MCID: NTR004
MIFTS: 59

Neutropenia malady

Categories: Blood diseases, Genetic diseases, Rare diseases, Bone diseases, Immune diseases, Nephrological diseases

Aliases & Classifications for Neutropenia

Summaries for Neutropenia

CDC : 3 People receiving chemotherapy are at risk for developing an infection when their white blood cell count is low. White blood cells are the body’s main defense against infection. This condition, called neutropenia, is common after receiving chemotherapy. For patients with this condition, any infection can become serious quickly.

MalaCards based summary : Neutropenia, also known as leukopenia, is related to poikiloderma with neutropenia and severe congenital neutropenia. An important gene associated with Neutropenia is CSF3R (Colony Stimulating Factor 3 Receptor), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Lenograstim and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, myeloid and bone, and related phenotypes are hematopoietic system and immune system

Wikipedia : 71 Neutropenia or neutropaenia, is an abnormally low concentration of neutrophils (a type of white blood... more...

Related Diseases for Neutropenia

Diseases in the Neutropenia family:

Neutropenia, Severe Congenital 2, Autosomal Dominant Neutropenia, Severe Congenital, 5, Autosomal Recessive
Neutropenia, Severe Congenital 3, Autosomal Recessive Neutropenia, Severe Congenital, 6, Autosomal Recessive
Neutropenia, Severe Congenital 4, Autosomal Recessive Neutropenia, Severe Congenital 1, Autosomal Dominant
Severe Congenital Neutropenia Elane-Related Neutropenia
Neutropenia Chronic Familial Severe Congenital Neutropenia Autosomal Dominant
Gata1-Related Neutropenia Neutropenia, Severe Congenital 7, Autosomal Recessive

Diseases related to Neutropenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 327)
id Related Disease Score Top Affiliating Genes
1 poikiloderma with neutropenia 12.3
2 severe congenital neutropenia 12.3
3 neutropenia, cyclic 12.2
4 idiopathic neutropenia 12.2
5 neutropenia, severe congenital 3, autosomal recessive 12.1
6 3-methylglutaconic aciduria, type vii, with cataracts, neurologic involvement and neutropenia 12.1
7 neutropenia, severe congenital, 5, autosomal recessive 12.1
8 neutropenia, severe congenital 1, autosomal dominant 12.1
9 neutropenia, nonimmune chronic idiopathic, of adults 12.1
10 neutropenia, severe congenital, x-linked 12.0
11 neutropenia, severe congenital 4, autosomal recessive 12.0
12 anemia, x-linked, with/without neutropenia and/or platelet abnormalities 12.0
13 neutropenia, severe congenital, 6, autosomal recessive 12.0
14 neutropenia, severe congenital 2, autosomal dominant 12.0
15 neutropenia, severe congenital 7, autosomal recessive 12.0
16 transient neonatal neutropenia 11.9
17 neutropenia, alloimmune neonatal 11.9
18 elane-related neutropenia 11.9
19 barth syndrome 11.8
20 neutropenia chronic familial 11.7
21 severe congenital neutropenia autosomal dominant 11.7
22 neutropenia lethal congenital with eosinophilia 11.7
23 neutropenia monocytopenia deafness 11.7
24 felty syndrome 11.7
25 autosomal recessive severe congenital neutropenia due to csf3r deficiency 11.6
26 autosomal recessive severe congenital neutropenia due to cxcr2 deficiency 11.6
27 gata1-related neutropenia 11.6
28 onychotrichodysplasia and neutropenia 11.6
29 clpb deficiency 11.3
30 whim syndrome 11.3
31 hermansky-pudlak syndrome 2 11.2
32 glycogen storage disease ib 11.1
33 large granular lymphocyte leukemia 11.0
34 cohen syndrome 11.0
35 wiskott-aldrich syndrome 11.0
36 pearson syndrome 11.0
37 leukemia, acute lymphoblastic 10.8
38 ablepharon-macrostomia syndrome 10.7
39 lichtenstein syndrome 10.7
40 immunodeficiency due to defect in mapbp-interacting protein 10.6
41 propionicacidemia 10.6
42 ras-associated autoimmune leukoproliferative disorder 10.6
43 immunodeficiency, x-linked, with hyper-igm 10.6
44 immunodeficiency due to purine nucleoside phosphorylase deficiency 10.6
45 stenotrophomonas maltophilia infection 10.6
46 griscelli syndrome, type 2 10.6
47 autoimmune lymphoproliferative syndrome, type ii 10.6
48 thrombocytopenia, x-linked 10.6
49 3-methylglutaconic aciduria 8 10.6
50 immunodeficiency 50 10.6

Comorbidity relations with Neutropenia via Phenotypic Disease Network (PDN): (show all 50)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Leukemia Agammaglobulinemia, X-Linked 1
Aplastic Anemia Autoimmune Hemolytic Anemia
Bronchitis Chronic Kidney Failure
Colorectal Cancer Decubitus Ulcer
Deficiency Anemia Esophageal Cancer
Esophageal Candidiasis Esophagitis
Felty Syndrome Female Breast Cancer
Gastric Cancer, Somatic Heart Disease
Hepatic Encephalopathy Hydronephrosis
Hypersplenism Hypothyroidism
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1 Intestinal Obstruction
Iron Deficiency Anemia Leukemia, B-Cell, Chronic
Lymphoblastic Leukemia Main Bronchus Cancer
Megakaryocytic Leukemia Oral Candidiasis
Ovarian Cancer, Somatic Paralytic Ileus
Plasma Cell Neoplasm Pneumocystosis
Portal Hypertension Postinflammatory Pulmonary Fibrosis
Primary Immunodeficiency Disease Primary Thrombocytopenia
Protein-Energy Malnutrition Rectal Neoplasm
Respiratory Failure Rheumatoid Arthritis
Sideroblastic Anemia Systemic Lupus Erythematosus
Tn Polyagglutination Syndrome, Somatic Urinary Bladder Cancer
Waldenstrom Macroglobulinemia Wegener Granulomatosis

Graphical network of the top 20 diseases related to Neutropenia:



Diseases related to Neutropenia

Symptoms & Phenotypes for Neutropenia

MGI Mouse Phenotypes related to Neutropenia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CSF2 CSF3 CSF3R ELANE FCGR3B G6PC3
2 immune system MP:0005387 9.32 G6PC3 GFI1 HAX1 JAGN1 WAS CSF2

Drugs & Therapeutics for Neutropenia

Drugs for Neutropenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 519)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1 135968-09-1
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 124-94-7 31307
3
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 3081921 477468
4
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
5
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
6
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
7
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 23214-92-8 31703
8
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
9
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 137234-62-9 71616
10
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
11
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
12
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
13
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
14
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
15
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
16
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
17
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
18
Epirubicin Approved Phase 4,Phase 2,Phase 3,Phase 1 56420-45-2 41867
19
alemtuzumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 216503-57-0
20
Cisplatin Approved Phase 4,Phase 3,Phase 1,Phase 2 15663-27-1 84093 441203 2767
21
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
22
Piperacillin Approved Phase 4,Phase 2 66258-76-2 43672
23
Tazobactam Approved Phase 4,Phase 2 89786-04-9 123630
24
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 1 154361-50-9 60953
25
Pemetrexed Approved, Investigational Phase 4,Phase 2,Phase 1 150399-23-8, 137281-23-3 446556 60843
26
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
27
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
28
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
29
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2 84625-61-6 55283
30
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
31
Tobramycin Approved, Investigational Phase 4,Phase 3 32986-56-4 5496 36294
32
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1 159351-69-6 6442177
33
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53123-88-9 5284616 6436030 46835353
34
Tacrolimus Approved, Investigational Phase 4,Phase 1,Phase 2 104987-11-3 445643 439492
35
Imipenem Approved Phase 4 74431-23-5 104838
36
Teicoplanin Approved Phase 4 61036-62-2
37
Vancomycin Approved Phase 4,Phase 3,Phase 2 1404-90-6 441141 14969
38
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 171228-49-2 147912
39
Menthol Approved Phase 4 2216-51-5 16666
40
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
41
Diphenhydramine Approved Phase 4,Phase 3,Phase 2,Phase 1 58-73-1, 147-24-0 3100
42
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
43
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
44
Histamine Approved, Investigational Phase 4,Phase 2,Phase 1 75614-87-8, 51-45-6 774
45
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
46
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
47
Ondansetron Approved Phase 4,Phase 3,Phase 1 99614-02-5 4595
48
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
49
Promethazine Approved Phase 4,Phase 3,Phase 2,Phase 1 60-87-7 4927
50
Ranitidine Approved Phase 4 66357-59-3, 66357-35-5 3001055

Interventional clinical trials:

(show top 50) (show all 765)
id Name Status NCT ID Phase
1 Prevention of Neutropenia After Using G-CSF With TAC Chemotherapy Unknown status NCT01571518 Phase 4
2 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4
3 Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer Unknown status NCT00030758 Phase 4
4 Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda Unknown status NCT00674921 Phase 4
5 Pemetrexed Followed by Docetaxel or in Reverse Sequence Completed NCT01442909 Phase 4
6 Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma Completed NCT00969462 Phase 4
7 A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux Completed NCT00382343 Phase 4
8 Intensified Dosing of Cellcept (Mycophenolate Mofetil) in Kidney Transplantation Completed NCT00943228 Phase 4
9 A Study of Empirical Antifungal Therapy With Itraconazole Completed NCT01706562 Phase 4
10 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen Completed NCT01107756 Phase 4
11 Observational Study Investigating the Response Rate of Itraconazole Injection in Treating Immunocompromised Patients Completed NCT01060462 Phase 4
12 The Tobramycin Study Completed NCT00257790 Phase 4
13 FIRST - Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy Completed NCT00125723 Phase 4
14 Study Evaluating A Planned Transition From Tacrolimus To Sirolimus In Kidney Transplant Recipients Completed NCT00895583 Phase 4
15 Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia Completed NCT02213783 Phase 4
16 Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia Completed NCT01581333 Phase 4
17 Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients Completed NCT01401010 Phase 4
18 The Relationship of Defeverscence and Itraconazole Plasma Level Study in Immunocompromised Participants Completed NCT01021683 Phase 4
19 Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients Completed NCT00454272 Phase 4
20 Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115) Completed NCT00686543 Phase 4
21 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy to Prevent Neutropenia Completed NCT02805205 Phase 4
22 Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients Completed NCT01114165 Phase 4
23 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
24 Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer Completed NCT01649635 Phase 4
25 A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency Completed NCT01289847 Phase 4
26 Safety of Cotrimoxazole in HIV- and HAART-exposed Infants Completed NCT01086878 Phase 4
27 A Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis After Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer Completed NCT00277160 Phase 4
28 Neulasta® in Subjects With Advanced Non-Small-Cell Lung Cancer (NSCLC) During Chemotherapy Completed NCT00115206 Phase 4
29 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy Completed NCT02805153 Phase 4
30 Antifungal Use in Oncohematological Neutropenic Patients Completed NCT00386802 Phase 4
31 An Expanded Access Program of Pegfilgrastim (Neulastim) in Participants With Non-Hodgkin's Lymphoma (NHL) Completed NCT02782845 Phase 4
32 Safety Study of Adjuvant Docetaxel-Carboplatin Treatment for Resected Lung Cancer Completed NCT00883675 Phase 4
33 Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer Completed NCT02441894 Phase 4
34 Acetato de Caspofungin (Cancidas®) in the Treatment of Fungal Infection Completed NCT00388167 Phase 4
35 PEG-rhG-CSF in Patients With Lymphoma Receiving Chemotherapy Completed NCT02805218 Phase 4
36 PEG-rhG-CSF in Patients With Malignant Solid Tumors Receiving Chemotherapy Completed NCT02805166 Phase 4
37 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4
38 Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection Completed NCT01198236 Phase 4
39 Antifugal Effect of Recombinant Human Granulocyte-macrophage Stimulating Factor (rhGM-CSF) in Patients Post Allo-HSCT Completed NCT01232504 Phase 4
40 SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia Completed NCT00487448 Phase 4
41 Oral Zinc Therapy for the Prevention of Mucositis Completed NCT00449592 Phase 4
42 Phase II Trial Evaluating Irinotecan and Capecitabine Relapsed/Refractory Upper GI Tumours Completed NCT00220168 Phase 4
43 Prospective, Open-label Tolerability and Safety Monitoring Study of Novantrone in a Selected Cohort of Multiple Sclerosis Patients Completed NCT00262314 Phase 4
44 A Study of The Relationship Between Drop in Hemoglobin and Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Copegus (Ribavirin) and Pegasys (Peginterferon Alfa-2a) Completed NCT01585324 Phase 4
45 Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3 Completed NCT00056862 Phase 4
46 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
47 Epirubicin Versus Docetaxel Plus Cyclophosphamide in Lymph Node Negative, ER-positive, Her2-negative Breast Cancer Recruiting NCT02549677 Phase 4
48 Belatacept 3 Month Post Transplant Conversion Study Recruiting NCT02213068 Phase 4
49 Blood Draw Validation for Ciprofloxacin Pharmacokinetic Research in Pediatric Cancer Patients Recruiting NCT02967341 Phase 4
50 Granulocyte-colony Stimulating Factors or Antibiotics for Primary Prophylaxis for Febrile Neutropenia Recruiting NCT02816112 Phase 4

Search NIH Clinical Center for Neutropenia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Neutropenia cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: neutropenia

Genetic Tests for Neutropenia

Genetic tests related to Neutropenia:

id Genetic test Affiliating Genes
1 Neutropenia 29

Anatomical Context for Neutropenia

MalaCards organs/tissues related to Neutropenia:

39
Neutrophil, Myeloid, Bone, Breast, Lung, Bone Marrow, T Cells

Publications for Neutropenia

Articles related to Neutropenia:

(show top 50) (show all 1558)
id Title Authors Year
1
Prospective cohort study of procalcitonin levels in children with cancer presenting with febrile neutropenia. ( 28056911 )
2017
2
A Truncated G-CSFR Inhibits Apoptosis Induced by Neutrophil Elastase G185R Mutant: Implication for Understanding CSF3R Mutations in Severe Congenital Neutropenia. ( 28073911 )
2017
3
Poikiloderma with Neutropenia in Morocco: a Report of Four Cases. ( 28353165 )
2017
4
Granulocyte colony-stimulating factors in the prevention of febrile neutropenia: review of cost-effectiveness models. ( 28064553 )
2017
5
Extended infusion compared to standard infusion cefepime as empiric treatment of febrile neutropenia. ( 28077047 )
2017
6
Plasma presepsin level is an early diagnostic marker of severe febrile neutropenia in hematologic malignancy patients. ( 28056845 )
2017
7
Granulocyte colony-stimulating factor receptor signaling in severe congenital neutropenia, chronic neutrophilic leukemia, and related malignancies. ( 27789332 )
2017
8
Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia. ( 27975098 )
2017
9
Suspected immune-mediated neutropenia and corticosteroid responsive pancytopenia in a Portuguese water dog. ( 28042161 )
2017
10
A novel homozygous VPS45 p.P468L mutation leading to severe congenital neutropenia with myelofibrosis. ( 28453180 )
2017
11
Idiosyncratic drug-induced neutropenia & agranulocytosis. ( 28069912 )
2017
12
Association of time to antibiotics and clinical outcomes in adult hematologic malignancy patients with febrile neutropenia. ( 28077045 )
2017
13
An update on the diagnosis and treatment of chronic idiopathic neutropenia. ( 27841775 )
2017
14
Sepsis and persisting neutropenia in a drug addict. ( 28052478 )
2017
15
Predictive performance of the quick Sequential Organ Failure Assessment score as a screening tool for sepsis, mortality, and intensive care unit admission in patients with febrile neutropenia. ( 28062972 )
2017
16
Patterns of growth factor usage and febrile neutropenia among older patients with diffuse large B-cell non-Hodgkin lymphoma treated with CHOP or R-CHOP: the Intergroup experience (CALGB 9793; ECOG-SWOG 4494). ( 27967294 )
2016
17
Effectiveness of Granulocyte Colony-Stimulating Factor in Hospitalized Infants with Neutropenia. ( 27649291 )
2016
18
Use of biomarkers in the management of febrile neutropenia episodes in children with cancer. ( 27208564 )
2016
19
Augmented Renal Clearance in Pediatric Patients With Febrile Neutropenia Associated With Vancomycin Clearance. ( 27172381 )
2016
20
Early Changes of Mannose-Binding Lectin, H-Ficolin, and Procalcitonin in Patients with Febrile Neutropenia: A Prospective Observational Study. ( 26377840 )
2016
21
Neutropenia is independently associated with sub-therapeutic serum concentration of vancomycin. ( 28025029 )
2016
22
Application of whole-exome sequencing to unravel the molecular basis of undiagnosed syndromic congenital neutropenia with intellectual disability. ( 27615324 )
2016
23
Phenotypic Heterogeneity of Neutropenia and Gastrointestinal Illness Associated with G6PC3 Founder Mutation. ( 27571123 )
2016
24
Brucella abortus Causing Febrile Neutropenia Together with Epididymoorchitis. ( 27173647 )
2016
25
Risk of Neutropenia-Related Hospitalization in Patients Who Received Colony-Stimulating Factors With Chemotherapy for Breast Cancer. ( 27646945 )
2016
26
Granulocyte transfusions in critically ill children with prolonged neutropenia: side effects and survival rates from a single-center analysis. ( 27631588 )
2016
27
Neutropenia as a prognostic factor and safety of second-line therapy with S-1 for advanced or recurrent pancreatic cancer. ( 27588194 )
2016
28
ANA-Negative Presentation of SLE in Man with Severe Autoimmune Neutropenia. ( 28077945 )
2016
29
Copper deficiency as a cause of neutropenia in a case of coeliac disease. ( 27635061 )
2016
30
Carbapenems and febrile neutropenia. ( 28025134 )
2016
31
Late-onset neutropenia after rituximab in ANCA-associated vasculitis. ( 26948245 )
2016
32
Emerging agents for the prevention of treatment induced neutropenia in adult cancer patients. ( 27139914 )
2016
33
Risk-stratification management of febrile neutropenia in pediatric hematology-oncology patients: Results of a French nationwide survey. ( 27569451 )
2016
34
MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia. ( 27574191 )
2016
35
Severe Neutropenia at the Time of Implantable Subcutaneous Chest Port Insertion Is Not a Risk Factor for Port Removal at a Tertiary Pediatric Center. ( 28034702 )
2016
36
Upfront Chemohormonal Therapy for Prostate Cancer: Neutropenia and G-CSF Use. ( 27163905 )
2016
37
A One-Day-Old Girl With Neutropenia. ( 27215975 )
2016
38
Impact of a clinical pathway on appropriate empiric vancomycin use in cancer patients with febrile neutropenia. ( 27609336 )
2016
39
Capnocytophaga ochracea-related Bacterium Bacteremia in a Hypertrophic Cardiomyopathy Patient without Neutropenia. ( 27629977 )
2016
40
Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction. ( 27128488 )
2016
41
Outcomes in adult critically Ill cancer patients with and without neutropenia: a systematic review and meta-analysis of the Groupe de Recherche en RAcanimation Respiratoire du patient d'Onco-HAcmatologie (GRRR-OH). ( 27661125 )
2016
42
Procalcitonin-guided protocol is not useful to manage antibiotic therapy in febrile neutropenia: a randomized controlled trial. ( 27118539 )
2016
43
An international, multicenter, prospective, observational study of neutropenia in patients being treated with lenalidomidea88+a88dexamethasone for relapsed or relapsed/refractory multiple myeloma (RR-MM). ( 27169523 )
2016
44
Prospective cohort study of febrile neutropenia in breast cancer patients with neoadjuvant and adjuvant chemotherapy: CSPOR-BC FN study. ( 27162322 )
2016
45
Minor populations of paroxysmal nocturnal haemoglobinuria type cells in patients with chronic idiopathic neutropenia. ( 27124520 )
2016
46
Neutropenia in the Febrile Child. ( 27139294 )
2016
47
A Severe Congenital Neutropenia Type 4 Case (G6PC3 Mutation) Presented With Large Platelets in the Peripheral Smear. ( 26808373 )
2016
48
Carbapenems and febrile neutropenia - author's reply. ( 28025133 )
2016
49
Chemotherapy-induced neutropenia among pediatric cancer patients in Egypt: Risks and consequences. ( 27588196 )
2016
50
Incidence and Predictors of Febrile Neutropenia among Early-Stage Breast Cancer Patients Receiving Anthracycline-Based Chemotherapy in Korea. ( 27623006 )
2016

Variations for Neutropenia

ClinVar genetic disease variations for Neutropenia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 VPS13B NM_017890.4(VPS13B): c.11314C> T (p.Gln3772Ter) single nucleotide variant Pathogenic/Likely pathogenic rs386834061 GRCh37 Chromosome 8, 100880540: 100880540
2 VPS13B NM_017890.4(VPS13B): c.4620delA (p.Ser1541Profs) deletion Pathogenic rs1057518939 GRCh37 Chromosome 8, 100523652: 100523652

Expression for Neutropenia

Search GEO for disease gene expression data for Neutropenia.

Pathways for Neutropenia

GO Terms for Neutropenia

Biological processes related to Neutropenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.58 CSF2 CSF3 GFI1
2 cytokine-mediated signaling pathway GO:0019221 9.46 CSF3 CSF3R IFNA1 IL3
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.43 CSF3 HAX1 IL3
4 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.37 CSF2 IL3
5 positive regulation of actin cytoskeleton reorganization GO:2000251 9.32 CSF3 HAX1
6 immune response GO:0006955 9.1 CSF2 CSF3 FCGR3A FCGR3B IL3 WAS
7 neutrophil differentiation GO:0030223 8.96 CSF2 JAGN1

Molecular functions related to Neutropenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 8.96 FCGR3A FCGR3B
2 cytokine activity GO:0005125 8.92 CSF2 CSF3 IFNA1 IL3

Sources for Neutropenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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