MCID: NRS005
MIFTS: 23

Neurosarcoidosis

Categories: Neuronal diseases

Aliases & Classifications for Neurosarcoidosis

MalaCards integrated aliases for Neurosarcoidosis:

Name: Neurosarcoidosis 51 69

Classifications:



Summaries for Neurosarcoidosis

NINDS : 51 Neurosarcoidosis is a manifestation of sarcoidosis in the nervous system.  Sarcoidosis is a chronic inflammatory disorder that typically occurs in adults between 20 and 40 years of age and primarily affects the lungs, but can also impact almost every other organ and system in the body.  Neurosarcoidosis is characterized by inflammation and abnormal cell deposits in any part of the nervous system – the brain, spinal cord, or peripheral nerves.  It most commonly occurs in the cranial and facial nerves, the hypothalamus (a specific area of the brain), and the pituitary gland.  It is estimated to develop in 5 to 15 percent of those individuals who have sarcoidosis.  Weakness of the facial muscles on one side of the face (Bell’s palsy) is a common symptom of neurosarcoidosis.  The optic and auditory nerves can also become involved, causing vision and hearing impairments.  It can cause headache, seizures, memory loss, hallucinations, irritability, agitation, and changes in mood and behavior.  Neurosarcoidosis can appear in an acute, explosive fashion or start as a slow chronic illness.  Because neurosarcoidosis manifests in many different ways, a diagnosis may be difficult and delayed.

MalaCards based summary : Neurosarcoidosis is related to hydrocephalus and meningitis. An important gene associated with Neurosarcoidosis is ACE (Angiotensin I Converting Enzyme). The drugs Adrenocorticotropic Hormone and beta-endorphin have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and spinal cord.

Wikipedia : 72 Neurosarcoidosis (sometimes shortened to neurosarcoid) refers to sarcoidosis, a condition of unknown... more...

Related Diseases for Neurosarcoidosis

Diseases related to Neurosarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Related Disease Score Top Affiliating Genes
1 hydrocephalus 10.0
2 meningitis 10.0
3 diabetes insipidus 9.9
4 neuropathy 9.9
5 headache 9.8
6 myelitis 9.8
7 cerebritis 9.8
8 transverse myelitis 9.8
9 amenorrhea 9.7
10 rheumatoid arthritis 9.6
11 arthritis 9.6
12 common variable immunodeficiency 9.6
13 thrombosis 9.6
14 choroiditis 9.6
15 multiple cranial nerve palsy 9.6
16 cranial nerve palsy 9.6
17 tuberculosis 9.6
18 hypopituitarism 9.6
19 encephalitis 9.6
20 glioma 9.6
21 idiopathic hypertrophic pachymeningitis 9.6
22 ataxia 9.6
23 encephalopathy 9.6
24 tremor 9.6
25 schizophrenia 9.5
26 acne 9.5
27 hepatitis 9.5
28 pulmonary sarcoidosis 9.5
29 sinusitis 9.5
30 sensorineural hearing loss 9.5
31 chronic meningitis 9.5
32 meningoencephalitis 9.5
33 acute cervicitis 9.5
34 respiratory failure 9.5
35 schizophreniform disorder 9.5
36 aseptic meningitis 9.5
37 dementia 9.5
38 phaeohyphomycosis 9.5
39 obstructive hydrocephalus 9.5
40 argyll robertson pupil 9.5
41 papilledema 9.5
42 labyrinthitis 9.5
43 status epilepticus 9.5
44 epilepsy 9.5
45 mononeuritis multiplex 9.5
46 hepatitis c 9.5
47 hypogonadism 9.5
48 lateral sclerosis 9.5
49 granulomatous angiitis 9.5
50 cervicitis 9.5

Graphical network of the top 20 diseases related to Neurosarcoidosis:



Diseases related to Neurosarcoidosis

Symptoms & Phenotypes for Neurosarcoidosis

Drugs & Therapeutics for Neurosarcoidosis

Drugs for Neurosarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Adrenocorticotropic Hormone
2 beta-endorphin
3 Hormone Antagonists
4 Hormones
5 Hormones, Hormone Substitutes, and Hormone Antagonists
6 Melanocyte-Stimulating Hormones

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Analysis of the Distribution of Regulatory B Cells in Blood of Multiple Sclerosis Patients Recruiting NCT02789670
2 ACTHAR Therapy for Central Nervous System Sarcoidosis Not yet recruiting NCT02920710 Repository Corticotropin Injection

Search NIH Clinical Center for Neurosarcoidosis

Genetic Tests for Neurosarcoidosis

Anatomical Context for Neurosarcoidosis

MalaCards organs/tissues related to Neurosarcoidosis:

39
Brain, Lung, Spinal Cord, Pituitary, Testes, Hypothalamus, B Cells

Publications for Neurosarcoidosis

Articles related to Neurosarcoidosis:

(show top 50) (show all 460)
id Title Authors Year
1
Propionibacterium acnes-associated neurosarcoidosis: A case report with review of the literature. ( 28856748 )
2017
2
Neurosarcoidosis on FET and FDG PET/CT. ( 28045730 )
2017
3
Neurosarcoidosis according to Zajicek and Scolding criteria: 15 probable and definite cases, their treatment and outcomes. ( 28716286 )
2017
4
Neurosarcoidosis presenting as an incidental solitary cranial ring-enhancing lesion. ( 28761540 )
2017
5
Neurosarcoidosis: leptomeninigeal, cavernous sinus and pituitary involvement. ( 28186582 )
2017
6
Neurosarcoidosis: clinical presentations and changing treatment patterns in an Irish Caucasian population. ( 28101825 )
2017
7
Many faces of neurosarcoidosis: from chronic meningitis to myelopathy. ( 28598872 )
2017
8
Search for biomarkers of neurosarcoidosis by proteomic analysis of cerebrospinal fluid. ( 28751284 )
2017
9
Massive Neurosarcoidosis. ( 28824053 )
2017
10
Neurosarcoidosis Presenting With Recurrent Strokes: A Case Report and Literature Review. ( 28400903 )
2017
11
Neurosarcoidosis. ( 28750463 )
2017
12
(18)F-FDG-PET/CT guiding to diagnosis of neurosarcoidosis. ( 28219645 )
2017
13
Characteristics and Long-Term Outcome of Neurosarcoidosis: A Population-Based Study from 1976-2013. ( 28601860 )
2017
14
Long-term outcomes of refractory neurosarcoidosis treated with infliximab. ( 28260120 )
2017
15
Neurosarcoidosis and multiple intracerebral hematomas: An unusual clinical presentation. ( 28716245 )
2017
16
A Rare Case of Neurosarcoidosis Presenting as Severe Hypothermia. ( 28484206 )
2017
17
(18)F-FDG PET/CT helps in unmasking the great mimicker: A case of neurosarcoidosis with isolated involvement of the spinal cord. ( 28526323 )
2017
18
"Hot-cross bun" and "inverse trident sign' in neurosarcoidosis: An important finding. ( 28084265 )
2017
19
Leptomeningeal Infiltration, the Hallmark of Neurosarcoidosis. ( 28389310 )
2017
20
Neurosarcoidosis-induced longitudinal extensive transverse myelitis. ( 28879911 )
2017
21
Isolated Central Nervous System Vasculitis as a Manifestation of Neurosarcoidosis. ( 27083067 )
2016
22
Unusual Presentation of Central Diabetes Insipidus in a Patient With Neurosarcoidosis. ( 27652275 )
2016
23
Neurosarcoidosis in Pediatric Patients: A Case Report and Review of Isolated and Systemic Neurosarcoidosis. ( 27524272 )
2016
24
Neurosarcoidosis Presenting as Aseptic Meningitis in an Immunosuppressed Renal Transplant Recipient. ( 26863472 )
2016
25
Isolated neurosarcoidosis presenting with multiple cranial nerve palsies. ( 27168947 )
2016
26
Neurosarcoidosis in a Tertiary Referral Center: A Cross-Sectional Cohort Study. ( 27057889 )
2016
27
NEUROSARCOIDOSIS MASQUERADING AS A CENTRAL NERVOUS SYSTEM TUMOR. ( 27571425 )
2016
28
The devil is in the detail: Acute Guillain-BarrAc syndrome camouflaged as neurosarcoidosis in a critically ill patient admitted to an Intensive Care Unit. ( 27303139 )
2016
29
Teaching NeuroImages: Recurrent oculomotor palsies caused by neurosarcoidosis. ( 27432184 )
2016
30
Intractable Neurosarcoidosis Effectively Treated with Infliximab. ( 27041170 )
2016
31
Poster 348 Biospy-Confirmed Neurosarcoidosis Manifesting as a Non-Compressive Myelopathy with Transverse Myelitis and Normal ACE Level: A Case Study. ( 27673101 )
2016
32
Challenges in the diagnosis and treatment of neurosarcoidosis. ( 26469296 )
2015
33
Neurosarcoidosis as an MS Mimic: The trials and tribulations of making a diagnosis. ( 26346790 )
2015
34
Vertigo as a predominant manifestation of neurosarcoidosis. ( 25922606 )
2015
35
Isolated neurosarcoidosis mimicking intracranial tumours - Analysis of 3 cases. ( 25773910 )
2015
36
Nemesis of neglected neurosarcoidosis. ( 26478894 )
2015
37
A case of relapsing neurosarcoidosis with brain nodules and hydrocephalus successfully treated by corticosteroid and methotrexate. ( 25957441 )
2015
38
Neurosarcoidosis presenting as status epilepticus: a new bronchoscopic complication. ( 25887017 )
2015
39
Fine mapping of chromosome 15q25 implicates ZNF592 in neurosarcoidosis patients. ( 26478897 )
2015
40
Neurosarcoidosis: diagnosis, therapy and biomarkers. ( 25936846 )
2015
41
Neurosarcoidosis-associated central diabetes insipidus masked by adrenal insufficiency. ( 25612752 )
2015
42
A rare comorbidity: neurosarcoidosis and cutaneous sarcoidosis. ( 26578505 )
2015
43
Girdle Sensation Caused by Radiculitis due to Neurosarcoidosis. ( 26073252 )
2015
44
A CASE OF PROBABLE NEUROSARCOIDOSIS PRESENTING AS UNILATERAL OPHTHALMOPLEGIA. ( 26666108 )
2015
45
Endoscopic biopsy for the diagnosis of neurosarcoidosis at the fourth ventricle outlet with hydrocephalus. ( 26682088 )
2015
46
Cerebrospinal fluid angiotensin-converting enzyme for diagnosis of neurosarcoidosis. ( 26198911 )
2015
47
An unusual cause of sudden hearing loss. Probable neurosarcoidosis (NS). ( 25375245 )
2015
48
Gasserian ganglion neurosarcoidosis mimicking trigeminal schwannoma. ( 25742592 )
2015
49
Neurosarcoidosis mimicking bilateral posterior fossa tentorial meningiomas. ( 26341372 )
2015
50
A case of neurosarcoidosis secondary to treatment of etanercept and review of the literature. ( 26150616 )
2015

Variations for Neurosarcoidosis

Expression for Neurosarcoidosis

Search GEO for disease gene expression data for Neurosarcoidosis.

Pathways for Neurosarcoidosis

GO Terms for Neurosarcoidosis

Sources for Neurosarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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