MCID: NRL007
MIFTS: 44

Neurologic Diseases malady

Neuronal diseases category

Summaries for Neurologic Diseases

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 The brain, spinal cord, and nerves make up the nervous system. together they control all the workings of the body. when something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. you can also have problems with your memory, senses, or mood. there are more than 600 neurologic diseases. major types include diseases caused by faulty genes, such as huntington's disease and muscular dystrophy problems with the way the nervous system develops, such as spina bifida degenerative diseases, where nerve cells are damaged or die, such as parkinson's disease and alzheimer's disease diseases of the blood vessels that supply the brain, such as stroke injuries to the spinal cord and brain seizure disorders, such as epilepsy cancer, such as brain tumors infections, such as meningitis

MalaCards: Neurologic Diseases is related to parkinson's disease and prion disease. An important gene associated with Neurologic Diseases is CNTF (ciliary neurotrophic factor), and among its related pathways are Disease and Nanog in Mammalian ESC Pluripotency. The compounds threonine and bio have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart.

Wikipedia:63 A neurological disorder is any disorder of the body nervous system. Structural, biochemical or... more...

Aliases & Classifications for Neurologic Diseases

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Sources:
63Wikipedia, 33MedlinePlus, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neurologic diseases 63 33 60


Related Diseases for Neurologic Diseases

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Neurologic Diseases:



Diseases related to neurologic diseases

Clinical Features for Neurologic Diseases

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Drugs & Therapeutics for Neurologic Diseases

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Neurologic Diseases

Drug clinical trials:

Search ClinicalTrials for Neurologic Diseases

Search NIH Clinical Center for Neurologic Diseases

Search CenterWatch for Neurologic Diseases

Genetic Tests for Neurologic Diseases

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Anatomical Context for Neurologic Diseases

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Sources:
32MalaCards
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MalaCards organs/tissues related to Neurologic Diseases:

32
Brain, Spinal cord, Heart, Testes, Liver, T cells, Bone marrow, Eye, Bone, Skin, Tongue, Cerebellum, Monocytes, Pituitary, Small intestine, Cortex

Animal Models for Neurologic Diseases or affiliated genes

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Publications for Neurologic Diseases

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Sources:
50PubMed
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Articles related to Neurologic Diseases:

(show top 50)    (show all 738)
idTitleAuthorsYear
1
Management of faecal incontinence and constipation in adults with central neurological diseases. (24420006)
2014
2
Crohn's disease: Is there a place for neurological screening? (24299027)
2014
3
Hypogonadism and neurological diseases. (23292617)
2013
4
Diagnostic and therapeutic potential of tetanus toxin-derivatives in neurological diseases. (23842888)
2013
5
Potential links between neurological disease and Tako-Tsubo cardiomyopathy: a literature review. (23608401)
2013
6
Reportable neurologic diseases in refugee camps in 19 countries. (22927678)
2012
7
Subacute myeloa89optic neuropathy, beriberi, and HTLVa89Ia89associated myelopathy: elucidation of some neurological diseases in Japan. (23222550)
2012
8
BehAset's disease: features of neurological involvement in a dedicated centre in Italy. (23009765)
2012
9
Adverse neurological outcomes in Nigerian children with sickle cell disease. (23129067)
2012
10
Rituximab in the treatment of three coexistent neurological autoimmune diseases: chronic inflammatory demyelinating polyradiculoneuropathy, Morvan syndrome and myasthenia gravis. (20462915)
2011
11
Neuraxial blockade in patients with preexisting spinal stenosis, lumbar disk disease, or prior spine surgery: efficacy and neurologic complications. (20861423)
2010
12
Serologic markers of neurologic diseases: the control groups. (20373356)
2010
13
Clinical, electrophysiological, and serum biochemical measures of progressive neurological and hepatic dysfunction in feline Niemann-Pick type C disease. (18614965)
2008
14
Stem cells and neurological diseases. (18181951)
2008
15
Ribonucleoprotein complexes in neurologic diseases. (18929657)
2008
16
Neurological manifestations and ATP7B mutations in Wilson's disease. (17897870)
2008
17
Urbach-Wiethe disease (lipoid proteinosis) with neurological involvement]. (17384547)
2007
18
Late neurological presentations of Wilson disease patients in French population and identification of 8 novel mutations in the ATP7B gene. (17317524)
2007
19
Highlights of the guidelines for screening of extracranial carotid artery disease: a statement for healthcare professionals from the Multidisciplinary Practice Guidelines Committee of the American Society of Neuroimaging; cosponsored by the Society of Vascular and Interventional Neurology. (17696620)
2007
20
A study of clinical, MRI and multimodality evoked potentials in neurologic Wilson disease. (17437607)
2007
21
Neurotensin: role in psychiatric and neurological diseases. (16891042)
2006
22
High-dose therapy for autoimmune neurologic diseases. (15725909)
2005
23
Analysis of Chlamydia pneumoniae-specific oligoclonal bands in multiple sclerosis and other neurologic diseases. (16146493)
2005
24
Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease. (15212822)
2004
25
Neurocristopathies presenting with neurologic abnormalities associated with Hirschsprung's disease. (12878302)
2003
26
Soluble urokinase receptor (uPAR, CD 87) is present in serum and cerebrospinal fluid in patients with neurologic diseases. (12161038)
2002
27
Neurologic presentation of Whipple disease: report of 12 cases and review of the literature. (12441901)
2002
28
Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases. (11413272)
2001
29
Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders. (11702213)
2001
30
The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin. (11709539)
2001
31
Sodium channels and neurological disease: insights from Scn8a mutations in the mouse. (11496924)
2001
32
Frequency of stroke in Europe: A collaborative study of population-based cohorts. ILSA Working Group and the Neurologic Diseases in the Elderly Research Group. Italian Longitudinal Study on Aging. (10854359)
2000
33
Frequency and impact of neurologic diseases in the elderly of Europe: A collaborative study of population-based cohorts. (10854353)
2000
34
Strategies for CABG patients with carotid artery disease and perioperative neurological complications. (11289501)
2000
35
Very high plasma leucine concentrations without neurological symptoms in a patient with classical maple syrup urine disease. (10947206)
2000
36
Cerebrospinal fluid analysis for the diagnosis of human immunodeficiency virus-related neurologic diseases. (10718543)
1999
37
alpha B-crystallin in neurological diseases]. (9125739)
1997
38
Immunization with the paraneoplastic encephalomyelitis antigen HuD does not cause neurologic disease in mice. (7477985)
1995
39
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. (8293279)
1993
40
Disseminated intravascular coagulation in adult-onset Still's disease with neurological, respiratory and hepatic sequelae. (8220844)
1993
41
Paraneoplastic syndromes: fads and facts (1) and neurological manifestations of malignant diseases (2) (1452572)
1992
42
Menkes disease: an X-linked neurological disorder of the copper metabolism. (1341968)
1992
43
Permanently locked-in syndrome in the neurologically impaired neonate: report of a case of Werdnig-Hoffmann disease. (1392039)
1992
44
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
45
Ethical aspects of unproved therapies in multiple sclerosis, amyotrophic lateral sclerosis, and other neurologic diseases. (11649670)
1984
46
Catecholamines and neurologic diseases (first of two parts). (166316)
1975
47
Cholinergic enzymatic activity of cerebrospinal fluid of patients with various neurologic diseases. (5125328)
1971
48
Hyperbaric oxygenation and "transbaric therapy" applied to neurologic diseases and other chronic diseases. (4861062)
1966
49
NEUROLOGIC MANIFESTATIONS OF COLLAGEN DISEASE: A REPORT OF FOUR CASES. (14224299)
1964
50
A study of cholinesterase and ali-esterase in various neurologic diseases. (13517490)
1958

Genetic Variations for Neurologic Diseases

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Expression for genes affiliated with Neurologic Diseases

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurologic Diseases

Search GEO for disease gene expression data for Neurologic Diseases.

Pathways for genes affiliated with Neurologic Diseases

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 12EMD Millipore, 59Tocris Bioscience, 37NCBI BioSystems Database
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Pathways related to Neurologic Diseases according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7PSMB3, STX1B, PRKACG, GSK3A, GSK3B
2
Hide members
10.7PSMB3, PRKACG, PLCD3, GSK3A, GSK3B
3
Translation Insulin regulation of translation
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10.7GSK3B, GSK3A, CNTF, PRKACG
4
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10.7GSK3B, GSK3A, PRKACG, PSMB3
5
Hide members
10.7PSMB3, PRKACG, PLCD3, GSK3B
6
Hide members
10.6GSK3B, GSK3A, GABRQ
7
Development Leptin signaling via PI3K-dependent pathway
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10.6PRKACG, GSK3A, GSK3B
8
G-protein signaling G-Protein alpha-i signaling cascades
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10.6GSK3B, GSK3A, PRKACG
9
Signal transduction cAMP signaling
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10.6PRKACG, GSK3A, GSK3B
1010.6PRKACG, GSK3A, GSK3B
1110.6GSK3A, GSK3B
12
Hide members
10.6GSK3B, GSK3A
13
Hide members
10.6GSK3B, GSK3A
14
Hide members
10.6GSK3B, GSK3A
15
Hide members
10.6GSK3B, GSK3A
16
Hide members
10.6GSK3B, GSK3A
17
Hide members
10.6GSK3B, GSK3A

Compounds for genes affiliated with Neurologic Diseases

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Sources:
44Novoseek, 59Tocris Bioscience
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Compounds related to Neurologic Diseases according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1threonine4410.7GSK3B, GSK3A, CNTF, PRKACG, MT-ND5
2bio5910.7GSK3B, GSK3A
3mebio5910.6GSK3A, GSK3B
4tws 1195910.6GSK3A, GSK3B
5bio-acetoxime5910.5GSK3A, GSK3B
6sb 2167635910.3GSK3A, GSK3B

GO Terms for genes affiliated with Neurologic Diseases

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16Gene Ontology
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Cellular components related to Neurologic Diseases according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.6GSK3B, GSK3A

Biological processes related to Neurologic Diseases according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of type B pancreatic cell developmentGO:200007710.7GSK3B, GSK3A
2negative regulation of glycogen (starch) synthase activityGO:200046610.6GSK3B, GSK3A
3apoptotic processGO:00691510.6PSMB3, PNMA5, PNMA1, PNMA3, PNMA2
4negative regulation of glycogen biosynthetic processGO:04571910.6GSK3B, GSK3A
5glycogen metabolic processGO:00597710.6GSK3B, GSK3A
6neurotransmitter transportGO:00683610.3STX1B, GABRQ

Molecular functions related to Neurologic Diseases according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tau-protein kinase activityGO:05032110.6GSK3B, GSK3A
2protein kinase A catalytic subunit bindingGO:03423610.3GSK3B, GSK3A

Products for genes affiliated with Neurologic Diseases

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neurologic Diseases

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet