MCID: NRP001
MIFTS: 61

Neuropathy malady

Neuronal diseases category

Summaries for Neuropathy

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may affect sensation, movement,... more...

MalaCards: Neuropathy is related to diabetic neuropathy and peripheral neuropathy. An important gene associated with Neuropathy is GJB1 (gap junction protein, beta 1, 32kDa), and among its related pathways is Neural Crest Differentiation. The compounds serine and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include nerves or nerve cells, testes and heart, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A nervous system disease that is located in nerves or nerve cells.

Aliases & Classifications for Neuropathy

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuropathy 8 10 60


External Ids:

Disease Ontology8 DOID:870
NCIt39 C4731

Related Diseases for Neuropathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1055)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic neuropathy31.8PMP22, MPZ, NGF
2peripheral neuropathy31.7WNK1, SLC12A6, SPTLC1
3autonomic neuropathy31.6NGF
4hereditary sensory neuropathy31.3SPTLC1, NGF
5hereditary neuropathy with liability to pressure palsies31.2PMP22
6brachial plexus neuropathy30.9MPZ, PMP22
7charcot-marie-tooth disease30.9PMP22, MPZ
8tooth disease30.8PMP22, MPZ, GJB1
9polyneuropathy30.8PMP22, GAN, MPZ, PRX, GJB1, PNPLA6
10sensory peripheral neuropathy30.7GJB1, SLC12A6, SPTLC1, GDAP1, NGF, PRX
11motor peripheral neuropathy30.6MPZ, PMP22
12paraplegia30.5PNPLA6
13neuritis30.5PMP22, MPZ
14charcot-marie-tooth neuropathy type 130.5NEFL, MPZ, PMP22
15myopathy30.5MPZ, GARS, MFN2, PMP22, NEFL, MTMR2
16hereditary neuropathies30.4PMP22, MPZ, MTMR2, PRX, GJB1
17charcot-marie-tooth neuropathy type 230.4MFN2, GARS, MPZ, NEFL, GDAP1
18polyradiculoneuropathy30.3PMP22
19charcot-marie-tooth disease type 4e30.2PMP22, MPZ
20chronic inflammatory demyelinating polyradiculoneuropathy30.1PMP22, MPZ
21charcot-marie-tooth disease type 330.1PMP22, MPZ, GJB1
22neuropathy, recurrent, with pressure palsies30.1PMP22, CMT1A
23charcot-marie-tooth neuropathy type 429.9GDAP1, PRX, MTMR2
24charcot-marie-tooth neuropathy type 1a29.8MPZ, PMP22
25charcot-marie-tooth disease type 1e29.8PMP22, CMT1A
26charcot-marie-tooth disease type 1a29.8PMP22, CMT1A
27neuroaxonal dystrophy29.8GAN
28pelizaeus-merzbacher disease29.6MPZ
29diabetic autonomic neuropathy11.0
30ischemic neuropathy11.0
31ischemic optic neuropathy11.0
32axonal neuropathy10.9
33ulnar neuropathy10.9
34leber hereditary optic neuropathy10.8
35femoral neuropathy10.8
36diabetes mellitus10.7
37giant axonal neuropathy10.7
38sciatic neuropathy10.6
39neuronitis10.6
40peroneal neuropathy10.6
41retinitis10.6
42alcoholic neuropathy10.5
43median neuropathy10.5
44uremic neuropathy10.5
45charcot-marie-tooth hereditary neuropathy10.5
46hereditary sensory and autonomic neuropathy type ii10.5
47toxic optic neuropathy10.5
48type 2 diabetes mellitus10.4
49autonomic peripheral neuropathy10.4
50distal hereditary motor neuropathy10.4

Graphical network of the top 20 diseases related to Neuropathy:



Diseases related to neuropathy

Clinical Features for Neuropathy

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Drugs & Therapeutics for Neuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Neuropathy

Drug clinical trials:

Search ClinicalTrials for Neuropathy

Search NIH Clinical Center for Neuropathy

Search CenterWatch for Neuropathy

Genetic Tests for Neuropathy

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Anatomical Context for Neuropathy

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Neuropathy:

32
Testes, Heart, Skin, Brain, Eye, Bone, Liver, Spinal cord, Breast, Endothelial, Lung, Thyroid, T cells, Colon, B cells, Kidney, Bone marrow, Dorsal root ganglion, Pituitary, Prostate, Skeletal muscle, Whole blood, Spleen, Pancreas, Tongue, Pancreatic islet, Cortex, Globus pallidus, Temporal lobe, Thalamus, Salivary gland, Small intestine, Smooth muscle, Amygdala, Monocytes, Lymph node, Trigeminal ganglion, Adrenal gland

FMA organs/tissues related to Neuropathy:

14
Nerves or nerve cells

Animal Models for Neuropathy or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363112.9NGF, MPZ, NEFL, MTMR2, PRX, TRPV4
2MP:000538612.5MFN2, GJB1, GAN, GARS, MPZ, NGF
3MP:001076812.2PNPLA6, PMP22, MFN2, GAN, GARS, MPZ
4MP:000537811.9MFN2, GAN, GARS, MTMR2, PRX, NGF
5MP:000536911.6MFN2, GAN, GARS, TRPV4, NGF, WNK1

Publications for Neuropathy

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Sources:
50PubMed
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Articles related to Neuropathy:

(show top 50)    (show all 6834)
idTitleAuthorsYear
1
Long-term evaluation of radiation-induced optic neuropathy after single-fraction stereotactic radiosurgery. (24074926)
2013
2
Phase 1/2 open-label dose-escalation study of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with painful diabetic peripheral neuropathy. (23609019)
2013
3
Peripheral neuropathy in multiple myeloma patients receiving lenalidomide, bortezomib, and dexamethasone (RVD) therapy. (23372151)
2013
4
Prevention of chemotherapy-induced peripheral neuropathy: a matter of personalized treatment? (23696616)
2013
5
Ethambutol optic neuropathy in a hemodialysis patient receiving a guideline-recommended dose. (24196753)
2013
6
Clinicopathological features of neuropathy in anti-neutrophil cytoplasmic antibody-associated vasculitis. (23385777)
2013
7
Exome sequencing reveals HINT1 mutations as a cause of distal hereditary motor neuropathy. (24105373)
2013
8
Exome sequencing identifies a REEP1 mutation involved in distal hereditary motor neuropathy type V. (22703882)
2012
9
Anti-ganglioside antibody internalization attenuates motor nerve terminal injury in a mouse model of acute motor axonal neuropathy. (22307327)
2012
10
Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy. (22285226)
2012
11
Acupuncture for chemotherapy-induced peripheral neuropathy (CIPN): a pilot study using neurography. (22146780)
2012
12
Clinical characteristics, pharmacotherapy, and healthcare resource use among patients with diabetic neuropathy newly prescribed pregabalin or gabapentin. (21435162)
2011
13
Hereditary motor sensory neuropathy (type 1) presenting with transient and persistent central nervous system manifestations: a novel genetic mutation. (21309765)
2011
14
Pulse wave analysis and cardiac autonomic neuropathy in type 1 diabetes: a report from the Pittsburgh Epidemiology of Diabetes Complications Study. (21819228)
2011
15
Acute motor axonal neuropathy cases in Van region. (21682081)
2011
16
Trigeminal motor neuropathy with tongue fasciculations in a patient with chronic inflammatory demyelinating polyradiculoneuropathy. (20615708)
2010
17
A role for omega-3 polyunsaturated fatty acid supplements in diabetic neuropathy. (19907026)
2010
18
Extreme efficacy of intravenous immunoglobulin therapy for severe burning pain in a patient with small fiber neuropathy associated with primary SjAPgren's syndrome. (19458906)
2009
19
New liquid intravenous immunoglobulin (10 % IVIg) for treatment of multifocal motor neuropathy: a prospective study of efficacy, safety and tolerability. (18758888)
2008
20
Vision loss following denileukin diftitox treatment: a case report of possible posterior ischemic optic neuropathy. (17454642)
2007
21
Lessons from the ischemic optic neuropathy decompression trial: a decade later. (17998522)
2007
22
Role of matrix metalloproteinases, proinflammatory cytokines, and oxidative stress-derived molecules in hepatitis C virus-associated mixed cryoglobulinemia vasculitis neuropathy. (17393409)
2007
23
Kiloh-Nevin syndrome: a compression neuropathy or brachial plexus neuritis? (17715720)
2007
24
Higher prevalence and severity of hepatic encephalopathy in patients with HCV cirrhosis and diabetes mellitus: is presence of autonomic neuropathy the missing part of the puzzle? (17032188)
2006
25
Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. (16237054)
2005
26
Anti-Hu antibodies, sensory neuropathy, and Holmes-Adie syndrome in a patient with seminoma. (15642929)
2005
27
Indolent herpetic whitlow of the toe in an elderly patient with diabetic neuropathy. (15347498)
2004
28
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
29
Demyelination and axonal loss in multifocal motor neuropathy: distribution and relation to weakness. (12477706)
2003
30
Recurrent visual loss in Leber hereditary optic neuropathy. (12583806)
2003
31
Optic neuropathy and macular chorioretinal folds caused by orbital cherubism. (12695257)
2003
32
Acute postural drop in optic nerve perfusion after vitrectomy and gas in a patient with diabetic autonomic neuropathy. (11914222)
2002
33
Giant axonal neuropathy (GAN): case report and two novel mutations in the gigaxonin gene. (11971098)
2002
34
Femoral neuropathy caused by reinforcement ring malposition and extruded bone-cement after revision total hip arthroplasty. (12066287)
2002
35
Incidence of cardiac autonomic neuropathy and its correlation with retinopathy, micro-albuminuria and glycated haemoglobin in non-insulin dependent diabetes mellitus. (12408270)
2002
36
Multifocal motor neuropathy presenting with respiratory failure. (11102916)
2000
37
The role of angiotensin converting enzyme and angiotensin II type 1 receptor gene polymorphisms in patients with nonarteritic anterior ischemic optic neuropathy. (10964835)
2000
38
Cardiovascular autonomic neuropathy (expiration and inspiration ratio) in type 1 diabetes. Incidence and predictors. (10925059)
2000
39
Autoimmunity in diabetic autonomic neuropathy: does the immune system get on your nerves? (9737800)
1998
40
Primary SjAPgren's syndrome presenting as autonomic neuropathy. Case report. (9852707)
1998
41
Nonarteritic anterior ischemic optic neuropathy. (9697375)
1998
42
Anterior ischemic optic neuropathy. (9292252)
1997
43
Femoral neuropathy after pelvic surgery. (7571234)
1995
44
Is all nondefinable optic atrophy Leber's hereditary optic neuropathy? (7801223)
1994
45
An example of Leber hereditary optic neuropathy not involving a mutation in the mitochondrial ND4 gene. (2121024)
1990
46
Protease activity in brain, nerve, and muscle of hens given neuropathy-inducing organophosphates and a calcium channel blocker. (2156356)
1990
47
Localized hypertrophic neuropathy--a rare and clinically almost unknown syndrome. (3791730)
1986
48
Alcoholic neuropathy associated with the eighth cranial nerve. (6867249)
1983
49
Acute porphyria presenting as peripheral neuropathy: case report. (6301802)
1982
50
Postoperative ulnar neuropathy. (7230449)
1981

Genetic Variations for Neuropathy

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Expression for genes affiliated with Neuropathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuropathy

Search GEO for disease gene expression data for Neuropathy.

Pathways for genes affiliated with Neuropathy

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37NCBI BioSystems Database
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Pathways related to Neuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9GJB1, MPZ, PMP22

Compounds for genes affiliated with Neuropathy

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Neuropathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1serine4411.9SPTLC1, PMP22, GARS, MPZ, NGF, WNK1
2tyrosine4411.5GARS, MPZ, MTMR2, TRPV4, NGF, WNK1
3glutamate4411.2GJB1, NGF, NEFL, MPZ, GARS
4ganglioside4411.1PMP22, MPZ, NGF
5mipafox4410.9PNPLA6, NGF
62,3-cyclic nucleotide4410.9MPZ, PNPLA6
7dihydroprogesterone4410.8PMP22, MPZ
8dihydrotestosterone44 28 11 2413.6PMP22, MPZ, NGF

GO Terms for genes affiliated with Neuropathy

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16Gene Ontology
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Cellular components related to Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurofilamentGO:00588310.8NEFL, GAN

Biological processes related to Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:00821911.3PNPLA6, GAN, GARS, OPTN, PRX, TRPV4
2negative regulation of neuron projection developmentGO:01097710.8TRPV4, PMP22
3myelin assemblyGO:03228810.5MTMR2, PMP22

Products for genes affiliated with Neuropathy

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  • Antibodies
  • Proteins
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Sources for Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet