MCID: NRP037
MIFTS: 57

Neuropathy, Hereditary Sensory and Autonomic, Type V malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Gastrointestinal diseases, Ear diseases, Mental diseases

Aliases & Classifications for Neuropathy, Hereditary Sensory and Autonomic, Type V

About this section
Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 24GeneTests, 25Genetics Home Reference, 27GTR, 31ICD10 via Orphanet, 37MedGen, 39MeSH, 40MESH via Orphanet, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet, 70UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Neuropathy, Hereditary Sensory and Autonomic, Type V:

Name: Neuropathy, Hereditary Sensory and Autonomic, Type V 52 48 12
Congenital Insensitivity to Pain 11 48 24 25 70
Hsan5 48 24 25 54 70
Indifference to Pain, Congenital, Autosomal Recessive 52 25 70 68
Hsan V 48 24 25 70
Hereditary Sensory and Autonomic Neuropathy Type V 48 24 25
Channelopathy-Associated Insensitivity to Pain 24 25 70
Congenital Sensory Neuropathy with Selective Loss of Small Myelinated Fibers 25 27
Channelopathy-Associated Congenital Insensitivity to Pain 48 54
Congenital Insensitivity to Pain and Thermal Analgesia 48 54
Congenital Indifference to Pain, Autosomal Recessive 24 27
Hereditary Sensory and Autonomic Neuropathy Type 5 48 54
Hereditary Sensory and Autonomic Neuropathy 11 48
Insensitivity to Pain, Congenital 52 48
Pain Insensitivity, Congenital 25 39
Hereditary Sensory Neuropathy 11 13
Asymbolia for Pain 25 70
Hsan Type V 25 50
Cip 25 70
 
Hereditary Sensory and Autonomic Neuropathy, Type 5 25
Insensitivity to Pain, Channelopathy-Associated 12
Neuropathy, Hereditary Sensory and Autonomic, 5 70
Hereditary Sensory Autonomic Neuropathy, Type 5 68
Hereditary Sensory and Autonomic Neuropathies 68
Congenital Analgesia Autosomal Recessive 70
Hereditary Sensory Autonomic Neuropathy 48
Hereditary Sensory Neuropathy Type V 70
Indiferencia Congénita Al Dolor 48
Congenital Indifference to Pain 25
Familial Dysautonomia, Type Ii 11
Sensory Neuropathy, Hereditary 68
Sensory Neuropathy Hereditary 50
Congenital Pain Indifference 25
Hsan2d, Autosomal Recessive 52
Congenital Analgesia 25
Hsn V 70
Hsan 48

Characteristics:

Orphanet epidemiological data:

54
channelopathy-associated congenital insensitivity to pain:
Inheritance: Autosomal dominant,Autosomal recessive; Prevalence: <1/1000000 (Worldwide)
hsan5:
Inheritance: Autosomal recessive; Age of onset: Infancy,Neonatal

HPO:

64
insensitivity to pain, congenital:
Inheritance: autosomal recessive inheritance
Onset and clinical course: infantile onset
neuropathy, hereditary sensory and autonomic, type v:
Inheritance: autosomal recessive inheritance
Onset and clinical course: infantile onset

Classifications:



External Ids:

Disease Ontology11 DOID:0050548
MESH via Orphanet40 D000699, D009477
UMLS via Orphanet69 C0002768, C0020075
ICD10 via Orphanet31 G60.8

Summaries for Neuropathy, Hereditary Sensory and Autonomic, Type V

About this section
OMIM:52 Congenital indifference to pain is a rare autosomal recessive disorder characterized by the complete absence of pain... (243000) more...

MalaCards based summary: Neuropathy, Hereditary Sensory and Autonomic, Type V, also known as congenital insensitivity to pain, is related to insensitivity to pain, congenital, with anhidrosis and congenital insensitivity to pain with severe intellectual disability, and has symptoms including intellectual disability, mild, episodic fever and anosmia. An important gene associated with Neuropathy, Hereditary Sensory and Autonomic, Type V is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways are L1CAM interactions and Interaction between L1 and Ankyrins. Affiliated tissues include tongue, bone and spinal cord, and related mouse phenotypes are integument and behavior/neurological.

Disease Ontology:11 A neuropathy characterized by congenital insensitivity to pain resulting in ulceration to the fingers, tongue, lips, and other distal appendages.

UniProtKB/Swiss-Prot:70 Indifference to pain, congenital, autosomal recessive: A disorder characterized by congenital inability to perceive any form of pain, in any part of the body. All other sensory modalities are preserved and the peripheral and central nervous systems are apparently intact. Patients perceive the sensations of touch, warm and cold temperature, proprioception, tickle and pressure, but not painful stimuli. There is no evidence of a motor or sensory neuropathy, either axonal or demyelinating. Neuropathy, hereditary sensory and autonomic, 5: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.

Genetics Home Reference:25 Congenital insensitivity to pain is a condition that inhibits the ability to perceive physical pain. From birth, affected individuals never feel pain in any part of their body when injured. People with this condition can feel the difference between sharp and dull and hot and cold, but cannot sense, for example, that a hot beverage is burning their tongue. This lack of pain awareness often leads to an accumulation of wounds, bruises, broken bones, and other health issues that may go undetected. Young children with congenital insensitivity to pain may have mouth or finger wounds due to repeated self-biting and may also experience multiple burn-related injuries. These repeated injuries often lead to a reduced life expectancy in people with congenital insensitivity to pain. Many people with congenital insensitivity to pain also have a complete loss of the sense of smell (anosmia).

NIH Rare Diseases:48 Congenital insensitivity to pain is a condition, present from birth, that inhibits the ability to perceive physical pain. Affected individuals  are unable to feel pain in any part of their body. Over time, this lack of pain awareness can lead to an accumulation of injuries and health issues that may affect life expectancy. Congenital insensitivity to pain is caused by mutations in the SCN9A gene and, in rare cases, is caused by mutations in the PMRD12 gene. It is inherited in an autosomal recessive pattern.  Congenital insensitivity to pain is considered a form of peripheral neuropathy because it affects the peripheral nervous system, which connects the brain and spinal cord to muscles and to cells that detect sensations such as touch, smell, and pain. It is part of a group known as hereditary sensory and autonomic neuropathies. Last updated: 1/26/2016

Wikipedia:71 Hereditary sensory and autonomic neuropathy (HSAN) or hereditary sensory neuropathy (HSN) is a condition... more...

Description from OMIM:52 608654

Related Diseases for Neuropathy, Hereditary Sensory and Autonomic, Type V

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Diseases in the Neuropathy, Hereditary Sensory and Autonomic, Type V family:

Neuropathy, Hereditary Sensory and Autonomic, Type Vii Neuropathy, Hereditary Sensory and Autonomic, Type Iib
Neuropathy, Hereditary Sensory and Autonomic, Type Vi Neuropathy, Hereditary Sensory and Autonomic, Type Ia
Neuropathy, Hereditary Sensory and Autonomic, Type Viii Neuropathy, Hereditary Sensory and Autonomic, Type Ii
Neuropathy, Hereditary Sensory and Autonomic, Type Ic Hereditary Sensory and Autonomic Neuropathy Type 1e
Hereditary Sensory and Autonomic Neuropathy Type Iic

Diseases related to Neuropathy, Hereditary Sensory and Autonomic, Type V via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1insensitivity to pain, congenital, with anhidrosis12.2
2congenital insensitivity to pain with severe intellectual disability12.2
3congenital insensitivity to pain with hyperhidrosis12.1
4neuropathy, hereditary sensory and autonomic, type ia11.8
5neuropathy, hereditary sensory, type ie11.8
6neuropathy, hereditary sensory, type if11.6
7neuropathy, hereditary sensory, type id11.6
8neuropathy, hereditary sensory, type ib11.5
9critical illness polyneuropathy11.5
10hereditary sensory and autonomic neuropathy type 1e11.2
11neuropathy, hereditary sensory and autonomic, type ii11.1
12neuropathy, hereditary sensory and autonomic, type vii11.1
13neuropathy, hereditary sensory and autonomic, type ic11.1
14dysautonomia, familial10.9
15congenital absence of both forearm and hand, bilateral10.5SCN10A, SCN11A, SCN9A
16erythermalgia, primary10.5SCN10A, SCN11A, SCN9A
17paroxysmal extreme pain disorder10.5SCN10A, SCN11A, SCN9A
18mucolipidosis iv10.5SPTLC1, SPTLC2
19benign familial infantile epilepsy10.5SCN10A, SCN11A, SCN9A
20febrile seizures, familial, 110.5SCN10A, SCN11A
21diffuse large b-cell lymphoma10.5NGF, NTRK1, SCN9A
22tracheal stenosis10.5NTRK1, SCN10A, SCN11A
23pseudoainhum10.5NGF, NGFR
24papillary serous adenocarcinoma10.5NGF, NTRK1, NTRK2
25thyroid hormone metabolism, abnormal10.4NAA50, SPTLC1
26hypermobility of coccyx10.4NGFR, SCN10A
27pharynx carcinoma in situ10.4NGF, NTRK1
28pulmonary embolism10.4NGFR, SCN10A
29neonatal respiratory failure10.4NGF, NGFR, NTRK1
30autonomic neuropathy10.4
31neuropathy10.4
32c5 deficiency10.3IKBKAP, NGF, NTRK1, NTRK2
33epileptic hemiplegia10.3IKBKAP, NTRK1
34benign focal amyotrophy10.3FAM134B, SCN9A, SPTLC1, WNK1
35hemophagocytic lymphohistiocytosis, familial, 510.3NAA50, SPTLC1
36nephrotic syndrome, type 610.3FAM134B, IKBKAP, SCN9A, WNK1
37esophagitis10.2NGF, NGFR, NTRK1, NTRK2
38interstitial emphysema10.0NAA50, SPTLC1
39rumination disorder9.8FAM134B, IKBKAP, NGF, NTRK1, SPTLC1, SPTLC2
40lymphoma9.8
41polyneuropathy9.8
42lung cancer9.6
43breast cancer9.6
44hyperprolactinemia9.6
45pancreatic cancer9.6
46testicular germ cell tumor9.6
47acute leukemia9.6
48b-cell lymphomas9.6
49leukemia9.6
50oral squamous cell carcinoma9.6

Graphical network of the top 20 diseases related to Neuropathy, Hereditary Sensory and Autonomic, Type V:



Diseases related to neuropathy, hereditary sensory and autonomic, type v

Symptoms & Phenotypes for Neuropathy, Hereditary Sensory and Autonomic, Type V

About this section

Symptoms by clinical synopsis from OMIM:

243000

Clinical features from OMIM:

608654,243000

Human phenotypes related to Neuropathy, Hereditary Sensory and Autonomic, Type V:

 64 (show all 11)
id Description HPO Frequency HPO Source Accession
1 intellectual disability, mild64 rare (5%) HP:0001256
2 episodic fever64 rare (5%) HP:0001954
3 anosmia64 HP:0000458
4 hyporeflexia64 HP:0001265
5 painless fractures due to injury64 HP:0002661
6 hyposmia64 HP:0004409
7 pain insensitivity64 HP:0007021
8 self-mutilation64 HP:0000742
9 anhidrosis64 HP:0000970
10 acral ulceration and osteomyelitis leading to autoamputation of digits64 HP:0001226
11 acral ulceration and osteomyelitis leading to autoamputation of the digits (feet)64 HP:0001862

UMLS symptoms related to Neuropathy, Hereditary Sensory and Autonomic, Type V:


anosmia, sense of smell impaired

MGI Mouse Phenotypes related to Neuropathy, Hereditary Sensory and Autonomic, Type V according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.4FAM134B, IKBKAP, NGF, NGFR, NTRK1, SCN10A
2MP:00053868.6FAM134B, IKBKAP, NGF, NGFR, NINJ1, NTRK1
3MP:00036317.8FAM134B, IKBKAP, NGF, NGFR, NINJ1, NTRK1

Drugs & Therapeutics for Neuropathy, Hereditary Sensory and Autonomic, Type V

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Drugs for Neuropathy, Hereditary Sensory and Autonomic, Type V (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 92)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Guaifenesinapproved, vet_approvedPhase 461693-14-13516
Synonyms:
3-(2-Methoxyphenoxy)-1,2-propanediol
3-(O-Methoxyphenoxy)-1,2-propanediol
3-(O-Methoxyphenoxy)-propanediol-1,2
3-O-Methoxyphenoxypropane 1:2-diol
Actifed C
Aeronesin
Amonidren
Amonidrin
Aresol
Benylin-E
Bronchol
Glycerin ether
Glycerin guaiacolate
Glycero-guaiacol ether
Glycerol a-(2-methoxyphenyl) ether
Glycerol a-(O-methoxyphenyl)ether
Glycerol a-guaiacyl ether
Glycerol a-guiacyl ether
Glycerol a-monoguaiacol ether
Glycerol guaiacolate
Glycerol mono(2-methoxyphenyl) ether
Glycerol-a-guajakolether
Glycerol-alpha-guajakolether
Glyceryl guaiacol
Glyceryl guaiacol ether
Glyceryl guaiacolate
Glyceryl guaiacolate ether
Glyceryl guaiacyl ether
Glyceryl guaicolate
Glyceryl guiacolate
 
Glycerylguaiacol
Guaiacol glycerol ether
Guaiacol glyceryl ether
Guaiacolglicerinetere
Guaiacuran
Guaiacurane
Guaiacyl glyceryl ether
Guaiamar
Guaianesin
Guaicol glycerine ether
Guaicol glyceryl ether
Guaifenesin
Guaifenesine
Guaiphenesin
Guaiphenesine
Guaiphesin
Hustosil
Methoxypropanediol
Methphenoxydiol
Metossipropandiolo
O-Methoxyphenyl glyceryl ether
Organidin NR
Pneumomist
Propanosedyl
Reduton
Robitussin
a-Glyceryl guaiacol ether
a-Glyceryl guaiacolate ether
alpha-Glyceryl guaiacol ether
alpha-Glyceryl guaiacolate ether
guaiphenesin
p-Cresyl acetate
2
KetorolacapprovedPhase 430474103-06-3, 66635-83-43826
Synonyms:
(+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
(+-)-Ketorolac
(+-)-isomer
(.+/-.)-2,3-Dihydro-5-benzoyl-1H-pyrrolizine-1-carboxylic acid
1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro
5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
5-Benzoyl-1,2-dihydro-3H-pyrrolo(1,2a)pyrrole-1-carboxylic acid
5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
66635-83-4
74103-06-3
AB00053682
AC-545
AC1L1GSW
BRD-A40639672-234-05-7
C07062
CHEBI:105080
CHEMBL469
CID3826
D020910
D08104
DB00465
 
I14-2832
Ketoralac
Ketorolac
Ketorolac (INN)
Ketorolac Tromethamine
Ketorolac [INN:BAN]
Ketorolaco
Ketorolaco [Spanish]
Ketorolacum
Ketorolacum [Latin]
Kétorolac
LS-139094
Macril
MolPort-005-933-093
NCGC00185990-01
RS 37619
RS-37619
SBB067312
STL018674
Toradol (TN)
UNII-YZI5105V0L
ketorolac
rac-Ketorolac
3
Hydromorphoneapproved, illicitPhase 4, Phase 3, Phase 2176466-99-95284570
Synonyms:
(-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphinan-6-one
(-)-Hydromorphone
(5alpha)-3-hydroxy-17-methyl-4,5-epoxymorphinan-6-one
18145-12-5
3-hydroxy-17-methyl-4,5alpha-epoxymorphinan-6-one
4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one
4,5alpha-Epoxy-3-hydroxy-17-methyl-6-morphinanone
41376-02-7
466-99-9
6-Deoxy-7,8-dihydro-6-oxomorphine
7,8-Dihydromorphinone
C07042
CHEBI:5790
CHEMBL398707
CID5284570
D08047
DB00327
DEA No. 9150
DiMo
Dihydromorfinon
Dihydromorfinon [Czech]
Dihydromorphinone
Dilaudid
Dilaudid Oros
Dilaudid-hp
Dimorphone
 
EINECS 207-383-5
HSDB 3341
Hidromorfona
Hidromorfona [INN-Spanish]
Hydromorfona
Hydromorfona [Spanish]
Hydromorphon
Hydromorphone
Hydromorphone (INN)
Hydromorphone HCL
Hydromorphone [INN:BAN]
Hydromorphonum
Hydromorphonum [INN-Latin]
Idromorfone
Idromorfone [DCIT]
LS-187185
LS-92152
Laudacon
Laudicon
MolPort-004-285-951
Morphinan-6-one, 4,5alpha-epoxy-3-hydroxy-17-methyl- (8CI)
NSC 19046
NSC19046
Novolaudon
UNII-Q812464R06
WLN: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ JQ P1
hydromorphone
4
Morphineapproved, investigationalPhase 4, Phase 3, Phase 296057-27-25288826
Synonyms:
(-)(5.alpha.,6.alpha.)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(-)-Heroin hydrochloride
(-)-Morphine
(-)Morphine sulfate
(5R,6S,9R,13S,14R)-4,5-Epoxy-N-methyl-7-morphinen-3,6-diol
(5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol
(5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol
(5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5alpha,6alpha)-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5α,6α)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol
(5α,6α)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL
(7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol
(−)-morphine
17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol
4,5alpha-Epoxy-17-methyl-7-morphinen-3,6alpha-diol
4-methyl-(13R,14S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol
47106-99-0
57-27-2
6211-15-0 (sulfate (2:1) (salt) pentahydrate)
64-31-3
64-31-3 (sulfate (2:1) (salt) anhydrous)
7,8-Didehydro-4,5-epoxy-17-methyl-morphinan-3,6-diol
7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
8053-16-5
85201-37-2
Apokyn
Astramorph PF
Avinza
BIDD:GT0147
C01516
CCRIS 5762
CHEBI:17303
CHEMBL70
CID5288826
Cube juice
D-(-)-Morphine
DB00295
DEA No. 9300
DepoDur
Depodur
Diacetylmorphine hydrochloride
Diamorphine hydrochloride
Dolcontin
Dreamer
Dulcontin
Duramorph PF
Duromorph
EINECS 200-320-2
Epimorph
HSDB 2134
Hard stuff
Heroin hydrochloride
Heroine hydrochloride
Hocus
 
Infumorph
Kadian
LS-91748
M-Eslon
M.O.S
MOI
MORPHINE SULFATE
MORPHINE, (5A,6A)-7,8-DIDEHYDRO-4,5-EPOXY-17-METHYLMORPHINIAN-3,6-DIOL, MORPHIUM, MORPHIA, DOLCONTIN, DUROMORPH, MORPHINA, NEPENTHE
MS Contin
MS/L
MS/S
MSIR
Meconium
MolPort-003-849-273
Morfina
Morfina [Italian]
Morphia
Morphin
Morphin [German]
Morphina
Morphina [Italian]
Morphine Extra-Forte
Morphine Forte
Morphine H.P
Morphine Sulfate
Morphine [BAN]
Morphinism
Morphinum
Morphitec
Morphium
Morpho
Moscontin
Ms Contin
Ms Emma
NSC11441
Nepenthe
O,O'-Diacetylmorphine hydrochloride
OMS Concentrate
Oramorph SR
Ospalivina
RMS
RMS Uniserts
Rescudose
Roxanol
Roxanol 100
Roxanol UD
SDZ 202-250
SDZ202-250
Statex
Statex Drops
Statex SR
UNII-76I7G6D29C
Unkie
l-Morphine
morfina
morphine
nchembio.317-comp1
nchembio.64-comp1
5
Codeineapproved, illicitPhase 47476-57-35284371
Synonyms:
(-)-Codeine
(5alpha,6alpha)-17-methyl-3-(methyloxy)-7,8-didehydro-4,5-epoxymorphinan-6-ol
(5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
(5α,6α)-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
(6alpha,13alpha)-3-methoxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-ol
(−)-Codeine
3-Methylmorphin
3-methoxy-17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-6alpha-ol
3-methylmorphine
3-o-methylmorphine monohydrate
41444-62-6 (PO4)
7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methylmorphinan-6-alpha-ol
7,8-didehydro-4,5-ep oxy-3-methoxy-17-methylmorphinan-6-ol
7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-(5alpha, 6alpha)-morphinan 6-ol
7,8-didehydro-4,5alpha-epoxy-3-methoxy-17-methylmorphinan-6alpha-ol
7,8-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol
76-57-3
AC-11114
AC1Q4DTD
Actacode
Ardinex
C06174
C1653_FLUKA
C1653_SIGMA
C5901_FLUKA
C5901_SIGMA
CCRIS 7555
CHEBI:16714
CHEMBL485
CID5284371
CODEINE (SEE ALSO: CODEINE PHOSPHATE (CAS 52-28-8))
CODEINE BASE
Calcidrine
Codalgin Forte Codate
Codein
Codeine
Codeine (anhydrous)
Codeine [BAN]
Codeine anhydrous
Codeine solution
 
Codeinum
Codeína
Codicept
Coducept
Codéine
DB00318
EINECS 200-969-1
HSDB 3043
Isocodeine
L-Codeine
LS-1695
Methylmorphine
MolPort-002-506-913
Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5-alpha,6-alpha)- (9CI)
Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)- (9CI)
Morphinan-6alpha-ol, 7,8-didehydro-4,5alpha-epoxy-3-methoxy-17-methyl- (8CI)
Morphine 3-methyl ether
Morphine monomethyl ether
Morphine-3-methyl ester
Morphine-3-methyl ether
N-Methylmorphine
N-methyl norcodine
N-methylnorcodeine
Norcodeine, N-Methyl
Norcodeine, N-methyl
Norcodine, N-Methyl
Norcodine, N-methyl
Novahistine DH
O(3)-methylmorphine
O3-Methylmorphine
Robitussin AC
STOCK1N-42851
codeina
codeine
codeinum
l-Codeine
metilmorfina
morphine 3-methyl ether
morphine monomethy l ether
morphine monomethyl ether
morphine-3-methyl ether
nchembio.317-comp2
6
Bupivacaineapproved, investigationalPhase 4, Phase 3, Phase 211312180-92-9, 38396-39-32474
Synonyms:
( inverted exclamation markA)-bupivacaine
(+-)-Bupivacaine
(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(RS)-bupivacaine
(±)-bupivacaine
1-Butyl-2',6'-pipecoloxylidide
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
15233-43-9
2180-92-9
38396-39-3
AB00053674
AC-2096
AC1L1DRE
AC1Q5LX4
AH 250
AKOS001637202
AR-1A0242
Anekain
BPBio1_000298
BRD-A01636364-003-05-2
BSPBio_000270
BSPBio_002607
Bio-0886
Bloqueina
Bucaine
Bucaine (TN)
Bupivacaina
Bupivacaina [INN-Spanish]
Bupivacaine (INN)
Bupivacaine Carbonate
Bupivacaine HCL
Bupivacaine HCL KIT
Bupivacaine Monohydrochloride, Monohydrate
Bupivacaine [INN:BAN]
Bupivacainum
Bupivacainum [INN-Latin]
Bupivan
C07529
C18H28N2O
CBupivacaine
CHEBI:3215
CHEMBL1098
CID2474
Carbostesin
D07552
DB00297
DL-Bupivacaine
DUR-843
 
DepoBupivacaine
DivK1c_000758
EINECS 218-553-3
EINECS 253-911-2
HMS2090F12
IDI1_000758
KBio1_000758
KBio2_002004
KBio2_004572
KBio2_007140
KBio3_001827
KBioGR_001516
KBioSS_002004
KST-1A4609
L000695
LAC-43
LS-109841
LS-2222
MLS001361336
Marcaina
Marcaine
Marcaine HCL
Marcaine Spinal
MolPort-004-955-820
NCGC00178579-01
NCGC00178579-02
NINDS_000758
NSC119660
Prestwick0_000305
Prestwick1_000305
Prestwick2_000305
Prestwick3_000305
SMR000058218
SPBio_001558
SPBio_002489
Sensorcaine
Sensorcaine-MPF
Sensorcaine-MPF Spinal
Spectrum2_001589
Spectrum3_000974
Spectrum4_001098
Spectrum5_001483
Spectrum_001524
Transdur-Bupivacaine
UNII-Y8335394RO
Win 11318
Win 11318 HCl
bupivacaine
cBupivacaine
dl-1-Butyl-2',6'-pipecoloxylidide
racemic bupivacaine
7
Dexmedetomidineapproved, vet_approvedPhase 4, Phase 3, Phase 254076631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
8
RopivacaineapprovedPhase 474184057-95-471273, 175805
Synonyms:
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
(S)-(−)-1-propyl-2',6'-pipecoloxylidide
(S)-ropivacaine
84057-95-4
98717-15-8
AC1L41QM
AC1L41QN
BIDD:GT0203
C07532
C17H26N2O.HCl
CHEBI:8890
CHEMBL1077896
CID175804
CID175805
CPD000469137
D08490
I14-176
L-N-n-propylpipecolic acid-2,6-xylidide
LS-113954
 
MLS001401363
MolPort-003-983-292
NCGC00164597-01
Naropin
Naropin (TN)
ROPIVACAINE HCl
Ropivacaina
Ropivacaina [INN-Spanish]
Ropivacaina [Spanish]
Ropivacaine
Ropivacaine [INN]
Ropivacaine hydrochloride
Ropivacaine monohydrochloride
Ropivacainum
Ropivacainum [INN-Latin]
S-Ropivacaine
SAM001246524
SMR000469137
ST51051452
ropivacaine monohydrochloride,
ropivacaine monohydrochloride, (S)-isomer
9
Fentanylapproved, illicit, investigational, vet_approvedPhase 4, Phase 3, Phase 2773437-38-73345
Synonyms:
1-Phenethyl-4-(N-phenylpropionamido)piperidine
1-Phenethyl-4-N-propionylanilinopiperidine
1-phenethyl-4-N-propionylanilinopiperidine
437-38-7
5-22-08-00049 (Beilstein Handbook Reference)
80832-90-2
990-73-8 (citrate)
AC1L1FQ2
Actiq
BIDD:GT0555
BRN 0494484
CHEBI:119915
CHEMBL596
CID3345
D00320
DB00813
Duragesic
Duragesic (TN)
Duragesic-100
Duragesic-12
Duragesic-25
Duragesic-50
Duragesic-75
Durogesic
EINECS 207-113-6
Fentanest
Fentanil
Fentanil [DCIT]
Fentanila
Fentanila [INN-Spanish]
Fentanilo
Fentanyl
Fentanyl (JAN/USAN/INN)
Fentanyl CII
Fentanyl [INN:BAN]
Fentanyl citrate
Fentanyl-100
Fentanyl-12
Fentanyl-25
 
Fentanyl-50
Fentanyl-75
Fentanylum
Fentanylum [INN-Latin]
HSDB 3329
IONSYS
JNS020QD
L001275
LS-124439
Matrifen
MolPort-003-847-369
N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-Phenethyl-4-piperidyl)propionanilide
N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide
N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide
N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-phenethyl-4-piperidyl)propionanilide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropanamide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide
N-Phenethyl-4-(N-propionylanilino)piperidine
N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenethyl-4-(N-propionylanilino)piperidine
N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
NCGC00168252-01
Nasalfent
Oprea1_152073
Oprea1_207148
PDSP1_000860
PDSP2_000846
Pentanyl
Phentanyl
Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)- (9CI)
R 4263
Rapinyl
Sentonil
Sublimase
Sublimaze
UNII-UF599785JZ
fentanyl
10
IbuprofenapprovedPhase 4, Phase 250115687-27-13672
Synonyms:
(+-)-2-(P-Isobutylphenyl)propionic acid
(+-)-Ibuprofen
(+-)-P-Isobutylhydratropic acid
(+-)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
(4-Isobutylphenyl)-alpha-methylacetic acid
(RS)-ibuprofen
139466-08-3
15687-27-1
2-(4-Isobutylphenyl)propanoic acid
4-Isobutylhydratropic acid
58560-75-1
AC-11312
AC1L1GGE
AC1Q1P84
AC1Q1P85
ACHES-N-PAIN
ARONIS23835
Act-3
Actiprofen
Adex 200
Adran
Advil
Advil (TN)
Advil Liqui-Gels
Ak+C2278tren
Alaxan
Algofen
Am-Fam 400
Amelior
Amersol
Amibufen
Anafen
Anco
Andran
Anflagen
Antagil
Antalfene
Antarene
Antiflam
Apo-Ibuprofen
Apsifen
Apsifen-F
Artofen
Artril
Artril 300
BB_SC-1358
BIDD:GT0050
BRN 2049713
Balkaprofen
Betaprofen
Bloom
Bluton
Brofen
Brufanic
Brufen
Brufen 400
Bruflam
Brufort
Buburone
Bufeno
Bufigen
Bukrefen
Bupron
Buracaps
Burana
Butylenin
C01588
C13H18O2
CCRIS 3223
CHEBI:5855
CHEMBL521
CID3672
CPD000058184
Cap-Profen
Carol
Cesra
Children's Advil
Children's Elixsure
Children's Ibuprofen
Children's Motrin
Citalgan
Cobo
Codral
Combiflam
Cunil
D00126
D007052
DB01050
DOLO PUREN
Daiprophen
Dalsy
Dansida
Deep Relief
Dentigoa
Dibufen
Dignoflex
Dolgin
Dolgirid
Dolgit
Dolibu
Dolmaral
Dolo-Dolgit
Dolo-dolgit
Dolocyl
Dolofen
Dolofen-F
Dolofin
Dolofort
Dologel
Dolomax
Doloren
Dolormin
Doltibil
Dolven
Donjust B
Dorival
Drin
Duafen
Duobrus
Dura-Ibu
Duralbuprofen
Dysdolen
EU-0100691
Easifon
Ebufac
Emflam
Emflam-200
Emodin
Epobron
Eputex
Ergix
Esprenit
Exneural
Faspic
Femadon
Femafen
Femapirin
Femidol
Fenbid
Fenbid Spansule
Fendol
Fenspan
Fibraflex
Gelufene
Gofen
Grefen
Gynofug
HMS1920F15
HMS2089P05
HMS2091N03
HMS502M09
HSDB 3099
Haltran
I 4883
I01-7039
I0415
I4883_SIGMA
I7905_SIAL
IB-100
IDI1_000887
IP 82
IP-82
IP82
Ibol
Ibren
Ibu
Ibu-Attritin
Ibu-Slo
Ibu-Tab
Ibu-Tab 200
Ibu-attritin
Ibu-slo
Ibu-slow
Ibubest
Ibubeta
Ibucasen
Ibudol
 
Ibudolor
Ibufen
Ibuflamar
Ibufug
Ibugel
Ibugen
Ibugesic
Ibuhexal
Ibulagic
Ibular
Ibulav
Ibuleve
Ibulgan
Ibumed
Ibumerck
Ibumetin
Ibupirac
Ibuprin
Ibuprocin
Ibuprofen
Ibuprofene
Ibuprofeno
Ibuprofenum
Ibuprohm
Ibuprophen
Ibusal
Ibutid
Ifen
Inabrin
Inflam
Inoven
Ipren
Irfen
Isodol
Jenaprofen
Junifen
Junior Strength Advil
Junior Strength Ibuprofen
Junior Strength Motrin
KBio1_000887
KBio2_001329
KBio2_003897
KBio2_006465
KBio3_001390
Kesan
Kratalgin
LS-7454
Lamidon
Lebrufen
Librofem
Lidifen
Liptan
Lopane
MLS000069733
MLS001146965
Malafene
Manypren
Medipren
Melfen
Mensoton
Midol
Midol 200
Moment
Motrin
Motrin (TN)
Motrin IB
Mynosedin
NCI60_002065
NINDS_000887
NSC 256857
NSC256857
Nagifen-D
Napacetin
Narfen
Neo-Helvagit
Neo-Mindol
NeoProfen
Neobrufen
Nerofen
Noalgil
Nobafon
Nobfelon
Nobfen
Nobgen
Noritis
Norton
Novadol
Novo-Profen
Novogent
Novogent N
Novoprofen
Nuprilan
Nuprin
Nurofen
Optifen
Opturem
Oralfene
Ostarin
Ostofen
Ozonol
P-Isobutylhydratropic Acid
Paduden
Panafen
Pantrop
Para-Isobutylhydratropic Acid
Paxofen
Pedia-Profen
PediaProfen
Pediaprofen
Pediatric Advil
Perofen
Proartinal
Profen
Proflex
Provon
Quadrax
R.D. 13621
RD 13621
Rafen
Ranofen
Rebugen
Relcofen
Rhinadvil
Rofen
Roidenin
Rufen
Rufin
Rupan
SAM002264619
SMR000058184
SPBio_000178
STK177358
Sadefen
Salivia
Salprofen
Seclodin
Sednafen
Seklodin
Seskafen
Siyafen
Solpaflex
Solufen
Stelar
Sugafen
Suprafen
Suspren
Syntofene
TL8001184
Tab-Profen
Tabalon
Tabalon 400
Tatanal
Tempil
Tofen
Togal N
Tonal
Trendar
U 18573
U-18,573
U-18573
UCB 79171
Unipron
Upfen
Uprofen
Urem
VUFB 9649
Zafen
Zofen
alpha-(4-Isobutylphenyl)propionate
alpha-(4-Isobutylphenyl)propionic acid
alpha-(P-Isobutylphenyl)propionic acid
alpha-p-Isobutylphenylpropionate
alpha-p-Isobutylphenylpropionic acid
ibuprofen
p-Isobutyl-2-phenylpropionate
p-Isobutyl-2-phenylpropionic acid
p-Isobutylhydratropate
p-Isobutylhydratropic acid
11
Sufentanilapproved, investigationalPhase 417556030-54-741693
Synonyms:
56030-54-7
60561-17-3 (citrate)
AC1L26AJ
AC1Q5I7B
C08022
C22H30N2O2S
CHEBI:127638
CHEBI:9316
CHEMBL658
CID41693
Chronogesic
D05938
DB00708
HSDB 6760
L000580
LS-175693
MolPort-004-286-008
N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenylpropanamide
N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)propionanilide
 
N-[4-(methoxymethyl)-1-(2-thiophen-2-ylethyl)piperidin-4-yl]-N-phenylpropanamide
N-{4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]piperidin-4-yl}-N-phenylpropanamide
N-{4-[(methyloxy)methyl]-1-[2-(2-thienyl)ethyl]piperidin-4-yl}-N-phenylpropanamide
Oprea1_120838
Oprea1_246787
PDSP1_001741
PDSP2_001724
R 30730
R-30730
SUFENTANIL
Sufentanil
Sufentanil (USAN/INN)
Sufentanil Citrate
Sufentanil [USAN:BAN:INN]
Sufentanilo
Sufentanilum
Sufentanilum [INN-Latin]
Sufentanyl
Sulfentanil
Sulfentanyl
UNII-AFE2YW0IIZ
12
Epinephrineapproved, vet_approvedPhase 493351-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
13
Oxycodoneapproved, illicit, investigationalPhase 436476-42-65284603
Synonyms:
(-)-14-Hydroxydihydrocodeinone
(-)-Oxycodone
(5alpha)-14-hydroxy-17-methyl-3-(methyloxy)-4,5-epoxymorphinan-6-one
124-90-3 (hydrochloride)
14-Hydroxydihydrocodeinone
14-hydroxy-3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one
25333-72-6 (Terephthalate)
4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5.alpha.-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
76-42-6
AC-16043
AC1Q4DTG
BRN 0043446
C08018
CHEBI:7852
CHEMBL656
CID5284603
Combunox
D05312
DB00497
DEA No. 9143
Dihydro-14-hydroxycodeinone
Dihydrohydroxycodeinone
Dihydrohydroxycondeinone
Dihydrone
Dihydroxycodeinone
Dinarkon
Diphydrone
EINECS 200-960-2
Endine (Australia)
Endocet
Endodan
Endone
Eubine
Eubine [France]
Eucodal
Eucodalum
Eukodal
Eutagen
HSDB 3142
Hydroxycodeinon
LS-92148
MolPort-004-285-989
Morphinan-6-one, 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methyl- (8CI)
NSC 19043
NSC19043
 
Ossicodone
Ossicodone [DCIT]
Oxanest
Oxicodona
Oxicodona [INN-Spanish]
Oxicon
Oxicone
Oxiconum
Oxikon
OxyFAST
OxyIR
OxyNorm
Oxycodeinon
Oxycodeinone
Oxycodon
Oxycodone
Oxycodone (USAN/INN)
Oxycodone Concentrate
Oxycodone Hcl
Oxycodone Hydrochloride
Oxycodone [USAN:INN:BAN]
Oxycodone hydrochloride
Oxycodonum
Oxycodonum [INN-Latin]
Oxycon
Oxycone
Oxycontin
Oxyfast
Oxynorm
PTI-821
Pancodine
Pancodone retard (United Kingdom)
Percobarb
Percodan
Percolone
Remoxy
Roxicet
Roxicodone
Supendol
Supendol [Canada]
Supeudol
Tecodin
Tekodin
Tekodin (free base)
Thecodine
Thekodin
Theocodin
UNII-CD35PMG570
WLN: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ CQ JO1 P1
oxycodone
14
Heroinapproved, illicitPhase 4113561-27-35462328
Synonyms:
(5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate (ester)
3,6-Diacetylmorphine
7,8-Dihydro-4,5-alpha-epoxy-17-methylmorphinan-3,6-alpha-diol diacetate
Diacetylmorphine
 
Diamorphine
O,O'-Diacetylmorphine
Smack
diacetylmorphine
diamorphine
15AnalgesicsPhase 4, Phase 3, Phase 211287
16AnestheticsPhase 4, Phase 3, Phase 29001
17Pharmaceutical SolutionsPhase 4, Phase 17793
18Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 222776
19Adrenergic AgentsPhase 4, Phase 3, Phase 25140
20Adrenergic AgonistsPhase 4, Phase 3, Phase 22877
21Adrenergic alpha-AgonistsPhase 4, Phase 3, Phase 21625
22Neurotransmitter AgentsPhase 4, Phase 2, Phase 317734
23Hypnotics and SedativesPhase 4, Phase 3, Phase 22485
24Adrenergic alpha-2 Receptor AgonistsPhase 4, Phase 3, Phase 2911
25Anti-Inflammatory AgentsPhase 4, Phase 210355
26NarcoticsPhase 4, Phase 3, Phase 23486
27Respiratory System AgentsPhase 44818
28Chlorpheniramine, phenylpropanolamine drug combinationPhase 4616
29Central Nervous System DepressantsPhase 4, Phase 3, Phase 212806
30Analgesics, OpioidPhase 4, Phase 3, Phase 23091
31Antitussive AgentsPhase 4520
32Excitatory Amino Acid AntagonistsPhase 4, Phase 2, Phase 31282
33Anesthetics, LocalPhase 4, Phase 3, Phase 23272
34Anesthetics, IntravenousPhase 4, Phase 3, Phase 22406
35Excitatory Amino AcidsPhase 4, Phase 2, Phase 31297
36Ketorolac TromethaminePhase 4304
37Anesthetics, GeneralPhase 4, Phase 3, Phase 22787
38Adjuvants, AnesthesiaPhase 4, Phase 3, Phase 21588
39Analgesics, Non-NarcoticPhase 4, Phase 3, Phase 26260
40RacepinephrinePhase 4933
41Fibrin Tissue AdhesivePhase 4145
42CoagulantsPhase 41428
43HemostaticsPhase 41359
44Anti-Inflammatory Agents, Non-SteroidalPhase 4, Phase 24295
45Epinephryl boratePhase 4933
46Cyclooxygenase InhibitorsPhase 4, Phase 22778
47Antirheumatic AgentsPhase 4, Phase 210627
48CarticainePhase 424
49TeaNutraceuticalPhase 4317
50
Ketamineapproved, vet_approvedPhase 2, Phase 35286740-88-13821
Synonyms:
(+-)-Ketamine
(+/-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
(+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
(+/-)-Ketamine
(-)-Ketamine
(S)-(-)-Ketamine
(S)-Ketamine
(±)-ketamine
100477-72-3
2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone
2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)-cyclohexanone
2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(o-chlorophenyl)-2-(methylamino)-cyclohexanone
33643-45-7
6740-88-1
79499-51-7
AC1L1GSH
AC1Q40UR
AKOS001053247
BRN 2216965
C07525
C13H16ClNO
CHEBI:138833
CHEBI:6121
CHEMBL742
CI 581 base
CI-581
CID3821
CLSTA 20
Calypsol
Cetamina
Cetamina [INN-Spanish]
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)- (9CI)
Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)- (9CI)
Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+/-)- (8CI)
D08098
DB01221
DEA No. 7285
 
DL-ketamine
DivK1c_000217
EINECS 229-804-1
Esketamine
Green
IDI1_000217
KBio1_000217
KETAMINE
KETAMINE HCL
Ketaject
Ketalar
Ketalar base
Ketamina
Ketamine (INN)
Ketamine Base
Ketamine HCL
Ketamine [INN:BAN]
Ketaminum
Ketaminum [INN-Latin]
Ketanest
Ketoject
Ketolar
L-Ketamine
LS-57301
MLS001331674
MolPort-001-838-070
NCGC00159480-02
NCGC00159480-03
NINDS_000217
NMDA
NSC 70151
NSC70151
SMR000238141
Special K
Special K [street name]
Special k
T385
Tekam
Tekam (TN)
UNII-690G0D6V8H
dl-Ketamine
ketamine
l-Ketamine

Interventional clinical trials:

(show top 50)    (show all 51)
idNameStatusNCT IDPhase
1Double Blind Randomized Study Into the Efficacy of Codeine Phosphate Analgesia After Cleft Palate Repair in InfantsCompletedNCT00386269Phase 4
2Comparison of IV PCA and Wound Infusion After Repair of Pectus ExcavatumCompletedNCT01908491Phase 4
3Sub-Paraspinal Block in Nuss Patients. A Pilot ProjectCompletedNCT02169297Phase 4
4Pudendal Block Versus Caudal Block for HypospadiasCompletedNCT02390388Phase 4
5Post Operative Pain Control Using Ropivacaine and the ON-Q System in the Adult Pectus Excavatum Patient After Minimally Invasive RepairCompletedNCT01816477Phase 4
6Ultrasound Guided Intermediate Cervical Plexus Block for Congenital Muscular TorticollisRecruitingNCT02651311Phase 4
7Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in NeurosurgeryRecruitingNCT02552459Phase 4
8A Comparison Trial Between PCA and Epidural Analgesia for Pectus Excavatum RepairRecruitingNCT02056301Phase 4
9Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart SurgeryRecruitingNCT01536717Phase 4
10The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate SurgeryRecruitingNCT02953145Phase 4
11Effects of Dexmedetomidine as Adjunct to Pudendal Block for Pediatric Penile SurgeryNot yet recruitingNCT02848157Phase 4
12Dexmedetomidine vs Placebo for Pediatric Cleft Palate RepairNot yet recruitingNCT02915042Phase 4
13Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & MorphineTerminatedNCT00880373Phase 4
14Assessment of Opioid Analgesia in Sickle CellWithdrawnNCT00513864Phase 4
15Effects of Additional Fentanyl to Epidural Bupivacaine for Post-Thoracotomy Pain in NeonatesCompletedNCT00286143Phase 3
16Infra-orbital Nerve Block for Post Operative Analgesia in Children Undergoing Cleft Lip Surgery.CompletedNCT02514980Phase 2, Phase 3
17Dexmedetomidine Infusion in Hypospadias SurgeryCompletedNCT00926705Phase 3
18Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer PainCompletedNCT00538850Phase 3
19Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate SurgeryCompletedNCT02923869Phase 2, Phase 3
20Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates EquallyActive, not recruitingNCT01380197Phase 3
21THE IMPROVE TRIAL: Improving Pain Management and Outcomes With Various Strategies of Patient-Controlled Analgesia (PCA)TerminatedNCT00999245Phase 3
22Caudal Versus Intravenous Dexmedetomidine for Supplementation of Caudal Analgesia in ChildrenCompletedNCT01701778Phase 2
23Association of Different Doses of Clonidine in Caudal Epidural Anesthesia for Hypospadias SurgeryCompletedNCT02769390Phase 2
24Nitrous Oxide Analgesia Vaso-occlusive CrisisRecruitingNCT01891812Phase 2
25A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and AnhidrosisWithdrawnNCT02624310Phase 2
26Comparison of Patient Controlled Analgesia (PCA) Versus Bolus Narcotic Therapy for the Treatment of Vaso-Occlusive Crisis (VOC)WithdrawnNCT00711698Phase 2
27Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain CrisisWithdrawnNCT01932554Phase 2
28tDCS Associated With Peripheral Electrical Stimulation for Pain Control in Individuals With Sickle Cell DiseaseRecruitingNCT02813629Phase 1
29Sucrose Analgesia in Infants Undergoing Casting for Club FootUnknown statusNCT01050088
30SPAIN Chest Wall Deformity Project (Pectus Repair)Unknown statusNCT02098681
31The Management of Postoperative Craniotomy Pain in Pediatric PatientsUnknown statusNCT01576601
32The Effect of Gender on the Consumption of Pain Medication in Infants Undergoing Craniosynostosis Repair or Untethering of Cord in ITUUnknown statusNCT01996163
33Comparison of Levobupivacaine, Ropivacaine and Bupivacaine in Epidural AnaesthesiaCompletedNCT02513433
34Review of Pain Management After Congenital Cardiac SurgeryCompletedNCT01378663
35Effect of Preemptive Epidural Analgesia in Labor on Cytokine ProductionCompletedNCT00361712
36Mental Training and ChildbirthCompletedNCT00914082
37Comparison of Dexamethasone Added to Ropivacaine and Ropivacaine Alone in Caudal Analgesia in Children Undergoing OrchiopexyCompletedNCT01604915
38Pain Management for Pectus Excavatum RepairCompletedNCT00413582
39Assessing Function in Pediatric Patients With Sickle Cell DiseaseCompletedNCT00590148
40Effectiveness of New Analgesic Strategy Compared to the Usal Antalgic StrategyCompletedNCT00874172
41Prediction and Characterization of Acute and Chronic Postoperative PainCompletedNCT01308385
42The Caudal Space in Children: Ultrasound EvaluationCompletedNCT01896076
43Subcapsular Orchiectomy in Men With Klinefelter SyndromeCompletedNCT01750632
44Early Labour Assessment and Support at HomeCompletedNCT00225329
45Painful Channelopathies StudyRecruitingNCT02696746
46A Comprehensive Care Plan for Pediatric Patients With Vaso-Occlusive CrisesRecruitingNCT02698761
47Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain CrisesRecruitingNCT02573714
48A Randomised Trial Comparing Supraclavicular Block vs Supraclavicular and Pecs II Block in Arteriovenous GraftingRecruitingNCT02331030
49Nuss Procedure: Clinical Options in Pediatric Pain Management?Active, not recruitingNCT02009267
50Comparing Pedicle Screw Systems for the Treatment of Adolescent Paediatric Spine DeformityNot yet recruitingNCT02590380

Search NIH Clinical Center for Neuropathy, Hereditary Sensory and Autonomic, Type V


Cochrane evidence based reviews: pain insensitivity, congenital

Genetic Tests for Neuropathy, Hereditary Sensory and Autonomic, Type V

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Genetic tests related to Neuropathy, Hereditary Sensory and Autonomic, Type V:

id Genetic test Affiliating Genes
1 Indifference to Pain, Congenital, Autosomal Recessive27
2 Congenital Sensory Neuropathy with Selective Loss of Small Myelinated Fibers27
3 Congenital Indifference to Pain, Autosomal Recessive24 SCN9A
4 Hereditary Sensory and Autonomic Neuropathy Type V24 NGF

Anatomical Context for Neuropathy, Hereditary Sensory and Autonomic, Type V

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MalaCards organs/tissues related to Neuropathy, Hereditary Sensory and Autonomic, Type V:

36
Tongue, Bone, Spinal cord, Brain, Liver, Heart

Publications for Neuropathy, Hereditary Sensory and Autonomic, Type V

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Variations for Neuropathy, Hereditary Sensory and Autonomic, Type V

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UniProtKB/Swiss-Prot genetic disease variations for Neuropathy, Hereditary Sensory and Autonomic, Type V:

70
id Symbol AA change Variation ID SNP ID
1NGFp.Arg221TrpVAR_030659rs11466112
2SCN9Ap.Arg907GlnVAR_064610

Clinvar genetic disease variations for Neuropathy, Hereditary Sensory and Autonomic, Type V:

5 (show all 11)
id Gene Variation Type Significance SNP ID Assembly Location
1NGFNM_002506.2(NGF): c.661C> T (p.Arg221Trp)SNVPathogenicrs11466112GRCh37Chr 1, 115828756: 115828756
2SCN9ANM_002977.3(SCN9A): c.554G> A (p.Arg185His)SNVPathogenicrs73969684GRCh38Chr 2, 166305834: 166305834
3SCN9ANM_002977.3(SCN9A): c.3993delGinsTT (p.Leu1331Phefs)indelPathogenicrs606231279GRCh37Chr 2, 167085381: 167085381
4SCN9ANM_002977.3(SCN9A): c.2690G> A (p.Trp897Ter)SNVPathogenicrs794729216GRCh37Chr 2, 167133644: 167133644
5NGFNGF, 680C-A AND 2-BP DEL, 681GGdeletionPathogenicChr na, -1: -1
6SCN9ANM_002977.3(SCN9A): c.1376C> G (p.Ser459Ter)SNVPathogenicrs121908908GRCh37Chr 2, 167143072: 167143072
7SCN9ASCN9A, 1-BP DEL, 2298TdeletionPathogenicChr na, -1: -1
8SCN9ANM_002977.3(SCN9A): c.2691G> A (p.Trp897Ter)SNVPathogenicrs121908909GRCh37Chr 2, 167133643: 167133643
9SCN9ANM_002977.3(SCN9A): c.829C> T (p.Arg277Ter)SNVPathogenicrs121908916GRCh37Chr 2, 167159672: 167159672
10SCN9ANM_002977.3(SCN9A): c.984C> A (p.Tyr328Ter)SNVPathogenicrs121908917GRCh37Chr 2, 167149864: 167149864
11SCN9ANM_002977.3(SCN9A): c.29A> G (p.Gln10Arg)SNVPathogenicrs267607030GRCh37Chr 2, 167168238: 167168238

Expression for genes affiliated with Neuropathy, Hereditary Sensory and Autonomic, Type V

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Search GEO for disease gene expression data for Neuropathy, Hereditary Sensory and Autonomic, Type V.

Pathways for genes affiliated with Neuropathy, Hereditary Sensory and Autonomic, Type V

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GO Terms for genes affiliated with Neuropathy, Hereditary Sensory and Autonomic, Type V

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Cellular components related to Neuropathy, Hereditary Sensory and Autonomic, Type V according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Elongator holoenzyme complexGO:003358810.5ELP3, IKBKAP
2histone acetyltransferase complexGO:000012310.2ELP3, IKBKAP
3endosomeGO:000576810.0NGF, NGFR, NTRK1, NTRK2
4voltage-gated sodium channel complexGO:00015189.9SCN10A, SCN11A, SCN9A
5serine C-palmitoyltransferase complexGO:00170599.6SPTLC1, SPTLC2, SPTLC3, SPTSSA

Biological processes related to Neuropathy, Hereditary Sensory and Autonomic, Type V according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Ras protein signal transductionGO:004657910.8NGF, NTRK1
2mechanoreceptor differentiationGO:004249010.8NTRK1, NTRK2
3positive regulation of lipophagyGO:190450410.8SPTLC1, SPTLC2
4membrane depolarization during action potentialGO:008601010.6SCN10A, SCN11A, SCN9A
5regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:004328110.6NGF, NGFR
6neuronal action potentialGO:001922810.6SCN10A, SCN11A, SCN9A
7sphinganine biosynthetic processGO:004651110.6SPTLC1, SPTLC2
8regulation of ion transmembrane transportGO:003476510.6SCN10A, SCN11A, SCN9A
9regulation of postsynaptic membrane potentialGO:006007810.6SCN10A, SCN11A, SCN9A
10sodium ion transmembrane transportGO:003572510.5SCN10A, SCN11A, SCN9A
11neurotrophin TRK receptor signaling pathwayGO:004801110.5NGF, NGFR, NTRK1
12sodium ion transportGO:000681410.4SCN10A, SCN11A, SCN9A
13sphingomyelin biosynthetic processGO:000668610.4SPTLC1, SPTLC2
14positive regulation of axonogenesisGO:005077210.4NGF, NGFR, NTRK2
15positive regulation of synaptic transmission, glutamatergicGO:005196810.4NGFR, NTRK1, NTRK2
16ceramide biosynthetic processGO:004651310.3SPTLC1, SPTLC2, SPTSSA
17sphingosine biosynthetic processGO:004651210.3SPTLC1, SPTLC2
18negative regulation of neuron apoptotic processGO:004352410.0FAM134B, NGF, NGFR, NTRK1, NTRK2
19sensory perception of painGO:001923310.0FAM134B, NGFR, NTRK1, SCN10A, SCN9A
20tRNA wobble uridine modificationGO:00020989.9ELP3, IKBKAP
21sphingolipid biosynthetic processGO:00301489.7SPTLC1, SPTLC2, SPTLC3, SPTSSA

Molecular functions related to Neuropathy, Hereditary Sensory and Autonomic, Type V according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1neurotrophin bindingGO:004312110.6NTRK1, NTRK2
2nerve growth factor bindingGO:004840610.5NGFR, NTRK1
3phosphorylase kinase regulator activityGO:000860710.4ELP3, IKBKAP
4pyridoxal phosphate bindingGO:003017010.2SPTLC1, SPTLC2, SPTLC3
5H4 histone acetyltransferase activityGO:001048510.2ELP3, NAA50
6RNA polymerase II core bindingGO:000099310.2ELP3, IKBKAP
7voltage-gated sodium channel activityGO:00052489.9SCN10A, SCN11A, SCN9A
8serine C-palmitoyltransferase activityGO:00047589.7SPTLC1, SPTLC2, SPTLC3, SPTSSA

Sources for Neuropathy, Hereditary Sensory and Autonomic, Type V

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet