MCID: NRL004
MIFTS: 53

Neuroleptic Malignant Syndrome malady

Neuronal category

Summaries for Neuroleptic Malignant Syndrome

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Neuroleptic malignant syndrome is a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Symptoms include high fever, sweating, unstable blood pressure, stupor, muscular rigidity, and autonomic dysfunction. In most cases, the disorder develops within the first 2 weeks of treatment with the drug; however, the disorder may develop any time during the therapy period. The syndrome can also occur in people taking anti-Parkinsonism drugs known as dopaminergics if those drugs are discontinued abruptly.

MalaCards: Neuroleptic Malignant Syndrome is related to serotonin syndrome and malignant hyperthermia. An important gene associated with Neuroleptic Malignant Syndrome is NHLRC1 (NHL repeat containing 1), and among its related pathways are Codeine and morphine metabolism and Monoamine GPCRs. The drugs bromocriptine and dantrolene and the compounds Pipotiazine and amperozide have been mentioned in the context of this disorder. Affiliated tissues include liver, tongue and brain, and related mouse phenotypes are muscle and behavior/neurological.

Wikipedia:64 Neuroleptic malignant syndrome (NMS) is a life-threatening neurological disorder most often caused by an... more...

Aliases & Classifications for Neuroleptic Malignant Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
neuroleptic malignant syndrome:
Prevalence: 1-5/10000


Aliases & Descriptions:

neuroleptic malignant syndrome 8 43 44 10 45 49 61


External Ids:

Disease Ontology8 DOID:14464
ICD9CM27 333.92
MeSH35 D009459
MESH via Orphanet36 D009459
ICD10 via Orphanet26 G21.0
SNOMED-CT via Orphanet58 15244003
UMLS via Orphanet62 C0027849

Related Diseases for Neuroleptic Malignant Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Neuroleptic Malignant Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1serotonin syndrome31.1HTR1A, HTR3A, HTR2A
2malignant hyperthermia30.8PIK3C2A, RYR3, RYR1, MB
3parkinson's disease30.8CHKB, HTR1A, HTR3A, HTR2A, DRD2, CYP2D6
4bipolar disorder30.5HTR2A, HTR3A, HTR1A, DRD2
5malignant hyperthermia susceptibility30.4RYR1
6cocaine abuse30.4DRD2, HTR3A
7anxiety disorder30.1HTR3A
8amnestic disorder30.1HTR1A, HTR3A
9generalized anxiety disorder30.1HTR1A, HTR3A, HTR2A
10brain disease30.1GPT, CPT2, RYR1
11acute myocardial infarction30.1CHKB, NPPB, PIK3C2A, CHKA, HTR3A, MB
12n syndrome11.5
13brain injury10.4
14bod syndrome10.4
15cerebellar degeneration10.4
16mass syndrome10.4
17traumatic brain injury10.4
18status epilepticus10.3
19diabetic ketoacidosis10.3
20systemic lupus erythematosus10.3
21striatonigral degeneration10.3
22typhoid fever10.3
23mental retardation10.3
24burns10.1
25axonal neuropathy10.1
26paranoid schizophrenia10.1
27pulmonary edema10.1
28huntington's disease10.1
29hypophosphatemia10.1
30ladd syndrome10.1
31neurogenic bladder10.1
32west syndrome10.1
33toxic encephalopathy10.1
34diabetes insipidus10.1
35adrenoleukodystrophy10.1
36succinic semialdehyde dehydrogenase deficiency10.1
37appendicitis10.1
38progressive supranuclear palsy10.1
39viral encephalitis10.1
40tongue cancer10.1
41adult syndrome10.1
42cerebral malaria10.1
43bipolar i disorder10.1
44joubert syndrome10.1
45nephrogenic diabetes insipidus10.1
46basal ganglia disease10.1
47thrombocytopenia10.1
48char syndrome10.1
49freeman sheldon syndrome10.1
50brown syndrome10.1

Graphical network of the top 20 diseases related to Neuroleptic Malignant Syndrome:



Diseases related to neuroleptic malignant syndrome

Clinical Features for Neuroleptic Malignant Syndrome

Drugs & Therapeutics for Neuroleptic Malignant Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Neuroleptic Malignant Syndrome

Drug clinical trials:

Search ClinicalTrials for Neuroleptic Malignant Syndrome

Search NIH Clinical Center for Neuroleptic Malignant Syndrome

Search CenterWatch for Neuroleptic Malignant Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Neuroleptic Malignant Syndrome

Anatomical Context for Neuroleptic Malignant Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Neuroleptic Malignant Syndrome:

33
Liver, Tongue, Brain, Subthalamic nucleus

Animal Models for Neuroleptic Malignant Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Neuroleptic Malignant Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.7MB, NHLRC1, RYR3, RYR1, CHKB, DRD2
2MP:00053867.4NHLRC1, HTR3A, HTR2A, DRD2, CHKB, HTR1A
3MP:00053766.8NHLRC1, MB, HTR1A, HTR3A, DRD2, PIK3C2A

Publications for Neuroleptic Malignant Syndrome

Sources:
51PubMed
See all sources

Articles related to Neuroleptic Malignant Syndrome:

(show top 50)    (show all 542)
idTitleAuthorsYear
1
Neuroleptic malignant syndrome masked by cerebral malaria. (23704432)
2013
2
Hydrocephalus-induced neuroleptic malignant-like syndrome with reduced dopamine transporters. (23835636)
2013
3
Lethal neuroleptic malignant syndrome due to amisulpride. (23504701)
2013
4
Neuroleptic malignant syndrome following combination of sertraline and paroxetine: a case report. (23312145)
2013
5
Clozapine-induced neuroleptic malignant syndrome in an adolescent. (22897669)
2012
6
Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management. (22563571)
2012
7
Neuroleptic malignant syndrome versus serotonin syndrome: the search for a diagnostic tool. (21878660)
2011
8
Neuroleptic malignant syndrome secondary to aripiprazole initiation in a clozapine-intolerant patient. (20651315)
2010
9
Zuclopenthixol-induced neuroleptic malignant syndrome presenting as fever of unknown origin, hyperglycaemia and acute myocardial infarction in a 60-year-old man. (17965986)
2009
10
Neuroleptic malignant syndrome due to risperidone treatment in a child with Joubert syndrome. (19331262)
2009
11
Neuroleptic malignant syndrome from central nervous system insult: 4 cases and a novel treatment strategy. Clinical article. (19772404)
2009
12
A rare case of neuroleptic malignant syndrome presenting with serious hyperthermia treated with a non-invasive cooling device: a case report. (19830098)
2009
13
Neuroleptic malignant syndrome associated with atypical antipsychotic drugs. (19480467)
2009
14
Neuroleptic malignant syndrome without fever after addition of oxcarbazepine to long-term treatment with amisulpride. (18774435)
2008
15
Neuroleptic malignant syndrome variant in a patient receiving donepezil and olanzapine. (18212788)
2008
16
A case of 45,XO/47,XYY mosaicism with psychotic symptoms and neuroleptic malignant syndrome. (17478025)
2007
17
Aripiprazole and the neuroleptic malignant syndrome. (16678389)
2006
18
Subcutaneous apomorphine for neuroleptic malignant syndrome. (16877667)
2006
19
Neuroleptic malignant syndrome after the use of venlafaxine in a patient with generalized anxiety disorder. (16440077)
2006
20
Neuroleptic malignant syndrome: a case report. (16883152)
2006
21
Fluphenazine-induced neuroleptic malignant syndrome in a schizophrenic patient. (15840734)
2005
22
Clomipramine and neuroleptic malignant syndrome: literature on adverse reactions to psychotropic drugs continues to confuse. (15802729)
2005
23
Aripiprazole for agitation in a 13-year-old girl with neuroleptic malignant syndrome. (15971738)
2005
24
Neuroleptic malignant syndrome associated with risperidone in a male with early-onset schizophrenia. (16379503)
2005
25
Recognizing neuroleptic malignant syndrome. (15159345)
2004
26
A curious case of neuroleptic malignant syndrome. (15503743)
2004
27
Catatonia is a risk factor for neuroleptic malignant syndrome. (15641881)
2004
28
Neuroleptic malignant syndrome following cardiac surgery: successful treatment with dantrolene. (12965323)
2003
29
Neuroleptic malignant syndrome and low-dose olanzapine. (12668376)
2003
30
Neuroleptic malignant syndrome following administration of risperidone and lithium. (12826996)
2003
31
Neuroleptic malignant syndrome in Mexico. (14506509)
2003
32
Neuroleptic malignant syndrome: a case that may shed new light into the etiology and treatment. (12873338)
2003
33
Neuroleptic malignant syndrome in the critical care unit. (12441787)
2002
34
Quetiapine and neuroleptic malignant syndrome. (12420666)
2002
35
Clozapine-associated neuroleptic malignant syndrome. (12204041)
2002
36
Olanzapine and neuroleptic malignant syndrome. (12444237)
2002
37
Persistent fever in a case of typhoid--an unusual cause of neuroleptic malignant syndrome. (11225156)
2001
38
Neuroleptic malignant syndrome in pregnancy. (11704197)
2001
39
Neuroleptic malignant syndrome with antidepressant/antipsychotic drug combination. (11409001)
2001
40
Neuroleptic malignant syndrome induced by droperidol. (11406684)
2001
41
Case study. Risperidone-Induced neuroleptic malignant syndrome in an adolescent. (11191694)
2000
42
Recognition, assessment and management of neuroleptic malignant syndrome. (11016275)
2000
43
Catatonic and non-catatonic neuroleptic malignant syndrome. (11037384)
2000
44
Obtaining informed consent of patients at risk of neuroleptic malignant syndrome. (10970926)
2000
45
Neuroleptic malignant syndrome: a case report. (11957317)
1999
46
Neuroleptic malignant syndrome. (10778679)
1999
47
Repeated propofol anesthesia for a patient with a history of neuroleptic malignant syndrome. (10466342)
1999
48
Neuroleptic malignant syndrome with gangliosidosis type II. (9171913)
1997
49
Neuroleptic malignant syndrome associated with clozapine monotherapy. (8247922)
1993
50
An autopsy case of cerebellar degeneration following lithium intoxication with neuroleptic malignant syndrome. (8257473)
1993

Genetic Variations for Neuroleptic Malignant Syndrome

Expression for genes affiliated with Neuroleptic Malignant Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Neuroleptic Malignant Syndrome

Search GEO for disease gene expression data for Neuroleptic Malignant Syndrome.

Pathways for genes affiliated with Neuroleptic Malignant Syndrome

Sources:
38NCBI BioSystems Database, 50PharmGKB, 54Reactome, 52QIAGEN, 30KEGG
See all sources

Compounds for genes affiliated with Neuroleptic Malignant Syndrome

Sources:
11DrugBank, 45Novoseek, 29IUPHAR, 50PharmGKB, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 297)
idCompoundScoreTop Affiliating Genes
1Pipotiazine119.9DRD2, CYP2D6, HTR2A, HTR1A
2amperozide459.8HTR1A, DRD2, HTR2A, HTR3A
3mcpp459.8HTR3A, CYP2D6, HTR1A, HTR2A
4piperazine45 1110.8HTR2A, CYP2D6, DRD2, HTR1A
5granisetron45 1110.8DRD2, HTR3A, CYP2D6, HTR2A
6pindolol45 29 1111.8HTR3A, HTR2A, CYP2D6, HTR1A
7sertindole29 45 1111.7CYP2D6, HTR2A, HTR1A, DRD2
8trimipramine50 45 1111.7CYP2D6, DRD2, HTR2A, HTR1A
9ritanserin29 4510.7HTR3A, HTR1A, DRD2, HTR2A
10spiperone29 4510.7HTR3A, HTR2A, DRD2, HTR1A
11ipsapirone45 2910.7HTR1A, POMC, HTR2A, HTR3A
12buspirone45 29 1111.6HTR3A, DRD2, CYP2D6, HTR1A, HTR2A
13ropinirole45 1110.6HTR1A, CYP2D6, DRD2, HTR2A
14nefazodone45 50 1111.6HTR2A, CYP2D6, HTR1A, HTR3A
15iloperidone50 45 29 1112.6HTR1A, HTR3A, DRD2, HTR2A, CYP2D6
16aripiprazole29 50 45 11 2413.6DRD2, CYP2D6, HTR2A, HTR1A, HTR3A
17pimozide29 50 45 1112.6HTR2A, HTR1A, DRD2, CYP2D6
18ziprasidone50 29 45 1112.6HTR3A, HTR1A, CYP2D6, DRD2, HTR2A
19yohimbine45 29 2 1112.6HTR3A, DRD2, CYP2D6, HTR2A, HTR1A
20quetiapine45 50 29 11 2413.6DRD2, CYP2D6, HTR2A, HTR1A, HTR3A
21fenfluramine29 45 1111.5HTR3A, HTR1A, CYP2D6, POMC, HTR2A
22fluoxetine50 45 29 1112.5HTR3A, HTR2A, DRD2, CYP2D6, HTR1A
23lisuride29 45 1111.5HTR1A, HTR2A, DRD2, CYP2D6
24alpha-hydroxybutyrate459.5PIK3C2A, GPT, CHKB, MB
25succinylcholine45 29 1111.5RYR1, CHKB, MB, PIK3C2A
26chlorpromazine45 29 50 1112.4HTR1A, CYP2D6, DRD2, HTR2A, CHKB, HTR3A
27maoa459.4HTR2A, DRD2, POMC, HTR1A
28mirtazapine50 45 1111.3HTR3A, HTR2A, POMC, CYP2D6
29olanzapine50 45 29 11 2413.2CHKB, DRD2, HTR1A, CYP2D6, ANKK1, HTR2A
30halothane45 29 1111.2CHKB, RYR1, PIK3C2A, MB, CYP2D6
31thioridazine29 45 50 1112.2HTR2A, CYP2D6, HTR1A, DRD2
32dantrolene45 29 1111.1CHKB, PIK3C2A, MB, RYR1, RYR3
33bromocriptine29 45 1111.1DRD2, PIK3C2A, HTR1A, HTR2A, POMC
345-hydroxytryptamine459.1POMC, F2RL1, DRD2, HTR2A, HTR3A, HTR1A
35fluvastatin45 50 29 1112.0CYP2D6, GPT, CHKB, MB, PIK3C2A
36risperidone29 45 50 60 11 2413.8HTR1A, HTR3A, HTR2A, DRD2, CHKB, ANKK1
37cocaine45 119.7POMC, GPT, CYP2D6, MB, DRD2, PIK3C2A
38prednisolone45 29 1110.7MB, NPPB, PIK3C2A, CHKB, POMC, GPT
39clozapine45 29 50 1111.3HTR1A, HTR3A, HTR2A, DRD2, CHKB, ANKK1
40pravastatin45 50 29 11 2412.2CYP2D6, CHKB, CHKA, PIK3C2A, GPT, NPPB
41dopamine45 29 11 2411.2F2RL1, NPPB, CYP2D6, POMC, CHKB, DRD2
42atorvastatin45 50 29 11 2412.2CYP2D6, NPPB, PIK3C2A, CHKA, CHKB, GPT
43citrate458.0CPT2, POMC, CHKB, CHKA, PIK3C2A, MB
44thyroxine45 248.9MB, CHKA, GPT, PIK3C2A, POMC, CHKB
45haloperidol45 29 2 50 1111.7CYP2D6, POMC, DRD2, NPPB, HTR2A, HTR3A
46adenylate457.7CHKA, CPT2, MB, HTR1A, POMC, GPT
47norepinephrine45 11 249.5MB, HTR3A, HTR2A, DRD2, PIK3C2A, CHKB
48creatinine457.1PIK3C2A, CPT2, NPPB, MB, CHKA, CHKB
49acetylcholine45 50 29 11 2411.0RYR1, F2RL1, CYP2D6, POMC, MB, HTR1A
50glutamate456.8CHKA, CPT2, F2RL1, GPT, RYR1, CHKB

GO Terms for genes affiliated with Neuroleptic Malignant Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1junctional membrane complexGO:0303149.7RYR3, RYR1

Biological processes related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.2HTR1A, HTR2A
2negative regulation of synaptic transmission, glutamatergicGO:05196710.1DRD2, HTR2A
3regulation of dopamine secretionGO:01405910.0DRD2, HTR2A
4regulation of behaviorGO:05079510.0HTR2A, HTR1A
5cellular response to caffeineGO:0713139.9RYR3, RYR1
6serotonin receptor signaling pathwayGO:0072109.9HTR2A, HTR3A, HTR1A
7release of sequestered calcium ion into cytosolGO:0512099.9RYR1, DRD2, HTR2A
8positive regulation of urine volumeGO:0358109.8DRD2, NPPB
9positive regulation of renal sodium excretionGO:0358159.8DRD2, NPPB
10CDP-choline pathwayGO:0066579.7CHKB, CHKA
11cellular calcium ion homeostasisGO:0068749.6HTR2A, DRD2, RYR3
12positive regulation of ERK1 and ERK2 cascadeGO:0703749.5HTR2A, DRD2, F2RL1
13phosphatidylethanolamine biosynthetic processGO:0066469.2CHKB, CHKA

Molecular functions related to Neuroleptic Malignant Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1G-protein alpha-subunit bindingGO:0019659.9F2RL1, HTR2A
2serotonin receptor activityGO:0049939.8HTR1A, HTR3A, HTR2A
3ryanodine-sensitive calcium-release channel activityGO:0052199.7RYR3, RYR1
4calcium-release channel activityGO:0152789.6RYR3, RYR1
5choline kinase activityGO:0041039.6CHKB, CHKA
6serotonin bindingGO:0513789.5HTR2A, HTR3A
7ethanolamine kinase activityGO:0043059.5CHKA, CHKB
8drug bindingGO:0081449.1CYP2D6, CHKA, DRD2, HTR2A

Products for genes affiliated with Neuroleptic Malignant Syndrome

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Sources for Neuroleptic Malignant Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet