MCID: NRP001
MIFTS: 57

Neuropathy

Categories: Neuronal diseases, Immune diseases, Rare diseases

Aliases & Classifications for Neuropathy

MalaCards integrated aliases for Neuropathy:

Name: Neuropathy 12 14 69
Peripheral Neuropathy 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:870
ICD10 33 G62.9
NCIt 47 C4731
UMLS 69 C0442874

Summaries for Neuropathy

Disease Ontology : 12 A nervous system disease that is located in nerves or nerve cells.

MalaCards based summary : Neuropathy, also known as peripheral neuropathy, is related to neuropathy, recurrent, with pressure palsies and hereditary motor and sensory neuropathy via, and has symptoms including back pain, headache and neuralgia. An important gene associated with Neuropathy is IARS2 (Isoleucyl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways is Neural Crest Differentiation. The drugs Pregabalin and Stavudine have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and skin, and related phenotypes are behavior/neurological and cellular

Related Diseases for Neuropathy

Diseases in the Neuropathy family:

Autoimmune Neuropathy Hereditary Type 1 Neuropathy
Hereditary Type 2 Neuropathy Hereditary Neuropathies

Diseases related to Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1288)
id Related Disease Score Top Affiliating Genes
1 neuropathy, recurrent, with pressure palsies 34.4 GDAP1 GJB1 MPZ PMP22
2 hereditary motor and sensory neuropathy via 34.4 MFN2 SLC25A46
3 neuropathy, congenital hypomyelinating 34.1 GDAP1 GJB1 MFN2 MPZ PMP22 SLC12A6
4 dejerine-sottas disease 33.9 GDAP1 GJB1 MPZ PMP22
5 charcot-marie-tooth disease, type 1b 33.9 GJB1 MPZ PMP22
6 charcot-marie-tooth neuropathy type 4j 33.8 GJB1 MPZ PMP22
7 charcot-marie-tooth neuropathy x 33.8 GDAP1 GJB1 MPZ PMP22
8 neuropathy, inflammatory demyelinating 33.6 GDAP1 GJB1 MFN2 MPZ PMP22
9 charcot-marie-tooth disease, type 1e 33.5 GDAP1 GJB1 MFN2 MPZ PMP22
10 charcot-marie-tooth disease, type 1f 33.1 GAN GDAP1 GJB1 MFN2 MPZ PMP22
11 charcot-marie-tooth disease, axonal, with vocal cord paresis 32.2 GDAP1 TDP1
12 cerebellar ataxia, deafness, and narcolepsy, autosomal dominant 32.0 SPTLC1 SPTLC2
13 behr syndrome 31.8 MFN2 MT-ND4 SLC25A46
14 hypoxia 30.6 GJB1 MFN2 MPZ PMP22
15 status epilepticus 30.1 MPZ MT-ND4 PMP22
16 diffuse large b-cell lymphoma 30.0 MPZ NGF PMP22
17 neuropathy, hereditary sensory and autonomic, type ii 12.1
18 nonarteritic anterior ischemic optic neuropathy 12.1
19 neuropathy, hereditary sensory, type ie 12.1
20 diabetic neuropathy 12.1
21 agenesis of the corpus callosum with peripheral neuropathy 12.1
22 neuromyotonia and axonal neuropathy, autosomal recessive 12.0
23 giant axonal neuropathy 12.0
24 hereditary neuropathies 12.0
25 autonomic neuropathy 12.0
26 multifocal motor neuropathy 12.0
27 charcot-marie-tooth neuropathy, x-linked dominant, 1 12.0
28 neuropathy, hereditary sensory and autonomic, type v 12.0
29 neuropathy, hereditary motor and sensory, russe type 12.0
30 spinocerebellar ataxia, autosomal recessive with axonal neuropathy 12.0
31 neuropathy, hereditary sensory and autonomic, type vii 12.0
32 peripheral neuropathy, myopathy, hoarseness, and hearing loss 12.0
33 auditory neuropathy 12.0
34 neuropathy, hereditary sensory and autonomic, type vi 12.0
35 hereditary motor and sensory neuropathy, type iic 12.0
36 congenital cataracts, facial dysmorphism, and neuropathy 12.0
37 ulnar neuropathy 12.0
38 neuropathy, hereditary sensory and autonomic, type ia 11.9
39 neuropathy, hereditary, with or without age-related macular degeneration 11.9
40 hereditary motor and sensory neuropathy v 11.9
41 auditory neuropathy, autosomal dominant, 1 11.9
42 spastic paraplegia, optic atrophy, and neuropathy 11.9
43 hereditary neuropathy with liability to pressure palsy 11.9
44 hereditary motor and sensory neuropathy, okinawa type 11.9
45 sensory peripheral neuropathy 11.9
46 neuropathy, hereditary sensory, with spastic paraplegia 11.9
47 neuropathy, hereditary sensory and autonomic, type i, with cough and gastroesophageal reflux 11.9
48 giant axonal neuropathy 2, autosomal dominant 11.9
49 neuropathy, ataxia, and retinitis pigmentosa 11.9
50 neuropathy, hereditary motor and sensory, type vib 11.9

Graphical network of the top 20 diseases related to Neuropathy:



Diseases related to Neuropathy

Symptoms & Phenotypes for Neuropathy

UMLS symptoms related to Neuropathy:


back pain, headache, neuralgia, pain, sciatica, seizures, syncope, tremor, chronic pain, atypical facial pain, neurologic symptoms, vertigo/dizziness, sleeplessness, hemiparesis

MGI Mouse Phenotypes related to Neuropathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 GAN GDAP1 GJB1 MFN2 MPZ NGF
2 cellular MP:0005384 10.18 DIAPH3 GAN GDAP1 GJB1 HINT1 MFN2
3 growth/size/body region MP:0005378 10.1 MFN2 NGF PMP22 PNPLA6 POLG SLC12A6
4 homeostasis/metabolism MP:0005376 10.07 GJB1 HINT1 MFN2 MPZ NGF PNPLA6
5 mortality/aging MP:0010768 9.93 MPZ NGF PMP22 PNPLA6 POLG SPTLC1
6 muscle MP:0005369 9.5 GAN MFN2 NGF PMP22 POLG SLC12A6
7 nervous system MP:0003631 9.47 WNK1 GAN GDAP1 GJB1 MFN2 MPZ

Drugs & Therapeutics for Neuropathy

Drugs for Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 864)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 148553-50-8 5486971
2
Stavudine Approved, Investigational Phase 4,Phase 3 3056-17-5 18283
3
Isosorbide Dinitrate Approved Phase 4,Phase 3 87-33-2 6883
4
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068
5
Dorzolamide Approved Phase 4 120279-96-1 3154 5284549
6
Timolol Approved Phase 4,Phase 3,Phase 1 26839-75-8 33624 5478
7
Fexofenadine Approved Phase 4 83799-24-0 3348
8
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2 60142-96-3 3446
9
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
10
Acetaminophen Approved Phase 4,Phase 3,Phase 2 103-90-2 1983
11
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
12
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
13
Aztreonam Approved Phase 4,Phase 2 78110-38-0 5362041 5742832
14
Clindamycin Approved, Vet_approved Phase 4,Phase 2 18323-44-9 29029
15
Levofloxacin Approved, Investigational Phase 4,Phase 2,Phase 3 100986-85-4 149096
16
Linezolid Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 165800-03-3 441401
17
Metronidazole Approved Phase 4,Phase 2 443-48-1 4173
18
Ofloxacin Approved Phase 4,Phase 2,Phase 3 82419-36-1 4583
19
Piperacillin Approved Phase 4,Phase 3,Phase 2 66258-76-2 43672
20
Tazobactam Approved Phase 4,Phase 3,Phase 2 89786-04-9 123630
21
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2 13422-51-0 11953898 5460373 44475014
22
Nabilone Approved, Investigational Phase 4,Phase 3 51022-71-0 5284592
23
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
24
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
25
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
26
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 216974-75-3
27
Carboplatin Approved Phase 4,Phase 3,Phase 1,Phase 2 41575-94-4 10339178 498142 38904
28
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
29
Travoprost Approved Phase 4,Phase 3 157283-68-6 5282226
30
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 83-43-2 6741
31
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-24-8 5755
32
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
33
Fluorouracil Approved Phase 4,Phase 2,Phase 3,Phase 1 51-21-8 3385
34
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
35
Bupivacaine Approved, Investigational Phase 4,Phase 2,Early Phase 1 2180-92-9, 38396-39-3 2474
36
Ciprofloxacin Approved, Investigational Phase 4,Phase 2,Phase 1 85721-33-1 2764
37
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
38
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
39
Ephedrine Approved Phase 4,Phase 1 299-42-3 9294
40
Pseudoephedrine Approved Phase 4,Phase 1 90-82-4 7028
41
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 1 50-78-2 2244
42
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
43
Saxagliptin Approved Phase 4 361442-04-8 11243969
44
Gemcitabine Approved Phase 4,Phase 3,Phase 2,Phase 1 95058-81-4 60750
45
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
46
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
47
Tramadol Approved, Investigational Phase 4,Phase 3 27203-92-5 33741
48
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
49
4-Aminopyridine Approved Phase 4 504-24-5 1727
50
Carbidopa Approved Phase 4,Phase 3,Phase 2 28860-95-9 34359 38101

Interventional clinical trials:

(show top 50) (show all 2067)

id Name Status NCT ID Phase Drugs
1 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy Unknown status NCT00123136 Phase 4
2 Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy Unknown status NCT01770964 Phase 4 Pregabalin;placebo
3 Omega-3 Fatty Acids and Chemotherapy-induced Neuropathy and Inflammation in Breast Cancer Unknown status NCT01049295 Phase 4
4 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
5 Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY Unknown status NCT00235222 Phase 4 stavudine
6 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
7 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
8 Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences. Unknown status NCT02033057 Phase 4
9 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4 Timolol & Dorzolamide
10 Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
11 IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia Unknown status NCT02504996 Phase 4 Paracetamol;morphine;Placebo
12 Efficacy and Safety of Garamycin® Sponge (Gentamicin-Collagen Sponge) in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection Unknown status NCT01951768 Phase 4 Garamycin Sponge (Gentamicin-Collagen sponge);Systemic Antibiotic
13 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
14 Safety and Efficacy of Mecobalamin Injection in Peripheral Neuropathies Patients (Study JGAZSY091109) Completed NCT01192113 Phase 4 Mecobalamin IV Injection;Mecobalamin IM injection;Mecobalamin IV or IM injection
15 The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy Completed NCT02056366 Phase 4 α-lipoic acid
16 Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study Completed NCT00614341 Phase 4
17 Frequency Modulated Neural Stimulation (FREMS) in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
18 A Randomized Double-Blind Study Testing the Effects of Pregabalin on Diabetic Neuropathy Completed NCT00573261 Phase 4 Pregabalin;Placebo
19 Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN) Completed NCT00726713 Phase 4
20 A Study on the Efficacy and Safety of Gabapentin in the Treatment of Patients With Painful Diabetic Neuropathy Completed NCT00644748 Phase 4 gabapentin
21 A Study to Compare Safety and Efficacy of Tramadol Hydrochloride/Acetaminophen With Gabapentin in Participants With Diabetic Neuropathy Completed NCT00634543 Phase 4 Tramadol hydrochloride/ Acetaminophen;Gabapentin
22 Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Diabetic Peripheral Neuropathy Completed NCT00380913 Phase 4 Cesamet™ (nabilone)
23 Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
24 Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy Completed NCT00159679 Phase 4 Pregabalin
25 A Study To Evaluate Pregabalin In Patients With Painful Diabetic Peripheral Neuropathy (DPN) Completed NCT00156078 Phase 4 pregabalin
26 Anodyne Therapy in Diabetic Sensory Neuropathy Completed NCT00120341 Phase 4
27 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
28 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
29 A Study of the Efficacy and Safety of Pregabalin for the Treatment of Diabetic Peripheral Neuropathy or Postherpetic Neuralgia Completed NCT00629681 Phase 4 Pregabalin
30 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
31 Safety of Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy Completed NCT00159731 Phase 4 Pregabalin
32 Evaluation of Rocker sOles in Diabetis Completed NCT02891928 Phase 4
33 A Study of the Effectiveness And Safety Of Lidoderm® As Add-On Treatment in Patients With Postherpetic Neuralgia, Diabetic Neuropathy, or Low Back Pain Completed NCT00904020 Phase 4 Lidoderm
34 Alpha Lipoic Acid for Treatment of Diabetic Neuropathy Completed NCT02439879 Phase 4 Alpha lipoic acid
35 Autonomic Nervous System Dysfunction and Peripheral Neuropathy in a Cohort of Asymptomatic Juvenile Diabetic Patients (Type I): A Case-Controlled Study Completed NCT00466778 Phase 4
36 A Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy (CIPN) Completed NCT01675531 Phase 4 Targin
37 Lidoderm® (Lidocaine Patch 5%) in Diabetic and Idiopathic Neuropathy Completed NCT00903851 Phase 4 Lidoderm
38 Clinical Study for Assessment of the Efficacy of Gabapentin (Carbatin and Neurontin) in Patients With Neuropathy Pain Completed NCT02074267 Phase 4 Carbatin;Neurontin
39 Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Chemotherapy-Induced Neuropathy Completed NCT00380965 Phase 4 Cesamet™ (nabilone)
40 Efficacy and Tolerability of Carbamazepine CR in Diabetic Neuropathy Pain Completed NCT01089855 Phase 4 Carbamazepine
41 Maintenance of Effect of Duloxetine in Patients With Diabetic Peripheral Neuropathic Pain (DPNP) Completed NCT00322621 Phase 4 Duloxetine
42 Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management Completed NCT01364298 Phase 4 Gabapentin/B-complex;Pregabalin
43 Training "Pain Connoisseurs" for Efficient Analgesic Proof-of-Concept Studies Completed NCT02842554 Phase 4 Drug Placebo Administration
44 An Open Label, Dose Finding Trial of Viagra for the Treatment of Neuropathic Pain (in Diabetes Mellitus) Completed NCT00194909 Phase 4 sildenafil (Viagra)
45 Pregabalin Treatment Of Peripheral Neuropathic Pain Associated With Diabetic Peripheral NeP (DPN), Postherpetic Neuralgia (PHN), HIV-related NeP (HIV), and Chemotherapy Induced NeP Completed NCT00407511 Phase 4 Pregabalin
46 Asian Study on Cilostazol Effectivity in Neuropathies of Diabetes Mellitus Type 2-A Pilot Study in the Philippines Completed NCT01076478 Phase 4 Cilostazol
47 Lovaza® and Microvascular Function in Type 2 Diabetes Completed NCT00931879 Phase 4 omega-3-ethyl esters;Placebo
48 Effect of Arginine on Microcirculation in Patients With Diabetes Completed NCT00902616 Phase 4
49 Tolerability of Switching to Duloxetine for the Management of Diabetic Nerve Pain Completed NCT00266643 Phase 4 duloxetine hydrochloride
50 An Open-Label Comparison of Duloxetine to Other Alternatives for the Management of Diabetic Peripheral Neuropathic Pain Completed NCT00385671 Phase 4 duloxetine hydrochloride;pregabalin;gabapentin

Search NIH Clinical Center for Neuropathy

Genetic Tests for Neuropathy

Anatomical Context for Neuropathy

MalaCards organs/tissues related to Neuropathy:

39
Breast, Testes, Skin, Heart, Bone, Eye, Lung

Publications for Neuropathy

Articles related to Neuropathy:

(show top 50) (show all 8299)
id Title Authors Year
1
Long-term Peripheral Neuropathy in Breast Cancer Patients Treated With Adjuvant Chemotherapy: NRG Oncology/NSABP B-30. ( 28954297 )
2018
2
Chemotherapy-Associated Peripheral Neuropathy in Patients With Early-Stage Breast Cancer: A Systematic Review. ( 28954296 )
2018
3
Variable phenotypic expression and onset in MYH14 distal hereditary motor neuropathy phenotype in a large, multigenerational North American family. ( 27875632 )
2017
4
Peripheral Neuropathy and Nerve Compression Syndromes in Burns. ( 28888304 )
2017
5
Late-onset Hirayama disease presenting with ulnar neuropathy: A case report. ( 28839321 )
2017
6
Teaching NeuroImages: Early-onset dementia and demyelinating neuropathy disclosing cerebrotendinous xanthomatosis. ( 28894038 )
2017
7
Visual field improvement in non-arteritic posterior ischemic optic neuropathy in a patient treated with intravenous prostaglandin E1 and steroids. ( 28867757 )
2017
8
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy: Response. ( 28759500 )
2017
9
The quest for more research on painful diabetic neuropathy. ( 28942323 )
2017
10
MCM3AP in recessive Charcot-Marie-Tooth neuropathy and mild intellectual disability. ( 28633435 )
2017
11
Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy. ( 28880907 )
2017
12
Quantitative muscle ultrasound as a biomarker in Charcot-Marie-Tooth neuropathy. ( 27940147 )
2017
13
Leber's Hereditary Optic Neuropathy-Specific Mutation m.11778G>A Exists on Diverse Mitochondrial Haplogroups in India. ( 28768321 )
2017
14
TNF-Alpha in Peripheral Neuropathy Patients with Impaired Glucose Regulation. ( 28251164 )
2017
15
Vitreous amyloidosis with autonomic neuropathy of the digestive tract associated with a novel transthyretin p.Gly87Arg variant in a Bangladeshi patient: a case report. ( 28802308 )
2017
16
Acute painful autoimmune neuropathy: A variant of Guillain-BarrAc syndrome. ( 28667708 )
2017
17
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective CohortA Study. ( 28063480 )
2017
18
Choroidal thickness in traumatic optic neuropathy. ( 28937859 )
2017
19
Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese. ( 28447211 )
2017
20
Chronic encephalopathy with ataxia, myoclonus, and auditory neuropathy: A case of bismuth poisoning. ( 28084272 )
2017
21
Causally treatable, hereditary neuropathies in Fabry's disease, transthyretin-related familial amyloidosis, and Pompe's disease. ( 28295152 )
2017
22
Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy. ( 28719619 )
2017
23
Ankle-brachial index and diabetic neuropathy: study of 225 patients. ( 28813083 )
2017
24
High-dose Ig VENA is well tolerated and efficacious in patients with multifocal motor neuropathy. ( 28144763 )
2017
25
Median and common peroneal neuropathy in coir workers of Alappuzha district, Kerala. ( 28298838 )
2017
26
Smoking and Eye Pathologies. A systemic review. Part II. Retina diseases, uveitis, optic neuropathies, thyroid-associated orbitopathy. ( 28078992 )
2017
27
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28759499 )
2017
28
Clinical Characteristics and Treatment Response of Peripheral Neuropathy in the Presence of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Experience at a Single Tertiary Center. ( 28079316 )
2017
29
Auditory Neuropathy after Damage to Cochlear Spiral Ganglion Neurons in Mice Resulting from Conditional Expression of Diphtheria Toxin Receptors. ( 28743950 )
2017
30
Plantar fascia enthesopathy is highly prevalent in diabetic patients without peripheral neuropathy and correlates with retinopathy and impaired kidney function. ( 28358891 )
2017
31
Modiolar ossification in paediatric patients with auditory neuropathy. ( 28502273 )
2017
32
Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study. ( 28858986 )
2017
33
Autoimmunity, Autonomic Neuropathy, and the HPV Vaccination: A Vulnerable Subpopulation. ( 28868890 )
2017
34
Continuous glucose monitoring adds information beyond HbA1c in well-controlled diabetes patients with early cardiovascular autonomic neuropathy. ( 28728915 )
2017
35
Dalfampridine Treatment in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28538037 )
2017
36
Diabetic Neuropathy Evaluated by a Novel Device: Sural Nerve Conduction Is Associated with Glycemic Control and Ankle-Brachial Pressure Index in Japanese Patients with Diabetes. ( 28861044 )
2017
37
Nerve ultrasound as follow-up tool in treated multifocal motor neuropathy. ( 28681489 )
2017
38
Genetic Prion Disease Caused by PRNP Q160X Mutation Presenting with an Orbitofrontal Syndrome, Cyclic Diarrhea, and Peripheral Neuropathy. ( 27716661 )
2017
39
Bilateral Femoral Neuropathy Following Psoas Muscle Hematomas Caused by Enoxaparin Therapy. ( 28848224 )
2017
40
Recessive dystrophic epidermolysis bullosa results in painful small fibre neuropathy. ( 28369282 )
2017
41
Diphenyleneiodonium Mitigates Bupivacaine-Induced Sciatic Nerve Damage in a Diabetic Neuropathy Rat Model by Attenuating Oxidative Stress. ( 28682956 )
2017
42
Longitudinal study of neuropathy, microangiopathy, and autophagy in sural nerve: Implications for diabetic neuropathy. ( 28828222 )
2017
43
Sciatic neuropathy: findings on magnetic resonance neurography. ( 28670031 )
2017
44
Motor unit remodelling in multifocal motor neuropathy: The importance of axonal loss. ( 28837908 )
2017
45
The rare ethambutol-induced optic neuropathy: A case-report and literature review. ( 28079833 )
2017
46
Neurophthalmological conditions mimicking glaucomatous optic neuropathy: analysis of the most common causes of misdiagnosis. ( 28073365 )
2017
47
Brachial Plexitis (Parsonage Turner Syndrome, Brachial Neuropathy, Brachial Radiculitis) ( 28846332 )
2017
48
A Case of Auditory Neuropathy Caused by Pontine Hemorrhage in an Adult. ( 28704898 )
2017
49
Multifocal Choroiditis with Retinal Vasculitis, Optic Neuropathy, and Keratoconus in a Young Saudi Male. ( 28936058 )
2017
50
Automated Evaluation of Choroidal Thickness and Minimum Rim Width Thickness in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28885450 )
2017

Variations for Neuropathy

ClinVar genetic disease variations for Neuropathy:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 NEFL NM_006158.4(NEFL): c.64C> T (p.Pro22Ser) single nucleotide variant Pathogenic/Likely pathogenic rs28928910 GRCh37 Chromosome 8, 24813966: 24813966
2 IARS2 NM_018060.3(IARS2): c.2726C> T (p.Pro909Leu) single nucleotide variant Pathogenic rs587783070 GRCh38 Chromosome 1, 220143109: 220143109

Copy number variations for Neuropathy from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 107544 17 15900000 22100000 Microdeletion Neuropathy
2 107574 17 16000000 22200000 Copy number Neuropathy
3 216423 6 92100000 98700000 Microdeletion EPHA7 Neuropathy

Expression for Neuropathy

Search GEO for disease gene expression data for Neuropathy.

Pathways for Neuropathy

Pathways related to Neuropathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.81 GJB1 MPZ PMP22

GO Terms for Neuropathy

Cellular components related to Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.5 GDAP1 IARS2 MFN2 MT-ND4 POLG SLC25A46
2 serine C-palmitoyltransferase complex GO:0017059 8.62 SPTLC1 SPTLC2

Biological processes related to Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ceramide biosynthetic process GO:0046513 9.37 SPTLC1 SPTLC2
2 mitochondrial fusion GO:0008053 9.32 GDAP1 MFN2
3 sphingosine biosynthetic process GO:0046512 9.26 SPTLC1 SPTLC2
4 sphingomyelin biosynthetic process GO:0006686 9.16 SPTLC1 SPTLC2
5 positive regulation of lipophagy GO:1904504 8.96 SPTLC1 SPTLC2
6 sphinganine biosynthetic process GO:0046511 8.62 SPTLC1 SPTLC2

Molecular functions related to Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine C-palmitoyltransferase activity GO:0004758 8.62 SPTLC1 SPTLC2

Sources for Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42