MCID: NRL004
MIFTS: 58

Neuroleptic Malignant Syndrome malady

Neuronal diseases category

Summaries for Neuroleptic Malignant Syndrome

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Neuroleptic malignant syndrome is a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Symptoms include high fever, sweating, unstable blood pressure, stupor, muscular rigidity, and autonomic dysfunction. In most cases, the disorder develops within the first 2 weeks of treatment with the drug; however, the disorder may develop any time during the therapy period. The syndrome can also occur in people taking anti-Parkinsonism drugs known as dopaminergics if those drugs are discontinued abruptly.

MalaCards: Neuroleptic Malignant Syndrome is related to malignant hyperthermia and parkinson's disease. An important gene associated with Neuroleptic Malignant Syndrome is NHLRC1 (NHL repeat containing 1), and among its related pathways are Codeine and morphine metabolism and Monoamine GPCRs. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds Pipotiazine and amperozide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and subthalamic nucleus, and related mouse phenotypes are muscle and behavior/neurological.

Wikipedia:63 Neuroleptic malignant syndrome (NMS) is a life-threatening neurological disorder most often caused by an... more...

Aliases & Classifications for Neuroleptic Malignant Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
neuroleptic malignant syndrome:
Prevalence: 1-5/10000


Aliases & Descriptions:

neuroleptic malignant syndrome 8 42 43 10 44 48 60


External Ids:

Disease Ontology8 DOID:14464
ICD9CM27 333.92
MeSH34 D009459
MESH via Orphanet35 D009459
ICD10 via Orphanet26 G21.0
SNOMED-CT via Orphanet57 15244003
UMLS via Orphanet61 C0027849

Related Diseases for Neuroleptic Malignant Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Neuroleptic Malignant Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1malignant hyperthermia30.8MB, PIK3C2A, RYR1, RYR3
2parkinson's disease30.8HTR1A, HTR3A, HTR2A, DRD2, CHKB, CYP2D6
3dementia30.5HTR1A, HTR3A, HTR2A, PIK3C2A, CYP2D6, NHLRC1
4schizophrenia30.5MB, HTR1A, HTR3A, HTR2A, DRD2, CHKB
5bipolar disorder30.5HTR1A, HTR3A, HTR2A, DRD2
6malignant hyperthermia susceptibility30.3RYR1
7cocaine abuse30.3HTR3A, DRD2
8myocardial infarction30.3MB, HTR3A, HTR2A, NPPB, PIK3C2A, CHKA
9anxiety disorder30.1HTR3A
10hyperglycemia30.1POMC
11diarrhea30.1HTR3A
12disseminated intravascular coagulation30.1MB, PIK3C2A
13neuropathy30.1RYR1, PIK3C2A, MB
14amnestic disorder30.1HTR1A, HTR3A
15generalized anxiety disorder30.1HTR1A, HTR3A, HTR2A
16epilepsy syndrome30.1NHLRC1, CYP2D6, HTR3A, HTR1A
17pneumonia30.1PIK3C2A, MB
18brain disease30.1RYR1, GPT, CPT2
19acute myocardial infarction30.1MB, HTR3A, HTR2A, NPPB, PIK3C2A, CHKA
20cerebritis10.5
21lewy body dementia10.3
22cerebral palsy10.3
23burns10.2
24status epilepticus10.2
25diabetic ketoacidosis10.2
26systemic lupus erythematosus10.2
27striatonigral degeneration10.2
28typhoid fever10.2
29encephalitis10.2
30lupus erythematosus10.2
31syndromic diarrhea10.1
32axonal neuropathy10.1
33paranoid schizophrenia10.1
34pulmonary edema10.1
35huntington's disease10.1
36hypophosphatemia10.1
37stevens-johnson syndrome10.1
38neurogenic bladder10.1
39toxic encephalopathy10.1
40diabetes insipidus10.1
41adrenoleukodystrophy10.1
42succinic semialdehyde dehydrogenase deficiency10.1
43neuronitis10.1
44appendicitis10.1
45progressive supranuclear palsy10.1
46viral encephalitis10.1
47tongue cancer10.1
48adult syndrome10.1
49cerebral malaria10.1
50bipolar i disorder10.1

Graphical network of the top 20 diseases related to Neuroleptic Malignant Syndrome:



Diseases related to neuroleptic malignant syndrome

Clinical Features for Neuroleptic Malignant Syndrome

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Drugs & Therapeutics for Neuroleptic Malignant Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Neuroleptic Malignant Syndrome

Drug clinical trials:

Search ClinicalTrials for Neuroleptic Malignant Syndrome

Search NIH Clinical Center for Neuroleptic Malignant Syndrome

Search CenterWatch for Neuroleptic Malignant Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Neuroleptic Malignant Syndrome

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Anatomical Context for Neuroleptic Malignant Syndrome

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32MalaCards
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MalaCards organs/tissues related to Neuroleptic Malignant Syndrome:

32
Brain, Liver, Subthalamic nucleus, Tongue

Animal Models for Neuroleptic Malignant Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuroleptic Malignant Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.7NHLRC1, MB, HTR3A, HTR2A, NPPB, DRD2
2MP:00053867.4HTR1A, HTR3A, HTR2A, DRD2, CHKB, POMC
3MP:00053766.8PIK3C2A, DRD2, HTR3A, HTR1A, CHKA, CHKB

Publications for Neuroleptic Malignant Syndrome

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50PubMed
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Articles related to Neuroleptic Malignant Syndrome:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
The great masquerader: atypical neuroleptic malignant syndrome after cardiac surgery. (22939971)
2014
2
Two unusual complications of neuroleptic malignant syndrome. (23983420)
2013
3
Catatonia, neuroleptic malignant syndrome, and cotard syndrome in a 22-year-old woman: a case report. (24093068)
2013
4
Neuroleptic malignant syndrome-induced massive coagulopathy treated by recombinant human soluble thrombomodulin. (23218866)
2013
5
Neuroleptic malignant syndrome in a patient with tongue cancer: a report of a rare case. (23853728)
2013
6
Ascertaining instances of neuroleptic malignant syndrome in a secondary mental healthcare electronic medical records database: the SLAM BRC Case Register. (23983959)
2012
7
Antipsychotic dose escalation as a trigger for neuroleptic malignant syndrome (NMS): literature review and case series report. (23194104)
2012
8
Propofol-remifentanil combination for management of electroconvulsive therapy in a patient with neuroleptic malignant syndrome. (22548079)
2012
9
Forme fruste of neuroleptic malignant syndrome associated with the use of sertraline. (21147016)
2011
10
Possible contribution of XYY syndrome to neuroleptic malignant syndrome in a child receiving quetiapine. (20208052)
2010
11
Neuroleptic malignant syndrome with aripiprazole in Huntington's disease. (20669301)
2010
12
Bilateral chronic subdural haematoma misdiagnosed as neuroleptic malignant syndrome. (20304898)
2010
13
The nature of hyperthermia in neuroleptic malignant syndrome and the use of bromocriptine. (20361363)
2010
14
Possible neuroleptic malignant syndrome during paliperidone administration: a case report. (20075663)
2010
15
Resolution of symptoms in neuroleptic malignant syndrome. (21180414)
2010
16
Olanzapine-induced neuroleptic malignant syndrome in a patient with paranoid schizophrenia. (19067992)
2009
17
A case of neuroleptic malignant syndrome induced by risperidone in a schizophrenic woman. (19442104)
2009
18
Extreme elevation of creatinine phosphokinase levels in neuroleptic malignant syndrome associated with atypical antipsychotics. (19122020)
2009
19
Infections as complications of neuroleptic malignant syndrome. (18609425)
2009
20
Genetic analysis of ryanodine receptor 1 gene and carnitine palmitoyltransferase II gene: an autopsy case of neuroleptic malignant syndrome related to vegetamin. (19269221)
2009
21
Catatonia and neuroleptic malignant syndrome. (19034757)
2008
22
Atypical neuroleptic malignant syndrome in an adolescent. (18439120)
2008
23
Neuroleptic malignant syndrome and the acute phase response. (18626278)
2008
24
Neuroleptic malignant syndrome. Diagnostic and therapeutic dilemmas in a general hospital setting. (21063378)
2008
25
Aripiprazole as the causative agent of neuroleptic malignant syndrome: a case report. (17607339)
2007
26
"Atypical" neuroleptic malignant syndrome and the spectrum of malignant cerebrotoxic syndromes. (17687712)
2007
27
Intestinal pseudo-obstruction and neuroleptic malignant syndrome in a chronically constipated parkinsonian patient. (16618352)
2006
28
Olanzapine-associated neuroleptic malignant syndrome. (16863495)
2006
29
Neuroleptic malignant syndrome and serotonin syndrome in the critical care setting: case analysis. (16923659)
2006
30
Psychotropic discontinuation symptoms: a case of withdrawal neuroleptic malignant syndrome. (17088172)
2006
31
Neuropsychiatric sequelae of neuroleptic malignant syndrome. (16062103)
2005
32
Atypical case of neuroleptic malignant syndrome caused by olanzapine and carbamazepine. (21120111)
2005
33
Neuroleptic malignant syndrome with promethazine. (15660719)
2005
34
Reversible cardiomyopathy as the autonomic involvement of neuroleptic malignant syndrome. (15645651)
2004
35
Neuroleptic Malignant Syndrome: A Primary Care Perspective. (15514687)
2004
36
Atypical (olanzapine) plus conventional (fluphenazine) neuroleptic treatment associated with the neuroleptic malignant syndrome. (14624203)
2003
37
Difficulties in diagnosing neuroleptic malignant syndrome. (23978926)
2002
38
Atypical neuroleptic malignant syndrome associated with olanzapine. (12013364)
2002
39
Three patients with isolated adrenocorticotropin deficiency presenting with neuroleptic malignant syndrome-like symptoms. (11446676)
2001
40
Neuroleptic malignant syndrome associated with long-term clozapine treatment: report of a case and results of a clozapine rechallenge. (11601195)
2001
41
Neuroleptic malignant syndrome following withdrawal of amantadine in a patient with influenza A encephalopathy. (11421428)
2001
42
Is Lorazepam a treatment for neuroleptic malignant syndrome? (18197156)
2000
43
Risperidone-induced neuroleptic malignant syndrome : a case report. (21407918)
2000
44
"Multiple ECT" for neuroleptic malignant syndrome. (10614039)
1999
45
Recurrence of neuroleptic malignant syndrome with olanzapine treatment. (10553758)
1999
46
Droperidol-induced neuroleptic malignant syndrome. (10492720)
1999
47
Neuroleptic malignant syndrome associated with diphenhydramine and diprophyllin overdose in a depressed patient. (10064181)
1999
48
Electroconvulsive treatment of neuroleptic malignant syndrome: a review and report of cases. (10544988)
1999
49
Ecstasy intoxication: an overlap between serotonin syndrome and neuroleptic malignant syndrome. (8777769)
1996
50
Malignant hyperthermia susceptibility in neuroleptic malignant syndrome. (3605730)
1987

Genetic Variations for Neuroleptic Malignant Syndrome

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Expression for genes affiliated with Neuroleptic Malignant Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroleptic Malignant Syndrome

Search GEO for disease gene expression data for Neuroleptic Malignant Syndrome.

Pathways for genes affiliated with Neuroleptic Malignant Syndrome

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Neuroleptic Malignant Syndrome

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Sources:
11DrugBank, 44Novoseek, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 297)
idCompoundScoreTop Affiliating Genes
1Pipotiazine119.9DRD2, HTR2A, CYP2D6, HTR1A
2amperozide449.8HTR3A, HTR2A, DRD2, HTR1A
3mcpp449.8HTR3A, HTR2A, HTR1A, CYP2D6
4piperazine44 1110.8CYP2D6, DRD2, HTR2A, HTR1A
5granisetron44 1110.8HTR3A, DRD2, CYP2D6, HTR2A
6pindolol44 28 1111.8HTR2A, HTR1A, HTR3A, CYP2D6
7trimipramine49 44 1111.7HTR2A, HTR1A, CYP2D6, DRD2
8ritanserin28 4410.7HTR3A, DRD2, HTR1A, HTR2A
9spiperone28 4410.7DRD2, HTR2A, HTR3A, HTR1A
10sertindole28 44 1111.7CYP2D6, DRD2, HTR2A, HTR1A
11ipsapirone44 2810.7POMC, HTR1A, HTR3A, HTR2A
12nefazodone44 49 1111.7HTR1A, CYP2D6, HTR2A, HTR3A
13buspirone44 28 1111.6CYP2D6, HTR2A, HTR3A, HTR1A, DRD2
14iloperidone49 44 28 1112.6DRD2, HTR2A, CYP2D6, HTR3A, HTR1A
15aripiprazole28 49 44 11 2413.6HTR1A, HTR3A, HTR2A, DRD2, CYP2D6
16ziprasidone49 28 44 1112.6HTR1A, CYP2D6, DRD2, HTR2A, HTR3A
17yohimbine44 28 2 1112.6DRD2, HTR3A, HTR1A, CYP2D6, HTR2A
18quetiapine44 49 28 11 2413.6HTR2A, HTR3A, CYP2D6, DRD2, HTR1A
19ropinirole44 1110.6CYP2D6, DRD2, HTR2A, HTR1A
20fenfluramine28 44 1111.5POMC, CYP2D6, HTR1A, HTR3A, HTR2A
21fluoxetine49 44 28 1112.5HTR1A, CYP2D6, HTR3A, HTR2A, DRD2
22maoa449.5HTR2A, HTR1A, POMC, DRD2
23pimozide28 49 44 1112.5HTR1A, HTR2A, DRD2, CYP2D6
24thioridazine28 44 49 1112.5HTR2A, CYP2D6, HTR1A, DRD2
25alpha-hydroxybutyrate449.5CHKB, GPT, PIK3C2A, MB
26succinylcholine44 28 1111.5MB, CHKB, RYR1, PIK3C2A
27chlorpromazine44 28 49 1112.4HTR1A, HTR3A, HTR2A, DRD2, CHKB, CYP2D6
28mirtazapine49 44 1111.4CYP2D6, POMC, HTR2A, HTR3A
29olanzapine49 44 28 11 2413.2HTR1A, CHKB, DRD2, HTR2A, HTR3A, ANKK1
30halothane44 28 1111.2RYR1, CYP2D6, CHKB, MB, PIK3C2A
31mianserin28 44 1111.1HTR1A, HTR3A, HTR2A, CYP2D6
32dantrolene44 28 1111.1RYR3, RYR1, PIK3C2A, MB, CHKB
33bromocriptine28 44 1111.1HTR1A, PIK3C2A, DRD2, HTR2A, POMC
345-hydroxytryptamine449.1F2RL1, HTR1A, HTR3A, HTR2A, DRD2, POMC
35fluvastatin44 49 28 1112.0GPT, CYP2D6, CHKB, PIK3C2A, MB
36risperidone28 44 49 59 11 2413.9HTR1A, HTR3A, HTR2A, DRD2, CHKB, ANKK1
37cocaine44 119.7MB, DRD2, PIK3C2A, CHKB, POMC, CYP2D6
38prednisolone44 28 1110.7GPT, POMC, CHKB, NPPB, PIK3C2A, MB
39clozapine44 28 49 1111.3HTR1A, HTR3A, HTR2A, DRD2, CHKB, ANKK1
40pravastatin44 49 28 11 2412.2CHKA, GPT, NPPB, PIK3C2A, CHKB, CYP2D6
41dopamine44 28 11 2411.2HTR2A, DRD2, CHKB, POMC, CYP2D6, NPPB
42atorvastatin44 49 28 11 2412.2GPT, NPPB, PIK3C2A, CHKA, CHKB, CYP2D6
43citrate448.0CHKB, POMC, CPT2, MB, PIK3C2A, CHKA
44thyroxine44 248.9PIK3C2A, CHKA, CHKB, NPPB, GPT, POMC
45haloperidol44 28 2 49 1111.7HTR1A, MB, HTR3A, HTR2A, GPT, CYP2D6
46adenylate447.7HTR3A, CHKA, MB, DRD2, GPT, HTR1A
47norepinephrine44 11 249.5POMC, CHKB, PIK3C2A, DRD2, NPPB, HTR2A
48creatinine447.1CHKA, GPT, MB, NPPB, RYR1, POMC
49acetylcholine44 49 28 11 2411.0F2RL1, RYR1, CYP2D6, POMC, CHKA, PIK3C2A
50glutamate446.8F2RL1, GPT, RYR1, CPT2, MB, DRD2

GO Terms for genes affiliated with Neuroleptic Malignant Syndrome

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16Gene Ontology
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Cellular components related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1junctional membrane complexGO:0303149.7RYR3, RYR1

Biological processes related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.2HTR1A, HTR2A
2negative regulation of synaptic transmission, glutamatergicGO:05196710.1DRD2, HTR2A
3regulation of dopamine secretionGO:01405910.0DRD2, HTR2A
4regulation of behaviorGO:05079510.0HTR2A, HTR1A
5cellular response to caffeineGO:0713139.9RYR3, RYR1
6serotonin receptor signaling pathwayGO:0072109.9HTR2A, HTR3A, HTR1A
7release of sequestered calcium ion into cytosolGO:0512099.9RYR1, DRD2, HTR2A
8positive regulation of urine volumeGO:0358109.8DRD2, NPPB
9positive regulation of renal sodium excretionGO:0358159.8DRD2, NPPB
10CDP-choline pathwayGO:0066579.7CHKB, CHKA
11cellular calcium ion homeostasisGO:0068749.6HTR2A, DRD2, RYR3
12positive regulation of ERK1 and ERK2 cascadeGO:0703749.5HTR2A, DRD2, F2RL1
13phosphatidylethanolamine biosynthetic processGO:0066469.2CHKB, CHKA

Molecular functions related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1G-protein alpha-subunit bindingGO:0019659.9F2RL1, HTR2A
2serotonin receptor activityGO:0049939.8HTR1A, HTR3A, HTR2A
3ryanodine-sensitive calcium-release channel activityGO:0052199.7RYR3, RYR1
4calcium-release channel activityGO:0152789.6RYR3, RYR1
5choline kinase activityGO:0041039.6CHKB, CHKA
6serotonin bindingGO:0513789.5HTR2A, HTR3A
7ethanolamine kinase activityGO:0043059.5CHKA, CHKB
8drug bindingGO:0081449.1CYP2D6, CHKA, DRD2, HTR2A

Products for genes affiliated with Neuroleptic Malignant Syndrome

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Sources for Neuroleptic Malignant Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet