Neuropathy malady

Wikipedia: Peripheral neuropathy is damage to nerves of the peripheral nervous system, which may be caused either...⁴⁴ more...

MalaCards: Neuropathy is related to neuronitis and peripheral neuropathy. An important gene associated with Neuropathy is GJB1 (gap junction protein, beta 1, 32kDa), and among its related pathways are Metabolic pathways and Oxidative phosphorylation. The compounds pioglitazone and rosiglitazone have been mentioned in the context of this disorder. Affiliated tissues include nerves or nerve cells, bone marrow and whole blood, and related mouse phenotypes are skeleton and behavior/neurological.

Disease Ontology: A nervous system disease that is located in nerves or nerve cells.⁶

Aliases & Descriptions:

neuropathy 6 7 8 43

Diseases related to neuropathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1281)

id	Related Disease	Score	Top Affiliating Genes
1	neuronitis	72.6	PICALM, PIK3C2A, NCAM1, PDE3B, REN, RETN
2	peripheral neuropathy	69.9	RETN, CNTF, CNTFR, CNTNAP1, KIF1B, RDPA
3	carcinoma	58.9	ZNF673, PIK3C2A, NCAM1, PDE3B, REN, RETN
4	pancreatitis	52.0	PIK3C2A, NCAM1, PDE3B, REN, RETN, CNR1
5	leukemia	49.9	ZNF673, PICALM, PIK3C2A, NCAM1, PDE3B, REN
6	diabetes mellitus	49.5	ZNF673, PIK3C2A, PDE3B, REN, RETN, CNR1
7	cerebritis	48.7	PIK3C2A, NCAM1, REN, CNR1, CNTF, VWF
8	alzheimer's disease	48.3	PION, PICALM, NCAM1, REN, CNR1, CNTF
9	retinitis	48.2	PIK3C2A, PDE3B, CNR1, CNTF, CNTFR, VWF
10	neuroblastoma	47.3	NCAM1, PDE3B, CNR1, CNTF, CNTFR, KIF2B
11	ataxia	47.0	VWF, RDPA, BTD, SETX, SERPINE1, VIM
12	myopathy	46.2	PIK3C2A, NCAM1, VPS13A, BTD, SELE, VIM
13	axonal neuropathy	45.6	NCAM1, KIF1A, KIF1B, KIF5A, VPS13A, SETX
14	adenocarcinoma	45.3	PIK3C2A, NCAM1, CNR1, VWF, PC, GCG
15	charcot-marie-tooth neuropathy	44.8	KIF1B, RBBP4, LMNA, RAB7A, LITAF, CMT1A
16	obesity	44.7	PIK3C2A, PDE3B, REN, RETN, CNR1, CNTF
17	charcot-marie-tooth disease	44.5	ZNF673, CNTF, KIF2B, KIF1B, LMNA, RAB7A
18	tooth disease	44.1	ZNF673, CNTF, KIF2B, KIF1B, LMNA, RAB7A
19	autonomic neuropathy	43.4	REN, KIF1A, GCG, RAB7A, MLN, MLNR
20	ischemia	43.3	PIK3C2A, NCAM1, REN, RETN, CNR1, CNTF
21	thyroiditis	43.0	PICALM, PIK3C2A, NCAM1, REN, RETN, VWF
22	hearing loss	42.5	BTD, SERPINE1, BDNF, MT-ND5, MT-CO1, MTHFR
23	polyneuropathy	42.4	CNTF, KIF1B, VEGFA, LIF, CLDN5, PARP1
24	nephropathy	42.2	REN, RETN, VWF, GCG, SELE, SERPINF1
25	anemia	41.2	NCAM1, REN, VWF, SELE, SERPING1, NAGLU
26	blindness	40.7	PIK3C2A, REN, CNR1, CNTF, VWF, GCG
27	cataract	40.7	SERPINF1, VIM, NAGLU, VEGFA, LMNA, MYOC
28	dementia	40.4	PIK3C2A, NCAM1, VWF, SERPINF1, SERPINE1, VIP
29	cholesterol	40.4	PIK3C2A, PDE3B, REN, RETN, CNR1, VWF
30	ovarian cancer	40.3	ZNF673, NCAM1, VWF, SELE, SERPINF1, SERPINE1
31	hypoxia	40.3	PIK3C2A, REN, VWF, PC, SELE, SERPINF1
32	diabetic neuropathy	40.2	CNTF, MPZ, INS, AKR1B1, TRPV1, NTF3
33	neurodegeneration	40.2	CNR1, CNTF, VPS13A, SERPINF1, VIP, BSCL2
34	arthritis	39.9	SH2D2A, RETN, CNR1, CNTF, KIF5A, VWF
35	fibrosis	39.8	REN, RETN, CNR1, VWF, BTD, SELE
36	spasticity	39.3	REEP1, CNR1, KIF1A, KIF5A, BTD, BSCL2
37	amyotrophic lateral sclerosis	38.8	CNR1, CNTF, CNTFR, SELE, SETX, SERPINE1
38	lateral sclerosis	38.8	CNR1, CNTF, CNTFR, SELE, SETX, SERPINE1
39	leber hereditary optic neuropathy	38.7	MYOC, MT-ND5, MT-CO1, MT-ND4, MT-CO3, MT-CYB
40	peritonitis	38.4	PIK3C2A, PDE3B, REN, CNTF, VWF, SELE
41	glaucoma	38.2	REN, CNR1, CNTF, VWF, SELE, SERPINF1
42	rheumatoid arthritis	38.2	SH2D2A, RETN, CNR1, CNTF, KIF5A, VWF
43	hereditary neuropathies	38.0	LMNA, RAG1, MTMR2, MPZ, MAG, GJB1
44	insulin resistance	38.0	PDE3B, REN, RETN, CNR1, CNTF, VWF
45	myeloma	37.6	NCAM1, CNTF, CNTFR, VWF, NAGLU, VEGFA
46	distal hereditary motor neuropathy	37.6	REEP1, SETX, BSCL2, CLIP1, CLIP2, ATP7A
47	seizures	37.3	PIK3C2A, CNR1, CNTF, BTD, VIM, VIP
48	hereditary neuropathy with liability to pressure palsies	37.2	PABPN1, MPZ, GJB1, COX10, SH3TC2, PMP22
49	motor neuron disease	37.0	CNTF, BTD, SETX, BSCL2, VEGFA, LIF
50	ischemic optic neuropathy	37.0	PION, VEGFA, BEX1, BEX2, MTHFR, MT-ND1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to neuropathy:

²²

FMA organs/tissues related to neuropathy:

¹¹

MGI Mouse Phenotypes related to neuropathy:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	INF	CNR1, KIF1B, NAB2, NAGLU, NAB1, VEGFA
2	behavior/neurological phenotype	MP:0005386	INF	NCAM1, REN, CNR1, CNTF, CNTFR, CNTNAP1
3	cellular phenotype	MP:0005384	INF	PICALM, SH2D2A, NCAM1, CNR1, CNTF, KIF5A
4	nervous system phenotype	MP:0003631	INF	REN, CNR1, CNTF, CNTFR, CNTNAP1, KIF1B
5	growth/size phenotype	MP:0005378	INF	PICALM, PIK3C2A, PDE3B, REN, CNR1, CNTNAP1
6	limbs/digits/tail phenotype	MP:0005371	INF	VEGFA, LMNA, UTRN, LEP, CHKB, MTMR2
7	embryogenesis phenotype	MP:0005380	INF	PICALM, VIM, LIG3, PARP1, SCO2, ATP1A2
8	muscle phenotype	MP:0005369	INF	REN, CNTF, CNTNAP1, KIF1B, BTD, VIM
9	digestive/alimentary phenotype	MP:0005381	INF	VWF, GCG, SERPINF1, BSCL2, VEGFA, LMNA
10	reproductive system phenotype	MP:0005389	INF	REN, CNTNAP1, SERPINF1, VIP, NAB2, NAB1
11	no phenotypic analysis	MP:0003012	INF	CNR1, BSCL2, VEGFA, MYOC, MYOT, PARP1
12	renal/urinary system phenotype	MP:0005367	INF	REN, BTD, BSCL2, NAGLU, LMNA, RAG1
13	normal phenotype	MP:0002873	17.0	REN, SELE, SERPING1, VIP, NAB2, NAB1
14	endocrine/exocrine gland phenotype	MP:0005379	12.9	PARL, XDH, ATXN2, ATCAY, CD40LG, GSC
15	adipose tissue phenotype	MP:0005375	12.6	PIK3C2A, PDE3B, RETN, CNR1, SERPINE1, BSCL2
16	integument phenotype	MP:0010771	INF	PDE3B, CNR1, KIF1A, KIF1B, BTD, BSCL2
17	immune system phenotype	MP:0005387	INF	PICALM, SH2D2A, REN, CNTF, VWF, VIM
18	respiratory system phenotype	MP:0005388	INF	KIF1B, KIF5A, NAB2, NAB1, RAG1, UTRN
19	cardiovascular system phenotype	MP:0005385	INF	REN, VWF, SELE, SEPT5, SERPINF1, SERPINE1
20	hematopoietic system phenotype	MP:0005397	INF	PICALM, SH2D2A, CNTF, VPS13A, SEPT5, BSCL2
21	hearing/vestibular/ear phenotype	MP:0005377	INF	NAGLU, LMNA, RAG1, PARP1, BDNF, SCARB2
22	mortality/aging	MP:0010768	INF	PICALM, PIK3C2A, NCAM1, REN, CNR1, CNTFR
23	homeostasis/metabolism phenotype	MP:0005376	INF	PICALM, PIK3C2A, PDE3B, REN, RETN, CNR1
24	tumorigenesis	MP:0002006	INF	SERPINE1, RAG1, LEP, B2M, ITGB3, ITIH4
25	vision/eye phenotype	MP:0005391	INF	NCAM1, CNTNAP1, BTD, SELE, SERPINF1, VIM
26	other phenotype	MP:0005395	INF	CNR1, CD40LG, ITGB3, IL2, APOE, HSPG2
27	craniofacial phenotype	MP:0005382	INF	NAGLU, LIG3, BDNF, FOXE1, ASPA, FLVCR1
28	liver/biliary system phenotype	MP:0005370	INF	PICALM, RETN, BSCL2, VEGFA, RAG1, UTRN
29	pigmentation phenotype	MP:0001186	INF	PDE3B, BTD, SERPINF1, NAGLU, LMNA, RAG1

Articles related to neuropathy:

(show top 50)    (show all 1296)

id	Title	Authors	Year	Affiliating Genes
1	Sensory ataxic neuropathy dysarthria and ophthalmopar esis (SANDO) in a sibling pair with a homozygous p.A467T POLG mutation. (19813183)	McHugh J.C.... Connolly S.	2010	POLG
2	Advances and perspectives in treatment for refractor y neuropathies with special reference to immune-mediated neuropathies and Crow- Fukase syndrome (20411803)	Kuwabara S.	2010	VEGFA
3	Anti-ganglioside complex IgM antibodies in multifocal motor neuropathy and chronic immune-mediated neuropathies. (20006388)	Nobile-Orazio E.... Briani C.	2010	CD40LG
4	Screening mutations of OTOF gene in Chinese patients with auditory neuropathy, including a familial case of temperature-sensitive au ditory neuropathy. (20504331)	Wang D.Y.... Wang Q.J.	2010	OTOF
5	Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1. (19592619)	Vincent A.M.... Feldman E.L.	2009	OLR1
6	Genome-wide screen identifies drug-induced regulation of the gene giant axonal neuropathy (Gan) in a mouse model of antiretroviral-i nduced painful peripheral neuropathy. (19398414)	Dorsey S.G.... Dionne R.A.	2009	GAN
7	Axonal neuropathy due to myelin protein zero mutation misdiagnosed as amyloid neuropathy. (18563718)	Briani C.... Fabrizi G.	2008	MPZ
8	Hereditary neuropathy with liability to pressure palsies in a Turkish patient (HNPP): a rare cause of entrapment neuropathies in young adults. (18382985)	Celik Y.... Utku U.	2008	PMP22
9	Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. (17582772)	Yilmaz Z.... Anand P.	2007	NGF, TRPV1
10	Mitochondrial GTPase mitofusin 2 mutations in Korean patients with Charcot-Marie-Tooth neuropathy type 2. (17309650)	Cho H.J.... Ki C.S.	2007	MFN2
11	Vasculitic neuropathy in a patient with hereditary C1 inhibitor deficiency. (17502473)	Yakushiji Y.... Kuroda Y.	2007	SERPING1
12	Modeling the tertiary structure of the patatin domain of neuropathy target esterase. (17216363)	Wijeyesakere S.J.... Stuckey J.A.	2007	PNPLA6
13	Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit. (17084535)	Xiao W.... Luo Z.D.	2007	CACNA2D1
14	Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (cmtx5). (17701900)	Kim H.-J.... Kim J.-W.	2007	PRPS1, PRPS1L1
15	Inherited focal, episodic neuropathies: hereditary neuropathy with liability to pressure palsies and hereditary neuralgic amyotrophy. (16775374)	Chance P.F.	2006	SEPT9
16	Effects of basic fibroblast growth factor on experimental diabetic neuropathy in rats. (16644707)	Nakae M.... Nakamura J.	2006	NUDT6
17	Autosomal recessive spastic paraplegia (SPG30) with mild ataxia and sensory neuropathy maps to chromosome 2q37.3. (16434418)	Klebe S.... Stevanin G.	2006	KIF1A
18	Molecular genetics of hereditary sensory neuropathies. (16775373)	Auer-Grumbach M.... Pieber T.R.	2006	NGFR
19	Clinical, electrophysiological and molecular genetic studies in a family with X-linked dominant Charcot-Marie-Tooth neuropathy presenting a novel mutation in GJB1 Promoter and a rare polymorphism in LITAF/SIMPLE. (16373087)	Beauvais K.... Latour P.	2006	EGR2, GJB1, LITAF
20	Statin induced neuropathy: myth or reality? (17151526)	Formaglio M.... Vial C.	2006	HMGCR
21	Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia. (16950614)	Sissung T.M.... Mielke S.	2006	ABCB1
22	The G526R glycyl-tRNA synthetase gene mutation in distal hereditary motor neuropathy type V. (16769947)	Dubourg O.... Leguern E.	2006	GARS
23	Association of HLA DQB1 0602 in sarcoidosis patients with small fiber neuropathy. (16053028)	Voorter C.E.... van den Berg-Loonen E.M.	2005	HLA-A, HLA-DQB1, HLA-DRB1
24	Vascular calcification and osteolysis in diabetic neuropathy-is RANK-L the missing link? (15322748)	Jeffcoate W.	2004	TNFRSF11B, TNFSF11
25	Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy. (15122253)	Irobi J.... Timmerman V.	2004	HSPB1, PRKAB1, HSPB8
26	Loss-of-function phenotype of hereditary neuropathy with liability to pressure palsies. (14755484)	Li J.... Shy M.E.	2004	PMP22
27	Mutations in a gene encoding a novel SH3/TPR domain protein cause autosomal recessive Charcot-Marie-Tooth type 4C neuropathy. (14574644)	Senderek J.... Zerres K.	2003	CSNK1A1, SH3TC2
28	Hypoglossal neuropathy in hereditary neuropathy with liability to pressure palsy. (14581692)	Winter W.C.... Juel V.C.	2003	PMP22
29	Autosomal dominant sensory/motor neuropathy with Ataxia (SMNA): Linkage to chromosome 7q22-q32. (11992570)	Brkanac Z.... Raskind W.H.	2002	SCA18
30	Mild recurrent neuropathy in CMT1B with a novel nonsense mutation in the extracellular domain of the MPZ gene. (11160475)	Lagueny A.... Vandenberghe A.	2001	MPZ
31	Subacute neuropathy, multiple cancers, and Gougerot-Sjogren syndrome: contribution of anti-Hu antibody (11283468)	Auf G.... Delattre J.Y.	2001	ELAVL4
32	Hereditary neuropathy with liability to pressure palsies mimicking multifocal compression neuropathy. (11466642)	Lane J.E.... Adkison L.	2001	PMP22
33	Phe 84 deletion of the PMP22 gene associated with hereditary motor and sensory neuropathy HMSN III with multiple cranial neuropathy: clinical, neurophysiological and magnetic resonance imaging findings. (11355152)	Yener G.G.... GenAs A.	2001	PMP22
34	A clone contig of 12q24.3 encompassing the distal hereditary motor neuropathy type II gene. (10777663)	Irobi J.... Beuten J.	2000	HSPB8
35	The genetics of type 1 Charcot-Marie-Tooth disease, the hereditary focal neuropathies and the hereditary distal motor neuropathies (10743001)	Sevilla T.	2000	EGR2, PMP22
36	Motor neuropathy in porphobilinogen deaminase-deficient mice imitates the peripheral neuropathy of human acute porphyria. (10207164)	Lindberg R.L.... Meyer U.A.	1999	HMBS
37	Risks for sensorimotor peripheral neuropathy and autonomic neuropathy in non-insulin-dependent diabetes mellitus (NIDDM). (9427226)	COHEN J.A.... Schrier R.W.	1998	INS
38	Delayed neuropathy and inhibition of soluble neuropathy target esterase following the administration of organophosphorus compounds to hens. (9823777)	Tian Y.... Yamauchi T.	1998	ACHE, PNPLA6
39	Gene dosage effects in hereditary peripheral neuropathy. Expression of peripheral myelin protein 22 in Charcot-Marie-Tooth disease type 1A and hereditary neuropathy with liability to pressure palsies nerve biopsies. (9409359)	Gabriel J.M.... Steck A.J.	1997	PMP22
40	Tomaculous neuropathy in Charcot-Marie-Tooth disease with myelin protein zero gene mutation. (9455987)	Tachi N.... Sasaki K.	1997	MPZ
41	Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: multicenter study. Diabetic Neuropathy Study Group in Japan. (8807467)	Hotta N.... Goto Y.	1996	AKR1B1
42	Hereditary neuropathy with liability to pressure palsies: distinguishing clinical and electrophysiological features among patients with multiple entrapment neuropathy. (8856651)	Hirota N.... Kimura J.	1996	PMP22
43	Clinical trials of diabetic neuropathy: past, present , and future. (7589838)	Pfeifer M.A.... Schumer M.P.	1995	AKR1B1
44	Reproducibility of parameters for assessment of diabe tic neuropathy. The French Group for Research and Study of Diabetic Neuropathy. (8306589)	Valensi P.... Gagant S.	1993	AKR1B1
45	The R-(+)isomer of O-n-hexyl S-methyl phosphorothioamidate causes delayed neuropathy in hens after generation of a form of inhibited neuropathy target esterase (NTE) which can be reactivated ex vivo. (8344001)	Johnson M.K.... Safi J.M.	1993	PNPLA6
46	Charcot-Marie-Tooth Neuropathy T ype 2D/Distal Spinal Muscular Atrophy V (20301420)	Goldfarb L.G.... Sivakumar K.	1993	GARS, BSCL2
47	Cytochrome c oxidase mutations in Leber hereditary optic neuropathy. (8240356)	Johns D.R.... Neufeld M.J.	1993	MT-CO3
48	Alternative, simultaneous complex I mitochondrial DNA mutations in Leber's hereditary optic neuropathy. (1900003)	Johns D.R.... Berman J.	1991	MT-ND5, MT-ND2, MT-ND1
49	Diabetes mellitus and its complications in Japan. Polyol pathway and diabetic neuropathy: selective preventive effect of aldose reductase inhibitor on the experimental diabetic neuropathy (1837043)	Kamijo M.... Yagihashi S.	1991	AKR1B1
50	Polyol pathway and diabetic neuropathy: selective preventive effects of an aldose reductase inhibitor in experimental diabetic neuropathy. (1798234)	Kamijo M.... Yagihashi S.	1991	AKR1B1

Genes related to neuropathy according to GeneCards:

(show top 50)    (show all 626)

id	Symbol	Description	Score	GeneCards Section Context
1	GJB1	gap junction protein, beta 1, 32kDa	11.1	Publications, Aliases & Descriptions, Orthologs, Summaries
2	SPTLC1	serine palmitoyltransferase, long chain base subunit 1	11.1	Publications, Aliases & Descriptions, Summaries
3	GDAP1	ganglioside induced differentiation associated protein 1	11.1	Publications, Aliases & Descriptions, Summaries
4	GAN	gigaxonin	11.1	Publications, Aliases & Descriptions, Orthologs, Summaries
5	SLC12A6	solute carrier family 12 (potassium/chloride transporters), member 6	11.1	Publications, Aliases & Descriptions, Summaries
6	WNK1	WNK lysine deficient protein kinase 1	11.1	Publications, Aliases & Descriptions, Summaries
7	PMP22	peripheral myelin protein 22	11.1	Publications, Summaries
8	MPZ	myelin protein zero	11.1	Publications, Aliases & Descriptions
9	DIAPH3	diaphanous homolog 3 (Drosophila)	11.1	Publications, Aliases & Descriptions, Summaries
10	GARS	glycyl-tRNA synthetase	11.1	Publications, Aliases & Descriptions
11	NGF	nerve growth factor (beta polypeptide)	11.1	Publications, Summaries
12	CMT1A	Charcot-Marie-Tooth neuropathy 1A (greatly reduced nerve conduction velocity, hereditary motor sensory neuropathy Ia)	11.1	Aliases & Descriptions, Publications
13	NEFL	neurofilament, light polypeptide	11.0	Publications, Summaries
14	MFN2	mitofusin 2	11.0	Publications, Summaries
15	MTMR2	myotubularin related protein 2	11.0	Publications, Summaries
16	PRX	periaxin	11.0	Publications, Summaries
17	TRPV4	transient receptor potential cation channel, subfamily V, member 4	11.0	Publications, Summaries
18	SPTLC2	serine palmitoyltransferase, long chain base subunit 2	11.0	Publications, Summaries
19	RAB7A	RAB7A, member RAS oncogene family	11.0	Publications, Summaries
20	TDP1	tyrosyl-DNA phosphodiesterase 1	11.0	Publications, Summaries
21	HSPB1	heat shock 27kDa protein 1	11.0	Publications, Summaries
22	POLG	polymerase (DNA directed), gamma	11.0	Publications, Summaries
23	FAM134B	family with sequence similarity 134, member B	11.0	Publications, Summaries
24	IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	11.0	Publications, Aliases & Descriptions
25	SBF2	SET binding factor 2	11.0	Publications, Aliases & Descriptions
26	NMSR	Neuropathy, hereditary motor and sensory, Russe type	11.0	Publications, Aliases & Descriptions
27	CMTX2	Charcot-Marie-Tooth neuropathy, X-linked 2 (recessive)	11.0	Aliases & Descriptions
28	CMTX3	Charcot-Marie-Tooth neuropathy, X-linked 3 (dominant)	11.0	Aliases & Descriptions, Publications
29	GJB3	gap junction protein, beta 3, 31kDa	11.0	Publications, Summaries
30	KIF1A	kinesin family member 1A	11.0	Publications, Summaries
31	OPA1	optic atrophy 1 (autosomal dominant)	11.0	Publications, Summaries
32	COX10	COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)	11.0	Summaries
33	HMNJ	Distal hereditary motor neuropathy, Jerash type	11.0	Aliases & Descriptions
34	CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	11.0	Publications, Summaries
35	GJB6	gap junction protein, beta 6, 30kDa	11.0	Publications, Summaries
36	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	11.0	Summaries
37	GJB2	gap junction protein, beta 2, 26kDa	11.0	Publications, Summaries
38	HMSNO	Neuropathy, hereditary motor and sensory, Okinawa type	11.0	Aliases & Descriptions, Publications
39	SPOAN	spastic paraplegia, optic atrophy, and neuropathy	11.0	Aliases & Descriptions, Publications
40	AUNX1	auditory neuropathy, X-linked recessive 1	11.0	Publications, Aliases & Descriptions
41	GJE1	gap junction protein, epsilon 1, 23kDa	11.0	Summaries
42	GJA10	gap junction protein, alpha 10, 62kDa	11.0	Summaries
43	GJD3	gap junction protein, delta 3, 31.9kDa	11.0	Summaries
44	GJA9	gap junction protein, alpha 9, 59kDa	11.0	Summaries
45	GJB5	gap junction protein, beta 5, 31.1kDa	11.0	Summaries
46	GJC3	gap junction protein, gamma 3, 30.2kDa	11.0	Summaries
47	GJD4	gap junction protein, delta 4, 40.1kDa	11.0	Summaries
48	GJB4	gap junction protein, beta 4, 30.3kDa	11.0	Summaries
49	GJC2	gap junction protein, gamma 2, 47kDa	11.0	Summaries
50	GJD2	gap junction protein, delta 2, 36kDa	11.0	Summaries

Pathways related to neuropathy according to GeneDecks:

(show top 50)    (show all 103)

id	Pathway	Score	Top Affiliating Genes
1	Metabolic pathways20	18.1	PIK3C2A, PC, BTD, NAGLU, UROD, SDHA
2	Oxidative phosphorylation20	13.4	SDHA, MT-ND5, MT-ND4L, MT-ND3, MT-CO1, MT-ND4
3	Parkinsons disease20	13.3	SEPT5, SDHA, MT-ND5, MT-ND4L, MT-ND3, MT-CO1
4	Huntingtons disease20	13.2	BDNF, SDHA, UCP1, MT-CO1, MT-ATP6, MT-CO3
5	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.38	13.1	MT-ND5, MT-ND4L, MT-ND3, MT-CO1, MT-ND4, MT-ATP6
6	Neuroscience3	12.9	NCAM1, ATXN1, GSTP1, GRIA3, MAG, TUBA1B
7	Cell adhesion Gap junctions10	12.7	GJA3, GJA4, GJA5, GJA8, GJB1, GJB2
8	Signaling in Gap Junctions36	12.6	GRM2, GRM4, MAPK1, HTR2A, GNB2, GJA1
9	Cell adhesion_Gap junctions41	12.2	GJA1, GJA3, GJA4, GJA5, GJA8, GJB1
10	Cytokine-cytokine receptor interaction20	12.0	CNTF, CNTFR, VEGFA, LIF, LEP, CD40LG
11	Doxorubicin Pathway, Pharmacokinetics34	11.8	XDH, GPX1, CAT, AKR1A1, NQO1, NOS2
12	Mitochondrial Apoptosis36	11.7	BDNF, FGFR1, FGFR2, IL2, IL2RA, IL3
13	Cellular Apoptosis Pathway36	11.7	BDNF, FGFR1, FGFR2, IL2, IL2RA, IL3
14	PPAR Pathway36	11.6	ITGB3, FGFR1, FGFR2, IL2, IL2RA, IL3
15	Apoptotic Pathways in Synovial Fibroblasts36	11.5	BDNF, FGFR1, FGFR2, IL2, IL2RA, IL3
16	STAT3 Pathway36	11.5	LIF, CD4, CD80, IL10, IL12B, IL1A
17	PEDF Induced Signaling36	11.4	SERPINF1, LIF, BDNF, CD80, IL10, IL12B
18	Cytoskeleton remodeling Neurofilaments10	11.4	KIF5A, VIM, TUBA1A, TUBA1B, TUBA1C, TUBB
19	RAR-Gamma-RXR-Alpha Degradation36	11.4	LIF, CD80, IL2, IL3, MAPK14, PSMD9
20	p38 Signaling36	11.3	LIF, BDNF, AXL, CD4, CD80, FGFR1
21	Tec Kinases Signaling36	11.2	BDNF, CD4, CD80, ITGB3, FGFR1, FGFR2
22	Malaria20	11.2	SELE, CD36, CD40LG, IL10, IL1B, IL6
23	Type I diabetes mellitus20	11.1	CD80, INS, IL12B, IL1A, IL1B, IL2
24	Akt Signaling36	11.1	PDE3B, LIF, AXL, CD4, CD80, FGFR1
25	Cytokine Network36	11.1	IL10, IL12B, IL1A, IL1B, IL2, IL3
26	Cytoskeleton remodeling_Neurofilaments41	11.0	KIF5A, VIM, TUBA1A, TUBA1B, TUBA1C, TUBB
27	PAK Pathway36	11.0	LIF, CD80, FGFR1, FGFR2, IL10, IL12B
28	all-trans-Retinoic Acid Signaling in Brain36	10.7	LIF, CD80, IL10, IL12B, IL1A, IL1B
29	ERK Signaling36	10.7	AXL, CD80, FGFR2, IL10, IL12B, IL1A
30	Allograft rejection20	10.6	CD40LG, CD80, IL10, IL12B, IL2, IL4
31	MIF Mediated Glucocorticoid Regulation36	10.6	LIF, CD80, IL10, IL12B, IL1A, IL1B
32	Angiogenesis3	10.5	REN, ITGB3, MMP2, MMP7, MMP9, FGFR1
33	Pancreatic Adenocarcinoma36	9.6	BDNF, AXL, MMP2, MMP7, MMP9, FGFR1
34	Influenza A20	INF	PABPN1, , IVNS1ABP, IL12B, IL1A, IL1B
35	Rheumatoid arthritis20	INF	VEGFA, , CD80, IL1A, IL1B, IL6
36	Leishmaniasis20	INF	, IL10, IL12B, IL1A, IL1B, IL4
37	Antioxidant Action of Vitamin-C36	INF	LIF, BDNF, , CD4, CD80, FGFR1
38	Molecular Mechanisms of Cancer36	INF	LIF, BDNF, , CD4, CD80, FGFR1
39	Selected targets of CREB110	INF	REN, GCG, LIF, CHAT, INS, CCR5
40	MAPK Family Pathway36	INF	BDNF, , CD4, CD80, FGFR1, FGFR2
41	Chagas disease (American trypanosomiasis)20	INF	SERPINE1, , IL10, IL12B, IL1B, IL6
42	Rho Family GTPases36	INF	VIM, LIF, BDNF, CIT, AXL, MSN
43	Endothelin-1 Signaling Pathway36	INF	AXL, CD80, FGFR2, IL10, IL12B, IL1A
44	MIF Regulation of Innate Immune Cells36	INF	LIF, , CD80, IL10, IL12B, IL1A
45	Immune response IL-1 signaling pathway10	INF	SERPINE1, , IL1A, IL1B, IL6, IL8
46	NFAT in Immune Response36	INF	BDNF, AXL, , CD79A, CD4, CD80
47	Immune response_IL-1 signaling pathway41	INF	SERPINE1, , IL1A, IL1B, IL6, IL8
48	JAK-STAT Pathway36	INF	BDNF, AXL, , CD4, CD80, FGFR1
49	Renin-Angiotensin Pathway36	INF	REN, BDNF, , FGFR1, FGFR2, IL2
50	TGF-Beta Pathway36	INF	BDNF, , CD4, CD80, FGFR1, FGFR2

Compounds related to neuropathy according to GeneDecks:

(show top 50)    (show all 531)

id	Compound	Score	Top Affiliating Genes
1	pioglitazone32 9 9	INF	RETN, GCG, VEGFA, LEP, , MMP2
2	rosiglitazone32 9 18 9	INF	RETN, SELE, SERPINE1, LMNA, LEP, UCP1
3	genistein32 9 18 9	INF	CNTF, GCG, SELE, SERPINE1, VIM, VEGFA
4	estrogen32	14.7	ZNF673, RETN, VWF, GCG, SERPINE1, VIP
5	ethanol32 34 9 18 9	18.1	NCAM1, BDNF, UROD, BCHE, CHKA, CHAT
6	valine32	13.9	VIM, VIP, BDNF, UCP2, MT-ND5, MT-ND4
7	malondialdehyde32	13.2	PIK3C2A, NAGLU, CHKA, CHAT, CHKB, XDH
8	cocaine32 9 9	14.8	PIK3C2A, CNR1, CNTF, GCG, SELE, VIM
9	streptozotocin32	12.5	GCG, SERPINF1, VIM, NAGLU, BDNF, CHGA
10	betacarotene32	12.5	VWF, LIF, LEP, CHKA, MTHFR, CD79A
11	levodopa32 9 9	14.4	CNR1, BDNF, CHGA, CHKB, AKR1A1, AKR1B1
12	ganglioside32	12.4	NCAM1, CNTF, VIM, MPZ, CD4, ITIH4
13	catecholamine32	12.3	PIK3C2A, REN, CNTF, VIM, CHAT, CHGA
14	polysaccharide32	12.1	NCAM1, SELE, LIF, SCARB2, CHKB, B2M
15	manganese superoxide32	11.9	UCP1, UCP2, GSR, GSTM1, GSTP1, GSTT1
16	prednisolone32 9 9	13.9	PIK3C2A, VWF, VIP, CHKB, MPO, CD79A
17	glycerol32 9 18 9	14.9	PIK3C2A, VWF, PC, GCG, LEP, CHKB
18	prostaglandin32	11.8	REN, CNTF, VIM, VIP, LIF, UCP2
19	l-nmma32	11.6	VIP, XDH, IL1RN, CCK, CAT, NOS2
20	agar32	11.6	VIM, CD40LG, FGFR1, FGFR2, IGF1R, GLA
21	nadph32 18	12.6	PC, CHAT, UCP2, CYP2D6, CYBA, OLR1
22	morphine32 9 9	13.5	CNR1, VIP, ITIH4, IL1RN, CCR5, CCK
23	thalidomide32 42 9 9	14.4	VEGFA, B2M, CD36, CD40LG, FGFR2, IL10
24	carbachol32 9 9	13.3	GCG, CCK, HSPG2, PTH, TAC1, OPRD1
25	n acetylcysteine32	11.2	VWF, SELE, NAGLU, BDNF, CD79A, MMP2
26	cyclophosphamide32 34 9 9	13.8	APOH, F8, TAC1
27	corticosterone32 18	11.8	CNR1, GCG, VIP, LIF, BDNF, MPO
28	polymyxin b32	10.4	SELE, SERPINE1, IL10, IL1A, IL1B, IL1RN
29	succinate32	INF	SELE, SDHA, CHKB, UCP2, MT-CO1, MT-ND4
30	herbimycin a32 42	INF	SELE, , CD36, CD4, CD40LG, MMP2
31	tamoxifen32 34 9 9	INF	SELE, VIM, VEGFA, BDNF, CKB, LEP
32	methionine32	INF	CNTF, VWF, SERPINF1, VIM, LIF, BDNF
33	retinoic acid32 42 18	INF	NCAM1, CNTF, CNTFR, VWF, SERPINF1, SERPINE1
34	mg 13232 42	INF	PARP1, , IL1A, IL1B, IL8, FAS
35	lipid32	INF	PIK3C2A, NCAM1, PDE3B, RETN, CNR1, CNTF
36	indomethacin32 9 9	INF	REN, CNR1, GCG, VIM, VIP, BDNF
37	pd 98,05932	INF	CNTF, GCG, SERPINE1, LIF, PARP1, BDNF
38	aspartate32	INF	PIK3C2A, RETN, CNR1, PC, VIM, VIP
39	sodium32 18	INF	PIK3C2A, NCAM1, REN, RETN, CNTNAP1, NAGLU
40	copper32 18	INF	NAGLU, RAB7A, LIF, SCO2, MT-CO1, MT-CYB
41	fenofibrate32 9 9	INF	PIK3C2A, RETN, SELE, SERPINE1, LEP, UCP2
42	thymidine32 18	INF	PDE3B, CNTF, VIP, NAGLU, LIF, BDNF
43	proline32	INF	VIM, BDNF, MT-ND3, MT-ATP6, MT-ND1, AVP
44	wortmannin32 42	INF	PIK3C2A, PDE3B, CNTF, GCG, VIM, LIF
45	butyrate32	INF	GCG, VIM, BCHE, LEP, CHAT, B2M
46	quercetin32 42 9 18 9	INF	PIK3C2A, SELE, PARP1, XDH, , GSR
47	carbon32	INF	CNR1, VWF, PC, BCHE, UCP1, MTHFR
48	threonine32	INF	MT-ND5, MT-ND3, MT-ND4, MT-CYB, MT-ND1, MT-ND2
49	azathioprine32 34 9 9	INF	VIM, LIF, CHKB, MTHFR, XDH, CD79A
50	progesterone32 42 9 18 9	INF	NCAM1, CNTF, LIF, CKB, CHKA, CHGA

Cellular components related to neuropathy according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	INF	REN, CNTF, GCG, BTD, SELE, SERPINF1
2	mitochondrion	GO:005739	INF	ACADS, ELN, HK1, TOMM40, DGUOK, PSAP
3	plasma membrane	GO:005886	INF	EGFR, , NDRG1, SH3TC2, SKAP2, PDYN
4	integral to plasma membrane	GO:005887	INF	RHBDL1, , , ABCB4, ABCC2, ACVRL1
5	connexon complex	GO:005922	13.7	GJA1, GJB6, GJB7, GJC1, GJC2, GJC3
6	mitochondrial inner membrane	GO:005743	11.8	NDUFAF6, NDUFB11, NDUFS1, NDUFS2, NDUFS4, NDUFS7
7	secretory granule	GO:030141	11.6	HSPD1, CYBA, PLAT, DBH, POMC, GARS
8	neuronal cell body	GO:043025	11.3	DBH, DFNB59, TAC1, DPYSL5, TGFB1, PRPH
9	external side of plasma membrane	GO:009897	10.9	ICOS, ICOSLG, HLA-DRB1, TRPM8, TNF, ACE
10	cytoplasm	GO:005737	INF	NDRG4, NDRG3, NDRG2, NDRG1, NFKB1, NF1
11	axon	GO:030424	INF	NF1, DST, TGFB1, TAC1, SLC6A1, NEFH
12	cytosol	GO:005829	INF	HSPB1, GJA1, HMOX1, HMBS, AIF1, AIFM1
13	perinuclear region of cytoplasm	GO:048471	INF	HFE, ACHE, EGFR, NDRG2, NDRG1, NOS2
14	extracellular region	GO:005576	INF	PON1, GAL, GAST, GDNF, GABBR1, EPO
15	membrane raft	GO:045121	INF	EGFR, , HK1, TLR4, PRNP, OPRD1

Biological processes related to neuropathy according to GeneDecks:

(show all 30)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:008284	INF	NTRK2, HMX2, CAPNS1, F2, HTR2A, IGF1
2	angiogenesis	GO:001525	INF	TEK, , PNPLA6, NOS3, ACVRL1, HIF1A
3	negative regulation of neuron apoptotic process	GO:043524	INF	NGF, HIF1A, AGT, SOD1, SOD2, WFS1
4	cell-cell signaling	GO:007267	13.3	NTF3, PTH, TEK, GJC2, GJB2, GJB1
5	synaptic transmission	GO:007268	13.2	PRKCB, DBH, TAC1, HCN3, ACHE, PDYN
6	transport	GO:006810	13.0	ABCB4, ABCB1, DYNC1H1, TRPV1, GJC1, ABCC2
7	blood coagulation	GO:007596	12.6	NOS3, NOS2, PLAT, OLR1, TEK, TP53
8	platelet activation	GO:030168	11.8	F8, F5, F2, ALB, TGFB1, PSAP
9	myelination	GO:042552	11.8	AFG3L2, DHH, TGFB1, HEXA, EGR2, NTF3
10	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	11.7	CCK, IGF1, TP53, AGT, TLR4, HGF
11	respiratory electron transport chain	GO:022904	11.7	NDUFB11, NDUFS1, NDUFS2, NDUFS4, NDUFS7, NDUFV1
12	anti-apoptosis	GO:006916	11.6	RPS27A, NOS3, NRG1, TEK, TNF, NGF
13	response to hypoxia	GO:001666	11.5	HIF1A, EDN1, PDE5A, NF1, NOS3, TLR4
14	cell communication	GO:007154	11.5	GJD4, GJE1, NRG1, SNX25, NF1, SLC8A3
15	positive regulation of MAPK cascade	GO:043410	11.4	IL6, IGF1, DUSP19, NTRK2, AGT, GRM4
16	blood vessel remodeling	GO:001974	11.2	AGT, ELN, ACVRL1, NOS3, IGF1, ATP7A
17	response to glucocorticoid stimulus	GO:051384	11.1	TNF, PTGS2, PLAT, NGF, ABCB4, ACADS
18	platelet degranulation	GO:002576	11.0	F5, ALB, TGFB1, PSAP, SOD1, KNG1
19	inflammatory response	GO:006954	10.9	AGER, NFKB1, NGF, CRP, OLR1, CYBA
20	immune response	GO:006955	10.3	TNFSF11, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A, ICOS
21	positive regulation of nitric oxide biosynthetic process	GO:045429	10.2	TLR4, EGFR, EDN1, PTGS2, TNF, AIF1
22	mitochondrial respiratory chain complex I assembly	GO:032981	9.8	NUBPL, NDUFS7, NDUFS4, NDUFAF6, NDUFAF5, NDUFAF4
23	regulation of blood pressure	GO:008217	INF	ACE, ACVRL1, TAC1, SOD1, SOD2, POMC
24	aging	GO:007568	INF	CALCA, HMGCR, PTGS1, NOS3, AGT, TGFB1
25	response to drug	GO:042493	INF	GAD2, EDN1, NGF, NOS3, PTGS2, TNFRSF11B
26	negative regulation of apoptotic process	GO:043066	INF	EGFR, PLK2, TEK, TNF, TP53, AIF1
27	cellular response to lipopolysaccharide	GO:071222	INF	CCR5, IFNG, TNFRSF1B, NOS2, , TLR4
28	small molecule metabolic process	GO:044281	INF	HADHB, HADHA, ADH1B, ADCY1, AAAS, LYPLA1
29	cell death	GO:008219	INF	C19orf12, GJC2, HSPB8, HSPB3, HSPB1, HTR2A
30	nervous system development	GO:007399	INF	DPYSL5, ELAVL3, ACHE, , NDRG2, PDE5A

Molecular functions related to neuropathy according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:005524	INF	, ABCB1, ABCB4, ABCC2, ABCE1, ACVRL1
2	growth factor activity	GO:008083	12.5	TGFB1, TYMP, AGT, NGF, NRG1, NTF4
3	gap junction channel activity	GO:005243	12.0	GJD2, GJC2, GJB4, GJB3, GJB2, GJB1
4	hormone activity	GO:005179	INF	, EDN1, AGT, TTR, TG, POMC
5	protein homodimerization activity	GO:042803	INF	AGXT, G6PD, ACHE, ABP1, NFKB1, NOS2
6	protein binding	GO:005515	INF	TYR, EGR2, EGFR, EDC4, , NDUFS7
7	cytokine activity	GO:005125	INF	IFNB1, IFNG, TNF, TNFRSF11B, TNFSF11, NRG1
8	receptor binding	GO:005102	INF	NRG1, PPY, NTF3, , HLA-B, HLA-A
9	copper ion binding	GO:005507	INF	ABP1, TYR, DBH, PRNP, SOD1, TP53