MCID: NRL007
MIFTS: 44

Neurologic Diseases malady

Neuronal diseases category

Summaries for Neurologic Diseases

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 The brain, spinal cord, and nerves make up the nervous system. together they control all the workings of the body. when something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. you can also have problems with your memory, senses, or mood. there are more than 600 neurologic diseases. major types include diseases caused by faulty genes, such as huntington's disease and muscular dystrophy problems with the way the nervous system develops, such as spina bifida degenerative diseases, where nerve cells are damaged or die, such as parkinson's disease and alzheimer's disease diseases of the blood vessels that supply the brain, such as stroke injuries to the spinal cord and brain seizure disorders, such as epilepsy cancer, such as brain tumors infections, such as meningitis

MalaCards: Neurologic Diseases is related to parkinson's disease and prion disease. An important gene associated with Neurologic Diseases is CNTF (ciliary neurotrophic factor), and among its related pathways are Disease and Nanog in Mammalian ESC Pluripotency. The compounds threonine and bio have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart.

Wikipedia:63 A neurological disorder is any disorder of the body nervous system. Structural, biochemical or... more...

Aliases & Classifications for Neurologic Diseases

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Sources:
63Wikipedia, 33MedlinePlus, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neurologic diseases 63 33 60


Related Diseases for Neurologic Diseases

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Neurologic Diseases:



Diseases related to neurologic diseases

Clinical Features for Neurologic Diseases

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Drugs & Therapeutics for Neurologic Diseases

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Neurologic Diseases

Drug clinical trials:

Search ClinicalTrials for Neurologic Diseases

Search NIH Clinical Center for Neurologic Diseases

Search CenterWatch for Neurologic Diseases

Genetic Tests for Neurologic Diseases

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Anatomical Context for Neurologic Diseases

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32MalaCards
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MalaCards organs/tissues related to Neurologic Diseases:

32
Brain, Spinal cord, Heart, Testes, Liver, T cells, Bone, Eye, Skin, Bone marrow, Tongue, Monocytes, Small intestine, Cerebellum, Cortex, Pituitary

Animal Models for Neurologic Diseases or affiliated genes

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Publications for Neurologic Diseases

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Sources:
50PubMed
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Articles related to Neurologic Diseases:

(show top 50)    (show all 738)
idTitleAuthorsYear
1
Angiotensinogen promoter and angiotensinogen II receptor type 1 gene polymorphisms and incidence of ischemic stroke and neurologic phenotype in Fabry disease. (24020479)
2013
2
Parsing out reality from genetically engineered mouse models of neurologic diseases. (22487881)
2012
3
Burden of disease and unmet needs in tuberous sclerosis complex with neurological manifestations: systematic review. (21692602)
2011
4
Toxicities of immunosuppressive treatment of autoimmune neurologic diseases. (22379461)
2011
5
Prognostic significance of neurologic examination findings in Wilson disease. (21641265)
2011
6
Hirschsprung's disease in the neurologically challenged child. (22191188)
2011
7
Neurological Wilson's disease with refractory rickets. (21648288)
2011
8
Natural progression of neurological disease in mucopolysaccharidosis type II. (21518713)
2011
9
Multi-system neurological disease is common in patients with OPA1 mutations. (20157015)
2010
10
A somatic NLRP3 mutation as a cause of a sporadic case of chronic infantile neurologic, cutaneous, articular syndrome/neonatal-onset multisystem inflammatory disease: Novel evidence of the role of low-level mosaicism as the pathophysiologic mechanism underlying mendelian inherited diseases. (20131270)
2010
11
Novel mutations affecting the Na, K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevity. (19455355)
2009
12
Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases]. (20025128)
2009
13
Estimation of virological and immunological parameters in subjects from South India infected with human immunodeficiency virus type 1 clade C and correlation of findings with occurrence of neurological disease. (19031329)
2009
14
VEGF and mRNA VEGF expression in CSF from BehAset's disease with neurological involvement. (19493574)
2009
15
Unaltered neurological disease and mortality in CXCR3-deficient mice infected intracranially with lymphocytic choriomeningitis virus-Armstrong. (19115931)
2008
16
Neurologic disease and vitamin B12 deficiency. (17920997)
2007
17
HTLV-I and neurological disease: from tropical spastic paraparesis to HTLV-I-associated myelopathy: what next? (18090720)
2007
18
Sera of patients with celiac disease and neurologic disorders evoke a mitochondrial-dependent apoptosis in vitro. (17631142)
2007
19
Folate-responsive neurologic diseases. (18021918)
2007
20
Rift Valley fever virus lacking NSm proteins retains high virulence in vivo and may provide a model of human delayed onset neurologic disease. (17412386)
2007
21
Guidelines for screening of extracranial carotid artery disease: a statement for healthcare professionals from the multidisciplinary practice guidelines committee of the American Society of Neuroimaging; cosponsored by the Society of Vascular and Interventional Neurology. (17238868)
2007
22
The genetics of Parkinson disease: Implications for neurological care. (16932540)
2006
23
Inhibition of poly(adenosine diphosphate-ribose) polymerase (PARP) in experimental models of neurologic diseases: cell death prevention. (16374324)
2005
24
Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment. (15740174)
2005
25
Molecular neurology of prion disease. (15965195)
2005
26
Basic principles of immunotherapy for neurologic diseases. (12894378)
2003
27
EFNS Task Force on Molecular Diagnosis of Neurologic Disorders: guidelines for the molecular diagnosis of inherited neurologic diseases. Second of two parts. (11554904)
2001
28
Cystatin C and cathepsin B in CSF from patients with inflammatory neurologic diseases. (11134381)
2000
29
Nidovirus infections: experimental model systems of human neurologic diseases. (10604745)
1999
30
Free radicals in inflammatory neurological disease: increased lipid peroxidation and haptoglobin levels in Guillain BarrAc syndrome. (9540301)
1998
31
Fever in neurologic diseases. (8698994)
1996
32
Role of immune activation and cytokine expression in HIV-1-associated neurologic diseases. (8748077)
1995
33
Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases. (8051562)
1994
34
Superoxide dismutase in cerebrospinal fluid in patients with neurological diseases]. (8334770)
1993
35
Suicide and patients with neurologic diseases. Methodologic problems. (1449409)
1992
36
Age-related changes in the proportion of amyloid precursor protein mRNAs in Alzheimer's disease and other neurological disorders. (1331685)
1992
37
Neurologic diseases in pregnancy. (1484659)
1992
38
Anti-CNS antibodies in childhood neurologic diseases. (2739881)
1989
39
Neurological and neuromuscular disease. (3942678)
1986
40
Free light chains in neurologic diseases: first reports. (3086769)
1986
41
Neurological involvement in type 1 (adult) Gaucher's disease. (3981177)
1985
42
Isolation of paramyxoviruses from patients with chronic neurologic diseases. (7229441)
1981
43
Clinical experiences with the use of an automated perimeter (Octopus) in the diagnosis and management of patients with glaucoma and neurologic diseases. (233862)
1979
44
Optic nerve hypoplasia: a benign entity simulating acquired neurological disease. (553389)
1979
45
Are all degenerative neurologic diseases slow virus infections? (200528)
1977
46
Circulating IgE, allergy and multiple sclerosis. Serum levels of IgE, other immunoglobulins and complement (C's) in patients with multiple sclerosis in exacerbation and other neurologic diseases. (1251679)
1976
47
Nuclear medicine and ultrasound in the evaluation of neurologic diseases. (1108207)
1975
48
The possible role of pleuropneumonia-like organisms in neurological disease. (4389629)
1968
49
Inherited neurologic diseases of Ashkenazic Jewry: demographic data suggesting non-random gene frequencies. (5634002)
1967
50
Retinal disease in neurology. (4285231)
1965

Genetic Variations for Neurologic Diseases

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Expression for genes affiliated with Neurologic Diseases

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurologic Diseases

Search GEO for disease gene expression data for Neurologic Diseases.

Pathways for genes affiliated with Neurologic Diseases

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 12EMD Millipore, 59Tocris Bioscience, 37NCBI BioSystems Database
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Pathways related to Neurologic Diseases according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7PSMB3, STX1B, PRKACG, GSK3A, GSK3B
2
Hide members
10.7PSMB3, PRKACG, PLCD3, GSK3A, GSK3B
3
Translation Insulin regulation of translation
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10.7GSK3B, GSK3A, CNTF, PRKACG
4
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10.7GSK3B, GSK3A, PRKACG, PSMB3
5
Hide members
10.7PSMB3, PRKACG, PLCD3, GSK3B
6
Hide members
10.6GSK3B, GSK3A, GABRQ
7
Development Leptin signaling via PI3K-dependent pathway
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10.6PRKACG, GSK3A, GSK3B
8
G-protein signaling G-Protein alpha-i signaling cascades
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10.6GSK3B, GSK3A, PRKACG
9
Signal transduction cAMP signaling
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10.6PRKACG, GSK3A, GSK3B
1010.6PRKACG, GSK3A, GSK3B
1110.6GSK3A, GSK3B
12
Hide members
10.6GSK3B, GSK3A
13
Hide members
10.6GSK3B, GSK3A
14
Hide members
10.6GSK3B, GSK3A
15
Hide members
10.6GSK3B, GSK3A
16
Hide members
10.6GSK3B, GSK3A
17
Hide members
10.6GSK3B, GSK3A

Compounds for genes affiliated with Neurologic Diseases

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Sources:
44Novoseek, 59Tocris Bioscience
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Compounds related to Neurologic Diseases according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1threonine4410.7GSK3B, GSK3A, CNTF, PRKACG, MT-ND5
2bio5910.7GSK3B, GSK3A
3mebio5910.6GSK3A, GSK3B
4tws 1195910.6GSK3A, GSK3B
5bio-acetoxime5910.5GSK3A, GSK3B
6sb 2167635910.3GSK3A, GSK3B

GO Terms for genes affiliated with Neurologic Diseases

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16Gene Ontology
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Cellular components related to Neurologic Diseases according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.6GSK3B, GSK3A

Biological processes related to Neurologic Diseases according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of type B pancreatic cell developmentGO:200007710.7GSK3B, GSK3A
2negative regulation of glycogen (starch) synthase activityGO:200046610.6GSK3B, GSK3A
3apoptotic processGO:00691510.6PSMB3, PNMA5, PNMA1, PNMA3, PNMA2
4negative regulation of glycogen biosynthetic processGO:04571910.6GSK3B, GSK3A
5glycogen metabolic processGO:00597710.6GSK3B, GSK3A
6neurotransmitter transportGO:00683610.3STX1B, GABRQ

Molecular functions related to Neurologic Diseases according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tau-protein kinase activityGO:05032110.6GSK3B, GSK3A
2protein kinase A catalytic subunit bindingGO:03423610.3GSK3B, GSK3A

Products for genes affiliated with Neurologic Diseases

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neurologic Diseases

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet