MCID: NRP001
MIFTS: 61

Neuropathy malady

Neuronal diseases category
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Summaries for Neuropathy

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may impair sensation, movement,... more...

MalaCards: Neuropathy is related to autonomic neuropathy and peripheral neuropathy. An important gene associated with Neuropathy is GJB1 (gap junction protein, beta 1, 32kDa), and among its related pathways are ceramide de novo biosynthesis and Neural Crest Differentiation. The compounds mipafox and 2,3-cyclic nucleotide have been mentioned in the context of this disorder. Affiliated tissues include nerves or nerve cells, testes and heart, and related mouse phenotypes are integument and muscle.

Disease Ontology:8 A nervous system disease that is located in nerves or nerve cells.

Aliases & Classifications for Neuropathy

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuropathy 8 10 62


External Ids:

Disease Ontology8 DOID:870
NCIt40 C4731

Related Diseases for Neuropathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1178)
idRelated DiseaseScoreTop Affiliating Genes
1autonomic neuropathy31.8NGF
2peripheral neuropathy31.8WNK1, SLC12A6, SPTLC1, SPTLC2
3diabetic neuropathy31.7NGF, PMP22, MPZ
4hereditary neuropathy with liability to pressure palsies31.4PMP22
5hereditary neuropathies31.4GJB1, MTMR2, MPZ, PMP22
6hereditary sensory neuropathy31.1SPTLC1, NGF, SPTLC2
7charcot-marie-tooth disease31.1MPZ, PMP22
8brachial plexus neuropathy31.0PMP22, MPZ
9tooth disease31.0GJB1, MPZ, PMP22
10polyneuropathy30.9GAN, MPZ, GJB1, PMP22, PNPLA6
11hereditary sensory neuropathy type 130.8SPTLC1, SPTLC2
12neuritis30.7MPZ, PMP22
13charcot-marie-tooth disease type 1a30.6PMP22, CMT1A
14inherited peripheral neuropathy30.5PMP22, MPZ, GJB1
15charcot-marie-tooth neuropathy type 1a30.5PMP22, MPZ
16charcot-marie-tooth neuropathy type 130.5PMP22, MPZ
17polyradiculoneuropathy30.5PMP22
18motor peripheral neuropathy30.5PMP22, MPZ
19myopathy30.4GDAP1, PNPLA6, MFN2, NGF, PMP22, GARS
20charcot-marie-tooth disease type 4e30.4PMP22, MPZ
21sensory peripheral neuropathy30.4NGF, PMP22, MPZ, MTMR2, GJB1, SLC12A6
22chronic inflammatory demyelinating polyradiculoneuropathy30.3PMP22, MPZ
23charcot-marie-tooth neuropathy type 230.3MFN2, MPZ, GARS, GDAP1
24neuropathy, recurrent, with pressure palsies30.3CMT1A, PMP22
25charcot-marie-tooth disease type 330.3PMP22, GJB1, MPZ
26sensorineural hearing loss30.2GJB1, PMP22
27guillain-barre syndrome30.1MPZ, PMP22
28charcot-marie-tooth neuropathy type 430.1GDAP1, MTMR2
29neuropathy, inflammatory demyelinating30.0PMP22, CMT1A
30charcot-marie-tooth disease type 1e30.0PMP22, CMT1A
31pelizaeus-merzbacher disease29.9MPZ
32anterior ischemic optic neuropathy10.9
33ulnar neuropathy10.9
34axonal neuropathy10.9
35diabetic autonomic neuropathy10.9
36multifocal motor neuropathy10.9
37auditory neuropathy10.9
38leber hereditary optic neuropathy10.9
39hereditary neuropathy with liability to pressure palsy10.8
40femoral neuropathy10.8
41diabetes mellitus10.7
42giant axonal neuropathy10.7
43small fiber neuropathy10.7
44neuronitis10.6
45amyloid neuropathy10.6
46sciatic neuropathy10.6
47retinitis10.6
48peroneal neuropathy10.6
49ataxia10.6
50acute motor axonal neuropathy10.6

Graphical network of the top 20 diseases related to Neuropathy:



Diseases related to neuropathy

Symptoms for Neuropathy

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Drugs & Therapeutics for Neuropathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Neuropathy

Search NIH Clinical Center for Neuropathy

Genetic Tests for Neuropathy

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Anatomical Context for Neuropathy

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Neuropathy:

33
Testes, Heart, Skin, Brain, Eye, Bone, Liver, Spinal cord, Breast, Endothelial, Lung, T cells, Thyroid, Colon, Kidney, B cells, Bone marrow, Dorsal root ganglion, Prostate, Pituitary, Skeletal muscle, Whole blood, Pancreas, Tongue, Spleen, Salivary gland, Thalamus, Amygdala, Trigeminal ganglion, Pancreatic islet, Globus pallidus, Temporal lobe, Lymph node, Cortex, Monocytes, Smooth muscle, Small intestine, Adrenal gland

FMA organs/tissues related to Neuropathy:

14
Nerves or nerve cells

Animal Models for Neuropathy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Neuropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.9PNPLA6, NGF, KIF1A, SLC12A6, TRPV4, SPTLC2
2MP:00053698.5MFN2, PMP22, NGF, WNK1, GARS, GAN
3MP:00053768.1SPTLC2, SPTLC1, PNPLA6, MFN2, NGF, MPZ
4MP:00053787.9PNPLA6, MFN2, PMP22, NGF, WNK1, MTMR2
5MP:00107687.5PMP22, MFN2, PNPLA6, SPTLC1, SPTLC2, NGF
6MP:00053867.5NGF, PMP22, MFN2, PNPLA6, SPTLC1, MPZ
7MP:00036317.4TRPV4, SPTLC1, PNPLA6, MFN2, PMP22, NGF

Publications for Neuropathy

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Sources:
52PubMed
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Articles related to Neuropathy:

(show top 50)    (show all 6777)
idTitleAuthorsYear
1
Goshajinkigan oxaliplatin neurotoxicity evaluation (GONE): a phase 2, multicenter, randomized, doublea89blind, placeboa89controlled trial of goshajinkigan to prevent oxaliplatina89induced neuropathy. (24121454)
2013
2
Mutational analysis of the 5' non-coding region of GJB1 in a Taiwanese cohort with Charcot-Marie-Tooth neuropathy. (23827825)
2013
3
The effect of diabetic neuropathy on foot bones: a systematic review and meta-analysis. (24151985)
2013
4
Long-term evaluation of radiation-induced optic neuropathy after single-fraction stereotactic radiosurgery. (24074926)
2013
5
The correlation between pain-related behaviour and spinal microgliosis in four distinct models of peripheral neuropathy. (22467279)
2012
6
Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. (23152654)
2012
7
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CBa88 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy. (22998838)
2012
8
Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation. (22861166)
2012
9
Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. (22496202)
2012
10
Neuromuscular ultrasound in the diagnosis of focal neuropathies superimposed on polyneuropathy: a case report. (21835689)
2012
11
Common fibular (peroneal) neuropathy as the result of a ganglion cyst. (23202278)
2012
12
Acute transverse myelitis and acute motor axonal neuropathy developed after vaccinations against seasonal and 2009 A/H1N1 influenza. (21372468)
2011
13
Motor nerve conduction study in cauda equina with high-voltage electrical stimulation in multifocal motor neuropathy and amyotrophic lateral sclerosis. (21254095)
2011
14
Peripheral neuropathies: Molecular diagnosis of Charcot-Marie-Tooth disease. (21587243)
2011
15
Mutations for Leber hereditary optic neuropathy in patients with alcohol and tobacco optic neuropathy. (22194643)
2011
16
Four novel cases of periaxin-related neuropathy and review of the literature. (21079185)
2010
17
Synchronous auditory nerve activity in the carboplatin-chinchilla model of auditory neuropathy. (20649190)
2010
18
Auditory neuropathy associated with postnatally acquired cytomegalovirus infection in a very preterm infant. (22789691)
2010
19
Protection from clinical peripheral sensory neuropathy in AlstrAPm syndrome in contrast to early-onset type 2 diabetes. (19092165)
2009
20
Hereditary peripheral neuropathies]. (19327944)
2009
21
New liquid intravenous immunoglobulin (10 % IVIg) for treatment of multifocal motor neuropathy: a prospective study of efficacy, safety and tolerability. (18758888)
2008
22
The Neuropad test: a visual indicator test for human diabetic neuropathy. (18368386)
2008
23
An approach to the assessment of diabetic neuropathy based on dynamic pupillometry. (18002017)
2007
24
Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects. (17927589)
2007
25
Radial and ulnar neuropathy due to pigmented villonodular synovitis of the elbow. (17126239)
2006
26
Erectile dysfunction as a sentinel symptom of cardiovascular autonomic neuropathy in heavy drinkers. (15574133)
2004
27
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
28
Posterior ischemic optic neuropathy related to profound shock after penetrating thoracoabdominal trauma. (12356108)
2002
29
Electrodiagnosis of ulnar neuropathy at the wrist: conduction block versus traditional tests. (12177377)
2002
30
Can diabetic neuropathy be prevented by angiotensin-converting enzyme inhibitors? (10711571)
2000
31
Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome]. (10614173)
1999
32
Features of uremic neuropathy in long-term dialysis. (10097427)
1998
33
Hereditary thermosensitive neuropathy. (9674846)
1998
34
Cholecystoparesis with diabetic autonomic neuropathy. (9313105)
1997
35
Slowing of central conduction in X-linked Charcot-Marie-Tooth neuropathy shown by brain stem auditory evoked responses. (8676158)
1996
36
Operative treatment of medical epicondylitis. Influence of concomitant ulnar neuropathy at the elbow. (7608229)
1995
37
Three subgroups of patients from the United Kingdom with Leber hereditary optic neuropathy. (7821467)
1994
38
Late onset dysthyroid optic neuropathy. (7920007)
1994
39
Acute intermittent porphyria with atypical neuropathy. (2035100)
1991
40
Sparing of the flexor carpi ulnaris in ulnar neuropathy at the elbow. (1656251)
1991
41
Risk factors in nonarteritic anterior ischemic optic neuropathy. (2077825)
1990
42
Acute femoral neuropathy and iliopsoas infarction in intravenous drug abusers. (2166251)
1990
43
QT interval in diabetic autonomic neuropathy. (2147640)
1990
44
Membranous glomerulonephritis associated with chronic progressive demyelinating neuropathy. (3027615)
1987
45
Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy. (3742831)
1986
46
Axonal dystrophy in experimental diabetic autonomic neuropathy. (7160544)
1982
47
A new test to study diabetic autonomic neuropathy. (7227703)
1981
48
Hormonal, metabolic, and cardiovascular responses to hypoglycemia in diabetic autonomic neuropathy. (7018967)
1981
49
Nerve xenografts to apportion the role of axon and Schwann cell in myelinated fiber absence in hereditary sensory neuropathy, type II. (289909)
1979
50
9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy. (1094320)
1975

Variations for Neuropathy

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Expression for genes affiliated with Neuropathy

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuropathy

Search GEO for disease gene expression data for Neuropathy.

Pathways for genes affiliated with Neuropathy

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Sources:
50PathCards, 38NCBI BioSystems Database
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Pathways related to Neuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0SPTLC1, SPTLC2
29.9GJB1, MPZ, PMP22

Compounds for genes affiliated with Neuropathy

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Neuropathy according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1mipafox4510.2NGF, PNPLA6
22,3-cyclic nucleotide4510.2PNPLA6, MPZ
3dihydroprogesterone4510.2PMP22, MPZ
4l-serine61 29 24 1113.1SPTLC2, SPTLC1
53-Dehydrosphinganine2410.0SPTLC1, SPTLC2
6ganglioside4510.0PMP22, NGF, MPZ
7dihydrotestosterone45 29 24 1112.9MPZ, NGF, PMP22
8ceramide459.8NGF, SPTLC1, SPTLC2
9gaba459.6GARS, GJB1, PMP22
10cysteine459.3PMP22, NGF, MPZ, GJB1, GARS
11tyrosine459.0NGF, MPZ, WNK1, MTMR2, GJB1, GARS
12serine458.8GARS, SPTLC2, SPTLC1, PNPLA6, PMP22, NGF

GO Terms for genes affiliated with Neuropathy

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16Gene Ontology
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Cellular components related to Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine C-palmitoyltransferase complexGO:01705910.0SPTLC1, SPTLC2

Biological processes related to Neuropathy according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1sphinganine biosynthetic processGO:04651110.2SPTLC1, SPTLC2
2sphingomyelin biosynthetic processGO:00668610.2SPTLC1, SPTLC2
3sphingosine biosynthetic processGO:04651210.2SPTLC2, SPTLC1
4ceramide biosynthetic processGO:04651310.1SPTLC1, SPTLC2
5myelin assemblyGO:03228810.1MTMR2, PMP22
6neuron developmentGO:04866610.0MTMR2, WNK1
7negative regulation of neuron projection developmentGO:0109779.9PMP22, TRPV4
8peripheral nervous system developmentGO:0074229.9NGF, PMP22
9sphingolipid biosynthetic processGO:0301489.7SPTLC1, SPTLC2
10cell deathGO:0082198.9TRPV4, PNPLA6, MFN2, KIF1A, GARS, GAN

Molecular functions related to Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine C-palmitoyltransferase activityGO:00475810.0SPTLC1, SPTLC2

Products for genes affiliated with Neuropathy

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Neuropathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet