes are cardiovascular system and nervous system.

Wikipedia:65 Neuroleptic malignant syndrome (NMS) is a life-threatening neurological disorder most often caused by an... more...

Aliases & Classifications for Neuroleptic Malignant Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 27ICD9CM, 57SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Neuroleptic Malignant Syndrome, Aliases & Descriptions:

Name: Neuroleptic Malignant Syndrome 8 42 43 10 44 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
neuroleptic malignant syndrome:
Prevalence: 1-5/10000


External Ids:

Disease Ontology8 DOID:14464
ICD9CM27 333.92
MeSH34 D009459
MESH via Orphanet35 D009459
ICD10 via Orphanet26 G21.0
UMLS via Orphanet63 C0027849

Related Diseases for Neuroleptic Malignant Syndrome

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Diseases related to Neuroleptic Malignant Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1serotonin syndrome31.4HTR1A, HTR3A, HTR2A
2parkinson's disease31.3CYP2D6, HTR1A, DRD2
3anxiety disorder31.0HTR3A
4cocaine abuse31.0HTR3A, DRD2
5malignant hyperthermia30.9PIK3C2A, MB, RYR1, RYR3
6amnestic disorder30.7HTR1A, HTR3A
7dementia30.6PIK3C2A, CYP2D6, NHLRC1, HTR2A, HTR3A, HTR1A
8neuropathy30.6RYR1, MB, PIK3C2A
9bipolar disorder30.6HTR2A, HTR3A, HTR1A, DRD2
10generalized anxiety disorder30.5HTR2A, HTR3A, HTR1A
11brain disease30.3GPT, CPT2, RYR1
12schizophrenia30.2F2RL1, CYP2D6, CHKB, HTR2A, HTR3A, HTR1A
13myocardial infarction29.8PIK3C2A, CHKA, CHKB, HTR2A, HTR3A, MB
14acute myocardial infarction29.5PIK3C2A, CHKA, CHKB, HTR2A, HTR3A, MB
15gas gangrene10.5PIK3C2A
16cardiac rupture10.5CHKB
17cerebritis10.5
18premature ejaculation10.5HTR1A
19carnitine palmitoyltransferase ii deficiency10.5CPT2
20pathological gambling10.5DRD2
21status asthmaticus10.5PIK3C2A
22encephalitis10.5
23pericardial effusion10.5PIK3C2A, CHKB
24alexithymia10.5ANKK1
25brain injury10.4
26central core myopathy10.4RYR3
27intermediate coronary syndrome10.4PIK3C2A, MB
28ectopic pregnancy10.4PIK3C2A, CHKB
29hypokalemic periodic paralysis10.4RYR1
30glycogen storage disease v10.4CHKB, CPT2
31heroin dependence10.4ANKK1, DRD2
32motion sickness10.4HTR3A, HTR1A
33creatine phosphokinase, elevated serum10.4PIK3C2A, CHKB, MB
34cerebral palsy10.4
35traumatic brain injury10.4
36cerebellar degeneration10.4
37restless legs syndrome10.4HTR3A, DRD2
38seasonal affective disorder10.4HTR2A, HTR1A
39coronary artery vasospasm10.4CHKB, HTR2A
40metabolic acidosis10.4PIK3C2A, CHKB, MB
41duchenne muscular dystrophy10.4MB, CHKB, PIK3C2A
42compartment syndrome10.4CHKA, CHKB, MB
43social phobia10.3HTR3A, HTR1A, DRD2
44myotonic dystrophy10.3RYR1, CHKB, PIK3C2A
45burns10.3
46huntington's disease10.3
47systemic lupus erythematosus10.3
48diabetic ketoacidosis10.3
49status epilepticus10.3
50striatonigral degeneration10.3

Graphical network of the top 20 diseases related to Neuroleptic Malignant Syndrome:



Diseases related to neuroleptic malignant syndrome

Symptoms for Neuroleptic Malignant Syndrome

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Drugs & Therapeutics for Neuroleptic Malignant Syndrome

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Drug clinical trials:

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Search NIH Clinical Center for Neuroleptic Malignant Syndrome

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Neuroleptic Malignant Syndrome

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Anatomical Context for Neuroleptic Malignant Syndrome

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MalaCards organs/tissues related to Neuroleptic Malignant Syndrome:

32
Brain, Liver, Breast, Subthalamic nucleus, Tongue

Animal Models for Neuroleptic Malignant Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Neuroleptic Malignant Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.9F2RL1, POMC, HTR1A, DRD2, MB, NPPB
2MP:00036317.8F2RL1, NHLRC1, POMC, CHKB, HTR3A, HTR1A
3MP:00053697.5RYR3, NHLRC1, CHKB, HTR2A, HTR3A, DRD2
4MP:00053867.3F2RL1, NHLRC1, POMC, CHKB, HTR2A, HTR3A
5MP:00107687.0PIK3C2A, POMC, CHKA, HTR3A, HTR1A, DRD2
6MP:00053766.6POMC, NHLRC1, PIK3C2A, F2RL1, CHKA, CHKB

Publications for Neuroleptic Malignant Syndrome

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Articles related to Neuroleptic Malignant Syndrome:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Recurrence of neuroleptic malignant syndrome. (24096397)
2013
2
Neuroleptic malignant syndrome associated with risperidone long-acting injection: a case report. (23288234)
2013
3
Neuroleptic malignant syndrome masked by cerebral malaria. (23704432)
2013
4
Lithium toxicity and neurologic effects: probable neuroleptic malignant syndrome resulting from lithium toxicity. (22953147)
2012
5
Comment: Neuroleptic malignant syndrome versus serotonin syndrome: the search for a diagnostic tool. (22414792)
2012
6
Neuroleptic malignant syndrome associated with bromocriptine withdrawal in Parkinson's disease--a case report. (21601731)
2011
7
An unusual case of neuroleptic malignant syndrome. (20160232)
2010
8
Neuroleptic malignant syndrome following levomepromazine discontinuation. (20463130)
2010
9
Neuroleptic malignant syndrome with the addition of aripiprazole to clozapine. (20080143)
2010
10
An unrecognised case of withdrawal neuroleptic malignant syndrome: a case report. (20025106)
2009
11
Olanzapine-induced neuroleptic malignant syndrome in a patient with paranoid schizophrenia. (19067992)
2009
12
Neuroleptic malignant syndrome secondary to quetiapine. (19299325)
2009
13
Neuroleptic malignant syndrome developing after acute overdose with olanzapine and chlorpromazine. (19191213)
2009
14
Catatonia as a risk factor for the development of neuroleptic malignant syndrome: report of a case following treatment with clozapine. (19673089)
2009
15
Neuroleptic malignant syndrome associated with atypical antipsychotics in pediatric patients: a review of published cases. (18572981)
2008
16
A case of 45,XO/47,XYY mosaicism with psychotic symptoms and neuroleptic malignant syndrome. (17478025)
2007
17
Late-onset neuroleptic malignant syndrome in a patient using olanzapine. (17502780)
2007
18
Hypophosphatemia and neuroleptic malignant syndrome. (17502779)
2007
19
Neuroleptic malignant syndrome and serotonin syndrome. (17645916)
2007
20
Neuroleptic malignant syndrome in elderly patients. (17425496)
2007
21
Possible neuroleptic malignant syndrome associated with paliperidone. (18070861)
2007
22
Aripiprazole as the causative agent of neuroleptic malignant syndrome: a case report. (17607339)
2007
23
Zuclopenthixol-induced neuroleptic malignant syndrome in an adolescent girl. (17453880)
2007
24
Intestinal pseudo-obstruction and neuroleptic malignant syndrome in a chronically constipated parkinsonian patient. (16618352)
2006
25
Neuroleptic malignant syndrome with delayed onset of fever following risperidone administration. (17119106)
2006
26
Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child. (17156702)
2006
27
Neuroleptic malignant syndrome: a review and report of six cases. (17214072)
2006
28
A case report of neuroleptic malignant syndrome without fever in a patient given aripiprazole. (17017330)
2006
29
The WHO analgesic ladder and neuroleptic malignant syndrome. (17067339)
2006
30
Early bicarbonate loading and dantroline for ziprasidone/haloperidol-induced neuroleptic malignant syndrome. (16669738)
2006
31
Neuroleptic malignant syndrome after an emergency operation for acute appendicitis perforation. (15646452)
2004
32
Atypical neuroleptic malignant syndrome associated with risperidone treatment in two adolescents. (15266995)
2004
33
Neuroleptic malignant syndrome and atypical antipsychotic drugs. (15119907)
2004
34
Lack of association in Japanese patients between neuroleptic malignant syndrome and the TaqI A polymorphism of the dopamine D2 receptor gene. (12605103)
2003
35
Neuroleptic malignant syndrome following cardiac surgery: successful treatment with dantrolene. (12965323)
2003
36
Risk factors in neuroleptic malignant syndrome. A case-control study. (12558541)
2003
37
Neuroleptic malignant syndrome and low-dose olanzapine. (12668376)
2003
38
Neuroleptic malignant syndrome: uncommon postoperative diagnostic dilemma. (12538292)
2002
39
Persistent fever in a case of typhoid--an unusual cause of neuroleptic malignant syndrome. (11225156)
2001
40
Three patients with isolated adrenocorticotropin deficiency presenting with neuroleptic malignant syndrome-like symptoms. (11446676)
2001
41
Neuroleptic malignant syndrome in pregnancy. (11704197)
2001
42
Neuroleptic malignant syndrome after venlafaxine. (10675082)
2000
43
Neuroleptic malignant syndrome: a diagnosis easily missed. (11072926)
2000
44
CYP2D6 HhaI genotype and the neuroleptic malignant syndrome. (9892857)
1999
45
Electroconvulsive therapy for the treatment of neuroleptic malignant syndrome with psychotic symptoms: a report of five cases. (10378156)
1999
46
"Multiple ECT" for neuroleptic malignant syndrome. (10614039)
1999
47
Clozapine-induced neuroleptic malignant syndrome: an interaction between dopaminergic and purinergic systems? (10512095)
1999
48
Ecstasy intoxication: an overlap between serotonin syndrome and neuroleptic malignant syndrome. (8777769)
1996
49
The role of creatine kinase in the diagnosis of neuroleptic malignant syndrome. (8101383)
1993
50
Cerebellar degeneration in neuroleptic malignant syndrome: neuropathologic findings and review of the literature concerning heat-related nervous system injury. (2647908)
1989

Variations for Neuroleptic Malignant Syndrome

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Expression for genes affiliated with Neuroleptic Malignant Syndrome

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Expression patterns in normal tissues for genes affiliated with Neuroleptic Malignant Syndrome

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Pathways for genes affiliated with Neuroleptic Malignant Syndrome

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Pathways related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6HTR2A, HTR1A, DRD2
29.6HTR3A, HTR2A, HTR1A
39.6HTR2A, HTR3A, HTR1A
4
Show member pathways
9.2RYR1, HTR3A, RYR3
5
Show member pathways
8.9POMC, HTR2A, HTR1A, DRD2, F2RL1
6
Show member pathways
8.9PIK3C2A, CHKA, CHKB
7
Show member pathways
8.6HTR2A, RYR3, RYR1, HTR1A, HTR3A
8
Show member pathways
8.1CYP2D6, RYR3, RYR1, DRD2, HTR1A, HTR3A
9
Show member pathways
7.3NHLRC1, GPT, CPT2, POMC, CHKA, CHKB

Compounds for genes affiliated with Neuroleptic Malignant Syndrome

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Compounds related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 338)
idCompoundScoreTop Affiliating Genes
1amperozide449.7HTR3A, DRD2, HTR2A, HTR1A
2mcpp449.7HTR1A, CYP2D6, HTR2A, HTR3A
3piperazine44 1110.7HTR2A, HTR1A, DRD2, CYP2D6
4granisetron50 44 1111.7HTR2A, CYP2D6, DRD2, HTR3A
5pindolol44 28 1111.7HTR2A, HTR3A, CYP2D6, HTR1A
6trimipramine44 50 1111.6CYP2D6, DRD2, HTR2A, HTR1A
7spiperone44 2810.6HTR3A, DRD2, HTR1A, HTR2A
8sertindole28 44 1111.6HTR1A, HTR2A, CYP2D6, DRD2
9antipsychotics509.6ANKK1, HTR2A, DRD2, CYP2D6
10ritanserin44 2810.6HTR2A, HTR3A, DRD2, HTR1A
11buspirone44 28 1111.5HTR2A, HTR1A, HTR3A, DRD2, CYP2D6
12ipsapirone44 2810.5HTR3A, POMC, HTR2A, HTR1A
13iloperidone50 44 28 1112.5HTR2A, CYP2D6, HTR3A, DRD2, HTR1A
14aripiprazole28 44 50 24 1113.5HTR3A, HTR1A, DRD2, HTR2A, CYP2D6
15ziprasidone28 50 44 1112.5DRD2, HTR2A, CYP2D6, HTR1A, HTR3A
16yohimbine44 2 28 1112.5HTR2A, CYP2D6, DRD2, HTR1A, HTR3A
17quetiapine44 50 28 24 1113.5CYP2D6, HTR2A, DRD2, HTR1A, HTR3A
18thioridazine28 44 50 1112.4CYP2D6, DRD2, HTR2A, HTR1A
19nefazodone44 50 1111.4HTR3A, HTR2A, CYP2D6, HTR1A
20fluoxetine44 50 28 1112.4DRD2, CYP2D6, HTR2A, HTR3A, HTR1A
21fenfluramine44 28 1111.3HTR1A, HTR2A, POMC, CYP2D6, HTR3A
22pimozide28 44 50 1112.3HTR1A, CYP2D6, HTR2A, DRD2
23chlorpromazine28 44 50 1112.3CHKB, DRD2, HTR2A, HTR3A, HTR1A, CYP2D6
24maoa449.2HTR1A, POMC, HTR2A, DRD2
25alpha-hydroxybutyrate449.1CHKB, GPT, PIK3C2A, MB
26ropinirole44 1110.1DRD2, HTR1A, HTR2A, CYP2D6
27succinylcholine44 50 28 1112.1PIK3C2A, RYR1, MB, CHKB
28olanzapine44 50 28 24 1113.0DRD2, HTR2A, CYP2D6, CHKB, HTR1A, HTR3A
29halothane44 50 28 1111.9RYR1, MB, CHKB, CYP2D6, PIK3C2A
305-hydroxytryptamine448.9POMC, DRD2, HTR2A, HTR3A, HTR1A, F2RL1
31bromocriptine44 28 1110.7POMC, DRD2, PIK3C2A, HTR2A, HTR1A
32dantrolene28 44 1110.6PIK3C2A, RYR3, RYR1, CHKB, MB
33fluvastatin44 50 28 1111.6CYP2D6, PIK3C2A, MB, CHKB, GPT
34risperidone44 50 28 61 24 1113.6CYP2D6, HTR1A, HTR3A, GPT, CHKB, ANKK1
35citrate448.3CPT2, PIK3C2A, CHKB, MB, CHKA, POMC
36cocaine44 119.3CYP2D6, GPT, MB, POMC, DRD2, PIK3C2A
37prednisolone44 28 1110.2NPPB, MB, CHKB, POMC, GPT, PIK3C2A
38pravastatin44 50 28 24 1112.1PIK3C2A, CYP2D6, CHKB, NPPB, GPT, CHKA
39atorvastatin44 50 28 24 1112.1GPT, CYP2D6, CHKA, CHKB, NPPB, PIK3C2A
40adenylate447.9DRD2, POMC, CHKA, CHKB, HTR3A, HTR1A
41clozapine44 28 50 1110.9ANKK1, DRD2, HTR1A, HTR3A, HTR2A, CHKB
42dopamine44 28 24 1110.8DRD2, NPPB, F2RL1, CYP2D6, POMC, CHKB
43thyroxine44 248.7POMC, CHKA, GPT, CHKB, MB, NPPB
44glycogen44 248.7NHLRC1, NPPB, CHKB, PIK3C2A, GPT, CPT2
45glutamate447.4CHKA, F2RL1, RYR1, MB, DRD2, CHKB
46haloperidol44 50 28 2 1111.1HTR3A, NPPB, MB, DRD2, HTR1A, HTR2A
47creatinine447.1CHKA, POMC, CHKB, MB, NPPB, RYR1
48norepinephrine44 24 118.9HTR3A, HTR2A, CHKB, POMC, F2RL1, HTR1A
49acetylcholine44 50 28 24 1110.7HTR1A, HTR3A, CHKA, POMC, CYP2D6, PIK3C2A
50glucose446.7F2RL1, PIK3C2A, GPT, CPT2, POMC, CHKA

GO Terms for genes affiliated with Neuroleptic Malignant Syndrome

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Cellular components related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.5DRD2, HTR3A, HTR2A
2junctional membrane complexGO:0303149.4RYR3, RYR1
3integral component of plasma membraneGO:0058878.4F2RL1, HTR2A, HTR3A, HTR1A, DRD2, RYR1

Biological processes related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.2HTR1A, HTR2A
2negative regulation of synaptic transmission, glutamatergicGO:05196710.1DRD2, HTR2A
3regulation of behaviorGO:05079510.1HTR1A, HTR2A
4behavioral response to cocaineGO:04814810.1DRD2, HTR2A
5CDP-choline pathwayGO:00665710.0CHKA, CHKB
6temperature homeostasisGO:0016599.9HTR2A, DRD2
7positive regulation of urine volumeGO:0358109.9DRD2, NPPB
8phosphatidylethanolamine biosynthetic processGO:0066469.9CHKB, CHKA
9negative regulation of cytosolic calcium ion concentrationGO:0514819.9RYR3, DRD2
10serotonin receptor signaling pathwayGO:0072109.9HTR1A, HTR3A, HTR2A
11release of sequestered calcium ion into cytosolGO:0512099.8HTR2A, DRD2, RYR1
12positive regulation of renal sodium excretionGO:0358159.8NPPB, DRD2
13cellular response to caffeineGO:0713139.8RYR1, RYR3
14positive regulation of ERK1 and ERK2 cascadeGO:0703749.8F2RL1, HTR2A, DRD2
15phosphatidylcholine biosynthetic processGO:0066569.7CHKB, CHKA
16response to hypoxiaGO:0016669.6RYR1, MB, DRD2
17response to cocaineGO:0422209.6DRD2, HTR3A
18phospholipid metabolic processGO:0066448.8PIK3C2A, CHKA, CHKB
19small molecule metabolic processGO:0442818.1PIK3C2A, CYP2D6, NHLRC1, GPT, CPT2, CHKA

Molecular functions related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1choline kinase activityGO:0041039.8CHKB, CHKA
2G-protein alpha-subunit bindingGO:0019659.8HTR2A, F2RL1
3ethanolamine kinase activityGO:0043059.8CHKA, CHKB
4serotonin receptor activityGO:0049939.7HTR2A, HTR3A, HTR1A
5ryanodine-sensitive calcium-release channel activityGO:0052199.5RYR3, RYR1
6serotonin bindingGO:0513789.5HTR3A, HTR2A
7calcium-release channel activityGO:0152789.4RYR3, RYR1
8drug bindingGO:0081449.3DRD2, HTR2A, CHKA, CYP2D6

Products for genes affiliated with Neuroleptic Malignant Syndrome

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Sources for Neuroleptic Malignant Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet