MCID: NRP001
MIFTS: 59

Neuropathy malady

Categories: Neuronal diseases, Immune diseases, Rare diseases

Aliases & Classifications for Neuropathy

Aliases & Descriptions for Neuropathy:

Name: Neuropathy 12 14 69
Peripheral Neuropathy 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:870
ICD10 33 G62.9
NCIt 47 C4731
UMLS 69 C0442874

Summaries for Neuropathy

Disease Ontology : 12 A nervous system disease that is located in nerves or nerve cells.

MalaCards based summary : Neuropathy, also known as peripheral neuropathy, is related to neuropathy, congenital hypomyelinating and hereditary motor and sensory neuropathy via, and has symptoms including back pain, headache and neuralgia. An important gene associated with Neuropathy is MPZ (Myelin Protein Zero), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Norepinephrine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and skin, and related phenotypes are behavior/neurological and cellular

Related Diseases for Neuropathy

Diseases in the Neuropathy family:

Autoimmune Neuropathy Hereditary Type 1 Neuropathy
Hereditary Type 2 Neuropathy Hereditary Neuropathies

Diseases related to Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1263)
id Related Disease Score Top Affiliating Genes
1 neuropathy, congenital hypomyelinating 33.7 GDAP1 GJB1 MPZ PMP22
2 hereditary motor and sensory neuropathy via 33.5 MFN2 PMP22
3 dejerine-sottas disease 33.2 GDAP1 GJB1 MFN2 MPZ PMP22
4 neuropathy, inflammatory demyelinating 32.9 GDAP1 GJB1 MFN2 MPZ PMP22
5 charcot-marie-tooth disease, type 1e 32.9 GJB1 MPZ PMP22
6 hereditary type 2 neuropathy 32.7 MPZ PMP22
7 charcot-marie-tooth disease, type 2j 32.7 GDAP1 GJB1 MFN2 MPZ PMP22
8 charcot-marie-tooth disease, axonal, type 2k 32.5 GDAP1 TDP1
9 cerebral atrophy 29.6 SPTLC1 SPTLC2 WNK1
10 dilated cardiomyopathy 29.5 MPZ NGF PMP22
11 status epilepticus 29.4 MPZ MT-ND4 PMP22
12 neuropathy, hereditary sensory and autonomic, type ii 12.1
13 nonarteritic anterior ischemic optic neuropathy 12.1
14 neuropathy, recurrent, with pressure palsies 12.1
15 diabetic neuropathy 12.1
16 neuropathy, hereditary sensory, type ie 12.1
17 agenesis of the corpus callosum with peripheral neuropathy 12.1
18 hereditary neuropathies 12.0
19 neuropathy, hereditary sensory and autonomic, type v 12.0
20 giant axonal neuropathy 12.0
21 neuromyotonia and axonal neuropathy, autosomal recessive 12.0
22 autonomic neuropathy 12.0
23 multifocal motor neuropathy 12.0
24 auditory neuropathy 12.0
25 charcot-marie-tooth neuropathy, x-linked dominant, 1 12.0
26 hereditary sensory neuropathy 12.0
27 neuropathy, hereditary motor and sensory, russe type 12.0
28 peripheral neuropathy, myopathy, hoarseness, and hearing loss 12.0
29 neuropathy, hereditary sensory and autonomic, type vii 12.0
30 neuropathy, hereditary sensory and autonomic, type vi 12.0
31 hereditary motor and sensory neuropathy, type iic 12.0
32 ischemic optic neuropathy 12.0
33 congenital cataracts, facial dysmorphism, and neuropathy 12.0
34 spinocerebellar ataxia, autosomal recessive with axonal neuropathy 12.0
35 ulnar neuropathy 12.0
36 hereditary motor and sensory neuropathy, okinawa type 12.0
37 neuropathy, hereditary sensory and autonomic, type ia 12.0
38 sensory peripheral neuropathy 11.9
39 auditory neuropathy, autosomal dominant, 1 11.9
40 neuropathy, hereditary sensory, type ib 11.9
41 hereditary motor and sensory neuropathy v 11.9
42 hereditary neuropathy with liability to pressure palsy 11.9
43 neuropathy, hereditary sensory, with spastic paraplegia 11.9
44 giant axonal neuropathy 2, autosomal dominant 11.9
45 ataxia neuropathy spectrum 11.9
46 spastic paraplegia, optic atrophy, and neuropathy 11.9
47 neuropathy, ataxia, and retinitis pigmentosa 11.9
48 neuropathy, hereditary motor and sensory, type vib 11.9
49 cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome 11.9
50 arteritic anterior ischemic optic neuropathy 11.9

Graphical network of the top 20 diseases related to Neuropathy:



Diseases related to Neuropathy

Symptoms & Phenotypes for Neuropathy

UMLS symptoms related to Neuropathy:


back pain, headache, neuralgia, pain, sciatica, seizures, syncope, tremor, chronic pain, atypical facial pain, neurologic symptoms, vertigo/dizziness, sleeplessness, hemiparesis

MGI Mouse Phenotypes related to Neuropathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.22 SLC12A6 SPTLC1 TDP1 AIFM1 GAN GDAP1
2 cellular MP:0005384 10.21 AIFM1 DIAPH3 GAN GDAP1 GJB1 HINT1
3 growth/size/body region MP:0005378 10.13 SPTLC2 WNK1 AIFM1 DIAPH3 GAN GJB1
4 homeostasis/metabolism MP:0005376 10.1 AIFM1 DIAPH3 GDAP1 GJB1 HINT1 MFN2
5 mortality/aging MP:0010768 9.97 AIFM1 DIAPH3 GAN GJB1 MFN2 MPZ
6 muscle MP:0005369 9.56 AIFM1 GAN MFN2 NGF PMP22 POLG
7 nervous system MP:0003631 9.5 SLC12A6 SPTLC1 TDP1 WNK1 AIFM1 GAN

Drugs & Therapeutics for Neuropathy

Drugs for Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 850)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
2
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
3
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068
4
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2 60142-96-3 3446
5
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
6
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
7
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 1 50-78-2 2244
8
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 33069-62-4 36314
9
Fexofenadine Approved Phase 4 83799-24-0 3348
10
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
11
Ciprofloxacin Approved, Investigational Phase 4,Phase 2,Phase 1 85721-33-1 2764
12
Isosorbide Dinitrate Approved Phase 4,Phase 3 87-33-2 6883
13
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
14
Stavudine Approved, Investigational Phase 4,Phase 3 3056-17-5 18283
15
Timolol Approved Phase 4,Phase 3,Phase 1 26839-75-8 33624 5478
16
Ephedrine Approved Phase 4,Phase 1 299-42-3 9294
17
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-24-8 5755
18
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
19
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 6857599, 9887054 43805
20
Bupivacaine Approved, Investigational Phase 4,Early Phase 1 2180-92-9, 38396-39-3 2474
21
Dorzolamide Approved Phase 4 120279-96-1 3154 5284549
22
Ziconotide Approved Phase 4 107452-89-1 447451
23
Ofloxacin Approved Phase 4,Phase 2,Phase 3 82419-36-1 4583
24
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
25
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
26
Metronidazole Approved Phase 4,Phase 2 443-48-1 4173
27
Nabilone Approved, Investigational Phase 4,Phase 3 51022-71-0 5284592
28
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
29
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
30
Saxagliptin Approved Phase 4 361442-04-8 11243969
31
Linezolid Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 165800-03-3 441401
32
Clindamycin Approved, Vet_approved Phase 4,Phase 2 18323-44-9 29029
33
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
34
Pseudoephedrine Approved Phase 4,Phase 1 90-82-4 7028
35
Tazobactam Approved Phase 4,Phase 3,Phase 2 89786-04-9 123630
36
Piperacillin Approved Phase 4,Phase 3,Phase 2 66258-76-2 43672
37
Aztreonam Approved Phase 4,Phase 2 78110-38-0 5362041 5742832
38
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 148553-50-8 5486971
39
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2 13422-51-0 11953898 5460373 44475014
40
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 83-43-2 6741
41
Fluorouracil Approved Phase 4,Phase 2,Phase 3,Phase 1 51-21-8 3385
42
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 216974-75-3
43
Levofloxacin Approved, Investigational Phase 4,Phase 2,Phase 3 100986-85-4 149096
44
Travoprost Approved Phase 4,Phase 3 157283-68-6 5282226
45
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
46
Lamotrigine Approved, Investigational Phase 4,Phase 3 84057-84-1 3878
47
Levodopa Approved Phase 4 59-92-7 6047
48
Simvastatin Approved Phase 4,Phase 2 79902-63-9 54454
49
Rifampin Approved Phase 4,Phase 2 13292-46-1 5458213 5381226
50
Carboplatin Approved Phase 4,Phase 3,Phase 1,Phase 2 41575-94-4 10339178 498142 38904

Interventional clinical trials:

(show top 50) (show all 1967)
id Name Status NCT ID Phase
1 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy Unknown status NCT00123136 Phase 4
2 Single Shot Intrathecal Ziconotide for Painful Neuropathy or Myelopathy Unknown status NCT01992562 Phase 4
3 Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy Unknown status NCT01770964 Phase 4
4 Omega-3 Fatty Acids and Chemotherapy-induced Neuropathy and Inflammation in Breast Cancer Unknown status NCT01049295 Phase 4
5 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
6 Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY Unknown status NCT00235222 Phase 4
7 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4
8 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
9 Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences. Unknown status NCT02033057 Phase 4
10 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4
11 Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4
12 Efficacy and Safety of Garamycin® Sponge (Gentamicin-Collagen Sponge) in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection Unknown status NCT01951768 Phase 4
13 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
14 Safety and Efficacy of Mecobalamin Injection in Peripheral Neuropathies Patients (Study JGAZSY091109) Completed NCT01192113 Phase 4
15 The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy Completed NCT02056366 Phase 4
16 Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study Completed NCT00614341 Phase 4
17 Frequency Modulated Neural Stimulation (FREMS) in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
18 A Randomized Double-Blind Study Testing the Effects of Pregabalin on Diabetic Neuropathy Completed NCT00573261 Phase 4
19 Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN) Completed NCT00726713 Phase 4
20 A Study on the Efficacy and Safety of Gabapentin in the Treatment of Patients With Painful Diabetic Neuropathy Completed NCT00644748 Phase 4
21 A Study to Compare Safety and Efficacy of Tramadol Hydrochloride/Acetaminophen With Gabapentin in Participants With Diabetic Neuropathy Completed NCT00634543 Phase 4
22 Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Diabetic Peripheral Neuropathy Completed NCT00380913 Phase 4
23 Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4
24 Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy Completed NCT00159679 Phase 4
25 A Study To Evaluate Pregabalin In Patients With Painful Diabetic Peripheral Neuropathy (DPN) Completed NCT00156078 Phase 4
26 Anodyne Therapy in Diabetic Sensory Neuropathy Completed NCT00120341 Phase 4
27 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4
28 A Study of the Efficacy and Safety of Pregabalin for the Treatment of Diabetic Peripheral Neuropathy or Postherpetic Neuralgia Completed NCT00629681 Phase 4
29 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4
30 Safety of Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy Completed NCT00159731 Phase 4
31 Evaluation of Rocker sOles in Diabetis Completed NCT02891928 Phase 4
32 A Study of the Effectiveness And Safety Of Lidoderm® As Add-On Treatment in Patients With Postherpetic Neuralgia, Diabetic Neuropathy, or Low Back Pain Completed NCT00904020 Phase 4
33 Alpha Lipoic Acid for Treatment of Diabetic Neuropathy Completed NCT02439879 Phase 4
34 Autonomic Nervous System Dysfunction and Peripheral Neuropathy in a Cohort of Asymptomatic Juvenile Diabetic Patients (Type I): A Case-Controlled Study Completed NCT00466778 Phase 4
35 A Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy (CIPN) Completed NCT01675531 Phase 4
36 Lidoderm® (Lidocaine Patch 5%) in Diabetic and Idiopathic Neuropathy Completed NCT00903851 Phase 4
37 Clinical Study for Assessment of the Efficacy of Gabapentin (Carbatin and Neurontin) in Patients With Neuropathy Pain Completed NCT02074267 Phase 4
38 Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Chemotherapy-Induced Neuropathy Completed NCT00380965 Phase 4
39 Efficacy and Tolerability of Carbamazepine CR in Diabetic Neuropathy Pain Completed NCT01089855 Phase 4
40 Maintenance of Effect of Duloxetine in Patients With Diabetic Peripheral Neuropathic Pain (DPNP) Completed NCT00322621 Phase 4
41 Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management Completed NCT01364298 Phase 4
42 Training "Pain Connoisseurs" for Efficient Analgesic Proof-of-Concept Studies Completed NCT02842554 Phase 4
43 An Open Label, Dose Finding Trial of Viagra for the Treatment of Neuropathic Pain (in Diabetes Mellitus) Completed NCT00194909 Phase 4
44 Pregabalin Treatment Of Peripheral Neuropathic Pain Associated With Diabetic Peripheral NeP (DPN), Postherpetic Neuralgia (PHN), HIV-related NeP (HIV), and Chemotherapy Induced NeP Completed NCT00407511 Phase 4
45 Asian Study on Cilostazol Effectivity in Neuropathies of Diabetes Mellitus Type 2-A Pilot Study in the Philippines Completed NCT01076478 Phase 4
46 Lovaza® and Microvascular Function in Type 2 Diabetes Completed NCT00931879 Phase 4
47 Effect of Arginine on Microcirculation in Patients With Diabetes Completed NCT00902616 Phase 4
48 Tolerability of Switching to Duloxetine for the Management of Diabetic Nerve Pain Completed NCT00266643 Phase 4
49 An Open-Label Comparison of Duloxetine to Other Alternatives for the Management of Diabetic Peripheral Neuropathic Pain Completed NCT00385671 Phase 4
50 Intrathecal Bolus Doses of Ziconotide Completed NCT01373983 Phase 4

Search NIH Clinical Center for Neuropathy

Genetic Tests for Neuropathy

Anatomical Context for Neuropathy

MalaCards organs/tissues related to Neuropathy:

39
Testes, Heart, Skin, Brain, Eye, Bone, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Neuropathy:

18
Nerves Or Nerve Cells

Publications for Neuropathy

Articles related to Neuropathy:

(show top 50) (show all 8088)
id Title Authors Year
1
Ulnar Neuropathy in Cyclists. ( 27886836 )
2017
2
Clinical Characteristics and Treatment Response of Peripheral Neuropathy in the Presence of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Experience at a Single Tertiary Center. ( 28079316 )
2017
3
Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28302535 )
2017
4
Genetic Prion Disease Caused by PRNP Q160X Mutation Presenting with an Orbitofrontal Syndrome, Cyclic Diarrhea, and Peripheral Neuropathy. ( 27716661 )
2017
5
A critical appraisal of the mild axonal peripheral neuropathy of late neurologic Lyme disease. ( 27914746 )
2017
6
Relative Frequencies of Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy in an Arab Population. ( 28099197 )
2017
7
Long-Term Outcomes in the Management of Painful Diabetic Neuropathy. ( 28065184 )
2017
8
Serum folate, vitamin B12 levels and diabetic peripheral neuropathy in type 2 diabetes: A meta-analysis. ( 28081987 )
2017
9
Chronic encephalopathy with ataxia, myoclonus, and auditory neuropathy: A case of bismuth poisoning. ( 28084272 )
2017
10
Neutrophil to Lymphocyte Ratio in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28367045 )
2017
11
Diet-induced dysmotility and neuropathy in the gut precedes endotoxemia and metabolic syndrome: the chicken and the egg revisited. ( 28078679 )
2017
12
Anti-allodynic effect of Buja in a rat model of oxaliplatin-induced peripheral neuropathy via spinal astrocytes and pro-inflammatory cytokines suppression. ( 28088201 )
2017
13
Femoral Neuropathy Following Spontaneous Retroperitoneal Hemorrhage After Cardiac Surgery: A Case Report. ( 28079661 )
2017
14
Nonarteritic Anterior Ischemic Optic Neuropathy and Intraocular Surgery. ( 28108001 )
2017
15
A rare case of erythema elevatum diutinum presenting as diffuse neuropathy. ( 28050587 )
2017
16
Assessment of nonarteritic anterior ischemic optic neuropathy with intravoxel incoherent motion diffusion-weighted imaging using readout-segmented echo-planar imaging, parallel imaging, and 2D navigator-based reacquisition. ( 28513892 )
2017
17
Smoking and Eye Pathologies. A systemic review. Part II. Retina diseases, uveitis, optic neuropathies, thyroid-associated orbitopathy. ( 28078992 )
2017
18
Neurophthalmological conditions mimicking glaucomatous optic neuropathy: analysis of the most common causes of misdiagnosis. ( 28073365 )
2017
19
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886887 )
2017
20
Trigeminal neuralgia and neuropathy in large sporadic vestibular schwannomas. ( 28084915 )
2017
21
Peroneal neuropathy in giant cell arteritis. ( 28028163 )
2017
22
Clinical effectiveness of low-level laser treatment on peripheral somatosensory neuropathy. ( 28074305 )
2017
23
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective CohortA Study. ( 28063480 )
2017
24
Optical Coherence Tomography Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28301863 )
2017
25
Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations. ( 28144995 )
2017
26
Compound Heterozygote Mutation of C12orf65 Causes Distal Motor Neuropathy and Optic Atrophy. ( 28091420 )
2017
27
Takayasu arteritis presenting as isolated anterior ischemic optic neuropathy. ( 28389774 )
2017
28
Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28316838 )
2017
29
Monitoring the short-term effect of intravenous immunoglobulins in multifocal motor neuropathy using motor unit number index. ( 27988478 )
2017
30
Perioperative nonarteritic anterior ischemic optic neuropathy in Jehovah's Witnesses. ( 28457303 )
2017
31
POLG2 deficiency causes adult-onset syndromic sensory neuropathy, ataxia and parkinsonism. ( 28078310 )
2017
32
Chronic Sciatic Neuropathy in Rat Reduces Voluntary Wheel-Running Activity With Concurrent Chronic Mechanical Allodynia. ( 27782944 )
2017
33
Diabetic Neuropathy: A Position Statement by the American Diabetes Association. ( 27999003 )
2017
34
The rare ethambutol-induced optic neuropathy: A case-report and literature review. ( 28079833 )
2017
35
Proteinase 3-antineutrophil cytoplasmic antibody-positive ulcerative colitis presenting with abducens neuropathy. ( 28069788 )
2017
36
Review of Critical Illness Myopathy and Neuropathy. ( 28042370 )
2017
37
A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV). ( 27676246 )
2017
38
Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma. ( 28068938 )
2017
39
Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28438311 )
2017
40
Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. ( 28077491 )
2017
41
Pathology of Ischemic Optic Neuropathy. ( 28029908 )
2017
42
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort Study. ( 28093100 )
2017
43
Optic atrophy, cataracts, lipodystrophy/lipoatrophy, and peripheral neuropathy caused by a de novo OPA3 mutation. ( 28050599 )
2017
44
Genetic and Clinical Analyses of DOA and LHON in 304 Chinese Patients with Suspected Childhood-Onset Hereditary Optic Neuropathy. ( 28081242 )
2017
45
Editorial: Limited Utility of the Handgrip Test for the Diagnosis of Diabetic Cardiovascular Autonomic Neuropathy: "There's Time Enough, But None to Spare". ( 27781938 )
2017
46
Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886893 )
2017
47
Brachial Plexus Blockade Causes Subclinical Neuropathy: A Prospective Observational Study. ( 28082843 )
2017
48
Cardiovascular Autonomic Neuropathy and Cardiovascular Outcomes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study. ( 27803120 )
2017
49
Prospective Case-crossover Study Investigating the Possible Association Between Nonarteritic Anterior Ischemic Optic Neuropathy and Phosphodiesterase Type 5 Inhibitor Exposure. ( 28336289 )
2017
50
Quantitative muscle ultrasound as a biomarker in Charcot-Marie-Tooth neuropathy. ( 27940147 )
2017

Variations for Neuropathy

ClinVar genetic disease variations for Neuropathy:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 NEFL NM_006158.4(NEFL): c.64C> T (p.Pro22Ser) single nucleotide variant Pathogenic/Likely pathogenic rs28928910 GRCh37 Chromosome 8, 24813966: 24813966
2 IARS2 NM_018060.3(IARS2): c.2726C> T (p.Pro909Leu) single nucleotide variant Pathogenic rs587783070 GRCh38 Chromosome 1, 220143109: 220143109

Copy number variations for Neuropathy from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 107544 17 15900000 22100000 Microdeletion Neuropathy
2 107574 17 16000000 22200000 Copy number Neuropathy
3 216423 6 92100000 98700000 Microdeletion EPHA7 Neuropathy

Expression for Neuropathy

Search GEO for disease gene expression data for Neuropathy.

Pathways for Neuropathy

Pathways related to Neuropathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.81 GJB1 MPZ PMP22

GO Terms for Neuropathy

Cellular components related to Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine C-palmitoyltransferase complex GO:0017059 8.62 SPTLC1 SPTLC2

Biological processes related to Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ceramide biosynthetic process GO:0046513 9.37 SPTLC1 SPTLC2
2 mitochondrial fusion GO:0008053 9.32 GDAP1 MFN2
3 sphingosine biosynthetic process GO:0046512 9.26 SPTLC1 SPTLC2
4 sphingomyelin biosynthetic process GO:0006686 9.16 SPTLC1 SPTLC2
5 positive regulation of lipophagy GO:1904504 8.96 SPTLC1 SPTLC2
6 sphinganine biosynthetic process GO:0046511 8.62 SPTLC1 SPTLC2

Molecular functions related to Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine C-palmitoyltransferase activity GO:0004758 8.62 SPTLC1 SPTLC2

Sources for Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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