MCID: NRL007
MIFTS: 45

Neurologic Diseases malady

Neuronal diseases category
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Summaries for Neurologic Diseases

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 The brain, spinal cord, and nerves make up the nervous system. together they control all the workings of the body. when something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. you can also have problems with your memory, senses, or mood. there are more than 600 neurologic diseases. major types include diseases caused by faulty genes, such as huntington's disease and muscular dystrophy problems with the way the nervous system develops, such as spina bifida degenerative diseases, where nerve cells are damaged or die, such as parkinson's disease and alzheimer's disease diseases of the blood vessels that supply the brain, such as stroke injuries to the spinal cord and brain seizure disorders, such as epilepsy cancer, such as brain tumors infections, such as meningitis

MalaCards: Neurologic Diseases is related to neuropathy and multiple sclerosis. An important gene associated with Neurologic Diseases is ASPA (aspartoacylase), and among its related pathways are AMPK Enzyme Complex Pathway and Monoamine GPCRs. The compounds dexmedetomidine hydrochloride and [3h]rx821002 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Wikipedia:65 A neurological disorder is any disorder of the body nervous system. Structural, biochemical or... more...

Aliases & Classifications for Neurologic Diseases

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Sources:
65Wikipedia, 34MedlinePlus, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neurologic diseases 65 34 62


Related Diseases for Neurologic Diseases

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Neurologic Diseases:



Diseases related to neurologic diseases

Symptoms for Neurologic Diseases

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Drugs & Therapeutics for Neurologic Diseases

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Neurologic Diseases

Search NIH Clinical Center for Neurologic Diseases

Genetic Tests for Neurologic Diseases

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Anatomical Context for Neurologic Diseases

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33MalaCards
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MalaCards organs/tissues related to Neurologic Diseases:

33
Brain, Spinal cord, Testes, T cells, Cortex, Pituitary, Small intestine, Monocytes, Skin, Eye, Tongue, Liver, Cerebellum

Animal Models for Neurologic Diseases or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Neurologic Diseases:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6ADRA2C, ADRA2B, MPZ, HSPB8, SPR
2MP:00053867.4SPR, MPZ, ADRA2B, ADRA2C, ASPA
3MP:00107687.2ASPA, ADRA2C, ADRA2B, MPZ, HSPB8, SPR

Publications for Neurologic Diseases

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52PubMed
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Articles related to Neurologic Diseases:

(show top 50)    (show all 428)
idTitleAuthorsYear
1
Management of faecal incontinence and constipation in adults with central neurological diseases. (24420006)
2014
2
Aicardi-Goutieres syndrome, a rare neurological disease in children: a new autoimmune disorder? (22940555)
2013
3
Hypogonadism and neurological diseases. (23292617)
2013
4
Sarcopenia or muscle modifications in neurologic diseases: a lexical or patophysiological difference? (23575206)
2013
5
Reportable neurologic diseases in refugee camps in 19 countries. (22927678)
2012
6
West Nile virus neurologic disease in humans, South Africa, September 2008-may 2009. (23171668)
2012
7
Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult. (22889536)
2012
8
Models of neurological disease (substance abuse): self-administration in monkeys. (22382996)
2011
9
Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes. (20382883)
2010
10
HIV/AIDS and neurologic diseases. (20876461)
2010
11
Pathogenetic mechanisms in hereditary dysfunctions of complex I of the respiratory chain in neurological diseases. (19210954)
2009
12
Neurologic diseases in llamas and alpacas. (19460647)
2009
13
Predominance of neurologic diseases in international aeromedical transportation. (19664804)
2009
14
Neurologic disease and vitamin B12 deficiency. (17920997)
2007
15
Genetic variability in expression of proteins and the risk of sporadic neurologic diseases. (17325268)
2007
16
Mutations in structural genes of complex I associated with neurological diseases. (17274530)
2006
17
Neurotensin: role in psychiatric and neurological diseases. (16891042)
2006
18
Inhibition of poly(adenosine diphosphate-ribose) polymerase (PARP) in experimental models of neurologic diseases: cell death prevention. (16374324)
2005
19
Intermittent exotropia increasing with near fixation: a "soft" sign of neurological disease. (16299124)
2005
20
Genetically based neurologic diseases-unraveling the genotype-phenotype conundrum. (14631197)
2003
21
Basic principles of immunotherapy for neurologic diseases. (12894378)
2003
22
Surveys of complementary and alternative medicine: Part V. Use of alternative and complementary therapies for psychiatric and neurologic diseases. (11890442)
2002
23
EFNS Task Force on Molecular Diagnosis of Neurologic Disorders: guidelines for the molecular diagnosis of inherited neurologic diseases. First of two parts. (11422426)
2001
24
Immunochemical determination of cellular prion protein in plasma from healthy subjects and patients with sporadic CJD or other neurologic diseases. (11316892)
2001
25
Chemokines in chronic progressive neurological diseases: HTLV-1 associated myelopathy and multiple sclerosis. (10190696)
1999
26
A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease? (10484774)
1999
27
The role of cell adhesion molecules in certain neurological diseases]. (10358837)
1998
28
Ion channel mutations in mouse models of inherited neurological disease. (9562526)
1997
29
Severe hyponatremia as poor prognostic factor in childhood neurologic diseases. (9349678)
1997
30
Intravenous immune globulin therapy for neurologic diseases. (9139559)
1997
31
Immunization with the paraneoplastic encephalomyelitis antigen HuD does not cause neurologic disease in mice. (7477985)
1995
32
Role of immune activation and cytokine expression in HIV-1-associated neurologic diseases. (8748077)
1995
33
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. (8293279)
1993
34
Microglia in degenerative neurological disease. (8423066)
1993
35
Serum and CSF levels of soluble intercellular adhesion molecule-1 (ICAM-1) in inflammatory neurologic diseases. (8105425)
1993
36
Suicide and patients with neurologic diseases. Methodologic problems. (1449409)
1992
37
Compensatory mechanisms in degenerative neurologic diseases. Insights from parkinsonism. (2012508)
1991
38
Studies of neuron-specific enolase levels in serum and cerebrospinal fluid of children with neurological diseases. (2342156)
1990
39
Fibromuscular dysplasia of the internal carotid artery: an unusual cause of reversible ischemic neurologic disease. (3766038)
1986
40
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
41
Neurologic diseases. (3000543)
1985
42
Quantitative CSF IgG measurements in multiple sclerosis and other neurologic diseases. An update. (6860176)
1983
43
Morphological abnormalities of erythrocyte membrane in the hereditary neurological disease with chorea, areflexia and acanthocytosis. (6216328)
1982
44
Isolation of paramyxoviruses from patients with chronic neurologic diseases. (7229441)
1981
45
Brainstem auditory evoked response in the diagnosis of pediatric neurologic diseases. (7195504)
1981
46
Hereditary neurological disease with acanthocytosis. A new syndrome. (5677189)
1968
47
Spinal-fluid gamma globulin in multiple sclerosis and other neurologic diseases. Electrophoretic patterns in 606 patients. (13718313)
1961
48
Neurologic diseases in infancy and childhood: summary of seminar. (13431321)
1957
49
Cortisone in neurologic diseases. (15440934)
1950
50
Roentgenologic study of the small intestine; dysfunction associated with neurologic diseases. (18921561)
1947

Variations for Neurologic Diseases

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Expression for genes affiliated with Neurologic Diseases

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurologic Diseases

Search GEO for disease gene expression data for Neurologic Diseases.

Pathways for genes affiliated with Neurologic Diseases

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 55Reactome, 51PharmGKB
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Compounds for genes affiliated with Neurologic Diseases

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Sources:
61Tocris Bioscience, 29IUPHAR, 45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Neurologic Diseases according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1dexmedetomidine hydrochloride619.6ADRA2C, ADRA2B
2[3h]rx821002299.6ADRA2C, ADRA2B
3rx821002299.6ADRA2C, ADRA2B
4arc-239299.6ADRA2C, ADRA2B
5brl 44408299.6ADRA2C, ADRA2B
6[3h]mk-912299.6ADRA2B, ADRA2C
7brl 44408 maleate619.6ADRA2B, ADRA2C
8atipamezole hydrochloride619.6ADRA2C, ADRA2B
9jp 1302 dihydrochloride619.6ADRA2C, ADRA2B
10medetomidine hydrochloride619.6ADRA2C, ADRA2B
11(plusmn)-adrenaline299.6ADRA2B, ADRA2C
12[3h]rauwolscine299.6ADRA2B, ADRA2C
13xylazine45 2910.6ADRA2B, ADRA2C
14tizanidine45 1110.5ADRA2C, ADRA2B
15guanfacine29 45 1111.5ADRA2B, ADRA2C
16wb 4101299.5ADRA2B, ADRA2C
17rauwolscine299.5ADRA2C, ADRA2B
18(-)-noradrenaline299.5ADRA2C, ADRA2B
19spiroxatrine45 2910.5ADRA2B, ADRA2C
20dexmedetomidine45 51 29 1112.5ADRA2C, ADRA2B
21fenoldopam45 1110.5ADRA2C, ADRA2B
22oxymetazoline45 29 1111.5ADRA2C, ADRA2B
23brimonidine45 29 1111.5ADRA2B, ADRA2C
24phenoxybenzamine45 1110.5ADRA2C, ADRA2B
25roxindole29 4510.5ADRA2C, ADRA2B
26terguride45 2910.5ADRA2B, ADRA2C
27phentolamine45 29 1111.5ADRA2C, ADRA2B
28ropinirole45 1110.5ADRA2C, ADRA2B
29lisuride45 29 1111.5ADRA2B, ADRA2C
30pergolide45 29 1111.5ADRA2C, ADRA2B
31paliperidone45 1110.5ADRA2C, ADRA2B
32pramipexole45 29 51 1112.5ADRA2B, ADRA2C
33asenapine29 1110.5ADRA2C, ADRA2B
34cabergoline45 29 1111.4ADRA2C, ADRA2B
35doxepin45 29 51 1112.4ADRA2B, ADRA2C
36prazosin45 29 51 1112.4ADRA2C, ADRA2B
37aripiprazole29 45 51 24 1113.4ADRA2C, ADRA2B
38ziprasidone29 51 45 1112.4ADRA2C, ADRA2B
39yohimbine45 3 29 1112.4ADRA2C, ADRA2B
40apomorphine29 45 1111.4ADRA2C, ADRA2B
41quetiapine45 51 29 24 1113.3ADRA2B, ADRA2C
42bromocriptine45 29 1111.3ADRA2C, ADRA2B
43chlorpromazine29 45 51 1112.3ADRA2C, ADRA2B
44methamphetamine45 51 1111.2ADRA2B, ADRA2C
45risperidone45 51 29 61 24 1114.2ADRA2C, ADRA2B
46clonidine45 51 29 1112.1ADRA2C, ADRA2B
47olanzapine45 51 29 24 1113.0ADRA2B, ADRA2C
48norepinephrine45 24 1110.9SPR, ADRA2B, ADRA2C
49clozapine45 29 51 1111.8ADRA2C, ADRA2B
50glutamate458.7ASPA, ADRA2B, MPZ

GO Terms for genes affiliated with Neurologic Diseases

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16Gene Ontology
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Biological processes related to Neurologic Diseases according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPK activity by adrenergic receptor signaling pathwayGO:0718839.3ADRA2C, ADRA2B
2epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:0356259.2ADRA2C, ADRA2B
3negative regulation of epinephrine secretionGO:0328119.2ADRA2C, ADRA2B
4negative regulation of norepinephrine secretionGO:0107009.1ADRA2B, ADRA2C
5female pregnancyGO:0075659.1ADRA2C, ADRA2B
6activation of protein kinase B activityGO:0321489.0ADRA2C, ADRA2B
7positive regulation of neuron differentiationGO:0456668.8ADRA2C, ADRA2B

Molecular functions related to Neurologic Diseases according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:0513799.1ADRA2C, ADRA2B
2alpha2-adrenergic receptor activityGO:0049388.8ADRA2C, ADRA2B

Products for genes affiliated with Neurologic Diseases

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Sources for Neurologic Diseases

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet