MCID: NRT011
MIFTS: 30

Neurotrophic Keratopathy malady

Categories: Eye diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Neurotrophic Keratopathy

Aliases & Descriptions for Neurotrophic Keratopathy:

Name: Neurotrophic Keratopathy 56
Neurotrophic Keratitis 56 69

Classifications:

Orphanet: 56  
Rare eye diseases


External Ids:

Orphanet 56 ORPHA137596
UMLS via Orphanet 70 C0339296
ICD10 via Orphanet 34 H16.2

Summaries for Neurotrophic Keratopathy

MalaCards based summary : Neurotrophic Keratopathy, also known as neurotrophic keratitis, is related to keratopathy and keratitis. An important gene associated with Neurotrophic Keratopathy is TAC1 (Tachykinin Precursor 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Ephedrine and Pseudoephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and brain.

Wikipedia : 71 Neurotrophic keratitis (NK) is a degenerative disease of the cornea caused by damage of the trigeminal... more...

Related Diseases for Neurotrophic Keratopathy

Diseases related to Neurotrophic Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
id Related Disease Score Top Affiliating Genes
1 keratopathy 10.5
2 keratitis 10.1
3 febrile seizures, familial, 10 9.9 TAC1 TACR1
4 mitochondrial dna depletion syndrome 3 9.9 TAC1 TACR1
5 microcephaly 13, primary, autosomal recessive 9.9 TAC1 TACR1
6 sweat gland cancer 9.9 TAC1 TACR1
7 neovascular glaucoma 9.8 TAC1 TACR1
8 neuropathy 9.8
9 hereditary sensory neuropathy 9.8
10 choroiditis 9.7
11 herpes zoster 9.7
12 amyloidosis 9.7
13 insulin-like growth factor i 9.7
14 lymphoma 9.7
15 anhidrosis 9.6
16 myopathy 9.6
17 pemphigus 9.6
18 cataract 9.6
19 limbal stem cell deficiency 9.6
20 pemphigus foliaceus 9.6
21 corneal disease 9.6
22 choanal atresia, unilateral 9.6 CD160 TAC1 TACR1

Graphical network of the top 20 diseases related to Neurotrophic Keratopathy:



Diseases related to Neurotrophic Keratopathy

Symptoms & Phenotypes for Neurotrophic Keratopathy

Drugs & Therapeutics for Neurotrophic Keratopathy

Drugs for Neurotrophic Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ephedrine Approved Phase 4,Phase 1,Phase 2 299-42-3 9294
2
Pseudoephedrine Approved Phase 4,Phase 1,Phase 2 90-82-4 7028
3 Mitogens Phase 4,Phase 1,Phase 2
4 Nasal Decongestants Phase 4,Phase 1,Phase 2
5 Tetrahydrozoline Phase 4,Phase 3,Phase 1,Phase 2
6 Ophthalmic Solutions Phase 4,Phase 3,Phase 1,Phase 2
7 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2
8 Vasoconstrictor Agents Phase 4,Phase 1,Phase 2
9 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2
10 Respiratory System Agents Phase 4,Phase 1,Phase 2
11 Autonomic Agents Phase 4,Phase 1,Phase 2
12 Lubricant Eye Drops Phase 4,Phase 1,Phase 2
13 Plasma-lyte 148 Phase 1, Phase 2
14 Anti-Infective Agents Phase 1, Phase 2
15 Protective Agents Phase 2
16 Antioxidants Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis Not yet recruiting NCT02707120 Phase 4
2 Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1 Recruiting NCT02600429 Phase 3
3 Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer Recruiting NCT01794312 Phase 3
4 Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. Completed NCT01756456 Phase 1, Phase 2
5 A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Recruiting NCT03084861 Phase 1, Phase 2
6 Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 Neurotrophic Keratitis Recruiting NCT02227147 Phase 2
7 Treatment of PED With AMT and Autologous Serum Completed NCT00238862
8 Miniinvasive Corneal Neurotization. A Pilot Study. Not yet recruiting NCT03037450

Search NIH Clinical Center for Neurotrophic Keratopathy

Genetic Tests for Neurotrophic Keratopathy

Anatomical Context for Neurotrophic Keratopathy

MalaCards organs/tissues related to Neurotrophic Keratopathy:

39
Eye, T Cells, Brain

Publications for Neurotrophic Keratopathy

Articles related to Neurotrophic Keratopathy:

(show all 34)
id Title Authors Year
1
Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases. ( 27450739 )
2016
2
Neurotrophic keratopathy secondary to trigeminal nerve aplasia in patient with Goldenhar syndrome. ( 26819096 )
2016
3
Etiologies, Quantitative Hypoesthesia, and Clinical Outcomes of Neurotrophic Keratopathy. ( 25828513 )
2015
4
Treatment of neurotrophic keratopathy with nicergoline. ( 25625360 )
2015
5
Potential New Modes of Treatment of Neurotrophic Keratopathy. ( 26448169 )
2015
6
Intraocular involvement of T-cell lymphoma presenting as inflammatory glaucoma, neurotrophic keratopathy, and choroidal detachment. ( 24909374 )
2014
7
Sclerokeratoplasty as the Therapy for Corneal Perforation due to Exposure and Neurotrophic Keratopathy. ( 24707423 )
2014
8
Neurotrophic keratopathy due to dorsolateral medullary infarction (Wallenberg syndrome): case report and literature review. ( 25472780 )
2014
9
Bilateral nerve alterations in a unilateral experimental neurotrophic keratopathy model: a lateral conjunctival approach for trigeminal axotomy. ( 23967133 )
2013
10
Scleral contact lenses as an alternative to tarsorrhaphy for the long-term management of combined exposure and neurotrophic keratopathy. ( 23073486 )
2013
11
Scleral contact lens management of bilateral exposure and neurotrophic keratopathy. ( 22902053 )
2012
12
A novel mouse model for neurotrophic keratopathy: trigeminal nerve stereotactic electrolysis through the brain. ( 21071731 )
2011
13
Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy. ( 19965821 )
2010
14
Neurotrophic keratopathy; its pathophysiology and treatment. ( 20376784 )
2010
15
Amyloidosis-associated neurotrophic keratopathy precipitated by overcorrected blepharoptosis. ( 19421037 )
2009
16
Corneal neurotization: a novel solution to neurotrophic keratopathy. ( 19116544 )
2009
17
Advances in treatment for neurotrophic keratopathy. ( 19537364 )
2009
18
Boston keratoprosthesis treatment of herpes zoster neurotrophic keratopathy. ( 18243928 )
2008
19
Open clinical study of eye-drops containing tetrapeptides derived from substance P and insulin-like growth factor-1 for treatment of persistent corneal epithelial defects associated with neurotrophic keratopathy. ( 18511539 )
2008
20
Persistent epithelial defects due to neurotrophic keratopathy treated with a substance p-derived peptide and insulin-like growth factor 1. ( 18158595 )
2007
21
Therapeutic options for the management of early neurotrophic keratopathy: a case report and review. ( 17000411 )
2006
22
Neurotrophic keratopathy and diabetes mellitus. ( 16215544 )
2006
23
New insights into the diagnosis and treatment of neurotrophic keratopathy. ( 17131013 )
2005
24
Treatment of neurotrophic keratopathy with nasal dilator strips. ( 16234466 )
2005
25
Autologous serum application in the treatment of neurotrophic keratopathy. ( 15177961 )
2004
26
Management of neurotrophic keratopathy. ( 16303512 )
2003
27
Restoration of corneal epithelial barrier function and wound healing by substance P and IGF-1 in rats with capsaicin-induced neurotrophic keratopathy. ( 12824234 )
2003
28
Effects of substance P and IGF-1 in corneal epithelial barrier function and wound healing in a rat model of neurotrophic keratopathy. ( 12939296 )
2003
29
Neurotrophic keratopathy. ( 11352446 )
2001
30
Bilateral neurotrophic keratopathy complicating Vidian neurectomy. ( 11438063 )
2001
31
Management of neurotrophic keratopathy. ( 10621535 )
1999
32
Direct observation of corneal nerve fibres in neurotrophic keratopathy by confocal biomicroscopy. ( 10560682 )
1999
33
Treatment of neurotrophic keratopathy with substance-P-derived peptide (FGLM) and insulin-like growth factor I. ( 9635953 )
1998
34
[Neurotrophic keratopathy--studies on substance P and the clinical significance of corneal sensation]. ( 9436358 )
1997

Variations for Neurotrophic Keratopathy

Expression for Neurotrophic Keratopathy

Search GEO for disease gene expression data for Neurotrophic Keratopathy.

Pathways for Neurotrophic Keratopathy

Pathways related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 TAC1 TACR1
2 11.17 TAC1 TACR1
3 9.47 TAC1 TACR1

GO Terms for Neurotrophic Keratopathy

Biological processes related to Neurotrophic Keratopathy according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.6 TAC1 TACR1
2 chemical synaptic transmission GO:0007268 9.59 TAC1 TACR1
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.58 TAC1 TACR1
4 regulation of blood pressure GO:0008217 9.58 TAC1 TACR1
5 response to hormone GO:0009725 9.57 TAC1 TACR1
6 sensory perception of pain GO:0019233 9.56 TAC1 TACR1
7 positive regulation of stress fiber assembly GO:0051496 9.55 TAC1 TACR1
8 positive regulation of epithelial cell migration GO:0010634 9.54 TAC1 TACR1
9 long-term memory GO:0007616 9.52 TAC1 TACR1
10 response to morphine GO:0043278 9.51 TAC1 TACR1
11 associative learning GO:0008306 9.49 TAC1 TACR1
12 response to pain GO:0048265 9.48 TAC1 TACR1
13 positive regulation of ossification GO:0045778 9.46 TAC1 TACR1
14 positive regulation of renal sodium excretion GO:0035815 9.43 TAC1 TACR1
15 positive regulation of synaptic transmission, GABAergic GO:0032230 9.4 TAC1 TACR1
16 positive regulation of lymphocyte proliferation GO:0050671 9.37 TAC1 TACR1
17 tachykinin receptor signaling pathway GO:0007217 9.32 TAC1 TACR1
18 positive regulation of action potential GO:0045760 9.26 TAC1 TACR1
19 positive regulation of synaptic transmission, cholinergic GO:0032224 9.16 TAC1 TACR1
20 positive regulation of saliva secretion GO:0046878 8.96 TAC1 TACR1
21 detection of abiotic stimulus GO:0009582 8.62 TAC1 TACR1

Sources for Neurotrophic Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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