MCID: NRR001
MIFTS: 52

Neuroretinitis malady

Neuronal diseases category

Summaries for Neuroretinitis

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MalaCards: Neuroretinitis, also known as focal retinitis and retinochoroiditis, juxtapapillary, is related to vasculitis and glaucoma. An important gene associated with Neuroretinitis is GORAB (golgin, RAB6-interacting), and among its related pathways are Spinal Cord Injury and A-beta Uptake & Degradation. The compounds triamcinolone acetonide and anaphylatoxin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Aliases & Classifications for Neuroretinitis

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroretinitis 8 60
focal retinitis and retinochoroiditis, juxtapapillary 8
juxtapapillary focal retinitis and retinochoroiditis 8
papilloretinitis 8


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Disease Ontology8 DOID:10176
ICD9CM27 363.05
SNOMED-CT56 46497009, 410471004
MeSH34 D012173

Related Diseases for Neuroretinitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neuroretinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.9CCL2
2glaucoma30.4SERPINF1
3hypertension30.3CCL2
4retinal detachment30.1SERPINF1
5multiple sclerosis30.1CCL5, CCR2, CCR5, CCL2, IFNG, CX3CR1
6eye disease30.0CCL2
7uveitis30.0SERPINF1, IL10, IFNG, CCL2, CCR5
8neuritis29.8CCL5
9herpes simplex29.8CCL5
10hepatitis29.8CXCL12
11diabetic retinopathy29.8SERPINF1, CXCL12
12macular retinal edema29.8CXCL12, SERPINF1
13encephalitis29.7CCL2, CCR5, CCL5
14hepatitis c29.7CCR5, IFNG, IL10
15sarcoidosis29.7CCL5, CCR5, CCL2, IFNG
16leukemia29.7IFNG, CXCL12, ABCB1, SERPINF1
17retinitis10.7
18cat-scratch disease10.6
19retinal vasculitis10.6
20toxocariasis10.2
21toxoplasmosis10.2
22antiphospholipid syndrome10.1
23choroiditis10.1
24ocular hypertension10.1
25lyme disease10.1
26retinal artery occlusion10.1
27syphilis10.1
28branch retinal artery occlusion10.0
29cysticercosis10.0
30aseptic meningitis10.0
31chikungunya10.0
32mumps10.0
33hypertensive retinopathy10.0
34meningitis10.0
35hyperglycemia10.0SERPINF1
36spotted fever10.0CS
37bronchiolitis10.0CCL5
38chagas disease10.0CCR5
39polymyalgia rheumatica10.0CCL5
40rhinitis10.0CCL5
41age related macular degeneration10.0CX3CR1
42acute myocardial infarction10.0CCL5
43retinoblastoma10.0SERPINF1
44myopathy10.0CS
45wegener's granulomatosis10.0CCR5
46synovitis10.0CX3CR1
47guillain-barre syndrome10.0CCR5
48essential hypertension10.0CCR5
49ischemia10.0CXCL12
50pancreatic cancer10.0CXCL12

Graphical network of the top 20 diseases related to Neuroretinitis:



Diseases related to neuroretinitis

Clinical Features for Neuroretinitis

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Drugs & Therapeutics for Neuroretinitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Neuroretinitis

Genetic Tests for Neuroretinitis

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Anatomical Context for Neuroretinitis

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32MalaCards
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MalaCards organs/tissues related to Neuroretinitis:

32
Eye, Retina, Brain, Testes

Animal Models for Neuroretinitis or affiliated genes

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36MGI
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Publications for Neuroretinitis

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50PubMed
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Articles related to Neuroretinitis:

(show top 50)    (show all 240)
idTitleAuthorsYear
1
Neuroretinitis: a rare feature of tubulointerstitial nephritis and uveitis syndrome. (23824660)
2013
2
Idiopathic retinal vasculitis, arteriolar macroaneurysms and neuroretinitis: clinical course and treatment. (23514018)
2013
3
Detection of glaucoma with an optical coherence tomography-derived neuroretinal rim parameter. (24182570)
2013
4
Painful labia ulceration and neuroretinal cat scratch disease. (24008744)
2013
5
Dexamethasone intravitreal implant for idiopathic retinal vasculitis, aneurysms, and neuroretinitis. (23661543)
2013
6
Oxidative stress-associated neuroretinal dysfunction and nitrosative stress in diabetic retinopathy. (24321721)
2013
7
Neuroretinitis and intracranial venous thrombosis in antiphospholipid syndrome. (23246217)
2012
8
Leptospirosis presenting as neuroretinitis. (22865992)
2012
9
Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy. (22342523)
2012
10
Rapid regression of exudative maculopathy in idiopathic retinitis, vasculitis, aneurysms and neuroretinitis syndrome after intravitreal ranibizumab. (22949913)
2012
11
Clinical features of 121 patients with diffuse unilateral subacute neuroretinitis. (22244523)
2012
12
Early treatment of idiopathic vasculitis, aneurysms and neuroretinitis (IRVAN). A case report. (24269400)
2012
13
Syphilitic bilateral neuroretinitis--a case report. (22783746)
2012
14
Infliximab therapy for idiopathic retinal vasculitis, aneurysm, and neuroretinitis syndrome. (21563921)
2011
15
Retinal nerve fiber layer atrophy as relevant feature for diffuse unilateral subacute neuroretinitis (DUSN): case series. (20549051)
2010
16
Recurrent idiopathic neuroretinitis: natural history and effect of treatment. (20704588)
2010
17
Disseminated bartonellosis presenting as neuroretinitis in a young adult with human immunodeficiency virus infection. (20216243)
2010
18
Retinal angiography and optical coherence tomography disclose focal optic disc vascular leakage and lipid-rich fluid accumulation within the retina in a patient with leber idiopathic stellate neuroretinitis. (19726942)
2009
19
Cat scratch disease complicated with aseptic meningitis and neuroretinitis. (18641856)
2008
20
Diffuse unilateral subacute neuroretinitis in Africa. (16507494)
2006
21
The Indian case of live worm in diffuse unilateral subacute neuroretinitis. (15920564)
2006
22
Central serous retinal detachment detected by optical coherence tomography in Leber's idiopathic stellate neuroretinitis. (16365812)
2005
23
Pattern visual evoked potentials in eyes with disc swelling due to cat scratch disease-associated neuroretinitis. (16328936)
2005
24
Bartonella henselae infection associated with neuroretinitis, central retinal artery and vein occlusion, neovascular glaucoma, and severe vision loss. (14700670)
2004
25
Long term follow up in a case of successfully treated idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN). (14736797)
2004
26
Decreased levels of pigment epithelium-derived factor in eyes with neuroretinal dystrophic diseases. (15183804)
2004
27
A case of cat scratch disease neuroretinitis confirmed by polymerase chain reaction. (12842212)
2003
28
Bilateral neuroretinitis in a 6-year-old boy with acquired toxoplasmosis. (14557195)
2003
29
Resolution of chicken pox neuroretinitis with oral acyclovir: a case report. (14704904)
2003
30
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) with preserved perfusion. (12972774)
2003
31
Cat-scratch disease neuroretinitis diagnosed by a polymerase chain reaction approach. (11589885)
2001
32
Pars plana vitrectomy for epiretinal membrane secondary to cat scratch neuroretinitis. (11421023)
2001
33
Leber's idiopathic stellate neuroretinitis. (11714123)
2001
34
Bartonella henselae neuroretinitis. (11531989)
2001
35
Neuroretinitis: a clinical syndrome of cat-scratch disease. (11137430)
2000
36
Tuberculous neuroretinitis. (10494950)
1999
37
Regression of retinal arterial aneurysms in a case of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN). (10380034)
1999
38
Hypertensive retinopathy simulating Leber idiopathic stellate neuroretinitis. (9400800)
1997
39
Diffuse unilateral subacute neuroretinitis. Report of transvitreal surgical removal of a subretinal nematode. (9097745)
1995
40
Neuroretinitis associated with melanocytoma of the optic disk. (8036328)
1994
41
The neuroretinal rim in descending optic atrophy. (1577296)
1992
42
Oral therapy in diffuse unilateral subacute neuroretinitis. (1580843)
1992
43
Neuroretinitis associated with cat scratch disease. (2248340)
1990
44
Diffuse unilateral subacute neuroretinitis. (20894230)
1978
45
Diffuse unilateral subacute neuroretinitis. (673332)
1978
46
THREE CASES OF RETINITIS PSEUDO-NEPHRITICA STELLATA. CONSIDERATIONS ON THE PATHOGENESIS OF NEURORETINITIS IN GENERAL. (18168999)
1931
47
Report of a Case of Detachment of the Retina Occurring in a Case of Neuroretinitis, Relieved by Scleral Trephining Operation, Associated with Incision of the Choroid and Retina. No Recurrence After a Period of Eight Months. (16692310)
1914
48
Retinitis Pigmentosa Associated with Albuminuric Neuroretinitis. (16692246)
1911
49
Neuroretinitis in Chlorosis, with Report of a Case. (16692175)
1909
50
The Channel by which, in Cases of Neuroretinitis, the Exudation proceeds from the Brain into the Eye. (16691681)
1870

Genetic Variations for Neuroretinitis

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Expression for genes affiliated with Neuroretinitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroretinitis

Search GEO for disease gene expression data for Neuroretinitis.

Pathways for genes affiliated with Neuroretinitis

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Sources:
37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Neuroretinitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CCL2, CCR2
29.3CX3CR1, CCL2, CCR2
3
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9.3IL10RA, CCL2, CCL5
4
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9.2CCL2, CCR5, CCL5
59.1IFNG, CCL2, CCR2
68.7CCL5, CCR2, CXCL12, IL10
7
Hide members
8.6CCR2, CCR5, CX3CR1, CXCL12, IL10RA
8
Hide members
8.6IL10, IL10RA, IFNG, CCR5
9
Hide members
8.6IFNG, CXCL12, IL10RA, IL10
10
Development PDGF signaling via STATs and NF-kB
Hide members
8.5CCL2, IFNG, IL10RA, IL10
11
Hide members
8.4CCL5, CCL2, IFNG, IL10
12
Hide members
8.4CCL5, CCR2, CCR5, CCL2, CXCL12
13
Hide members
8.4SERPINF1, IL10RA, CXCL12, CX3CR1, CCR5, CCR2
14
Hide members
8.3IL10RA, CXCL12, CX3CR1, CCR5, CCR2, CCL5
158.0CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
16
Hide members
8.0CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
17
Hide members
8.0CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
18
Hide members
7.1CXCL12, CX3CR1, CCL2, CCR5, CCR2, CCL5

Compounds for genes affiliated with Neuroretinitis

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 2BitterDB, 24HMDB
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Compounds related to Neuroretinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1triamcinolone acetonide44 2811.6SERPINF1
2anaphylatoxin4410.4CCL5
3glutamate4410.1CLN3, CS
4tak-7792810.1CCR5, CCR2
5mcp 24410.0CCL5, CCR5
6ccl22810.0CCR2, CCR5
7rantes449.9IFNG, CXCL12
8ccl11289.9CCR5, CCR2
9ccl8289.9CCR5, CCR2
10ccl16289.8CCR2, CCR5
11bicyclam449.8CCR5, CXCL12
12cyclosporin a44 28 5911.7CCL5, IFNG, CS
13cerivastatin44 49 28 1112.5ABCB1, CCL5
14cyclophosphamide44 49 1111.5CXCL12, ABCB1
15shikonin449.5CCL2, CXCL12, CCR5
16gm-csf44 2810.4CCL5, IFNG, IL10
17mcp 1449.4CCL2, IL10, CCL5
18glatiramer acetate44 1110.4IFNG, CCL5, IL10
19triptolide449.3IFNG, CCL2, CCL5
20il-12449.2IL10, IFNG, CCL2
21sdf 1449.2CCL2, CXCL12, CCR5, CCL5
22polymyxin b449.1CCL2, IFNG, IL10
23larc449.1CCL2, CCR5, CCL5, CXCL12
24pertussis449.1CCL2, CXCL12, CCL5
25cytochalasin d44 5910.1CCL2, CXCL12, CCL5, CCR5
26mip 1alpha449.0CCL2, IL10, CCR5, CCL5
27tacrolimus44 49 1111.0CCL5, ABCB1, IFNG
28ccl444 289.8CCL5, CCR5, CCL2, CX3CR1, CXCL12
29indinavir44 49 1110.8ABCB1, CCL5, CCR5, IFNG
30serine448.7CS, CCL2, CCR5, CCL5, CLN3, SERPINF1
31dexamethasone44 49 28 1111.7SERPINF1, ABCB1, CXCL12, CS, CCL5
32ritonavir44 49 1110.6CCR5, CCL5, ABCB1
33quinine44 28 2 1111.6CCR5, ABCB1, IL10, CXCL12
34mdms448.5CXCL12, CCL5, IL10, CCL2, CCR5
35groalpha448.5CCL2, CCR5, CXCL12, IL10, CCL5
36mycophenolate mofetil44 49 1110.4IL10, ABCB1, IFNG
37histamine44 28 2410.4CCL5, CCR5, CCL2, IFNG, IL10
38sb 20358044 599.4IL10, CXCL12, IFNG, CCL2, CCL5
39arginine448.3CXCL12, CCR5, CCL2, IFNG, CS, CLN3
40il 10448.2IL10, CCR5, CCL5, IL10RA, IFNG, CCL2
41nitric oxide44 11 2410.2CS, SERPINF1, CCL2, CCL5, IFNG, IL10
425fluorouracil448.2ABCB1, IFNG, CXCL12, CCL2
43genistein44 28 59 2 11 2413.1IFNG, CXCL12, ABCB1, CCL5, CCL2
44actinomycin d448.1ABCB1, CXCL12, CCL2, CCR5, IFNG
45tarc448.0CCR5, CCL5, CCL2, CXCL12, IL10, IFNG
46cholesterol44 28 11 2411.0ABCB1, CXCL12, CS, CCL2, CCL5, CCR5
47zidovudine44 118.8CXCL12, CCR5, CCL2, IL10, ABCB1, CS
48vegf447.8CCL5, CCL2, IFNG, CX3CR1, CXCL12, SERPINF1
49ccl344 288.7IFNG, CCL5, IL10, CCL2, CXCL12, CX3CR1
50simvastatin44 49 59 28 11 2412.6IL10, IFNG, CCL5, CCR5, ABCB1, CCL2

GO Terms for genes affiliated with Neuroretinitis

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16Gene Ontology
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Cellular components related to Neuroretinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.7SERPINF1, IL10, CXCL12, IFNG, CCL2, CCL5

Biological processes related to Neuroretinitis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell chemotaxisGO:01082010.0CCR2, CCL5
2positive regulation of immune complex clearance by monocytes and macrophagesGO:0902659.9CCL2, CCR2
3regulation of vascular endothelial growth factor productionGO:0105749.9CCR2, CCL2
4positive regulation of macrophage chemotaxisGO:0107599.8CCL2, CCL5
5cellular homeostasisGO:0197259.7CCL2, CCR2
6dendritic cell chemotaxisGO:0024079.7CCL5, CCR2, CCR5
7cellular defense responseGO:0069689.7CX3CR1, CCR5, CCR2
8positive regulation of monocyte chemotaxisGO:0900269.7CXCL12, CCR2, CCL5
9cellular response to fibroblast growth factor stimulusGO:0443449.6CCL2, CCL5
10macrophage chemotaxisGO:0482469.6CX3CR1, CCL2, CCL5
11positive regulation of MHC class II biosynthetic processGO:0453489.6IL10, IFNG
12positive regulation of T cell activationGO:0508709.5CCL2, CCR2
13MAPK cascadeGO:0001659.4CCL5, CCR5, CCL2
14negative regulation of angiogenesisGO:0165259.4CCR2, CCL2, CX3CR1, SERPINF1
15negative regulation of growth of symbiont in hostGO:0441309.3IL10, IFNG
16monocyte chemotaxisGO:0025489.3CCL2, CCL5
17response to virusGO:0096159.2CCL5, IFNG, CXCL12
18cellular calcium ion homeostasisGO:0068749.1CXCL12, CCL2, CCR2, CCL5
19G-protein coupled receptor signaling pathwayGO:0071868.9CCR5, CCL2, CX3CR1, CXCL12
20inflammatory responseGO:0069548.5CCL5, CCR2, CCR5, CCL2, IL10
21chemokine-mediated signaling pathwayGO:0700988.4CXCL12, CX3CR1, CCL2, CCR5, CCR2, CCL5
22cellular response to lipopolysaccharideGO:0712228.4CCR5, CCL2, IFNG, CX3CR1, IL10
23chemotaxisGO:0069358.4CCL5, CCR2, CCR5, CCL2, CX3CR1, CXCL12
24response to drugGO:0424938.2CCL2, IFNG, IL10, ABCB1

Molecular functions related to Neuroretinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:0164939.7CCR5, CCR2
2CCR2 chemokine receptor bindingGO:0317279.5CCL2, CCR2
3chemokine receptor activityGO:0049509.4CX3CR1, CCR5, CCR2
4chemokine activityGO:0080098.8CCL5, CCL2, CXCL12

Products for genes affiliated with Neuroretinitis

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Sources for Neuroretinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet