NMO
MCID: NRM001
MIFTS: 59

Neuromyelitis Optica (NMO) malady

Rare diseases, Neuronal diseases, Eye diseases categories
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Summaries for Neuromyelitis Optica

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NINDS:43 Neuromyelitis optica (NMO) is an uncommon disease syndrome of the central nervous system (CNS) that affects the optic nerves and spinal cord. Individuals with NMO develop optic neuritis, which causes pain in the eye and vision loss, and transverse myelitis, which causes weakness, numbness, and sometimes paralysis of the arms and legs, along with sensory disturbances and loss of bladder and bowel control. NMO leads to loss of myelin, which is a fatty substance that surrounds nerve fibers and helps nerve signals move from cell to cell. The syndrome can also damage nerve fibers and leave areas of broken-down tissue. In the disease process of NMO, for reasons that aren't yet clear, immune system cells and antibodies attack and destroy myelin cells in the optic nerves and the spinal cord.

MalaCards based summary: Neuromyelitis Optica, also known as devic disease, is related to multiple sclerosis and acute disseminated encephalomyelitis. An important gene associated with Neuromyelitis Optica is AQP4 (aquaporin 4), and among its related pathways are Amino sugar and nucleotide sugar metabolism and Bile secretion. The compounds chitin and N-Acetyl-D-glucosamine have been mentioned in the context of this disorder. Affiliated tissues include eye, optic nerve and spinal cord, and related mouse phenotype immune system.

Disease Ontology:8 A central nervous system disease characterized by acute neuritis located in eye and characterized by demyelination located in optic nerve and located in spinal cord

Genetics Home Reference:21 Neuromyelitis optica is an autoimmune disorder that affects the nerves of the eyes and the central nervous system, which includes the brain and spinal cord. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. In neuromyelitis optica, the autoimmune attack causes inflammation of the nerves, and the resulting damage leads to the signs and symptoms of the condition.

NIH Rare Diseases:42 Devic disease, is an autoimmune disease affecting the spinal cord and optic nerves (the nerves that carry information regarding sight from the eye). in devic disease the protective outer covering of the nerves (myelin) is lost. the syndrome can also damage nerve fibers and leave areas of broken-down tissue.  signs and symptoms worsen with time and include optic neuritis, transverse myelitis, sensory impairment, and bladder and bowel dysfunction. currently there is no cure for devic disease, but there are therapies to treat an attack while it is happening, to reduce symptoms, and to prevent relapses. in its early stages, devic disease may be confused with multiple sclerosis.  last updated: 10/13/2010

Wikipedia:65 Neuromyelitis optica (NMO), also known as Devic\'s disease or Devic\'s syndrome, is a heterogeneous... more...

Aliases & Classifications for Neuromyelitis Optica

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Sources:
30LifeMap Discovery¬ģ, 8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 27ICD9CM, 39NCIt, 57SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Neuromyelitis Optica, Aliases & Descriptions:

Name: Neuromyelitis Optica 30 8 42 21 43 10 44 48 62
Devic Disease 42 21 48
Devic's Neuromyelitis Optica 42 62
Devic's Syndrome 8 43
Devic's Disease 8 21
 
Optic-Spinal Ms 21 62
Opticospinal Ms 21 62
Devic Syndrome 42 21
Devic Neuromyelitis Optica 21
Nmo 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Eye diseases


Characteristics (Orphanet epidemiological data):

48
neuromyelitis optica:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


External Ids:

Disease Ontology8 DOID:8869
ICD9CM27 341.0
NCIt39 C84934
MeSH34 D009471
SNOMED-CT57 25044007
MESH via Orphanet35 D009471
ICD10 via Orphanet26 G36.0
UMLS via Orphanet63 C0027873
ICD1025 G36.0

Related Diseases for Neuromyelitis Optica

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Diseases in the Neuromyelitis Optica family:

Neuromyelitis Optica Spectrum Disorder

Diseases related to Neuromyelitis Optica via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1multiple sclerosis31.6CHIT1, HCRT, AQP4
2acute disseminated encephalomyelitis31.5AQP4
3demyelinating disease31.0AQP4, HCRT
4neuromyelitis optica spectrum disorder11.1
5neuritis11.0
6optic neuritis11.0
7myelitis10.9
8transverse myelitis10.8
9retinitis10.7
10myasthenia gravis10.6
11cerebritis10.6
12systemic lupus erythematosus10.6
13lupus erythematosus10.6
14neuropathy10.6
15dystonia10.5
16hematopoietic stem cell transplantation10.5
17leber hereditary optic neuropathy10.5
18cervicitis10.5
19connective tissue disease10.5
20encephalitis10.5
21tuberculosis10.5
22celiac disease10.4
23pulmonary tuberculosis10.4
24relapsing-remitting multiple sclerosis10.4
25internuclear ophthalmoplegia10.4
26narcolepsy10.4
27neuronitis10.4
28cholesterol embolism10.4
29influenza10.4
30ophthalmoplegia10.4
31paraplegia10.4
32syndrome of inappropriate antidiuretic hormone10.4
33myelinoclastic diffuse sclerosis10.4
34amyotrophic lateral sclerosis10.2
35autoimmune hepatitis10.2
36b-cell lymphomas10.2
37follicular lymphoma10.2
38hepatitis10.2
39parkinson's disease10.2
40pemphigus foliaceus10.2
41lateral sclerosis10.2
42syringomyelia10.2
43autoimmune lymphoproliferative syndrome10.2
44moyamoya disease10.2
45pemphigus10.2
46mumps10.2
47miller fisher syndrome10.2
48primary progressive multiple sclerosis10.2
49subacute sclerosing panencephalitis10.2
50japanese encephalitis10.2

Graphical network of the top 20 diseases related to Neuromyelitis Optica:



Diseases related to neuromyelitis optica

Symptoms for Neuromyelitis Optica

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Drugs & Therapeutics for Neuromyelitis Optica

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Drug clinical trials:

Search ClinicalTrials for Neuromyelitis Optica

Search NIH Clinical Center for Neuromyelitis Optica

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Neuromyelitis Optica cell therapies at LifeMap Discovery.

Genetic Tests for Neuromyelitis Optica

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Anatomical Context for Neuromyelitis Optica

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MalaCards organs/tissues related to Neuromyelitis Optica:

32
Spinal cord, Eye, Brain, T cells, B cells, Testes, Neutrophil, Cortex, Skeletal muscle, Prostate, Hypothalamus

FMA organs/tissues related to Neuromyelitis Optica:

14
Eye, Optic nerve

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Neuromyelitis Optica:
id TissueAnatomical CompartmentCell Relevance
1 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Neuromyelitis Optica or affiliated genes

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MGI Mouse Phenotypes related to Neuromyelitis Optica:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.6IL17F, IFI30, CHIT1, AQP4

Publications for Neuromyelitis Optica

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Articles related to Neuromyelitis Optica:

(show top 50)    (show all 631)
idTitleAuthorsYear
1
A case of classic neuromyelitis optica (Devic's syndrome) triggered by pegylated-interferon I+. (25271052)
2014
2
A Case of Neuromyelitis Optica Masquerading as Miller Fisher Syndrome. (25408664)
2014
3
A case of neuromyelitis optica spectrum disorder with early successful induction of double filtration plasmapheresis. (24965298)
2014
4
A case of pathology-proven neuromyelitis optica spectrum disorder with SjAPgren syndrome manifesting aphasia and apraxia due to a localized cerebral white matter lesion. (24986696)
2014
5
Transverse myelitis associated with an itchy rash and hyperckemia: neuromyelitis optica associated with dermatitis herpetiformis. (24637913)
2014
6
IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis. (23726764)
2013
7
Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica. (23910387)
2013
8
The epidemiology of neuromyelitis optica amongst adults in the Merseyside county of United Kingdom. (23689970)
2013
9
Aquaporin-4 autoantibodies in Neuromyelitis Optica: AQP4 isoform-dependent sensitivity and specificity. (24260168)
2013
10
Ultrahigh-Field MR (7a88T) Imaging of Brain Lesions in Neuromyelitis Optica. (23431447)
2013
11
Longitudinal follow-up of vision in a neuromyelitis optica cohort. (23413296)
2013
12
The usefulness of brain MRI at onset in the differentiation of multiple sclerosis and seropositive neuromyelitis optica spectrum disorders. (24072726)
2013
13
Persisting myelin oligodendrocyte glycoprotein antibodies in aquaporin-4 antibody negative pediatric neuromyelitis optica. (23257621)
2013
14
Hypogeusia as a symptom of neuromyelitis optica spectrum disorder. (23319070)
2013
15
Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica. (23563310)
2013
16
Factors associated with the effectiveness of plasma exchange for the treatment of NMO-IgG-positive neuromyelitis optica spectrum disorders. (23263897)
2013
17
Interferon alpha association with neuromyelitis optica. (24348680)
2013
18
Visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis. (23807832)
2013
19
Helicobacter pylori infection in Neuromyelitis Optica and Multiple Sclerosis. (23295676)
2013
20
Neuromyelitis optica: clinical manifestations and neuroimaging features. (23186898)
2013
21
Factors associated with the time to next attack in neuromyelitis optica: accelerated failure time models with random effects. (24358171)
2013
22
Evaluation of inner retinal layers in patients with multiple sclerosis or neuromyelitis optica using optical coherence tomography. (23084127)
2013
23
Possible second motor neuron damage in neuromyelitis optica. (24113331)
2013
24
Illuminating neuromyelitis optica pathogenesis. (22308524)
2012
25
Anti-aquaporin-4 antibody-positive definite neuromyelitis optica in a patient with thymectomy for myasthenia gravis. (22367834)
2012
26
Neuromyelitis optica: an antibody-mediated disorder of the central nervous system. (22363840)
2012
27
Reduced serum uric acid levels in neuromyelitis optica: serum uric acid levels are reduced during relapses in NMO. (22309305)
2012
28
Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder. (22146605)
2012
29
Aquaporin-4 Mz isoform: brain expression, supramolecular assembly and neuromyelitis optica antibody binding. (21491501)
2011
30
Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. (21321193)
2011
31
Efficacy and safety of rituximab in pediatric neuromyelitis optica. (21183724)
2011
32
The prevalence of long spinal cord lesions and anti-aquaporin 4 antibodies in neuromyelitis optica patients in Taiwan. (21273778)
2011
33
Neuromyelitis optica spectrum disorder in patients with connective tissue disease and myelitis. (21523924)
2011
34
Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica. (21552296)
2011
35
Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis. (21159721)
2011
36
Neuromyelitis optica and astrocytic damage in its pathogenesis. (21396661)
2011
37
The rescue effect of plasma exchange for neuromyelitis optica. (20888238)
2011
38
Association of Th1/Th2-related chemokine receptors in peripheral T cells with disease activity in patients with multiple sclerosis and neuromyelitis optica. (21846991)
2011
39
Does detection of anti-AQP4 antibodies trump clinical criteria for neuromyelitis optica? (21813783)
2011
40
Neuromyelitis optica: a review. (21958184)
2011
41
Functional characterization of aquaporin-4 specific T cells: towards a model for neuromyelitis optica. (21264240)
2011
42
Autoimmunity in neuromyelitis optica and opticospinal multiple sclerosis: astrocytopathy as a common denominator in demyelinating disorders. (21962794)
2011
43
Bilateral Internuclear Ophthalmoplegia in a Patient with Devic's Neuromyelitis Optica. (21113284)
2010
44
Symptomatic narcolepsy in patients with neuromyelitis optica and multiple sclerosis: new neurochemical and immunological implications. (20008665)
2009
45
Clinical course of optic neuritis in patients with relapsing neuromyelitis optica. (18195212)
2008
46
Neuromyelitis optica]. (17934711)
2007
47
Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression. (16831965)
2006
48
Activation of humoral immunity and eosinophils in neuromyelitis optica. (15623701)
2004
49
Neuromyelitis optica (Devic's syndrome): no association with the primary mitochondrial DNA mutations found in Leber hereditary optic neuropathy. (9010406)
1997
50
Devic's neuromyelitis optica and Schilder's myelinoclastic diffuse sclerosis. (1343820)
1992

Variations for Neuromyelitis Optica

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Expression for genes affiliated with Neuromyelitis Optica

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Expression patterns in normal tissues for genes affiliated with Neuromyelitis Optica

Search GEO for disease gene expression data for Neuromyelitis Optica.

Pathways for genes affiliated with Neuromyelitis Optica

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Pathways related to Neuromyelitis Optica according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
colanic acid building blocks biosynthesis37
N-acetylglucosamine degradation I37
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)37
UDP-D-xylose and UDP-D-glucuronate biosynthesis37
N-acetylglucosamine degradation II37
UDP-N-acetyl-D-glucosamine biosynthesis II37
UDP-N-acetyl-D-galactosamine biosynthesis II37
GDP-L-fucose biosynthesis I (from GDP-D-mannose)37
9.3CHIA, CHIT1
29.3AQP4, CYP7A1

Compounds for genes affiliated with Neuromyelitis Optica

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 28IUPHAR
See all sources

Compounds related to Neuromyelitis Optica according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1chitin44 2410.4CHIA, CHIT1
2N-Acetyl-D-glucosamine24 1110.2CHIA, CHIT1
3dexamethasone44 50 28 1111.8CYP7A1, HCRT, AQP4
4Water248.1AQP4, CHIT1, CHIA, CYP7A1
5lipid447.7CYP7A1, HCRT, CHIT1, CHIA

GO Terms for genes affiliated with Neuromyelitis Optica

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Cellular components related to Neuromyelitis Optica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057649.1IFI30, CHIT1
2extracellular spaceGO:0056158.9IL17F, CHIA, CHIT1

Biological processes related to Neuromyelitis Optica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chitin catabolic processGO:0060329.3CHIA, CHIT1
2polysaccharide catabolic processGO:0002729.0CHIA, CHIT1

Molecular functions related to Neuromyelitis Optica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chitinase activityGO:0045689.3CHIA, CHIT1
2chitin bindingGO:0080619.0CHIA, CHIT1

Products for genes affiliated with Neuromyelitis Optica

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  • Antibodies
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Sources for Neuromyelitis Optica

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet