MCID: NTR004
MIFTS: 60

Neutropenia

Categories: Rare diseases, Blood diseases, Genetic diseases, Bone diseases, Immune diseases, Nephrological diseases

Aliases & Classifications for Neutropenia

Summaries for Neutropenia

CDC : 3 Preventing Infections in Cancer Patients is a campaign focused on providing resources that will help reduce the risk of developing potentially life-threatening infections during chemotherapy treatment.

MalaCards based summary : Neutropenia, also known as leukopenia, is related to cyclic neutropenia and severe congenital neutropenia autosomal dominant. An important gene associated with Neutropenia is VPS13B (Vacuolar Protein Sorting 13 Homolog B), and among its related pathways/superpathways are Immune response Role of DAP12 receptors in NK cells and Jak-STAT signaling pathway (KEGG). The drugs Lenograstim and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include breast, myeloid and lung, and related phenotypes are hematopoietic system and immune system

Wikipedia : 72 Neutropenia or neutropaenia is an abnormally low concentration of neutrophils (a type of white blood... more...

Related Diseases for Neutropenia

Diseases in the Neutropenia family:

Neutropenia, Chronic Familial Neutropenia, Severe Congenital, 1, Autosomal Dominant
Neutropenia, Severe Congenital, 3, Autosomal Recessive Neutropenia, Severe Congenital, 4, Autosomal Recessive
Neutropenia, Severe Congenital, 2, Autosomal Dominant Neutropenia, Severe Congenital, 5, Autosomal Recessive
Neutropenia, Severe Congenital, 6, Autosomal Recessive Neutropenia, Severe Congenital, 7, Autosomal Recessive
Severe Congenital Neutropenia Severe Congenital Neutropenia Autosomal Dominant

Diseases related to Neutropenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 384)
# Related Disease Score Top Affiliating Genes
1 cyclic neutropenia 34.0 CSF2 CSF3 ELANE IL3
2 severe congenital neutropenia autosomal dominant 33.9 ELANE GFI1
3 neonatal alloimmune neutropenia 33.7 CD177 FCGR3B
4 felty syndrome 32.9 CSF2 CSF3 ELANE IL3
5 severe congenital neutropenia 32.4 CSF2 CSF3 CSF3R ELANE G6PC3 GFI1
6 leukemia, acute lymphoblastic 31.0 CSF3 IL3 TPMT
7 zygomycosis 30.3 CSF3 ELANE
8 lymphoma, hodgkin, classic 30.2 CSF2 CSF3 IL3
9 leukemia, acute myeloid 30.2 CSF2 CSF3 CSF3R GFI1 IL3
10 dyskeratosis congenita 29.9 CSF2 CSF3 USB1
11 neutrophilia, hereditary 29.8 CSF2 CSF3R
12 aplastic anemia 29.8 CSF2 CSF3 CSF3R IL3
13 myelodysplastic syndrome 29.7 CSF2 CSF3 CSF3R IL3 TOP1
14 myelofibrosis 29.6 CD177 CSF3 IL3 VPS45
15 granulocytopenia 29.6 CSF2 CSF3 IL3
16 pancytopenia 29.3 CSF2 CSF3 TPMT
17 acute lymphocytic leukemia 29.1 CSF2 CSF3 TPMT
18 poikiloderma with neutropenia 12.4
19 neutropenia, severe congenital, 3, autosomal recessive 12.4
20 neutropenia, nonimmune chronic idiopathic, of adults 12.3
21 neutropenia, severe congenital, x-linked 12.3
22 idiopathic neutropenia 12.3
23 3-methylglutaconic aciduria with cataracts, neurologic involvement, and neutropenia 12.2
24 neutropenia, severe congenital, 5, autosomal recessive 12.2
25 neutropenia, severe congenital, 7, autosomal recessive 12.2
26 neutropenia, severe congenital, 1, autosomal dominant 12.2
27 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 12.2
28 neutropenia, severe congenital, 4, autosomal recessive 12.2
29 neutropenia, severe congenital, 2, autosomal dominant 12.1
30 neutropenia, severe congenital, 6, autosomal recessive 12.1
31 transient neonatal neutropenia 12.0
32 barth syndrome 12.0
33 neutropenia, chronic familial 11.9
34 elane-related neutropenia 11.9
35 neutropenia, lethal congenital, with eosinophilia 11.8
36 onychotrichodysplasia and neutropenia 11.8
37 neutropenia monocytopenia deafness 11.8
38 autosomal recessive severe congenital neutropenia due to cxcr2 deficiency 11.8
39 hermansky-pudlak syndrome 2 11.5
40 clpb deficiency 11.5
41 whim syndrome 11.4
42 wiskott-aldrich syndrome 11.2
43 glycogen storage disease ib 11.2
44 large granular lymphocyte leukemia 11.1
45 immunodeficiency with hyper-igm, type 1 11.1
46 cohen syndrome 11.1
47 propionic acidemia 11.1
48 immunodeficiency 50 10.9
49 ablepharon-macrostomia syndrome 10.8
50 lichtenstein syndrome 10.8

Comorbidity relations with Neutropenia via Phenotypic Disease Network (PDN): (show all 50)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Leukemia Agammaglobulinemia, X-Linked
Anemia, Autoimmune Hemolytic Bladder Cancer
Bronchitis Chronic Kidney Failure
Colorectal Cancer Decubitus Ulcer
Deficiency Anemia Esophageal Cancer
Esophageal Candidiasis Esophagitis
Felty Syndrome Female Breast Cancer
Gastric Cancer Heart Disease
Hepatic Encephalopathy Hydronephrosis
Hypersplenism Hypothyroidism
Immune Deficiency Disease Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1
Intestinal Obstruction Iron Deficiency Anemia
Leukemia, Chronic Lymphocytic Lymphoblastic Leukemia
Main Bronchus Cancer Megakaryocytic Leukemia
Oral Candidiasis Ovarian Cancer
Paralytic Ileus Plasma Cell Neoplasm
Pneumocystosis Portal Hypertension
Postinflammatory Pulmonary Fibrosis Primary Thrombocytopenia
Protein-Energy Malnutrition Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 2
Rectal Neoplasm Respiratory Failure
Retinitis Pigmentosa and Erythrocytic Microcytosis Rheumatoid Arthritis
Sideroblastic Anemia Systemic Lupus Erythematosus
Waldenstrom Macroglobulinemia Wegener Granulomatosis

Graphical network of the top 20 diseases related to Neutropenia:



Diseases related to Neutropenia

Symptoms & Phenotypes for Neutropenia

MGI Mouse Phenotypes related to Neutropenia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CD177 CSF2 CSF3 CSF3R ELANE FCGR3B
2 immune system MP:0005387 9.36 CD177 CSF2 CSF3 CSF3R ELANE FCGR3B

Drugs & Therapeutics for Neutropenia

Drugs for Neutropenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 496)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 124-94-7 31307
3
Cilastatin Approved, Investigational Phase 4 82009-34-5 6435415 5280454
4
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
5
Meropenem Approved, Investigational Phase 4,Phase 2 119478-56-7 441130 64778
6
Ceftazidime Approved Phase 4,Phase 3,Phase 2 72558-82-8, 78439-06-2 5481173
7
Piperacillin Approved Phase 4,Phase 2 66258-76-2 43672
8
Tazobactam Approved Phase 4,Phase 2 89786-04-9 123630
9
Vancomycin Approved Phase 4,Phase 3,Phase 2 1404-90-6 14969 441141
10
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 477468 3081921
11
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
12
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
13
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
14
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
15
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
16
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137234-62-9 71616
17
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
18
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
19
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
20
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054
21
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 23214-92-8 31703
22
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
23
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
24
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
25
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
26
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
27
Epirubicin Approved Phase 4,Phase 2,Phase 3,Phase 1 56420-45-2 41867
28
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
29
Methotrexate Approved Phase 4,Phase 2,Phase 3 1959-05-2, 59-05-2 126941
30
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
31
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 1 154361-50-9 60953
32
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
33
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2 84625-61-6 55283
34
Teicoplanin Approved, Investigational Phase 4 61036-62-2
35
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
36
Tobramycin Approved, Investigational Phase 4,Phase 3 32986-56-4 36294 5496
37
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
38
Diphenhydramine Approved, Investigational Phase 4,Phase 3,Phase 1 58-73-1, 147-24-0 3100
39
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
40
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
41
Histamine Approved, Investigational Phase 4,Phase 1 51-45-6, 75614-87-8 774
42
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
43
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
44
Ondansetron Approved Phase 4,Phase 3,Phase 1 99614-02-5 4595
45
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
46
Promethazine Approved, Investigational Phase 4,Phase 3,Phase 1 60-87-7 4927
47
Ranitidine Approved Phase 4 66357-59-3, 66357-35-5 3001055
48
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 171228-49-2 147912
49
Caspofungin Approved Phase 4,Phase 3,Phase 2,Phase 1 162808-62-0, 179463-17-3 2826718 468682
50
Fludarabine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 21679-14-1, 75607-67-9 30751

Interventional clinical trials:

(show top 50) (show all 710)

# Name Status NCT ID Phase Drugs
1 Prevention of Neutropenia After Using G-CSF With TAC Chemotherapy Unknown status NCT01571518 Phase 4 late leukostim;early leukostim
2 Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO Unknown status NCT02149329 Phase 4 Discontinuation of imipenem-cilastatin or meropenem
3 Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia Unknown status NCT02463747 Phase 4 Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
4 Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer Unknown status NCT00030758 Phase 4
5 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4 Micafungin
6 Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda Unknown status NCT00674921 Phase 4 cotrimoxazole;Placebo
7 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Unknown status NCT02605213 Phase 4 Vancomycin;Placebo
8 Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia Completed NCT01581333 Phase 4 Empirical antimicrobial treatment discontinuation;Standard empirical antimicrobial treatment discontinuation
9 Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia Completed NCT02213783 Phase 4 Imipenem;Imipenem
10 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy to Prevent Neutropenia Completed NCT02805205 Phase 4 PEG-rhG-CSF
11 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen Completed NCT01107756 Phase 4 LENOGRASTIM (GRANOGYTE 34)
12 Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer Completed NCT01649635 Phase 4 CABAZITAXEL (XRP6258);Prednisone;Ciprofloxacin;G-CSF (Granulocyte colony-stimulating factor)
13 A Study of Empirical Antifungal Therapy With Itraconazole Completed NCT01706562 Phase 4 Itraconazole
14 REaCT Integrated Consent Model to Compare Two Standard of Care Regimens Completed NCT02173262 Phase 4 G-CSF;Ciprofloxacin
15 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy Completed NCT02805153 Phase 4 PEG-rhG-CSF;rhG-CSF
16 Neulasta® in Subjects With Advanced Non-Small-Cell Lung Cancer (NSCLC) During Chemotherapy Completed NCT00115206 Phase 4 Neulasta® (pegfilgrastim)
17 A Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis After Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer Completed NCT00277160 Phase 4 Neulasta (pegfilgrastim)
18 FIRST - Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy Completed NCT00125723 Phase 4
19 Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients Completed NCT01401010 Phase 4 Doripenem;doripenem
20 The Relationship of Defeverscence and Itraconazole Plasma Level Study in Immunocompromised Participants Completed NCT01021683 Phase 4 Itraconazole
21 Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients Completed NCT00454272 Phase 4 Teicoplanin;Vancomycin
22 Observational Study Investigating the Response Rate of Itraconazole Injection in Treating Immunocompromised Patients Completed NCT01060462 Phase 4 Pts. w/ neutropenic fever associated w/ hematologic malignancy
23 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
24 Antifungal Use in Oncohematological Neutropenic Patients Completed NCT00386802 Phase 4 Antifungal drug. VORICONAZOL. (VFEND®)
25 The Tobramycin Study Completed NCT00257790 Phase 4 Tobramycin once a day
26 An Expanded Access Program of Pegfilgrastim (Neulastim) in Participants With Non-Hodgkin's Lymphoma (NHL) Completed NCT02782845 Phase 4 Chemotherapy;Immunochemotherapy;Pegfilgrastim
27 Safety of Cotrimoxazole in HIV- and HAART-exposed Infants Completed NCT01086878 Phase 4 cotrimoxazole
28 Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients Completed NCT01114165 Phase 4
29 Safety Study of Adjuvant Docetaxel-Carboplatin Treatment for Resected Lung Cancer Completed NCT00883675 Phase 4 Docetaxel-Carboplatin
30 Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer Completed NCT02441894 Phase 4 CABAZITAXEL XRP6258;PEG-G-CSF;Prednisolone;Dexchlorpheniramine or Diphenhydramine;Ranitidine;Metoclopramide, Granisetron, or Ondansetron;Dexamethasone
31 Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115) Completed NCT00686543 Phase 4 Posaconazole
32 Acetato de Caspofungin (Cancidas®) in the Treatment of Fungal Infection Completed NCT00388167 Phase 4 Caspofungin
33 PEG-rhG-CSF in Patients With Lymphoma Receiving Chemotherapy Completed NCT02805218 Phase 4 PEG-rhG-CSF
34 PEG-rhG-CSF in Patients With Malignant Solid Tumors Receiving Chemotherapy Completed NCT02805166 Phase 4 PEG-rhG-CSF
35 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
36 Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma Completed NCT00969462 Phase 4 Doxorubicin
37 Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection Completed NCT01198236 Phase 4 Itraconazole
38 Antifugal Effect of Recombinant Human Granulocyte-macrophage Stimulating Factor (rhGM-CSF) in Patients Post Allo-HSCT Completed NCT01232504 Phase 4 rhGM-CSF group;rhG-CSF+rhGM-CSF group;rhG-CSF group
39 SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia Completed NCT00487448 Phase 4 Fludarabine;Cytarabine;G-CSF;Idarubicin
40 Oral Zinc Therapy for the Prevention of Mucositis Completed NCT00449592 Phase 4 Zinc;Placebo
41 Phase II Trial Evaluating Irinotecan and Capecitabine Relapsed/Refractory Upper GI Tumours Completed NCT00220168 Phase 4 Irinotecan, Capecitabine
42 Prospective, Open-label Tolerability and Safety Monitoring Study of Novantrone in a Selected Cohort of Multiple Sclerosis Patients Completed NCT00262314 Phase 4
43 A Study of The Relationship Between Drop in Hemoglobin and Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Copegus (Ribavirin) and Pegasys (Peginterferon Alfa-2a) Completed NCT01585324 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin [Copegus]
44 Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3 Completed NCT00056862 Phase 4 Peginterferon alfa-2a;Peginterferon alfa-2a;Ribavirin
45 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
46 PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia Recruiting NCT02996617 Phase 4 rhG-CSF regimen;Pegylated rhG-CSF regimen
47 Granulocyte-colony Stimulating Factors or Antibiotics for Primary Prophylaxis for Febrile Neutropenia Recruiting NCT02816112 Phase 4 Ciprofloxacin;Neupogen
48 A Study to Compare Administration Schedules of G-CSF (Filgrastim) for Primary Prophylaxis of Febrile Neutropenia Recruiting NCT02816164 Phase 4 Neupogen
49 The Efficacy and Safety of PEG-rhG-CSF in Neutropenia After Chemotherapy Recruiting NCT02905916 Phase 4 PEG-rhG-CSF
50 Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg Recruiting NCT02621905 Phase 4 Sporanox;Lozanoc

Search NIH Clinical Center for Neutropenia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Neutropenia cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: neutropenia

Genetic Tests for Neutropenia

Genetic tests related to Neutropenia:

# Genetic test Affiliating Genes
1 Leukopenia 28
2 Neutropenia 28

Anatomical Context for Neutropenia

MalaCards organs/tissues related to Neutropenia:

38
Breast, Myeloid, Lung, Neutrophil, Bone, Bone Marrow, T Cells

Publications for Neutropenia

Articles related to Neutropenia:

(show top 50) (show all 1639)
# Title Authors Year
1
Risk stratification for febrile neutropenia in patients with testicular germ cell tumors. ( 29349917 )
2018
2
The<i>JAK2</i>V617F mutation in isolated neutropenia. ( 29383013 )
2018
3
Procalcitonin Guiding Antimicrobial Therapy Duration in Febrile Cancer Patients with Documented Infection or Neutropenia. ( 29348438 )
2018
4
Comparison of antipseudomonal beta-lactams for febrile neutropenia empiric therapy: systematic review and network meta-analysis: authors' reply. ( 29427805 )
2018
5
Neutropenia as a Complication of Tumefactive Demyelinating Disease: A Case Report. ( 29330070 )
2018
6
Real-World Impact of a Decision Support Tool on Colony-Stimulating Factor Use and Chemotherapy-Induced Febrile Neutropenia Among Patients With Breast Cancer. ( 29439177 )
2018
7
Type 1 autoimmune hepatitis presenting with severe autoimmune neutropenia. ( 29333079 )
2018
8
Re-randomization increased recruitment and provided similar treatment estimates as parallel designs in trials of febrile neutropenia. ( 29428873 )
2018
9
Quantitative Relationship Between AUEC of Absolute Neutrophil Count and Duration of Severe Neutropenia for G-CSF in Breast Cancer Patients. ( 29392707 )
2018
10
The Infectious and Non-Infectious Etiology, Clinical Picture and Outcome of Neutropenia in Immunocompetent Hospitalized Children. ( 29319583 )
2018
11
Successful second hematopoietic cell transplantation in severe congenital neutropenia. ( 29076228 )
2018
12
Calculated decisions: MASCC Risk Index for febrile neutropenia ( 29323859 )
2018
13
Adult-onset primary cyclic autoimmune neutropenia: a case report. ( 29405299 )
2018
14
Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia. ( 29451309 )
2018
15
Management of Patients With Febrile Neutropenia: A Teachable Moment. ( 29435575 )
2018
16
Cost-effectiveness and Improved Parent and Provider Satisfaction With Outpatient Management of Pediatric Oncology Patients, With Low-risk Fever and Neutropenia. ( 29334532 )
2018
17
Reply to "Comparison of antipseudomonal betalactams for febrile neutropenia empiric therapy: systematic review and network meta-analysis" by Horita et al. ( 29410224 )
2018
18
Biosimilar filgrastim vs filgrastim: a multicenter nationwide observational bioequivalence study in patients with chemotherapy-induced neutropenia. ( 29403286 )
2018
19
Efficacy of micafungin for the treatment of invasive candidiasis and candidaemia in patients with neutropenia. ( 29364548 )
2018
20
Early discontinuation of empirical antibacterial therapy in febrile neutropenia: the ANTIBIOSTOP study. ( 29451055 )
2018
21
Congenital neutropenia in the era of genomics: classification, diagnosis, and natural history. ( 28875503 )
2017
22
Evaluation of serum galactomannan enzyme immunoassay at two different cut-offs for the diagnosis of invasive aspergillosis in patients with febrile neutropenia. ( 28681812 )
2017
23
Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia. ( 27975098 )
2017
24
Cytotoxic T cells in chronic idiopathic neutropenia express restricted antigen receptors. ( 28535087 )
2017
25
Sepsis and persisting neutropenia in a drug addict. ( 28052478 )
2017
26
Refining the role of pegfilgrastim (a long-acting G-CSF) for prevention of chemotherapy-induced febrile neutropenia: consensus guidance recommendations. ( 28842778 )
2017
27
Plasma presepsin level is an early diagnostic marker of severe febrile neutropenia in hematologic malignancy patients. ( 28056845 )
2017
28
Chemotherapy-induced neutropenia and the prognosis of colorectal cancer: a meta-analysis of cohort studies. ( 28910204 )
2017
29
Impaired lung repair during neutropenia can be reverted by matrix metalloproteinase-9. ( 28947666 )
2017
30
Prognostic importance of temozolomide-induced neutropenia in glioblastoma, IDH-wildtype patients. ( 28887717 )
2017
31
Risk of Febrile Neutropenia Associated With Select Myelosuppressive Chemotherapy Regimens in a Large Community-Based Oncology Practice. ( 28874597 )
2017
32
Effect of FCGR polymorphism on the occurrence of late-onset neutropenia and flare-free survival in rheumatic patients treated with rituximab. ( 28270182 )
2017
33
Association of time to antibiotics and clinical outcomes in adult hematologic malignancy patients with febrile neutropenia. ( 28077045 )
2017
34
Diagnostic value of sTREM-1, IL-8, PCT, and CRP in febrile neutropenia after autologous stem cell transplantation. ( 28920169 )
2017
35
Extended infusion compared to standard infusion cefepime as empiric treatment of febrile neutropenia. ( 28077047 )
2017
36
Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. ( 28414293 )
2017
37
Time trends in utilization of G-CSF prophylaxis and risk of febrile neutropenia in a Medicare population receiving adjuvant chemotherapy for early-stage breast cancer. ( 28921379 )
2017
38
UGT1A1 Gene Polymorphism Predicts Irinotecan-Induced Severe Neutropenia and Diarrhea in Chinese Cancer Patients. ( 28879724 )
2017
39
A novel homozygous VPS45 p.P468L mutation leading to severe congenital neutropenia with myelofibrosis. ( 28453180 )
2017
40
Immunoglobulin and B-cell disturbances in patients with chronic idiopathic neutropenia. ( 28732781 )
2017
41
Meta-analysis on the Influence of Antifungal Spectrum on Effectiveness of Empirical Antifungal Therapy for Febrile Neutropenia. ( 28867698 )
2017
42
Predictive performance of the quick Sequential Organ Failure Assessment score as a screening tool for sepsis, mortality, and intensive care unit admission in patients with febrile neutropenia. ( 28062972 )
2017
43
Elastase inhibitors as potential therapies for ELANE-associated neutropenia. ( 28754797 )
2017
44
Soluble CD14 as a Diagnostic and Prognostic Biomarker in Hematological Patients with Febrile Neutropenia. ( 28845081 )
2017
45
Non-chemotherapy drug-induced neutropenia - an update. ( 28879784 )
2017
46
Treatment with granulocyte colony-stimulating factor in the refeeding phase of anorexia nervosa complicated with severe neutropenia and sepsis: a case report. ( 28871553 )
2017
47
Idiosyncratic drug-induced neutropenia & agranulocytosis. ( 28069912 )
2017
48
Suspected immune-mediated neutropenia and corticosteroid responsive pancytopenia in a Portuguese water dog. ( 28042161 )
2017
49
External Validation of Six Pediatric Fever and Neutropenia Clinical Decision Rules. ( 28877157 )
2017
50
Severe Neutropenia After Leukocytosis During an Acute Attack of Mycoplasma Infection-associated Paroxysmal Cold Hemoglobinuria. ( 28234745 )
2017

Variations for Neutropenia

ClinVar genetic disease variations for Neutropenia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 VPS13B NM_017890.4(VPS13B): c.11314C> T (p.Gln3772Ter) single nucleotide variant Pathogenic/Likely pathogenic rs386834061 GRCh37 Chromosome 8, 100880540: 100880540
2 VPS13B NM_017890.4(VPS13B): c.4620delA (p.Ser1541Profs) deletion Pathogenic rs1057518939 GRCh37 Chromosome 8, 100523652: 100523652

Expression for Neutropenia

Search GEO for disease gene expression data for Neutropenia.

Pathways for Neutropenia

GO Terms for Neutropenia

Biological processes related to Neutropenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 CSF2 CSF3 FCGR3B IL3 WAS
2 cellular response to lipopolysaccharide GO:0071222 9.58 CSF2 CSF3 GFI1
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.5 CSF3 HAX1 IL3
4 positive regulation of actin cytoskeleton reorganization GO:2000251 9.37 CSF3 HAX1
5 regulation of myeloid cell differentiation GO:0045637 9.16 CSF2 CSF3R
6 neutrophil migration GO:1990266 8.96 CD177 JAGN1
7 neutrophil differentiation GO:0030223 8.8 CSF2 CSF3 JAGN1

Sources for Neutropenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
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36 KEGG
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41 MeSH
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58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
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