MCID: NTR004
MIFTS: 64

Neutropenia malady

Genetic diseases, Blood diseases, Rare diseases categories
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Summaries for Neutropenia

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4CDC, 65Wikipedia, 33MalaCards
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CDC:4 People receiving chemotherapy are at risk for developing an infection when their white blood cell count is low. White blood cells are the body's main defense against infection. This condition, called neutropenia, is common after receiving chemotherapy. For patients with this condition, any infection can become serious quickly.

MalaCards: Neutropenia is related to severe congenital neutropenia and felty's syndrome. An important gene associated with Neutropenia is GFI1 (growth factor independent 1 transcription repressor), and among its related pathways are Selected targets of C EBPalpha and Transcriptional misregulation in cancer. The drugs immunoglobulins, intravenous and ciprofloxacin and the compounds bmmp and pkh 2 have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and lung, and related mouse phenotypes are tumorigenesis and cellular.

Wikipedia:65 Neutropenia or neutropaenia, from Latin prefix neutro- (neither, for neutral staining) and Greek suffix... more...

Aliases & Classifications for Neutropenia

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8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

neutropenia 8 10 45 31 62


External Ids:

Disease Ontology8 DOID:1227
ICD9CM27 288.00, 288.0
MeSH35 D009503

Related Diseases for Neutropenia

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17GeneCards, 18GeneDecks
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Diseases in the Severe Congenital Neutropenia family:

neutropenia Elane-Related Neutropenia
Neutropenia Chronic Familial Gata1-Related Neutropenia

Diseases related to Neutropenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 327)
idRelated DiseaseScoreTop Affiliating Genes
1severe congenital neutropenia31.4KITLG, CSF3R, CSF2, IL3, ELANE, GFI1
2felty's syndrome31.0CSF2, IL3
3leukemia30.9THPO, GFI1, IL3, CSF2, CSF3R, KITLG
4cyclic hematopoiesis30.9CSF2, IL3, ELANE
5sepsis30.7FCGR3A, ELANE, CSF2
6severe congenital neutropenia autosomal recessive 330.6ELANE, IL3, CSF2, CSF3R
7myeloid leukemia30.6THPO, ELANE, IL3, CSF2, CSF3R, KITLG
8thrombocytopenia30.5THPO, FCGR3A, WAS, IL3, CSF2, KITLG
9rheumatoid arthritis30.4CSF2, ELANE, FCGR3A, THPO
10myelodysplastic syndromes30.3THPO, IL3, CSF2, CSF3R, KITLG, CD177
11dyskeratosis congenita30.3KITLG, CSF2
12non-hodgkin lymphoma30.3FCGR3A, IL3, CSF2, KITLG
13acute leukemia30.2KITLG, CSF3R, CSF2, IL3, THPO
14aplastic anemia30.1KITLG, CSF2, IL3, THPO
15acute lymphocytic leukemia29.9THPO, IL3, CSF2, CSF3R, KITLG
16primary immunodeficiency disease29.8WAS
17hypersplenism29.8THPO
18myelofibrosis29.8IL3, THPO
19pancytopenia29.8CSF2, IL3, THPO
20chronic myelomonocytic leukemia29.8KITLG, CSF3R, CSF2
21chronic lymphocytic leukemia29.7CSF3R, CSF2, THPO
22refractory anemia29.7THPO, IL3, CSF2, KITLG
23idiopathic neutropenia10.6
24poikiloderma with neutropenia10.5
25breast cancer10.5
26lung cancer10.5
27acute myeloid leukemia10.4
28bacteremia10.4
29barth syndrome10.4
30leukopenia10.4
31severe congenital neutropenia x-linked10.4
32arthritis10.3
33lymphopenia10.3
34glycogen storage disease10.3
35hepatitis10.3
36hodgkin's lymphoma10.3
37hematopoietic stem cell transplantation10.3
38periodontitis10.3
39neutropenia, severe congenital 1, autosomal dominant10.3
40systemic lupus erythematosus10.2
41aspergillosis10.2
42lupus erythematosus10.2
43myopathy10.2
44large granular lymphocyte leukemia10.2
45severe congenital neutropenia, autosomal recessive, 410.2
46hepatitis c10.2
47lymphoblastic leukemia10.2
48agammaglobulinemia10.2
49pancreatitis10.2
50pneumonia10.2

Graphical network of the top 20 diseases related to Neutropenia:



Diseases related to neutropenia

Symptoms for Neutropenia

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Drugs & Therapeutics for Neutropenia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Neutropenia

Search NIH Clinical Center for Neutropenia

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Neutropenia cell therapies at LifeMap Discovery.

Genetic Tests for Neutropenia

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Anatomical Context for Neutropenia

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33MalaCards
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MalaCards organs/tissues related to Neutropenia:

33
Myeloid, Bone, Lung, Breast, Bone marrow, T cells, Skin, B cells, Liver, Monocytes, Kidney, Brain, Tonsil, Prostate, Pancreas, Smooth muscle, Spleen, Whole blood, Endothelial

Animal Models for Neutropenia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Neutropenia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5WAS, ELANE, IL3, CSF2, KITLG
2MP:00053848.4KITLG, CSF3R, CSF2, IL3, WAS, GFI1
3MP:00053977.2KITLG, HAX1, THPO, GFI1, FCGR3A, G6PC3
4MP:00053877.1FCGR3A, GFI1, THPO, HAX1, G6PC3, WAS

Publications for Neutropenia

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52PubMed
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Articles related to Neutropenia:

(show top 50)    (show all 1309)
idTitleAuthorsYear
1
Tacrolimus-induced neutropenia in a cardiac transplant patient. (24384051)
2014
2
A case of endogenous endophthalmitis complicated by neutropenia following bacteremia with Streptococcus mitis resistant to beta-lactam antibiotics. (22830590)
2013
3
Continuation of Deferiprone Therapy in Patients with Mild Neutropenia May Not Lead to a More Severe Drop in Neutrophil Count. (24330079)
2013
4
Comparative effectiveness of pegfilgrastim, filgrastim, and sargramostim prophylaxis for neutropenia-related hospitalization: two US retrospective claims analyses. (23016568)
2013
5
Cost-effectiveness of filgrastim and pegfilgrastim as primary prophylaxis against febrile neutropenia in lymphoma patients. (23873405)
2013
6
Treatment of fungal disease in the setting of neutropenia. (24319214)
2013
7
Squamous cell carcinoma in a child with Clericuzio-type poikiloderma with neutropenia. (22924337)
2013
8
Prospective randomized study of cefepime, panipenem, or meropenem monotherapy for patients with hematological disorders and febrile neutropenia. (22948387)
2013
9
External validation of a risk model of febrile neutropenia occurrence in patients with non-Hodgkin lymphoma. (23452152)
2013
10
Lenograstim in preventing chemotherapy-induced febrile neutropenia in patients with soft tissue sarcoma. (23393367)
2013
11
A novel G6PC3 gene mutation in a patient with severe congenital neutropenia. (23018568)
2013
12
Urinary tract infections in pediatric oncology patients with fever and neutropenia. (22304012)
2012
13
A novel compound heterozygous HAX1 mutation in a Chinese patient with severe congenital neutropenia and chronic myelomonocytic leukemia transformation but without neurodevelopmental abnormalities. (22102707)
2012
14
The diagnostic value of interleukin-6 and interleukin-8 for early prediction of bacteremia and sepsis in children with febrile neutropenia and cancer. (22367386)
2012
15
Guidelines for pediatric management of severe chronic neutropenia. (22237723)
2012
16
Management of febrile neutropenia in an acute oncology service. (22080099)
2012
17
A cost analysis of febrile neutropenia management in Australia: ambulatory v. in-hospital treatment. (22126955)
2011
18
Extended-interval aminoglycoside therapy for adult patients with febrile neutropenia: a systematic review. (22479053)
2011
19
Single nucleotide polymorphisms in the human TNF gene are associated with anaemia and neutropenia in a cohort of patients with de novo myelodysplastic syndrome. (20618340)
2010
20
Targeted next-generation sequencing appoints c16orf57 as clericuzio- type poikiloderma with neutropenia gene. (20004881)
2010
21
Mutations in C16orf57 and normal-length telomeres unify a subset of patients with dyskeratosis congenita, poikiloderma with neutropenia and Rothmund-Thomson syndrome. (20817924)
2010
22
Dose-dependent risk of neutropenia after 7-day courses of artesunate monotherapy in Cambodian patients with acute Plasmodium falciparum malaria. (21070142)
2010
23
A syndrome with congenital neutropenia and mutations in G6PC3. (19118303)
2009
24
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
25
The effect of granulocyte colony-stimulating factor (G-CSF) on the activity of granulocyte enzymes in children with cancer who developed neutropenia after chemotherapy. (18614436)
2008
26
Severe congenital neutropenia: new genes explain an old disease. (17917547)
2007
27
Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. (16584360)
2006
28
Severe congenital neutropenia: genetics and pathogenesis. (18528462)
2006
29
The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy. (16497969)
2006
30
Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia. (16391909)
2006
31
Severe neutropenia in Japanese patients with x-linked agammaglobulinemia. (16160918)
2005
32
Cyclic neutropenia with anti-NA2 antibodies and treatment with recombinant granulocyte colony-stimulating factor]. (16045884)
2005
33
A comparison of cyclic neutropenia in childhood and severe congenital neutropenia. (16079089)
2005
34
The role of colony-stimulating factors and granulocyte transfusion in treatment options for neutropenia in children with cancer. (14510625)
2003
35
Acute lymphocytic leukemia after fulminant varicella associated with severe neutropenia. (12940335)
2003
36
Resistance to recombinant human granulocyte colony-stimulating factor in neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies. (11927737)
2002
37
Clinical implications of mutations of neutrophil elastase in congenital and cyclic neutropenia. (11846296)
2001
38
Spontaneous remission of granulocyte colony-stimulating factor-associated leukemia in a child with severe congenital neutropenia. (11071667)
2000
39
Granulocyte colony-stimulating factor receptor mutations in severe congenital neutropenia transforming to acute myelogenous leukemia confer resistance to apoptosis and enhance cell survival. (10706885)
2000
40
Prophylactic administration of granulocyte colony-stimulating factor when monocytopenia appears lessens neutropenia caused by chemotherapy for lung cancer. (10857893)
2000
41
Serum granulocyte colony-stimulating factor levels in patients with chronic neutropenia of childhood: modulation of G-CSF levels by myeloid precursor cell mass. (10233425)
1999
42
Dominantly inherited severe congenital neutropenia. (8890001)
1996
43
Reduction of granulocyte activation during hemodialysis with regional citrate anticoagulation: dissociation of complement activation and neutropenia from neutrophil degranulation. (8785392)
1996
44
The effect of continuous G-CSF application in human cyclic neutropenia: a model analysis. (7540416)
1995
45
Contrasting effects of recombinant human granulocyte-macrophage colony-stimulating factor (CSF) and granulocyte CSF treatment on the cycling of blood elements in childhood-onset cyclic neutropenia. (7519479)
1994
46
C-reactive protein: a valuable aid for the management of febrile children with cancer and neutropenia. (8038314)
1994
47
Intervention treatment of established neutropenia with human recombinant granulocyte-macrophage colony-stimulating factor (rhGM-CSF) in patients undergoing cancer chemotherapy. (8429694)
1993
48
Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkin's lymphoma: a randomized controlled trial. (1381626)
1992
49
Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia. (1978690)
1990
50
Glycogenosis type Ib complicated by severe granulocytopenia resembling inherited neutropenia. (6944203)
1981

Variations for Neutropenia

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Expression for genes affiliated with Neutropenia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neutropenia

Search GEO for disease gene expression data for Neutropenia.

Pathways for genes affiliated with Neutropenia

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50PathCards, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 60Thomson Reuters
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Compounds for genes affiliated with Neutropenia

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45Novoseek, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 3BitterDB, 24HMDB, 29IUPHAR
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Compounds related to Neutropenia according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1bmmp4510.2CSF2, IL3
2pkh 24510.1IL3, KITLG
3daniplestim4510.0IL3, KITLG
4molgramostim4510.0CSF2, IL3
5anaphylatoxin4510.0ELANE, IL3, CSF2
6pyronin y459.9KITLG, THPO
7n-formylmethionyl-leucylphenylalanine459.8CSF2, ELANE, IL3
8ifosfamide45 1110.8IL3, THPO, CSF2
9pegfilgrastim45 1110.8CSF3R, IL3, ELANE, CSF2
104-hydroperoxycyclophosphamide459.8KITLG, IL3, CSF2
11as 10145 6110.8KITLG, IL3, CSF2
12leucovorin45 51 1111.7IL3, THPO, CSF2
13a23187459.7CSF2, IL3
14ivig459.7CSF2, IL3, FCGR3A
15neopterin459.7CSF2, IL3, ELANE
16valine459.7CSF2, FCGR3A, ELANE, IL3
17hydrocortisone45 3 61 1112.5CSF2, KITLG, IL3, ELANE
18mesna459.5CSF2, IL3
19calcitriol45 61 24 1112.5GFI1, IL3, CSF2, KITLG
20imatinib45 51 1111.5KITLG, IL3, THPO, CSF3R
21herbimycin a45 6110.5FCGR3A, CSF2, IL3, KITLG
22mafosfamide459.4CSF2, IL3, THPO, KITLG
23pixy321459.4THPO, IL3, CSF2, KITLG
24amifostine45 1110.4THPO, KITLG, IL3, CSF2
25carboplatin45 51 1111.4KITLG, CSF2, IL3, THPO
26hydroxyurea45 51 1111.4CSF2, KITLG, THPO, IL3
27dmso459.4THPO, CSF2, CSF3R, KITLG
28aspirin45 51 29 2412.4THPO, CSF2, KITLG, ELANE
29cytarabine45 51 1111.4THPO, KITLG, CSF2, IL3
30daunorubicin45 51 1111.4KITLG, CSF2, IL3
315fluorouracil459.3THPO, IL3, KITLG, CSF2
32agar459.2KITLG, CSF2, IL3, THPO
33rantes459.2THPO, IL3, KITLG, CSF2
34gm-csf45 2910.2ELANE, THPO, IL3, CSF2, KITLG
35superoxide45 2410.2CSF3R, KITLG, THPO, ELANE, CSF2
36methylcellulose459.2CSF2, THPO, IL3, CSF3R, KITLG
37gp 130459.2THPO, IL3, CSF2, CSF3R, KITLG
38lactate459.1IL3, ELANE, KITLG, CSF2, THPO
39fmlp459.1THPO, FCGR3A, ELANE, IL3, CSF3R, CSF2
40genistein45 29 61 3 24 1114.1CSF2, IL3, KITLG, CSF3R, THPO
41wortmannin459.1WAS, IL3, CSF2, KITLG, THPO
42thymidine45 2410.1CSF3R, IL3, KITLG, CSF2, THPO
43butyrate459.0CSF2, KITLG, THPO, IL3
44polysaccharide459.0CSF2, KITLG, THPO, IL3
45filgrastim45 1110.0CSF3R, KITLG, CSF2, IL3, ELANE, THPO
46heparin45 29 24 1111.9IL3, CSF3R, CSF2, KITLG, ELANE, THPO
47h2o2458.9IL3, ELANE, CSF2, KITLG, THPO
48retinoic acid45 249.8THPO, ELANE, KITLG, CSF3R, CSF2, IL3
49phosphatidylinositol458.6CSF2, WAS, THPO, IL3, KITLG, FCGR3A
50tyrosine458.3CD177, KITLG, CSF3R, IL3, CSF2, WAS

GO Terms for genes affiliated with Neutropenia

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16Gene Ontology
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Cellular components related to Neutropenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6KITLG, CSF3R, CSF2, IL3, ELANE, FCGR3A

Biological processes related to Neutropenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7CSF2, IL3
2embryonic hemopoiesisGO:0351629.7KITLG, IL3
3positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5KITLG, IL3, HAX1
4positive regulation of DNA replicationGO:0457409.5KITLG, CSF2, IL3
5immune responseGO:0069559.2FCGR3A, WAS, IL3, CSF2
6blood coagulationGO:0075968.8THPO, VPS45, WAS, CD177

Molecular functions related to Neutropenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0KITLG, CSF2, IL3, THPO
2growth factor activityGO:0080838.7KITLG, CSF2, IL3, THPO

Products for genes affiliated with Neutropenia

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Sources for Neutropenia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet