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MCID: NTR004

Neutropenia malady
15 drugs, 180 genes, 14 tissues, 944 related diseases, 25 phenotypes, 550 articles, clinical trials.

Summaries for Neutropenia

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2CDC, 44Wikipedia, 22MalaCards
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CDC: People receiving chemotherapy are at risk for developing an infection when their white blood cell count is low. White blood cells are the body's main defense against infection. This condition, called neutropenia, is common after receiving chemotherapy. For patients with this condition, any infection can become serious quickly.2

MalaCards: Neutropenia is related to severe congenital neutropenia and cyclic hematopoiesis. An important gene associated with Neutropenia is ELANE (elastase, neutrophil expressed), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Jak-STAT signaling pathway. The drugs amphotericin b and ciprofloxacin and the compounds gp 130 and filgrastim have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia: Neutropenia, from Latin prefix neutro- (neither, for neutral staining) and Greek suffix -πενία...44 more...

Aliases & Descriptions for Neutropenia

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2CDC, 6Disease Ontology, 7diseasecard, 17Genetics Home Reference, 8DISEASES, 32Novoseek , 43UMLS, 19ICD9CM, 40SNOMED-CT, 24MeSH
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Aliases & Descriptions:

neutropenia 6 7 17 8 32 43

Related Diseases for Neutropenia

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13GeneCards, 14GeneDecks
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Diseases related to neutropenia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 941)
idRelated DiseaseScoreTop Affiliating Genes
1severe congenital neutropenia38.0IL3, ELANE, CSF2, CSF3, CSF3R
2cyclic hematopoiesis34.6IL3, ELANE, CSF1, CSF2, CSF3
3hodgkin's lymphoma33.1BLZF1, BCL2, JAK2, CD40, GZMB, IL1RN
4felty's syndrome32.2B3GAT1, IL10, IL3, IL8, CSF2, CSF3
5non-hodgkin lymphoma31.9KITLG, BIRC5, BCL2, JAK2, CD14, CD34
6glycogen storage disease31.1CLIC1, ITGAM, IL8, F3, ALB, HNF1A
7myelokathexis30.6G6PC3, CXCL12, CXCR4, CSF2, CSF3
8sepsis30.5CD14, IL10, TNF, LTA
9acute lymphoblastic leukemia30.3KITLG, BTK, BCL2, LEF1, UGT1A1, MPL
10myelodysplastic syndrome29.9KITLG, BIRC5, MPL, MPO, JAK2, CD34
11arthritis29.1IL1A, IL1B, IL6, IL8, TNF, TNFRSF1A
12breast cancer28.9BCL2, XRCC3, IL10, IL1B, IL6, IL8
13aplastic anemia28.8KITLG, SBDS, MPL, CD34, GZMB, IL11
14agammaglobulinemia28.7WAS, BTK, B3GAT1, CD79A, CD40LG, CD40
15large granular lymphocyte leukemia28.7BCL2, IL10, IL6, IL8, FASLG, FAS
16rheumatoid arthritis28.4CD40, IL10, IL1B, IL1RN, HLA-DQA1, HLA-DRB1
17primary immunodeficiency disease28.1BLZF1, CD40LG, CD40, FCGR3A, FCGR3B, STAT3
18wiskott-aldrich syndrome27.9WAS, BTK, BLZF1, CD40LG, INPP5D, IL11
19cellulitis27.8LACTB, IL1R1, IL3, FAS, CAMP, TNF
20periodontitis27.6LBP, MPO, CD14, FCGR3A, IL10, IL1A
21immunodeficiency27.6WAS, BTK, LMOD1, BLZF1, CISH, CD79A
22cheilitis27.5MPO, ERCC1, TNF, STAT3, CSF2
23vascular disease27.4NAMPT, CISH, ITGAM, F3, HTR3A, DYT10
24kaposi's sarcoma27.4CD14, CD34, CD9, IL6, IFNA1, IFNA2
25b-cell lymphomas27.3BTK, BLZF1, BIRC5, CLU, BCL2, JAK2
26chronic lymphocytic leukemia27.1BLZF1, BIRC5, BCL2, LEF1, JAK2, CD40LG
27t-cell leukemia27.0BLZF1, BIRC5, BCL2, CD40, ITGAL, IL1A
28ankylosing spondylitis27.0CD79A, CD40LG, IL1R1, IL1RN, TNF, TNFRSF1A
29hemophagocytic lymphohistiocytosis26.9RAB27A, GZMB, IL8, AP3B1, FAS, GPT
30acute myeloid leukemia26.4KITLG, RAC2, LIF, BLZF1, BIRC5, BCL2
31klebsiella26.4LACTB, MPO, CD79A, CD40LG, IL1B, IL1R1
32hepatitis26.3GZMB, GUSB, FASLG, FAS, GPT, IFNA1
33periodontal disease26.2CD79A, CD14, GUSB, IL11, IL1A, IL1B
34systemic lupus erythematosus25.8BLZF1, CLU, MPL, MPO, CD79A, CD40LG
35tuberculosis25.7CISH, IL10, IL1B, IL1RN, MBL2, IFNG
36myeloid leukemia25.3KITLG, RAC2, LIF, BLZF1, BIRC5, BCL2
37leukopenia24.9UGT1A1, MPO, CD79A, ITGAL, ITGAM, GUSB
38lymphoblastic leukemia24.9KITLG, BTK, BIRC5, BCL2, LEF1, UGT1A1
39papilloma24.8BIRC5, BCL2, S100B, GUSB, IFNA2, IFNB1
40septic shock24.8LIF, LBP, LACTB, CD14, ITGAM, FCGR1A
41renal cell carcinoma24.7BIRC5, CLU, UMPS, LACTB, CD40, CD9
42anemia24.6KITLG, NAMPT, LIF, BLZF1, CLU, CLIC1
43arthropathy24.6KITLG, CD79A, IL10, IL1B, IL1R1, IL1RN
44hepatitis c24.5CISH, CD40LG, IL10, FAS, GPT, IFNA1
45hematopoiesis24.4KITLG, LIF, BIRC5, BCL2, LEF1, CEBPE
46respiratory failure24.4ITGAM, IL10, IL1B, IL1R1, IL1RN, IL3
47leukemia24.2RECQL4, KITLG, BTK, NAMPT, RAC2, LIF
48peripheral neuropathy24.2LIF, MPO, CD40LG, CDAN1, IL10, IL3
49hyperthyroidism24.2KITLG, NAMPT, LMOD1, MPO, CD79A, CD40
50systemic lupus erythematosus, association with23.8CD40LG, ITGAM, FCGR2A, FCGR3A, FCGR3B, IL10

Graphical network of the top 20 diseases related to neutropenia:



Graphical network of diseases related to neutropenia

Clinical Features for Neutropenia

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Drugs & Therapeutics for Neutropenia

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS/NDF-RT:

43 28 amphotericin b, amphotericin b cholesteryl sulfate, amphotericin b lipid complex, amphotericin b liposome, cefepime, cefepime hydrochloride, ceftazidime, ciprofloxacin, ciprofloxacin hydrochloride, filgrastim, globulin,immune (iv), itraconazole, meropenem, vancomycin, vancomycin hydrochloride

Genetic Tests for Neutropenia

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Anatomical Context for Neutropenia

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22MalaCards
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MalaCards organs/tissues related to neutropenia:

22
Bone marrow, Whole blood, Brain, Kidney, Liver, Lung, Pancreas, Breast, Skin, Myeloid, Nk cells, T cells, B lymphoblasts, B cells

Phenotypes for genes affiliated with Neutropenia

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25MGI
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MGI Mouse Phenotypes related to neutropenia:

25 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.3INPP5D, AP3B1, CALCA, TRD@, PTPN6, LYST
2hematopoietic system phenotypeMP:000539710.2CSF3, CSF3R, SLC37A4, C5AR1, HAX1, EPO
3endocrine/exocrine gland phenotypeMP:00053799.9ERCC1, PTPN6, LTA, G6PC3, AFP, IFNG
4embryogenesis phenotypeMP:00053809.2PTPN11, EGFR, GFI1B, PROCR, CXCR4, CSF2
5adipose tissue phenotypeMP:00053759.1TNF, TNFRSF1A, TNFRSF1B, PTPN11, EGFR, TLR4
6nervous system phenotypeMP:00036318.8CXCL10, PROC, STAT3, TGFB1, TLR4, GFI1
7liver/biliary system phenotypeMP:00053708.7IL6, IFNG, HNF1A, TRD@, TRB@, NR0B2
8normal phenotypeMP:00028738.6G6PC, ELANE, NR0B2, PTPN11, PTPN3, TRB@
9pigmentation phenotypeMP:00011868.5PTPN11, PTPN6, EGFR, TLR4, SLC45A2, CP
10limbs/digits/tail phenotypeMP:00053718.5ERBB2, TNFRSF1A, PTPN6, LTA, EGFR, TLR4
11skeleton phenotypeMP:00053908.3FCGR1A, IL1R1, IL6, FAS, IFNB1, ALOX5
12digestive/alimentary phenotypeMP:00053818.3ERBB2, TRD@, TRG@, TRB@, PTPN6, NR0B2
13growth/size phenotypeMP:00053788.0G6PC3, G6PC, EGFR, LTA, NR0B2, PTPN6
14mortality/agingMP:00107687.8HAX1, EPOR, AFP, GATA1, C5AR1, CEBPE
15integument phenotypeMP:00107717.6RECQL4, KITLG, PCCA, BTK, RAB27A, LLGL2
16reproductive system phenotypeMP:00053897.5TLR4, NR0B2, PTPN6, PTPN11, TNFRSF1A, TNF
17tumorigenesisMP:00020067.4RECQL4, WAS, KITLG, BTK, BCL2, JAK2
18vision/eye phenotypeMP:00053916.9LTA, PTPN11, TNFRSF1B, TNFRSF1A, TNF, ERCC2
19behavior/neurological phenotypeMP:00053866.8TLR4, GFI1, G6PC, ABCB1, LTA, TNFRSF1B
20cellular phenotypeMP:00053845.6ABCB1, NKX6-2, PECAM1, LYST, AAAS, HAX1
21cardiovascular system phenotypeMP:0005385INFTGFB1, TLR4, GFI1B, ABCB1, EGFR, LTA
22immune system phenotypeMP:0005387INFGATA1, EPOR, RECQL4, INPP5D, FCGR1A, IL6
23muscle phenotypeMP:0005369INFTNF, TNFRSF1A, TNFRSF1B, PTPN11, EGFR, TGFB1
24homeostasis/metabolism phenotypeMP:0005376INFCD79A, CD14, CD40LG, CD34, CD40, ITGAL
25renal/urinary system phenotypeMP:0005367INFEGFR, ABCC2, G6PC, TLR8, CXCR4, SLC37A4

Publications for genes affiliated with Neutropenia

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35PubMed
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Articles related to neutropenia:

(show top 50)    (show all 550)
idTitleAuthorsYearAffiliating Genes
1Genetic etiologies of severe congenital neutropenia. (21206270)Boztug K.... Klein C.2011ELANE, HAX1, G6PC3
2Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for p henotype determination by modifying genes. (20582973)Newburger P.E.... Boxer L.A.2010ELANE
3A syndrome with congenital neutropenia and mutations in G6PC3. (19118303)Boztug K.... Klein C.2009G6PC3
4The -509C/T polymorphism of transforming growth facto r-beta1 is associated with increased risk for development of chronic idiopathic neutropenia. (19614955)Eliopoulos D.G.... Papadaki H.A.2009TGFB1, TNF, FASLG
5Is pegfilgrastim safe and effective in congenital neu tropenia? An analysis of the French Severe Chronic Neutropenia registry. (19618456)Beaupain B.... Donadieu J.2009CSF3
6A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene. (19006568)Beel K.... Vandenberghe P.2009WAS
7XM02, the first granulocyte colony-stimulating factor biosimilar, is safe and effective in reducing the duration of severe neutropenia and incidence of febrile neutropenia in patients with non-Hodgkin lymphoma receiving chemotherapy. (19347726)Engert A.... Del Giglio A.2009CSF3
8G-CSF in Peg-IFN induced neutropenia in liver transpl anted patients with HCV recurrence. (19916175)Lodato F.... Mazzella G.2009CSF3
9Safety and efficacy study of the recombinant granulo cyte colony-stimulating factor for prevention of neutropenia and neutropenia-re lated complications in women with metastatic breast cancer receiving docetaxel/ doxorubicin (19773618)Liutkauskiene S.... Fokas V.2009CSF3
10Neutropenia occurrence and predictors of reduced chemotherapy delivery: results from the INC-EU prospective observational European neutropenia study. (18351398)Pettengell R.... Jackisch C.2008CSF2
11Chronic idiopathic neutropenias and severe congenital neutropenia. (18043240)Palmblad J.... Papadaki H.A.2008TNF, ELANE, HAX1
12Prediction of outcome in cancer patients with febrile neutropenia: comparison of the Multinational Association of Supportive Care in Cancer risk-index score with procalcitonin, C-reactive protein, serum amyloid A, and interleukins-1beta, -6, -8 and -10. (17944761)Uys A.... Anderson R.2007IL6
13G-CSF treatment of severe congenital neutropenia reve rses neutropenia but does not correct the underlying functional deficiency of t he neutrophil in defending against microorganisms. (17311988)Donini M.... Badolato R.2007CSF3
14Genetic heterogeneity in severe congenital neutropenia: how many aberrant pathways can kill a neutrophil? (17989524)SchAoffer A.A.... Klein C.2007ELANE
15Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia. (16391909)Papadaki H.A.... Eliopoulos G.D.2006KITLG
16The Severe Chronic Neutropenia International Registry: 10-Year Follow-up Report. (18632498)Dale D.C.... Welte K.2006ELANE
17A case of neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-1a (HNA-1a) antibody. (16614528)Han T.H.... Han K.S.2006CD177
18Analysis of risk factors for myelodysplasias, leukemias and death from infection among patients with congenital neutropenia. Experience of the French Severe Chronic Neutropenia Study Group. (15642668)Donadieu J.... Chomienne C.2005CSF3
19Clericuzio type poikiloderma with neutropenia is distinct from Rothmund-Thomson syndrome. (15558713)Van Hove J.L.... Boogaerts M.2005RECQL4
20A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia. (16079102)Sera Y.... Kobayashi M.2005ELANE
21A mathematical model of hematopoiesis: II. Cyclical neutropenia. (15975606)Colijn C.... Mackey M.C.2005CSF3
22Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register. (14962902)Bellanne-Chantelot C.... Donadieu J.2004ELANE
23Cellular and molecular abnormalities in severe congenital neutropenia predisposing to leukemia. (12763135)Aprikyan A.A.... Dale D.C.2003ELANE
24High risk febrile neutropenia in acute leukemia. The experience of a public hospital. National Program of Antineoplastic Drugs in A dult, Hospital del Salvador, 1991-2001 (14635589)Puga B.... Toro P.2003IL3
25Molecular nature of antigens implicated in immune neutropenias. (12430890)Bux J.2002CD177
26Endogenous granulocyte colony-stimulating factor (G-C SF) levels in chemotherapy-induced neutropenia and in neutropenia related with primary diseases. (12636092)Kavgaci H.... Yavuz M.2002CSF2, CSF3
27Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia. (12091371)Ancliff P.J.... Linch D.C.2002ELANE
28Increased frequency of HLA-DRB1*1302 haplotype in patients with nonimmune chronic idiopathic neutropenia of adults. (11202431)Papadaki H.A.... Stavropoulos-Giokas C.2001HLA-DRB1
29Prophylactic administration of granulocyte colony-stimulating factor when monocytopenia appears lessens neutropenia caused by chemotherapy for lung cancer. (10857893)Oshita F.... Noda K.2000CSF3
30Neutropenia, neutrophil dysfunction, and bacterial infection in patients with human immunodeficiency virus disease: the role of granulocyte colony-stimulating factor. (10671324)Kuritzkes D.R.2000CSF3
31Combined corticosteroid/granulocyte colony-stimulating factor (G-CSF) therapy in the treatment of severe congenital neutropenia unresponsive to G-CSF: Activated glucocorticoid receptors synergize with G-CSF signals. (11146160)Dror Y.... Freedman M.H.2000STAT5A, CSF3
32A patient with cyclic neutropenia complicated by severe persistent neutropenia successfully delivered a healthy baby. (10939543)Abe T.... Matsumoto T.2000CSF3
33Treatment of severe neutropenia due to Felty's syndrome or systemic lupus erythematosus with granulocyte colony-stimulating factor. (10553980)Hellmich B.... Gross W.L.1999CSF3
34Severe neutropenia as an adverse effect of methimazol e in the treatment of hyperthyroidism. (10476084)Ryan J.A.1999CSF3
35SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 are dramatically increased at the protein level in neutrophils from patients with severe congenital neutropenia (Kostmann's syndrome). (10378893)Tidow N.... Welte K.1999PTPN11, NR0B2, PTPN3
36Transient neutropenia may be a risk of treating preterm neonates with high doses of recombinant erythropoietin. (9625350)Latini G.... Rosati E.1998EPO
37Clinical relevance of point mutations in the cytoplasmic domain of the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia. (9116280)Tidow N.... Welte K.1997CSF3, CSF3R
38Induction of granulocyte colony-stimulating factor by acute febrile infection but not by neutropenia in HIV-seropositive individuals. (9170417)Mauss S.... Jablonowski H.1997CSF3
39Severe congenital neutropenia patients with point mutations in the granulocyte colony-stimulating factor (G-CSF) receptor mRNA express a normal G-CSF receptor protein. (9326253)Kasper B.... Welte K.1997CSF3
40Treatment of neutropenia in HIV infection with hematopoietic growth factors (8701065)Moreno GarcA-a M.... FernA!ndez GonzA!lez F.1996IL3
41Granulocyte colony-stimulating factor treatment of cyclic neutropenia with recurrent oral aphthae. (8915334)Fink-Puches R.... Kerl H.1996CSF3
42The protein tyrosine kinase JAK2 is activated in neutrophils from patients with severe congenital neutropenia. (8541539)Rauprich P.... Welte K.1995JAK2, CSF3
43G-CSF in the long-term treatment of cyclic neutropenia and chronic idiopathic neutropenia in adult patients. (8589368)Heussner P.... Freund M.1995CSF3
44Cyclic neutropenia and treatment with granulocyte colony-stimulating factor (G-CSF) (7885503)Anninga J.K.... Weening R.S.1995CSF3
45Antibiotic strategy in orofacial/head and neck infect ions in severe neutropenia. (8015798)Barrett A.P.... Schifter M.1994LACTB
46Anemia and neutropenia in elderly patients caused by copper deficiency for long-term enteral nutrition (7823395)Banno S.... Yamamoto T.1994CP
47Quality of life of patients with severe chronic neutropenia receiving long-term treatment with granulocyte colony-stimulating factor. (7688828)Jones E.A.... Dale D.C.1993CSF3
48Expression of receptors for granulocyte colony-stimulating factor on neutrophils from patients with severe congenital neutropenia and cyclic neutropenia. (1371412)Kyas U.... Welte K.1992CSF3
49Differential effects of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in children with severe congenital neutropenia. (1689595)Welte K.... Riehm H.1990CSF2, CSF3
50Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia. (1978690)Huizinga T.W.... von dem Borne A.E.1990FCGR3A

Expression for genes affiliated with Neutropenia

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Neutropenia

Pathways for genes affiliated with Neutropenia

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36QIAGEN, 20KEGG, 37R&D Systems, 41Thomson Reuters, 3Cell Signaling Technology, 10EMD Millipore, 34PharmGKB
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Pathways related to neutropenia according to GeneDecks:

(show top 50)    (show all 159)
idPathwayScoreTop Affiliating Genes
1RAR-Gamma-RXR-Alpha Degradation3610.9BTK, LIF, IL11, CSF3, CSF2, CSF1
2Jak-STAT signaling pathway2010.7EPO, EPOR, CSF3R, STAT5A, STAT3, CISH
3IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types3710.7CCL3, GZMB, FASLG, TNFRSF1A, CSF2, BCL2
4Natural killer cell mediated cytotoxicity2010.7PTPN6, PTPN11, TNFRSF10C, TNF, IFNG, IFNA2
5Development_Thrombopoetin signaling via JAK-STAT pathway4110.7STAT5A, THPO, CRP, CISH, MPL, JAK2
6Lymphocyte Signaling310.7CD34, FASLG, PTPN6, GFI1B, GATA1, INPP5D
7Development Thrombopoetin signaling via JAK-STAT pathway1010.6PTPN6, PTPN11, CRP, STAT3, STAT5A, JAK2
8Bacterial infections in CF airways4110.6LBP, IL1R1
9IL-6 Pathway3610.5BTK, IL10, IL11, IL3, IL7, CCL3
10Drug metabolism - other enzymes2010.4DPYD, UGT1A1, CYP3A4, CYP3A5, GUSB, CES2
11Graft-versus-host disease2010.3HLA-DQA1, FASLG, IL1A
12Akt Signaling3610.2BTK, LIF, ITGAL, ITGAM, IL10, IL11
13PGC1Alpha Pathway3610.2IL3, IL1B, IL1R1, IL11, BCL2, BTK
14Hematopoietic cell lineage2010.2EPOR, EPO, CSF3R, CSF3, CSF2, CSF1
15Immune response_Bacterial infections in normal airways4110.1IFNG, LBP, CD14, IL1B, IL1R1
16Irinotecan Pathway, Pharmacokinetics3410.1SLCO1B1, ABCG2, ABCC2, ABCC1, ABCB1, CYP3A5
17Mycophenolic acid Pathway, Pharmacokinetics3410.1SLCO1B1, ABCG2, ABCC2, ABCB1, CYP3A4, CES2
18Irinotecan Pathway, Pharmacodynamics349.9UGT1A1, UGT1A6, ABCB1, ABCC2, CES2, TOP1
19Toll-like receptor signaling pathway209.9TLR8, IFNA2, IFNB1, TLR4, TNF, IFNA1
20Staphylococcus aureus infection209.8ITGAL, ITGAM, MASP2, MBL2, IL10, FCGR3B
21PEDF Induced Signaling369.8CSF3, CSF2, CSF1, CXCL12, CXCL10, LTA
22STAT3 Pathway369.8TNFRSF1A, CSF2, CSF1, CXCR4, CXCL12, CXCL10
23all-trans-Retinoic Acid Signaling in Brain369.8CSF3, IL1B, IL3, IL6, IL7, IL8
24Rho Family GTPases369.6KITLG, BTK, RAC2, EPOR, CSF3, CSF2
25Osteoclast differentiation209.5FCGR1A, BTK, FCGR2A, FCGR3A, FCGR3B, IL1A
26MIF Regulation of Innate Immune Cells369.5TLR4, CXCL10, CXCL12, CSF1, CSF2, CSF3
27MIF Mediated Glucocorticoid Regulation369.5CXCL12, CSF1, CSF2, CSF3, CXCL10, LTA
28Cytokine Network369.3IL10, IL1A, IFNG, IFNB1, IFNA2, IFNA1
29Glucocorticoid Receptor Signaling369.2IL1A, IL11, TGFB1, IL1B, IL10, IL8
30Antioxidant Action of Vitamin-C369.1KITLG, TNF, TNFRSF10C, TNFRSF1A, TNFRSF1B, LTA
31Molecular Mechanisms of Cancer369.1KITLG, BTK, RAC2, LIF, BCL2, ITGAL
32Tec Kinases Signaling369.0EPOR, CXCL12, STAT5A, STAT3, TGFB1, THPO
33Type I diabetes mellitus208.9FASLG, LTA, HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG
34Malaria208.9TGFB1, TLR4, DARC, TNF, IFNG, IL8
35TGF-Beta Pathway368.9IL1R1, IL1B, THPO, IL11, BCL2, IL8
36Allograft rejection208.8GZMB, IFNG, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF
37MAPK Family Pathway368.8IL3, IL1R1, IL1B, IL11, IL6, IL7
38ERK Signaling368.8BTK, KITLG, ITGAL, IL6, EPOR, CXCL12
39Autoimmune thyroid disease208.8FASLG, FAS, HLA-DQA1, HLA-DRB1, HLA-DQB1, IFNA1
40Rheumatoid arthritis208.7CCL3, IL8, IL6, IL1B, IL1A, IL11
41Influenza A208.6IFNB1, IFNG, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF
42Leishmaniasis208.5IL1A, IL10, FCGR3B, FCGR3A, FCGR2A, FCGR1A
43PAK Pathway368.4LTA, CSF3, CSF2, CSF1, CXCL12, CXCL10
44NF-KappaB (p50-p65) Pathway368.4CXCL12, TGFB1, TLR8, TLR4, EGFR, LTA
45JAK-STAT Pathway368.4IFNA2, IFNA1, CCL3, IL8, IL7, IL6
46Cytokine-cytokine receptor interaction208.3CSF1, EPOR, EPO, CSF3R, CSF3, CSF2
47Endothelin-1 Signaling Pathway368.1CSF1, CSF3, EPOR, CXCL12, CXCL10, EGFR
48p38 Signaling367.8IL1B, IL7, CSF1, CXCR4, CXCL12, CXCL10
49Toxoplasmosis207.8CD40LG, CD40, STAT3, TGFB1, TLR4, IL10
50Tuberculosis207.5FCGR3A, FCGR2A, FCGR1A, ITGAM, CD14, JAK2

Compounds for genes affiliated with Neutropenia

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32Novoseek , 9DrugBank, 42Tocris Bioscience, 18HMDB, 34PharmGKB
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Compounds related to neutropenia according to GeneDecks:

(show top 50)    (show all 570)
idCompoundScoreTop Affiliating Genes
1gp 13032 11.1BTK, LIF, CISH, MPL, JAK2, IL1R1
2filgrastim32 9 9 12.9KITLG, LIF, ITGAM, IL11, IL1RN, IL3
3phosphoinositide32 10.6BTK, RAC2, BIRC5, CISH, JAK2, CD9
4ifosfamide32 9 9 12.5IL11, IL3, IFNA2, ERCC1, CYP3A4, CYP2B6
5cytochalasin d32 42 11.5WAS, KITLG, JAK2, ITGAL, FCGR1A, FCGR2A
6phosphatidylserine32 9 9 12.5BCL2, CD79A, CD14, GZMB, FCGR3B, MBL2
712-o-tetradecanoylphorbol 13-acetate32 10.3LIF, JAK2, CD34, CD9, ITGAM, GZMB
8endotoxin32 10.2LIF, LBP, JAK2, CD14, CD40, ITGAL
9rapamycin32 42 11.0WAS, KITLG, JAK2, GZMB, IL1R1, IFNG
10hyaluronic acid32 18 10.9ITGAL, GZMB, IL11, FASLG, GPT, RHOA
11latex32 9.9WAS, KITLG, LIF, BLZF1, CD14, CD9
12heparin32 9 18 9 12.8KITLG, LIF, LBP, B3GAT1, MPO, CD79A
13melphalan32 9 9 11.8BIRC5, XRCC3, CD79A, IFNA1, IFNA2, IFNG
14aspartate32 9.7UMPS, LBP, S100B, CEACAM3, CD14, CD40LG
15polysulfone32 9.6LBP, CD14, ITGAM, IL1B, IL1R1, IL1RN
16sulfasalazine32 9 9 11.5MPO, CD79A, CD40LG, IL1A, IL1B, IL1R1
17ribavirin32 34 9 9 12.3CD40LG, IL10, IL3, MBL2, CCL3, GPT
18troglitazone32 42 9 9 12.3BIRC5, BCL2, UGT1A1, UGT1A6, UGT1A9, IL11
19gm-csf32 9.3KITLG, LIF, CD14, IL10, IL11, IL1A
20vinblastine32 9 9 11.3BIRC5, BCL2, ITGAL, IL3, IFNA1, IFNA2
21histamine32 18 10.1KITLG, BTK, B3GAT1, MPO, CD79A, CD14
22arginine32 9.1BTK, LIF, BLZF1, UGT1A1, B3GAT1, S100B
23iron32 18 10.1KITLG, BLZF1, S100B, MPL, MPO, CDAN1
24tgf beta132 8.9KITLG, LIF, BLZF1, IL10, IL11, IL1B
25zidovudine32 9 9 10.8KITLG, UGT1A7, UGT1A9, CD9, GUSB, IL10
26phosphatidylinositol32 8.8WAS, KITLG, BTK, NAMPT, RAC2, LIF
27etanercept32 9 9 10.6FCGR1A, FCGR2A, FCGR3A, FCGR3B, IL10, IL11
28ccl332 8.5IL10, IL11, IL1A, IL1B, IL1R1, IL6
29pdtc32 8.3BIRC5, BCL2, CD40, IL1A, IL1B, IL6
30epinephrine32 9 18 9 11.3KITLG, JAK2, CD79A, ITGAM, FCGR2A, IL11
31tacrolimus32 34 9 9 11.2UGT1A9, CD79A, CD40, ITGAL, GZMB, IL10
32vinorelbine32 9 9 10.2ERCC2, ERBB2, ERCC1, CYP3A4, KLK3, EGFR
33taxane32 8.1BIRC5, BCL2, ERBB2, KLK3, EGFR, ABCB1
34alanine32 7.9KITLG, BLZF1, BIRC5, LEF1, UGT1A1, LBP
35cyclosporin a32 42 8.8KITLG, LIF, BLZF1, S100B, JAK2, CD14
36thyroxine32 18 8.7LMOD1, UGT1A1, CEACAM3, CD79A, CD40LG, IL10
37curcumin32 7.7BIRC5, BCL2, UGT1A1, UGT1A7, JAK2, IL1A
38hydrocortisone32 9 9 9.3KITLG, LIF, CD14, CD40, IL10, IL1A
39methotrexate32 34 42 9 9 10.8KITLG, BIRC5, CEACAM3, CD79A, CD40, FCGR3A
40glutamate32 INFBLZF1, , JAK2, CD79A, CD40, ITGAL
41fibrinogen32 INFBTK, NAMPT, LIF, , LBP, CEACAM3
42atp32 INFWAS, PCCA, BTK, LIF, BLZF1, BIRC5
43paclitaxel32 34 9 9 INFKITLG, LIF, BIRC5, , BCL2, S100B
44doxorubicin32 34 9 9 INFKITLG, , CEACAM3, CD40LG, CD40, ITGAL
45cysteine32 INFBTK, LMOD1, LIF, BLZF1, , CLIC1
46cisplatin32 34 9 9 INFKITLG, LIF, BLZF1, BIRC5, , BCL2
47dexamethasone32 42 34 9 9 INFKITLG, NAMPT, LMOD1, LIF, BIRC5,
48testosterone32 9 18 9 INFKITLG, LIF, BLZF1, BIRC5, , UGT1A1
49cholesterol32 9 18 9 INFKITLG, NAMPT, LIF, BLZF1, BIRC5,
50etoposide32 42 9 9 INFBIRC5, , BCL2, UGT1A1, S100B, ITGAL

GO Terms for genes affiliated with Neutropenia

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Sources:
12Gene Ontology
See all sources

Cellular components related to neutropenia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.0TLR4, EGFR, TNFRSF1B, TNFRSF1A, TNF, FAS
2external side of plasma membraneGO:0098978.7ANPEP, IFNG, HLA-DRB1, TNF, TLR4, CXCL10
3plasma membraneGO:0058866.1DARC, RHOA, EGFR, ABCB1, TNFRSF1B, TNFRSF1A
4extracellular regionGO:005576INFEPOR, KITLG, IL3, IL6, IL7, IL8
5extracellular spaceGO:005615INFIL1RN, IL3, IL6, IL7, IL8, FASLG

Biological processes related to neutropenia according to GeneDecks:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1leukocyte migrationGO:05090010.8PECAM1, PROC, ELANE, PTPN6, PTPN11, INPP5D
2drug metabolic processGO:01714410.7DCK, CYP2B6, CYP3A4, UGT1A9, UGT1A7, UGT1A1
3defense response to Gram-positive bacteriumGO:05083010.7C5AR1, LTA, TNF, CAMP, MBL2, IL6
4opsonizationGO:00822810.6CRP, PTX3, MBL2, LBP
5organ regenerationGO:03110010.5AFP, CXCL12, TGFB1, NR0B2, UGT1A1, LEF1
6positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.4GATA1, TLR4, IL6, IL3, IL11, JAK2
7acute-phase responseGO:00695310.4LBP, IL1RN, IL6, MBL2, CRP, STAT3
8positive regulation of cell proliferationGO:00828410.3EGFR, THPO, TGFB1, PRTN3, CXCL10, CSF1
9positive regulation of interleukin-8 biosynthetic processGO:04541610.3TNF, ELANE, TLR4, TLR8
10JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.3STAT5A, STAT3, PTPN6, JAK2, CISH
11positive regulation of tyrosine phosphorylation of Stat1 proteinGO:04251110.3LIF, CD40, IFNG, TNFRSF1A
12cellular component movementGO:00692810.2STAT3, IFNG, IL8, ARHGDIB, FPR1, ITGAL
13neutrophil chemotaxisGO:03059310.2C5AR1, CSF3R, IFNG, CCL3, IL8, IL1B
14defense response to virusGO:05160710.2LYST, CXCL10, TLR8, IFNG, IFNB1, IL6
15positive regulation of tumor necrosis factor productionGO:03276010.2TLR4, TNFRSF1A, IFNG, CCL3, CD14, JAK2
16humoral immune responseGO:00695910.1LTF, LTA, TNF, IFNG, IFNB1, IL7
17negative regulation of growth of symbiont in hostGO:04413010.0ELANE, LTA, TNF, CAMP, IFNG, MBL2
18B cell proliferationGO:04210010.0IFNB1, IL10, CD40, CD40LG, CD79A, BCL2
19response to lipopolysaccharideGO:03249610.0LTA, ELANE, TLR4, THPO, CXCL10, EPO
20positive regulation of peptidyl-serine phosphorylationGO:03313810.0TGFB1, TNF, IL6, IL11, BCL2, LIF
21lipopolysaccharide-mediated signaling pathwayGO:0316639.9TGFB1, TLR4, TNF, CCL3, IL1B, LBP
22interferon-gamma-mediated signaling pathwayGO:0603339.9PTPN6, PTPN11, HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG
23cellular response to lipopolysaccharideGO:0712229.8TLR4, GFI1, TNFRSF1B, IFNG, IL8, IL10
24positive regulation of interleukin-6 productionGO:0327559.8TLR4, TNF, IL6, IL1B, IL1A, LBP
25positive regulation of MAP kinase activityGO:0434069.8TGFB1, ELANE, EGFR, TNF, ERBB2, CD40
26immune responseGO:0069559.7HLA-DQA1, HLA-DQB1, HLA-DRB1, TLR4, PROCR, CXCL10
27cell proliferationGO:0082839.6ERCC1, PTPN6, EGFR, GFI1B, THPO, STAT3
28small molecule metabolic processGO:0442819.5TYMS, G6PC3, G6PC, ABCG2, ABCB1, DPYD
29positive regulation of nitric oxide biosynthetic processGO:0454299.5TLR4, EGFR, PTX3, TNF, IFNG, IL1B
30cell-cell signalingGO:0072679.5IFNA2, CALCA, LTA, CXCL10, GATA1, CCL3
31defense response to bacteriumGO:0427429.5LYST, TLR4, LTF, TNFRSF1A, CAMP, IFNG
32cytokine-mediated signaling pathwayGO:0192219.4HLA-DRB1, TNFRSF1A, PTPN11, PTPN6, STAT3, STAT5A
33signal transductionGO:0071659.4EGFR, LTA, TNFRSF10C, ERBB2, ANXA5, STAT3
34anti-apoptosisGO:0069169.4FAS, ANXA5, F3, TNF, EPO, IL1B
35positive regulation of MHC class II biosynthetic processGO:0453489.3TLR4, IFNG, IL10, CD40LG
36cell surface receptor signaling pathwayGO:0071669.3NPPB, CXCR1, CXCL10, EGFR, ERBB2, IFNG
37response to hypoxiaGO:0016669.3LTA, TLR4, TGFB1, CXCL12, CXCR4, NPPB
38apoptotic processGO:0069159.2CASP3, ERCC2, TNF, TNFRSF10C, TNFRSF1A, TNFRSF1B
39positive regulation of transcription from RNA polymerase II promoterGO:0459448.9ERCC2, TNF, TNFRSF1A, TLR4, TGFB1, STAT3
40inflammatory responseGO:0069548.7CD14, TNFRSF1B, PTX3, DARC, CRP, TLR8
41response to drugGO:0424938.6ABCC1, ABCG2, TOP1, TGFB1, STAT3, NPPB
42blood coagulationGO:007596INFPTPN6, PTPN11, ALB, F3, IFNB1, RHOA
43innate immune responseGO:045087INFCD14, IL1R1, MBL2, MASP2, IFNA2, IFNB1
44negative regulation of apoptotic processGO:043066INFTNF, EGFR, PROC, CXCL12, CSF2, EPO
45platelet activationGO:030168INFPECAM1, TGFB1, THPO, RHOA, ALB, IL6
46positive regulation of NF-kappaB transcription factor activityGO:051092INFTLR4, TNF, IL6, IL1B, CD40,

Molecular functions related to neutropenia according to GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.5FCGR1A, FCGR2A, FCGR3A, FCGR3B
2growth factor activityGO:0080839.7THPO, TGFB1, CXCL12, CSF1, CSF2, CSF3
3enzyme bindingGO:0198999.7CYP3A4, EGFR, TGFB1, PRTN3, CSF3, SLPI
4protein homodimerization activityGO:0428039.6NR0B2, CRP, ABCG2, TGFB1, DPYD, DCK
5cytokine activityGO:0051259.1CSF3, IFNA2, IFNB1, IFNG, TNF, LTA
6protein heterodimerization activityGO:0469828.9ITGAL, HNF1A, ERBB2, EGFR, TGFB1, CEBPE
7protein bindingGO:005515INFCRP, RHOA, LTF, KLK3, EGFR, ABCB1

Sources for Neutropenia

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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