MCID: NRM004
MIFTS: 55

Neuroma malady

Neuronal diseases category

Summaries for Neuroma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A neuroma /njuːˈroʊmə/ (plural: neuromata or neuromas) is a growth or tumor of nerve tissue.... more...

MalaCards: Neuroma, also known as neuroma nos, is related to acoustic neuroma and neurofibromatosis. An important gene associated with Neuroma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are DNA Damage Recognition in GG-NER and Base-Excision Repair, AP Site Formation. The compounds phosphodiester and polynucleotide have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and breast, and related mouse phenotypes are tumorigenesis and integument.

Aliases & Classifications for Neuroma

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroma 8 44 60
neuroma nos 8


External Ids:

Disease Ontology8 DOID:2001
MeSH34 D009463
NCIt39 C3275

Related Diseases for Neuroma

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17GeneCards, 18GeneDecks
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Diseases related to Neuroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1acoustic neuroma31.8ABCA2, GDNF, NF2, VHL
2neurofibromatosis30.4VHL, NF2, GDNF
3meningioma30.4NF2
4facial paralysis30.3FKBP4, NF2
5thyroid medullary carcinoma30.0VHL, SSTR1, GDNF
6glioblastoma multiforme30.0GDNF, VHL
7neurilemmoma29.7NF2
8lung cancer29.7VHL, XRCC3, XPC, LIG4, LIG1, SSTR1
9breast cancer29.7XRCC3, XRCC2, XPC, LIG4, SSTR1, NF2
10multiple mucosal neuroma10.4
11cervicitis10.2
12meningitis10.2
13wagenmann-froboese syndrome10.1
14hydrocephalus10.1
15laryngitis10.1
16neurofibroma10.1
17sensorineural hearing loss10.1
18arachnoiditis10.1
19brain cancer10.1
20pheochromocytoma10.1
21burns10.0
22breast reconstruction10.0
23otosclerosis10.0
24plexiform neurofibroma10.0
25geniculate ganglionitis10.0
26hemangioma10.0
27herpes simplex10.0
28intestinal obstruction10.0
29pancreatitis10.0
30sarcoma10.0
31thyroiditis10.0
32neuroma biliary tract10.0
33pancreatic cancer10.0LIG1, SSTR1, GDNF
34lynch syndrome10.0MUTYH
35ovarian cancer10.0RAD52, NF2
36schimke immunoosseous dysplasia10.0LIG1, LIG4
37leukemia10.0CRLF1, LIG4, POLB, GDNF
38microcephaly10.0LIG4
39ataxia telangiectasia10.0XRCC3, LIG4, LIG1
40adenoma10.0VHL, XRCC3, SSTR1, MUTYH, GDNF
41nijmegen breakage syndrome10.0LIG1, LIG4
42bloom syndrome10.0LIG1
43hepatocellular carcinoma10.0MUTYH, XPC
44photosensitive trichothiodystrophy10.0ERCC5, ERCC4, XPC
45adenocarcinoma10.0VHL, XRCC3, XPC, SSTR1, NF2, ERCC4
46cockayne syndrome10.0XPC, RAD23B, ERCC4, ERCC5
47colorectal cancer10.0MUTYH, POLB, NF2, XPC, XRCC3
48astrocytoma10.0VHL, XPC, NF2, GDNF
49werner syndrome10.0POLB
50prostate cancer10.0XRCC3, XPC, LIG4, SSTR1, NF2, ERCC4

Graphical network of the top 20 diseases related to Neuroma:



Diseases related to neuroma

Clinical Features for Neuroma

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Drugs & Therapeutics for Neuroma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Neuroma

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Genetic Tests for Neuroma

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Anatomical Context for Neuroma

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32MalaCards
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MalaCards organs/tissues related to Neuroma:

32
Bone, Brain, Breast, Testes, Skin, Tongue, Thyroid, Appendix, B cells, Temporal lobe, Eye, Lung, Liver, Colon, Spinal cord, Pituitary

Animal Models for Neuroma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuroma:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.6NF2, LIG1, VHL
2MP:001077110.5XRCC2, XPC, LIG1, POLB
3MP:000537010.4VHL, LIG4, LIG1, NF2, POLB, ERCC4
4MP:000363110.4CRLF1, LIG4, SSTR1, NF2, MUTYH, GDNF
5MP:000538910.3VHL, LIG4, NF2, GDNF, ABCA2, RAD23B
6MP:000538010.3VHL, XRCC2, LIG1, NF2, POLB, FKBP4
7MP:000538110.2LIG4, FKBP4, GDNF, RAD23B, ERCC5, VHL
8MP:000538410.2VHL, XRCC2, XPC, LIG4, LIG1, SSTR1
9MP:000537810.1NF2, LIG1, LIG4, XPC, XRCC2, VHL
10MP:000538610.1XPC, CRLF1, LIG4, SSTR1, NF2, POLB
11MP:000537610.1SSTR1, LIG1, LIG4, XPC, XRCC2, VHL
12MP:001076810.1ERCC5, VHL, XRCC2, XPC, CRLF1, LIG4
13MP:000538710.0VHL, LIG4, LIG1, NF2, POLB, GDNF
14MP:00053979.9VHL, CRLF1, LIG4, LIG1, POLB, GDNF

Publications for Neuroma

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50PubMed
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Articles related to Neuroma:

(show top 50)    (show all 841)
idTitleAuthorsYear
1
Expression of c-Jun and Sox-2 in human schwannomas and traumatic neuromas. (23362975)
2013
2
The incidence of symptomatic neuroma in amputation and neurorrhaphy patients. (23845907)
2013
3
Ocular vestibular evoked myogenic potentials in patients with acoustic neuroma. (22526579)
2013
4
Recurrent nasopharyngeal carcinoma masquerading as acoustic neuroma. (22434308)
2012
5
Expression of p63 and p73 in acoustic neuroma and its possible clinical relevance. (22000483)
2012
6
A case report of traumatic neuroma of the cervical spinal cord in a dog. (22214863)
2012
7
Acoustic neuroma neurophysiologic correlates: facial and recurrent laryngeal nerves before, during, and after surgery. (22483817)
2012
8
Efficacy of corticosteroid injection versus size of plantar interdigital neuroma. (22995258)
2012
9
Hearing preservation surgery in acoustic neuroma. Slow progress and new strategies. (22064847)
2011
10
Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma. (20461409)
2010
11
Radio-frequency ablation for the treatment of Morton's neuroma. (20857612)
2010
12
Occupation and risk of glioma, meningioma and acoustic neuroma: results from a German case-control study (interphone study group, Germany). (20061201)
2010
13
Headache syndromes after acoustic neuroma surgery and their implications for quality of life. (19239675)
2009
14
Sonographically guided phenol instillation of stump neuroma. (18941058)
2008
15
Painful, traumatic neuroma of an episiotomy scar: a case report. (17583255)
2007
16
Intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation for preservation of facial nerve function in patients with large acoustic neuroma. (17374285)
2007
17
Comparing size evaluation methods for acoustic neuroma after stereotactic radiosurgery. (17705004)
2007
18
Vestibular schwannoma (acoustic neuroma) mimicking temporomandibular disorders: a case report. (19089251)
2006
19
INTERESTING CASE: acoustic neuroma--an unusual presentation. (16309802)
2006
20
Mucocutaneous neuromas: an underrecognized manifestation of PTEN hamartoma-tumor syndrome. (16702501)
2006
21
Severe vaginal pain caused by a neuroma in the rectovaginal septum after posterior colporrhaphy. (17018512)
2006
22
Pinealectomy exaggerates and melatonin treatment suppresses neuroma formation of transected sciatic nerve in rats: gross morphological, histological and stereological analysis. (15813906)
2005
23
Hearing problems and acoustic neuroma cancer in Sweden. (15996859)
2005
24
Cellular telephone use and risk of acoustic neuroma. (14742288)
2004
25
Facial nerve neuroma: surgical concept and functional results. (16145605)
2004
26
Acoustic neuroma in patients with completely resolved sudden hearing loss. (12784975)
2003
27
Cochlear implantation concurrent with translabyrinthine acoustic neuroma resection. (12616199)
2003
28
Self-assessed quality of life after acoustic neuroma surgery. (14609159)
2003
29
Receptors for NGF and GDNF are highly expressed in human peripheral nerve neuroma. (11932982)
2002
30
Viral titers and delayed facial palsy after acoustic neuroma surgery. (12447236)
2002
31
Navigation-guided opening of the internal auditory canal via the retrosigmoid route for acoustic neuroma surgery: cadaveric, radiological, and preliminary clinical study. (10942011)
2000
32
Acoustic neuroma surgery as an interdisciplinary approach: a neurosurgical series of 508 patients. (10896686)
2000
33
Anxiety, optimism and symptom reporting following surgery for acoustic neuroma. (10193916)
1999
34
Long-term prognosis of profound facial nerve paralysis secondary to acoustic neuroma resection. (10095200)
1999
35
Standardized format for depicting hearing preservation results in the management of acoustic neuroma. (10471853)
1999
36
Adjunctive use of endoscopy during acoustic neuroma surgery. (10443819)
1999
37
An unusual etiology of biliary hilar obstruction and the potential role of acidic fibroblast growth factor in the development of a biliary neuroma. (9915531)
1999
38
Contralateral transient evoked otoacoustic emissions following acoustic neuroma surgery. (9622797)
1998
39
Significance of hearing preservation in acoustic neuroma surgery. (9870643)
1998
40
Temporal bone pathology of acoustic neuroma correlating with presence of electrocochleography and absence of auditory brainstem response. (9425489)
1997
41
Incidence and predictors of bulbar palsy after surgery for acoustic neuroma. (9239590)
1997
42
Hearing preservation surgery in acoustic neuroma patients with normal hearing. (17171019)
1997
43
Residual and recurrent acoustic neuroma in hearing preservation procedures: neuroradiologic and surgical findings. (17170984)
1996
44
Suboccipital surgery for acoustic neuroma. (8818496)
1996
45
A case of delayed loss of facial nerve function after acoustic neuroma surgery. (8794549)
1996
46
Dose and diameter relationships for facial, trigeminal, and acoustic neuropathies following acoustic neuroma radiosurgery. (9027936)
1996
47
Simultaneous presentation of facial nerve neuroma and otosclerosis. (8579155)
1994
48
Immunohistochemical characterization of palisaded, encapsulated neuroma. (1705947)
1990
49
Trigeminal nerve neuroma simulating Tolosa-Hunt syndrome. (7295120)
1981
50
Letter: Multiple mucosal neuroma syndrome. (1147648)
1975

Genetic Variations for Neuroma

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Expression for genes affiliated with Neuroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroma

Search GEO for disease gene expression data for Neuroma.

Pathways for genes affiliated with Neuroma

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Neuroma

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44Novoseek, 59Tocris Bioscience, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Neuroma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1phosphodiester4410.6ERCC5, POLB, LIG1
2polynucleotide4410.6LIG4, LIG1, POLB
38-oxo-dg4410.6LIG1, POLB, MUTYH
4l1895910.5LIG1, LIG4
5mitomycin c4410.5XRCC3, XRCC2, POLB, ERCC4
68-oxo-dgtp44 2411.5MUTYH, POLB
7oligonucleotide4410.4VHL, XPC, LIG1, POLB, GDNF, ERCC5
8melphalan44 1111.4XRCC3, POLB, ERCC4
9cisplatin44 49 59 1113.4ERCC5, XRCC3, XRCC2, XPC, LIG1, POLB
10thymine glycol4410.4ERCC5, POLB
118-oxoguanine4410.4MUTYH, POLB
12atp44 2811.4XPC, LIG1, POLB, FKBP4, GDNF, ABCA2
13caffeine44 49 28 2 11 2415.3XRCC3, XRCC2, LIG1
14camptothecin44 59 1112.1RAD52, XRCC2, XRCC3

GO Terms for genes affiliated with Neuroma

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16Gene Ontology
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Cellular components related to Neuroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1XPC complexGO:07194210.4RAD23B, XPC
2nucleoplasmGO:0056549.9ERCC5, VHL, XPC, LIG4, LIG1, POLB
3nucleusGO:0056349.5NF2, LIG1, LIG4, XPC, XRCC2, XRCC3

Biological processes related to Neuroma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1nucleotide-excision repair, DNA damage recognitionGO:00071510.7RAD23B, XPC
2nucleotide-excision repair, DNA gap fillingGO:00629710.7POLB, LIG1, LIG4
3negative regulation of neuron apoptotic processGO:04352410.6XRCC2, CRLF1, LIG4, GDNF
4lagging strand elongationGO:00627310.6LIG1, LIG4
5nucleotide-excision repair, DNA incision, 3-to lesionGO:00629510.6ERCC4, ERCC5
6nucleotide-excision repair, DNA damage removalGO:00071810.6ERCC5, ERCC4, RAD23B, XPC
7double-strand break repair via homologous recombinationGO:00072410.6XRCC2, LIG1, RAD52, ERCC4
8base-excision repairGO:00628410.6MUTYH, POLB, LIG1
9nucleotide-excision repairGO:00628910.6XPC, LIG1, RAD23B, ERCC4, ERCC5
10DNA ligation involved in DNA repairGO:05110310.5LIG1, LIG4
11transcription-coupled nucleotide-excision repairGO:00628310.5ERCC5, ERCC4, LIG1
12telomere maintenanceGO:00072310.5LIG1, RTEL1, ERCC4
13V(D)J recombinationGO:03315110.5LIG1, LIG4
14double-strand break repairGO:00630210.5RAD52, LIG1, LIG4
15positive regulation of neurogenesisGO:05076910.4LIG4, XRCC2
16UV protectionGO:00965010.4ERCC4, ERCC5
17double-strand break repair via nonhomologous end joiningGO:00630310.3LIG1, LIG4
18DNA repairGO:00628110.3ERCC5, XRCC3, XRCC2, XPC, LIG4, LIG1
19response to X-rayGO:01016510.1LIG4, XRCC2

Molecular functions related to Neuroma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1DNA ligase (ATP) activityGO:00391010.5LIG4, LIG1
2damaged DNA bindingGO:00368410.5ERCC4, RAD23B, POLB, XPC
3DNA ligase activityGO:00390910.5LIG4, LIG1
4single-stranded DNA bindingGO:00369710.5ERCC5, ERCC4, RAD23B, XPC
5bubble DNA bindingGO:00040510.5ERCC5, XPC
6endodeoxyribonuclease activityGO:00452010.4ERCC5, ERCC4
7metal ion bindingGO:04687210.2LIG1, POLB, MUTYH, RTEL1, ZNF350, ERCC5
8ATP bindingGO:00552410.1XRCC3, XRCC2, LIG4, LIG1, FKBP4, ABCA2
9protein bindingGO:00551510.1LIG4, CRLF1, XPC, XRCC2, XRCC3, VHL
10DNA bindingGO:0036779.9XRCC3, XRCC2, LIG4, LIG1, RAD52, RTEL1

Products for genes affiliated with Neuroma

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Sources for Neuroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet