MCID: NRL007
MIFTS: 45

Neurologic Diseases malady

Neuronal diseases category

Summaries for Neurologic Diseases

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 The brain, spinal cord, and nerves make up the nervous system. together they control all the workings of the body. when something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. you can also have problems with your memory, senses, or mood. there are more than 600 neurologic diseases. major types include diseases caused by faulty genes, such as huntington's disease and muscular dystrophy problems with the way the nervous system develops, such as spina bifida degenerative diseases, where nerve cells are damaged or die, such as parkinson's disease and alzheimer's disease diseases of the blood vessels that supply the brain, such as stroke injuries to the spinal cord and brain seizure disorders, such as epilepsy cancer, such as brain tumors infections, such as meningitis

MalaCards: Neurologic Diseases is related to neuropathy and multiple sclerosis. An important gene associated with Neurologic Diseases is ASPA (aspartoacylase), and among its related pathways are AMPK Enzyme Complex Pathway and Monoamine GPCRs. The compounds dexmedetomidine hydrochloride and [3h]rx821002 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Wikipedia:66 A neurological disorder is any disorder of the body nervous system. Structural, biochemical or... more...

Aliases & Classifications for Neurologic Diseases

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Sources:
66Wikipedia, 35MedlinePlus, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neurologic diseases 66 35 63


Related Diseases for Neurologic Diseases

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Neurologic Diseases:



Diseases related to neurologic diseases

Symptoms for Neurologic Diseases

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Drugs & Therapeutics for Neurologic Diseases

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Neurologic Diseases

Drug clinical trials:

Search ClinicalTrials for Neurologic Diseases

Search NIH Clinical Center for Neurologic Diseases

Search CenterWatch for Neurologic Diseases

Genetic Tests for Neurologic Diseases

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Anatomical Context for Neurologic Diseases

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34MalaCards
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MalaCards organs/tissues related to Neurologic Diseases:

34
Brain, Spinal cord, Testes, T cells, Cortex, Pituitary, Small intestine, Monocytes, Skin, Eye, Tongue, Liver, Cerebellum

Animal Models for Neurologic Diseases or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Neurologic Diseases:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6ADRA2C, ADRA2B, MPZ, HSPB8, SPR
2MP:00053867.4SPR, MPZ, ADRA2B, ADRA2C, ASPA
3MP:00107687.2ASPA, ADRA2C, ADRA2B, MPZ, HSPB8, SPR

Publications for Neurologic Diseases

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53PubMed
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Articles related to Neurologic Diseases:

(show top 50)    (show all 428)
idTitleAuthorsYear
1
Management of faecal incontinence and constipation in adults with central neurological diseases. (24420006)
2014
2
Aicardi-Goutieres syndrome, a rare neurological disease in children: a new autoimmune disorder? (22940555)
2013
3
Hypogonadism and neurological diseases. (23292617)
2013
4
Sarcopenia or muscle modifications in neurologic diseases: a lexical or patophysiological difference? (23575206)
2013
5
Reportable neurologic diseases in refugee camps in 19 countries. (22927678)
2012
6
West Nile virus neurologic disease in humans, South Africa, September 2008-may 2009. (23171668)
2012
7
Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult. (22889536)
2012
8
Models of neurological disease (substance abuse): self-administration in monkeys. (22382996)
2011
9
Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes. (20382883)
2010
10
HIV/AIDS and neurologic diseases. (20876461)
2010
11
Pathogenetic mechanisms in hereditary dysfunctions of complex I of the respiratory chain in neurological diseases. (19210954)
2009
12
Neurologic diseases in llamas and alpacas. (19460647)
2009
13
Predominance of neurologic diseases in international aeromedical transportation. (19664804)
2009
14
Neurologic disease and vitamin B12 deficiency. (17920997)
2007
15
Genetic variability in expression of proteins and the risk of sporadic neurologic diseases. (17325268)
2007
16
Mutations in structural genes of complex I associated with neurological diseases. (17274530)
2006
17
Neurotensin: role in psychiatric and neurological diseases. (16891042)
2006
18
Inhibition of poly(adenosine diphosphate-ribose) polymerase (PARP) in experimental models of neurologic diseases: cell death prevention. (16374324)
2005
19
Intermittent exotropia increasing with near fixation: a "soft" sign of neurological disease. (16299124)
2005
20
Genetically based neurologic diseases-unraveling the genotype-phenotype conundrum. (14631197)
2003
21
Basic principles of immunotherapy for neurologic diseases. (12894378)
2003
22
Surveys of complementary and alternative medicine: Part V. Use of alternative and complementary therapies for psychiatric and neurologic diseases. (11890442)
2002
23
EFNS Task Force on Molecular Diagnosis of Neurologic Disorders: guidelines for the molecular diagnosis of inherited neurologic diseases. First of two parts. (11422426)
2001
24
Immunochemical determination of cellular prion protein in plasma from healthy subjects and patients with sporadic CJD or other neurologic diseases. (11316892)
2001
25
Chemokines in chronic progressive neurological diseases: HTLV-1 associated myelopathy and multiple sclerosis. (10190696)
1999
26
A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease? (10484774)
1999
27
The role of cell adhesion molecules in certain neurological diseases]. (10358837)
1998
28
Ion channel mutations in mouse models of inherited neurological disease. (9562526)
1997
29
Severe hyponatremia as poor prognostic factor in childhood neurologic diseases. (9349678)
1997
30
Intravenous immune globulin therapy for neurologic diseases. (9139559)
1997
31
Immunization with the paraneoplastic encephalomyelitis antigen HuD does not cause neurologic disease in mice. (7477985)
1995
32
Role of immune activation and cytokine expression in HIV-1-associated neurologic diseases. (8748077)
1995
33
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. (8293279)
1993
34
Microglia in degenerative neurological disease. (8423066)
1993
35
Serum and CSF levels of soluble intercellular adhesion molecule-1 (ICAM-1) in inflammatory neurologic diseases. (8105425)
1993
36
Suicide and patients with neurologic diseases. Methodologic problems. (1449409)
1992
37
Compensatory mechanisms in degenerative neurologic diseases. Insights from parkinsonism. (2012508)
1991
38
Studies of neuron-specific enolase levels in serum and cerebrospinal fluid of children with neurological diseases. (2342156)
1990
39
Fibromuscular dysplasia of the internal carotid artery: an unusual cause of reversible ischemic neurologic disease. (3766038)
1986
40
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
41
Neurologic diseases. (3000543)
1985
42
Quantitative CSF IgG measurements in multiple sclerosis and other neurologic diseases. An update. (6860176)
1983
43
Morphological abnormalities of erythrocyte membrane in the hereditary neurological disease with chorea, areflexia and acanthocytosis. (6216328)
1982
44
Isolation of paramyxoviruses from patients with chronic neurologic diseases. (7229441)
1981
45
Brainstem auditory evoked response in the diagnosis of pediatric neurologic diseases. (7195504)
1981
46
Hereditary neurological disease with acanthocytosis. A new syndrome. (5677189)
1968
47
Spinal-fluid gamma globulin in multiple sclerosis and other neurologic diseases. Electrophoretic patterns in 606 patients. (13718313)
1961
48
Neurologic diseases in infancy and childhood: summary of seminar. (13431321)
1957
49
Cortisone in neurologic diseases. (15440934)
1950
50
Roentgenologic study of the small intestine; dysfunction associated with neurologic diseases. (18921561)
1947

Variations for Neurologic Diseases

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Expression for genes affiliated with Neurologic Diseases

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurologic Diseases

Search GEO for disease gene expression data for Neurologic Diseases.

Pathways for genes affiliated with Neurologic Diseases

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB
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Compounds for genes affiliated with Neurologic Diseases

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Sources:
62Tocris Bioscience, 30IUPHAR, 46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Neurologic Diseases according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1dexmedetomidine hydrochloride629.6ADRA2C, ADRA2B
2[3h]rx821002309.6ADRA2C, ADRA2B
3rx821002309.6ADRA2C, ADRA2B
4arc-239309.6ADRA2C, ADRA2B
5brl 44408309.6ADRA2C, ADRA2B
6[3h]mk-912309.6ADRA2B, ADRA2C
7brl 44408 maleate629.6ADRA2B, ADRA2C
8atipamezole hydrochloride629.6ADRA2C, ADRA2B
9jp 1302 dihydrochloride629.6ADRA2C, ADRA2B
10medetomidine hydrochloride629.6ADRA2C, ADRA2B
11(plusmn)-adrenaline309.6ADRA2B, ADRA2C
12[3h]rauwolscine309.6ADRA2B, ADRA2C
13xylazine46 3010.6ADRA2B, ADRA2C
14tizanidine46 1210.5ADRA2C, ADRA2B
15guanfacine30 46 1211.5ADRA2B, ADRA2C
16wb 4101309.5ADRA2B, ADRA2C
17rauwolscine309.5ADRA2C, ADRA2B
18(-)-noradrenaline309.5ADRA2C, ADRA2B
19spiroxatrine46 3010.5ADRA2B, ADRA2C
20dexmedetomidine46 52 30 1212.5ADRA2C, ADRA2B
21fenoldopam46 1210.5ADRA2C, ADRA2B
22oxymetazoline46 30 1211.5ADRA2C, ADRA2B
23brimonidine46 30 1211.5ADRA2B, ADRA2C
24phenoxybenzamine46 1210.5ADRA2C, ADRA2B
25roxindole30 4610.5ADRA2C, ADRA2B
26terguride46 3010.5ADRA2B, ADRA2C
27phentolamine46 30 1211.5ADRA2C, ADRA2B
28ropinirole46 1210.5ADRA2C, ADRA2B
29lisuride46 30 1211.5ADRA2B, ADRA2C
30pergolide46 30 1211.5ADRA2C, ADRA2B
31paliperidone46 1210.5ADRA2C, ADRA2B
32pramipexole46 30 52 1212.5ADRA2B, ADRA2C
33asenapine30 1210.5ADRA2C, ADRA2B
34cabergoline46 30 1211.4ADRA2C, ADRA2B
35doxepin46 30 52 1212.4ADRA2B, ADRA2C
36prazosin46 30 52 1212.4ADRA2C, ADRA2B
37aripiprazole30 46 52 25 1213.4ADRA2C, ADRA2B
38ziprasidone30 52 46 1212.4ADRA2C, ADRA2B
39yohimbine46 3 30 1212.4ADRA2C, ADRA2B
40apomorphine30 46 1211.4ADRA2C, ADRA2B
41quetiapine46 52 30 25 1213.3ADRA2B, ADRA2C
42bromocriptine46 30 1211.3ADRA2C, ADRA2B
43chlorpromazine30 46 52 1212.3ADRA2C, ADRA2B
44methamphetamine46 52 1211.2ADRA2B, ADRA2C
45risperidone46 52 30 62 25 1214.2ADRA2C, ADRA2B
46clonidine46 52 30 1212.1ADRA2C, ADRA2B
47olanzapine46 52 30 25 1213.0ADRA2B, ADRA2C
48norepinephrine46 25 1210.9SPR, ADRA2B, ADRA2C
49clozapine46 30 52 1211.8ADRA2C, ADRA2B
50glutamate468.7ASPA, ADRA2B, MPZ

GO Terms for genes affiliated with Neurologic Diseases

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17Gene Ontology
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Biological processes related to Neurologic Diseases according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPK activity by adrenergic receptor signaling pathwayGO:0718839.3ADRA2C, ADRA2B
2epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:0356259.2ADRA2C, ADRA2B
3negative regulation of epinephrine secretionGO:0328119.2ADRA2C, ADRA2B
4negative regulation of norepinephrine secretionGO:0107009.1ADRA2B, ADRA2C
5female pregnancyGO:0075659.1ADRA2C, ADRA2B
6activation of protein kinase B activityGO:0321489.0ADRA2C, ADRA2B
7positive regulation of neuron differentiationGO:0456668.8ADRA2C, ADRA2B

Molecular functions related to Neurologic Diseases according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:0513799.1ADRA2C, ADRA2B
2alpha2-adrenergic receptor activityGO:0049388.8ADRA2C, ADRA2B

Products for genes affiliated with Neurologic Diseases

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Sources for Neurologic Diseases

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet