MCID: NRM004
MIFTS: 48

Neuroma malady

Summaries for Neuroma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A neuroma /njuːˈroʊmə/ (plural: neuromata) is a growth or tumor of nerve tissue. Neuromas tend to be... more...

MalaCards: Neuroma, also known as neuroma nos, is related to acoustic neuroma and multiple endocrine neoplasia. An important gene associated with Neuroma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are DNA Damage Recognition in GG-NER and Base-Excision Repair, AP Site Formation. The compounds phosphodiester and polynucleotide have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and integument.

Aliases & Classifications for Neuroma

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

neuroma 8 45 61
neuroma nos 8


External Ids:

Disease Ontology8 DOID:2001
MeSH35 D009463
NCIt40 C3275

Related Diseases for Neuroma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neuroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1acoustic neuroma31.8NF2, ABCA2, GDNF, VHL
2multiple endocrine neoplasia30.6GDNF, VHL, NF2
3neurofibromatosis30.5VHL, NF2, GDNF
4thyroid medullary carcinoma30.0GDNF, VHL, SSTR1
5n syndrome10.6
6multiple mucosal neuroma10.4
7cerebrospinal fluid leak10.4
8headache10.4
9wagenmann-froboese syndrome10.2
10sensorineural hearing loss10.1
11plexiform neurofibroma10.1
12brain cancer10.1
13pheochromocytoma10.1
14ramsay-hunt syndrome10.1
15otosclerosis10.0
16neuroma biliary tract10.0
17meningioma10.0NF2
18pancreatic cancer10.0GDNF, SSTR1, LIG1
19lynch syndrome10.0MUTYH
20ovarian cancer10.0NF2, RAD52
21skin cancer10.0XRCC3, XPC
22schimke immunoosseous dysplasia10.0LIG4, LIG1
23leukemia10.0CRLF1, GDNF, POLB, LIG4
24microcephaly10.0LIG4
25ataxia telangiectasia10.0LIG4, LIG1, XRCC3
26adenoma10.0XRCC3, SSTR1, MUTYH, GDNF, VHL
27nijmegen breakage syndrome10.0LIG1, LIG4
28bloom syndrome10.0LIG1
29hepatocellular carcinoma10.0XPC, MUTYH
30photosensitive trichothiodystrophy10.0ERCC5, ERCC4, XPC
31adenocarcinoma10.0ERCC4, NF2, SSTR1, XPC, XRCC3, VHL
32cockayne syndrome10.0XPC, RAD23B, ERCC4, ERCC5
33colorectal cancer10.0XRCC3, XPC, NF2, POLB, MUTYH
34astrocytoma10.0NF2, GDNF, XPC, VHL
35werner syndrome10.0POLB
36neurilemmoma10.0NF2
37prostate cancer10.0LIG4, XRCC3, XPC, SSTR1, NF2, ERCC4
38melanoma10.0XPC, POLB, GDNF, ERCC5, NF2, XRCC3
39xeroderma pigmentosum10.0ERCC4, XRCC3, ERCC5, RAD23B, LIG1, LIG4
40bladder carcinoma10.0XRCC3, XPC, POLB, ERCC4
41multiple endocrine neoplasia type 2a10.0VHL, GDNF
42stomach cancer10.0XRCC3, VHL, MUTYH, POLB
43malignant glioma10.0VHL, POLB, NF2, XRCC3, GDNF
44lung cancer10.0XRCC3, LIG1, SSTR1, LIG4, MUTYH, ERCC4
45facial paralysis10.0NF2, FKBP4
46breast cancer10.0XRCC3, ERCC4, NF2, RAD52, FKBP4, POLB
47glioblastoma multiforme10.0VHL, GDNF
48fanconi's anemia10.0LIG4, ERCC4
49squamous cell carcinoma10.0VHL, XPC, SSTR1, XRCC3, ERCC4
50breast reconstruction9.9

Graphical network of the top 20 diseases related to Neuroma:



Diseases related to neuroma

Clinical Features for Neuroma

Drugs & Therapeutics for Neuroma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Neuroma

Search CenterWatch for Neuroma

Genetic Tests for Neuroma

Anatomical Context for Neuroma

Animal Models for Neuroma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Neuroma

Sources:
51PubMed
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Articles related to Neuroma:

(show top 50)    (show all 876)
idTitleAuthorsYear
1
Simple electrodiagnostic method for morton neuroma. (23649839)
2014
2
Ultrasonographic Findings of Neuroma Formation at Both Divisions of the Sciatic Nerve in a Transfemoral Amputee. (23552329)
2013
3
Chorda tympani neuroma. (23540565)
2013
4
Treatment of morton neuroma with botulinum toxin A: a pilot study. (23740337)
2013
5
Factors associated with symptom-specific psychological and functional impact among acoustic neuroma patients. (24351880)
2013
6
Intraosseous traumatic neuroma of the lumbar spine: a previously unrecognized form of vertebral pseudotumor. (23211435)
2013
7
Hearing preservation surgery in acoustic neuroma: long-term results. (22767970)
2012
8
Multiple mucosal neuromas in the larynx as part of a multiple endocrine neoplasia type 2B. (23218252)
2012
9
Ultrasonographic guidance and characterization of cryoanalgesic lesions in treating a case of refractory sural neuroma. (22606391)
2011
10
The origin of traumatic neuroma development. (20970962)
2011
11
Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain. (21907491)
2011
12
Morton neuroma: MR imaging after resection--postoperative MR and histologic findings in asymptomatic and symptomatic intermetatarsal spaces. (20501722)
2010
13
Insufficient pain relief after surgical neuroma treatment: Prognostic factors and central sensitisation. (19559663)
2010
14
Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain. (21138586)
2010
15
Ultrasound demonstration of vascularity changes with changes in pain perception in a stump neuroma. (19333177)
2009
16
Heel neuroma: a case study. (19423042)
2009
17
Conductive hearing loss after removal of acoustic neuroma. (18451754)
2008
18
Hearing preservation using combined monitoring of extra-tympanic electrocochleography and auditory brainstem responses during acoustic neuroma surgery. (18389413)
2008
19
Navigating change and the acoustic neuroma story: methods, outcomes, and myths. (19248668)
2008
20
Brachial plexus neuroma mimicking local recurrence of malignant mesenchymal tumor after forequarter amputation. (19292195)
2008
21
Practical experience with sonographically guided phenol instillation of stump neuroma: predictors of effects, success, and outcome. (18430842)
2008
22
Hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma surgery-update. (17414174)
2007
23
T1-nerve root neuroma presenting with apical mass and Horner's syndrome. (17371587)
2007
24
Traumatic neuroma: a late complication of otoplasty. (17362823)
2007
25
Endoscopic assisted microneurosurgery for gasserian portion of trigeminal neuroma: two cases. (17119812)
2006
26
Exposure to loud noise and risk of acoustic neuroma. (17008419)
2006
27
Case-control study on cellular and cordless telephones and the risk for acoustic neuroma or meningioma in patients diagnosed 2000-2003. (15956809)
2005
28
Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm. (15744156)
2005
29
Facial paralysis and surgical rehabilitation: a quality of life analysis in a cohort of 1,595 patients after acoustic neuroma surgery. (15891659)
2005
30
A case of medullomyoblastoma of cerebellopontine angle mimicking acoustic neuroma. (15344215)
2004
31
What you need to know about acoustic neuroma. (15500233)
2004
32
The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas. (14747443)
2004
33
Impact of tumor size on hearing outcome and facial function with the middle fossa approach for acoustic neuroma: a meta-analytic study. (12797585)
2003
34
Cerebro-spinal fluid leak after acoustic neuroma surgery. (12806313)
2003
35
Acoustic neuroma presenting as exercise-induced vertigo. (12389693)
2002
36
Acoustic neuroma--surgery or radiosurgery? (11279355)
2000
37
Trigeminal neuralgia due to an acoustic neuroma in the cerebellopontine angle. (11203749)
2000
38
Dynamic assessment of imbalance in acoustic neuroma patients by sway magnetometry (11123176)
2000
39
Acoustic neuroma: deterioration of speech discrimination related to thresholds in pure-tone audiometry. (11039874)
2000
40
Stereocilia-like structures in the endolymphatic sac in MAcniA"re's disease and acoustic neuroma. (9892873)
1999
41
Is there still a role for auditory brainstem response audiometry in the diagnosis of acoustic neuroma? (10037293)
1999
42
Decompression of the labyrinthine segment of the facial nerve in acoustic neuroma surgery: a consideration for minimizing postoperative delayed facial nerve dysfunction. (17112222)
1998
43
Facial nerve injury in acoustic neuroma (vestibular schwannoma) surgery: etiology and prevention. (9202266)
1997
44
Electrically evoked auditory brainstem response by direct electrical stimulation to the cochlear nerve in acoustic neuroma patients. (9166874)
1997
45
A critical appraisal of the role of auditory brain stem response and magnetic resonance imaging in acoustic neuroma diagnosis. (9303169)
1997
46
Tinnitus and translabyrinthine acoustic neuroma surgery. (9390844)
1997
47
Exophytic pontine glioblastoma mimicking acoustic neuroma. (9555650)
1997
48
Brain stem implantable electrodes in management of total deafness after removal of acoustic neuroma--a review of operative approaches. (9243941)
1996
49
Continuous retrograde monitoring of the facial nerve: preliminary experience during acoustic neuroma surgery. (17170981)
1996
50
Acoustic neuroma update. (8743338)
1996

Genetic Variations for Neuroma

Expression for genes affiliated with Neuroma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroma

Search GEO for disease gene expression data for Neuroma.

Pathways for genes affiliated with Neuroma

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Neuroma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 29IUPHAR, 2BitterDB
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Compounds related to Neuroma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1phosphodiester4510.6POLB, ERCC5, LIG1
2polynucleotide4510.6LIG4, LIG1, POLB
38-oxo-dg4510.6LIG1, POLB, MUTYH
4mitomycin c4510.5XRCC3, XRCC2, POLB, ERCC4
58-oxo-dgtp45 2411.5MUTYH, POLB
6l1896010.5LIG1, LIG4
7oligonucleotide4510.4VHL, ERCC5, GDNF, POLB, LIG1, XPC
8melphalan45 1111.4ERCC4, POLB, XRCC3
9cisplatin45 50 60 1113.4XRCC3, XRCC2, XPC, LIG1, POLB, RAD52
10thymine glycol4510.4POLB, ERCC5
118-oxoguanine4510.4MUTYH, POLB
12atp45 2911.4POLB, FKBP4, GDNF, ABCA2, ERCC5, XPC
13caffeine45 50 29 2 11 2415.3LIG1, XRCC2, XRCC3
14camptothecin45 60 1112.1XRCC3, XRCC2, RAD52

GO Terms for genes affiliated with Neuroma

Sources:
16Gene Ontology
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Cellular components related to Neuroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1XPC complexGO:07194210.4RAD23B, XPC
2nucleoplasmGO:0056549.9MUTYH, ERCC4, RAD52, RAD23B, POLB, LIG1
3nucleusGO:0056349.5VHL, ERCC5, XRCC3, XRCC2, XPC, ERCC4

Biological processes related to Neuroma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1nucleotide-excision repair, DNA damage recognitionGO:00071510.7RAD23B, XPC
2nucleotide-excision repair, DNA gap fillingGO:00629710.7POLB, LIG4, LIG1
3negative regulation of neuron apoptotic processGO:04352410.6LIG4, GDNF, CRLF1, XRCC2
4lagging strand elongationGO:00627310.6LIG4, LIG1
5nucleotide-excision repair, DNA incision, 3-to lesionGO:00629510.6ERCC4, ERCC5
6nucleotide-excision repair, DNA damage removalGO:00071810.6ERCC5, ERCC4, RAD23B, XPC
7double-strand break repair via homologous recombinationGO:00072410.6XRCC2, ERCC4, RAD52, LIG1
8base-excision repairGO:00628410.6LIG1, MUTYH, POLB
9nucleotide-excision repairGO:00628910.6ERCC5, ERCC4, XPC, RAD23B, LIG1
10DNA ligation involved in DNA repairGO:05110310.5LIG1, LIG4
11transcription-coupled nucleotide-excision repairGO:00628310.5ERCC4, ERCC5, LIG1
12telomere maintenanceGO:00072310.5LIG1, ERCC4, RTEL1
13V(D)J recombinationGO:03315110.5LIG1, LIG4
14double-strand break repairGO:00630210.5LIG4, LIG1, RAD52
15positive regulation of neurogenesisGO:05076910.4LIG4, XRCC2
16UV protectionGO:00965010.4ERCC4, ERCC5
17double-strand break repair via nonhomologous end joiningGO:00630310.3LIG4, LIG1
18DNA repairGO:00628110.3RAD23B, ERCC4, RTEL1, RAD52, MUTYH, POLB
19response to X-rayGO:01016510.1XRCC2, LIG4

Molecular functions related to Neuroma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1DNA ligase activityGO:00390910.5LIG4, LIG1
2damaged DNA bindingGO:00368410.5XPC, RAD23B, ERCC4, POLB
3DNA ligase (ATP) activityGO:00391010.5LIG4, LIG1
4single-stranded DNA bindingGO:00369710.5ERCC5, XPC, RAD23B, ERCC4
5bubble DNA bindingGO:00040510.5ERCC5, XPC
6endodeoxyribonuclease activityGO:00452010.4ERCC5, ERCC4
7metal ion bindingGO:04687210.2LIG1, POLB, MUTYH, RTEL1, ZNF350, ERCC5
8ATP bindingGO:00552410.1XRCC3, XRCC2, LIG1, FKBP4, ABCA2, RTEL1
9protein bindingGO:00551510.1MUTYH, FKBP4, ERCC5, RAD23B, POLB, ERCC4
10DNA bindingGO:0036779.9ZNF350, LIG4, XRCC3, XRCC2, LIG1, RAD52

Products for genes affiliated with Neuroma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neuroma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet