MCID: NRL004
MIFTS: 58

Neuroleptic Malignant Syndrome malady

Neuronal diseases category

Summaries for Neuroleptic Malignant Syndrome

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Neuroleptic malignant syndrome is a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Symptoms include high fever, sweating, unstable blood pressure, stupor, muscular rigidity, and autonomic dysfunction. In most cases, the disorder develops within the first 2 weeks of treatment with the drug; however, the disorder may develop any time during the therapy period. The syndrome can also occur in people taking anti-Parkinsonism drugs known as dopaminergics if those drugs are discontinued abruptly.

MalaCards: Neuroleptic Malignant Syndrome is related to malignant hyperthermia and parkinson's disease. An important gene associated with Neuroleptic Malignant Syndrome is NHLRC1 (NHL repeat containing 1), and among its related pathways are Codeine and morphine metabolism and Monoamine GPCRs. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds Pipotiazine and amperozide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and subthalamic nucleus, and related mouse phenotypes are muscle and behavior/neurological.

Wikipedia:63 Neuroleptic malignant syndrome (NMS) is a life-threatening neurological disorder most often caused by an... more...

Aliases & Classifications for Neuroleptic Malignant Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
neuroleptic malignant syndrome:
Prevalence: 1-5/10000


Aliases & Descriptions:

neuroleptic malignant syndrome 8 42 43 10 44 48 60


External Ids:

Disease Ontology8 DOID:14464
ICD9CM27 333.92
MeSH34 D009459
MESH via Orphanet35 D009459
ICD10 via Orphanet26 G21.0
SNOMED-CT via Orphanet57 15244003
UMLS via Orphanet61 C0027849

Related Diseases for Neuroleptic Malignant Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Neuroleptic Malignant Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1malignant hyperthermia30.8MB, PIK3C2A, RYR1, RYR3
2parkinson's disease30.8HTR1A, HTR3A, HTR2A, DRD2, CHKB, CYP2D6
3dementia30.5HTR1A, HTR3A, HTR2A, PIK3C2A, CYP2D6, NHLRC1
4schizophrenia30.5MB, HTR1A, HTR3A, HTR2A, DRD2, CHKB
5bipolar disorder30.5HTR1A, HTR3A, HTR2A, DRD2
6malignant hyperthermia susceptibility30.3RYR1
7cocaine abuse30.3HTR3A, DRD2
8myocardial infarction30.3MB, HTR3A, HTR2A, NPPB, PIK3C2A, CHKA
9anxiety disorder30.1HTR3A
10hyperglycemia30.1POMC
11diarrhea30.1HTR3A
12disseminated intravascular coagulation30.1MB, PIK3C2A
13neuropathy30.1RYR1, PIK3C2A, MB
14amnestic disorder30.1HTR1A, HTR3A
15generalized anxiety disorder30.1HTR1A, HTR3A, HTR2A
16epilepsy syndrome30.1NHLRC1, CYP2D6, HTR3A, HTR1A
17pneumonia30.1PIK3C2A, MB
18brain disease30.1RYR1, GPT, CPT2
19acute myocardial infarction30.1MB, HTR3A, HTR2A, NPPB, PIK3C2A, CHKA
20cerebritis10.5
21lewy body dementia10.3
22cerebral palsy10.3
23burns10.2
24status epilepticus10.2
25diabetic ketoacidosis10.2
26systemic lupus erythematosus10.2
27striatonigral degeneration10.2
28typhoid fever10.2
29encephalitis10.2
30lupus erythematosus10.2
31syndromic diarrhea10.1
32axonal neuropathy10.1
33paranoid schizophrenia10.1
34pulmonary edema10.1
35huntington's disease10.1
36hypophosphatemia10.1
37stevens-johnson syndrome10.1
38neurogenic bladder10.1
39toxic encephalopathy10.1
40diabetes insipidus10.1
41adrenoleukodystrophy10.1
42succinic semialdehyde dehydrogenase deficiency10.1
43neuronitis10.1
44appendicitis10.1
45progressive supranuclear palsy10.1
46viral encephalitis10.1
47tongue cancer10.1
48adult syndrome10.1
49cerebral malaria10.1
50bipolar i disorder10.1

Graphical network of the top 20 diseases related to Neuroleptic Malignant Syndrome:



Diseases related to neuroleptic malignant syndrome

Clinical Features for Neuroleptic Malignant Syndrome

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Drugs & Therapeutics for Neuroleptic Malignant Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Neuroleptic Malignant Syndrome

Drug clinical trials:

Search ClinicalTrials for Neuroleptic Malignant Syndrome

Search NIH Clinical Center for Neuroleptic Malignant Syndrome

Search CenterWatch for Neuroleptic Malignant Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Neuroleptic Malignant Syndrome

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Anatomical Context for Neuroleptic Malignant Syndrome

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32MalaCards
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MalaCards organs/tissues related to Neuroleptic Malignant Syndrome:

32
Brain, Liver, Subthalamic nucleus, Tongue

Animal Models for Neuroleptic Malignant Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuroleptic Malignant Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.7NHLRC1, MB, HTR3A, HTR2A, NPPB, DRD2
2MP:00053867.4HTR1A, HTR3A, HTR2A, DRD2, CHKB, POMC
3MP:00053766.8PIK3C2A, DRD2, HTR3A, HTR1A, CHKA, CHKB

Publications for Neuroleptic Malignant Syndrome

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50PubMed
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Articles related to Neuroleptic Malignant Syndrome:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Postoperative neuroleptic malignant syndrome-like symptoms improved with intravenous diazepam: a case report. (23553148)
2013
2
Comment: Neuroleptic malignant syndrome versus serotonin syndrome: the search for a diagnostic tool. (22414792)
2012
3
Ecstacy-induced delayed rhabdomyolysis and neuroleptic malignant syndrome in a patient with a novel variant in the ryanodine receptor type 1 gene. (22734812)
2012
4
Anesthetic management of a pediatric patient with neuroleptic malignant syndrome. (22101771)
2012
5
Neuroleptic malignant syndrome associated with bromocriptine withdrawal in Parkinson's disease--a case report. (21601731)
2011
6
Neuroleptic malignant syndrome associated with the use of prochlorperazine in a patient with a recent history of antipsychotic-induced neuroleptic malignant syndrome. (21972252)
2011
7
Neuroleptic malignant syndrome-like reaction precipitated by antipsychotics in a patient with gamma-butyrolactone withdrawal. (21817917)
2011
8
A case study: neuroleptic malignant syndrome with risperidone and CYP2D6 gene variation. (21749835)
2011
9
Are neuroleptic malignant syndrome and serotonin syndrome the same syndrome? (21418073)
2011
10
Neuroleptic malignant syndrome with the addition of aripiprazole to clozapine. (20080143)
2010
11
Recognizing neuroleptic malignant syndrome in the emergency department: a case study. (20377802)
2010
12
Neuroleptic malignant syndrome with use of quetiapine in mental retardation. (19335404)
2009
13
Neuroleptic malignant syndrome versus malignant disease: idiosyncratic or synchronous? (19577697)
2009
14
Catatonia and mild neuroleptic malignant syndrome after initiation of long-acting injectable risperidone: case report. (18794658)
2008
15
Psychosis or atypical neuroleptic malignant syndrome in an adolescent? (18928418)
2008
16
A Case of neuroleptic malignant syndrome accompanied to an atypical antipsychotic agent: risperidone. (18539333)
2008
17
Neuroleptic malignant syndrome in elderly patients. (17425496)
2007
18
Catatonic variants, hyperthermic extrapyramidal reactions, and subtypes of neuroleptic malignant syndrome. (17453656)
2007
19
Neuroleptic malignant syndrome is malignant catatonia, warranting treatments efficacious for catatonia. (16675086)
2006
20
Neuroleptic malignant syndrome: need for early diagnosis and therapy. (16773963)
2006
21
Methylphenidate-induced neuroleptic malignant syndrome: a case report. (16862256)
2006
22
Brain injury following neuroleptic malignant syndrome: case report and review of the literature. (16809210)
2006
23
Possible neuroleptic malignant syndrome related to concomitant treatment with paroxetine and alprazolam. (16720068)
2006
24
Neuroleptic malignant syndrome: diagnostic and therapeutic dilemmas. (16082075)
2005
25
Extrapontine myelinolysis resembling neuroleptic malignant syndrome. (16282856)
2005
26
Neuroleptic malignant syndrome and atypical antipsychotic drugs. (15119907)
2004
27
Neuroleptic malignant syndrome induced by donepezil. (14731314)
2004
28
Neuroleptic malignant syndrome after haloperidol and fentanyl infusion in a patient with cancer with severe mineral imbalance. (15684854)
2004
29
Neuroleptic malignant syndrome with severe liver failure. (12904200)
2003
30
Neuroleptic malignant syndrome after addition of paroxetine to olanzapine. (14624202)
2003
31
Acute cardiac failure in neuroleptic malignant syndrome. (12921821)
2003
32
Neuroleptic Malignant Syndrome with ziprasidone. (12454565)
2002
33
Neuroleptic malignant syndrome following BMT. (12040481)
2002
34
Neuroleptic malignant syndrome associated with quetiapine. (11086565)
2000
35
Neuroleptic malignant syndrome due to citalopram overdose. (11190373)
2000
36
Neuroleptic malignant syndrome after antipsychotic drug administration during benzodiazepine withdrawal. (10770479)
2000
37
Neuroleptic malignant syndrome during olanzapine and levomepromazine treatment. (11008860)
2000
38
Muscle changes in the neuroleptic malignant syndrome. (10823143)
2000
39
Electroconvulsive therapy for the treatment of neuroleptic malignant syndrome with psychotic symptoms: a report of five cases. (10378156)
1999
40
Neuroleptic malignant syndrome due to promethazine. (10548178)
1999
41
Olanzapine-induced neuroleptic malignant syndrome with mental retardation. (10401467)
1999
42
Sympathoadrenal hyperactivity and the etiology of neuroleptic malignant syndrome. (9989551)
1999
43
Carbamazepine in the treatment of neuroleptic malignant syndrome. (10023520)
1999
44
Neuroleptic malignant syndrome with risperidone. (9165568)
1997
45
Cerebellar degeneration following neuroleptic malignant syndrome. (9519191)
1997
46
Neuroleptic malignant syndrome and hydroxylase gene mutations: no association with CYP2D6A or CYP2D6B. (9323326)
1997
47
Neuroleptic malignant syndrome following a lithium-induced nephrogenic diabetes insipidus. (19698475)
1996
48
No association between the neuroleptic malignant syndrome and mutations in the RYR1 gene associated malignant hyperthermia. (8981316)
1996
49
An atypical course of neuroleptic malignant syndrome. (8006200)
1994
50
Neurogenic bladder in neuroleptic malignant syndrome. (2038788)
1991

Genetic Variations for Neuroleptic Malignant Syndrome

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Expression for genes affiliated with Neuroleptic Malignant Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroleptic Malignant Syndrome

Search GEO for disease gene expression data for Neuroleptic Malignant Syndrome.

Pathways for genes affiliated with Neuroleptic Malignant Syndrome

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Neuroleptic Malignant Syndrome

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Sources:
11DrugBank, 44Novoseek, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 297)
idCompoundScoreTop Affiliating Genes
1Pipotiazine119.9DRD2, CYP2D6, HTR2A, HTR1A
2amperozide449.8HTR1A, DRD2, HTR2A, HTR3A
3mcpp449.8HTR3A, CYP2D6, HTR1A, HTR2A
4piperazine44 1110.8HTR2A, CYP2D6, DRD2, HTR1A
5granisetron44 1110.8DRD2, HTR3A, CYP2D6, HTR2A
6pindolol44 28 1111.8HTR3A, HTR2A, CYP2D6, HTR1A
7sertindole28 44 1111.7CYP2D6, HTR2A, HTR1A, DRD2
8trimipramine49 44 1111.7CYP2D6, DRD2, HTR2A, HTR1A
9ritanserin28 4410.7HTR3A, HTR1A, DRD2, HTR2A
10spiperone28 4410.7HTR3A, HTR2A, DRD2, HTR1A
11ipsapirone44 2810.7HTR1A, POMC, HTR2A, HTR3A
12buspirone44 28 1111.6HTR3A, DRD2, CYP2D6, HTR1A, HTR2A
13ropinirole44 1110.6HTR1A, CYP2D6, DRD2, HTR2A
14nefazodone44 49 1111.6HTR2A, CYP2D6, HTR1A, HTR3A
15iloperidone49 44 28 1112.6HTR1A, HTR3A, DRD2, HTR2A, CYP2D6
16aripiprazole28 49 44 11 2413.6DRD2, CYP2D6, HTR2A, HTR1A, HTR3A
17pimozide28 49 44 1112.6HTR2A, HTR1A, DRD2, CYP2D6
18ziprasidone49 28 44 1112.6HTR3A, HTR1A, CYP2D6, DRD2, HTR2A
19yohimbine44 28 2 1112.6HTR3A, DRD2, CYP2D6, HTR2A, HTR1A
20quetiapine44 49 28 11 2413.6DRD2, CYP2D6, HTR2A, HTR1A, HTR3A
21fenfluramine28 44 1111.5HTR3A, HTR1A, CYP2D6, POMC, HTR2A
22fluoxetine49 44 28 1112.5HTR3A, HTR2A, DRD2, CYP2D6, HTR1A
23lisuride28 44 1111.5HTR1A, HTR2A, DRD2, CYP2D6
24alpha-hydroxybutyrate449.5PIK3C2A, GPT, CHKB, MB
25succinylcholine44 28 1111.5RYR1, CHKB, MB, PIK3C2A
26chlorpromazine44 28 49 1112.4HTR1A, CYP2D6, DRD2, HTR2A, CHKB, HTR3A
27maoa449.4HTR2A, DRD2, POMC, HTR1A
28mirtazapine49 44 1111.3HTR3A, HTR2A, POMC, CYP2D6
29olanzapine49 44 28 11 2413.2CHKB, DRD2, HTR1A, CYP2D6, ANKK1, HTR2A
30halothane44 28 1111.2CHKB, RYR1, PIK3C2A, MB, CYP2D6
31thioridazine28 44 49 1112.2HTR2A, CYP2D6, HTR1A, DRD2
32dantrolene44 28 1111.1CHKB, PIK3C2A, MB, RYR1, RYR3
33bromocriptine28 44 1111.1DRD2, PIK3C2A, HTR1A, HTR2A, POMC
345-hydroxytryptamine449.1POMC, F2RL1, DRD2, HTR2A, HTR3A, HTR1A
35fluvastatin44 49 28 1112.0CYP2D6, GPT, CHKB, MB, PIK3C2A
36risperidone28 44 49 59 11 2413.8HTR1A, HTR3A, HTR2A, DRD2, CHKB, ANKK1
37cocaine44 119.7POMC, GPT, CYP2D6, MB, DRD2, PIK3C2A
38prednisolone44 28 1110.7MB, NPPB, PIK3C2A, CHKB, POMC, GPT
39clozapine44 28 49 1111.3HTR1A, HTR3A, HTR2A, DRD2, CHKB, ANKK1
40pravastatin44 49 28 11 2412.2CYP2D6, CHKB, CHKA, PIK3C2A, GPT, NPPB
41dopamine44 28 11 2411.2F2RL1, NPPB, CYP2D6, POMC, CHKB, DRD2
42atorvastatin44 49 28 11 2412.2CYP2D6, NPPB, PIK3C2A, CHKA, CHKB, GPT
43citrate448.0CPT2, POMC, CHKB, CHKA, PIK3C2A, MB
44thyroxine44 248.9MB, CHKA, GPT, PIK3C2A, POMC, CHKB
45haloperidol44 28 2 49 1111.7CYP2D6, POMC, DRD2, NPPB, HTR2A, HTR3A
46adenylate447.7CHKA, CPT2, MB, HTR1A, POMC, GPT
47norepinephrine44 11 249.5MB, HTR3A, HTR2A, DRD2, PIK3C2A, CHKB
48creatinine447.1PIK3C2A, CPT2, NPPB, MB, CHKA, CHKB
49acetylcholine44 49 28 11 2411.0RYR1, F2RL1, CYP2D6, POMC, MB, HTR1A
50glutamate446.8CHKA, CPT2, F2RL1, GPT, RYR1, CHKB

GO Terms for genes affiliated with Neuroleptic Malignant Syndrome

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16Gene Ontology
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Cellular components related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1junctional membrane complexGO:0303149.7RYR3, RYR1

Biological processes related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.2HTR1A, HTR2A
2negative regulation of synaptic transmission, glutamatergicGO:05196710.1DRD2, HTR2A
3regulation of dopamine secretionGO:01405910.0DRD2, HTR2A
4regulation of behaviorGO:05079510.0HTR2A, HTR1A
5cellular response to caffeineGO:0713139.9RYR3, RYR1
6serotonin receptor signaling pathwayGO:0072109.9HTR2A, HTR3A, HTR1A
7release of sequestered calcium ion into cytosolGO:0512099.9RYR1, DRD2, HTR2A
8positive regulation of urine volumeGO:0358109.8DRD2, NPPB
9positive regulation of renal sodium excretionGO:0358159.8DRD2, NPPB
10CDP-choline pathwayGO:0066579.7CHKB, CHKA
11cellular calcium ion homeostasisGO:0068749.6HTR2A, DRD2, RYR3
12positive regulation of ERK1 and ERK2 cascadeGO:0703749.5HTR2A, DRD2, F2RL1
13phosphatidylethanolamine biosynthetic processGO:0066469.2CHKB, CHKA

Molecular functions related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1G-protein alpha-subunit bindingGO:0019659.9F2RL1, HTR2A
2serotonin receptor activityGO:0049939.8HTR1A, HTR3A, HTR2A
3ryanodine-sensitive calcium-release channel activityGO:0052199.7RYR3, RYR1
4calcium-release channel activityGO:0152789.6RYR3, RYR1
5choline kinase activityGO:0041039.6CHKB, CHKA
6serotonin bindingGO:0513789.5HTR2A, HTR3A
7ethanolamine kinase activityGO:0043059.5CHKA, CHKB
8drug bindingGO:0081449.1CYP2D6, CHKA, DRD2, HTR2A

Products for genes affiliated with Neuroleptic Malignant Syndrome

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  • Antibodies
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Sources for Neuroleptic Malignant Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet