MCID: NRN016
MIFTS: 32

Neuronal Migration Disorders malady

Neuronal diseases category

Aliases & Classifications for Neuronal Migration Disorders

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Aliases & Descriptions for Neuronal Migration Disorders:

Name: Neuronal Migration Disorders 46 65


Classifications:



Summaries for Neuronal Migration Disorders

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NINDS:46 Neuronal migration disorders (NMDs) are a group of birth defects caused by the abnormal migration of neurons in the developing brain and nervous system. In the developing brain, neurons must migrate from the areas where they are born to the areas where they will settle into their proper neural circuits. Neuronal migration, which occurs as early as the second month of gestation, is controlled by a complex assortment of chemical guides and signals. When these signals are absent or incorrect, neurons do not end up where they belong. This can result in structurally abnormal or missing areas of the brain in the cerebral hemispheres, cerebellum, brainstem, or hippocampus. The structural abnormalities found in NMDs include schizencephaly, porencephaly, lissencephaly, agyria, macrogyria, polymicrogyria, pachygyria, microgyria, micropolygyria, neuronal heterotopias (including band heterotopia), agenesis of the corpus callosum, and agenesis of the cranial nerves. Symptoms vary according to the abnormality, but often feature poor muscle tone and motor function, seizures, developmental delays, impaired cognitive development, failure to grow and thrive, difficulties with feeding, swelling in the extremities, and a smaller than normal head. Most infants with an NMD appear normal, but some disorders have characteristic facial or skull features that can be recognized by a neurologist. Several genetic abnormalities in children with NMDs have been identified. Defects in genes that are involved in neuronal migration have been associated with NMDs, but the role they play in the development of these disorders is not yet well-understood. More than 25 syndromes resulting from abnormal neuronal migration have been described. Among them are syndromes with several different patterns of inheritance; genetic counseling thus differs greatly between syndromes.

MalaCards based summary: Neuronal Migration Disorders is related to neuronitis and schwannomatosis-2. An important gene associated with Neuronal Migration Disorders is TUBA1A (Tubulin, Alpha 1a), and among its related pathways are Cytoskeleton remodeling Neurofilaments and Cytoskeletal Signaling. Affiliated tissues include brain, cerebellum and cortex, and related mouse phenotypes are reproductive system and growth/size/body.

Wikipedia:68 Nervous system disease refers to a general class of medical conditions affecting the nervous system. more...

Related Diseases for Neuronal Migration Disorders

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Diseases related to Neuronal Migration Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1neuronitis11.0
2schwannomatosis-210.3DCX, PAFAH1B1
3cerebritis10.3
4progressive demyelinating neuropathy with bilateral striatal necrosis10.3PAFAH1B1, YWHAE
5subcutaneous panniculitis-like t-cell lymphoma10.3DCX, PAFAH1B1
6vestibular neuronitis10.3ARFGEF2, EMX2
7central nervous system sarcoma10.2MAP2, NES
8amyotrophic lateral sclerosis 1810.2DCX, PAFAH1B1, RELN
9tn polyagglutination syndrome, somatic10.2ARX, DCX, PAFAH1B1
10carotenemia10.2NES, VIM
11epidemic typhus10.2NES, VIM
12urethritis10.2MAP2, NES
13hemophagocytic syndrome associated with an infection10.2ARFGEF2, FLNA
14otopalatodigital syndrome, type i10.2ARFGEF2, FLNA
15supratentorial primitive neuroectodermal tumor10.2NES, VIM
16optic nerve hypoplasia10.2DCX, PAFAH1B1
17periventricular nodular heterotopia10.2
18lissencephaly10.2
19zellweger syndrome10.2
20muscular dystrophy10.2
21polymicrogyria10.2
22pachygyria10.2
23odontoma dysphagia syndrome10.2NES, VIM
24selective igg deficiency disease10.2MAP2, NES
25translocation renal cell carcinoma10.2PVALB, VIM
26optic nerve neoplasm10.2MAP2, NES, VIM
27rete ovarii cystadenofibroma10.2MAP2, NES
28low tension glaucoma10.2DCX, NES, VIM
29hypertrichosis of eyelid10.1DCX, VLDLR
30brain meningioma10.1MAP2, NES
31fibrous synovial sarcoma10.1MAP2, VIM
32esophageal tuberculosis10.1CALB1, PVALB
33schizencephaly10.0
34lissencephaly 110.0
35polymicrogyria with seizures10.0
36cerebral palsy10.0
37holoprosencephaly10.0
38temporal lobe epilepsy10.0
39walker-warburg syndrome10.0
40dysembryoplastic neuroepithelial tumor10.0
41pseudobulbar palsy10.0
42diabetes insipidus10.0
43subacute delirium10.0
44dyslexia10.0
45adrenal cortex disease10.0
46adrenocortical carcinoma10.0
47amnestic disorder10.0
48central nervous system disease10.0
49congenital nervous system abnormality10.0
50dementia10.0

Graphical network of the top 20 diseases related to Neuronal Migration Disorders:



Diseases related to neuronal migration disorders

Symptoms for Neuronal Migration Disorders

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Drugs & Therapeutics for Neuronal Migration Disorders

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Drugs for Neuronal Migration Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DopamineapprovedPhase 4281462-31-7, 51-61-6681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine Hcl
Dopamine Hydrochloride
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
 
KBio1_000780
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
2
LevodopaapprovedPhase 433959-92-76047
Synonyms:
(-)-(3,4-Dihydroxyphenyl)alanine
(-)-3-(3,4-Dihydroxyphenyl)-L-alanine
(-)-3-(3,4-dihydroxyphenyl)-L-alanine
(-)-Dopa
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
(−)-3-(3,4-dihydroxyphenyl)-L-alanine
(−)-dopa
.Beta.-(3, 4-Dihydroxyphenyl)alanine
.Beta.-(3,4-Dihydroxyphenyl)-L-alanine
1E83F927-C221-46AA-B90A-81B33C5F3868
2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid
23734-74-9
25525-15-9
3, 4-Dihydroxy-L-phenylalanine
3, 4-Dihydroxyphenylalanine
3,4-DIHYDROXYPHENYLALANINE
3,4-Dihydroxy-L-phenylalanine
3,4-Dihydroxyphenyl-L-alanine
3,4-Dihydroxyphenylalanine
3,4-Dihydroxyphenylalanine (VAN)
3,4-dihydroxy-L-phenylalanine
3,4-dihydroxyphenylalanine
3-(3,4-Dihydroxypheny
3-(3,4-Dihydroxyphenyl)-L-alanine
3-Hydroxy-L-tyrosine
34241-25-3
37830_FLUKA
587-45-1
59-92-7
72572-99-7
72573-00-3
88250-23-1
90638-38-3
AC-11686
AC1L1LOR
AC1Q4U7F
BIDD:GT0158
BPBio1_000059
BSPBio_000053
BSPBio_002354
Bendopa
Bio-0575
Biodopa
Brocadopa
C00355
C9H11NO4
CAS-59-92-7
CCRIS 3766
CHEBI:15765
CHEMBL1009
CID6047
Cerepap
Cidandopa
D 9628
D00059
D0600
D9628
D9628_SIGMA
DAH
DB01235
DOPA
Deadopa
Dihydroxy-L-phenylalanine
Dihydroxyphenylalanine
DivK1c_000452
Dopa
Dopaflex
Dopaidan
Dopal
Dopal-Fher
Dopal-fher
Dopalina
Dopar
Dopar (TN)
Doparkine
Doparl
Dopasol
Dopaston
Dopaston SE
Dopastone
Dopastral
Dopicar
Doprin
EINECS 200-445-2
EU-0100454
Eldopal
Eldopar
Eldopatec
Eurodopa
HMS1568C15
HMS1922J14
HMS2090O08
HMS2093N04
HMS501G14
HSDB 3348
Helfo DOPA
 
Helfo-Dopa
Helfo-dopa
IDI1_000452
IV Levodopa
InChI=1/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14
Insulamina
KBio1_000452
KBio2_000934
KBio2_003502
KBio2_006070
KBioGR_001177
KBioSS_000934
L Dopa
L(-)-Dopa
L-(-)-Dopa
L-(3, 4-Dihydroxyphenyl)-.alpha.-alani
L-(3, 4-Dihydroxyphenyl)alanine
L-(o-Dihydroxyphenyl)alanine
L-.Beta.-(3,4-Dihydroxyphenyl)alanine
L-3,4-Dihydroxyphenylalanine
L-3,4-dihydroxyphenylalanine
L-3-(3,4-Dihydroxyphenyl)-Alanine
L-3-(3,4-Dihydroxyphenyl)alanine
L-3-Hydroxytyrosine
L-4-5-Dihydroxyphenylalanine
L-DOPA
L-DOPA, Parcopa, Atamet, Stalevo, Madopar, Prolopa, Dopar, 3,4-Dihydroxyphenylalanine, Levodopa
L-Dihydroxyphenylalanine
L-Dopa
L-O-Dihydroxyphenylalanine
L-b-(3,4-Dihydroxyphenyl)-a-alanine
L-beta-(3,4-Dihydroxyphenyl)-alpha-alanine
L-beta-(3,4-Dihydroxyphenyl)alanine
L-o-Hydroxytyrosine
LS-255
Laradopa
Larodopa
Ledopa
Levedopa
Levodopa
Levodopa (JP15/USP)
Levodopa (JP15/USP/INN)
Levodopa [USAN:INN:BAN:JAN]
Levodopum
Levodopum [INN-Latin]
Levopa
Lopac-D-9628
Lopac0_000454
MLS000028514
Maipedopa
MolPort-000-856-937
NCGC00015384-01
NCGC00016270-01
NCGC00016270-06
NCGC00093869-04
NINDS_000452
NSC 118381
NSC118381
PDSP1_001541
PDSP2_001525
Parda
Pardopa
Prestwick0_000017
Prestwick1_000017
Prestwick2_000017
Prestwick3_000017
Prestwick_185
Prodopa
Ro 4-6316
S1726_Selleck
SDCCGMLS-0066924.P001
SMR000058312
SPBio_000391
SPBio_001974
SPECTRUM2300205
Sobiodopa
Spectrum2_000496
Spectrum4_000539
Spectrum5_001899
Spectrum_000454
Syndopa
UNII-46627O600J
Veldopa
Weldopa
b-(3,4-Dihydroxyphenyl)-L-alanine
b-(3,4-Dihydroxyphenyl)-a-L-alanine
b-(3,4-Dihydroxyphenyl)alanine
beta-(3,4-Dihydroxyphenyl)-L-alanine
beta-(3,4-Dihydroxyphenyl)-alpha-L-alanine
beta-(3,4-Dihydroxyphenyl)-alpha-alanine
beta-(3,4-Dihydroxyphenyl)alanine
bmse000322
component of Sinemet
l)-L-alanine
nchembio.2007.55-comp26
nchembio.89-comp9
ne
β-(3,4-dihydroxyphenyl)alanine
3DihydroxyphenylalaninePhase 4112
4Omega 3 Fatty AcidNutraceuticalPhase 4890
5OliveNutraceuticalPhase 4212

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled StudyRecruitingNCT01361373Phase 4
2Omega-3 Fatty Acids Efficacy in First-episode of SchizophreniaActive, not recruitingNCT02210962Phase 4
3Mesenchymal Stem Cells for the Treatment of MSActive, not recruitingNCT00781872Phase 1, Phase 2
4Human Epilepsy Genetics--Neuronal Migration Disorders StudyRecruitingNCT00041600
5Epilepsy Phenome/Genome ProjectActive, not recruitingNCT00552045
6Investigation of Neuroserpin as an Autism Candidate GeneNot yet recruitingNCT00917683

Search NIH Clinical Center for Neuronal Migration Disorders

Genetic Tests for Neuronal Migration Disorders

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Anatomical Context for Neuronal Migration Disorders

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MalaCards organs/tissues related to Neuronal Migration Disorders:

33
Brain, Cerebellum, Cortex, Temporal lobe, Skin

Animal Models for Neuronal Migration Disorders or affiliated genes

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MGI Mouse Phenotypes related to Neuronal Migration Disorders:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.5ARX, DCX, EMX2, FLNA, MAP1B, MAP2
2MP:00053787.0ARFGEF2, ARX, DCX, FLNA, MAP1B, MAP2
3MP:00107686.6ARFGEF2, ARX, DCX, EMX2, FLNA, MAP1B
4MP:00053846.1ADGRG1, ARFGEF2, ARX, EMX2, MAP1B, NES
5MP:00053864.9ADGRG1, ARX, CALB1, DCX, EMX2, FLNA
6MP:00036314.1ADGRG1, ARFGEF2, ARX, CALB1, DCX, EMX2

Publications for Neuronal Migration Disorders

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Articles related to Neuronal Migration Disorders:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Genotype-phenotype correlation in neuronal migration disorders and cortical dysplasias. (26052266)
2015
2
Neuronal migration disorders: Focus on the cytoskeleton and epilepsy. (26299390)
2015
3
Rufinamide for the treatment of refractory epilepsy secondary to neuronal migration disorders. (24548548)
2014
4
The Relevance of Human Fetal Subplate Zone for Developmental Neuropathology of Neuronal Migration Disorders and Cortical Dysplasia. (25312583)
2014
5
Cytoskeleton in action: lissencephaly, a neuronal migration disorder. (23495356)
2013
6
Embryonic disruption of the candidate dyslexia susceptibility gene homolog Kiaa0319-like results in neuronal migration disorders. (23831424)
2013
7
Neuronal migration disorders. (19245832)
2010
8
The beta-tubulin gene TUBB2B is involved in a large spectrum of neuronal migration disorders. (20101787)
2010
9
Experimental neuronal migration disorders following the administration of ibotenate in hamsters: the role of the subventricular zone in the development of cortical dysplasia. (19258286)
2009
10
Neuronal migration disorders: clinical, neuroradiologic and genetics aspects. (19120042)
2009
11
Sudden death in a patient with mosaic ring X Turner syndrome and a neuronal migration disorder. (18049086)
2008
12
Neuronal migration disorders, agenesis of corpus callosum, preauricular skin tag and bilateral morning glory syndrome in a term newborn infant. (18388784)
2008
13
N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. (17875668)
2007
14
Reading impairment in the neuronal migration disorder of periventricular nodular heterotopia. (16434687)
2006
15
Neuronal migration disorders, genetics, and epileptogenesis. (15921228)
2005
16
Neurophysiologic findings of neuronal migration disorders: intrinsic epileptogenicity of focal cortical dysplasia on electroencephalography, electrocorticography, and magnetoencephalography. (15921239)
2005
17
Are altered excitatory synapses found in neuronal migration disorders? (16175215)
2005
18
Reading impairment in the neuronal migration disorder of periventricular nodular heterotopia. (15753412)
2005
19
Radial and tangential neuronal migration disorder in ibotenate-induced cortical lesions in hamsters: immunohistochemical study of reelin, vimentin, and calretinin. (15072103)
2004
20
Evidence of neuronal migration disorders in Knobloch syndrome: clinical and molecular analysis of two novel families. (12707952)
2003
21
MRI and EEG findings in surgically treated patients with partial seizures due to neuronal migration disorders, their relations to each other and to surgery outcome. (14616299)
2003
22
Various findings in surgically treated epilepsy patients with dysembryoplastic neuroepithelial tumors in comparison with those of patients with other low-grade brain tumors and other neuronal migration disorders. (12423388)
2002
23
Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker-Warburg syndrome. (12369018)
2002
24
Pathogenic significance of neuronal migration disorders in temporal lobe epilepsy. (11431720)
2001
25
Neuronal migration disorders. (11553932)
2001
26
Development and developmental disorders of the human brain. III. Neuronal migration disorders of the cerebrum]. (11268908)
2001
27
Immunohistochemical expression of doublecortin in the human cerebrum: comparison of normal development and neuronal migration disorders. (10773210)
2000
28
Single cause, polymorphic neuronal migration disorders: an animal model. (11085292)
2000
29
Neuronal migration disorders: from genetic diseases to developmental mechanisms. (10906798)
2000
30
Electrophysiological responses in vivo of hippocampal CA1 pyramidal neurons in an animal model of neuronal migration disorders. (10575261)
1999
31
The right neuron at the wrong place: biology of heterotopic neurons in cortical neuronal migration disorders, with special reference to associated pathologies. (10487203)
1999
32
Neuronal migration disorders in humans and in mouse models--an overview. (10515161)
1999
33
Characterization of neuronal migration disorders in neocortical structures: extracellular in vitro recordings. (9786203)
1998
34
Familial neuronal migration disorder: subcortical laminar heterotopia in a mother and pachygyria in the son. (9489790)
1998
35
Characterization of neuronal migration disorders in neocortical structures: quantitative receptor autoradiography of ionotropic glutamate, GABA(A) and GABA(B) receptors. (9786204)
1998
36
Neuronal migration disorders. Part I: Terminology, classification, pathophysiology, EEG and epilepsy. (10028855)
1998
37
Evidence of enhanced kindling and hippocampal neuronal injury in immature rats with neuronal migration disorders. (9860059)
1998
38
Neuronal migration disorders. Part II: Magnetic resonance imaging. (10028856)
1998
39
Congenital muscular dystrophy, white-matter abnormalities, and neuronal migration disorders: the expanding concept. (9796753)
1998
40
Positive epileptiform discharges in children with neuronal migration disorders. (9044397)
1997
41
Increased seizure susceptibility in adult rats with neuronal migration disorders. (9449431)
1997
42
Neuronal migration disorders presenting with mild clinical symptoms. (8703229)
1996
43
Characterization of neuronal migration disorders in neocortical structures: I. Expression of epileptiform activity in an animal model. (8985688)
1996
44
Neuronal migration disorders and epilepsy: a morphological analysis of three surgically treated patients. (8985686)
1996
45
Neuronal migration disorders. (7501186)
1995
46
Posterior agyria-pachygyria with polymicrogyria: evidence for an inherited neuronal migration disorder. (7824106)
1995
47
Electrophysiology of CA1 pyramidal neurons in an animal model of neuronal migration disorders: prenatal methylazoxymethanol treatment. (8777901)
1995
48
Prenatal events and genetic factors in epileptic patients with neuronal migration disorders. (7925168)
1994
49
Neuronal migration disorders: positron emission tomography correlations. (8122881)
1994
50
Stages and patterns of centrifugal arrest of diffuse neuronal migration disorders. (8335148)
1993

Variations for Neuronal Migration Disorders

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Clinvar genetic disease variations for Neuronal Migration Disorders:

5
id Gene Variation Type Significance SNP ID Assembly Location
1TUBA1ANM_006009.3(TUBA1A): c.1148C> T (p.Ala383Val)single nucleotide variantLikely pathogenic, Pathogenicrs587784482GRCh37Chr 12, 49579001: 49579001

Expression for genes affiliated with Neuronal Migration Disorders

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Search GEO for disease gene expression data for Neuronal Migration Disorders.

Pathways for genes affiliated with Neuronal Migration Disorders

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Pathways related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7NES, TUBA1A, VIM
29.2DCX, FLNA, PAFAH1B1, TUBA1A, VIM
39.2CALB1, DCX, MAP2, PAFAH1B1
49.1MAP1B, PAFAH1B1, RELN, VLDLR
58.5DCX, MAP1B, PAFAH1B1, RELN, VLDLR, YWHAE

GO Terms for genes affiliated with Neuronal Migration Disorders

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Cellular components related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1microtubule associated complexGO:00058759.9DCX, MAP1B, MAP2, PAFAH1B1
2dendriteGO:00304259.6CALB1, DCX, MAP2, RELN
3microtubuleGO:00058749.3DCX, MAP1B, MAP2, TUBA1A
4neuron projectionGO:00430059.1CALB1, DCX, MAP2, PAFAH1B1, VIM
5axonGO:00304248.7CALB1, PAFAH1B1, PVALB, YWHAE
6neuronal cell bodyGO:00430258.3CALB1, FLNA, MAP2, PAFAH1B1, PVALB
7cytosolGO:00058296.6ARFGEF2, CALB1, DCX, FLNA, MAP1B, PAFAH1B1

Biological processes related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1cerebral cortex tangential migrationGO:002180010.6ARX, RELN
2positive regulation of dendritic spine morphogenesisGO:006100310.5PAFAH1B1, RELN
3cell proliferation in forebrainGO:002184610.5ARX, EMX2
4cerebral cortex regionalizationGO:002179610.4ADGRG1, EMX2
5ventral spinal cord developmentGO:002151710.4RELN, VLDLR
6reelin-mediated signaling pathwayGO:003802610.4RELN, VLDLR
7positive regulation of neural precursor cell proliferationGO:200017910.3ADGRG1, NES
8axon extensionGO:004867510.2DCX, MAP1B
9microtubule bundle formationGO:000157810.1MAP1B, MAP2
10layer formation in cerebral cortexGO:002181910.0ADGRG1, PAFAH1B1, RELN
11long-term memoryGO:000761610.0CALB1, RELN
12hippocampus developmentGO:00217669.9PAFAH1B1, RELN, YWHAE
13forebrain developmentGO:00309009.9ARX, EMX2, RELN
14microtubule cytoskeleton organizationGO:00002269.9MAP1B, MAP2, PAFAH1B1
15dendrite developmentGO:00163589.8MAP1B, MAP2, RELN
16G2/M transition of mitotic cell cycleGO:00000869.7NES, PAFAH1B1, TUBA1A, YWHAE
17dendrite morphogenesisGO:00488139.7DCX, MAP2, VLDLR
18central nervous system developmentGO:00074179.6DCX, NES, RELN
19neuron migrationGO:00017649.5ARX, DCX, PAFAH1B1, RELN, YWHAE
20nervous system developmentGO:00073999.0DCX, MAP1B, NES, VLDLR
21brain developmentGO:00074208.8ADGRG1, DCX, EMX2, NES, PAFAH1B1, RELN
22cerebral cortex developmentGO:00219878.7EMX2, PAFAH1B1, RELN, VLDLR, YWHAE

Molecular functions related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:00019489.6FLNA, VIM, VLDLR
2microtubule bindingGO:00080179.2DCX, MAP1B, MAP2, PAFAH1B1
3structural molecule activityGO:00051988.9MAP1B, MAP2, NES, TUBA1A, VIM

Sources for Neuronal Migration Disorders

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet