MCID: NRP001
MIFTS: 54

Neuropathy malady

Summaries for Neuropathy

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may affect sensation, movement,... more...

MalaCards: Neuropathy is related to autonomic neuropathy and brachial plexus neuropathy. An important gene associated with Neuropathy is GJB1 (gap junction protein, beta 1, 32kDa), and among its related pathways is Neural Crest Differentiation. The compounds serine and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include nerves or nerve cells, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A nervous system disease that is located in nerves or nerve cells.

Aliases & Classifications for Neuropathy

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

neuropathy 8 10 61


External Ids:

Disease Ontology8 DOID:870
NCIt40 C4731

Related Diseases for Neuropathy

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1005)
idRelated DiseaseScoreTop Affiliating Genes
1autonomic neuropathy31.6NGF
2brachial plexus neuropathy30.9MPZ, PMP22
3hereditary neuropathies30.9PMP22, MPZ, MTMR2, PRX, GJB1
4tooth disease30.9PMP22, MPZ, GJB1
5sensory peripheral neuropathy30.7GJB1, SLC12A6, SPTLC1, GDAP1, NGF, PRX
6hereditary neuropathy with liability to pressure palsies30.6PMP22
7motor peripheral neuropathy30.6MPZ, PMP22
8charcot-marie-tooth neuropathy type 130.4NEFL, MPZ, PMP22
9chronic inflammatory demyelinating polyradiculoneuropathy30.2PMP22, MPZ
10charcot-marie-tooth disease type 4e30.1PMP22, MPZ
11charcot-marie-tooth neuropathy type 230.1MFN2, GARS, MPZ, NEFL, GDAP1
12charcot-marie-tooth disease type 330.0PMP22, MPZ, GJB1
13neuropathy, recurrent, with pressure palsies30.0PMP22, CMT1A
14charcot-marie-tooth neuropathy type 429.8GDAP1, PRX, MTMR2
15charcot-marie-tooth neuropathy type 1a29.8MPZ, PMP22
16neuroaxonal dystrophy29.8GAN
17pelizaeus-merzbacher disease29.7MPZ
18charcot-marie-tooth disease type 1e29.5PMP22, CMT1A
19charcot-marie-tooth disease type 1a29.5PMP22, CMT1A
20ischemic neuropathy11.0
21ischemic optic neuropathy11.0
22diabetic autonomic neuropathy11.0
23axonal neuropathy10.9
24optic neuropathy, anterior ischemic10.9
25n syndrome10.9
26leber hereditary optic neuropathy10.9
27ulnar neuropathy10.9
28multifocal motor neuropathy10.9
29auditory neuropathy10.9
30femoral neuropathy10.8
31nonarteritic anterior ischemic optic neuropathy10.7
32giant axonal neuropathy10.7
33small fiber neuropathy10.7
34amyloid neuropathy10.7
35sciatic neuropathy10.6
36acute motor axonal neuropathy10.6
37peroneal neuropathy10.6
38median neuropathy10.6
39ataxia10.6
40uremic neuropathy10.5
41alcoholic neuropathy10.5
42toxic optic neuropathy10.5
43charcot-marie-tooth hereditary neuropathy10.5
44autonomic peripheral neuropathy10.5
45distal hereditary motor neuropathy10.4
46hereditary sensory and autonomic neuropathy type ii10.4
47neuropathy, inflammatory demyelinating10.4
48dnmt1-related dementia, deafness, and sensory neuropathy10.4
49guillain-barr� syndrome10.4
50neuropathy hereditary sensory and autonomic type 110.4

Graphical network of the top 20 diseases related to Neuropathy:



Diseases related to neuropathy

Clinical Features for Neuropathy

Drugs & Therapeutics for Neuropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Neuropathy

Drug clinical trials:

Search ClinicalTrials for Neuropathy

Search NIH Clinical Center for Neuropathy

Search CenterWatch for Neuropathy

Genetic Tests for Neuropathy

Anatomical Context for Neuropathy

Sources:
14FMA
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FMA organs/tissues related to Neuropathy:

14
Nerves or nerve cells

Animal Models for Neuropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Neuropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363112.9NGF, MPZ, NEFL, MTMR2, PRX, TRPV4
2MP:000538612.5MFN2, GJB1, GAN, GARS, MPZ, NGF
3MP:001076812.2PNPLA6, PMP22, MFN2, GAN, GARS, MPZ
4MP:000537811.9MFN2, GAN, GARS, MTMR2, PRX, NGF
5MP:000536911.6MFN2, GAN, GARS, TRPV4, NGF, WNK1

Publications for Neuropathy

Sources:
51PubMed
See all sources

Articles related to Neuropathy:

(show top 50)    (show all 6577)
idTitleAuthorsYear
1
Analgesic effects of mad honey (grayanotoxin) in mice models of acute pain and painful diabetic neuropathy. (23584354)
2014
2
Supraorbital nerve entrapment neuropathy in Hansen's disease. (23856804)
2013
3
Thiamine-deficient optic neuropathy associated with Wernicke's encephalopathy in patients with chronic diarrhea. (23473530)
2013
4
Hereditary neuropathy with liability to pressure palsies occurring during military training. (22545374)
2012
5
Peripheral neuropathy in hereditary spastic paraplegia due to spastin (SPG4) mutation--a neurophysiological study using excitability techniques. (22192498)
2012
6
Ulnar neuropathy at the wrist in a patient with carpal tunnel syndrome after open carpal tunnel release. (22639758)
2012
7
Diagnostic accuracy of heart-rate recovery after exercise in the assessment of diabetic cardiac autonomic neuropathy. (22671998)
2012
8
Accuracy of in-office nerve conduction studies for median neuropathy: a meta-analysis. (21131139)
2011
9
Anterior temporal chordoid meningioma causing compressive optic neuropathy. (21358445)
2011
10
Interaction between adalimumab with concurrent pregabalin and duloxetine administration in a psoriasis patient with diabetic peripheral neuropathy. (21699129)
2011
11
Date fruit extract is a neuroprotective agent in diabetic peripheral neuropathy in streptozotocin-induced diabetic rats: a multimodal analysis. (22191015)
2011
12
Efficacy and safety of lacosamide in painful diabetic neuropathy. (20067958)
2010
13
A novel robotic monofilament test for diabetic neuropathy. (21377106)
2010
14
The effect of pregabalin on pain-related sleep interference in diabetic peripheral neuropathy or postherpetic neuralgia: a review of nine clinical trials. (20812792)
2010
15
Cardiovascular autonomic neuropathy, HDL cholesterol, and smoking correlate with arterial stiffness markers determined 18 years later in type 1 diabetes. (20040653)
2010
16
Evaluation of serum levels of SOD and MDA in patients with Leber's hereditary optic neuropathy carrying the mitochondrial DNA G11778A mutation]. (20021885)
2009
17
Molecular cloning and expression analysis of cDNA ends of chicken neuropathy target esterase. (18191825)
2008
18
Bilateral tonic pupils: Holmes Adie syndrome or generalised neuropathy? (17584996)
2007
19
Unilateral pudendal neuropathy is common in patients with fecal incontinence. (17279299)
2007
20
Encephalopathy and severe neuropathy due to probable systemic vasculitis as an initial manifestation of mixed connective tissue disease. (16679652)
2006
21
Peripheral neuropathy in Krabbe disease: electrodiagnostic findings. (16864819)
2006
22
Dominant LMNA mutations can cause combined muscular dystrophy and peripheral neuropathy. (15965218)
2005
23
Impairment of Trk-neurotrophin receptor by the serum of a patient with subacute sensory neuropathy. (16216947)
2005
24
Clinical, electrodiagnostic, and sonographic studies in ulnar neuropathy at the elbow. (15266636)
2004
25
Posterior antebrachial cutaneous nerve conduction study in radial neuropathy. (15337623)
2004
26
Expression analysis of the N-Myc downstream-regulated gene 1 indicates that myelinating Schwann cells are the primary disease target in hereditary motor and sensory neuropathy-Lom. (15474366)
2004
27
Evaluation of the patient with foot pain: when is the cause small-fiber neuropathy? (19078750)
2004
28
A prospective evaluation of phrenic nerve conduction in multifocal motor neuropathy and chronic inflammatory demyelinating polyneuropathy. (12929191)
2003
29
Bilateral simultaneous anterior ischemic optic neuropathy in a young, healthy man. (14609932)
2003
30
Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome. (14517542)
2003
31
Erythropoietin response to hypoxia in patients with diabetic autonomic neuropathy and non-diabetic chronic renal failure. (11869305)
2002
32
Secondary amyloidosis as a life-ending event in multifocal motor neuropathy. (11562923)
2001
33
Hereditary neuropathy with liability to pressure palsies is not a major cause of idiopathic carpal tunnel syndrome. (11594922)
2001
34
Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy. (11430802)
2001
35
Successful immunosuppressant therapy of severe progressive cerebellar degeneration and sensory neuropathy: a case report. (11018251)
2000
36
Neurotrophic factors in the therapy of diabetic neuropathy. (10484043)
1999
37
Congenital cataracts facial dysmorphism neuropathy (CCFDN) syndrome: a novel developmental disorder in Gypsies maps to 18qter. (10439962)
1999
38
The nuoM arg368his mutation in NADH:ubiquinone oxidoreductase from Rhodobacter capsulatus: a model for the human nd4-11778 mtDNA mutation associated with Leber's hereditary optic neuropathy. (9685604)
1998
39
Chronic relapsing axonal neuropathy responsive to intravenous immunoglobulin. (9191788)
1997
40
The two locus control of Leber hereditary optic neuropathy and a high penetrance in Japanese pedigrees. (8500789)
1993
41
Charcot-Marie-Tooth neuropathy type 1A with both duplication and non-duplication. (8099303)
1993
42
Giant axonal neuropathy in 2 siblings: a generalized disorder of intermediate filaments. (2015839)
1991
43
Humoral antibodies in immune mediated neuropathy]. (1966017)
1990
44
Rocky Mountain spotted fever and sensory neuropathy. (3025515)
1986
45
Brachial plexus neuropathy following high-dose cytarabine in acute monoblastic leukemia. (2992782)
1985
46
Familial neuropathy with dementia, retinitis pigmentosa, and dysautonomia. (3860747)
1985
47
Femoral neuropathy subsequent to abdominal hysterectomy. A comparative study. (3002881)
1985
48
Reduced sinus arrhythmia in diabetic autonomic neuropathy. (6404432)
1983
49
Haemodynamic changes during graded exercise in patients with diabetic autonomic neuropathy. (7095332)
1982
50
The optic neuropathy of pernicious anemia. (5344936)
1969

Genetic Variations for Neuropathy

Expression for genes affiliated with Neuropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuropathy

Search GEO for disease gene expression data for Neuropathy.

Pathways for genes affiliated with Neuropathy

Sources:
38NCBI BioSystems Database
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Pathways related to Neuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9GJB1, MPZ, PMP22

Compounds for genes affiliated with Neuropathy

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Neuropathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1serine4511.9SPTLC1, PMP22, GARS, MPZ, NGF, WNK1
2tyrosine4511.5MTMR2, GJB1, WNK1, NGF, TRPV4, MPZ
3glutamate4511.2MPZ, NEFL, NGF, GJB1, GARS
4ganglioside4511.1PMP22, MPZ, NGF
5mipafox4510.9NGF, PNPLA6
6dihydroprogesterone4510.9PMP22, MPZ
72,3-cyclic nucleotide4510.8PNPLA6, MPZ
8dihydrotestosterone45 29 11 2413.6MPZ, NGF, PMP22

GO Terms for genes affiliated with Neuropathy

Sources:
16Gene Ontology
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Cellular components related to Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurofilamentGO:00588310.8NEFL, GAN

Biological processes related to Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:00821911.3PNPLA6, GAN, GARS, OPTN, PRX, TRPV4
2negative regulation of neuron projection developmentGO:01097710.8TRPV4, PMP22
3myelin assemblyGO:03228810.5MTMR2, PMP22

Products for genes affiliated with Neuropathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neuropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet