MCID: NRS005
MIFTS: 26

Neurosarcoidosis

Categories: Neuronal diseases

Aliases & Classifications for Neurosarcoidosis

MalaCards integrated aliases for Neurosarcoidosis:

Name: Neurosarcoidosis 50 69

Classifications:



External Ids:

UMLS 69 C0393485

Summaries for Neurosarcoidosis

NINDS : 50 Neurosarcoidosis is a manifestation of sarcoidosis in the nervous system.  Sarcoidosis is a chronic inflammatory disorder that typically occurs in adults between 20 and 40 years of age and primarily affects the lungs, but can also impact almost every other organ and system in the body.  Neurosarcoidosis is characterized by inflammation and abnormal cell deposits in any part of the nervous system – the brain, spinal cord, or peripheral nerves.  It most commonly occurs in the cranial and facial nerves, the hypothalamus (a specific area of the brain), and the pituitary gland.  It is estimated to develop in 5 to 15 percent of those individuals who have sarcoidosis.  Weakness of the facial muscles on one side of the face (Bell’s palsy) is a common symptom of neurosarcoidosis.  The optic and auditory nerves can also become involved, causing vision and hearing impairments.  It can cause headache, seizures, memory loss, hallucinations, irritability, agitation, and changes in mood and behavior.  Neurosarcoidosis can appear in an acute, explosive fashion or start as a slow chronic illness.  Because neurosarcoidosis manifests in many different ways, a diagnosis may be difficult and delayed.

MalaCards based summary : Neurosarcoidosis is related to hydrocephalus and meningitis. An important gene associated with Neurosarcoidosis is ACE (Angiotensin I Converting Enzyme). The drugs beta-endorphin and Adrenocorticotropic Hormone have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and spinal cord.

Wikipedia : 72 Neurosarcoidosis (sometimes shortened to neurosarcoid) refers to sarcoidosis, a condition of unknown... more...

Related Diseases for Neurosarcoidosis

Diseases related to Neurosarcoidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 hydrocephalus 10.1
2 meningitis 10.1
3 meningioma, familial 10.1
4 diabetes insipidus 10.0
5 neuropathy 10.0
6 headache 9.9
7 diabetes insipidus, neurohypophyseal 9.9
8 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
9 multiple sclerosis 9.9
10 myelitis 9.9
11 cerebritis 9.9
12 transverse myelitis 9.9
13 episodic pain syndrome, familial, 1 9.8
14 amenorrhea 9.8
15 mycobacterium tuberculosis 1 9.7
16 encephalopathy 9.7
17 choroiditis 9.7
18 arthritis 9.7
19 hypopituitarism 9.7
20 tremor 9.7
21 common variable immunodeficiency 9.7
22 multiple cranial nerve palsy 9.7
23 rheumatoid arthritis 9.7
24 encephalitis 9.7
25 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.7
26 thrombosis 9.7
27 cranial nerve palsy 9.7
28 glioma 9.7
29 pituitary hormone deficiency, combined, 2 9.7
30 idiopathic hypertrophic pachymeningitis 9.7
31 ataxia and polyneuropathy, adult-onset 9.7
32 respiratory failure 9.6
33 hepatitis c 9.6
34 acute disseminated encephalomyelitis 9.6
35 dysphagia 9.6
36 schizophreniform disorder 9.6
37 hypogonadism 9.6
38 nervous system disease 9.6
39 amenorrhea-galactorrhea syndrome 9.6
40 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.6
41 lateral sclerosis 9.6
42 vasculitis 9.6
43 amyotrophic lateral sclerosis 1 9.6
44 aseptic meningitis 9.6
45 central nervous system origin vertigo 9.6
46 hypersomnia 9.6
47 seizures, benign familial neonatal, 1 9.6
48 dementia 9.6
49 granulomatous angiitis 9.6
50 narcolepsy 9.6

Graphical network of the top 20 diseases related to Neurosarcoidosis:



Diseases related to Neurosarcoidosis

Symptoms & Phenotypes for Neurosarcoidosis

Drugs & Therapeutics for Neurosarcoidosis

Drugs for Neurosarcoidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 beta-endorphin Phase 4
2 Adrenocorticotropic Hormone Phase 4
3 Hormone Antagonists Phase 4
4 Hormones Phase 4
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
6 Melanocyte-Stimulating Hormones Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ACTHAR Therapy for Central Nervous System Sarcoidosis Not yet recruiting NCT02920710 Phase 4 Repository Corticotropin Injection
2 Analysis of the Distribution of Regulatory B Cells in Blood of Multiple Sclerosis Patients Recruiting NCT02789670

Search NIH Clinical Center for Neurosarcoidosis

Genetic Tests for Neurosarcoidosis

Anatomical Context for Neurosarcoidosis

MalaCards organs/tissues related to Neurosarcoidosis:

38
Brain, Lung, Spinal Cord, Pituitary, Testes, Hypothalamus, B Cells

Publications for Neurosarcoidosis

Articles related to Neurosarcoidosis:

(show top 50) (show all 469)
# Title Authors Year
1
Neurosarcoidosis associated with intracerebral haemorrhage: a challenge in diagnosis and management. ( 29363557 )
2018
2
Leptomeningeal Infiltration, the Hallmark of Neurosarcoidosis. ( 28389310 )
2017
3
Neurosarcoidosis on FET and FDG PET/CT. ( 28045730 )
2017
4
Neurosarcoidosis. ( 28750463 )
2017
5
Extrapyramidal signs in neurosarcoidosis versus multiple sclerosis: Is TNF alpha the link? ( 29054587 )
2017
6
Massive Neurosarcoidosis. ( 28824053 )
2017
7
Neurosarcoidosis: leptomeninigeal, cavernous sinus and pituitary involvement. ( 28186582 )
2017
8
(18)F-FDG-PET/CT guiding to diagnosis of neurosarcoidosis. ( 28219645 )
2017
9
Neurosarcoidosis: clinical presentations and changing treatment patterns in an Irish Caucasian population. ( 28101825 )
2017
10
The Protean Neuropsychiatric and Vestibuloauditory Manifestations of Neurosarcoidosis. ( 29166635 )
2017
11
Neurosarcoidosis according to Zajicek and Scolding criteria: 15 probable and definite cases, their treatment and outcomes. ( 28716286 )
2017
12
Search for biomarkers of neurosarcoidosis by proteomic analysis of cerebrospinal fluid. ( 28751284 )
2017
13
Neurosarcoidosis Presenting With Recurrent Strokes: A Case Report and Literature Review. ( 28400903 )
2017
14
Propionibacterium acnes-associated neurosarcoidosis: A case report with review of the literature. ( 28856748 )
2017
15
Association of Prognostic Factors and Immunosuppressive Treatment With Long-term Outcomes in Neurosarcoidosis. ( 29052709 )
2017
16
A Rare Case of Neurosarcoidosis Presenting as Severe Hypothermia. ( 28484206 )
2017
17
Demystifying Neurosarcoidosis and Informing Prognosis. ( 29052731 )
2017
18
(18)F-FDG PET/CT helps in unmasking the great mimicker: A case of neurosarcoidosis with isolated involvement of the spinal cord. ( 28526323 )
2017
19
"Hot-cross bun" and "inverse trident sign' in neurosarcoidosis: An important finding. ( 28084265 )
2017
20
Neurosarcoidosis and multiple intracerebral hematomas: An unusual clinical presentation. ( 28716245 )
2017
21
Neurosarcoidosis. ( 29061245 )
2017
22
Many faces of neurosarcoidosis: from chronic meningitis to myelopathy. ( 28598872 )
2017
23
Characteristics and Long-Term Outcome of Neurosarcoidosis: A Population-Based Study from 1976-2013. ( 28601860 )
2017
24
Cerebrovascular Manifestations of Neurosarcoidosis: An Underrecognized Aspect of the Imaging Spectrum. ( 29284603 )
2017
25
Long-term outcomes of refractory neurosarcoidosis treated with infliximab. ( 28260120 )
2017
26
Nodular Leptomeningeal Enhancement in Neurosarcoidosis: Before and After Treatment. ( 28975003 )
2017
27
Neurosarcoidosis presenting as an incidental solitary cranial ring-enhancing lesion. ( 28761540 )
2017
28
Neurosarcoidosis-induced longitudinal extensive transverse myelitis. ( 28879911 )
2017
29
Poster 348 Biospy-Confirmed Neurosarcoidosis Manifesting as a Non-Compressive Myelopathy with Transverse Myelitis and Normal ACE Level: A Case Study. ( 27673101 )
2016
30
Neurosarcoidosis in Pediatric Patients: A Case Report and Review of Isolated and Systemic Neurosarcoidosis. ( 27524272 )
2016
31
Unusual Presentation of Central Diabetes Insipidus in a Patient With Neurosarcoidosis. ( 27652275 )
2016
32
Neurosarcoidosis Presenting as Aseptic Meningitis in an Immunosuppressed Renal Transplant Recipient. ( 26863472 )
2016
33
Intractable Neurosarcoidosis Effectively Treated with Infliximab. ( 27041170 )
2016
34
Teaching NeuroImages: Recurrent oculomotor palsies caused by neurosarcoidosis. ( 27432184 )
2016
35
Neurosarcoidosis in a Tertiary Referral Center: A Cross-Sectional Cohort Study. ( 27057889 )
2016
36
Isolated neurosarcoidosis presenting with multiple cranial nerve palsies. ( 27168947 )
2016
37
Isolated Central Nervous System Vasculitis as a Manifestation of Neurosarcoidosis. ( 27083067 )
2016
38
NEUROSARCOIDOSIS MASQUERADING AS A CENTRAL NERVOUS SYSTEM TUMOR. ( 27571425 )
2016
39
The devil is in the detail: Acute Guillain-BarrAc syndrome camouflaged as neurosarcoidosis in a critically ill patient admitted to an Intensive Care Unit. ( 27303139 )
2016
40
Neurosarcoidosis as an MS Mimic: The trials and tribulations of making a diagnosis. ( 26346790 )
2015
41
1260: NEUROSARCOIDOSIS INDUCED PANHYPOPITUITARISM. ( 26570921 )
2015
42
Endoscopic biopsy for the diagnosis of neurosarcoidosis at the fourth ventricle outlet with hydrocephalus. ( 26682088 )
2015
43
Hashimoto encephalopathy or neurosarcoidosis? A case report. ( 25829987 )
2015
44
Gasserian ganglion neurosarcoidosis mimicking trigeminal schwannoma. ( 25742592 )
2015
45
Challenges in the diagnosis and treatment of neurosarcoidosis. ( 26469296 )
2015
46
A rare comorbidity: neurosarcoidosis and cutaneous sarcoidosis. ( 26578505 )
2015
47
Hypocretin Deficiency Associated with Narcolepsy Type 1 and Central Hypoventilation Syndrome in Neurosarcoidosis of the Hypothalamus. ( 25979096 )
2015
48
Girdle Sensation Caused by Radiculitis due to Neurosarcoidosis. ( 26073252 )
2015
49
Spinal cord hemorrhage in a patient with neurosarcoidosis on long-term corticosteroid therapy: case report. ( 26224095 )
2015
50
A case of neurosarcoidosis secondary to treatment of etanercept and review of the literature. ( 26150616 )
2015

Variations for Neurosarcoidosis

Expression for Neurosarcoidosis

Search GEO for disease gene expression data for Neurosarcoidosis.

Pathways for Neurosarcoidosis

GO Terms for Neurosarcoidosis

Sources for Neurosarcoidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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