MCID: NRL007
MIFTS: 41

Neurologic Diseases malady

Neuronal category

Summaries for Neurologic Diseases

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 The brain, spinal cord, and nerves make up the nervous system. together they control all the workings of the body. when something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. you can also have problems with your memory, senses, or mood. there are more than 600 neurologic diseases. major types include diseases caused by faulty genes, such as huntington's disease and muscular dystrophy problems with the way the nervous system develops, such as spina bifida degenerative diseases, where nerve cells are damaged or die, such as parkinson's disease and alzheimer's disease diseases of the blood vessels that supply the brain, such as stroke injuries to the spinal cord and brain seizure disorders, such as epilepsy cancer, such as brain tumors infections, such as meningitis

MalaCards: Neurologic Diseases is related to parkinson's disease and brain disease. An important gene associated with Neurologic Diseases is CNTF (ciliary neurotrophic factor), and among its related pathways are Disease and Nanog in Mammalian ESC Pluripotency. The compounds threonine and bio have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex.

Wikipedia:64 A neurological disorder is any disorder of the body nervous system. Structural, biochemical or... more...

Aliases & Classifications for Neurologic Diseases

Sources:
64Wikipedia, 34MedlinePlus, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

neurologic diseases 64 34 61


Related Diseases for Neurologic Diseases

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Neurologic Diseases:



Diseases related to neurologic diseases

Clinical Features for Neurologic Diseases

Drugs & Therapeutics for Neurologic Diseases

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Neurologic Diseases

Drug clinical trials:

Search ClinicalTrials for Neurologic Diseases

Search NIH Clinical Center for Neurologic Diseases

Search CenterWatch for Neurologic Diseases

Genetic Tests for Neurologic Diseases

Anatomical Context for Neurologic Diseases

Sources:
33MalaCards
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MalaCards organs/tissues related to Neurologic Diseases:

33
Whole blood, Brain, Cortex, Spinal cord, Small intestine, Skin, T cells, B cells, Tongue

Animal Models for Neurologic Diseases or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Neurologic Diseases

Sources:
51PubMed
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Articles related to Neurologic Diseases:

(show top 50)    (show all 301)
idTitleAuthorsYear
1
Application of array-based comparative genomic hybridization to pediatric neurologic diseases. (24339284)
2014
2
Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside. (24384539)
2013
3
Diagnostic and therapeutic potential of tetanus toxin-derivatives in neurological diseases. (23842888)
2013
4
Scavenger receptor b2 as a receptor for hand, foot, and mouth disease and severe neurological diseases. (22363322)
2012
5
Rare treatable neurologic diseases. (23677655)
2012
6
Scaffold protein Homer 1: implications for neurological diseases. (22749857)
2012
7
Toxicities of immunosuppressive treatment of autoimmune neurologic diseases. (22379461)
2011
8
Insomnia in central neurologic diseases--occurrence and management. (21481621)
2011
9
Screening for common neurologic diseases among Israeli adolescents. (20042693)
2010
10
Predominance of neurologic diseases in international aeromedical transportation. (19664804)
2009
11
Neuroprotection: extrapolating from neurologic diseases to the eye. (19464671)
2009
12
Stem cells and neurological diseases. (18181951)
2008
13
Ribavirin inhibits Borna disease virus proliferation and fatal neurological diseases in neonatally infected gerbils. (18778737)
2008
14
Conformational diseases: an umbrella for various neurological disorders with an impaired ubiquitin-proteasome system. (16226348)
2006
15
Targeting kinin receptors for the treatment of neurological diseases. (15853687)
2005
16
Estrogen and cytokines production - the possible cause of gender differences in neurological diseases. (15777251)
2005
17
Blood gene expression profiling of neurologic diseases: a pilot microarray study. (15710849)
2005
18
Characterization of the various forms of the Reelin protein in the cerebrospinal fluid of normal subjects and in neurological diseases. (15006702)
2004
19
Oral antispastic drugs in nonprogressive neurologic diseases: a systematic review. (15505149)
2004
20
Basic principles of immunotherapy for neurologic diseases. (12894378)
2003
21
Childhood autoimmune neurologic diseases of the central nervous system. (14743647)
2003
22
History of allergic disorders in common neurologic diseases in Japanese patients. (11886367)
2002
23
Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseases. (12476345)
2002
24
EFNS Task Force on Molecular Diagnosis of Neurologic Disorders: guidelines for the molecular diagnosis of inherited neurologic diseases. First of two parts. (11422426)
2001
25
Immunochemical determination of cellular prion protein in plasma from healthy subjects and patients with sporadic CJD or other neurologic diseases. (11316892)
2001
26
Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. (10854355)
2000
27
Frequency of stroke in Europe: A collaborative study of population-based cohorts. ILSA Working Group and the Neurologic Diseases in the Elderly Research Group. Italian Longitudinal Study on Aging. (10854359)
2000
28
Frequency and impact of neurologic diseases in the elderly of Europe: A collaborative study of population-based cohorts. (10854353)
2000
29
Alternative therapy use in neurologic diseases: use in brain tumor patients. (10025798)
1999
30
Determination of acetylcholine concentration in cerebrospinal fluid of patients with neurologic diseases. (8825278)
1996
31
Fever in neurologic diseases. (8698994)
1996
32
Neural cell adhesion proteins and neurological diseases. (7706205)
1994
33
Neuroimmunotherapy: a practical approach to the treatment of immune-mediated neurologic diseases. (7984835)
1994
34
Superoxide dismutase in cerebrospinal fluid in patients with neurological diseases]. (8334770)
1993
35
The hypothalamic lateral tuberal nucleus: normal anatomy and changes in neurological diseases. (1362279)
1992
36
Compensatory mechanisms in degenerative neurologic diseases. Insights from parkinsonism. (2012508)
1991
37
Determination of superoxide dismutase activity by the polarographic method of catalytic currents in the cerebrospinal fluid of aging brain and neurologic degenerative diseases. (1984240)
1991
38
A comparison of regulatory cells in spinal fluid and blood in patients with multiple sclerosis and other neurologic diseases. (1978261)
1990
39
Other neurologic diseases with dementia as a sequela. (3066461)
1988
40
Molecular genetic insights into neurologic diseases. (3551764)
1987
41
Thyrotropin releasing hormone levels in human cerebrospinal fluid in various neurologic diseases. (3082203)
1986
42
Isolation of paramyxoviruses from patients with chronic neurologic diseases. (7229441)
1981
43
Brainstem auditory evoked response in the diagnosis of pediatric neurologic diseases. (7195504)
1981
44
Are all degenerative neurologic diseases slow virus infections? (200528)
1977
45
Catecholamines and neurologic diseases (second of two parts). (125386)
1975
46
Bullae: a cutaneous sign of a variety of neurologic diseases. (4758735)
1973
47
Neurology: prenatal diagnosis of inherited neurologic diseases. (18730605)
1971
48
Inherited neurologic diseases of Ashkenazic Jewry: demographic data suggesting non-random gene frequencies. (5634002)
1967
49
Spinal-fluid gamma globulin in multiple sclerosis and other neurologic diseases. Electrophoretic patterns in 606 patients. (13718313)
1961
50
Roentgenologic study of the small intestine; dysfunction associated with neurologic diseases. (18921561)
1947

Genetic Variations for Neurologic Diseases

Expression for genes affiliated with Neurologic Diseases

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Neurologic Diseases

Search GEO for disease gene expression data for Neurologic Diseases.

Pathways for genes affiliated with Neurologic Diseases

Sources:
54Reactome, 52QIAGEN, 30KEGG, 12EMD Millipore, 60Tocris Bioscience, 38NCBI BioSystems Database
See all sources

Pathways related to Neurologic Diseases according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7PSMB3, STX1B, PRKACG, GSK3A, GSK3B
2
Hide members
10.7PSMB3, PRKACG, PLCD3, GSK3A, GSK3B
3
Translation Insulin regulation of translation
Hide members
10.7GSK3B, GSK3A, CNTF, PRKACG
4
Hide members
10.7GSK3B, GSK3A, PRKACG, PSMB3
5
Hide members
10.7PSMB3, PRKACG, PLCD3, GSK3B
6
Hide members
10.6GSK3B, GSK3A, GABRQ
7
Development Leptin signaling via PI3K-dependent pathway
Hide members
10.6PRKACG, GSK3A, GSK3B
8
G-protein signaling G-Protein alpha-i signaling cascades
Hide members
10.6GSK3B, GSK3A, PRKACG
9
Signal transduction cAMP signaling
Hide members
10.6PRKACG, GSK3A, GSK3B
1010.6PRKACG, GSK3A, GSK3B
1110.6GSK3A, GSK3B
12
Hide members
10.6GSK3B, GSK3A
13
Hide members
10.6GSK3B, GSK3A
14
Hide members
10.6GSK3B, GSK3A
15
Hide members
10.6GSK3B, GSK3A
16
Hide members
10.6GSK3B, GSK3A
17
Hide members
10.6GSK3B, GSK3A

Compounds for genes affiliated with Neurologic Diseases

Sources:
45Novoseek, 60Tocris Bioscience
See all sources

Compounds related to Neurologic Diseases according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1threonine4510.7GSK3B, GSK3A, CNTF, PRKACG, MT-ND5
2bio6010.7GSK3B, GSK3A
3mebio6010.6GSK3A, GSK3B
4tws 1196010.6GSK3A, GSK3B
5bio-acetoxime6010.5GSK3A, GSK3B
6sb 2167636010.3GSK3A, GSK3B

GO Terms for genes affiliated with Neurologic Diseases

Sources:
16Gene Ontology
See all sources

Cellular components related to Neurologic Diseases according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.6GSK3B, GSK3A

Biological processes related to Neurologic Diseases according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of type B pancreatic cell developmentGO:200007710.7GSK3B, GSK3A
2negative regulation of glycogen (starch) synthase activityGO:200046610.6GSK3B, GSK3A
3apoptotic processGO:00691510.6PSMB3, PNMA5, PNMA1, PNMA3, PNMA2
4negative regulation of glycogen biosynthetic processGO:04571910.6GSK3B, GSK3A
5glycogen metabolic processGO:00597710.6GSK3B, GSK3A
6neurotransmitter transportGO:00683610.3STX1B, GABRQ

Molecular functions related to Neurologic Diseases according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tau-protein kinase activityGO:05032110.6GSK3B, GSK3A
2protein kinase A catalytic subunit bindingGO:03423610.3GSK3B, GSK3A

Products for genes affiliated with Neurologic Diseases

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neurologic Diseases

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet