MCID: NRN016
MIFTS: 41

Neuronal Migration Disorders malady

Category: Neuronal diseases

Aliases & Classifications for Neuronal Migration Disorders

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Aliases & Descriptions for Neuronal Migration Disorders:

Name: Neuronal Migration Disorders 47 25
 
Malformations of Cortical Development, Group Ii 66

Classifications:



Summaries for Neuronal Migration Disorders

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NINDS:47 Neuronal migration disorders (NMDs) are a group of birth defects caused by the abnormal migration of neurons in the developing brain and nervous system. In the developing brain, neurons must migrate from the areas where they are born to the areas where they will settle into their proper neural circuits. Neuronal migration, which occurs as early as the second month of gestation, is controlled by a complex assortment of chemical guides and signals. When these signals are absent or incorrect, neurons do not end up where they belong. This can result in structurally abnormal or missing areas of the brain in the cerebral hemispheres, cerebellum, brainstem, or hippocampus. The structural abnormalities found in NMDs include schizencephaly, porencephaly, lissencephaly, agyria, macrogyria, polymicrogyria, pachygyria, microgyria, micropolygyria, neuronal heterotopias (including band heterotopia), agenesis of the corpus callosum, and agenesis of the cranial nerves. Symptoms vary according to the abnormality, but often feature poor muscle tone and motor function, seizures, developmental delays, impaired cognitive development, failure to grow and thrive, difficulties with feeding, swelling in the extremities, and a smaller than normal head. Most infants with an NMD appear normal, but some disorders have characteristic facial or skull features that can be recognized by a neurologist. Several genetic abnormalities in children with NMDs have been identified. Defects in genes that are involved in neuronal migration have been associated with NMDs, but the role they play in the development of these disorders is not yet well-understood. More than 25 syndromes resulting from abnormal neuronal migration have been described. Among them are syndromes with several different patterns of inheritance; genetic counseling thus differs greatly between syndromes.

MalaCards based summary: Neuronal Migration Disorders, also known as malformations of cortical development, group ii, is related to 2q33.1 microdeletion syndrome and dfnx1 nonsyndromic hearing loss and deafness. An important gene associated with Neuronal Migration Disorders is DCX (Doublecortin), and among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Cytoskeletal Signaling. Affiliated tissues include brain, cerebellum and cortex, and related mouse phenotypes are reproductive system and growth/size/body region.

Wikipedia:69 Nervous system disease refers to a general class of medical conditions affecting the nervous system. more...

Related Diseases for Neuronal Migration Disorders

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Diseases related to Neuronal Migration Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
12q33.1 microdeletion syndrome10.8MAP2, VIM
2dfnx1 nonsyndromic hearing loss and deafness10.7DCX, PAFAH1B1
3epilepsy, familial temporal lobe, 710.7PAFAH1B1, RELN
4premature ovarian failure 810.7PAFAH1B1, RELN
5chromosome 17p13.3 duplication syndrome10.7PAFAH1B1, YWHAE
6neuronitis10.7
7noonan syndrome 1010.7DCX, PAFAH1B1
8subaortic stenosis, membranous10.6PAFAH1B1, YWHAE
9dcma syndrome10.6DCX, PAFAH1B1
10retinitis pigmentosa 1310.6DCX, PAFAH1B1, RELN
11epithelial and subepithelial dystrophy10.6PAFAH1B1, YWHAE
12pseudopelade of brocq10.6DCX, PAFAH1B1, RELN
13mental retardation, x-linked, syndromic 1510.5ARX, DCX, PAFAH1B1
14sm-ahnmd10.5NES, VIM
15intracystic papillary adenoma10.5MAP2, NES
16lymph node tuberculosis10.4NES, YWHAE
17congenital hypogammaglobulinemia10.4MAP2, NES, VIM
18adenomyoma of uterine corpus10.4MAP2, NES, VIM
19primary syphilis10.4MAP2, VIM
20ependymoblastoma10.3NES, VIM
21mckusick type metaphyseal dysplasia10.3DCX, FLNA, PAFAH1B1
22familial papillary or follicular thyroid carcinoma10.3PVALB, VIM
23oligoastrocytoma10.3NES, VIM
24epilepsy10.3
25adult central nervous system teratoma10.2CALB1, PVALB
26chronic cholangitis10.0DCX, VLDLR
27anti-p200 pemphigoid10.0MAP1B, MAP2
28osteopetrosis and infantile neuroaxonal dystrophy10.0NES, VIM
29cerebritis10.0
30fibuloulnar aplasia or hypoplasia with renal abnormalities9.9PAFAH1B1, RELN, VLDLR
31antley-bixler syndrome9.9ARFGEF2, DCX, EMX2, FLNA, PAFAH1B1
32lissencephaly 19.9
33pachygyria with mental retardation, seizures, and arachnoid cysts9.9
34flna-related periventricular nodular heterotopia9.9
35colpocephaly9.9
36periventricular nodular heterotopia9.9
37zellweger syndrome9.9
38muscular dystrophy9.9
39pachygyria9.9
40testicular lymphoma9.8CALB1, DCX, PVALB, RELN
41peyronie's disease9.7ARFGEF2, ARX, FLNA, PVALB
42microcephalic osteodysplastic primordial dwarfism, type i9.7
43cerebral palsy9.7
44holoprosencephaly9.7
45temporal lobe epilepsy9.7
46lissencephaly9.7
47walker-warburg syndrome9.7
48pseudobulbar palsy9.7
49dysembryoplastic neuroepithelial tumor9.7
50turner syndrome9.7

Graphical network of the top 20 diseases related to Neuronal Migration Disorders:



Diseases related to neuronal migration disorders

Symptoms for Neuronal Migration Disorders

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Drugs & Therapeutics for Neuronal Migration Disorders

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Drugs for Neuronal Migration Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DopaminePhase 4367851-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
2
levodopaPhase 437959-92-76047
Synonyms:
(-)-(3,4-Dihydroxyphenyl)alanine
(-)-3-(3,4-Dihydroxyphenyl)-L-alanine
(-)-3-(3,4-dihydroxyphenyl)-L-alanine
(-)-Dopa
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
(−)-3-(3,4-dihydroxyphenyl)-L-alanine
(−)-dopa
.Beta.-(3, 4-Dihydroxyphenyl)alanine
.Beta.-(3,4-Dihydroxyphenyl)-L-alanine
1E83F927-C221-46AA-B90A-81B33C5F3868
2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid
23734-74-9
25525-15-9
3, 4-Dihydroxy-L-phenylalanine
3, 4-Dihydroxyphenylalanine
3,4-DIHYDROXYPHENYLALANINE
3,4-Dihydroxy-L-phenylalanine
3,4-Dihydroxyphenyl-L-alanine
3,4-Dihydroxyphenylalanine
3,4-Dihydroxyphenylalanine (VAN)
3,4-dihydroxy-L-phenylalanine
3,4-dihydroxyphenylalanine
3-(3,4-Dihydroxypheny
3-(3,4-Dihydroxyphenyl)-L-alanine
3-Hydroxy-L-tyrosine
34241-25-3
37830_FLUKA
587-45-1
59-92-7
72572-99-7
72573-00-3
88250-23-1
90638-38-3
AC-11686
AC1L1LOR
AC1Q4U7F
BIDD:GT0158
BPBio1_000059
BSPBio_000053
BSPBio_002354
Bendopa
Bio-0575
Biodopa
Brocadopa
C00355
C9H11NO4
CAS-59-92-7
CCRIS 3766
CHEBI:15765
CHEMBL1009
CID6047
Cerepap
Cidandopa
D 9628
D00059
D0600
D9628
D9628_SIGMA
DAH
DB01235
DOPA
Deadopa
Dihydroxy-L-phenylalanine
Dihydroxyphenylalanine
DivK1c_000452
Dopa
Dopaflex
Dopaidan
Dopal
Dopal-Fher
Dopal-fher
Dopalina
Dopar
Dopar (TN)
Doparkine
Doparl
Dopasol
Dopaston
Dopaston SE
Dopastone
Dopastral
Dopicar
Doprin
EINECS 200-445-2
EU-0100454
Eldopal
Eldopar
Eldopatec
Eurodopa
HMS1568C15
HMS1922J14
HMS2090O08
HMS2093N04
HMS501G14
HSDB 3348
Helfo DOPA
 
Helfo-Dopa
Helfo-dopa
IDI1_000452
IV Levodopa
InChI=1/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14
Insulamina
KBio1_000452
KBio2_000934
KBio2_003502
KBio2_006070
KBioGR_001177
KBioSS_000934
L Dopa
L(-)-Dopa
L-(-)-Dopa
L-(3, 4-Dihydroxyphenyl)-.alpha.-alani
L-(3, 4-Dihydroxyphenyl)alanine
L-(o-Dihydroxyphenyl)alanine
L-.Beta.-(3,4-Dihydroxyphenyl)alanine
L-3,4-Dihydroxyphenylalanine
L-3,4-dihydroxyphenylalanine
L-3-(3,4-Dihydroxyphenyl)-Alanine
L-3-(3,4-Dihydroxyphenyl)alanine
L-3-Hydroxytyrosine
L-4-5-Dihydroxyphenylalanine
L-DOPA
L-DOPA, Parcopa, Atamet, Stalevo, Madopar, Prolopa, Dopar, 3,4-Dihydroxyphenylalanine, Levodopa
L-Dihydroxyphenylalanine
L-Dopa
L-O-Dihydroxyphenylalanine
L-b-(3,4-Dihydroxyphenyl)-a-alanine
L-beta-(3,4-Dihydroxyphenyl)-alpha-alanine
L-beta-(3,4-Dihydroxyphenyl)alanine
L-o-Hydroxytyrosine
LS-255
Laradopa
Larodopa
Ledopa
Levedopa
Levodopa
Levodopa (JP15/USP)
Levodopa (JP15/USP/INN)
Levodopa [USAN:INN:BAN:JAN]
Levodopum
Levodopum [INN-Latin]
Levopa
Lopac-D-9628
Lopac0_000454
MLS000028514
Maipedopa
MolPort-000-856-937
NCGC00015384-01
NCGC00016270-01
NCGC00016270-06
NCGC00093869-04
NINDS_000452
NSC 118381
NSC118381
PDSP1_001541
PDSP2_001525
Parda
Pardopa
Prestwick0_000017
Prestwick1_000017
Prestwick2_000017
Prestwick3_000017
Prestwick_185
Prodopa
Ro 4-6316
S1726_Selleck
SDCCGMLS-0066924.P001
SMR000058312
SPBio_000391
SPBio_001974
SPECTRUM2300205
Sobiodopa
Spectrum2_000496
Spectrum4_000539
Spectrum5_001899
Spectrum_000454
Syndopa
UNII-46627O600J
Veldopa
Weldopa
b-(3,4-Dihydroxyphenyl)-L-alanine
b-(3,4-Dihydroxyphenyl)-a-L-alanine
b-(3,4-Dihydroxyphenyl)alanine
beta-(3,4-Dihydroxyphenyl)-L-alanine
beta-(3,4-Dihydroxyphenyl)-alpha-L-alanine
beta-(3,4-Dihydroxyphenyl)-alpha-alanine
beta-(3,4-Dihydroxyphenyl)alanine
bmse000322
component of Sinemet
l)-L-alanine
nchembio.2007.55-comp26
nchembio.89-comp9
ne
β-(3,4-dihydroxyphenyl)alanine
3
protease inhibitors5157
Synonyms:
 
protease inhibitors
4serineNutraceutical883

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled StudyRecruitingNCT01361373Phase 4
2Omega-3 Fatty Acids Efficacy in First-episode of SchizophreniaActive, not recruitingNCT02210962Phase 4
3Mesenchymal Stem Cells for the Treatment of MSActive, not recruitingNCT00781872Phase 1, Phase 2
4Human Epilepsy Genetics--Neuronal Migration Disorders StudyRecruitingNCT00041600
5Investigation of Neuroserpin as an Autism Candidate GeneTerminatedNCT00917683

Search NIH Clinical Center for Neuronal Migration Disorders

Genetic Tests for Neuronal Migration Disorders

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Genetic tests related to Neuronal Migration Disorders:

id Genetic test Affiliating Genes
1 Abnormality of Neuronal Migration25

Anatomical Context for Neuronal Migration Disorders

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MalaCards organs/tissues related to Neuronal Migration Disorders:

34
Brain, Cerebellum, Cortex, Temporal lobe, Skin

Animal Models for Neuronal Migration Disorders or affiliated genes

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MGI Mouse Phenotypes related to Neuronal Migration Disorders:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.0ARX, DCX, EMX2, FLNA, MAP1B, MAP2
2MP:00053787.2ARFGEF2, ARX, DCX, EMX2, FLNA, MAP1B
3MP:00053846.6ADGRG1, ARFGEF2, ARX, EMX2, FLNA, MAP1B
4MP:00107686.4ARFGEF2, ARX, DCX, EMX2, FLNA, MAP1B
5MP:00053865.9ADGRG1, ARX, CALB1, DCX, EMX2, FLNA
6MP:00036315.2ADGRG1, ARFGEF2, ARX, CALB1, DCX, EMX2

Publications for Neuronal Migration Disorders

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Articles related to Neuronal Migration Disorders:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Genotype-phenotype correlation in neuronal migration disorders and cortical dysplasias. (26052266)
2015
2
Rufinamide for the treatment of refractory epilepsy secondary to neuronal migration disorders. (24548548)
2014
3
Cytoskeleton in action: lissencephaly, a neuronal migration disorder. (23495356)
2013
4
Embryonic disruption of the candidate dyslexia susceptibility gene homolog Kiaa0319-like results in neuronal migration disorders. (23831424)
2013
5
Molecular genetics of neuronal migration disorders. (21222180)
2011
6
The beta-tubulin gene TUBB2B is involved in a large spectrum of neuronal migration disorders. (20101787)
2010
7
Neuronal migration disorders. (19245832)
2010
8
Experimental neuronal migration disorders following the administration of ibotenate in hamsters: the role of the subventricular zone in the development of cortical dysplasia. (19258286)
2009
9
Neuronal migration disorders: clinical, neuroradiologic and genetics aspects. (19120042)
2009
10
Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder. (19098909)
2009
11
Neuronal migration disorders, agenesis of corpus callosum, preauricular skin tag and bilateral morning glory syndrome in a term newborn infant. (18388784)
2008
12
Sudden death in a patient with mosaic ring X Turner syndrome and a neuronal migration disorder. (18049086)
2008
13
Reading impairment in the neuronal migration disorder of periventricular nodular heterotopia. (16434687)
2006
14
Grey matter heterotopia: what EEG-fMRI can tell us about epileptogenicity of neuronal migration disorders. (16339793)
2006
15
Neuronal migration disorders, genetics, and epileptogenesis. (15921228)
2005
16
Are altered excitatory synapses found in neuronal migration disorders? (16175215)
2005
17
Reading impairment in the neuronal migration disorder of periventricular nodular heterotopia. (15753412)
2005
18
Proceedings of the International Symposium on Neuronal Migration Disorders and Childhood Epilepsies: clinical manifestations, pathomechanisms, and etiopathogenesis. April 16-17, 2004. Tokyo, Japan. (16044620)
2005
19
Radial and tangential neuronal migration disorder in ibotenate-induced cortical lesions in hamsters: immunohistochemical study of reelin, vimentin, and calretinin. (15072103)
2004
20
High molecular weight microtubule-associated protein 2 over-expression in neuronal migration disorders caused by N-methyl-D-aspartate receptor activation in hamsters. (15008898)
2004
21
Evidence of neuronal migration disorders in Knobloch syndrome: clinical and molecular analysis of two novel families. (12707952)
2003
22
Various findings in surgically treated epilepsy patients with dysembryoplastic neuroepithelial tumors in comparison with those of patients with other low-grade brain tumors and other neuronal migration disorders. (12423388)
2002
23
Presumptive monosomy 21 with neuronal migration disorder re-diagnosed as de novo unbalanced translocation t(18p;21q) by fluorescence in situ hybridisation. (12150215)
2002
24
Neuronal migration disorders. (11553932)
2001
25
Molecular mechanisms of neuronal migration disorders, quo vadis? (11899256)
2001
26
Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. (11709191)
2001
27
Pathogenic significance of neuronal migration disorders in temporal lobe epilepsy. (11431720)
2001
28
Neuronal migration disorders: from genetic diseases to developmental mechanisms. (10906798)
2000
29
Characterization of neuronal migration disorders in neocortical structures: loss or preservation of inhibitory interneurons? (10897147)
2000
30
Neuronal migration disorders in man. (11151046)
2000
31
A novel migration-related gene product, doublecortin, in neuronal migration disorder of fetuses and infants with Zellweger syndrome. (10963364)
2000
32
Immunohistochemical expression of doublecortin in the human cerebrum: comparison of normal development and neuronal migration disorders. (10773210)
2000
33
Electrophysiological responses in vivo of hippocampal CA1 pyramidal neurons in an animal model of neuronal migration disorders. (10575261)
1999
34
The right neuron at the wrong place: biology of heterotopic neurons in cortical neuronal migration disorders, with special reference to associated pathologies. (10487203)
1999
35
Characterization of neuronal migration disorders in neocortical structures: extracellular in vitro recordings. (9786203)
1998
36
Familial neuronal migration disorder: subcortical laminar heterotopia in a mother and pachygyria in the son. (9489790)
1998
37
Neuronal migration disorders: heterotopic neocortical neurons in CA1 provide a bridge between the hippocampus and the neocortex. (9707635)
1998
38
Characterization of neuronal migration disorders in neocortical structures. II. Intracellular in vitro recordings. (9658031)
1998
39
Characterization of neuronal migration disorders in neocortical structures: quantitative receptor autoradiography of ionotropic glutamate, GABA(A) and GABA(B) receptors. (9786204)
1998
40
Mechanisms underlying neuronal migration disorders and epilepsy. (9146989)
1997
41
Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder. (9382874)
1997
42
Positive epileptiform discharges in children with neuronal migration disorders. (9044397)
1997
43
Neuronal migration disorders presenting with mild clinical symptoms. (8703229)
1996
44
Neuronal migration disorders increase susceptibility to hyperthermia-induced seizures in developing rats. (8814104)
1996
45
Electrophysiology of CA1 pyramidal neurons in an animal model of neuronal migration disorders: prenatal methylazoxymethanol treatment. (8777901)
1995
46
Neuronal migration disorders. (7501186)
1995
47
Neuronal migration disorders: positron emission tomography correlations. (8122881)
1994
48
Stages and patterns of centrifugal arrest of diffuse neuronal migration disorders. (8335148)
1993
49
Focal neuronal migration disorders and intractable partial epilepsy: a study of 30 patients. (1789691)
1991
50
Bilateral central macrogyria: epilepsy, pseudobulbar palsy, and mental retardation--a recognizable neuronal migration disorder. (2500888)
1989

Variations for Neuronal Migration Disorders

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Expression for genes affiliated with Neuronal Migration Disorders

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Search GEO for disease gene expression data for Neuronal Migration Disorders.

Pathways for genes affiliated with Neuronal Migration Disorders

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GO Terms for genes affiliated with Neuronal Migration Disorders

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Cellular components related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1microtubule associated complexGO:00058759.7DCX, MAP1B, MAP2, PAFAH1B1
2neuron projectionGO:00430059.1CALB1, DCX, MAP2, PAFAH1B1, VIM
3neuronal cell bodyGO:00430258.7CALB1, FLNA, PAFAH1B1, PVALB
4axonGO:00304248.5CALB1, PAFAH1B1, PVALB, YWHAE

Biological processes related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1cerebral cortex tangential migrationGO:002180010.6ARX, RELN
2positive regulation of dendritic spine morphogenesisGO:006100310.5PAFAH1B1, RELN
3ventral spinal cord developmentGO:002151710.3RELN, VLDLR
4reelin-mediated signaling pathwayGO:003802610.3RELN, VLDLR
5microtubule bundle formationGO:000157810.2MAP1B, MAP2
6cell proliferation in forebrainGO:002184610.2ARX, EMX2
7axon extensionGO:004867510.2DCX, MAP1B
8cerebral cortex regionalizationGO:002179610.2ADGRG1, EMX2
9positive regulation of neural precursor cell proliferationGO:200017910.0ADGRG1, NES
10G2/M transition of mitotic cell cycleGO:00000869.9NES, PAFAH1B1, YWHAE
11layer formation in cerebral cortexGO:00218199.8ADGRG1, DCX, PAFAH1B1, RELN
12central nervous system developmentGO:00074179.8DCX, NES, RELN
13dendrite morphogenesisGO:00488139.7DCX, MAP2, VLDLR
14hippocampus developmentGO:00217669.7DCX, PAFAH1B1, RELN, YWHAE
15cerebral cortex developmentGO:00219879.5EMX2, PAFAH1B1, RELN, VLDLR, YWHAE
16forebrain developmentGO:00309009.4ARX, EMX2, RELN
17neuron migrationGO:00017648.9ARX, DCX, KIAA0319, PAFAH1B1, RELN, YWHAE
18brain developmentGO:00074208.7ADGRG1, DCX, EMX2, NES, PAFAH1B1, RELN

Molecular functions related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:00019489.3FLNA, VIM, VLDLR
2microtubule bindingGO:00080179.3DCX, MAP1B, MAP2, PAFAH1B1
3structural molecule activityGO:00051989.3MAP1B, MAP2, NES, VIM

Sources for Neuronal Migration Disorders

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet