MCID: NRR001
MIFTS: 48

Neuroretinitis malady

Neuronal category

Summaries for Neuroretinitis

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33MalaCards
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MalaCards: Neuroretinitis, also known as focal retinitis and retinochoroiditis, juxtapapillary, is related to vasculitis and nephritis. An important gene associated with Neuroretinitis is GORAB (golgin, RAB6-interacting), and among its related pathways are Spinal Cord Injury and A-beta Uptake & Degradation. The compounds triamcinolone acetonide and anaphylatoxin have been mentioned in the context of this disorder. Affiliated tissues include brain and retina, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Aliases & Classifications for Neuroretinitis

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

neuroretinitis 8 61
focal retinitis and retinochoroiditis, juxtapapillary 8
juxtapapillary focal retinitis and retinochoroiditis 8
papilloretinitis 8


External Ids:

Disease Ontology8 DOID:10176
ICD9CM27 363.05
SNOMED-CT57 46497009, 410471004
MeSH35 D012173

Related Diseases for Neuroretinitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Neuroretinitis:



Diseases related to neuroretinitis

Clinical Features for Neuroretinitis

Drugs & Therapeutics for Neuroretinitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Neuroretinitis

Drug clinical trials:

Search ClinicalTrials for Neuroretinitis

Search NIH Clinical Center for Neuroretinitis

Search CenterWatch for Neuroretinitis

Genetic Tests for Neuroretinitis

Anatomical Context for Neuroretinitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Neuroretinitis:

33
Brain, Retina

Animal Models for Neuroretinitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Neuroretinitis

Sources:
51PubMed
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Articles related to Neuroretinitis:

(show top 50)    (show all 222)
idTitleAuthorsYear
1
Central scotoma without prodromal illness caused by Bartonella henselae neuroretinitis. (23481153)
2013
2
Letter to the editor. Diffuse unilateral subacute neuroretinitis (DUSN). (22216955)
2012
3
Rapid regression of exudative maculopathy in idiopathic retinitis, vasculitis, aneurysms and neuroretinitis syndrome after intravitreal ranibizumab. (22949913)
2012
4
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis in a patient with antiphospholipid syndrome. (22332229)
2012
5
A case of bilateral Chikungunya neuroretinitis. (21881835)
2012
6
Imaging in the diagnosis and management of diffuse unilateral subacute neuroretinitis. (22954952)
2012
7
Photoreceptor recovery following laser photocoagulation and albendazole in diffuse unilateral subacute neuroretinitis. (21555627)
2011
8
Neuroretinitis as an initial presentation of lupus-like illness with antiphospholipid syndrome. (20702528)
2010
9
Intravitreal Bevacizumab for Macular Edema from Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis. (20337264)
2010
10
Disseminated bartonellosis presenting as neuroretinitis in a young adult with human immunodeficiency virus infection. (20216243)
2010
11
Diffuse unilateral subacute neuroretinitis masquerading as a white-dot syndrome. (19395629)
2009
12
A case of bilateral presumed chikungunya neuroretinitis. (19237792)
2009
13
Clinical evolution of neuroretinitis in Parry-Romberg syndrome. (18404964)
2008
14
Progressive retinal dysfunction in diffuse unilateral subacute neuroretinitis. (16714269)
2006
15
Indocyanine green angiography in diffuse unilateral subacute neuroretinitis. (16284602)
2006
16
Diffuse unilateral subacute neuroretinitis with unusual findings. (17056380)
2006
17
A case of idiopathic retinal vasculitis, aneurysm, and neuroretinitis effectively treated by steroid pulse therapy. (16604399)
2006
18
Clinical features and outcomes of patients with diffuse unilateral subacute neuroretinitis treated with oral albendazole. (16026752)
2005
19
Recurrent neuroretinitis in an adolescent with ulcerative colitis. (16340494)
2005
20
Pattern visual evoked potentials in eyes with disc swelling due to cat scratch disease-associated neuroretinitis. (16328936)
2005
21
An atypical case of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome. (15184951)
2005
22
Simultaneous occurrence of neuroretinitis and optic perineuritis in a single eye. (12616085)
2003
23
Neuroretinitis associated with cat-scratch disease in Japanese patients. (14641271)
2003
24
A case of cat scratch disease neuroretinitis confirmed by polymerase chain reaction. (12842212)
2003
25
Bilateral neuroretinitis in a 6-year-old boy with acquired toxoplasmosis. (14557195)
2003
26
Chickenpox neuroretinitis in a 9 year old child. (11914224)
2002
27
Nematode infections of the eye: toxocariasis, onchocerciasis, diffuse unilateral subacute neuroretinitis, and cysticercosis. (12434484)
2002
28
Leber's idiopathic stellate neuroretinitis: letter to editor. (11960168)
2002
29
Pars plana vitrectomy for epiretinal membrane secondary to cat scratch neuroretinitis. (11421023)
2001
30
Bartonella henselae neuroretinitis in cat scratch disease. (11587306)
2001
31
Leber's idiopathic stellate neuroretinitis. (11714123)
2001
32
Reports of diffuse unilateral subacute neuroretinitis. (11074824)
2000
33
Indocyanine green angiography in a case of idiopathic retinal vasculitis, aneurysms and neuroretinitis. (11040917)
2000
34
Tuberculous neuroretinitis. (10494950)
1999
35
Diffuse unilateral subacute neuroretinitis in Europe. (10230594)
1999
36
Cat-scratch neuroretinitis. (10506816)
1999
37
Neuroretinitis and encephalopathy due to Bartonella henselae infection. (9448896)
1997
38
Hypertensive retinopathy mimicking neuroretinitis in a twelve-year-old girl. (9220570)
1997
39
Optic neuroretinitis, a rare manifestation of herpes zoster ophthalmicus: a case report. (9282530)
1997
40
Neuroretinitis in cat scratch disease associated with macular star. (9150670)
1997
41
Presumed ocular larva migrans presenting with features of diffuse unilateral subacute neuroretinitis. (8562554)
1995
42
Neuroretinitis in cat-scratch disease associated with the macular star. (7528909)
1994
43
Diffuse unilateral subacute neuroretinitis. Morphometric, serologic, and epidemiologic support for Baylisascaris as a causative agent. (8233397)
1993
44
Neuroretinitis: an unusual presentation of ocular toxoplasmosis. (1562128)
1992
45
Leber's idiopathic stellate neuroretinitis. (2029114)
1991
46
Does neuroretinitis rule out multiple sclerosis? (3632377)
1987
47
Syphilitic neuroretinitis. (6837690)
1983
48
Healed luetic neuroretinitis papulosa. (15406717)
1949
49
Retinitis Pigmentosa Associated with Albuminuric Neuroretinitis. (16692246)
1911
50
The Channel by which, in Cases of Neuroretinitis, the Exudation proceeds from the Brain into the Eye. (16691681)
1870

Genetic Variations for Neuroretinitis

Expression for genes affiliated with Neuroretinitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Neuroretinitis

Search GEO for disease gene expression data for Neuroretinitis.

Pathways for genes affiliated with Neuroretinitis

Sources:
38NCBI BioSystems Database, 53R&D Systems, 52QIAGEN, 4Cell Signaling Technology, 30KEGG, 12EMD Millipore, 54Reactome
See all sources

Pathways related to Neuroretinitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CCL2, CCR2
29.3CX3CR1, CCL2, CCR2
3
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9.3IL10RA, CCL2, CCL5
4
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9.2CCL2, CCR5, CCL5
59.1IFNG, CCL2, CCR2
68.7CCL5, CCR2, CXCL12, IL10
7
Hide members
8.6CCR2, CCR5, CX3CR1, CXCL12, IL10RA
8
Hide members
8.6IL10, IL10RA, IFNG, CCR5
9
Hide members
8.6IFNG, CXCL12, IL10RA, IL10
10
Development PDGF signaling via STATs and NF-kB
Hide members
8.5CCL2, IFNG, IL10RA, IL10
11
Hide members
8.4CCL5, CCL2, IFNG, IL10
12
Hide members
8.4CCL5, CCR2, CCR5, CCL2, CXCL12
13
Hide members
8.4SERPINF1, IL10RA, CXCL12, CX3CR1, CCR5, CCR2
14
Hide members
8.3IL10RA, CXCL12, CX3CR1, CCR5, CCR2, CCL5
158.0CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
16
Hide members
8.0CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
17
Hide members
8.0CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
18
Hide members
7.1CXCL12, CX3CR1, CCL2, CCR5, CCR2, CCL5

Compounds for genes affiliated with Neuroretinitis

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 2BitterDB, 24HMDB
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Compounds related to Neuroretinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1triamcinolone acetonide45 2911.6SERPINF1
2anaphylatoxin4510.4CCL5
3glutamate4510.1CLN3, CS
4tak-7792910.1CCR5, CCR2
5mcp 24510.0CCR5, CCL5
6ccl22910.0CCR2, CCR5
7rantes459.9CXCL12, IFNG
8ccl8299.9CCR2, CCR5
9ccl11299.9CCR2, CCR5
10ccl16299.8CCR2, CCR5
11bicyclam459.7CCR5, CXCL12
12cyclosporin a45 29 6011.7CCL5, IFNG, CS
13cerivastatin45 50 29 1112.5ABCB1, CCL5
14cyclophosphamide45 50 1111.5ABCB1, CXCL12
15shikonin459.5CCR5, CCL2, CXCL12
16gm-csf45 2910.4CCL5, IFNG, IL10
17mcp 1459.4IL10, CCL2, CCL5
18glatiramer acetate45 1110.4CCL5, IFNG, IL10
19triptolide459.3CCL5, CCL2, IFNG
20il-12459.2IL10, IFNG, CCL2
21sdf 1459.2CXCL12, CCL2, CCR5, CCL5
22polymyxin b459.1CCL2, IFNG, IL10
23larc459.1CCL5, CCR5, CCL2, CXCL12
24pertussis459.1CCL5, CCL2, CXCL12
25cytochalasin d45 6010.1CCL5, CCR5, CCL2, CXCL12
26mip 1alpha459.0IL10, CCL2, CCR5, CCL5
27tacrolimus45 50 1111.0CCL5, IFNG, ABCB1
28ccl445 299.8CCL5, CCR5, CCL2, CX3CR1, CXCL12
29indinavir45 50 1110.8CCL5, CCR5, IFNG, ABCB1
30serine458.7CCL5, CCR5, CCL2, CS, CLN3, SERPINF1
31dexamethasone45 50 29 1111.7CCL5, CS, CXCL12, ABCB1, SERPINF1
32ritonavir45 50 1110.6CCL5, CCR5, ABCB1
33quinine45 29 2 1111.6CCR5, CXCL12, IL10, ABCB1
34mdms458.5CCL5, CCR5, CCL2, CXCL12, IL10
35groalpha458.5CCL5, CCR5, CCL2, CXCL12, IL10
36mycophenolate mofetil45 50 1110.4IFNG, IL10, ABCB1
37histamine45 29 2410.4CCL5, CCR5, CCL2, IFNG, IL10
38sb 20358045 609.4CCL5, CCL2, IFNG, CXCL12, IL10
39arginine458.3CXCL12, CLN3, CS, IFNG, CCL2, CCR5
40il 10458.2CCL5, CCR5, CCL2, IFNG, IL10RA, IL10
41nitric oxide45 11 2410.2CCL5, CCL2, IFNG, CS, IL10, SERPINF1
425fluorouracil458.2ABCB1, CXCL12, IFNG, CCL2
43genistein45 29 60 2 11 2413.1ABCB1, CXCL12, IFNG, CCL2, CCL5
44actinomycin d458.1CCR5, CCL2, IFNG, CXCL12, ABCB1
45tarc458.0CCL5, CCR5, CCL2, IFNG, CXCL12, IL10
46cholesterol45 29 11 2411.0CCL5, CCR5, CCL2, CS, CXCL12, ABCB1
47zidovudine45 118.8CCR5, CCL2, CS, CXCL12, IL10, ABCB1
48vegf457.8CCL5, CCL2, IFNG, CX3CR1, CXCL12, IL10
49ccl345 298.7IL10, CCL5, CCR5, CCL2, IFNG, CX3CR1
50simvastatin45 50 60 29 11 2412.6CCL5, CCR5, CCL2, IFNG, IL10, ABCB1

GO Terms for genes affiliated with Neuroretinitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Neuroretinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.7SERPINF1, IL10, CXCL12, IFNG, CCL2, CCL5

Biological processes related to Neuroretinitis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell chemotaxisGO:01082010.0CCR2, CCL5
2positive regulation of immune complex clearance by monocytes and macrophagesGO:0902659.9CCL2, CCR2
3regulation of vascular endothelial growth factor productionGO:0105749.9CCR2, CCL2
4positive regulation of macrophage chemotaxisGO:0107599.8CCL2, CCL5
5cellular homeostasisGO:0197259.7CCL2, CCR2
6dendritic cell chemotaxisGO:0024079.7CCL5, CCR2, CCR5
7cellular defense responseGO:0069689.7CX3CR1, CCR5, CCR2
8positive regulation of monocyte chemotaxisGO:0900269.7CXCL12, CCR2, CCL5
9cellular response to fibroblast growth factor stimulusGO:0443449.6CCL2, CCL5
10macrophage chemotaxisGO:0482469.6CX3CR1, CCL2, CCL5
11positive regulation of MHC class II biosynthetic processGO:0453489.6IL10, IFNG
12positive regulation of T cell activationGO:0508709.5CCL2, CCR2
13MAPK cascadeGO:0001659.4CCL5, CCR5, CCL2
14negative regulation of angiogenesisGO:0165259.4CCR2, CCL2, CX3CR1, SERPINF1
15negative regulation of growth of symbiont in hostGO:0441309.3IL10, IFNG
16monocyte chemotaxisGO:0025489.3CCL2, CCL5
17response to virusGO:0096159.2CCL5, IFNG, CXCL12
18cellular calcium ion homeostasisGO:0068749.1CXCL12, CCL2, CCR2, CCL5
19G-protein coupled receptor signaling pathwayGO:0071868.9CCR5, CCL2, CX3CR1, CXCL12
20inflammatory responseGO:0069548.5CCL5, CCR2, CCR5, CCL2, IL10
21chemokine-mediated signaling pathwayGO:0700988.4CXCL12, CX3CR1, CCL2, CCR5, CCR2, CCL5
22cellular response to lipopolysaccharideGO:0712228.4CCR5, CCL2, IFNG, CX3CR1, IL10
23chemotaxisGO:0069358.4CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
24response to drugGO:0424938.2CCL2, IFNG, IL10, ABCB1

Molecular functions related to Neuroretinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:0164939.7CCR5, CCR2
2CCR2 chemokine receptor bindingGO:0317279.5CCL2, CCR2
3chemokine receptor activityGO:0049509.4CX3CR1, CCR5, CCR2
4chemokine activityGO:0080098.8CCL5, CCL2, CXCL12

Products for genes affiliated with Neuroretinitis

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  • Lysates
  • Antibodies

Sources for Neuroretinitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet