MCID: NRM004
MIFTS: 55

Neuroma malady

Neuronal diseases category

Summaries for Neuroma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A neuroma /njuːˈroʊmə/ (plural: neuromata or neuromas) is a growth or tumor of nerve tissue.... more...

MalaCards: Neuroma, also known as neuroma nos, is related to acoustic neuroma and neurofibromatosis. An important gene associated with Neuroma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are DNA Damage Recognition in GG-NER and Base-Excision Repair, AP Site Formation. The compounds phosphodiester and polynucleotide have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and breast, and related mouse phenotypes are tumorigenesis and integument.

Aliases & Classifications for Neuroma

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroma 8 44 60
neuroma nos 8


External Ids:

Disease Ontology8 DOID:2001
MeSH34 D009463
NCIt39 C3275

Related Diseases for Neuroma

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17GeneCards, 18GeneDecks
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Diseases related to Neuroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1acoustic neuroma31.8ABCA2, GDNF, NF2, VHL
2neurofibromatosis30.4VHL, NF2, GDNF
3meningioma30.4NF2
4facial paralysis30.3FKBP4, NF2
5thyroid medullary carcinoma30.0VHL, SSTR1, GDNF
6glioblastoma multiforme30.0GDNF, VHL
7neurilemmoma29.7NF2
8lung cancer29.7VHL, XRCC3, XPC, LIG4, LIG1, SSTR1
9breast cancer29.7XRCC3, XRCC2, XPC, LIG4, SSTR1, NF2
10multiple mucosal neuroma10.4
11cervicitis10.2
12meningitis10.2
13wagenmann-froboese syndrome10.1
14hydrocephalus10.1
15laryngitis10.1
16neurofibroma10.1
17sensorineural hearing loss10.1
18arachnoiditis10.1
19brain cancer10.1
20pheochromocytoma10.1
21burns10.0
22breast reconstruction10.0
23otosclerosis10.0
24plexiform neurofibroma10.0
25geniculate ganglionitis10.0
26hemangioma10.0
27herpes simplex10.0
28intestinal obstruction10.0
29pancreatitis10.0
30sarcoma10.0
31thyroiditis10.0
32neuroma biliary tract10.0
33pancreatic cancer10.0LIG1, SSTR1, GDNF
34lynch syndrome10.0MUTYH
35ovarian cancer10.0RAD52, NF2
36schimke immunoosseous dysplasia10.0LIG1, LIG4
37leukemia10.0CRLF1, LIG4, POLB, GDNF
38microcephaly10.0LIG4
39ataxia telangiectasia10.0XRCC3, LIG4, LIG1
40adenoma10.0VHL, XRCC3, SSTR1, MUTYH, GDNF
41nijmegen breakage syndrome10.0LIG1, LIG4
42bloom syndrome10.0LIG1
43hepatocellular carcinoma10.0MUTYH, XPC
44photosensitive trichothiodystrophy10.0ERCC5, ERCC4, XPC
45adenocarcinoma10.0VHL, XRCC3, XPC, SSTR1, NF2, ERCC4
46cockayne syndrome10.0XPC, RAD23B, ERCC4, ERCC5
47colorectal cancer10.0MUTYH, POLB, NF2, XPC, XRCC3
48astrocytoma10.0VHL, XPC, NF2, GDNF
49werner syndrome10.0POLB
50prostate cancer10.0XRCC3, XPC, LIG4, SSTR1, NF2, ERCC4

Graphical network of the top 20 diseases related to Neuroma:



Diseases related to neuroma

Clinical Features for Neuroma

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Drugs & Therapeutics for Neuroma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Neuroma

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Genetic Tests for Neuroma

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Anatomical Context for Neuroma

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32MalaCards
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MalaCards organs/tissues related to Neuroma:

32
Bone, Brain, Breast, Testes, Skin, Tongue, Thyroid, Appendix, B cells, Temporal lobe, Eye, Lung, Liver, Colon, Spinal cord, Pituitary

Animal Models for Neuroma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuroma:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.6NF2, LIG1, VHL
2MP:001077110.5XRCC2, XPC, LIG1, POLB
3MP:000537010.4VHL, LIG4, LIG1, NF2, POLB, ERCC4
4MP:000363110.4CRLF1, LIG4, SSTR1, NF2, MUTYH, GDNF
5MP:000538910.3VHL, LIG4, NF2, GDNF, ABCA2, RAD23B
6MP:000538010.3VHL, XRCC2, LIG1, NF2, POLB, FKBP4
7MP:000538110.2LIG4, FKBP4, GDNF, RAD23B, ERCC5, VHL
8MP:000538410.2VHL, XRCC2, XPC, LIG4, LIG1, SSTR1
9MP:000537810.1NF2, LIG1, LIG4, XPC, XRCC2, VHL
10MP:000538610.1XPC, CRLF1, LIG4, SSTR1, NF2, POLB
11MP:000537610.1SSTR1, LIG1, LIG4, XPC, XRCC2, VHL
12MP:001076810.1ERCC5, VHL, XRCC2, XPC, CRLF1, LIG4
13MP:000538710.0VHL, LIG4, LIG1, NF2, POLB, GDNF
14MP:00053979.9VHL, CRLF1, LIG4, LIG1, POLB, GDNF

Publications for Neuroma

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50PubMed
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Articles related to Neuroma:

(show top 50)    (show all 841)
idTitleAuthorsYear
1
A case of gastric cancer manifesting as a solitary brain metastasis in the cerebellopontine angle that mimicked acoustic neuroma. (24400217)
2013
2
The safe zone of posterior semicircular canal resection in suboccipital retrosigmoid sinus approach for acoustic neuroma surgery. (24220416)
2013
3
Successful delayed reconstruction of common peroneal neuroma-in-continuity using sural nerve graft. (23180561)
2013
4
A pain model with a neuropathic somatosensory lesion: Morton neuroma. (23886521)
2013
5
Authors' response to: The case of acoustic neuroma: comment on mobile phone use and risk of brain neoplasms and other cancers. (24078152)
2013
6
Morton's neuroma: A clinical versus radiological diagnosis. (22325999)
2012
7
Therapeutic Massage Provides Pain Relief to a Client with Morton's Neuroma: A Case Report. (22811757)
2012
8
Reduction of post-traumatic neuroma and epineural scar formation in rat sciatic nerve by application of microcrystallic chitosan. (22009638)
2011
9
A case of scar sarcoidosis presenting with a nodular mass infiltrating a neuroma in the hand. (21169303)
2011
10
Morton's neuroma. (20934103)
2010
11
Insufficient pain relief after surgical neuroma treatment: Prognostic factors and central sensitisation. (19559663)
2010
12
Traumatic neuroma of the infrapatellar branch of the saphenous nerve after hamstring harvesting. (21446630)
2010
13
Neuroma of a double gallbladder: a case report. (19126190)
2009
14
Ultrasound demonstration of vascularity changes with changes in pain perception in a stump neuroma. (19333177)
2009
15
Cold intolerance in surgically treated neuroma patients: a prospective follow-up study. (19766409)
2009
16
Microsurgical anatomy of acoustic neuroma. 2002. (18534333)
2008
17
Traumatic neuroma of the lower lip with intraepithelial nerve fibers. (18251748)
2008
18
Plantar versus dorsal incision in the treatment of primary intermetatarsal Morton's neuroma. (18315967)
2008
19
Comparison of sensorimotor disturbance between subjects with persistent whiplash-associated disorder and subjects with vestibular pathology associated with acoustic neuroma. (18295632)
2008
20
Human neuroma contains increased levels of semaphorin 3A, which surrounds nerve fibers and reduces neurite extension in vitro. (18160633)
2007
21
Symptoms of acute appendicitis caused by primary neuroma of the appendix. (17879700)
2007
22
Modified dynamic visual acuity tests after acoustic neuroma resection. (17762992)
2007
23
Occupational noise exposure and risk of acoustic neuroma. (17804860)
2007
24
Conservative management of acoustic neuroma. (17077873)
2006
25
Increased calcitonin gene-related peptide in neuroma and invading macrophages is involved in the up-regulation of interleukin-6 and thermal hyperalgesia in a rat model of mononeuropathy. (16805807)
2006
26
Prevention and management of painful neuroma. (16498214)
2006
27
Cystic acoustic neuroma. (15851076)
2005
28
Traumatic (or amputation) neuroma. (15315579)
2004
29
Opening cerebrospinal fluid pressure guides the management of cerebrospinal fluid leakage after acoustic neuroma surgery. (15354009)
2004
30
Re: Factors affecting recovery after acoustic neuroma resection by Cohen et al. (14575408)
2003
31
Early rehabilitation of facial nerve deficit after acoustic neuroma surgery. (14606595)
2003
32
Clinical and histopathologic features of recurrent vestibular schwannoma (acoustic neuroma) after stereotactic radiosurgery. (12851560)
2003
33
Hypervascular intracisternal acoustic neuroma. (12297735)
2002
34
Evaluation of three intraoperative auditory monitoring techniques in acoustic neuroma surgery. (10733192)
2000
35
A modified retrosigmoid approach for direct exposure of the fundus of the internal auditory canal for hearing preservation in acoustic neuroma surgery. (10651442)
2000
36
Audiovestibular findings and location of an acoustic neuroma. (10923934)
2000
37
Audiovestibular findings prior to and after acoustic neuroma surgery. (14689622)
2000
38
Tumor-associated hemorrhage in patients with acoustic neuroma. (10993463)
2000
39
Impairments, disabilities, and handicaps after acoustic neuroma surgery. (10764238)
2000
40
Failed stereotactic radiosurgery for acoustic neuroma. (18639133)
1999
41
A rare case of acoustic neuroma extending from the cerebellopontine angle to the external auditory canal. (18644299)
1998
42
Operating on intracanalicular acoustic neuroma--what would ENT doctors choose for themselves? (9593417)
1998
43
MRI screening for acoustic neuroma without gadolinium: value of 3DFT-CISS sequence. (9272499)
1997
44
Evolution of the management of hydrocephalus associated with acoustic neuroma. (8583854)
1996
45
A case of traumatic neuroma of the gallbladder in the absence of previous surgery and cholelithiasis. (8914682)
1996
46
Acoustic neuroma may impair vision. (8597707)
1996
47
Delayed facial palsy after acoustic neuroma resection: the role of viral reactivation. (8841711)
1996
48
Clear cell sarcoma presenting as an interdigital neuroma. (1523011)
1992
49
Neurilemmoma of the ninth cranial nerve masquerading as an acoustic neuroma. (4842614)
1974
50
Fluorescence microscopy and fluorescence microphotography of neuroma, myoma and fibroma of the digestive tract]. (13407471)
1956

Genetic Variations for Neuroma

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Expression for genes affiliated with Neuroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroma

Search GEO for disease gene expression data for Neuroma.

Pathways for genes affiliated with Neuroma

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Neuroma

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44Novoseek, 59Tocris Bioscience, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Neuroma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1phosphodiester4410.6ERCC5, POLB, LIG1
2polynucleotide4410.6LIG4, LIG1, POLB
38-oxo-dg4410.6LIG1, POLB, MUTYH
4l1895910.5LIG1, LIG4
5mitomycin c4410.5XRCC3, XRCC2, POLB, ERCC4
68-oxo-dgtp44 2411.5MUTYH, POLB
7oligonucleotide4410.4VHL, XPC, LIG1, POLB, GDNF, ERCC5
8melphalan44 1111.4XRCC3, POLB, ERCC4
9cisplatin44 49 59 1113.4ERCC5, XRCC3, XRCC2, XPC, LIG1, POLB
10thymine glycol4410.4ERCC5, POLB
118-oxoguanine4410.4MUTYH, POLB
12atp44 2811.4XPC, LIG1, POLB, FKBP4, GDNF, ABCA2
13caffeine44 49 28 2 11 2415.3XRCC3, XRCC2, LIG1
14camptothecin44 59 1112.1RAD52, XRCC2, XRCC3

GO Terms for genes affiliated with Neuroma

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16Gene Ontology
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Cellular components related to Neuroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1XPC complexGO:07194210.4RAD23B, XPC
2nucleoplasmGO:0056549.9ERCC5, VHL, XPC, LIG4, LIG1, POLB
3nucleusGO:0056349.5NF2, LIG1, LIG4, XPC, XRCC2, XRCC3

Biological processes related to Neuroma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1nucleotide-excision repair, DNA damage recognitionGO:00071510.7RAD23B, XPC
2nucleotide-excision repair, DNA gap fillingGO:00629710.7POLB, LIG1, LIG4
3negative regulation of neuron apoptotic processGO:04352410.6XRCC2, CRLF1, LIG4, GDNF
4lagging strand elongationGO:00627310.6LIG1, LIG4
5nucleotide-excision repair, DNA incision, 3-to lesionGO:00629510.6ERCC4, ERCC5
6nucleotide-excision repair, DNA damage removalGO:00071810.6ERCC5, ERCC4, RAD23B, XPC
7double-strand break repair via homologous recombinationGO:00072410.6XRCC2, LIG1, RAD52, ERCC4
8base-excision repairGO:00628410.6MUTYH, POLB, LIG1
9nucleotide-excision repairGO:00628910.6XPC, LIG1, RAD23B, ERCC4, ERCC5
10DNA ligation involved in DNA repairGO:05110310.5LIG1, LIG4
11transcription-coupled nucleotide-excision repairGO:00628310.5ERCC5, ERCC4, LIG1
12telomere maintenanceGO:00072310.5LIG1, RTEL1, ERCC4
13V(D)J recombinationGO:03315110.5LIG1, LIG4
14double-strand break repairGO:00630210.5RAD52, LIG1, LIG4
15positive regulation of neurogenesisGO:05076910.4LIG4, XRCC2
16UV protectionGO:00965010.4ERCC4, ERCC5
17double-strand break repair via nonhomologous end joiningGO:00630310.3LIG1, LIG4
18DNA repairGO:00628110.3ERCC5, XRCC3, XRCC2, XPC, LIG4, LIG1
19response to X-rayGO:01016510.1LIG4, XRCC2

Molecular functions related to Neuroma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1DNA ligase (ATP) activityGO:00391010.5LIG4, LIG1
2damaged DNA bindingGO:00368410.5ERCC4, RAD23B, POLB, XPC
3DNA ligase activityGO:00390910.5LIG4, LIG1
4single-stranded DNA bindingGO:00369710.5ERCC5, ERCC4, RAD23B, XPC
5bubble DNA bindingGO:00040510.5ERCC5, XPC
6endodeoxyribonuclease activityGO:00452010.4ERCC5, ERCC4
7metal ion bindingGO:04687210.2LIG1, POLB, MUTYH, RTEL1, ZNF350, ERCC5
8ATP bindingGO:00552410.1XRCC3, XRCC2, LIG4, LIG1, FKBP4, ABCA2
9protein bindingGO:00551510.1LIG4, CRLF1, XPC, XRCC2, XRCC3, VHL
10DNA bindingGO:0036779.9XRCC3, XRCC2, LIG4, LIG1, RAD52, RTEL1

Products for genes affiliated with Neuroma

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Sources for Neuroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet