MCID: NTR004
MIFTS: 64

Neutropenia malady

Genetic diseases, Blood diseases, Rare diseases categories
Download this MalaCard

Summaries for Neutropenia

About this section


Fully expand this MalaCard
Wikipedia:65 Neutropenia or neutropaenia, from Latin prefix neutro- (neither, for neutral staining) and Greek suffix... more...

MalaCards based summary: Neutropenia is related to felty's syndrome and cyclic hematopoiesis. An important gene associated with Neutropenia is GFI1 (growth factor independent 1 transcription repressor), and among its related pathways are Selected targets of C EBPalpha and Transcriptional misregulation in cancer. The drugs ciprofloxacin and itraconazole and the compounds bmmp and pkh 2 have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, myeloid and bone, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Neutropenia

About this section

Neutropenia, Aliases & Descriptions:

Name: Neutropenia 30 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Blood diseases


External Ids:

Disease Ontology8 DOID:1227
MeSH34 D009503
ICD9CM27 288.00, 288.0

Related Diseases for Neutropenia

About this section

Diseases in the Severe Congenital Neutropenia family:

neutropenia Elane-Related Neutropenia
Neutropenia Chronic Familial Gata1-Related Neutropenia
Susceptibility to Neutropenia Due to Mercaptopurine Treatment Susceptibility to Neutropenia Due to Azathioprine Treatment

Diseases related to Neutropenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 336)
idRelated DiseaseScoreTop Affiliating Genes
1felty's syndrome31.3CSF2, IL3
2cyclic hematopoiesis31.3ELANE, CSF2, IL3
3severe congenital neutropenia31.1IL3, ELANE, CSF2, CSF3R, KITLG, GFI1
4severe congenital neutropenia autosomal recessive 330.9ELANE, IL3, CSF2, CSF3R
5sepsis30.8FCGR3A, ELANE, CSF2
6leukemia30.6THPO, KITLG, CSF2, CD177, GFI1, CSF3R
7dyskeratosis congenita30.5CSF2, KITLG
8primary immunodeficiency disease30.4WAS
9myeloid leukemia30.4CSF3R, IL3, ELANE, THPO, CSF2, KITLG
10rheumatoid arthritis30.4THPO, FCGR3A, ELANE, CSF2
11non-hodgkin lymphoma30.3FCGR3A, CSF2, IL3, KITLG
12hypersplenism30.3THPO
13thrombocytopenia30.3KITLG, CSF2, IL3, WAS, THPO, FCGR3A
14pancytopenia30.2THPO, IL3, CSF2
15acute lymphoblastic leukemia30.2CSF3R, CSF2, IL3, THPO, KITLG
16aplastic anemia30.2THPO, CSF2, IL3, KITLG
17myelofibrosis30.2THPO, IL3
18myelodysplastic syndromes30.1CSF2, IL3, CD177, KITLG, THPO, CSF3R
19acute leukemia30.1KITLG, CSF2, IL3, THPO, CSF3R
20chronic lymphocytic leukemia29.9THPO, CSF2, CSF3R
21refractory anemia29.7THPO, IL3, CSF2, KITLG
22idiopathic neutropenia10.7
23poikiloderma with neutropenia10.6
24breast cancer10.5
25neonatal neutropenia10.5
26lung cancer10.5
27bacteremia10.5
28barth syndrome10.4
29acute myeloid leukemia10.4
30leukopenia10.4
31arthritis10.4
32wegener's granulomatosis10.4ELANE
33severe congenital neutropenia x-linked10.4
34leukemoid reaction10.4CSF2, IL3
35glycogen storage disease10.3
36lymphopenia10.3
37capillary leak syndrome10.3ELANE, CSF2
38hematopoietic stem cell transplantation10.3
39hepatitis10.3
40x-linked thrombocytopenia10.3THPO, WAS
41congenital amegakaryocytic thrombocytopenia10.3IL3, THPO
42hodgkin's lymphoma10.3
43periodontitis10.3
44systemic lupus erythematosus10.3
45lupus erythematosus10.3
46aspergillosis10.3
47myopathy10.3
48large granular lymphocyte leukemia10.3
49severe congenital neutropenia, autosomal recessive, 410.3
50neutropenia, severe congenital 1, autosomal dominant10.3

Graphical network of the top 20 diseases related to Neutropenia:



Diseases related to neutropenia

Symptoms for Neutropenia

About this section

Drugs & Therapeutics for Neutropenia

About this section

Drug clinical trials:

Search ClinicalTrials for Neutropenia

Search NIH Clinical Center for Neutropenia

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Neutropenia cell therapies at LifeMap Discovery.

Genetic Tests for Neutropenia

About this section

Anatomical Context for Neutropenia

About this section

MalaCards organs/tissues related to Neutropenia:

32
Neutrophil, Myeloid, Bone, Lung, Breast, Bone marrow, T cells, Skin, B cells, Liver, Monocytes, Kidney, Brain, Whole blood, Spleen, Smooth muscle, Pancreas, Prostate, Tonsil, Endothelial

Animal Models for Neutropenia or affiliated genes

About this section

MGI Mouse Phenotypes related to Neutropenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5KITLG, CSF2, IL3, ELANE, WAS
2MP:00053848.4HAX1, GFI1, WAS, IL3, CSF2, CSF3R
3MP:00053977.2FCGR3A, GFI1, KITLG, CSF3R, CSF2, THPO
4MP:00053877.1THPO, GFI1, FCGR3A, G6PC3, KITLG, CSF3R

Publications for Neutropenia

About this section

Articles related to Neutropenia:

(show top 50)    (show all 1369)
idTitleAuthorsYear
1
Recurrent Dermatophytosis (Majocchi granuloma) Associated With Chemotherapy-Induced Neutropenia. (24470005)
2014
2
Intermittent neutropenia as an early feature of mild mevalonate kinase deficiency. (24177804)
2014
3
Tacrolimus-induced neutropenia in a cardiac transplant patient. (24384051)
2014
4
A case of endogenous endophthalmitis complicated by neutropenia following bacteremia with Streptococcus mitis resistant to beta-lactam antibiotics. (22830590)
2013
5
Continuation of Deferiprone Therapy in Patients with Mild Neutropenia May Not Lead to a More Severe Drop in Neutrophil Count. (24330079)
2013
6
Comparative effectiveness of pegfilgrastim, filgrastim, and sargramostim prophylaxis for neutropenia-related hospitalization: two US retrospective claims analyses. (23016568)
2013
7
Cost-effectiveness of filgrastim and pegfilgrastim as primary prophylaxis against febrile neutropenia in lymphoma patients. (23873405)
2013
8
Treatment of fungal disease in the setting of neutropenia. (24319214)
2013
9
Squamous cell carcinoma in a child with Clericuzio-type poikiloderma with neutropenia. (22924337)
2013
10
Prospective randomized study of cefepime, panipenem, or meropenem monotherapy for patients with hematological disorders and febrile neutropenia. (22948387)
2013
11
External validation of a risk model of febrile neutropenia occurrence in patients with non-Hodgkin lymphoma. (23452152)
2013
12
Lenograstim in preventing chemotherapy-induced febrile neutropenia in patients with soft tissue sarcoma. (23393367)
2013
13
A novel G6PC3 gene mutation in a patient with severe congenital neutropenia. (23018568)
2013
14
Urinary tract infections in pediatric oncology patients with fever and neutropenia. (22304012)
2012
15
A novel compound heterozygous HAX1 mutation in a Chinese patient with severe congenital neutropenia and chronic myelomonocytic leukemia transformation but without neurodevelopmental abnormalities. (22102707)
2012
16
The diagnostic value of interleukin-6 and interleukin-8 for early prediction of bacteremia and sepsis in children with febrile neutropenia and cancer. (22367386)
2012
17
Guidelines for pediatric management of severe chronic neutropenia. (22237723)
2012
18
A cost analysis of febrile neutropenia management in Australia: ambulatory v. in-hospital treatment. (22126955)
2011
19
Extended-interval aminoglycoside therapy for adult patients with febrile neutropenia: a systematic review. (22479053)
2011
20
Single nucleotide polymorphisms in the human TNF gene are associated with anaemia and neutropenia in a cohort of patients with de novo myelodysplastic syndrome. (20618340)
2010
21
Targeted next-generation sequencing appoints c16orf57 as clericuzio- type poikiloderma with neutropenia gene. (20004881)
2010
22
Mutations in C16orf57 and normal-length telomeres unify a subset of patients with dyskeratosis congenita, poikiloderma with neutropenia and Rothmund-Thomson syndrome. (20817924)
2010
23
Dose-dependent risk of neutropenia after 7-day courses of artesunate monotherapy in Cambodian patients with acute Plasmodium falciparum malaria. (21070142)
2010
24
A syndrome with congenital neutropenia and mutations in G6PC3. (19118303)
2009
25
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
26
The effect of granulocyte colony-stimulating factor (G-CSF) on the activity of granulocyte enzymes in children with cancer who developed neutropenia after chemotherapy. (18614436)
2008
27
Severe congenital neutropenia: new genes explain an old disease. (17917547)
2007
28
Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. (16584360)
2006
29
Severe congenital neutropenia: genetics and pathogenesis. (18528462)
2006
30
The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy. (16497969)
2006
31
Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia. (16391909)
2006
32
Severe neutropenia in Japanese patients with x-linked agammaglobulinemia. (16160918)
2005
33
Cyclic neutropenia with anti-NA2 antibodies and treatment with recombinant granulocyte colony-stimulating factor]. (16045884)
2005
34
The role of colony-stimulating factors and granulocyte transfusion in treatment options for neutropenia in children with cancer. (14510625)
2003
35
Acute lymphocytic leukemia after fulminant varicella associated with severe neutropenia. (12940335)
2003
36
Resistance to recombinant human granulocyte colony-stimulating factor in neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies. (11927737)
2002
37
Clinical implications of mutations of neutrophil elastase in congenital and cyclic neutropenia. (11846296)
2001
38
Spontaneous remission of granulocyte colony-stimulating factor-associated leukemia in a child with severe congenital neutropenia. (11071667)
2000
39
Granulocyte colony-stimulating factor receptor mutations in severe congenital neutropenia transforming to acute myelogenous leukemia confer resistance to apoptosis and enhance cell survival. (10706885)
2000
40
Prophylactic administration of granulocyte colony-stimulating factor when monocytopenia appears lessens neutropenia caused by chemotherapy for lung cancer. (10857893)
2000
41
Serum granulocyte colony-stimulating factor levels in patients with chronic neutropenia of childhood: modulation of G-CSF levels by myeloid precursor cell mass. (10233425)
1999
42
Dominantly inherited severe congenital neutropenia. (8890001)
1996
43
Reduction of granulocyte activation during hemodialysis with regional citrate anticoagulation: dissociation of complement activation and neutropenia from neutrophil degranulation. (8785392)
1996
44
The effect of continuous G-CSF application in human cyclic neutropenia: a model analysis. (7540416)
1995
45
Contrasting effects of recombinant human granulocyte-macrophage colony-stimulating factor (CSF) and granulocyte CSF treatment on the cycling of blood elements in childhood-onset cyclic neutropenia. (7519479)
1994
46
C-reactive protein: a valuable aid for the management of febrile children with cancer and neutropenia. (8038314)
1994
47
Intervention treatment of established neutropenia with human recombinant granulocyte-macrophage colony-stimulating factor (rhGM-CSF) in patients undergoing cancer chemotherapy. (8429694)
1993
48
Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkin's lymphoma: a randomized controlled trial. (1381626)
1992
49
Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia. (1978690)
1990
50
Glycogenosis type Ib complicated by severe granulocytopenia resembling inherited neutropenia. (6944203)
1981

Variations for Neutropenia

About this section

Expression for genes affiliated with Neutropenia

About this section
Expression patterns in normal tissues for genes affiliated with Neutropenia

Search GEO for disease gene expression data for Neutropenia.

Pathways for genes affiliated with Neutropenia

About this section

Compounds for genes affiliated with Neutropenia

About this section

Compounds related to Neutropenia according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1bmmp4410.2CSF2, IL3
2pkh 24410.1IL3, KITLG
3daniplestim4410.0IL3, KITLG
4molgramostim4410.0CSF2, IL3
5anaphylatoxin4410.0ELANE, IL3, CSF2
6pyronin y449.9KITLG, THPO
7n-formylmethionyl-leucylphenylalanine449.8CSF2, ELANE, IL3
8ifosfamide44 1110.8IL3, THPO, CSF2
9pegfilgrastim44 1110.8CSF3R, IL3, ELANE, CSF2
104-hydroperoxycyclophosphamide449.8KITLG, IL3, CSF2
11as 10144 6110.8KITLG, IL3, CSF2
12leucovorin44 50 1111.7IL3, THPO, CSF2
13a23187449.7CSF2, IL3
14ivig449.7CSF2, IL3, FCGR3A
15neopterin449.7CSF2, IL3, ELANE
16valine449.7CSF2, FCGR3A, ELANE, IL3
17hydrocortisone44 2 61 1112.5CSF2, KITLG, IL3, ELANE
18mesna449.5CSF2, IL3
19calcitriol44 61 24 1112.5GFI1, IL3, CSF2, KITLG
20imatinib44 50 1111.5KITLG, IL3, THPO, CSF3R
21herbimycin a44 6110.5FCGR3A, CSF2, IL3, KITLG
22mafosfamide449.4CSF2, IL3, THPO, KITLG
23pixy321449.4THPO, IL3, CSF2, KITLG
24amifostine44 1110.4THPO, KITLG, IL3, CSF2
25carboplatin44 50 1111.4KITLG, CSF2, IL3, THPO
26hydroxyurea44 50 1111.4CSF2, KITLG, THPO, IL3
27dmso449.4THPO, CSF2, CSF3R, KITLG
28aspirin44 50 28 2412.4THPO, CSF2, KITLG, ELANE
29cytarabine44 50 1111.4THPO, KITLG, CSF2, IL3
30daunorubicin44 50 1111.4KITLG, CSF2, IL3
315fluorouracil449.3THPO, IL3, KITLG, CSF2
32agar449.2KITLG, CSF2, IL3, THPO
33rantes449.2THPO, IL3, KITLG, CSF2
34gm-csf44 2810.2ELANE, THPO, IL3, CSF2, KITLG
35superoxide44 2410.2CSF3R, KITLG, THPO, ELANE, CSF2
36methylcellulose449.2CSF2, THPO, IL3, CSF3R, KITLG
37gp 130449.2THPO, IL3, CSF2, CSF3R, KITLG
38lactate449.1IL3, ELANE, KITLG, CSF2, THPO
39fmlp449.1THPO, FCGR3A, ELANE, IL3, CSF3R, CSF2
40genistein44 28 61 2 24 1114.1CSF2, IL3, KITLG, CSF3R, THPO
41wortmannin449.1WAS, IL3, CSF2, KITLG, THPO
42thymidine44 2410.1CSF3R, IL3, KITLG, CSF2, THPO
43butyrate449.0CSF2, KITLG, THPO, IL3
44polysaccharide449.0CSF2, KITLG, THPO, IL3
45filgrastim44 1110.0CSF3R, KITLG, CSF2, IL3, ELANE, THPO
46heparin44 28 24 1111.9IL3, CSF3R, CSF2, KITLG, ELANE, THPO
47h2o2448.9IL3, ELANE, CSF2, KITLG, THPO
48retinoic acid44 249.8THPO, ELANE, KITLG, CSF3R, CSF2, IL3
49phosphatidylinositol448.6CSF2, WAS, THPO, IL3, KITLG, FCGR3A
50tyrosine448.3CD177, KITLG, CSF3R, IL3, CSF2, WAS

GO Terms for genes affiliated with Neutropenia

About this section

Cellular components related to Neutropenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6KITLG, CSF3R, CSF2, IL3, ELANE, FCGR3A

Biological processes related to Neutropenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7CSF2, IL3
2embryonic hemopoiesisGO:0351629.7KITLG, IL3
3positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5HAX1, IL3, KITLG
4positive regulation of DNA replicationGO:0457409.5IL3, CSF2, KITLG
5immune responseGO:0069559.2CSF2, IL3, WAS, FCGR3A
6blood coagulationGO:0075968.8THPO, CD177, WAS, VPS45

Molecular functions related to Neutropenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0KITLG, CSF2, IL3, THPO
2growth factor activityGO:0080838.7KITLG, CSF2, IL3, THPO

Products for genes affiliated with Neutropenia

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Neutropenia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet