Aliases & Classifications for Neuronitis

MalaCards integrated aliases for Neuronitis:

Name: Neuronitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8117
NCIt 46 C34847
UMLS 69 C0027881

Summaries for Neuronitis

Disease Ontology : 12 A central nervous system disease that is characterized by neuron inflammation.

MalaCards based summary : Neuronitis is related to myocarditis and ewing sarcoma. An important gene associated with Neuronitis is MB (Myoglobin), and among its related pathways/superpathways are TRAF Pathway and Apoptosis and Autophagy. The drugs Prednisolone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord.

Related Diseases for Neuronitis

Diseases related to Neuronitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1353)
# Related Disease Score Top Affiliating Genes
1 myocarditis 28.6 CD40LG MB
2 ewing sarcoma 28.3 CD40LG TNFRSF10A
3 celiac disease 1 28.3 CD40LG TNFRSF10A
4 ceroid lipofuscinosis, neuronal, 1 12.5
5 ceroid lipofuscinosis, neuronal, 10 12.4
6 ceroid lipofuscinosis, neuronal, 5 12.4
7 ceroid lipofuscinosis, neuronal, 2 12.4
8 ceroid lipofuscinosis, neuronal, 3 12.4
9 ceroid lipofuscinosis, neuronal, 6 12.4
10 neuronal ceroid lipofuscinosis 12.4
11 motor neuron disease 12.4
12 ceroid lipofuscinosis, neuronal, 8, northern epilepsy variant 12.4
13 ceroid lipofuscinosis, neuronal, 7 12.3
14 ceroid lipofuscinosis, neuronal, 4a, autosomal recessive 12.3
15 ceroid lipofuscinosis, neuronal, 4b, autosomal dominant 12.3
16 ceroid lipofuscinosis, neuronal, 8 12.3
17 ceroid lipofuscinosis, neuronal, 13 12.3
18 adult neuronal ceroid lipofuscinosis 12.3
19 neuronal intranuclear inclusion disease 12.2
20 ceroid lipofuscinosis, neuronal, 11 12.2
21 neuronal migration disorders 12.2
22 madras motor neuron disease 12.2
23 ceroid lipofuscinosis, neuronal, 9 12.2
24 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 12.1
25 neuronal intestinal dysplasia 12.1
26 intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked 12.1
27 vestibular neuronitis 12.1
28 neuronal ceroid-lipofuscinoses 12.1
29 amyotrophic lateral sclerosis 1 12.0
30 survival motor neuron spinal muscular atrophy 12.0
31 neuronal intestinal dysplasia, type b 11.9
32 nodular neuronal heterotopia 11.8
33 alzheimer disease neuronal thread protein 11.8
34 charcot-marie-tooth disease, guadalajara neuronal type 11.7
35 neuropathy, hereditary sensorimotor, with upper motor neuron, visual pathway and autonomic disturbance 11.7
36 motor neuron disease with dementia and ophthalmoplegia 11.7
37 focal or multifocal malformations in neuronal migration 11.7
38 neuronal interstitial dysplasia 11.7
39 lateral sclerosis 11.7
40 pick disease of brain 11.7
41 amyotrophic lateral sclerosis 4, juvenile 11.7
42 mitochondrial dna depletion syndrome 4a 11.7
43 frontotemporal dementia 11.6
44 neuronopathy, distal hereditary motor, type viib 11.6
45 spinal muscular atrophy, distal, autosomal recessive, 4 11.6
46 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 11.5
47 alzheimer disease 11.4
48 epilepsy, progressive myoclonic, 3, with or without intracellular inclusions 11.4
49 spastic paraplegia 39, autosomal recessive 11.4
50 mental retardation, autosomal dominant 13 11.4

Graphical network of the top 20 diseases related to Neuronitis:



Diseases related to Neuronitis

Symptoms & Phenotypes for Neuronitis

Drugs & Therapeutics for Neuronitis

Drugs for Neuronitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4 Prednisolone acetate Phase 4,Phase 3
5 glucocorticoids Phase 4,Phase 3,Phase 2
6 Methylprednisolone acetate Phase 4,Phase 3
7 Methylprednisolone Hemisuccinate Phase 4,Phase 3
8 Gastrointestinal Agents Phase 4,Phase 3
9 Neuroprotective Agents Phase 4,Phase 3
10 Hormone Antagonists Phase 4,Phase 3,Phase 2
11 Hormones Phase 4,Phase 3,Phase 2
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
13 Peripheral Nervous System Agents Phase 4,Phase 3
14 Antiemetics Phase 4,Phase 3
15 Prednisolone hemisuccinate Phase 4,Phase 3
16 Prednisolone phosphate Phase 4,Phase 3
17 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
18 Protective Agents Phase 4,Phase 3
19 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
20 Autonomic Agents Phase 4,Phase 3
21 Betamethasone Valerate Phase 4 2152-44-5
22 Respiratory System Agents Phase 4,Phase 3
23 Anti-Asthmatic Agents Phase 4,Phase 3
24 Betamethasone benzoate Phase 4
25 Betamethasone sodium phosphate Phase 4
26 Betamethasone-17,21-dipropionate Phase 4
27
Cilostazol Approved, Investigational Phase 3 73963-72-1 2754
28 Fibrinolytic Agents Phase 3
29 Vasodilator Agents Phase 3
30 Phosphodiesterase 3 Inhibitors Phase 3
31 Phosphodiesterase Inhibitors Phase 3
32 Platelet Aggregation Inhibitors Phase 3
33 Bronchodilator Agents Phase 3
34 Ginkgo Nutraceutical Phase 3
35
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
36
Dexamethasone Approved, Investigational, Vet_approved Early Phase 1 50-02-2 5743
37
Menthol Approved Early Phase 1 2216-51-5 16666
38 Dexamethasone acetate Early Phase 1 1177-87-3
39 BB 1101 Early Phase 1

Interventional clinical trials:

(show all 14)

# Name Status NCT ID Phase Drugs
1 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Recruiting NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
2 The Efficacy of Steroid Therapy in Vestibular Neuritis Unknown status NCT02098330 Phase 3 Ginkgo biloba & Methylprednisolone;Ginkgo biloba
3 Effect of Renexin Tablet in Patients With Recurrent Vestibulopathy Terminated NCT01895400 Phase 3 Renexin (cilostazol 100mg + gingko biloba extract 80 mg);Placebo
4 Prednisone Treatment for Vestibular Neuronitis Completed NCT00271791 Phase 2 Prednisone;Prednisone
5 Complementary/Alternative Medicine for Abnormality in the Vestibular (Balance) System Completed NCT00032383 Phase 1, Phase 2
6 Characterisation of Cortical Vestibular Evoked Potentials (C-VEPs) Unknown status NCT02463695
7 The Role of Corticosteroids and Vestibular Exercises in Recovery of Vestibular Neuritis Unknown status NCT01231009 Early Phase 1 Corticosteroids
8 Vestibular System in Migrainous Vertigo Patients Unknown status NCT00901953
9 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216
10 Home-based Computer Gaming in Vestibular Rehabilitation Completed NCT01943955
11 Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool Completed NCT02171312
12 MRIPositive Diagnosis of Vestibular Neuritis Using Fluid Attenuated Inversion Recuperation (FLAIR) Sequence on a 1.5 Tesla Recruiting NCT03452410
13 Assessment and Treatment of Patients With Long-term Dizziness in Primary Care Recruiting NCT02655575
14 Vestibulopathy With Vestibulo Ocular Reflex (VOR) Gain Deficit Not yet recruiting NCT03271775

Search NIH Clinical Center for Neuronitis

Genetic Tests for Neuronitis

Anatomical Context for Neuronitis

MalaCards organs/tissues related to Neuronitis:

38
Brain, Cortex, Spinal Cord, Lung, Dorsal Root Ganglion, Bone, Hypothalamus

Publications for Neuronitis

Articles related to Neuronitis:

(show top 50) (show all 17282)
# Title Authors Year
1
Differential roles of Na<sub>V</sub>1.2 and Na<sub>V</sub>1.6 in regulating neuronal excitability at febrile temperature and distinct contributions to febrile seizures. ( 29335582 )
2018
2
IL-18 Contributes to Bone Cancer Pain by Regulating Glia Cells and Neuron Interaction. ( 29079540 )
2018
3
Autoantibodies to the survival of motor neuron complex in a patient with necrotizing autoimmune myopathy. ( 29088473 )
2018
4
Motor neuron disease: A prospective natural history study of type 1 spinal muscular atrophy. ( 29348544 )
2018
5
Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis. ( 29378861 )
2018
6
Erythropoietin, a putative neurotransmitter during hypoxia, is produced in RVLM neurons and activates them in neonatal Wistar rats. ( 29443550 )
2018
7
Motor neuron disease: Positive trial results published for ground-breaking SMA therapies. ( 29146955 )
2018
8
Identification of two novel null variants in CLN8 by targeted next-generation sequencing: first report of a Chinese patient with neuronal ceroid lipofuscinosis due to CLN8 variants. ( 29422019 )
2018
9
Neuronal ceroid lipofuscinosis with severe biventricular impairment: a rare genetic disorder with associated myopathy? ( 29182766 )
2018
10
MicroRNA-16 targets mRNA involved in neurite extension and branching in hippocampal neurons during presymptomatic prion disease. ( 29277556 )
2018
11
Pragmatic approach to muscle MRI biomarkers in motor neuron disease. ( 29142141 )
2018
12
Downbeat nystagmus and lower motor neuron disease: 14A years follow-up. ( 29396677 )
2018
13
Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease. ( 29293261 )
2018
14
Ligustrazine suppresses neuron apoptosis via the Bax/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia. ( 29247598 )
2018
15
Preservation of neuronal function as measured by clinical and MRI endpoints in relapsing-remitting multiple sclerosis: how effective are current treatment strategies? ( 29411688 )
2018
16
NGF-dependent neurons and neurobiology of emotions and feelings: Lessons from congenital insensitivity to pain with anhidrosis. ( 29407522 )
2018
17
Neuronal loss and gliosis in the rat striatum subjected to 15 and 30 minutes of middle cerebral artery occlusion. ( 29354885 )
2018
18
A case of neuronal intranuclear inclusion disease associated with lupus nephritis-like nephropathy. ( 29430526 )
2018
19
Imaging muscle as a potential biomarker of denervation in motor neuron disease. ( 29089397 )
2018
20
Neuronal ceroid lipofuscinosis in Salukis is caused by a single base pair insertion in CLN8. ( 29446145 )
2018
21
Activation of Sigma-1 Receptor by Cutamesine Attenuates Neuronal Apoptosis by Inhibiting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in a Rat Model of Asphyxia Cardiac Arrest. ( 29424796 )
2018
22
Robust Neuronal Discrimination in Primary Auditory Cortex Despite Degradations of Spectro-temporal Acoustic Details: Comparison Between Guinea Pigs with Normal Hearing and Mild Age-Related Hearing Loss. ( 29302822 )
2018
23
Vinpocetine protects inner retinal neurons with functional NMDA glutamate receptors against retinal ischemia. ( 29106899 )
2018
24
Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder. ( 29402935 )
2018
25
Atypical lower motor neuron disease with enlargement of Nissl substance: Report of an autopsy case. ( 29350170 )
2018
26
Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer. ( 29357732 )
2018
27
Motor neuron disease in 2017: Progress towards therapy in motor neuron disease. ( 29348545 )
2018
28
The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile. ( 29366594 )
2018
29
Bardet-Biedl syndrome-8 (BBS8) protein is crucial for the development of outer segments in photoreceptor neurons. ( 29126234 )
2018
30
Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia. ( 29339464 )
2018
31
Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila. ( 29357349 )
2018
32
Effects of Alcohol Abuse on Proliferating Cells, Stem/Progenitor Cells, and Immature Neurons in the Adult Human Hippocampus. ( 29052615 )
2018
33
Dystonia-4 (DYT4)-associated TUBB4A mutants exhibit disorganized microtubule networks and inhibit neuronal process growth. ( 29127012 )
2018
34
Arginase-1 expressing microglia in close proximity to motor neurons were increased early in disease progression in canine degenerative myelopathy, a model of amyotrophic lateral sclerosis. ( 29408267 )
2018
35
Mercury and Motor Neuron Disease: Hooked on a Hypothesis. ( 29443385 )
2018
36
No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder. ( 29136601 )
2018
37
Treatment with low doses of aspirin during chronic phase of experimental Chagas' disease increases oesophageal nitrergic neuronal subpopulation in mice. ( 29349896 )
2018
38
Motor neuron disease mortality rates in New Zealand 1992-2013. ( 29382218 )
2018
39
Inducible transgenic expression of tripeptidyl peptidase 1 in a mouse model of late-infantile neuronal ceroid lipofuscinosis. ( 29408933 )
2018
40
DCC/NTN1 complex mutations in patients with congenital hypogonadotropic hypogonadism impair GnRH neuron development. ( 29202173 )
2018
41
Significant transcriptional changes in 15q duplication but not Angelman syndrome deletion stem cell-derived neurons. ( 29423132 )
2018
42
Neuronal Migration Disorders. ( 29298944 )
2018
43
Spinal PKC activation - Induced neuronal HMGB1 translocation contributes to hyperalgesia in a bone cancer pain model in rats. ( 29428215 )
2018
44
Loss of Angelman Syndrome Protein E6AP Disrupts a Novel Antagonistic Estrogen-Retinoic Acid Transcriptional Crosstalk in Neurons. ( 29388081 )
2018
45
Acamprosate rescues neuronal defects in the Drosophila model of Fragile X Syndrome. ( 29317220 )
2018
46
Canine neuronal ceroid lipofuscinoses: Promising models for preclinical testing of therapeutic interventions. ( 28860089 )
2017
47
Startle suppression after mild traumatic brain injury is associated with an increase in pro-inflammatory cytokines, reactive gliosis and neuronal loss in the caudal pontine reticular nucleus. ( 28089558 )
2017
48
Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection. ( 28786780 )
2017
49
Long-term follow-up of two siblings with adult-onset neuronal ceroid lipofuscinosis, Kufs type A. ( 28587997 )
2017
50
Survival of motor neurone protein is required for normal postnatal development of the spleen. ( 27726134 )
2017

Variations for Neuronitis

Expression for Neuronitis

Search GEO for disease gene expression data for Neuronitis.

Pathways for Neuronitis

Pathways related to Neuronitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.69 CD40LG TNFRSF10A
2 11.22 CD40LG TNFRSF10A
3
Show member pathways
10.54 CD40LG TNFRSF10A

GO Terms for Neuronitis

Biological processes related to Neuronitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 8.96 CD40LG TNFRSF10A
2 tumor necrosis factor-mediated signaling pathway GO:0033209 8.62 CD40LG TNFRSF10A

Sources for Neuronitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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