MCID: NRL004
MIFTS: 58

Neuroleptic Malignant Syndrome malady

Neuronal diseases category

Summaries for Neuroleptic Malignant Syndrome

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Neuroleptic malignant syndrome is a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Symptoms include high fever, sweating, unstable blood pressure, stupor, muscular rigidity, and autonomic dysfunction. In most cases, the disorder develops within the first 2 weeks of treatment with the drug; however, the disorder may develop any time during the therapy period. The syndrome can also occur in people taking anti-Parkinsonism drugs known as dopaminergics if those drugs are discontinued abruptly.

MalaCards: Neuroleptic Malignant Syndrome is related to malignant hyperthermia and parkinson's disease. An important gene associated with Neuroleptic Malignant Syndrome is NHLRC1 (NHL repeat containing 1), and among its related pathways are Codeine and morphine metabolism and Monoamine GPCRs. The drugs bromocriptine and 2-bromoergocryptine mesylate and the compounds Pipotiazine and amperozide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and subthalamic nucleus, and related mouse phenotypes are muscle and behavior/neurological.

Wikipedia:63 Neuroleptic malignant syndrome (NMS) is a life-threatening neurological disorder most often caused by an... more...

Aliases & Classifications for Neuroleptic Malignant Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
neuroleptic malignant syndrome:
Prevalence: 1-5/10000


Aliases & Descriptions:

neuroleptic malignant syndrome 8 42 43 10 44 48 60


External Ids:

Disease Ontology8 DOID:14464
ICD9CM27 333.92
MeSH34 D009459
MESH via Orphanet35 D009459
ICD10 via Orphanet26 G21.0
SNOMED-CT via Orphanet57 15244003
UMLS via Orphanet61 C0027849

Related Diseases for Neuroleptic Malignant Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Neuroleptic Malignant Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1malignant hyperthermia30.8MB, PIK3C2A, RYR1, RYR3
2parkinson's disease30.8HTR1A, HTR3A, HTR2A, DRD2, CHKB, CYP2D6
3dementia30.5HTR1A, HTR3A, HTR2A, PIK3C2A, CYP2D6, NHLRC1
4schizophrenia30.5MB, HTR1A, HTR3A, HTR2A, DRD2, CHKB
5bipolar disorder30.5HTR1A, HTR3A, HTR2A, DRD2
6malignant hyperthermia susceptibility30.3RYR1
7cocaine abuse30.3HTR3A, DRD2
8myocardial infarction30.3MB, HTR3A, HTR2A, NPPB, PIK3C2A, CHKA
9anxiety disorder30.1HTR3A
10hyperglycemia30.1POMC
11diarrhea30.1HTR3A
12disseminated intravascular coagulation30.1MB, PIK3C2A
13neuropathy30.1RYR1, PIK3C2A, MB
14amnestic disorder30.1HTR1A, HTR3A
15generalized anxiety disorder30.1HTR1A, HTR3A, HTR2A
16epilepsy syndrome30.1NHLRC1, CYP2D6, HTR3A, HTR1A
17pneumonia30.1PIK3C2A, MB
18brain disease30.1RYR1, GPT, CPT2
19acute myocardial infarction30.1MB, HTR3A, HTR2A, NPPB, PIK3C2A, CHKA
20cerebritis10.5
21lewy body dementia10.3
22cerebral palsy10.3
23burns10.2
24status epilepticus10.2
25diabetic ketoacidosis10.2
26systemic lupus erythematosus10.2
27striatonigral degeneration10.2
28typhoid fever10.2
29encephalitis10.2
30lupus erythematosus10.2
31syndromic diarrhea10.1
32axonal neuropathy10.1
33paranoid schizophrenia10.1
34pulmonary edema10.1
35huntington's disease10.1
36hypophosphatemia10.1
37stevens-johnson syndrome10.1
38neurogenic bladder10.1
39toxic encephalopathy10.1
40diabetes insipidus10.1
41adrenoleukodystrophy10.1
42succinic semialdehyde dehydrogenase deficiency10.1
43neuronitis10.1
44appendicitis10.1
45progressive supranuclear palsy10.1
46viral encephalitis10.1
47tongue cancer10.1
48adult syndrome10.1
49cerebral malaria10.1
50bipolar i disorder10.1

Graphical network of the top 20 diseases related to Neuroleptic Malignant Syndrome:



Diseases related to neuroleptic malignant syndrome

Clinical Features for Neuroleptic Malignant Syndrome

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Drugs & Therapeutics for Neuroleptic Malignant Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Neuroleptic Malignant Syndrome

Drug clinical trials:

Search ClinicalTrials for Neuroleptic Malignant Syndrome

Search NIH Clinical Center for Neuroleptic Malignant Syndrome

Search CenterWatch for Neuroleptic Malignant Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Neuroleptic Malignant Syndrome

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Anatomical Context for Neuroleptic Malignant Syndrome

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32MalaCards
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MalaCards organs/tissues related to Neuroleptic Malignant Syndrome:

32
Brain, Liver, Subthalamic nucleus, Tongue

Animal Models for Neuroleptic Malignant Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuroleptic Malignant Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.7NHLRC1, MB, HTR3A, HTR2A, NPPB, DRD2
2MP:00053867.4HTR1A, HTR3A, HTR2A, DRD2, CHKB, POMC
3MP:00053766.8PIK3C2A, DRD2, HTR3A, HTR1A, CHKA, CHKB

Publications for Neuroleptic Malignant Syndrome

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50PubMed
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Articles related to Neuroleptic Malignant Syndrome:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Recurrence of neuroleptic malignant syndrome. (24096397)
2013
2
Neuroleptic malignant syndrome during multiple antipsychotic therapy. (22038421)
2013
3
Olanzapine-induced diabetic ketoacidosis and neuroleptic malignant syndrome with rhabdomyolysis: a case report. (24396655)
2013
4
Atypical neuroleptic malignant syndrome in H1N1 pneumonia. (23376873)
2013
5
Neuroleptic malignant syndrome (parkinsonism-hyperpyrexia syndrome) after deep brain stimulation of the subthalamic nucleus. (23465352)
2013
6
VGKC-complex antibody mediated encephalitis presenting with psychiatric features and neuroleptic malignant syndrome - further expanding the phenotype. (22409578)
2012
7
Lithium-induced fatal neuroleptic malignant syndrome in a patient not being concomitantly treated with commonly offending agents. (23217454)
2012
8
Neuroleptic malignant syndrome: a neuroimmunologic hypothesis. (20696799)
2010
9
Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature. (18801826)
2010
10
Neuroleptic malignant syndrome developing after acute overdose with olanzapine and chlorpromazine. (19191213)
2009
11
In response to Morris et al.'s "Neuroleptic malignant syndrome developing after acute overdose with olanzapine and chlorpromazine". (20012252)
2009
12
Atypical neuroleptic malignant syndrome with quetiapine: a case report and review of the literature. (19745653)
2009
13
Neuroleptic malignant syndrome in traumatic brain injury patients treated with haloperidol. (19276778)
2009
14
Neuroleptic malignant syndrome associated with atypical antipsychotics in pediatric patients: a review of published cases. (18572981)
2008
15
Atypical neuroleptic malignant syndrome: diagnostic controversies and considerations. (18363536)
2008
16
Neuropsychiatric systemic lupus erythematosus associated with neuroleptic malignant syndrome. (19043159)
2008
17
Endovascular cooling in a patient with neuroleptic malignant syndrome. (17706678)
2008
18
Neuroleptic malignant syndrome and serotonin syndrome. (17645916)
2007
19
Anesthetic management of electroconvulsive therapy in a patient with a known history of neuroleptic malignant syndrome. (18008129)
2007
20
Comments on the report of neuroleptic malignant syndrome induced by ziprasidone. (17455107)
2007
21
Meta-analytic evidence of systematic bias in estimates of neuroleptic malignant syndrome incidence. (17292713)
2007
22
Cerebral salt-wasting syndrome in a patient with neuroleptic malignant syndrome. (17210819)
2007
23
Epilepsy, parkinsonism, and neuroleptic malignant syndrome in a child. (17156702)
2006
24
Early bicarbonate loading and dantroline for ziprasidone/haloperidol-induced neuroleptic malignant syndrome. (16669738)
2006
25
Neuroleptic malignant syndrome in the burns patient? (16777336)
2006
26
Ziprasidone- and lithium-induced neuroleptic malignant syndrome. (16352776)
2006
27
Neuroleptic malignant syndrome related to a switch to perospirone and anticholinergic withdrawal. (16513884)
2006
28
Clomipramine induced neuroleptic malignant syndrome and pyrexia of unknown origin. (15576745)
2004
29
The evaluation and management of patients with neuroleptic malignant syndrome. (15062519)
2004
30
Clozapine-induced neuroleptic malignant syndrome and subdural hematoma. (14990770)
2004
31
Risk factors in neuroleptic malignant syndrome. A case-control study. (12558541)
2003
32
Olanzapine induced "typical" neuroleptic malignant syndrome. (12544383)
2003
33
Neuroleptic malignant syndrome in juvenile neuronal ceroid lipofuscinosis associated with low-dose risperidone therapy. (14605508)
2003
34
Neuroleptic malignant syndrome in Kufs' disease. (12588937)
2003
35
Catatonia and neuroleptic malignant syndrome: psychopathology and pathophysiology. (12486486)
2002
36
Neuroleptic malignant syndrome with prolonged catatonia in a dopa-responsive dystonia patient. (12370475)
2002
37
A case of neuroleptic malignant syndrome with quetiapine. (11884665)
2002
38
Neuroleptic malignant syndrome without neuroleptics. (11358199)
2001
39
Neuroleptic malignant syndrome precipitated by promethazine and lorazepam. (11284912)
2001
40
An autopsy case of neuroleptic malignant syndrome (NMS) and its immunohistochemical findings of muscle-associated proteins and mitochondria. (11056287)
2001
41
Residual catatonic state following neuroleptic malignant syndrome. (10770467)
2000
42
A case of neuroleptic malignant syndrome in a patient with hemodialysis. (10710250)
2000
43
Intrathecal baclofen withdrawal simulating neuroleptic malignant syndrome in a child with cerebral palsy. (10981935)
2000
44
Neuroleptic malignant syndrome after venlafaxine. (10902652)
2000
45
Sympathoadrenal hyperactivity and neuroleptic malignant syndrome. (10739453)
2000
46
Atypical neuroleptic malignant syndrome? (10500880)
1999
47
Proposed research diagnostic criteria for neuroleptic malignant syndrome. (11281981)
1999
48
Lack of association between neuroleptic malignant syndrome and polymorphisms in the 5-HT1A and 5-HT2A receptor genes. (9734554)
1998
49
Cytochrome P-450 2D6 gene polymorphism is not associated with neuroleptic malignant syndrome. (8780858)
1996
50
Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders? (8748050)
1995

Genetic Variations for Neuroleptic Malignant Syndrome

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Expression for genes affiliated with Neuroleptic Malignant Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroleptic Malignant Syndrome

Search GEO for disease gene expression data for Neuroleptic Malignant Syndrome.

Pathways for genes affiliated with Neuroleptic Malignant Syndrome

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Neuroleptic Malignant Syndrome

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Sources:
11DrugBank, 44Novoseek, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 297)
idCompoundScoreTop Affiliating Genes
1Pipotiazine119.9DRD2, CYP2D6, HTR2A, HTR1A
2amperozide449.8HTR1A, DRD2, HTR2A, HTR3A
3mcpp449.8HTR3A, CYP2D6, HTR1A, HTR2A
4piperazine44 1110.8HTR2A, CYP2D6, DRD2, HTR1A
5granisetron44 1110.8DRD2, HTR3A, CYP2D6, HTR2A
6pindolol44 28 1111.8HTR3A, HTR2A, CYP2D6, HTR1A
7sertindole28 44 1111.7CYP2D6, HTR2A, HTR1A, DRD2
8trimipramine49 44 1111.7CYP2D6, DRD2, HTR2A, HTR1A
9ritanserin28 4410.7HTR3A, HTR1A, DRD2, HTR2A
10spiperone28 4410.7HTR3A, HTR2A, DRD2, HTR1A
11ipsapirone44 2810.7HTR1A, POMC, HTR2A, HTR3A
12buspirone44 28 1111.6HTR3A, DRD2, CYP2D6, HTR1A, HTR2A
13ropinirole44 1110.6HTR1A, CYP2D6, DRD2, HTR2A
14nefazodone44 49 1111.6HTR2A, CYP2D6, HTR1A, HTR3A
15iloperidone49 44 28 1112.6HTR1A, HTR3A, DRD2, HTR2A, CYP2D6
16aripiprazole28 49 44 11 2413.6DRD2, CYP2D6, HTR2A, HTR1A, HTR3A
17pimozide28 49 44 1112.6HTR2A, HTR1A, DRD2, CYP2D6
18ziprasidone49 28 44 1112.6HTR3A, HTR1A, CYP2D6, DRD2, HTR2A
19yohimbine44 28 2 1112.6HTR3A, DRD2, CYP2D6, HTR2A, HTR1A
20quetiapine44 49 28 11 2413.6DRD2, CYP2D6, HTR2A, HTR1A, HTR3A
21fenfluramine28 44 1111.5HTR3A, HTR1A, CYP2D6, POMC, HTR2A
22fluoxetine49 44 28 1112.5HTR3A, HTR2A, DRD2, CYP2D6, HTR1A
23lisuride28 44 1111.5HTR1A, HTR2A, DRD2, CYP2D6
24alpha-hydroxybutyrate449.5PIK3C2A, GPT, CHKB, MB
25succinylcholine44 28 1111.5RYR1, CHKB, MB, PIK3C2A
26chlorpromazine44 28 49 1112.4HTR1A, CYP2D6, DRD2, HTR2A, CHKB, HTR3A
27maoa449.4HTR2A, DRD2, POMC, HTR1A
28mirtazapine49 44 1111.3HTR3A, HTR2A, POMC, CYP2D6
29olanzapine49 44 28 11 2413.2CHKB, DRD2, HTR1A, CYP2D6, ANKK1, HTR2A
30halothane44 28 1111.2CHKB, RYR1, PIK3C2A, MB, CYP2D6
31thioridazine28 44 49 1112.2HTR2A, CYP2D6, HTR1A, DRD2
32dantrolene44 28 1111.1CHKB, PIK3C2A, MB, RYR1, RYR3
33bromocriptine28 44 1111.1DRD2, PIK3C2A, HTR1A, HTR2A, POMC
345-hydroxytryptamine449.1POMC, F2RL1, DRD2, HTR2A, HTR3A, HTR1A
35fluvastatin44 49 28 1112.0CYP2D6, GPT, CHKB, MB, PIK3C2A
36risperidone28 44 49 59 11 2413.8HTR1A, HTR3A, HTR2A, DRD2, CHKB, ANKK1
37cocaine44 119.7POMC, GPT, CYP2D6, MB, DRD2, PIK3C2A
38prednisolone44 28 1110.7MB, NPPB, PIK3C2A, CHKB, POMC, GPT
39clozapine44 28 49 1111.3HTR1A, HTR3A, HTR2A, DRD2, CHKB, ANKK1
40pravastatin44 49 28 11 2412.2CYP2D6, CHKB, CHKA, PIK3C2A, GPT, NPPB
41dopamine44 28 11 2411.2F2RL1, NPPB, CYP2D6, POMC, CHKB, DRD2
42atorvastatin44 49 28 11 2412.2CYP2D6, NPPB, PIK3C2A, CHKA, CHKB, GPT
43citrate448.0CPT2, POMC, CHKB, CHKA, PIK3C2A, MB
44thyroxine44 248.9MB, CHKA, GPT, PIK3C2A, POMC, CHKB
45haloperidol44 28 2 49 1111.7CYP2D6, POMC, DRD2, NPPB, HTR2A, HTR3A
46adenylate447.7CHKA, CPT2, MB, HTR1A, POMC, GPT
47norepinephrine44 11 249.5MB, HTR3A, HTR2A, DRD2, PIK3C2A, CHKB
48creatinine447.1PIK3C2A, CPT2, NPPB, MB, CHKA, CHKB
49acetylcholine44 49 28 11 2411.0RYR1, F2RL1, CYP2D6, POMC, MB, HTR1A
50glutamate446.8CHKA, CPT2, F2RL1, GPT, RYR1, CHKB

GO Terms for genes affiliated with Neuroleptic Malignant Syndrome

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16Gene Ontology
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Cellular components related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1junctional membrane complexGO:0303149.7RYR3, RYR1

Biological processes related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.2HTR1A, HTR2A
2negative regulation of synaptic transmission, glutamatergicGO:05196710.1DRD2, HTR2A
3regulation of dopamine secretionGO:01405910.0DRD2, HTR2A
4regulation of behaviorGO:05079510.0HTR2A, HTR1A
5cellular response to caffeineGO:0713139.9RYR3, RYR1
6serotonin receptor signaling pathwayGO:0072109.9HTR2A, HTR3A, HTR1A
7release of sequestered calcium ion into cytosolGO:0512099.9RYR1, DRD2, HTR2A
8positive regulation of urine volumeGO:0358109.8DRD2, NPPB
9positive regulation of renal sodium excretionGO:0358159.8DRD2, NPPB
10CDP-choline pathwayGO:0066579.7CHKB, CHKA
11cellular calcium ion homeostasisGO:0068749.6HTR2A, DRD2, RYR3
12positive regulation of ERK1 and ERK2 cascadeGO:0703749.5HTR2A, DRD2, F2RL1
13phosphatidylethanolamine biosynthetic processGO:0066469.2CHKB, CHKA

Molecular functions related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1G-protein alpha-subunit bindingGO:0019659.9F2RL1, HTR2A
2serotonin receptor activityGO:0049939.8HTR1A, HTR3A, HTR2A
3ryanodine-sensitive calcium-release channel activityGO:0052199.7RYR3, RYR1
4calcium-release channel activityGO:0152789.6RYR3, RYR1
5choline kinase activityGO:0041039.6CHKB, CHKA
6serotonin bindingGO:0513789.5HTR2A, HTR3A
7ethanolamine kinase activityGO:0043059.5CHKA, CHKB
8drug bindingGO:0081449.1CYP2D6, CHKA, DRD2, HTR2A

Products for genes affiliated with Neuroleptic Malignant Syndrome

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  • Antibodies
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Sources for Neuroleptic Malignant Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet