MCID: NRR001
MIFTS: 52

Neuroretinitis malady

Neuronal diseases category

Summaries for Neuroretinitis

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MalaCards: Neuroretinitis, also known as focal retinitis and retinochoroiditis, juxtapapillary, is related to vasculitis and glaucoma. An important gene associated with Neuroretinitis is GORAB (golgin, RAB6-interacting), and among its related pathways are Spinal Cord Injury and A-beta Uptake & Degradation. The compounds triamcinolone acetonide and anaphylatoxin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Aliases & Classifications for Neuroretinitis

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroretinitis 8 60
focal retinitis and retinochoroiditis, juxtapapillary 8
juxtapapillary focal retinitis and retinochoroiditis 8
papilloretinitis 8


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Disease Ontology8 DOID:10176
ICD9CM27 363.05
SNOMED-CT56 46497009, 410471004
MeSH34 D012173

Related Diseases for Neuroretinitis

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17GeneCards, 18GeneDecks
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Diseases related to Neuroretinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.9CCL2
2glaucoma30.4SERPINF1
3hypertension30.3CCL2
4retinal detachment30.1SERPINF1
5multiple sclerosis30.1CCL5, CCR2, CCR5, CCL2, IFNG, CX3CR1
6eye disease30.0CCL2
7uveitis30.0SERPINF1, IL10, IFNG, CCL2, CCR5
8neuritis29.8CCL5
9herpes simplex29.8CCL5
10hepatitis29.8CXCL12
11diabetic retinopathy29.8SERPINF1, CXCL12
12macular retinal edema29.8CXCL12, SERPINF1
13encephalitis29.7CCL2, CCR5, CCL5
14hepatitis c29.7CCR5, IFNG, IL10
15sarcoidosis29.7CCL5, CCR5, CCL2, IFNG
16leukemia29.7IFNG, CXCL12, ABCB1, SERPINF1
17retinitis10.7
18cat-scratch disease10.6
19retinal vasculitis10.6
20toxocariasis10.2
21toxoplasmosis10.2
22antiphospholipid syndrome10.1
23choroiditis10.1
24ocular hypertension10.1
25lyme disease10.1
26retinal artery occlusion10.1
27syphilis10.1
28branch retinal artery occlusion10.0
29cysticercosis10.0
30aseptic meningitis10.0
31chikungunya10.0
32mumps10.0
33hypertensive retinopathy10.0
34meningitis10.0
35hyperglycemia10.0SERPINF1
36spotted fever10.0CS
37bronchiolitis10.0CCL5
38chagas disease10.0CCR5
39polymyalgia rheumatica10.0CCL5
40rhinitis10.0CCL5
41age related macular degeneration10.0CX3CR1
42acute myocardial infarction10.0CCL5
43retinoblastoma10.0SERPINF1
44myopathy10.0CS
45wegener's granulomatosis10.0CCR5
46synovitis10.0CX3CR1
47guillain-barre syndrome10.0CCR5
48essential hypertension10.0CCR5
49ischemia10.0CXCL12
50pancreatic cancer10.0CXCL12

Graphical network of the top 20 diseases related to Neuroretinitis:



Diseases related to neuroretinitis

Clinical Features for Neuroretinitis

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Drugs & Therapeutics for Neuroretinitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Neuroretinitis

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Genetic Tests for Neuroretinitis

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Anatomical Context for Neuroretinitis

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32MalaCards
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MalaCards organs/tissues related to Neuroretinitis:

32
Eye, Retina, Testes, Brain

Animal Models for Neuroretinitis or affiliated genes

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36MGI
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Publications for Neuroretinitis

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50PubMed
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Articles related to Neuroretinitis:

(show top 50)    (show all 240)
idTitleAuthorsYear
1
Atypical cat scratch disease with vitritis, serous macular detachment, neuroretinitis, and retrobulbar optic neuritis. (22366917)
2013
2
Enhanced detection of open-angle glaucoma with an anatomically accurate optical coherence tomography-derived neuroretinal rim parameter. (23265804)
2013
3
Molecular diagnosis and ocular imaging of West Nile virus retinitis and neuroretinitis. (23642374)
2013
4
Evaluation of hepatitis C virus as a risk factor for HIV-associated neuroretinal disorder. (24081683)
2013
5
Diffuse unilateral subacute neuroretinitis. (23244243)
2013
6
Letter to the editor. Diffuse unilateral subacute neuroretinitis (DUSN). (22216955)
2012
7
Imaging in the diagnosis and management of diffuse unilateral subacute neuroretinitis. (22954952)
2012
8
Photoreceptor recovery following laser photocoagulation and albendazole in diffuse unilateral subacute neuroretinitis. (21555627)
2011
9
Ocular parasitic diseases: a review on toxocariasis and diffuse unilateral subacute neuroretinitis. (20669882)
2011
10
Idiopathic retinal vasculitis, aneurysms and neuroretinitis syndrome associated with positive perinuclear antineutrophil cytoplasmic antibody. (22454754)
2011
11
Intraocular nematode with diffuse unilateral subacute neuroretinitis: case report. (21679403)
2011
12
Spontaneous branch artery occlusion in idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis syndrome despite panretinal laser photocoagulation of widespread retina nonperfusion. (20716325)
2011
13
Infrared imaging of choroidal involvement in Leber's idiopathic stellate neuroretinitis. (21792291)
2011
14
Neuroretinitis as an initial presentation of lupus-like illness with antiphospholipid syndrome. (20702528)
2010
15
Intravitreal bevacizumab (Avastin) in idiopathic retinitis, vasculitis, aneurysms and neuroretinitis. (19508455)
2010
16
Neuroretinitis Caused by Bartonella henselae (Cat-Scratch Disease) in a 13-Year-Old Girl. (20628521)
2010
17
Diffuse unilateral subacute neuroretinitis masquerading as a white-dot syndrome. (19395629)
2009
18
Optic coherence tomography in a patient with diffuse unilateral subacute neuroretinitis. (19466326)
2009
19
A serologically proven case of cat-scratch disease presenting with neuroretinitis. (19801700)
2009
20
Utility of MR imaging in cat-scratch neuroretinitis. (17583805)
2007
21
Unilateral neuroretinitis associated with nasal cilioretinal artery occlusion. (17410967)
2007
22
Bilateral neuroretinitis with peripapillary serous retinal detachments in a patient with HIV and HBV. (16219743)
2005
23
Recurrent neuroretinitis in an adolescent with ulcerative colitis. (16340494)
2005
24
Diffuse unilateral subacute neuroretinitis in Venezuela. (16242189)
2005
25
Tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) with unilateral neuroretinitis: a case report. (15309980)
2004
26
Profound infantile neuroretinal dysfunction in a heterozygote for the CLN3 genetic defect. (15032383)
2004
27
Neuroretinitis associated with cat-scratch disease in Japanese patients. (14641271)
2003
28
Idiopathic recurrent neuroretinitis: effects of long-term immunosuppression. (12523886)
2003
29
Nematode infections of the eye: toxocariasis, onchocerciasis, diffuse unilateral subacute neuroretinitis, and cysticercosis. (12434484)
2002
30
Macular star in neuroretinitis. (11405817)
2001
31
Nematode infections of the eye: toxocariasis and diffuse unilateral subacute neuroretinitis. (11734685)
2001
32
Indocyanine green angiography in a case of idiopathic retinal vasculitis, aneurysms and neuroretinitis. (11040917)
2000
33
Hypopyon in a patient with presumptive diffuse unilateral subacute neuroretinitis. (10980685)
2000
34
Management of B. henselae neuroretinitis in cat-scratch disease. (9917766)
1999
35
The first South American case of diffuse unilateral subacute neuroretinitis caused by a large nematode. (10532461)
1999
36
Neuroretinitis and encephalopathy due to Bartonella henselae infection. (9448896)
1997
37
Optic neuroretinitis, a rare manifestation of herpes zoster ophthalmicus: a case report. (9282530)
1997
38
Cat-scratch disease diagnosed serologically using an enzyme immunoassay in a patient with neuroretinitis. (8602794)
1996
39
Neuroretinitis: an unusual presentation of ocular toxoplasmosis. (1562128)
1992
40
Diffuse unilateral subacute neuroretinitis in South America. (1520112)
1992
41
Neuroretinitis in childhood. (1588477)
1992
42
Peripapillary angiomatosis associated with cat-scratch neuroretinitis. (1543446)
1992
43
Neuroretinitis in cat scratch disease. (2141865)
1990
44
Does neuroretinitis rule out multiple sclerosis? (2705892)
1989
45
Does neuroretinitis rule out multiple sclerosis? (3632377)
1987
46
Diffuse unilateral subacute neuroretinitis syndrome: probable cause. (6540077)
1984
47
Acute herpetic thrombotic retinal angiitis and necrotizing neuroretinitis ("acute retinal necrosis syndrome"). (6312644)
1983
48
Further observations concerning the diffuse unilateral subacute neuroretinitis syndrome. (6639421)
1983
49
Retinal arterial obstruction in association with presumed Toxocara canis neuroretinitis. (7337346)
1981
50
Bilateral acute neuroretinitis with sarcoidosis treated with corticotropin and cortisone. (13079380)
1953

Genetic Variations for Neuroretinitis

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Expression for genes affiliated with Neuroretinitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroretinitis

Search GEO for disease gene expression data for Neuroretinitis.

Pathways for genes affiliated with Neuroretinitis

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Sources:
37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Neuroretinitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CCL2, CCR2
29.3CX3CR1, CCL2, CCR2
3
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9.3IL10RA, CCL2, CCL5
4
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9.2CCL2, CCR5, CCL5
59.1IFNG, CCL2, CCR2
68.7CCL5, CCR2, CXCL12, IL10
7
Hide members
8.6CCR2, CCR5, CX3CR1, CXCL12, IL10RA
8
Hide members
8.6IL10, IL10RA, IFNG, CCR5
9
Hide members
8.6IFNG, CXCL12, IL10RA, IL10
10
Development PDGF signaling via STATs and NF-kB
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8.5CCL2, IFNG, IL10RA, IL10
11
Hide members
8.4CCL5, CCL2, IFNG, IL10
12
Hide members
8.4CCL5, CCR2, CCR5, CCL2, CXCL12
13
Hide members
8.4SERPINF1, IL10RA, CXCL12, CX3CR1, CCR5, CCR2
14
Hide members
8.3IL10RA, CXCL12, CX3CR1, CCR5, CCR2, CCL5
158.0CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
16
Hide members
8.0CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
17
Hide members
8.0CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
18
Hide members
7.1CXCL12, CX3CR1, CCL2, CCR5, CCR2, CCL5

Compounds for genes affiliated with Neuroretinitis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 2BitterDB, 24HMDB
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Compounds related to Neuroretinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1triamcinolone acetonide44 2811.6SERPINF1
2anaphylatoxin4410.4CCL5
3glutamate4410.1CLN3, CS
4tak-7792810.1CCR5, CCR2
5mcp 24410.0CCR5, CCL5
6ccl22810.0CCR2, CCR5
7rantes449.9CXCL12, IFNG
8ccl8289.9CCR2, CCR5
9ccl11289.9CCR2, CCR5
10ccl16289.8CCR2, CCR5
11bicyclam449.7CCR5, CXCL12
12cyclosporin a44 28 5911.7CCL5, IFNG, CS
13cerivastatin44 49 28 1112.5ABCB1, CCL5
14cyclophosphamide44 49 1111.5ABCB1, CXCL12
15shikonin449.5CCR5, CCL2, CXCL12
16gm-csf44 2810.4CCL5, IFNG, IL10
17mcp 1449.4IL10, CCL2, CCL5
18glatiramer acetate44 1110.4CCL5, IFNG, IL10
19triptolide449.3CCL5, CCL2, IFNG
20il-12449.2IL10, IFNG, CCL2
21sdf 1449.2CXCL12, CCL2, CCR5, CCL5
22polymyxin b449.1CCL2, IFNG, IL10
23larc449.1CCL5, CCR5, CCL2, CXCL12
24pertussis449.1CCL5, CCL2, CXCL12
25cytochalasin d44 5910.1CCL5, CCR5, CCL2, CXCL12
26mip 1alpha449.0IL10, CCL2, CCR5, CCL5
27tacrolimus44 49 1111.0CCL5, IFNG, ABCB1
28ccl444 289.8CCL5, CCR5, CCL2, CX3CR1, CXCL12
29indinavir44 49 1110.8CCL5, CCR5, IFNG, ABCB1
30serine448.7CCL5, CCR5, CCL2, CS, CLN3, SERPINF1
31dexamethasone44 49 28 1111.7CCL5, CS, CXCL12, ABCB1, SERPINF1
32ritonavir44 49 1110.6CCL5, CCR5, ABCB1
33quinine44 28 2 1111.6CCR5, CXCL12, IL10, ABCB1
34mdms448.5CCL5, CCR5, CCL2, CXCL12, IL10
35groalpha448.5CCL5, CCR5, CCL2, CXCL12, IL10
36mycophenolate mofetil44 49 1110.4IFNG, IL10, ABCB1
37histamine44 28 2410.4CCL5, CCR5, CCL2, IFNG, IL10
38sb 20358044 599.4CCL5, CCL2, IFNG, CXCL12, IL10
39arginine448.3CXCL12, CLN3, CS, IFNG, CCL2, CCR5
40il 10448.2CCL5, CCR5, CCL2, IFNG, IL10RA, IL10
41nitric oxide44 11 2410.2CCL5, CCL2, IFNG, CS, IL10, SERPINF1
425fluorouracil448.2ABCB1, CXCL12, IFNG, CCL2
43genistein44 28 59 2 11 2413.1ABCB1, CXCL12, IFNG, CCL2, CCL5
44actinomycin d448.1CCR5, CCL2, IFNG, CXCL12, ABCB1
45tarc448.0CCL5, CCR5, CCL2, IFNG, CXCL12, IL10
46cholesterol44 28 11 2411.0CCL5, CCR5, CCL2, CS, CXCL12, ABCB1
47zidovudine44 118.8CCR5, CCL2, CS, CXCL12, IL10, ABCB1
48vegf447.8CCL5, CCL2, IFNG, CX3CR1, CXCL12, IL10
49ccl344 288.7IL10, CCL5, CCR5, CCL2, IFNG, CX3CR1
50simvastatin44 49 59 28 11 2412.6CCL5, CCR5, CCL2, IFNG, IL10, ABCB1

GO Terms for genes affiliated with Neuroretinitis

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16Gene Ontology
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Cellular components related to Neuroretinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.7SERPINF1, IL10, CXCL12, IFNG, CCL2, CCL5

Biological processes related to Neuroretinitis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell chemotaxisGO:01082010.0CCR2, CCL5
2positive regulation of immune complex clearance by monocytes and macrophagesGO:0902659.9CCL2, CCR2
3regulation of vascular endothelial growth factor productionGO:0105749.9CCR2, CCL2
4positive regulation of macrophage chemotaxisGO:0107599.8CCL2, CCL5
5cellular homeostasisGO:0197259.7CCL2, CCR2
6dendritic cell chemotaxisGO:0024079.7CCL5, CCR2, CCR5
7cellular defense responseGO:0069689.7CX3CR1, CCR5, CCR2
8positive regulation of monocyte chemotaxisGO:0900269.7CXCL12, CCR2, CCL5
9cellular response to fibroblast growth factor stimulusGO:0443449.6CCL2, CCL5
10macrophage chemotaxisGO:0482469.6CX3CR1, CCL2, CCL5
11positive regulation of MHC class II biosynthetic processGO:0453489.6IL10, IFNG
12positive regulation of T cell activationGO:0508709.5CCL2, CCR2
13MAPK cascadeGO:0001659.4CCL5, CCR5, CCL2
14negative regulation of angiogenesisGO:0165259.4CCR2, CCL2, CX3CR1, SERPINF1
15negative regulation of growth of symbiont in hostGO:0441309.3IL10, IFNG
16monocyte chemotaxisGO:0025489.3CCL2, CCL5
17response to virusGO:0096159.2CCL5, IFNG, CXCL12
18cellular calcium ion homeostasisGO:0068749.1CXCL12, CCL2, CCR2, CCL5
19G-protein coupled receptor signaling pathwayGO:0071868.9CCR5, CCL2, CX3CR1, CXCL12
20inflammatory responseGO:0069548.5CCL5, CCR2, CCR5, CCL2, IL10
21chemokine-mediated signaling pathwayGO:0700988.4CXCL12, CX3CR1, CCL2, CCR5, CCR2, CCL5
22cellular response to lipopolysaccharideGO:0712228.4CCR5, CCL2, IFNG, CX3CR1, IL10
23chemotaxisGO:0069358.4CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
24response to drugGO:0424938.2CCL2, IFNG, IL10, ABCB1

Molecular functions related to Neuroretinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:0164939.7CCR5, CCR2
2CCR2 chemokine receptor bindingGO:0317279.5CCL2, CCR2
3chemokine receptor activityGO:0049509.4CX3CR1, CCR5, CCR2
4chemokine activityGO:0080098.8CCL5, CCL2, CXCL12

Products for genes affiliated with Neuroretinitis

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Sources for Neuroretinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet