MCID: NRN016
MIFTS: 42

Neuronal Migration Disorders malady

Category: Neuronal diseases

Aliases & Classifications for Neuronal Migration Disorders

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Aliases & Descriptions for Neuronal Migration Disorders:

Name: Neuronal Migration Disorders 49 27
 
Malformations of Cortical Development, Group Ii 68

Classifications:



Summaries for Neuronal Migration Disorders

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NINDS:49 Neuronal migration disorders (NMDs) are a group of birth defects caused by the abnormal migration of neurons in the developing brain and nervous system. In the developing brain, neurons must migrate from the areas where they are born to the areas where they will settle into their proper neural circuits. Neuronal migration, which occurs as early as the second month of gestation, is controlled by a complex assortment of chemical guides and signals. When these signals are absent or incorrect, neurons do not end up where they belong. This can result in structurally abnormal or missing areas of the brain in the cerebral hemispheres, cerebellum, brainstem, or hippocampus. The structural abnormalities found in NMDs include schizencephaly, porencephaly, lissencephaly, agyria, macrogyria, polymicrogyria, pachygyria, microgyria, micropolygyria, neuronal heterotopias (including band heterotopia), agenesis of the corpus callosum, and agenesis of the cranial nerves. Symptoms vary according to the abnormality, but often feature poor muscle tone and motor function, seizures, developmental delays, impaired cognitive development, failure to grow and thrive, difficulties with feeding, swelling in the extremities, and a smaller than normal head. Most infants with an NMD appear normal, but some disorders have characteristic facial or skull features that can be recognized by a neurologist. Several genetic abnormalities in children with NMDs have been identified. Defects in genes that are involved in neuronal migration have been associated with NMDs, but the role they play in the development of these disorders is not yet well-understood. More than 25 syndromes resulting from abnormal neuronal migration have been described. Among them are syndromes with several different patterns of inheritance; genetic counseling thus differs greatly between syndromes.

MalaCards based summary: Neuronal Migration Disorders, also known as malformations of cortical development, group ii, is related to lissencephaly 1 and pachygyria with mental retardation, seizures, and arachnoid cysts. An important gene associated with Neuronal Migration Disorders is DCX (Doublecortin), and among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include brain, cerebellum and cortex, and related mouse phenotypes are growth/size/body region and reproductive system.

Wikipedia:71 Neuronal migration disorder (NMD) refers to a heterogenous group of disorders that, it is supposed,... more...

Related Diseases for Neuronal Migration Disorders

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Diseases related to Neuronal Migration Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1lissencephaly 110.8
2pachygyria with mental retardation, seizures, and arachnoid cysts10.8
3flna-related periventricular nodular heterotopia10.8
4colpocephaly10.8
5neuronitis10.6
6deafness and hereditary hearing loss10.3DCX, PAFAH1B1
7noonan syndrome 1010.3DCX, PAFAH1B1
8meier-gorlin syndrome 610.3DCX, PAFAH1B1
9kcne2-related familial atrial fibrillation10.3DCX, PAFAH1B1, RELN
10autosomal recessive stickler syndrome10.3MAP2, VIM
11mental retardation, x-linked, syndromic 1510.2ARX, DCX, PAFAH1B1
12epithelial and subepithelial dystrophy10.2PAFAH1B1, YWHAE
13acoustic neuroma10.2ARFGEF2, EMX2
14superficial spreading melanoma10.2DCX, PAFAH1B1
15calcific tendinitis10.2MAP2, NES, VIM
16right ventricular hypoplasia, isolated10.2DCX, PAFAH1B1, YWHAE
17central nervous system hemangioma10.2MAP2, NES, VIM
18adenofibroma10.2MAP2, NES
19epilepsy10.1
20rete ovarii neoplasm10.1NES, YWHAE
21nephrogenic adenoma of urinary bladder10.1NES, VIM
22lung agenesis10.1DCX, PAFAH1B1, RELN, VLDLR
23palmoplantar keratoderma-sclerodactyly syndrome10.1DCX, PAFAH1B1, RELN, TUBA1A
24vulvar benign neoplasm10.1MAP2, NES
25amyotrophic lateral sclerosis 1810.0PAFAH1B1, TUBA1A, YWHAE
26fibrous dysplasia9.9DCX, FLNA, PAFAH1B1, TUBA1A
27cancerophobia9.9CALB1, PVALB
28cerebritis9.8
29thalassemia9.8CALB1, PVALB, RELN
30aids - neurological complications9.8ARX, DCX, PAFAH1B1, RELN, TUBA1A, VLDLR
31ck syndrome9.8FLNA, PAFAH1B1, PVALB, YWHAE
32pulmonary hypertension9.8ARFGEF2, ARX, FLNA, PVALB
33zellweger syndrome9.8
34muscular dystrophy9.8
35pachygyria9.8
36angiodysplasia9.7ARFGEF2, ARX, DCX, FLNA, PAFAH1B1, RELN
37loeys-dietz syndrome9.6ARX, DCX, PAFAH1B1, RELN, TUBA1A, VLDLR
38microcephalic osteodysplastic primordial dwarfism, type i9.6
39cerebral palsy9.6
40holoprosencephaly9.6
41temporal lobe epilepsy9.6
42lissencephaly9.6
43walker-warburg syndrome9.6
44pseudobulbar palsy9.6
45dysembryoplastic neuroepithelial tumor9.6
46turner syndrome9.6
47dyslexia9.6
48skin tag9.6
49diabetes insipidus9.6
50polymicrogyria9.6

Graphical network of the top 20 diseases related to Neuronal Migration Disorders:



Diseases related to neuronal migration disorders

Symptoms & Phenotypes for Neuronal Migration Disorders

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MGI Mouse Phenotypes related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.1ARFGEF2, ARX, DCX, EMX2, FLNA, MAP1B
2MP:00053897.8ARX, DCX, EMX2, FLNA, MAP1B, MAP2
3MP:00107687.5ARFGEF2, ARX, DCX, EMX2, FLNA, MAP1B
4MP:00053847.0ADGRG1, ARFGEF2, ARX, EMX2, FLNA, MAP1B
5MP:00053866.5ADGRG1, ARX, CALB1, DCX, EMX2, FLNA
6MP:00036315.8ADGRG1, ARFGEF2, ARX, CALB1, DCX, EMX2

Drugs & Therapeutics for Neuronal Migration Disorders

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Drugs for Neuronal Migration Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DopamineapprovedPhase 4383651-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
2
LevodopaapprovedPhase 440259-92-76047
Synonyms:
(-)-(3,4-Dihydroxyphenyl)alanine
(-)-3-(3,4-Dihydroxyphenyl)-L-alanine
(-)-3-(3,4-dihydroxyphenyl)-L-alanine
(-)-Dopa
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid
(−)-3-(3,4-dihydroxyphenyl)-L-alanine
(−)-dopa
.Beta.-(3, 4-Dihydroxyphenyl)alanine
.Beta.-(3,4-Dihydroxyphenyl)-L-alanine
1E83F927-C221-46AA-B90A-81B33C5F3868
2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid
23734-74-9
25525-15-9
3, 4-Dihydroxy-L-phenylalanine
3, 4-Dihydroxyphenylalanine
3,4-DIHYDROXYPHENYLALANINE
3,4-Dihydroxy-L-phenylalanine
3,4-Dihydroxyphenyl-L-alanine
3,4-Dihydroxyphenylalanine
3,4-Dihydroxyphenylalanine (VAN)
3,4-dihydroxy-L-phenylalanine
3,4-dihydroxyphenylalanine
3-(3,4-Dihydroxypheny
3-(3,4-Dihydroxyphenyl)-L-alanine
3-Hydroxy-L-tyrosine
34241-25-3
37830_FLUKA
587-45-1
59-92-7
72572-99-7
72573-00-3
88250-23-1
90638-38-3
AC-11686
AC1L1LOR
AC1Q4U7F
BIDD:GT0158
BPBio1_000059
BSPBio_000053
BSPBio_002354
Bendopa
Bio-0575
Biodopa
Brocadopa
C00355
C9H11NO4
CAS-59-92-7
CCRIS 3766
CHEBI:15765
CHEMBL1009
CID6047
Cerepap
Cidandopa
D 9628
D00059
D0600
D9628
D9628_SIGMA
DAH
DB01235
DOPA
Deadopa
Dihydroxy-L-phenylalanine
Dihydroxyphenylalanine
DivK1c_000452
Dopa
Dopaflex
Dopaidan
Dopal
Dopal-Fher
Dopal-fher
Dopalina
Dopar
Dopar (TN)
Doparkine
Doparl
Dopasol
Dopaston
Dopaston SE
Dopastone
Dopastral
Dopicar
Doprin
EINECS 200-445-2
EU-0100454
Eldopal
Eldopar
Eldopatec
Eurodopa
HMS1568C15
HMS1922J14
HMS2090O08
HMS2093N04
HMS501G14
HSDB 3348
Helfo DOPA
 
Helfo-Dopa
Helfo-dopa
IDI1_000452
IV Levodopa
InChI=1/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14
Insulamina
KBio1_000452
KBio2_000934
KBio2_003502
KBio2_006070
KBioGR_001177
KBioSS_000934
L Dopa
L(-)-Dopa
L-(-)-Dopa
L-(3, 4-Dihydroxyphenyl)-.alpha.-alani
L-(3, 4-Dihydroxyphenyl)alanine
L-(o-Dihydroxyphenyl)alanine
L-.Beta.-(3,4-Dihydroxyphenyl)alanine
L-3,4-Dihydroxyphenylalanine
L-3,4-dihydroxyphenylalanine
L-3-(3,4-Dihydroxyphenyl)-Alanine
L-3-(3,4-Dihydroxyphenyl)alanine
L-3-Hydroxytyrosine
L-4-5-Dihydroxyphenylalanine
L-DOPA
L-DOPA, Parcopa, Atamet, Stalevo, Madopar, Prolopa, Dopar, 3,4-Dihydroxyphenylalanine, Levodopa
L-Dihydroxyphenylalanine
L-Dopa
L-O-Dihydroxyphenylalanine
L-b-(3,4-Dihydroxyphenyl)-a-alanine
L-beta-(3,4-Dihydroxyphenyl)-alpha-alanine
L-beta-(3,4-Dihydroxyphenyl)alanine
L-o-Hydroxytyrosine
LS-255
Laradopa
Larodopa
Ledopa
Levedopa
Levodopa
Levodopa (JP15/USP)
Levodopa (JP15/USP/INN)
Levodopa [USAN:INN:BAN:JAN]
Levodopum
Levodopum [INN-Latin]
Levopa
Lopac-D-9628
Lopac0_000454
MLS000028514
Maipedopa
MolPort-000-856-937
NCGC00015384-01
NCGC00016270-01
NCGC00016270-06
NCGC00093869-04
NINDS_000452
NSC 118381
NSC118381
PDSP1_001541
PDSP2_001525
Parda
Pardopa
Prestwick0_000017
Prestwick1_000017
Prestwick2_000017
Prestwick3_000017
Prestwick_185
Prodopa
Ro 4-6316
S1726_Selleck
SDCCGMLS-0066924.P001
SMR000058312
SPBio_000391
SPBio_001974
SPECTRUM2300205
Sobiodopa
Spectrum2_000496
Spectrum4_000539
Spectrum5_001899
Spectrum_000454
Syndopa
UNII-46627O600J
Veldopa
Weldopa
b-(3,4-Dihydroxyphenyl)-L-alanine
b-(3,4-Dihydroxyphenyl)-a-L-alanine
b-(3,4-Dihydroxyphenyl)alanine
beta-(3,4-Dihydroxyphenyl)-L-alanine
beta-(3,4-Dihydroxyphenyl)-alpha-L-alanine
beta-(3,4-Dihydroxyphenyl)-alpha-alanine
beta-(3,4-Dihydroxyphenyl)alanine
bmse000322
component of Sinemet
l)-L-alanine
nchembio.2007.55-comp26
nchembio.89-comp9
ne
β-(3,4-dihydroxyphenyl)alanine
3Neurotransmitter AgentsPhase 418340
4Autonomic AgentsPhase 410150
5Protective AgentsPhase 47443
6Peripheral Nervous System AgentsPhase 423689
7Carbidopa, levodopa drug combinationPhase 4124
8DihydroxyphenylalaninePhase 4143
9Dopamine AgentsPhase 43836
10Omega 3 Fatty AcidNutraceuticalPhase 41018
11OliveNutraceuticalPhase 4278
12Serine Proteinase Inhibitors878
13
protease inhibitors5471
Synonyms:
 
protease inhibitors
14Neuroserpin3
15HIV Protease Inhibitors5470
16serineNutraceutical954

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled StudyUnknown statusNCT01361373Phase 4
2Omega-3 Fatty Acids Efficacy in First-episode of SchizophreniaUnknown statusNCT02210962Phase 4
3Mesenchymal Stem Cells for the Treatment of MSUnknown statusNCT00781872Phase 1, Phase 2
4Human Epilepsy Genetics--Neuronal Migration Disorders StudyRecruitingNCT00041600
5Investigation of Neuroserpin as an Autism Candidate GeneTerminatedNCT00917683

Search NIH Clinical Center for Neuronal Migration Disorders

Genetic Tests for Neuronal Migration Disorders

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Genetic tests related to Neuronal Migration Disorders:

id Genetic test Affiliating Genes
1 Abnormality of Neuronal Migration27

Anatomical Context for Neuronal Migration Disorders

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MalaCards organs/tissues related to Neuronal Migration Disorders:

36
Brain, Cerebellum, Cortex, Temporal lobe, Skin

Publications for Neuronal Migration Disorders

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Articles related to Neuronal Migration Disorders:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Genotype-phenotype correlation in neuronal migration disorders and cortical dysplasias. (26052266)
2015
2
Neuronal migration disorders: Focus on the cytoskeleton and epilepsy. (26299390)
2015
3
Rufinamide for the treatment of refractory epilepsy secondary to neuronal migration disorders. (24548548)
2014
4
The Relevance of Human Fetal Subplate Zone for Developmental Neuropathology of Neuronal Migration Disorders and Cortical Dysplasia. (25312583)
2014
5
Cytoskeleton in action: lissencephaly, a neuronal migration disorder. (23495356)
2013
6
Embryonic disruption of the candidate dyslexia susceptibility gene homolog Kiaa0319-like results in neuronal migration disorders. (23831424)
2013
7
Molecular genetics of neuronal migration disorders. (21222180)
2011
8
Neuronal migration disorders in microcephalic osteodysplastic primordial dwarfism type I/III. (20857301)
2011
9
New trends in neuronal migration disorders. (19264520)
2010
10
Neuronal migration disorders. (19245832)
2010
11
The beta-tubulin gene TUBB2B is involved in a large spectrum of neuronal migration disorders. (20101787)
2010
12
Experimental neuronal migration disorders following the administration of ibotenate in hamsters: the role of the subventricular zone in the development of cortical dysplasia. (19258286)
2009
13
Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder. (19098909)
2009
14
Neuronal migration disorders: clinical, neuroradiologic and genetics aspects. (19120042)
2009
15
Movement disorder and neuronal migration disorder due to ARFGEF2 mutation. (19384555)
2009
16
Neuronal migration disorders, agenesis of corpus callosum, preauricular skin tag and bilateral morning glory syndrome in a term newborn infant. (18388784)
2008
17
Sudden death in a patient with mosaic ring X Turner syndrome and a neuronal migration disorder. (18049086)
2008
18
N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. (17875668)
2007
19
Reading impairment in the neuronal migration disorder of periventricular nodular heterotopia. (16434687)
2006
20
Grey matter heterotopia: what EEG-fMRI can tell us about epileptogenicity of neuronal migration disorders. (16339793)
2006
21
Reading impairment in the neuronal migration disorder of periventricular nodular heterotopia. (15753412)
2005
22
Neurophysiologic findings of neuronal migration disorders: intrinsic epileptogenicity of focal cortical dysplasia on electroencephalography, electrocorticography, and magnetoencephalography. (15921239)
2005
23
Proceedings of the International Symposium on Neuronal Migration Disorders and Childhood Epilepsies: clinical manifestations, pathomechanisms, and etiopathogenesis. April 16-17, 2004. Tokyo, Japan. (16044620)
2005
24
Are altered excitatory synapses found in neuronal migration disorders? (16175215)
2005
25
Neuronal migration disorders. (16417844)
2005
26
Neuronal migration disorders, genetics, and epileptogenesis. (15921228)
2005
27
High molecular weight microtubule-associated protein 2 over-expression in neuronal migration disorders caused by N-methyl-D-aspartate receptor activation in hamsters. (15008898)
2004
28
Radial and tangential neuronal migration disorder in ibotenate-induced cortical lesions in hamsters: immunohistochemical study of reelin, vimentin, and calretinin. (15072103)
2004
29
Upregulation of glutamate receptors in rat cerebral cortex with neuronal migration disorders. (15201510)
2004
30
Evidence of neuronal migration disorders in Knobloch syndrome: clinical and molecular analysis of two novel families. (12707952)
2003
31
MRI and EEG findings in surgically treated patients with partial seizures due to neuronal migration disorders, their relations to each other and to surgery outcome. (14616299)
2003
32
Presumptive monosomy 21 with neuronal migration disorder re-diagnosed as de novo unbalanced translocation t(18p;21q) by fluorescence in situ hybridisation. (12150215)
2002
33
Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker-Warburg syndrome. (12369018)
2002
34
Various findings in surgically treated epilepsy patients with dysembryoplastic neuroepithelial tumors in comparison with those of patients with other low-grade brain tumors and other neuronal migration disorders. (12423388)
2002
35
Neuronal migration disorders. (11553932)
2001
36
Development and developmental disorders of the human brain. III. Neuronal migration disorders of the cerebrum]. (11268908)
2001
37
Lactate and other metabolic changes in neuronal migration disorders. (11240607)
2001
38
Molecular mechanisms of neuronal migration disorders, quo vadis? (11899256)
2001
39
Pathogenic significance of neuronal migration disorders in temporal lobe epilepsy. (11431720)
2001
40
Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. (11709191)
2001
41
Characterization of neuronal migration disorders in neocortical structures: loss or preservation of inhibitory interneurons? (10897147)
2000
42
Neuronal migration disorders in man. (11151046)
2000
43
Immunohistochemical expression of doublecortin in the human cerebrum: comparison of normal development and neuronal migration disorders. (10773210)
2000
44
Single cause, polymorphic neuronal migration disorders: an animal model. (11085292)
2000
45
A novel migration-related gene product, doublecortin, in neuronal migration disorder of fetuses and infants with Zellweger syndrome. (10963364)
2000
46
Neuronal migration disorders: from genetic diseases to developmental mechanisms. (10906798)
2000
47
The right neuron at the wrong place: biology of heterotopic neurons in cortical neuronal migration disorders, with special reference to associated pathologies. (10487203)
1999
48
Electrophysiological responses in vivo of hippocampal CA1 pyramidal neurons in an animal model of neuronal migration disorders. (10575261)
1999
49
Neuronal migration disorders in cerebral palsy. (19519643)
1999
50
Metabolic changes in neuronal migration disorders: evaluation by combined MRI and proton MR spectroscopy. (10403210)
1999

Variations for Neuronal Migration Disorders

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Expression for genes affiliated with Neuronal Migration Disorders

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Search GEO for disease gene expression data for Neuronal Migration Disorders.

Pathways for genes affiliated with Neuronal Migration Disorders

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GO Terms for genes affiliated with Neuronal Migration Disorders

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Cellular components related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1central region of growth coneGO:009072410.7PAFAH1B1, YWHAE
2microtubule associated complexGO:000587510.2DCX, MAP1B, MAP2, PAFAH1B1
3dendritic spineGO:004319710.0ARFGEF2, CALB1, MAP1B
4dendriteGO:00304259.8ARFGEF2, CALB1, MAP2, RELN
5microtubuleGO:00058749.8DCX, MAP1B, MAP2, PAFAH1B1, TUBA1A
6neuron projectionGO:00430059.6CALB1, DCX, MAP2, PAFAH1B1, VIM
7axonGO:00304249.6CALB1, PAFAH1B1, PVALB, YWHAE
8cytoskeletonGO:00058568.9ARFGEF2, DCX, FLNA, MAP1B, MAP2, PAFAH1B1
9neuronal cell bodyGO:00430258.5CALB1, FLNA, MAP2, PAFAH1B1, PVALB
10cytoplasmGO:00057377.0ARFGEF2, CALB1, DCX, FLNA, MAP1B, MAP2

Biological processes related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1axon extensionGO:004867510.7DCX, MAP1B
2cerebral cortex tangential migrationGO:002180010.7ARX, RELN
3cell proliferation in forebrainGO:002184610.7ARX, EMX2
4central nervous system developmentGO:000741710.6DCX, NES, RELN
5positive regulation of dendritic spine morphogenesisGO:006100310.5PAFAH1B1, RELN
6forebrain developmentGO:003090010.5ARX, EMX2, RELN
7cerebral cortex regionalizationGO:002179610.5ADGRG1, EMX2
8dendrite morphogenesisGO:004881310.4DCX, MAP2, VLDLR
9reelin-mediated signaling pathwayGO:003802610.3RELN, VLDLR
10hippocampus developmentGO:002176610.3DCX, PAFAH1B1, RELN, YWHAE
11ciliary basal body dockingGO:009771110.2PAFAH1B1, TUBA1A, YWHAE
12layer formation in cerebral cortexGO:002181910.1ADGRG1, DCX, PAFAH1B1, RELN
13G2/M transition of mitotic cell cycleGO:000008610.0NES, PAFAH1B1, TUBA1A, YWHAE
14ventral spinal cord developmentGO:00215179.9RELN, VLDLR
15cerebral cortex developmentGO:00219879.8EMX2, FLNA, PAFAH1B1, RELN, YWHAE
16positive regulation of neural precursor cell proliferationGO:20001799.7ADGRG1, FLNA, NES
17brain developmentGO:00074209.6ADGRG1, DCX, EMX2, NES, PAFAH1B1, RELN
18neuron migrationGO:00017649.4ARX, DCX, KIAA0319, PAFAH1B1, RELN, YWHAE
19regulation of cytosolic calcium ion concentrationGO:00514809.1CALB1, PVALB, YWHAE
20multicellular organism developmentGO:00072758.9ADGRG1, ARX, DCX, EMX2, KIAA0319, NES
21nervous system developmentGO:00073998.6ADGRG1, ARX, DCX, KIAA0319, MAP1B, NES

Molecular functions related to Neuronal Migration Disorders according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1microtubule bindingGO:000801710.1DCX, MAP1B, MAP2, PAFAH1B1
2glycoprotein bindingGO:000194810.1FLNA, VIM, VLDLR
3structural molecule activityGO:00051989.0MAP1B, MAP2, NES, TUBA1A, VIM

Sources for Neuronal Migration Disorders

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
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34KEGG
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63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet