MCID: NRR001
MIFTS: 52

Neuroretinitis malady

Neuronal diseases category

Summaries for Neuroretinitis

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MalaCards: Neuroretinitis, also known as focal retinitis and retinochoroiditis, juxtapapillary, is related to vasculitis and glaucoma. An important gene associated with Neuroretinitis is GORAB (golgin, RAB6-interacting), and among its related pathways are Spinal Cord Injury and A-beta Uptake & Degradation. The compounds triamcinolone acetonide and anaphylatoxin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Aliases & Classifications for Neuroretinitis

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroretinitis 8 60
focal retinitis and retinochoroiditis, juxtapapillary 8
juxtapapillary focal retinitis and retinochoroiditis 8
papilloretinitis 8


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Disease Ontology8 DOID:10176
ICD9CM27 363.05
SNOMED-CT56 46497009, 410471004
MeSH34 D012173

Related Diseases for Neuroretinitis

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17GeneCards, 18GeneDecks
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Diseases related to Neuroretinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.9CCL2
2glaucoma30.4SERPINF1
3hypertension30.3CCL2
4retinal detachment30.1SERPINF1
5multiple sclerosis30.1CCL5, CCR2, CCR5, CCL2, IFNG, CX3CR1
6eye disease30.0CCL2
7uveitis30.0SERPINF1, IL10, IFNG, CCL2, CCR5
8neuritis29.8CCL5
9herpes simplex29.8CCL5
10hepatitis29.8CXCL12
11diabetic retinopathy29.8SERPINF1, CXCL12
12macular retinal edema29.8CXCL12, SERPINF1
13encephalitis29.7CCL2, CCR5, CCL5
14hepatitis c29.7CCR5, IFNG, IL10
15sarcoidosis29.7CCL5, CCR5, CCL2, IFNG
16leukemia29.7IFNG, CXCL12, ABCB1, SERPINF1
17retinitis10.7
18cat-scratch disease10.6
19retinal vasculitis10.6
20toxocariasis10.2
21toxoplasmosis10.2
22antiphospholipid syndrome10.1
23choroiditis10.1
24ocular hypertension10.1
25lyme disease10.1
26retinal artery occlusion10.1
27syphilis10.1
28branch retinal artery occlusion10.0
29cysticercosis10.0
30aseptic meningitis10.0
31chikungunya10.0
32mumps10.0
33hypertensive retinopathy10.0
34meningitis10.0
35hyperglycemia10.0SERPINF1
36spotted fever10.0CS
37bronchiolitis10.0CCL5
38chagas disease10.0CCR5
39polymyalgia rheumatica10.0CCL5
40rhinitis10.0CCL5
41age related macular degeneration10.0CX3CR1
42acute myocardial infarction10.0CCL5
43retinoblastoma10.0SERPINF1
44myopathy10.0CS
45wegener's granulomatosis10.0CCR5
46synovitis10.0CX3CR1
47guillain-barre syndrome10.0CCR5
48essential hypertension10.0CCR5
49ischemia10.0CXCL12
50pancreatic cancer10.0CXCL12

Graphical network of the top 20 diseases related to Neuroretinitis:



Diseases related to neuroretinitis

Clinical Features for Neuroretinitis

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Drugs & Therapeutics for Neuroretinitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neuroretinitis

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Anatomical Context for Neuroretinitis

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32MalaCards
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MalaCards organs/tissues related to Neuroretinitis:

32
Eye, Retina, Brain, Testes

Animal Models for Neuroretinitis or affiliated genes

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36MGI
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Publications for Neuroretinitis

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50PubMed
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Articles related to Neuroretinitis:

(show top 50)    (show all 240)
idTitleAuthorsYear
1
Unilateral neuroretinitis secondary to Bartonella henselae infection. (24106074)
2014
2
Neuroretinitis with branch retinal artery occlusion in a 15-year-old female. (24348414)
2013
3
Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice. (22918646)
2012
4
Cat scratch neuroretinitis: the role of acute and convalescent titers for diagnosis. (21941214)
2012
5
Neuroretinitis caused by Bartonella quintana. (22926397)
2012
6
Lyme neuroretinitis in Singapore: a diagnostic dilemma. (22635283)
2012
7
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis in a patient with antiphospholipid syndrome. (22332229)
2012
8
A case of bilateral Chikungunya neuroretinitis. (21881835)
2012
9
Spectral domain optical coherence tomography in diffuse unilateral subacute neuroretinitis. (21860780)
2011
10
Neuroretinitis with retrobulbar involvement. (20613630)
2011
11
Neuroretinitis as a manifestation of Lyme disease in South India: a case report. (20370334)
2010
12
Usefulness of gallium scintigraphy patterns in a case of idiopathic retinal vasculitis, aneurysms and neuroretinitis. (19210328)
2010
13
Intraretinal worm documented by optical coherence tomography in a patient with diffuse unilateral subacute neuroretinitis: case report. (21225134)
2010
14
Bartonella henselae neuroretinitis in a 15-year-old girl with chronic myelogenous leukemia. (20006827)
2009
15
A case of bilateral presumed chikungunya neuroretinitis. (19237792)
2009
16
Neuroretinitis, a great mimicker. (19893649)
2008
17
Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes. (18985738)
2008
18
Macular hole following Bartonella henselae neuroretinitis. (18465733)
2008
19
Pre-macular nematode in diffuse unilateral subacute neuroretinitis. (18097459)
2008
20
Diffuse unilateral subacute neuroretinitis. (17634863)
2008
21
Intraocular pressure lowering, change of antiapoptotic molecule expression, and neuroretinal changes by dorzolamide 2%/timolol 0.5% combination in a chronic ocular hypertension rat model. (19049297)
2008
22
Progressive retinal dysfunction in diffuse unilateral subacute neuroretinitis. (16714269)
2006
23
Secondary unilateral glaucoma and neuroretinitis: atypical manifestation of cat-scratch disease. (16604397)
2006
24
Primary vascular occlusion in IRVAN (idiopathic retinal vasculitis, aneurysms, neuroretinitis) syndrome. (16766406)
2006
25
Late-stage diffuse unilateral subacute neuroretinitis: photocoagulation of the worm does not improve the visual acuity of affected patients. (16786179)
2005
26
Optical coherence tomography in a case of bilateral neuroretinitis. (15937438)
2005
27
Diffuse unilateral subacute neuroretinitis: report of a case from the Indian subcontinent and the importance of immediate photocoagulation. (17333480)
2005
28
Elevated intracranial pressure associated with idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome. (15348989)
2004
29
Optic disk melanocytoma with neuroretinitis. (15097902)
2004
30
Cat scratch disease (CSD) in patients with stellate neuroretinitis: 3 cases. (12564316)
2002
31
Prevalence of serologic evidence of cat scratch disease in patients with neuroretinitis. (10811077)
2000
32
Diffuse unilateral subacute neuroretinitis in China. (10815171)
2000
33
Diffuse unilateral subacute neuroretinitis in Europe. (10230594)
1999
34
Leber's neuroretinitis in a patient with serologic evidence of Bartonella elizabethae. (9654422)
1998
35
Neuroretinitis in cat scratch disease associated with macular star. (9150670)
1997
36
Subretinal migration of a nematode in a patient with diffuse unilateral subacute neuroretinitis. (8953990)
1996
37
Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella (Rochalimaea) henselae infection in immunocompetent patients and patients infected with human immunodeficiency virus type 1. (8562744)
1995
38
Diffuse unilateral subacute neuroretinitis syndrome in a German most likely caused by the raccoon roundworm, Baylisascaris procyonis. (8428681)
1993
39
Cat scratch disease associated with neuroretinitis in a 6-year-old girl. (1553216)
1992
40
Successful oral therapy for diffuse unilateral subacute neuroretinitis. (1808823)
1991
41
Diffuse unilateral subacute neuroretinitis. (1954217)
1991
42
Neuroretinitis in childhood. (2760791)
1989
43
Diffuse unilateral subacute neuroretinitis. (4014926)
1985
44
Leber's idiopathic stellate neuroretinitis. (6466174)
1984
45
Syphilitic neuroretinitis. (6837690)
1983
46
Diffuse unilateral subacute neuroretinitis. (564964)
1978
47
Neuroretinitis associated with herpes simplex encephalitis in an adult. (868948)
1977
48
Neuroretinitis following measles. (14354592)
1955
49
Allergic ocular reaction to the tuberculin test; bilateral cyclitis and neuroretinitis. (18119659)
1949
50
Healed luetic neuroretinitis papulosa. (15406717)
1949

Genetic Variations for Neuroretinitis

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Expression for genes affiliated with Neuroretinitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroretinitis

Search GEO for disease gene expression data for Neuroretinitis.

Pathways for genes affiliated with Neuroretinitis

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Sources:
37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Neuroretinitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CCL2, CCR2
29.3CX3CR1, CCL2, CCR2
3
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9.3IL10RA, CCL2, CCL5
4
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9.2CCL2, CCR5, CCL5
59.1IFNG, CCL2, CCR2
68.7CCL5, CCR2, CXCL12, IL10
7
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8.6CCR2, CCR5, CX3CR1, CXCL12, IL10RA
8
Hide members
8.6IL10, IL10RA, IFNG, CCR5
9
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8.6IFNG, CXCL12, IL10RA, IL10
10
Development PDGF signaling via STATs and NF-kB
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8.5CCL2, IFNG, IL10RA, IL10
11
Hide members
8.4CCL5, CCL2, IFNG, IL10
12
Hide members
8.4CCL5, CCR2, CCR5, CCL2, CXCL12
13
Hide members
8.4SERPINF1, IL10RA, CXCL12, CX3CR1, CCR5, CCR2
14
Hide members
8.3IL10RA, CXCL12, CX3CR1, CCR5, CCR2, CCL5
158.0CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
16
Hide members
8.0CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
17
Hide members
8.0CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
18
Hide members
7.1CXCL12, CX3CR1, CCL2, CCR5, CCR2, CCL5

Compounds for genes affiliated with Neuroretinitis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 2BitterDB, 24HMDB
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Compounds related to Neuroretinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1triamcinolone acetonide44 2811.6SERPINF1
2anaphylatoxin4410.4CCL5
3glutamate4410.1CLN3, CS
4tak-7792810.1CCR5, CCR2
5mcp 24410.0CCL5, CCR5
6ccl22810.0CCR2, CCR5
7rantes449.9IFNG, CXCL12
8ccl11289.9CCR5, CCR2
9ccl8289.9CCR5, CCR2
10ccl16289.8CCR2, CCR5
11bicyclam449.8CCR5, CXCL12
12cyclosporin a44 28 5911.7CCL5, IFNG, CS
13cerivastatin44 49 28 1112.5ABCB1, CCL5
14cyclophosphamide44 49 1111.5CXCL12, ABCB1
15shikonin449.5CCL2, CXCL12, CCR5
16gm-csf44 2810.4CCL5, IFNG, IL10
17mcp 1449.4CCL2, IL10, CCL5
18glatiramer acetate44 1110.4IFNG, CCL5, IL10
19triptolide449.3IFNG, CCL2, CCL5
20il-12449.2IL10, IFNG, CCL2
21sdf 1449.2CCL2, CXCL12, CCR5, CCL5
22polymyxin b449.1CCL2, IFNG, IL10
23larc449.1CCL2, CCR5, CCL5, CXCL12
24pertussis449.1CCL2, CXCL12, CCL5
25cytochalasin d44 5910.1CCL2, CXCL12, CCL5, CCR5
26mip 1alpha449.0CCL2, IL10, CCR5, CCL5
27tacrolimus44 49 1111.0CCL5, ABCB1, IFNG
28ccl444 289.8CCL5, CCR5, CCL2, CX3CR1, CXCL12
29indinavir44 49 1110.8ABCB1, CCL5, CCR5, IFNG
30serine448.7CS, CCL2, CCR5, CCL5, CLN3, SERPINF1
31dexamethasone44 49 28 1111.7SERPINF1, ABCB1, CXCL12, CS, CCL5
32ritonavir44 49 1110.6CCR5, CCL5, ABCB1
33quinine44 28 2 1111.6CCR5, ABCB1, IL10, CXCL12
34mdms448.5CXCL12, CCL5, IL10, CCL2, CCR5
35groalpha448.5CCL2, CCR5, CXCL12, IL10, CCL5
36mycophenolate mofetil44 49 1110.4IL10, ABCB1, IFNG
37histamine44 28 2410.4CCL5, CCR5, CCL2, IFNG, IL10
38sb 20358044 599.4IL10, CXCL12, IFNG, CCL2, CCL5
39arginine448.3CXCL12, CCR5, CCL2, IFNG, CS, CLN3
40il 10448.2IL10, CCR5, CCL5, IL10RA, IFNG, CCL2
41nitric oxide44 11 2410.2CS, SERPINF1, CCL2, CCL5, IFNG, IL10
425fluorouracil448.2ABCB1, IFNG, CXCL12, CCL2
43genistein44 28 59 2 11 2413.1IFNG, CXCL12, ABCB1, CCL5, CCL2
44actinomycin d448.1ABCB1, CXCL12, CCL2, CCR5, IFNG
45tarc448.0CCR5, CCL5, CCL2, CXCL12, IL10, IFNG
46cholesterol44 28 11 2411.0ABCB1, CXCL12, CS, CCL2, CCL5, CCR5
47zidovudine44 118.8CXCL12, CCR5, CCL2, IL10, ABCB1, CS
48vegf447.8CCL5, CCL2, IFNG, CX3CR1, CXCL12, SERPINF1
49ccl344 288.7IFNG, CCL5, IL10, CCL2, CXCL12, CX3CR1
50simvastatin44 49 59 28 11 2412.6IL10, IFNG, CCL5, CCR5, ABCB1, CCL2

GO Terms for genes affiliated with Neuroretinitis

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16Gene Ontology
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Cellular components related to Neuroretinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.7SERPINF1, IL10, CXCL12, IFNG, CCL2, CCL5

Biological processes related to Neuroretinitis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell chemotaxisGO:01082010.0CCR2, CCL5
2positive regulation of immune complex clearance by monocytes and macrophagesGO:0902659.9CCL2, CCR2
3regulation of vascular endothelial growth factor productionGO:0105749.9CCR2, CCL2
4positive regulation of macrophage chemotaxisGO:0107599.8CCL2, CCL5
5cellular homeostasisGO:0197259.7CCL2, CCR2
6dendritic cell chemotaxisGO:0024079.7CCL5, CCR2, CCR5
7cellular defense responseGO:0069689.7CX3CR1, CCR5, CCR2
8positive regulation of monocyte chemotaxisGO:0900269.7CXCL12, CCR2, CCL5
9cellular response to fibroblast growth factor stimulusGO:0443449.6CCL2, CCL5
10macrophage chemotaxisGO:0482469.6CX3CR1, CCL2, CCL5
11positive regulation of MHC class II biosynthetic processGO:0453489.6IL10, IFNG
12positive regulation of T cell activationGO:0508709.5CCL2, CCR2
13MAPK cascadeGO:0001659.4CCL5, CCR5, CCL2
14negative regulation of angiogenesisGO:0165259.4CCR2, CCL2, CX3CR1, SERPINF1
15negative regulation of growth of symbiont in hostGO:0441309.3IL10, IFNG
16monocyte chemotaxisGO:0025489.3CCL2, CCL5
17response to virusGO:0096159.2CCL5, IFNG, CXCL12
18cellular calcium ion homeostasisGO:0068749.1CXCL12, CCL2, CCR2, CCL5
19G-protein coupled receptor signaling pathwayGO:0071868.9CCR5, CCL2, CX3CR1, CXCL12
20inflammatory responseGO:0069548.5CCL5, CCR2, CCR5, CCL2, IL10
21chemokine-mediated signaling pathwayGO:0700988.4CXCL12, CX3CR1, CCL2, CCR5, CCR2, CCL5
22cellular response to lipopolysaccharideGO:0712228.4CCR5, CCL2, IFNG, CX3CR1, IL10
23chemotaxisGO:0069358.4CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
24response to drugGO:0424938.2CCL2, IFNG, IL10, ABCB1

Molecular functions related to Neuroretinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:0164939.7CCR5, CCR2
2CCR2 chemokine receptor bindingGO:0317279.5CCL2, CCR2
3chemokine receptor activityGO:0049509.4CX3CR1, CCR5, CCR2
4chemokine activityGO:0080098.8CCL5, CCL2, CXCL12

Products for genes affiliated with Neuroretinitis

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Sources for Neuroretinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet