MCID: NRN002
MIFTS: 41

Neuronitis malady

Categories: Neuronal diseases

Aliases & Classifications for Neuronitis

Aliases & Descriptions for Neuronitis:

Name: Neuronitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8117
NCIt 47 C34847
UMLS 69 C0027881

Summaries for Neuronitis

Disease Ontology : 12 A central nervous system disease that is characterized by neuron inflammation.

MalaCards based summary : Neuronitis is related to stiff-person syndrome and ceroid lipofuscinosis, neuronal, 3. An important gene associated with Neuronitis is CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A), and among its related pathways/superpathways are Apoptosis and Autophagy and TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. The drugs Prednisolone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related phenotypes are cellular and hematopoietic system

Related Diseases for Neuronitis

Diseases related to Neuronitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1085)
id Related Disease Score Top Affiliating Genes
1 stiff-person syndrome 30.9 CD40LG TNFRSF10A
2 ceroid lipofuscinosis, neuronal, 3 12.3
3 motor neuron disease 12.3
4 neuronal ceroid lipofuscinosis 12.3
5 ceroid lipofuscinosis, neuronal, 1 12.2
6 ceroid lipofuscinosis, neuronal, 10 12.2
7 ceroid lipofuscinosis, neuronal, 5 12.2
8 ceroid lipofuscinosis, neuronal, 2 12.2
9 ceroid lipofuscinosis, neuronal, 6 12.2
10 ceroid lipofuscinosis, neuronal, 4, parry type 12.2
11 ceroid lipofuscinosis, neuronal, 7 12.2
12 ceroid lipofuscinosis, neuronal, 13, kufs type 12.2
13 ceroid lipofuscinosis, neuronal, 8, northern epilepsy variant 12.2
14 adult neuronal ceroid lipofuscinosis 12.1
15 ceroid lipofuscinosis, neuronal, 8 12.1
16 ceroid lipofuscinosis, neuronal, 11 12.1
17 vestibular neuronitis 12.1
18 neuronal intranuclear inclusion disease 12.1
19 madras motor neuron disease 12.1
20 ceroid lipofuscinosis, neuronal, kufs type, adult onset 12.1
21 neuronal migration disorders 12.1
22 ceroid lipofuscinosis, neuronal, 9 12.1
23 neuronal intestinal dysplasia 12.0
24 neuronal ceroid lipofuscinosis 4a 12.0
25 intestinal pseudoobstruction, neuronal 12.0
26 neuronal ceroid-lipofuscinoses 12.0
27 survival motor neuron spinal muscular atrophy 11.8
28 nodular neuronal heterotopia 11.7
29 amyotrophic lateral sclerosis 1 11.7
30 focal or multifocal malformations in neuronal migration 11.6
31 neuronal interstitial dysplasia 11.6
32 amyotrophic lateral sclerosis 4, juvenile 11.6
33 lateral sclerosis 11.6
34 pick disease 11.6
35 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 11.4
36 mitochondrial dna depletion syndrome 4a 11.3
37 dementia, frontotemporal 11.3
38 spinal muscular atrophy, distal, autosomal recessive, 4 11.3
39 spinal muscular atrophy 11.3
40 mental retardation, autosomal dominant 13 11.2
41 progressive muscular atrophy 11.2
42 epilepsy, progressive myoclonic 3, with or without intracellular inclusions 11.2
43 spastic paraplegia 39, autosomal recessive 11.2
44 neuropathy, distal hereditary motor, type viib 11.2
45 spinal muscular atrophy, jokela type 11.2
46 juvenile amyotrophic lateral sclerosis 11.1
47 primary lateral sclerosis, juvenile 11.1
48 kufor-rakeb syndrome 11.1
49 hereditary spastic paraplegia 11.1
50 niemann-pick disease 11.1

Graphical network of the top 20 diseases related to Neuronitis:



Diseases related to Neuronitis

Symptoms & Phenotypes for Neuronitis

MGI Mouse Phenotypes related to Neuronitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.26 MB TNFRSF10A CACNA1A CD40LG
2 hematopoietic system MP:0005397 8.92 CACNA1A CD40LG MB TNFRSF10A

Drugs & Therapeutics for Neuronitis

Drugs for Neuronitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4 Prednisolone acetate Phase 4,Phase 3
5 glucocorticoids Phase 4,Phase 3,Phase 2
6 Gastrointestinal Agents Phase 4,Phase 3
7 Neuroprotective Agents Phase 4,Phase 3
8 Hormone Antagonists Phase 4,Phase 3,Phase 2
9 Hormones Phase 4,Phase 3,Phase 2
10 Peripheral Nervous System Agents Phase 4,Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
12 Prednisolone hemisuccinate Phase 4,Phase 3
13 Prednisolone phosphate Phase 4,Phase 3
14 Protective Agents Phase 4,Phase 3
15 Antiemetics Phase 4,Phase 3
16 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
17 Methylprednisolone acetate Phase 4,Phase 3
18 Methylprednisolone Hemisuccinate Phase 4,Phase 3
19 Autonomic Agents Phase 4,Phase 3
20 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
21 Betamethasone Valerate Phase 4 2152-44-5
22 Anti-Asthmatic Agents Phase 4,Phase 3
23 Respiratory System Agents Phase 4,Phase 3
24 Betamethasone benzoate Phase 4
25 Betamethasone sodium phosphate Phase 4
26 Betamethasone-17,21-dipropionate Phase 4
27
Cilostazol Approved Phase 3 73963-72-1 2754
28 Vasodilator Agents Phase 3
29 Phosphodiesterase 3 Inhibitors Phase 3
30 Phosphodiesterase Inhibitors Phase 3
31 Platelet Aggregation Inhibitors Phase 3
32 Fibrinolytic Agents Phase 3
33 Bronchodilator Agents Phase 3
34 Ginkgo Nutraceutical Phase 3
35
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
36
Dexamethasone Approved, Investigational, Vet_approved Early Phase 1 50-02-2 5743
37
Menthol Approved Early Phase 1 2216-51-5 16666
38 Dexamethasone acetate Early Phase 1 1177-87-3
39 Dexamethasone 21-phosphate Early Phase 1
40 BB 1101 Early Phase 1

Interventional clinical trials:

(show all 12)
id Name Status NCT ID Phase
1 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Recruiting NCT02912182 Phase 4
2 The Efficacy of Steroid Therapy in Vestibular Neuritis Unknown status NCT02098330 Phase 3
3 Effect of Renexin Tablet in Patients With Recurrent Vestibulopathy Terminated NCT01895400 Phase 3
4 Prednisone Treatment for Vestibular Neuronitis Completed NCT00271791 Phase 2
5 Complementary/Alternative Medicine for Abnormality in the Vestibular (Balance) System Completed NCT00032383 Phase 1, Phase 2
6 Characterisation of Cortical Vestibular Evoked Potentials (C-VEPs) Unknown status NCT02463695
7 The Role of Corticosteroids and Vestibular Exercises in Recovery of Vestibular Neuritis Unknown status NCT01231009 Early Phase 1
8 Vestibular System in Migrainous Vertigo Patients Unknown status NCT00901953
9 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216
10 Home-based Computer Gaming in Vestibular Rehabilitation Completed NCT01943955
11 Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool Completed NCT02171312
12 Assessment and Treatment of Patients With Long-term Dizziness in Primary Care Recruiting NCT02655575

Search NIH Clinical Center for Neuronitis

Genetic Tests for Neuronitis

Anatomical Context for Neuronitis

MalaCards organs/tissues related to Neuronitis:

39
Brain, Cortex, Spinal Cord, Lung, Dorsal Root Ganglion, Hypothalamus, Endothelial

Publications for Neuronitis

Articles related to Neuronitis:

(show top 50) (show all 16854)
id Title Authors Year
1
Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. ( 27872486 )
2017
2
Neuronal nitric oxide synthase polymorphisms in obsessive-compulsive disorder. ( 27739347 )
2017
3
Homer1b/c clustering is impaired in Phelan-McDermid Syndrome iPSCs derived neurons. ( 28428614 )
2017
4
Fingolimod and Teriflunomide Attenuate Neurodegeneration in Mouse Models of Neuronal Ceroid Lipofuscinosis. ( 28506594 )
2017
5
Neurons Derived from Induced Pluripotent Stem Cells of Patients with Down Syndrome Reproduce Early Stages of Alzheimer's Disease Type Pathology in vitro. ( 28059787 )
2017
6
ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss. ( 28335020 )
2017
7
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis. ( 28404863 )
2017
8
Inhibition of DPP-4 Activity and Neuronal Atrophy with Genistein Attenuates Neurological Deficits Induced by Transient Global Cerebral Ischemia and Reperfusion in Streptozotocin-Induced Diabetic Mice. ( 28091829 )
2017
9
Cerebrospinal fluid high mobility group box 1 is associated with neuronal death in subarachnoid hemorrhage. ( 26823474 )
2017
10
in vivo localization of the neuronal ceroid lipofuscinosis proteins, CLN3 and CLN7, at endogenous expression levels. ( 28365214 )
2017
11
Extra-neuronal pathology in a canine model of CLN2 neuronal ceroid lipofuscinosis after intracerebroventricular gene therapy that delays neurological disease progression. ( 28079862 )
2017
12
Networks of Cultured iPSC-Derived Neurons Reveal the Human Synaptic Activity-Regulated Adaptive Gene Program. ( 28052243 )
2017
13
SFRP2 enhanced the adipogenic and neuronal differentiation potentials of stem cells from apical papilla. ( 28244619 )
2017
14
Proteomics insights into infantile neuronal ceroid lipofuscinosis (CLN1) point to the involvement of cilia pathology in the disease. ( 28334871 )
2017
15
Correlation of Ventricular Arrhythmogenesis with Neuronal Remodeling of Cardiac Postganglionic Parasympathetic Neurons in the Late Stage of Heart Failure after Myocardial Infarction. ( 28533740 )
2017
16
Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors. ( 28212375 )
2017
17
Motor neuron disease: Brain-computer interface unlocks the mind of a patient with ALS. ( 27909307 )
2017
18
Gemfibrozil, food and drug administration-approved lipid-lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis. ( 28199020 )
2017
19
The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking. ( 27940359 )
2017
20
Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy. ( 28426667 )
2017
21
Risk factors for respiratory failure of motor neuron disease in a multiracial Asian population. ( 28089419 )
2017
22
Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection. ( 27816995 )
2017
23
Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. ( 28175299 )
2017
24
Hereditary spastic paraplegia: More than an upper motor neuron disease. ( 28449883 )
2017
25
Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models. ( 28463115 )
2017
26
Voltage-Gated Potassium Channel Antibodies in Slow-Progression Motor Neuron Disease. ( 27710962 )
2017
27
Dataset in support of the generation of Niemann-Pick disease Type C1 patient-specific iPS cell lines carrying the novel NPC1 mutation c.1180T>C or the prevalent c.3182T>C mutation - Analysis of pluripotency and neuronal differentiation. ( 28413817 )
2017
28
Startle suppression after mild traumatic brain injury is associated with an increase in pro-inflammatory cytokines, reactive gliosis and neuronal loss in the caudal pontine reticular nucleus. ( 28089558 )
2017
29
Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease. ( 28072907 )
2017
30
Activation of KCNQ channels suppresses spontaneous activity in DRG neurons and reduces chronic pain after spinal cord injury. ( 28073317 )
2017
31
Early enteric neuron dysfunction in mouse and human HuntingtonA disease. ( 27836713 )
2017
32
Rapid neuroinflammatory response localized to injured neurons after diffuse traumatic brain injury in swine. ( 28081963 )
2017
33
Disrupted neuronal maturation in Angelman syndrome-derived induced pluripotent stem cells. ( 28436452 )
2017
34
Mechanism Governing Human Kappa-Opioid Receptor Expression under Desferrioxamine-Induced Hypoxic Mimic Condition in Neuronal NMB Cells. ( 28117678 )
2017
35
Perirhinal accumulation of neuronal alpha-synuclein in a multiple system atrophy patient with dementia. ( 28419566 )
2017
36
Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening. ( 28075486 )
2017
37
Serum antibodies targeting neurons of the monoaminergic systems in Guillain-BarrAc syndrome. ( 28017237 )
2017
38
MiR-29c/PRKCI Regulates Axonal Growth of Dorsal Root Ganglia Neurons Under Hyperglycemia. ( 28070856 )
2017
39
Motor neuron disease mortality and lifetime petrol lead exposure: Evidence from national age-specific and state-level age-standardized death rates in Australia. ( 27992849 )
2017
40
The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic I+4I^2 Receptors. ( 27895161 )
2017
41
Ginsenoside Rg3 Improves Recovery from Spinal Cord Injury in Rats via Suppression of Neuronal Apoptosis, Pro-Inflammatory Mediators, and Microglial Activation. ( 28085110 )
2017
42
Chronic Enzyme Replacement to the Brain of a Late Infantile Neuronal Ceroid Lipofuscinosis Mouse Has Differential Effects on Phenotypes of Disease. ( 28345005 )
2017
43
Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy. ( 28481536 )
2017
44
Motor neuronal repletion of the NMJ organizer, Agrin, modulates the severity of the spinal muscular atrophy disease phenotype in model mice. ( 28379354 )
2017
45
The death wish and motor neuron disease! The chameleons and new research optimism. ( 28084230 )
2017
46
Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy. ( 28504671 )
2017
47
Lycopene inhibits regulator of calcineurin 1-mediated apoptosis by reducing oxidative stress and down-regulating Nucling in neuronal cells. ( 27928873 )
2017
48
A proposal for new neurorehabilitative intervention on Moebius Syndrome patients after 'smile surgery'. Proof of concept based on mirror neuron system properties and hand-mouth synergistic activity. ( 28434583 )
2017
49
Mouse models of kufor-rakeb disease link Parkinson's disease closer to neuronal ceroid lipofuscinosis, suggesting lysosomal dysfunction as shared mechanism. ( 28071821 )
2017
50
A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis. ( 28127059 )
2017

Variations for Neuronitis

Expression for Neuronitis

Search GEO for disease gene expression data for Neuronitis.

Pathways for Neuronitis

Pathways related to Neuronitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.22 CD40LG TNFRSF10A
2
Show member pathways
10.55 CD40LG TNFRSF10A

GO Terms for Neuronitis

Biological processes related to Neuronitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 8.62 CD40LG TNFRSF10A

Sources for Neuronitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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