MCID: NRP001
MIFTS: 61

Neuropathy malady

Neuronal diseases category

Summaries for Neuropathy

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may affect sensation, movement,... more...

MalaCards: Neuropathy is related to diabetic neuropathy and peripheral neuropathy. An important gene associated with Neuropathy is GJB1 (gap junction protein, beta 1, 32kDa), and among its related pathways is Neural Crest Differentiation. The compounds serine and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include nerves or nerve cells, testes and heart, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A nervous system disease that is located in nerves or nerve cells.

Aliases & Classifications for Neuropathy

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuropathy 8 10 60


External Ids:

Disease Ontology8 DOID:870
NCIt39 C4731

Related Diseases for Neuropathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1055)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic neuropathy31.8PMP22, MPZ, NGF
2peripheral neuropathy31.7WNK1, SLC12A6, SPTLC1
3autonomic neuropathy31.6NGF
4hereditary sensory neuropathy31.3SPTLC1, NGF
5hereditary neuropathy with liability to pressure palsies31.2PMP22
6brachial plexus neuropathy30.9MPZ, PMP22
7charcot-marie-tooth disease30.9PMP22, MPZ
8tooth disease30.8PMP22, MPZ, GJB1
9polyneuropathy30.8PMP22, GAN, MPZ, PRX, GJB1, PNPLA6
10sensory peripheral neuropathy30.7GJB1, SLC12A6, SPTLC1, GDAP1, NGF, PRX
11motor peripheral neuropathy30.6MPZ, PMP22
12paraplegia30.5PNPLA6
13neuritis30.5PMP22, MPZ
14charcot-marie-tooth neuropathy type 130.5NEFL, MPZ, PMP22
15myopathy30.5MPZ, GARS, MFN2, PMP22, NEFL, MTMR2
16hereditary neuropathies30.4PMP22, MPZ, MTMR2, PRX, GJB1
17charcot-marie-tooth neuropathy type 230.4MFN2, GARS, MPZ, NEFL, GDAP1
18polyradiculoneuropathy30.3PMP22
19charcot-marie-tooth disease type 4e30.2PMP22, MPZ
20chronic inflammatory demyelinating polyradiculoneuropathy30.1PMP22, MPZ
21charcot-marie-tooth disease type 330.1PMP22, MPZ, GJB1
22neuropathy, recurrent, with pressure palsies30.1PMP22, CMT1A
23charcot-marie-tooth neuropathy type 429.9GDAP1, PRX, MTMR2
24charcot-marie-tooth neuropathy type 1a29.8MPZ, PMP22
25charcot-marie-tooth disease type 1e29.8PMP22, CMT1A
26charcot-marie-tooth disease type 1a29.8PMP22, CMT1A
27neuroaxonal dystrophy29.8GAN
28pelizaeus-merzbacher disease29.6MPZ
29diabetic autonomic neuropathy11.0
30ischemic neuropathy11.0
31ischemic optic neuropathy11.0
32axonal neuropathy10.9
33ulnar neuropathy10.9
34leber hereditary optic neuropathy10.8
35femoral neuropathy10.8
36diabetes mellitus10.7
37giant axonal neuropathy10.7
38sciatic neuropathy10.6
39neuronitis10.6
40peroneal neuropathy10.6
41retinitis10.6
42alcoholic neuropathy10.5
43median neuropathy10.5
44uremic neuropathy10.5
45charcot-marie-tooth hereditary neuropathy10.5
46hereditary sensory and autonomic neuropathy type ii10.5
47toxic optic neuropathy10.5
48type 2 diabetes mellitus10.4
49autonomic peripheral neuropathy10.4
50distal hereditary motor neuropathy10.4

Graphical network of the top 20 diseases related to Neuropathy:



Diseases related to neuropathy

Clinical Features for Neuropathy

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Drugs & Therapeutics for Neuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Neuropathy

Drug clinical trials:

Search ClinicalTrials for Neuropathy

Search NIH Clinical Center for Neuropathy

Search CenterWatch for Neuropathy

Genetic Tests for Neuropathy

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Anatomical Context for Neuropathy

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Neuropathy:

32
Testes, Heart, Skin, Brain, Eye, Bone, Liver, Spinal cord, Breast, Endothelial, Lung, T cells, Thyroid, Colon, Kidney, B cells, Bone marrow, Dorsal root ganglion, Prostate, Pituitary, Skeletal muscle, Whole blood, Pancreas, Tongue, Spleen, Salivary gland, Thalamus, Amygdala, Trigeminal ganglion, Pancreatic islet, Globus pallidus, Temporal lobe, Lymph node, Cortex, Monocytes, Smooth muscle, Small intestine, Adrenal gland

FMA organs/tissues related to Neuropathy:

14
Nerves or nerve cells

Animal Models for Neuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363112.9SPTLC1, PMP22, MFN2, GAN, GARS, MPZ
2MP:000538612.5PMP22, MFN2, GAN, GARS, MPZ, MTMR2
3MP:001076812.2MPZ, GARS, GAN, MFN2, MTMR2, NGF
4MP:000537811.9PMP22, MFN2, GAN, GARS, MTMR2, PRX
5MP:000536911.6PMP22, MFN2, GAN, GARS, TRPV4, NGF

Publications for Neuropathy

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Sources:
50PubMed
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Articles related to Neuropathy:

(show top 50)    (show all 6834)
idTitleAuthorsYear
1
Association of suprascapular neuropathy with rotator cuff tendon tears and fatty degeneration. (24054975)
2013
2
Livedoid vasculopathy associated with peripheral neuropathy: a report of two cases. (24346927)
2013
3
Painful Diabetic Peripheral Neuropathy: Results of a Survey Characterizing the Perspectives and Misperceptions of Patients and Healthcare Practitioners. (24263740)
2013
4
Concurrent outbreaks of cholera and peripheral neuropathy associated with high mortality among persons internally displaced by a volcanic eruption. (24023752)
2013
5
Treatment of non-arteritic anterior ischemic optic neuropathy with high-dose systemic corticosteroids. (22644095)
2013
6
Compound Charcot-Marie-Tooth disease: a kindred with severe hereditary neuropathy, pupil abnormalities and a novel MPZ mutation. (23197742)
2013
7
Leprosy neuropathy: clinical presentations. (24141500)
2013
8
Toxic optic neuropathy. (22446922)
2012
9
Is Leber hereditary optic neuropathy treatable? Encouraging results with idebenone in both prospective and retrospective trials and an illustrative case. (22269948)
2012
10
Glucagon-like peptide 1, insulin, sensory neurons, and diabetic neuropathy. (22588388)
2012
11
A rare recessive distal hereditary motor neuropathy with HSJ1 chaperone mutation. (22522442)
2012
12
Experimental study of the etiology and pathogenesis of sciatic neuropathy under conditions of therapy for ischium fractures. (22803181)
2012
13
Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel. (22200546)
2012
14
Chemotherapy-induced peripheral neuropathy: prevention and treatment. (21814197)
2011
15
Magnetic resonance findings in the pregeniculate visual pathways in Leber hereditary optic neuropathy. (21593634)
2011
16
Peripheral neuropathy: discovering the 'Bumps': a new method to measure symptoms of peripheral neuropathy. (21691331)
2011
17
Integrin beta-3 L33P: a new insight into the pathogenesis of chronic oxaliplatin-induced peripheral neuropathy? (20192979)
2010
18
Association of cardiac autonomic neuropathy with subclinical myocardial dysfunction in type 2 diabetes. (21163448)
2010
19
Anterior ischemic optic neuropathy after intravitreal injection of bevacizumab. (19491650)
2009
20
Pathogenesis of nonarteritic anterior ischemic optic neuropathy. (19667362)
2009
21
Leber hereditary optic neuropathy mutations in the ND6 subunit of mitochondrial complex I affect ubiquinone reduction kinetics in a bacterial model of the enzyme. (17894548)
2008
22
Cochlear implantation in 3 adults with auditory neuropathy/auditory dys-synchrony. (18949967)
2008
23
Acute pan-dysautonomia as well as central nervous system involvement and peripheral neuropathies in a patient with systemic lupus erythematosus. (18551352)
2008
24
Linezolid-associated small-fiber neuropathy. (18601662)
2008
25
Changes in excitability properties associated with axonal regeneration in human neuropathy and mouse Wallerian degeneration. (18342570)
2008
26
Radiation-induced brachial plexus neuropathy - aetiopathogenesis, risk factors, differential diagnostics, symptoms and treatment. (17357008)
2007
27
Intravenous use of buprenorphine tablets associated with rhabdomyolysis and compressive sciatic neuropathy. (16546629)
2006
28
Anti-myelin-associated glycoprotein neuropathy. (16969155)
2006
29
Association of small fiber neuropathy with cardiac sympathetic dysfunction in sarcoidosis. (15881279)
2005
30
129th ENMC International Workshop: Clinical Trials for Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy, 27th October 2004, Schiphol airport, The Netherlands. (15792873)
2005
31
Bed footboard peroneal and tibial neuropathy. A further unusual type of Saturday night palsy. (14871452)
2004
32
Posterior ischemic optic neuropathy: case report of a rare complication after general surgery. (15162297)
2004
33
Chronic ischemia induces regional axonal damage in experimental primate optic neuropathy. (15477464)
2004
34
Multiple actions of systemic artemin in experimental neuropathy. (14528299)
2003
35
In vivo gene therapy for pyridoxine-induced neuropathy by herpes simplex virus-mediated gene transfer of neurotrophin-3. (11782980)
2002
36
Analysis of candidate genes for intrinsic neuropathy in a family with chronic idiopathic intestinal pseudo-obstruction. (11260216)
2001
37
Acute motor-sensory axonal neuropathy associated with active systemic lupus erythematosus and anticardiolipin antibodies. (17039164)
2001
38
Accessory deep peroneal neuropathy: collision technique diagnosis. (9427233)
1998
39
Localization of the giant axonal neuropathy gene to chromosome 16q24. (9450783)
1998
40
Childhood Leber's hereditary optic neuropathy (ND1/3460) with visual recovery. (9831004)
1998
41
Delayed neuropathy and inhibition of soluble neuropathy target esterase following the administration of organophosphorus compounds to hens. (9823777)
1998
42
Autonomic neuropathy in hemodialysis patients treated with recombinant human erythropoietin. (8946232)
1996
43
WITHDRAWN: Aldose reductase inhibitors for the prevention and treatment of diabetic peripheral neuropathy. (17636697)
1996
44
Ethyl octylphosphonofluoridate and analogs: optimized inhibitors of neuropathy target esterase. (8605290)
1995
45
Molecular genetics of amyloid neuropathy in Europe. (2566762)
1989
46
Evaluation of the vagal-sympathetic interaction in diabetics with autonomic neuropathy through power spectrum density analysis of the heart rate. A critical revision of the natural history of diabetic autonomic neuropathy is possible. (2737507)
1989
47
The hypertrophic forms of hereditary motor and sensory neuropathy. A study of hypertrophic Charcot-Marie-Tooth disease (HMSN type I) and Dejerine-Sottas disease (HMSN type III) in childhood. (3467805)
1987
48
Stress fracture of the iliac bone with subfascial femoral neuropathy: unusual complications at a bone graft donor site: case report. (6860856)
1983
49
Pseudomyotonia and tetany in a familial neuropathy resembling Charcot-Marie-Tooth disease. (757061)
1978
50
Letter: Brachial plexus neuropathy associated with infectious mononucleosis. (1268786)
1976

Genetic Variations for Neuropathy

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Expression for genes affiliated with Neuropathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuropathy

Search GEO for disease gene expression data for Neuropathy.

Pathways for genes affiliated with Neuropathy

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37NCBI BioSystems Database
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Pathways related to Neuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9GJB1, MPZ, PMP22

Compounds for genes affiliated with Neuropathy

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Neuropathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1serine4411.9SPTLC1, PMP22, GARS, MPZ, NGF, WNK1
2tyrosine4411.5GARS, MPZ, MTMR2, TRPV4, NGF, WNK1
3glutamate4411.2GJB1, NGF, NEFL, MPZ, GARS
4ganglioside4411.1PMP22, MPZ, NGF
5mipafox4410.9PNPLA6, NGF
62,3-cyclic nucleotide4410.9MPZ, PNPLA6
7dihydroprogesterone4410.8PMP22, MPZ
8dihydrotestosterone44 28 11 2413.6PMP22, MPZ, NGF

GO Terms for genes affiliated with Neuropathy

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16Gene Ontology
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Cellular components related to Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurofilamentGO:00588310.8NEFL, GAN

Biological processes related to Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:00821911.3PNPLA6, GAN, GARS, OPTN, PRX, TRPV4
2negative regulation of neuron projection developmentGO:01097710.8TRPV4, PMP22
3myelin assemblyGO:03228810.5MTMR2, PMP22

Products for genes affiliated with Neuropathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet