MCID: NRP001
MIFTS: 52

Neuropathy malady

Neuronal diseases, Rare diseases categories

Aliases & Classifications for Neuropathy

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Neuropathy, Aliases & Descriptions:

Name: Neuropathy 9 11 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:870
NCIt38 C4731

Summaries for Neuropathy

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Disease Ontology:9 A nervous system disease that is located in nerves or nerve cells.

MalaCards based summary: Neuropathy is related to autonomic neuropathy and peripheral neuropathy. An important gene associated with Neuropathy is GJB1 (gap junction protein, beta 1, 32kDa), and among its related pathways are ceramide de novo biosynthesis and Neural Crest Differentiation. The compounds mipafox and 2,3-cyclic nucleotide have been mentioned in the context of this disorder. Affiliated tissues include nerves or nerve cells, testes and heart, and related mouse phenotypes are integument and muscle.

Related Diseases for Neuropathy

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Diseases in the Neuropathy family:

Hereditary Type 1 Neuropathy Hereditary Type 2 Neuropathy
Hereditary Neuropathies

Diseases related to Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1208)
idRelated DiseaseScoreTop Affiliating Genes
1autonomic neuropathy32.4NGF
2peripheral neuropathy32.2SLC12A6, WNK1, SPTLC1, SPTLC2
3diabetic neuropathy32.1MPZ, NGF, PMP22
4hereditary neuropathies31.7GJB1, MTMR2, MPZ, PMP22
5hereditary sensory neuropathy31.5SPTLC2, SPTLC1, NGF
6brachial plexus neuropathy31.5MPZ, PMP22
7tooth disease31.5GJB1, MPZ, PMP22
8neuropathy, recurrent, with pressure palsies31.3CMT1A, PMP22
9dejerine-sottas disease31.2PMP22, MPZ, GJB1
10polyneuropathy31.2PNPLA6, PMP22, MPZ, GJB1, GAN
11charcot-marie-tooth disease, type 1a31.1CMT1A, PMP22
12motor peripheral neuropathy31.0MPZ, PMP22
13charcot-marie-tooth neuropathy type 131.0MPZ, PMP22
14neuropathy, congenital hypomyelinating31.0MPZ, PMP22
15neuritis30.9MPZ, PMP22
16polyradiculoneuropathy30.9PMP22
17neuropathy, hereditary sensory, type ie30.7SPTLC1, SPTLC2
18chronic inflammatory demyelinating polyradiculoneuropathy30.7PMP22, MPZ
19charcot-marie-tooth neuropathy type 430.7MTMR2, GDAP1
20roussy-levy syndrome30.6PMP22, MPZ
21neuropathy, inflammatory demyelinating30.6PMP22, CMT1A
22sensorineural hearing loss30.6GJB1, PMP22
23guillain-barre syndrome30.6MPZ, PMP22
24charcot-marie-tooth disease30.5PMP22, MFN2, SPTLC1, GDAP1, MPZ, MTMR2
25charcot-marie-tooth disease, type 2e30.5GDAP1, MFN2, MPZ, GARS
26charcot-marie-tooth disease, type 1e30.4CMT1A, PMP22
27sensory peripheral neuropathy30.2SLC12A6, GJB1, MTMR2, MPZ, NGF, PMP22
28pelizaeus-merzbacher disease30.1MPZ
29myopathy30.1GDAP1, PNPLA6, MFN2, PMP22, NGF, MPZ
30demyelinating disease29.7MPZ, NGF
31ischemic optic neuropathy11.1
32axonal neuropathy10.9
33ulnar neuropathy10.9
34multifocal motor neuropathy10.9
35diabetic autonomic neuropathy10.9
36auditory neuropathy10.9
37leber hereditary optic neuropathy10.9
38hereditary neuropathy with liability to pressure palsy10.8
39nonarteritic anterior ischemic optic neuropathy10.8
40femoral neuropathy10.8
41giant axonal neuropathy10.8
42neuronitis10.6
43amyloid neuropathy10.6
44sciatic neuropathy10.6
45peroneal neuropathy10.6
46retinitis10.6
47ataxia10.6
48acute motor axonal neuropathy10.6
49median neuropathy10.6
50arteritic anterior ischemic optic neuropathy10.5

Graphical network of the top 20 diseases related to Neuropathy:



Diseases related to neuropathy

Symptoms for Neuropathy

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Drugs & Therapeutics for Neuropathy

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Drug clinical trials:

Search ClinicalTrials for Neuropathy

Search NIH Clinical Center for Neuropathy

Genetic Tests for Neuropathy

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Anatomical Context for Neuropathy

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MalaCards organs/tissues related to Neuropathy:

31
Testes, Heart, Skin, Eye, Brain, Bone, Liver, Breast, Spinal cord, Endothelial, Lung, Thyroid, T cells, Colon, B cells, Kidney, Bone marrow, Dorsal root ganglion, Whole blood, Skeletal muscle, Prostate, Pituitary, Spleen, Pancreas, Tongue, Neutrophil, Lymph node, Cortex, Smooth muscle, Small intestine, Salivary gland, Monocytes, Temporal lobe, Globus pallidus, Thalamus, Amygdala, Trigeminal ganglion, Pancreatic islet, Adrenal gland

FMA organs/tissues related to Neuropathy:

14
Nerves or nerve cells

Animal Models for Neuropathy or affiliated genes

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MGI Mouse Phenotypes related to Neuropathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.9PNPLA6, NGF, SPTLC2, KIF1A, SLC12A6, TRPV4
2MP:00053698.5WNK1, TRPV4, SLC12A6, GAN, GARS, NGF
3MP:00053768.1TRPV4, MFN2, PNPLA6, SPTLC1, MPZ, NGF
4MP:00053787.9MFN2, PMP22, NGF, WNK1, MTMR2, GJB1
5MP:00107687.5MFN2, GAN, SPTLC2, SPTLC1, PNPLA6, PMP22
6MP:00053867.5GJB1, GARS, GAN, SLC12A6, TRPV4, NGF
7MP:00036317.4GARS, SPTLC1, TRPV4, SLC12A6, GAN, GJB1

Publications for Neuropathy

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Articles related to Neuropathy:

(show top 50)    (show all 7218)
idTitleAuthorsYear
1
Giant Axonal Neuropathy. (25213662)
2014
2
How the impact of median neuropathy on sensorimotor control capability of hands for diabetes: an achievable assessment from functional perspectives. (24722361)
2014
3
Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy. (25192047)
2014
4
Goshajinkigan oxaliplatin neurotoxicity evaluation (GONE): a phase 2, multicenter, randomized, doublea89blind, placeboa89controlled trial of goshajinkigan to prevent oxaliplatina89induced neuropathy. (24121454)
2013
5
Mutational analysis of the 5' non-coding region of GJB1 in a Taiwanese cohort with Charcot-Marie-Tooth neuropathy. (23827825)
2013
6
The effect of diabetic neuropathy on foot bones: a systematic review and meta-analysis. (24151985)
2013
7
Long-term evaluation of radiation-induced optic neuropathy after single-fraction stereotactic radiosurgery. (24074926)
2013
8
The correlation between pain-related behaviour and spinal microgliosis in four distinct models of peripheral neuropathy. (22467279)
2012
9
Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. (23152654)
2012
10
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CBa88 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy. (22998838)
2012
11
Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation. (22861166)
2012
12
Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. (22496202)
2012
13
Neuromuscular ultrasound in the diagnosis of focal neuropathies superimposed on polyneuropathy: a case report. (21835689)
2012
14
Common fibular (peroneal) neuropathy as the result of a ganglion cyst. (23202278)
2012
15
Acute transverse myelitis and acute motor axonal neuropathy developed after vaccinations against seasonal and 2009 A/H1N1 influenza. (21372468)
2011
16
Motor nerve conduction study in cauda equina with high-voltage electrical stimulation in multifocal motor neuropathy and amyotrophic lateral sclerosis. (21254095)
2011
17
Peripheral neuropathies: Molecular diagnosis of Charcot-Marie-Tooth disease. (21587243)
2011
18
Four novel cases of periaxin-related neuropathy and review of the literature. (21079185)
2010
19
Synchronous auditory nerve activity in the carboplatin-chinchilla model of auditory neuropathy. (20649190)
2010
20
Auditory neuropathy associated with postnatally acquired cytomegalovirus infection in a very preterm infant. (22789691)
2010
21
Protection from clinical peripheral sensory neuropathy in AlstrAPm syndrome in contrast to early-onset type 2 diabetes. (19092165)
2009
22
Hereditary peripheral neuropathies]. (19327944)
2009
23
New liquid intravenous immunoglobulin (10 % IVIg) for treatment of multifocal motor neuropathy: a prospective study of efficacy, safety and tolerability. (18758888)
2008
24
The Neuropad test: a visual indicator test for human diabetic neuropathy. (18368386)
2008
25
An approach to the assessment of diabetic neuropathy based on dynamic pupillometry. (18002017)
2007
26
Radial and ulnar neuropathy due to pigmented villonodular synovitis of the elbow. (17126239)
2006
27
Erectile dysfunction as a sentinel symptom of cardiovascular autonomic neuropathy in heavy drinkers. (15574133)
2004
28
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
29
Posterior ischemic optic neuropathy related to profound shock after penetrating thoracoabdominal trauma. (12356108)
2002
30
Electrodiagnosis of ulnar neuropathy at the wrist: conduction block versus traditional tests. (12177377)
2002
31
Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome]. (10614173)
1999
32
Features of uremic neuropathy in long-term dialysis. (10097427)
1998
33
Hereditary thermosensitive neuropathy. (9674846)
1998
34
Cholecystoparesis with diabetic autonomic neuropathy. (9313105)
1997
35
Long term effect of intravenous immunoglobulins and oral cyclophosphamide in multifocal motor neuropathy. (9416813)
1997
36
Slowing of central conduction in X-linked Charcot-Marie-Tooth neuropathy shown by brain stem auditory evoked responses. (8676158)
1996
37
Operative treatment of medical epicondylitis. Influence of concomitant ulnar neuropathy at the elbow. (7608229)
1995
38
Three subgroups of patients from the United Kingdom with Leber hereditary optic neuropathy. (7821467)
1994
39
Late onset dysthyroid optic neuropathy. (7920007)
1994
40
Sparing of the flexor carpi ulnaris in ulnar neuropathy at the elbow. (1656251)
1991
41
Risk factors in nonarteritic anterior ischemic optic neuropathy. (2077825)
1990
42
Acute femoral neuropathy and iliopsoas infarction in intravenous drug abusers. (2166251)
1990
43
QT interval in diabetic autonomic neuropathy. (2147640)
1990
44
Membranous glomerulonephritis associated with chronic progressive demyelinating neuropathy. (3027615)
1987
45
Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy. (3742831)
1986
46
Axonal dystrophy in experimental diabetic autonomic neuropathy. (7160544)
1982
47
A new test to study diabetic autonomic neuropathy. (7227703)
1981
48
Hormonal, metabolic, and cardiovascular responses to hypoglycemia in diabetic autonomic neuropathy. (7018967)
1981
49
Nerve xenografts to apportion the role of axon and Schwann cell in myelinated fiber absence in hereditary sensory neuropathy, type II. (289909)
1979
50
9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy. (1094320)
1975

Variations for Neuropathy

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Expression for genes affiliated with Neuropathy

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Search GEO for disease gene expression data for Neuropathy.

Pathways for genes affiliated with Neuropathy

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Pathways related to Neuropathy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0SPTLC1, SPTLC2
29.9GJB1, MPZ, PMP22

Compounds for genes affiliated with Neuropathy

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Sources:
43Novoseek, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 12DrugBank
See all sources

Compounds related to Neuropathy according to GeneCards Suite gene sharing:

(show all 12)
idCompoundScoreTop Affiliating Genes
1mipafox4310.2NGF, PNPLA6
22,3-cyclic nucleotide4310.2PNPLA6, MPZ
3dihydroprogesterone4310.2PMP22, MPZ
4l-serine59 28 24 1213.1SPTLC2, SPTLC1
53-Dehydrosphinganine2410.0SPTLC1, SPTLC2
6ganglioside4310.0PMP22, NGF, MPZ
7dihydrotestosterone43 28 24 1212.9MPZ, NGF, PMP22
8ceramide439.8NGF, SPTLC1, SPTLC2
9gaba439.6GARS, GJB1, PMP22
10cysteine439.3PMP22, NGF, MPZ, GJB1, GARS
11tyrosine439.0NGF, MPZ, WNK1, MTMR2, GJB1, GARS
12serine438.8GARS, SPTLC2, SPTLC1, PNPLA6, PMP22, NGF

GO Terms for genes affiliated with Neuropathy

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Cellular components related to Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine C-palmitoyltransferase complexGO:001705910.0SPTLC1, SPTLC2

Biological processes related to Neuropathy according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1sphinganine biosynthetic processGO:004651110.2SPTLC1, SPTLC2
2sphingomyelin biosynthetic processGO:000668610.2SPTLC1, SPTLC2
3sphingosine biosynthetic processGO:004651210.2SPTLC2, SPTLC1
4ceramide biosynthetic processGO:004651310.1SPTLC1, SPTLC2
5myelin assemblyGO:003228810.1MTMR2, PMP22
6neuron developmentGO:004866610.0MTMR2, WNK1
7negative regulation of neuron projection developmentGO:00109779.9PMP22, TRPV4
8peripheral nervous system developmentGO:00074229.9NGF, PMP22
9sphingolipid biosynthetic processGO:00301489.7SPTLC1, SPTLC2
10cell deathGO:00082198.9TRPV4, PNPLA6, MFN2, KIF1A, GARS, GAN

Molecular functions related to Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine C-palmitoyltransferase activityGO:000475810.0SPTLC1, SPTLC2

Products for genes affiliated with Neuropathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet