Neuroma malady

Wikipedia: A neuroma (⁴⁴ more...

MalaCards: Neuroma, also known as neuroma nos (morphologic abnormality), is related to acoustic neuroma and neurofibromatosis. An important gene associated with Neuroma is NF2 (neurofibromin 2 (merlin)), and among its related pathways are Dual incision reaction in GG-NER and Homologous recombination. The compounds polynucleotide and 8-oxoguanine have been mentioned in the context of this disorder. Affiliated tissues include b cells and tongue, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Aliases & Descriptions:

neuroma 6 32 43 neuroma nos (morphologic abnormality) 6 neuroma (morphologic abnormality) 6

neuroma (excluding acoustic) 6 neuroma (excl. acoustic) 6

Diseases related to neuroma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 453)

id	Related Disease	Score	Top Affiliating Genes
1	acoustic neuroma	34.8	RDX, VHL, MSN, EZR, ERBB3, NGFR
2	neurofibromatosis	32.1	RDX, MSN, EZR, NF1, NF2, EPOR
3	neurofibroma	28.4	S100B, B2M, CD34, ANK3, MAPK10, SST
4	multiple endocrine neoplasia	28.1	RET, VHL, CALCA, SST, NF1, NF2
5	plexiform neurofibroma	27.7	S100B, B2M, ANK3, NF1, NF2
6	dna ligase iv deficiency	13.8	LIG4, XRCC2, XRCC4
7	photosensitive trichthiodystrophy	13.8	BRIP1, RAD23B, XPC, ERCC2, ERCC5, ERCC4
8	attenuated familial adenomatous polyposis	13.7	MUTYH, MSH2, APEX1, OGG1
9	nijmegen breakage syndrome	13.7	NBN, RAD51, RAD52, LIG4, LIG1
10	arachnoiditis	13.7	SSTR1, CRLF1, NF2, PGR
11	familial medullary thyroid carcinoma	13.7	RET, CALCA, GDNF
12	xeroderma pigmentosum, group d	13.7	XRCC1, XRCC4, XPC, ERCC2
13	bloom syndrome	13.7	BRIP1, RAD51, RAD52, LIG1, XRCC2, ERCC2
14	apudoma	13.7	CALCA, SST, GAST
15	prostate cancer, progression and metastasis of	13.7	RDX, IL6, EZR
16	orofacial cleft	13.6	XRCC1, XRCC3, APEX1, ERCC2, OGG1
17	wdha syndrome	13.6	CALCA, SST, NF1
18	multiple endocrine neoplasia type 2a	13.6	RET, VHL, CALCA, NF1, GDNF
19	meningioma	13.6	PCNA, MKI67, PGR
20	mutagen sensitivity	13.6	PCNA, RAD23B, XRCC1, XRCC3, XPC, ERCC2
21	prostate carcinoma	13.6	NBN, PARP1, ERCC5, ERCC4, OGG1
22	thymic epithelial tumor	13.6	PCNA, MKI67, CALCA, NGFR
23	functioning pituitary adenoma	13.6	PCNA, MKI67, SST, SSTR1
24	somatostatinoma	13.5	CALCA, SST, GAST
25	basal cell carcinoma	13.5	XRCC1, XRCC3, CD34, MKI67, ERCC2
26	amyloid tumor	13.5	B2M, CALCA
27	glucagonoma	13.5	CCK, CALCA, SST, GAST
28	endocrine gland cancer	13.5	RET, SST, GAST
29	achalasia	13.5	RET, PCNA, GAST, GDNF
30	vipoma	13.5	CALCA, SST, GAST
31	tongue cancer	13.5	PCNA, VHL, MKI67, SLC2A1, EPOR
32	skin benign neoplasm	13.5	XPC, MSH2, MGMT, ERCC2, NF1
33	hereditary mucosal leukokeratosis	13.5	PCNA, XRCC1, MKI67, MGMT, ERCC2
34	lynch syndrome	13.5	MSH2, MKI67, MGMT
35	cancer progression/metastasis	13.5	RDX, IL6, EZR, TGFB1
36	pancytopenia	13.5	NBN, LIG4, CD68, MGMT
37	pancreatic islet cell tumors	13.5	RET, CALCA, SST, GAST
38	papillary renal cell carcinoma	13.5	PCNA, VHL, MKI67, OGG1
39	wermer syndrome	13.5	RET, VHL, SST, NF1, GAST
40	benign meningioma	13.5	PCNA, MKI67, NF2, SLC2A1, PGR
41	dyspepsia	13.5	CCK, CALCA, TRPV1, SST, GAST
42	amyloidosis aa	13.4	B2M, IL6
43	bladder cancer susceptibility	13.4	PARP1, MUTYH, XRCC1, XRCC4, APEX1, ERCC2
44	microcephaly	13.4	NBN, LIG4, XRCC4, ERCC2, ERCC5, ERCC4
45	spina bifida	13.4	XRCC1, XRCC3, MGMT, APEX1, ERCC2, OGG1
46	ovarian mucinous neoplasm	13.4	PCNA, MUTYH, MSH2, MKI67, SST
47	female breast cancer	13.4	XRCC1, ERCC2, ERCC5, ERCC4, TGFB1, OGG1
48	familial adenomatous polyposis	13.4	PCNA, VHL, MUTYH, MSH2, MGMT, APEX1
49	ileus	13.4	IL6, CCK, CALCA, SST
50	non-hodgkin lymphoma	13.4	NBN, B2M, MSH2, CD34, ERCC2, NGFR

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to neuroma:

²²

MGI Mouse Phenotypes related to neuroma:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	9.8	TRPV1, NGFR, NF1, NF2, ERCC4, APEX1
2	endocrine/exocrine gland phenotype	MP:0005379	9.7	NF2, NF1, NRG1, AQP1, XRCC4, RAD23B
3	renal/urinary system phenotype	MP:0005367	9.0	POLB, NF2, NF1, NGFR, TRPV1, AQP4
4	respiratory system phenotype	MP:0005388	9.0	POLB, NF2, NF1, TRPA1, CALCA, AQP4
5	reproductive system phenotype	MP:0005389	9.0	IL6, ERCC2, NRG1, NF2, ABCA2, TGFB1
6	embryogenesis phenotype	MP:0005380	9.0	ERBB3, NRG1, NF1, NF2, POLB, RTEL1
7	hearing/vestibular/ear phenotype	MP:0005377	8.8	NF1, NGFR, TRPA1, CALCA, AQP4, AQP1
8	hematopoietic system phenotype	MP:0005397	8.7	CD68, AQP1, ERCC5, CRLF1, NF1, POLB
9	tumorigenesis	MP:0002006	8.2	GAST, MUTYH, LIG1, LIG4, RAD52, VHL
10	digestive/alimentary phenotype	MP:0005381	8.2	ERBB3, ERCC5, SST, NGFR, GFAP, TGFB1
11	no phenotypic analysis	MP:0003012	7.8	TRPV1, SST, SLC2A1, PEX5L, EPOR, AQP4
12	immune system phenotype	MP:0005387	7.8	ERCC2, ERCC5, TRPV1, TRPA1, NF1, NF2
13	vision/eye phenotype	MP:0005391	7.3	NGFR, NF1, NF2, GFAP, TGFB1, GAP43
14	normal phenotype	MP:0002873	7.3	NF1, ELTD1, GFAP, OGG1, RTEL1, PGR
15	cardiovascular system phenotype	MP:0005385	6.4	ERBB3, TRPV1, NRG1, NGFR, NF1, GFAP
16	integument phenotype	MP:0010771	6.0	PGR, POLB, TGFB1, PDE8A, NF1, NGFR
17	mortality/aging	MP:0010768	5.6	EZR, ANK3, APEX1, AQP4, AQP1, IL6
18	cellular phenotype	MP:0005384	5.4	GAP43, EPOR, PGR, RTEL1, SLC2A1, POLB
19	nervous system phenotype	MP:0003631	5.1	GDNF, GAP43, EPOR, PEX5L, RTEL1, SLC2A1
20	growth/size phenotype	MP:0005378	4.8	GDNF, GAP43, RTEL1, SLC2A1, POLB, TGFB1
21	homeostasis/metabolism phenotype	MP:0005376	4.7	PDE8A, FGF1, MGMT, FKBP4, CD34, MSH2
22	behavior/neurological phenotype	MP:0005386	3.6	TRPV1, RET, RDX, NBN, SEMA3A, ERCC2

Articles related to neuroma:

(show all 33)

id	Title	Authors	Year	Affiliating Genes
1	DNA repair gene polymorphisms and risk of adult menin gioma, glioma, and acoustic neuroma. (20150366)	Rajaraman P.... Inskip P.D.	2010	LIG1, RAD51, PARP1
2	Palisaded encapsulated ('solitary circumscribed') neuroma of the oral cavity: a review of 55 cases. (20237984)	Koutlas I.G.... Scheithauer B.W.	2010	GFAP
3	Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and aco ustic neuroma. (20461409)	Ishiyama G.... Ishiyama A.	2010	AQP1, AQP4, AQP6
4	TRPA1 expression in human lingual nerve neuromas in p atients with and without symptoms of dysaesthesia. (19715741)	Morgan C.R.... Boissonade F.M.	2009	TRPA1
5	Mucosal Schwann cell 'hamartoma': clinicopathologic study of 26 neural colorectal polyps distinct from neurofibromas and mucosal neuromas. (19065103)	Gibson J.A.... Hornick J.L.	2009	S100B
6	Immunohistochemical analysis of the purinoceptor P2X7 in human lingual nerve neuromas. (19264037)	Morgan C.R.... Boissonade F.M.	2009	P2RX7
7	GLUT-1 expression confirms the reactive nature of tra umatic neuroma. (19335644)	SedA1 J.	2009	SLC2A1
8	Relevance between clinical behavior and bionomical f indings of acoustic neuromas]. (18510217)	Yang S.M.... Yang W.Y.	2008	TGFB1, PCNA, MKI67
9	Vanilloid receptor 1 (TRPV1) expression in lingual nerve neuromas from patients with or without symptoms of burning pain. (17109831)	Biggs J.E.... Robinson P.P.	2007	TRPV1
10	Human neuroma contains increased levels of semaphorin 3A, which surrounds nerve fibers and reduces neurite extension in vitro. (18160633)	Tannemaat M.R.... Verhaagen J.	2007	SEMA3A, SEMA3F
11	The potential role of nerve growth factor (NGF) in painful neuromas and the mechanism of pain relief by their relocation to muscle. (16928414)	Atherton D.D.... Anand P.	2006	NGF
12	The immunohistochemical localisation of somatostatin receptors 1, 2, 3, and 5 in acoustic neuromas. (14747443)	Stafford N.D.... Atkin S.L.	2004	SSTR1
13	Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain. (15519868)	Kretschmer T.... Kline D.G.	2004	ANK3
14	Association of proliferative activity and size in acoustic neuroma: implications for timing of surgery. (12691406)	Bedavanija A.... Mann W.J.	2003	PCNA
15	Painful neuromas: a potential role for a structural transmembrane protein, ankyrin G. (12507143)	Kretschmer T.... Kline D.G.	2002	ANK3
16	Receptors for NGF and GDNF are highly expressed in human peripheral nerve neuroma. (11932982)	Harpf C.... Humpel C.	2002	GDNF
17	Response of GAP-43 and p75 in human neuromas over time after traumatic injury. (12383368)	Gilmer-Hill H.S.... Kline D.G.	2002	GAP43
18	Accumulation of PN1 and PN3 sodium channels in painful human neuroma-evidence from immunocytochemistry. (12181690)	Kretschmer T.... Kline D.G.	2002	SCN10A
19	Ankyrin G and voltage gated sodium channels colocalize in human neuroma--key proteins of membrane remodeling after axonal injury. (11950515)	Kretschmer T.... Kline D.G.	2002	ANK3
20	Granular cell traumatic neuroma: a lesion occurring in mastectomy scars. (10782152)	Rosso R.... Carnevali L.	2000	CD68
21	Transforming growth factor-beta1 expression in human acoustic neuroma. (9918175)	Cardillo M.R.... Barbara M.	1999	TGFB1, NRG1
22	An unusual etiology of biliary hilar obstruction and the potential role of acidic fibroblast growth factor in the development of a biliary neuroma. (9915531)	Pickens A.... Thompson J.A.	1999	FGF1
23	Neuromas and prominent corneal nerves without MEN 2B. (10189992)	GA^mez J.M.... MartA- T.	1998	RET
24	Peptides and neuromas: calcitonin gene-related peptide, substance P, and mast cells in a mechanosensitive human sural neuroma. (9179160)	Zochodne D.W.... Sutherland G.	1997	CALCA
25	Tumor necrosis factor-alpha and interleukin-1 induce activation of MAP kinase and SAP kinase in human neuroma fibroblasts. (9106254)	Lu G.... Kline D.G.	1997	MAPK10
26	Evidence for CGRP accumulation and activity in experimental neuromas. (7864183)	Zochodne D.W.... Sharkey K.A.	1995	CALCA
27	Relationship of familial prominent corneal nerves and lesions of the tongue resembling neuromas to multiple endocrine neoplasia type 2B. (7573303)	Dennehy P.J.... Jackson C.E.	1995	RET
28	Clinicopathologic growth factors of acoustic neuromas. (7482232)	Kawamoto Y.... Sugiyama K.	1995	PCNA
29	Human acoustic neuromas secrete interleukin-6 in cell culture: possible autocrine regulation of cell proliferation. (7800135)	Adams E.F.... Fahlbusch R.	1994	IL6
30	Molecular genetic analysis of the mechanism of tumorigenesis in acoustic neuroma. (8217082)	Irving R.M.... Maher E.R.	1993	VHL
31	Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse. (1432035)	Lee J.K.... Martuza R.L.	1992	B2M
32	Gastrin, cholecystokinin and their precursors in acoustic neuromas. (1702342)	Rehfeld J.F.... Thomsen J.	1990	SST, CCK, GAST
33	Estrogen and progesterone receptors in acoustic neuromas. (2297415)	Klinken L.... Tos M.	1990	PGR

Genes related to neuroma according to GeneCards:

(show top 50)    (show all 73)

id	Symbol	Description	Score	GeneCards Section Context
1	NF2	neurofibromin 2 (merlin)	11.1	Aliases & Descriptions
2	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Publications
3	GDNF	glial cell derived neurotrophic factor	11.0	Publications
4	RTEL1	regulator of telomere elongation helicase 1	11.0
5	CRLF1	cytokine receptor-like factor 1	11.0
6	SSTR1	somatostatin receptor 1	11.0	Publications
7	ZNF350	zinc finger protein 350	11.0	Publications
8	RAD52	RAD52 homolog (S. cerevisiae)	11.0	Publications
9	ERCC5	excision repair cross-complementing rodent repair deficiency, complementation group 5	11.0	Publications
10	XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2	11.0	Publications
11	LIG4	ligase IV, DNA, ATP-dependent	11.0	Publications
12	ABCA2	ATP-binding cassette, sub-family A (ABC1), member 2	11.0
13	RAD23B	RAD23 homolog B (S. cerevisiae)	11.0	Publications
14	POLB	polymerase (DNA directed), beta	11.0	Publications
15	LIG1	ligase I, DNA, ATP-dependent	11.0	Publications
16	GLTSCR1	glioma tumor suppressor candidate region gene 1	11.0	Publications
17	MUTYH	mutY homolog (E. coli)	11.0	Publications
18	ERCC4	excision repair cross-complementing rodent repair deficiency, complementation group 4	11.0	Publications
19	XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	11.0	Publications
20	XPC	xeroderma pigmentosum, complementation group C	11.0	Publications
21	BRIP1	BRCA1 interacting protein C-terminal helicase 1	11.0	Publications
22	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	11.0	Publications
23	TRPV1	transient receptor potential cation channel, subfamily V, member 1	11.0	Publications
24	RAD51	RAD51 homolog (S. cerevisiae)	11.0	Publications
25	RDX	radixin	11.0
26	OGG1	8-oxoguanine DNA glycosylase	11.0	Publications
27	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	11.0	Publications
28	NBN	nibrin	11.0	Publications
29	NGFR	nerve growth factor receptor	11.0
30	PDE8A	phosphodiesterase 8A	11.0
31	MSN	moesin	11.0
32	CD34	CD34 molecule	11.0
33	ERCC2	excision repair cross-complementing rodent repair deficiency, complementation group 2	11.0	Publications
34	EPOR	erythropoietin receptor	11.0
35	EZR	ezrin	11.0
36	PARP1	poly (ADP-ribose) polymerase 1	11.0	Publications
37	SST	somatostatin	11.0	Publications
38	PCNA	proliferating cell nuclear antigen	11.0	Publications
39	CCK	cholecystokinin	11.0	Publications
40	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	11.0	Publications
41	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
42	ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	11.0
43	RET	ret proto-oncogene	11.0	Publications
44	B2M	beta-2-microglobulin	11.0	Publications
45	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
46	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.0	Publications
47	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
48	XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	11.0	Publications
49	GAST	gastrin	11.0	Publications
50	PGR	progesterone receptor	11.0	Publications

Pathways related to neuroma according to GeneDecks:

(show all 46)

id	Pathway	Score	Top Affiliating Genes
1	Dual incision reaction in GG-NER38	10.7	ERCC4, ERCC5, XPC, RAD23B
2	Homologous recombination20	10.6	XRCC3, XRCC2, RAD52, RAD51, NBN
3	Resolution of AP sites via the single-nucleotide replacement pathway38	10.6	POLB, OGG1, APEX1, XRCC1, MUTYH
4	Nucleotide excision repair20	10.5	ERCC4, ERCC5, XPC, LIG1, RAD23B, PCNA
5	Nucleotide Excision Repair Pathway36	10.5	ERCC4, ERCC5, XPC, LIG1, LIG4, RAD23B
6	DNA damage_Role of Brca1 and Brca2 in DNA repair41	10.3	NBN, BRIP1, RAD51, XPC, MSH2, POLB
7	DNA damage Role of Brca1 and Brca2 in DNA repair10	10.3	POLB, PCNA, NBN, BRIP1, RAD51, XPC
8	Base excision repair20	10.3	POLB, OGG1, APEX1, XRCC1, MUTYH, PARP1
9	DNA Damage3	10.3	APEX1, MGMT, MSH2, XRCC1, MUTYH, RAD52
10	Assembly of the RAD51-ssDNA nucleoprotein complex38	10.3	RAD52, RAD51
11	Cell Cycle / Checkpoint Control3	10.1	APEX1, MGMT, MSH2, XRCC1, MUTYH, RAD52
12	Passive Transport by Aquaporins38	10.0	AQP6, AQP4, AQP1
13	Apoptosis and survival Role of CDK5 in neuronal death and survival10	9.9	NGF, ERBB3
14	Apoptotic Pathways in Synovial Fibroblasts36	9.4	TGFB1, NGFR, NRG1, IL6, FGF1, SEMA3A
15	p53 Mediated Apoptosis36	9.4	TGFB1, NGFR, NRG1, IL6, FGF1, SEMA3A
16	Pathways in cancer20	9.4	SLC2A1, TGFB1, MAPK10, FGF1, MSH2, RAD51
17	Molecular Mechanisms of Cancer36	9.4	EPOR, TGFB1, NRG1, ERBB3, IL6, FGF1
18	Nanog in Mammalian ESC Pluripotency36	9.3	EPOR, TGFB1, NRG1, ERBB3, IL6, FGF1
19	Telomerase Components in Cell Signaling36	9.3	TGFB1, NGFR, NRG1, IL6, FGF1, SEMA3A
20	JNK Pathway36	9.3	EPOR, TGFB1, NGFR, NRG1, MAPK10, IL6
21	Paxillin Interactions36	9.2	EPOR, NRG1, ERBB3, MAPK10, FGF1, SEMA3A
22	Ras Pathway36	9.2	EPOR, NRG1, ERBB3, MAPK10, FGF1, SEMA3A
23	Rap1 Pathway36	9.2	EPOR, TGFB1, NRG1, ERBB3, IL6, FGF1
24	Breast Cancer Regulation by Stathmin136	9.2	NGFR, NRG1, ERBB3, MAPK10, FGF1, SEMA3A
25	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.1	NGFR, NGF, NRG1, ERBB3, MAPK10
26	Mitochondrial Apoptosis36	9.1	TGFB1, NGFR, NRG1, IL6, FGF1, SEMA3A
27	DHA Signaling36	9.1	NGFR, NRG1, IL6, FGF1, SEMA3A, TGFB1
28	DNA Repair Mechanisms36	9.1	PCNA, POLB, OGG1, ERCC4, ERCC5, ERCC2
29	Pancreatic Adenocarcinoma36	9.1	EPOR, TGFB1, NRG1, ERBB3, IL6, FGF1
30	14-3-3 Induced Intracellular Signaling36	9.0	EPOR, TGFB1, NRG1, ERBB3, MAPK10, FGF1
31	JAK-STAT Pathway36	9.0	EPOR, TGFB1, NGFR, NRG1, ERBB3, IL6
32	Intracellular Calcium Signaling36	8.9	EPOR, TGFB1, NRG1, TRPV1, ERBB3, IL6
33	Glioma Invasiveness36	8.9	TGFB1, NRG1, MAPK10, IL6, FGF1, SEMA3A
34	p70S6K Signaling36	8.9	TGFB1, NGFR, NRG1, MAPK10, IL6, FGF1
35	eNOS Signaling36	8.9	EPOR, TGFB1, NRG1, ERBB3, AQP6, AQP4
36	Renin-Angiotensin Pathway36	8.9	TGFB1, NGFR, NRG1, MAPK10, IL6, FGF1
37	NF-KappaB (p50-p65) Pathway36	8.8	TGFB1, NGFR, NRG1, IL6, FGF1, SEMA3A
38	NFAT in Immune Response36	8.8	EPOR, TGFB1, NRG1, ERBB3, MAPK10, IL6
39	Estrogen Pathway36	8.8	EPOR, TGFB1, NRG1, ERBB3, MAPK10, IL6
40	GPCR Pathway36	8.8	EPOR, TGFB1, NRG1, ERBB3, MAPK10, IL6
41	TGF-Beta Pathway36	8.8	TGFB1, NGFR, NRG1, MAPK10, IL6, FGF1
42	GSK3 Signaling36	8.8	EPOR, TGFB1, NRG1, ERBB3, MAPK10, IL6
43	Tec Kinases Signaling36	8.8	EPOR, TGFB1, NGFR, NRG1, ERBB3, MAPK10
44	MAPK Signaling36	8.6	EPOR, TGFB1, NGFR, NRG1, ERBB3, MAPK10
45	Rho Family GTPases36	8.4	EPOR, TGFB1, GFAP, NRG1, ERBB3, MAPK10
46	Neuroscience3	8.4	NGFR, NF2, GFAP, GAP43, NGF, SSTR1

Compounds related to neuroma according to GeneDecks:

(show top 50)    (show all 165)

id	Compound	Score	Top Affiliating Genes
1	polynucleotide32	10.3	RAD51, LIG1, XRCC1, XRCC4, POLB, APEX1
2	8-oxoguanine32	10.2	OGG1, APEX1, POLB, MGMT, XRCC1, MUTYH
3	melphalan32 9 9	12.1	POLB, ERCC4, ERCC2, MGMT, XRCC3, RAD51
4	methylmethanesulfonate32	10.1	APEX1, POLB, PCNA, OGG1, RAD51, RAD52
5	mitomycin c32	10.0	XRCC3, POLB, NBN, RAD51, MGMT, XRCC2
6	threonine32	9.9	NF2, NRG1, MSN, NBN, RDX, RET
7	mnng32	9.9	POLB, PCNA, XRCC1, MSH2, MGMT, PARP1
8	ly29400232	9.8	SLC2A1, IL6, GDNF, XPC, VHL, EPOR
9	8-oxo-dg32	9.8	POLB, OGG1, APEX1, MUTYH, LIG1, PCNA
10	thymidylate32	9.8	ERCC2, MKI67, ERCC4, MSH2, B2M, XRCC1
11	folate32	9.6	XRCC1, VHL, XRCC3, CCK, MGMT, MKI67
12	agar32	9.4	EPOR, PGR, SLC2A1, NF2, RET, CD34
13	camptothecin32 42 9 9	12.2	NBN, NGF, APEX1, MGMT, RAD51, XRCC2
14	glucose32	8.8	VHL, GDNF, GAST, SLC2A1, SSTR1, ERBB3
15	bromodeoxyuridine32	8.5	APEX1, FGF1, MKI67, S100B, PCNA, GDNF
16	5fluorouracil32	8.3	SLC2A1, MAPK10, XRCC1, MKI67, MSH2, PCNA
17	cisplatin32 34 9 9	11.3	NRG1, GFAP, TGFB1, GAST, EPOR, SLC2A1
18	gaba32 42	9.2	NRG1, GFAP, TRPV1, P2RX7, GDNF, S100B
19	phosphotyrosine32	8.2	SSTR1, ERBB3, EZR, FGF1, MSN, RDX
20	formaldehyde32 18	9.1	MKI67, MAPK10, APEX1, FGF1, MGMT, GFAP
21	glutamate32	8.0	APEX1, TRPV1, PCNA, OGG1, SLC2A1, EPOR
22	cysteine32	7.9	APEX1, AQP4, AQP1, MGMT, PARP1, PCNA
23	atp32	7.9	RAD51, FKBP4, MSH2, P2RX7, XPC, PARP1
24	oligonucleotide32	7.9	GDNF, GAP43, EPOR, POLB, XPC, OGG1
25	wortmannin32 42	8.8	NGF, NGFR, SLC2A1, GDNF, EZR, MAPK10
26	paclitaxel32 34 9 9	10.8	ERCC2, MAPK10, MKI67, S100B, PARP1, NRG1
27	dopamine32 9 18 9	10.7	RET, S100B, CCK, TRPV1, SST, SSTR1
28	arginine32	7.6	S100B, SST, POLB, FGF1, GFAP, RET
29	choline32 9 18 9	10.5	S100B, P2RX7, SST, NGF, NGFR, RET
30	phosphatidylinositol32	7.5	NF1, GDNF, VHL, MSN, GAP43, NGFR
31	lactate32	7.4	MGMT, S100B, P2RX7, PCNA, GFAP, B2M
32	glutamine32	7.2	OGG1, SLC2A1, PGR, TGFB1, GFAP, NGF
33	acetylcholine32 9 18 9	10.2	NGFR, S100B, GDNF, GAST, GAP43, GFAP
34	cyclosporin a32 42	8.2	PGR, TGFB1, NGF, TRPV1, CALCA, S100B
35	genistein32 9 18 9	10.0	SST, PGR, SLC2A1, GFAP, NGF, ERBB3
36	paraffin32	6.9	EZR, EPOR, PGR, ERBB3, SSTR1, NRG1
37	testosterone32 9 18 9	9.7	GAST, PGR, GFAP, NGF, PCNA, RET
38	cycloheximide32	6.7	RAD51, PARP1, B2M, MKI67, MAPK10, SST
39	adenylate32	6.6	PGR, FGF1, APEX1, MAPK10, CCK, EZR
40	lipid32	6.6	ERBB3, RET, S100B, AQP1, RDX, FGF1
41	forskolin32 42 9 9	9.5	AQP1, FGF1, S100B, NRG1, MAPK10, ERBB3
42	thymidine32 18	7.5	PCNA, ERCC4, MAPK10, IL6, FGF1, MGMT
43	calcium32 9 18 9	9.4	FKBP4, TRPV1, ERBB3, EZR, CCK, MAPK10
44	dexamethasone32 42 34 9 9	10.4	GFAP, GAP43, S100B, MGMT, GAST, FGF1
45	alanine32	6.2	RET, PCNA, RAD51, LIG1, XRCC4, S100B
46	estrogen32	6.2	GDNF, MKI67, CD34, MSN, B2M, S100B
47	retinoic acid32 42 18	8.0	MGMT, RET, PARP1, B2M, GDNF, GAP43
48	vegf32	4.8	RET, PCNA, SEMA3A, MAPK10, CALCA, ERBB3
49	tyrosine32	4.7	MKI67, NF1, NF2, GFAP, SLC2A1, EPOR
50	serine32	4.6	SLC2A1, EPOR, GAP43, GAST, GDNF, OGG1

Cellular components related to neuroma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	extrinsic to membrane	GO:019898	10.3	NF2, EZR, MSN, RDX
2	condensed chromosome	GO:000793	10.3	MKI67, XRCC4, LIG4, RAD51
3	filopodium membrane	GO:031527	10.1	GAP43, NF2, MSN
4	DNA ligase IV complex	GO:032807	10.0	XRCC4, LIG4
5	basolateral plasma membrane	GO:016323	9.6	SLC2A1, ERBB3, EZR, ANK3, AQP4, AQP1
6	nucleolus	GO:005730	8.9	FKBP4, FGF1, APEX1, EZR, NF2, OGG1
7	nucleoplasm	GO:005654	8.5	PGR, MGMT, APEX1, MAPK10, ERCC2, ERCC5
8	integral to plasma membrane	GO:005887	8.3	EPOR, NGFR, NRG1, SSTR1, TRPA1, TRPV1
9	extracellular space	GO:005615	8.1	TGFB1, NGF, CRLF1, NRG1, SST, ERBB3
10	extracellular region	GO:005576	7.0	GAST, EPOR, TGFB1, NGFR, NGF, NRG1
11	nucleus	GO:005634	6.8	ERCC2, ERBB3, CALCA, APEX1, AQP1, MGMT
12	cytoplasm	GO:005737	6.5	APEX1, CALCA, ERCC2, NRG1, CRLF1, NF1

Biological processes related to neuroma according to GeneDecks:

(show all 27)

id	Name	GO ID	Score	Top Affiliating Genes
1	UV protection	GO:009650	10.5	ERCC2, ERCC5, ERCC4
2	nucleotide-excision repair, DNA gap filling	GO:006297	10.5	POLB, LIG1, LIG4, PCNA
3	DNA ligation involved in DNA repair	GO:051103	10.5	LIG4, LIG1, XRCC4
4	nucleotide-excision repair, DNA damage removal	GO:000718	10.5	ERCC4, ERCC5, ERCC2, XPC, RAD23B
5	double-strand break repair via homologous recombination	GO:000724	10.5	ERCC4, XRCC2, LIG1, RAD52, RAD51, NBN
6	transcription-coupled nucleotide-excision repair	GO:006283	10.4	ERCC4, ERCC5, ERCC2, LIG1, PCNA
7	response to X-ray	GO:010165	10.4	LIG4, XRCC2, XRCC4, MSH2
8	isotype switching	GO:045190	10.4	MSH2, XRCC4, LIG4, NBN
9	telomere maintenance	GO:000723	10.4	RTEL1, ERCC4, PARP1, LIG1, NBN, PCNA
10	nucleotide-excision repair, DNA damage recognition	GO:000715	10.4	RAD23B, XPC
11	positive regulation of neurogenesis	GO:050769	10.3	XRCC4, XRCC2, LIG4
12	double-strand break repair	GO:006302	10.3	XRCC4, LIG1, LIG4, RAD52, RAD51, BRIP1
13	nucleotide-excision repair	GO:006289	10.3	OGG1, ERCC4, ERCC5, ERCC2, XPC, LIG1
14	base-excision repair	GO:006284	10.3	POLB, OGG1, APEX1, XRCC1, MUTYH, PARP1
15	mismatch repair	GO:006298	10.2	MSH2, MUTYH, PCNA
16	response to pain	GO:048265	10.2	TRPA1, CALCA, RET
17	positive regulation of fibroblast proliferation	GO:048146	10.2	NGFR, AQP1, XRCC4, LIG4
18	meiosis	GO:007126	10.1	NBN, RAD51, XRCC2, MKI67
19	negative regulation of MAPK cascade	GO:043409	10.1	NF2, NF1, P2RX7
20	sympathetic nervous system development	GO:048485	10.0	SEMA3A, NF1, GDNF
21	regulation of heart rate	GO:002027	9.6	CALCA, SCN10A, SEMA3A
22	negative regulation of neuron apoptotic process	GO:043524	9.4	GDNF, NGF, CRLF1, ERBB3, MSH2, XRCC4
23	cell proliferation	GO:008283	9.4	NRG1, ERCC2, MKI67, CD34, S100B, LIG4
24	peripheral nervous system development	GO:007422	9.4	NF1, NGF, NRG1, ERBB3
25	response to wounding	GO:009611	9.2	NGFR, GFAP, TGFB1, GAP43
26	DNA repair	GO:006281	9.1	PCNA, XPC, MSH2, MGMT, APEX1, ERCC2
27	response to drug	GO:042493	8.2	TRPA1, SST, NGF, ABCA2, TGFB1, ERBB3

Molecular functions related to neuroma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	endodeoxyribonuclease activity	GO:004520	10.4	APEX1, ERCC5, ERCC4
2	MutLalpha complex binding	GO:032405	10.3	MSH2, MUTYH, PCNA
3	single-stranded DNA binding	GO:003697	10.3	ERCC4, ERCC5, MSH2, XPC, RAD23B, RAD51
4	ATP-dependent DNA helicase activity	GO:004003	10.2	RTEL1, ERCC2, BRIP1, NBN
5	endonuclease activity	GO:004519	10.1	MUTYH, APEX1, ERCC5, OGG1
6	protein N-terminus binding	GO:047485	10.1	TGFB1, ERCC4, ERCC5, ERCC2, PARP1, NBN
7	damaged DNA binding	GO:003684	10.1	POLB, OGG1, ERCC4, APEX1, XPC, XRCC1
8	protein C-terminus binding	GO:008022	10.0	ERCC4, ERCC2, MKI67, MSH2, XRCC4, LIG4
9	4 iron, 4 sulfur cluster binding	GO:051539	9.9	RTEL1, ERCC2, MUTYH, BRIP1
10	growth factor activity	GO:008083	8.7	FGF1, IL6, NRG1, NGF, TGFB1, GDNF
11	ATP binding	GO:005524	8.4	FKBP4, MAPK10, ERBB3, ERCC2, TRPV1, ABCA2
12	protein binding	GO:005515	4.9	GAP43, ERCC2, ERBB3, GLTSCR1, CALCA, EZR