MCID: NRP001
MIFTS: 62

Neuropathy malady

Neuronal diseases category
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Summaries for Neuropathy

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Wikipedia:65 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may impair sensation, movement,... more...

MalaCards based summary: Neuropathy is related to autonomic neuropathy and peripheral neuropathy. An important gene associated with Neuropathy is GJB1 (gap junction protein, beta 1, 32kDa), and among its related pathways are ceramide de novo biosynthesis and Neural Crest Differentiation. The compounds mipafox and 2,3-cyclic nucleotide have been mentioned in the context of this disorder. Affiliated tissues include nerves or nerve cells, testes and heart, and related mouse phenotypes are integument and muscle.

Disease Ontology:8 A nervous system disease that is located in nerves or nerve cells.

Aliases & Classifications for Neuropathy

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Neuropathy, Aliases & Descriptions:

Name: Neuropathy 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:870
NCIt39 C4731

Related Diseases for Neuropathy

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Diseases related to Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1197)
idRelated DiseaseScoreTop Affiliating Genes
1autonomic neuropathy32.4NGF
2peripheral neuropathy32.2SLC12A6, WNK1, SPTLC1, SPTLC2
3diabetic neuropathy32.1MPZ, NGF, PMP22
4hereditary neuropathy with liability to pressure palsies32.1PMP22
5hereditary neuropathies31.7GJB1, MTMR2, MPZ, PMP22
6charcot-marie-tooth disease31.6MPZ, PMP22
7hereditary sensory neuropathy31.5SPTLC2, SPTLC1, NGF
8brachial plexus neuropathy31.5MPZ, PMP22
9dnmt1-related dementia, deafness, and sensory neuropathy31.5SPTLC1, SPTLC2
10tooth disease31.5GJB1, MPZ, PMP22
11polyneuropathy31.2PNPLA6, PMP22, MPZ, GJB1, GAN
12charcot-marie-tooth disease type 1a31.1CMT1A, PMP22
13chronic inflammatory demyelinating polyneuropathy31.0PMP22, MPZ
14inherited peripheral neuropathy31.0PMP22, MPZ, GJB1
15charcot-marie-tooth neuropathy type 131.0MPZ, PMP22
16charcot-marie-tooth neuropathy type 1a31.0MPZ, PMP22
17polyradiculoneuropathy31.0PMP22
18neuritis31.0MPZ, PMP22
19charcot-marie-tooth disease type 430.9MPZ, PMP22
20neuropathy, recurrent, with pressure palsies30.8CMT1A, PMP22
21charcot-marie-tooth disease type 330.8PMP22, MPZ, GJB1
22guillain-barre syndrome30.6MPZ, PMP22
23charcot-marie-tooth disease type 130.6CMT1A, PMP22
24charcot-marie-tooth neuropathy type 230.6GDAP1, MFN2, MPZ, GARS
25charcot-marie-tooth neuropathy type 430.6MTMR2, GDAP1
26sensorineural hearing loss30.5GJB1, PMP22
27neuropathy, inflammatory demyelinating30.5PMP22, CMT1A
28pelizaeus-merzbacher disease30.4MPZ
29sensory peripheral neuropathy30.2SLC12A6, GJB1, MTMR2, MPZ, NGF, PMP22
30myopathy30.1GDAP1, PNPLA6, MFN2, PMP22, NGF, MPZ
31demyelinating disease29.7MPZ, NGF
32ischemic optic neuropathy11.0
33anterior ischemic optic neuropathy11.0
34axonal neuropathy10.9
35ulnar neuropathy10.9
36diabetic autonomic neuropathy10.9
37multifocal motor neuropathy10.9
38auditory neuropathy10.9
39leber hereditary optic neuropathy10.9
40hereditary neuropathy with liability to pressure palsy10.8
41femoral neuropathy10.8
42giant axonal neuropathy10.8
43diabetes mellitus10.7
44small fiber neuropathy10.7
45neuronitis10.6
46amyloid neuropathy10.6
47sciatic neuropathy10.6
48peroneal neuropathy10.6
49retinitis10.6
50ataxia10.6

Graphical network of the top 20 diseases related to Neuropathy:



Diseases related to neuropathy

Symptoms for Neuropathy

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Drugs & Therapeutics for Neuropathy

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Drug clinical trials:

Search ClinicalTrials for Neuropathy

Search NIH Clinical Center for Neuropathy

Genetic Tests for Neuropathy

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Anatomical Context for Neuropathy

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MalaCards organs/tissues related to Neuropathy:

32
Testes, Heart, Skin, Eye, Brain, Bone, Liver, Spinal cord, Breast, Endothelial, Lung, T cells, Colon, Thyroid, Kidney, B cells, Bone marrow, Whole blood, Prostate, Dorsal root ganglion, Pituitary, Skeletal muscle, Spleen, Pancreas, Tongue, Neutrophil, Lymph node, Cortex, Smooth muscle, Small intestine, Salivary gland, Monocytes, Temporal lobe, Globus pallidus, Thalamus, Amygdala, Trigeminal ganglion, Pancreatic islet, Adrenal gland

FMA organs/tissues related to Neuropathy:

14
Nerves or nerve cells

Animal Models for Neuropathy or affiliated genes

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MGI Mouse Phenotypes related to Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.9PNPLA6, NGF, KIF1A, SLC12A6, TRPV4, SPTLC2
2MP:00053698.5MFN2, PMP22, NGF, WNK1, GARS, GAN
3MP:00053768.1SPTLC2, SPTLC1, PNPLA6, MFN2, NGF, MPZ
4MP:00053787.9PNPLA6, MFN2, PMP22, NGF, WNK1, MTMR2
5MP:00107687.5PMP22, MFN2, PNPLA6, SPTLC1, SPTLC2, NGF
6MP:00053867.5NGF, PMP22, MFN2, PNPLA6, SPTLC1, MPZ
7MP:00036317.4TRPV4, SPTLC1, PNPLA6, MFN2, PMP22, NGF

Publications for Neuropathy

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Articles related to Neuropathy:

(show top 50)    (show all 7041)
idTitleAuthorsYear
1
Giant Axonal Neuropathy. (25213662)
2014
2
How the impact of median neuropathy on sensorimotor control capability of hands for diabetes: an achievable assessment from functional perspectives. (24722361)
2014
3
Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy. (25192047)
2014
4
Goshajinkigan oxaliplatin neurotoxicity evaluation (GONE): a phase 2, multicenter, randomized, doublea89blind, placeboa89controlled trial of goshajinkigan to prevent oxaliplatina89induced neuropathy. (24121454)
2013
5
Mutational analysis of the 5' non-coding region of GJB1 in a Taiwanese cohort with Charcot-Marie-Tooth neuropathy. (23827825)
2013
6
The effect of diabetic neuropathy on foot bones: a systematic review and meta-analysis. (24151985)
2013
7
Long-term evaluation of radiation-induced optic neuropathy after single-fraction stereotactic radiosurgery. (24074926)
2013
8
The correlation between pain-related behaviour and spinal microgliosis in four distinct models of peripheral neuropathy. (22467279)
2012
9
Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. (23152654)
2012
10
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CBa88 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy. (22998838)
2012
11
Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation. (22861166)
2012
12
Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. (22496202)
2012
13
Neuromuscular ultrasound in the diagnosis of focal neuropathies superimposed on polyneuropathy: a case report. (21835689)
2012
14
Common fibular (peroneal) neuropathy as the result of a ganglion cyst. (23202278)
2012
15
Acute transverse myelitis and acute motor axonal neuropathy developed after vaccinations against seasonal and 2009 A/H1N1 influenza. (21372468)
2011
16
Motor nerve conduction study in cauda equina with high-voltage electrical stimulation in multifocal motor neuropathy and amyotrophic lateral sclerosis. (21254095)
2011
17
Peripheral neuropathies: Molecular diagnosis of Charcot-Marie-Tooth disease. (21587243)
2011
18
Four novel cases of periaxin-related neuropathy and review of the literature. (21079185)
2010
19
Synchronous auditory nerve activity in the carboplatin-chinchilla model of auditory neuropathy. (20649190)
2010
20
Auditory neuropathy associated with postnatally acquired cytomegalovirus infection in a very preterm infant. (22789691)
2010
21
Protection from clinical peripheral sensory neuropathy in AlstrAPm syndrome in contrast to early-onset type 2 diabetes. (19092165)
2009
22
Hereditary peripheral neuropathies]. (19327944)
2009
23
New liquid intravenous immunoglobulin (10 % IVIg) for treatment of multifocal motor neuropathy: a prospective study of efficacy, safety and tolerability. (18758888)
2008
24
The Neuropad test: a visual indicator test for human diabetic neuropathy. (18368386)
2008
25
An approach to the assessment of diabetic neuropathy based on dynamic pupillometry. (18002017)
2007
26
Radial and ulnar neuropathy due to pigmented villonodular synovitis of the elbow. (17126239)
2006
27
Erectile dysfunction as a sentinel symptom of cardiovascular autonomic neuropathy in heavy drinkers. (15574133)
2004
28
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
29
Posterior ischemic optic neuropathy related to profound shock after penetrating thoracoabdominal trauma. (12356108)
2002
30
Electrodiagnosis of ulnar neuropathy at the wrist: conduction block versus traditional tests. (12177377)
2002
31
Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome]. (10614173)
1999
32
Features of uremic neuropathy in long-term dialysis. (10097427)
1998
33
Hereditary thermosensitive neuropathy. (9674846)
1998
34
Cholecystoparesis with diabetic autonomic neuropathy. (9313105)
1997
35
Long term effect of intravenous immunoglobulins and oral cyclophosphamide in multifocal motor neuropathy. (9416813)
1997
36
Slowing of central conduction in X-linked Charcot-Marie-Tooth neuropathy shown by brain stem auditory evoked responses. (8676158)
1996
37
Operative treatment of medical epicondylitis. Influence of concomitant ulnar neuropathy at the elbow. (7608229)
1995
38
Three subgroups of patients from the United Kingdom with Leber hereditary optic neuropathy. (7821467)
1994
39
Late onset dysthyroid optic neuropathy. (7920007)
1994
40
Acute intermittent porphyria with atypical neuropathy. (2035100)
1991
41
Sparing of the flexor carpi ulnaris in ulnar neuropathy at the elbow. (1656251)
1991
42
Risk factors in nonarteritic anterior ischemic optic neuropathy. (2077825)
1990
43
Acute femoral neuropathy and iliopsoas infarction in intravenous drug abusers. (2166251)
1990
44
Membranous glomerulonephritis associated with chronic progressive demyelinating neuropathy. (3027615)
1987
45
Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy. (3742831)
1986
46
Axonal dystrophy in experimental diabetic autonomic neuropathy. (7160544)
1982
47
A new test to study diabetic autonomic neuropathy. (7227703)
1981
48
Hormonal, metabolic, and cardiovascular responses to hypoglycemia in diabetic autonomic neuropathy. (7018967)
1981
49
Nerve xenografts to apportion the role of axon and Schwann cell in myelinated fiber absence in hereditary sensory neuropathy, type II. (289909)
1979
50
9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy. (1094320)
1975

Variations for Neuropathy

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Expression for genes affiliated with Neuropathy

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Expression patterns in normal tissues for genes affiliated with Neuropathy

Search GEO for disease gene expression data for Neuropathy.

Pathways for genes affiliated with Neuropathy

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Pathways related to Neuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0SPTLC1, SPTLC2
29.9GJB1, MPZ, PMP22

Compounds for genes affiliated with Neuropathy

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Sources:
44Novoseek, 61Tocris Bioscience, 28IUPHAR, 24HMDB, 11DrugBank
See all sources

Compounds related to Neuropathy according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1mipafox4410.2NGF, PNPLA6
22,3-cyclic nucleotide4410.2PNPLA6, MPZ
3dihydroprogesterone4410.2PMP22, MPZ
4l-serine61 28 24 1113.1SPTLC2, SPTLC1
53-Dehydrosphinganine2410.0SPTLC1, SPTLC2
6ganglioside4410.0PMP22, NGF, MPZ
7dihydrotestosterone44 28 24 1112.9MPZ, NGF, PMP22
8ceramide449.8NGF, SPTLC1, SPTLC2
9gaba449.6GARS, GJB1, PMP22
10cysteine449.3PMP22, NGF, MPZ, GJB1, GARS
11tyrosine449.0NGF, MPZ, WNK1, MTMR2, GJB1, GARS
12serine448.8GARS, SPTLC2, SPTLC1, PNPLA6, PMP22, NGF

GO Terms for genes affiliated with Neuropathy

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Cellular components related to Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine C-palmitoyltransferase complexGO:01705910.0SPTLC1, SPTLC2

Biological processes related to Neuropathy according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1sphinganine biosynthetic processGO:04651110.2SPTLC1, SPTLC2
2sphingomyelin biosynthetic processGO:00668610.2SPTLC1, SPTLC2
3sphingosine biosynthetic processGO:04651210.2SPTLC2, SPTLC1
4ceramide biosynthetic processGO:04651310.1SPTLC1, SPTLC2
5myelin assemblyGO:03228810.1MTMR2, PMP22
6neuron developmentGO:04866610.0MTMR2, WNK1
7negative regulation of neuron projection developmentGO:0109779.9PMP22, TRPV4
8peripheral nervous system developmentGO:0074229.9NGF, PMP22
9sphingolipid biosynthetic processGO:0301489.7SPTLC1, SPTLC2
10cell deathGO:0082198.9TRPV4, PNPLA6, MFN2, KIF1A, GARS, GAN

Molecular functions related to Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine C-palmitoyltransferase activityGO:00475810.0SPTLC1, SPTLC2

Products for genes affiliated with Neuropathy

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  • Antibodies
  • Proteins
  • Lysates

Sources for Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet