MCID: NRN002
MIFTS: 64

Neuronitis malady

Neuronal diseases category

Summaries for Neuronitis

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32MalaCards
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MalaCards: Neuronitis is related to neuronal ceroid-lipofuscinoses and dementia. An important gene associated with Neuronitis is NOS1AP (nitric oxide synthase 1 (neuronal) adaptor protein), and among its related pathways are Transmission across Chemical Synapses and Circadian entrainment. The compounds glutamate and galantamine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Neuronitis

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8Disease Ontology, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuronitis 8 60


External Ids:

Disease Ontology8 DOID:8117
NCIt39 C34847

Related Diseases for Neuronitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Neuronitis:



Diseases related to neuronitis

Clinical Features for Neuronitis

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Drugs & Therapeutics for Neuronitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neuronitis

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Anatomical Context for Neuronitis

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32MalaCards
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MalaCards organs/tissues related to Neuronitis:

32
Brain, Cortex, Spinal cord, Lung, Dorsal root ganglion, Hypothalamus, Pituitary, Endothelial, Bone, Retina, Colon, Prefrontal cortex, Temporal lobe, Amygdala, Cerebellum, Skin, Bone marrow, T cells, Small intestine, Heart, Testes, Eye, Monocytes, Ciliary ganglion, Olfactory bulb, Thyroid, Skeletal muscle, Prostate, Smooth muscle, Breast, Trigeminal ganglion, Fetal brain, Liver, Kidney, B cells, Cingulate cortex, Thalamus, Pancreas, Pons, Globus pallidus, Subthalamic nucleus, Trachea, Placenta, Salivary gland, Medulla oblongata, Adipocyte, Thymus, Caudate nucleus, Tongue, Testis, Pineal, Myeloid, Pancreatic islet, Adrenal gland, Ovary, Lymph node, Cervix, Parietal lobe, Cardiac myocytes

Animal Models for Neuronitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuronitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363114.0ENO2, APBA2, AP3B2, APBA1, NPTX2, NPTX1
2MP:000538613.5AP3B2, APBA1, NPTX2, NPTX1, NPAS1, CHRNB2

Publications for Neuronitis

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50PubMed
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Articles related to Neuronitis:

(show top 50)    (show all 15238)
idTitleAuthorsYear
1
Involvement of the mirror neuron system in blunted affect in schizophrenia. (24268934)
2014
2
Risk of cerebral embolism after interventional closure of symptomatic patent foramen ovale or atrial septal defect: a diffusion-weighted MRI and neuron-specific enolase-based study. (24088426)
2013
3
Basal Ganglia Neuronal Activity during Scanning Eye Movements in Parkinson's Disease. (24223158)
2013
4
Combined Transplantation of Human Neuronal and Mesenchymal Stem Cells following Spinal Cord Injury. (24436845)
2013
5
Neuronal pentraxin II (NPTX2) is frequently down-regulated by promoter hypermethylation in pancreatic cancers. (22806544)
2012
6
The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosis. (22031903)
2011
7
The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. (20876357)
2010
8
Ubiquitin-positive intranuclear inclusions in neuronal and glial cells in a mouse model of the fragile X premutation. (20051238)
2010
9
The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. (19413571)
2009
10
Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells. (19695092)
2009
11
Signaling pathways from cannabinoid receptor-1 activation to inhibition of N-methyl-D-aspartic acid mediated calcium influx and neurotoxicity in dorsal root ganglion neurons. (19752241)
2009
12
Phospholipid transfer protein reduces phosphorylation of tau in human neuronal cells. (19472218)
2009
13
A large population of diverse neurons in the Drosophila central nervous system expresses short neuropeptide F, suggesting multiple distributed peptide functions. (18803813)
2008
14
Retrovirus delivered neurotrophin-3 promotes survival, proliferation and neuronal differentiation of human fetal neural stem cells in vitro. (19875351)
2008
15
Laser scanning cytometry in the characterization of the proapoptotic effects of transiently transfected genes in cerebellar granule neurons. (16967493)
2006
16
Leptin and CCK selectively activate vagal afferent neurons innervating the stomach and duodenum. (16384857)
2006
17
Mitochondrial involvement in nitric oxide-induced cellular death in cortical neurons in culture. (16397899)
2006
18
Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease. (15160835)
2004
19
Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases. (15178948)
2004
20
Pituitary adenylate cyclase activating polypeptide (PACAP) decreases neuronal somatostatin immunoreactivity in cultured guinea-pig parasympathetic cardiac ganglia. (15207351)
2004
21
Effects of melanin and manganese on DNA damage and repair in PC12-derived neurons. (15082068)
2004
22
Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. (12716924)
2003
23
Phase resetting light pulses induce Per1 and persistent spike activity in a subpopulation of biological clock neurons. (12598633)
2003
24
The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2). (14697653)
2003
25
Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma. (11973648)
2002
26
Clinical features and molecular genetic basis of the neuronal ceroid lipofuscinoses. (11968447)
2002
27
Protein kinase C gamma (PKC gamma): function of neuron specific isotype. (12417016)
2002
28
15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis. (11277593)
2001
29
CRMP-2 induces axons in cultured hippocampal neurons. (11477421)
2001
30
Rapid loss of microvascular integrin expression during focal brain ischemia reflects neuron injury. (11435796)
2001
31
X-ray absorption spectroscopic analysis of the high-spin ferriheme site in substrate-bound neuronal nitric-oxide synthase. (11481035)
2001
32
RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III. (11234015)
2001
33
Neuronal correlates of amblyopia in the visual cortex of macaque monkeys with experimental strabismus and anisometropia, by L. Kiorpes, D. Kiper, L. O'Keefe, J. Cavanaugh, and A. Movshon. J neuroscience 18:6411-24, 1998. (11033044)
2000
34
Aminoguanidine-mediated inactivation and alteration of neuronal nitric-oxide synthase. (10788446)
2000
35
Stimulation of adenosine A3 receptors in cerebral ischemia. Neuronal death, recovery, or both? (10668416)
1999
36
p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. (9727024)
1998
37
Inhibition of p75 tumor necrosis factor receptor by antisense oligonucleotides increases hypoxic injury and beta-amyloid toxicity in human neuronal cell line. (9013604)
1997
38
Synaptic connections of calretinin-immunoreactive neurons in the human neocortex. (9185552)
1997
39
Pro-gastrin-releasing peptide (31-98) as a tumour marker of small-cell lung cancer: comparative evaluation with neuron-specific enolase. (8630283)
1996
40
Steroid imprinting and modulation of sexual dimorphism in the luteinizing hormone-releasing hormone neuronal system. (8743965)
1996
41
"Capsaicin-sensitive" sensory neurons in cluster headache: pathophysiological aspects and therapeutic indication. (7515383)
1994
42
Neurotrophic effects of cAMP generating systems on central noradrenergic neurons. (8102314)
1993
43
Electrophysiology of guinea-pig supraoptic neurones: role of a hyperpolarization-activated cation current in phasic firing. (8487202)
1993
44
Establishment of pure neuronal cultures from fetal rat spinal cord and proliferation of the neuronal precursor cells in the presence of fibroblast growth factor. (1724269)
1991
45
Alpha 2-macroglobulin synthesis in interleukin-6-stimulated human neuronal (SH-SY5Y neuroblastoma) cells. Potential significance for the processing of Alzheimer beta-amyloid precursor protein. (1709116)
1991
46
Dystrophin gene transcribed from different promoters in neuronal and glial cells. (2406613)
1990
47
An alert for motor neuron diseases and peripheral neuropathy: monoclonal paraproteinemia may be missed by routine electrophoresis. (3030245)
1987
48
Vestibular neuronitis: the experience at Harare Central Hospital, Zimbabwe: case report. (4076038)
1985
49
The neuronal ceroid lipofuscinoses in British Columbia: a clinical epidemiologic and ultrastructural study. (974252)
1976
50
Pigmentary retinal lipoid neuronal heredodegeneration (Spielmeyer-Vogt disease); the neuro-ophthalmologic considerations. (13339900)
1956

Genetic Variations for Neuronitis

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Expression for genes affiliated with Neuronitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuronitis

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Pathways for genes affiliated with Neuronitis

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53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Neuronitis

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Neuronitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glutamate4412.1ENO2, SLC1A1, CLN3, CHRNA7, NPTX1, NPTX2
2galantamine44 49 1113.8CHRNA6, CHRNA7, CHRNA2, CHRNB2
3nicotine44 49 28 1114.7CHRNA6, CHRNA7, CHRNA2, CHRNB2
4potassium44 11 2413.6ENO2, SLC1A1, CHRNB2, NPTX1
5mecamylamine28 44 1113.5CHRNA6, CHRNA7, CHRNA2
6ly2087101 2811.2CHRNA2, CHRNA7
7[3h]epibatidine2811.2CHRNA7, CHRNA2
8varenicline44 1112.1CHRNA7, CHRNA6
9nmda44 2812.0NOS1AP, SLC1A1, CHRNA7
10hexamethonium44 2811.9CHRNA2, CHRNA6

GO Terms for genes affiliated with Neuronitis

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16Gene Ontology
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Cellular components related to Neuronitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588612.9APBA2, APBA1, CHRNB2, CHRNA2, CHRNA7, CHRNA6
2acetylcholine-gated channel complexGO:00589211.6CHRNA6, CHRNA7, CHRNA2, CHRNB2
3cell junctionGO:03005411.6CHRNA6, CHRNA7, CHRNA2, CHRNB2
4postsynaptic membraneGO:04521111.5CHRNB2, CHRNA2, CHRNA7, CHRNA6

Biological processes related to Neuronitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726813.4SLC1A1, APBA2, APBA1, NPTX2, NPTX1, CHRNB2
2ion transportGO:00681111.8SLC1A1, CHRNA7, CHRNA2, CHRNB2
3locomotory behaviorGO:00762611.4APBA2, APBA1, CHRNB2
4central nervous system developmentGO:00741711.4PNMA1, NPAS1, NPTX1
5regulation of dopamine secretionGO:01405911.1CHRNA6, CHRNB2
6cognitionGO:05089011.0CHRNB2, CHRNA7
7response to nicotineGO:03509411.0CHRNA7, CHRNB2
8associative learningGO:00830610.9CLN3, CHRNB2
9membrane depolarizationGO:05189910.7CHRNA6, CHRNB2

Molecular functions related to Neuronitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine receptor activityGO:01546411.6CHRNA6, CHRNA7, CHRNA2, CHRNB2
2acetylcholine-activated cation-selective channel activityGO:00488911.5CHRNB2, CHRNA2, CHRNA7, CHRNA6
3acetylcholine bindingGO:04216611.0CHRNA7, CHRNB2
4beta-amyloid bindingGO:00154011.0CHRNA7, APBA1, APBA2

Products for genes affiliated with Neuronitis

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Sources for Neuronitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet