MCID: NRN002
MIFTS: 64

Neuronitis malady

Neuronal diseases category

Summaries for Neuronitis

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32MalaCards
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MalaCards: Neuronitis is related to neuronal ceroid-lipofuscinoses and dementia. An important gene associated with Neuronitis is NOS1AP (nitric oxide synthase 1 (neuronal) adaptor protein), and among its related pathways are Transmission across Chemical Synapses and Circadian entrainment. The compounds glutamate and galantamine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Neuronitis

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8Disease Ontology, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuronitis 8 60


External Ids:

Disease Ontology8 DOID:8117
NCIt39 C34847

Related Diseases for Neuronitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Neuronitis:



Diseases related to neuronitis

Clinical Features for Neuronitis

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Drugs & Therapeutics for Neuronitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neuronitis

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Anatomical Context for Neuronitis

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32MalaCards
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MalaCards organs/tissues related to Neuronitis:

32
Brain, Cortex, Spinal cord, Lung, Dorsal root ganglion, Hypothalamus, Pituitary, Endothelial, Bone, Retina, Colon, Prefrontal cortex, Temporal lobe, Amygdala, Cerebellum, Skin, Bone marrow, T cells, Small intestine, Heart, Testes, Eye, Monocytes, Ciliary ganglion, Olfactory bulb, Thyroid, Skeletal muscle, Prostate, Smooth muscle, Breast, Trigeminal ganglion, Fetal brain, Liver, Kidney, B cells, Cingulate cortex, Thalamus, Pancreas, Pons, Globus pallidus, Subthalamic nucleus, Trachea, Placenta, Salivary gland, Medulla oblongata, Adipocyte, Thymus, Caudate nucleus, Tongue, Testis, Pineal, Myeloid, Pancreatic islet, Adrenal gland, Ovary, Lymph node, Cervix, Parietal lobe, Cardiac myocytes

Animal Models for Neuronitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuronitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363114.0ENO2, APBA2, AP3B2, APBA1, NPTX2, NPTX1
2MP:000538613.5AP3B2, APBA1, NPTX2, NPTX1, NPAS1, CHRNB2

Publications for Neuronitis

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50PubMed
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Articles related to Neuronitis:

(show top 50)    (show all 15238)
idTitleAuthorsYear
1
The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. (24094650)
2013
2
A novel c.776_777insA mutation in CLN1 leads to infantile neuronal ceroid lipofuscinosis. (23857568)
2013
3
Genome-wide analysis points to roles for extracellular matrix remodeling, the visual cycle, and neuronal development in myopia. (23468642)
2013
4
Prevention of acute/severe hypoglycemia-induced neuron death by lactate administration. (22453629)
2012
5
Silencing of frataxin gene expression triggers p53-dependent apoptosis in human neuron-like cells. (21531789)
2011
6
A potassium channel opener for neuropathy, motor neuron disease and beyond. (22098919)
2011
7
Spatiotemporal distribution of tenascin-R in the developing human cerebral cortex parallels neuronal migration. (21456020)
2011
8
Ethanol-induced neurodegeneration in NRSF/REST neuronal conditional knockout mice. (21396985)
2011
9
Relation among neuronal death, cell proliferation and neuronal differentiation in the gerbil main olfactory bulb after transient cerebral ischemia. (20405201)
2010
10
Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells. (19598107)
2010
11
Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. (20696760)
2010
12
Genetically confirmed Huntington's disease masquerading as motor neuron disease. (18186118)
2008
13
c-Jun N-terminal kinase mediates lactacystin-induced dopamine neuron degeneration. (18800014)
2008
14
Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder. (17270400)
2007
15
Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity. (17928447)
2007
16
Adult neuronal ceroid lipofuscinosis caused by deficiency in palmitoyl protein thioesterase 1. (17261688)
2007
17
Mutation of RET proto-oncogene in Hirschsprung's disease and intestinal neuronal dysplasia. (16534860)
2006
18
Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons. (16054660)
2005
19
Ubiquilin-1 regulates nicotine-induced up-regulation of neuronal nicotinic acetylcholine receptors. (16091357)
2005
20
Gene symbol: CLN3. Disease: juvenile neuronal ceroid lipofuscinosis (Batten disease). (15818814)
2005
21
PLA2 and secondary metabolites of arachidonic acid control filopodial behavior in neuronal growth cones. (14648557)
2004
22
Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder. (15569888)
2004
23
Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons. (15066270)
2004
24
Paraneoplastic limbic encephalitis (PLE) and chorea associated with CRMP-5 neuronal antibody. (14663059)
2003
25
Expression of estrogen receptor subtypes and neuronal nitric oxide synthase in neutrophils from women and men: regulation by estrogen. (12237165)
2002
26
Gas1 is induced during and participates in excitotoxic neuronal death. (11906213)
2002
27
Charting the effects of antioxidant therapy in the diseased brain: focus on "vitamin E deficiency and metabolic deficits in neuronal ceroid lipofuscinosis described by bioinformatics". (12464692)
2002
28
Herpes simplex virus mediated nerve growth factor expression in bladder and afferent neurons: potential treatment for diabetic bladder dysfunction. (11342969)
2001
29
An independent non-neuronal cholinergic system in lymphocytes. (11243565)
2001
30
Minimal ischaemic neuronal damage and HSP70 expression in MF1 strain mice following bilateral common carotid artery occlusion. (11578611)
2001
31
Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. (11567616)
2001
32
Symposia: maternal stress, motor neuron disease, antidepressants, and schizophrenia. (16049826)
2000
33
Neuronal intranuclear hyaline inclusion disease with polyglutamine-immunoreactive inclusions. (10805106)
2000
34
RNA diversity has profound effects on the translation of neuronal nitric oxide synthase. (10518591)
1999
35
Differential origins of neocortical projection and local circuit neurons: role of Dlx genes in neocortical interneuronogenesis. (10498283)
1999
36
Neuregulin in neuron/glial interactions in the central nervous system. GGF2 diminishes autoimmune demyelination, promotes oligodendrocyte progenitor expansion, and enhances remyelination. (10635037)
1999
37
Molecular genetics of the neuronal ceroid lipofuscinoses. (10446748)
1999
38
Differentiation of LA-N-5 neuroblastoma cells into cholinergic neurons: methods for differentiation, immunohistochemistry and reporter gene introduction. (9507116)
1998
39
Strands of embryonic mesencephalic tissue show greater dopamine neuron survival and better behavioral improvement than cell suspensions after transplantation in parkinsonian rats. (9739108)
1998
40
Premotor neurons for vertical eye movements in the rostral mesencephalon of monkey and human: histologic identification by parvalbumin immunostaining. (9514507)
1998
41
Movement of villi induces endocytosis of NK1 receptors in myenteric neurons from guinea-pig ileum. (9506910)
1998
42
Oxypurinol, a xanthine oxidase inhibitor and a superoxide scavenger, did not attenuate ischemic neuronal damage in gerbils. (9718087)
1998
43
TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis. (9218605)
1997
44
mu-Opioids activate tyrosine kinase focal adhesion kinase and regulate cortical cytoskeleton proteins cortactin and vinculin in chick embryonic neurons. (9364324)
1997
45
Neuron-specific enolase (NSE) serum level in non small cell lung cancer--can it be an indicator of tumour chemosensitivity? (9337535)
1997
46
A tau promoter region without neuronal specificity. (8632146)
1996
47
Regulation of acetylcholinesterase expression during neuronal differentiation. (8626792)
1996
48
Estradiol increases tyrosine hydroxylase activity of the A15 nucleus dopaminergic neurons during long days in the ewe. (7912958)
1994
49
Thymopoietin, a thymic polypeptide, potently interacts at muscle and neuronal nicotinic alpha-bungarotoxin receptors. (1463587)
1992
50
Fibroblast growth factor induces beta-amyloid precursor mRNA in glial but not neuronal cultured cells. (1690006)
1990

Genetic Variations for Neuronitis

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Expression for genes affiliated with Neuronitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuronitis

Search GEO for disease gene expression data for Neuronitis.

Pathways for genes affiliated with Neuronitis

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53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Neuronitis

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Neuronitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glutamate4412.1ENO2, SLC1A1, CLN3, CHRNA7, NPTX1, NPTX2
2galantamine44 49 1113.8CHRNA6, CHRNA7, CHRNA2, CHRNB2
3nicotine44 49 28 1114.7CHRNA6, CHRNA7, CHRNA2, CHRNB2
4potassium44 11 2413.6ENO2, SLC1A1, CHRNB2, NPTX1
5mecamylamine28 44 1113.5CHRNA6, CHRNA7, CHRNA2
6ly2087101 2811.2CHRNA2, CHRNA7
7[3h]epibatidine2811.2CHRNA7, CHRNA2
8varenicline44 1112.1CHRNA7, CHRNA6
9nmda44 2812.0NOS1AP, SLC1A1, CHRNA7
10hexamethonium44 2811.9CHRNA2, CHRNA6

GO Terms for genes affiliated with Neuronitis

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16Gene Ontology
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Cellular components related to Neuronitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588612.9APBA2, APBA1, CHRNB2, CHRNA2, CHRNA7, CHRNA6
2acetylcholine-gated channel complexGO:00589211.6CHRNA6, CHRNA7, CHRNA2, CHRNB2
3cell junctionGO:03005411.6CHRNA6, CHRNA7, CHRNA2, CHRNB2
4postsynaptic membraneGO:04521111.5CHRNB2, CHRNA2, CHRNA7, CHRNA6

Biological processes related to Neuronitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726813.4SLC1A1, APBA2, APBA1, NPTX2, NPTX1, CHRNB2
2ion transportGO:00681111.8SLC1A1, CHRNA7, CHRNA2, CHRNB2
3locomotory behaviorGO:00762611.4APBA2, APBA1, CHRNB2
4central nervous system developmentGO:00741711.4PNMA1, NPAS1, NPTX1
5regulation of dopamine secretionGO:01405911.1CHRNA6, CHRNB2
6cognitionGO:05089011.0CHRNB2, CHRNA7
7response to nicotineGO:03509411.0CHRNA7, CHRNB2
8associative learningGO:00830610.9CLN3, CHRNB2
9membrane depolarizationGO:05189910.7CHRNA6, CHRNB2

Molecular functions related to Neuronitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine receptor activityGO:01546411.6CHRNA6, CHRNA7, CHRNA2, CHRNB2
2acetylcholine-activated cation-selective channel activityGO:00488911.5CHRNB2, CHRNA2, CHRNA7, CHRNA6
3acetylcholine bindingGO:04216611.0CHRNA7, CHRNB2
4beta-amyloid bindingGO:00154011.0CHRNA7, APBA1, APBA2

Products for genes affiliated with Neuronitis

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Sources for Neuronitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet