MCID: NTR004
MIFTS: 65

Neutropenia malady

Summaries for Neutropenia

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3CDC, 63Wikipedia, 32MalaCards
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CDC:3 People receiving chemotherapy are at risk for developing an infection when their white blood cell count is low. White blood cells are the body's main defense against infection. This condition, called neutropenia, is common after receiving chemotherapy. For patients with this condition, any infection can become serious quickly.

MalaCards: Neutropenia is related to severe congenital neutropenia and leukemia. An important gene associated with Neutropenia is GFI1 (growth factor independent 1 transcription repressor), and among its related pathways are PAK Pathway and Akt Signaling. The drugs immunoglobulins, intravenous and ciprofloxacin and the compounds tyrosine and phosphatidylinositol have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and lung, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:63 Neutropenia, occasionally spelled neutropaenia or neutropoenia, from Latin prefix neutro- (neither, for... more...

Aliases & Classifications for Neutropenia

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

neutropenia 8 10 44 30 60


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Disease Ontology8 DOID:1227
MeSH34 D009503
ICD9CM27 288.00, 288.0

Related Diseases for Neutropenia

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17GeneCards, 18GeneDecks
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Diseases in the Severe Congenital Neutropenia family:

neutropenia Elane-Related Neutropenia
Neutropenia Chronic Familial Gata1-Related Neutropenia

Diseases related to Neutropenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 320)
idRelated DiseaseScoreTop Affiliating Genes
1severe congenital neutropenia31.4IL3, LEF1, BIRC5, KITLG, GFI1, THPO
2leukemia31.0CSF3R, CSF2, CSF3, CSF1, CD177, RECQL4
3acute leukemia30.8CSF3R, CSF2, CSF3, CSF1, IL3, BIRC5
4felty's syndrome30.8CSF2, CSF3, IL3
5cyclic hematopoiesis30.8CSF2, CSF3, CSF1, IL3, ELANE
6breast cancer30.7CSF3R, CSF2, CSF3, CSF1, LEF1, BIRC5
7lung cancer30.6CSF2, CSF3, BIRC5
8myeloid leukemia30.6CSF3R, CSF2, CSF3, CSF1, IL3, FPR1
9thrombocytopenia30.5CSF2, CSF3, CSF1, WAS, IL3, KITLG
10severe congenital neutropenia autosomal recessive 330.5IL3, CSF3, CSF2, CSF3R, ELANE
11arthritis30.4C5AR1, FCGR3A, CSF1, CSF2
12poikiloderma with neutropenia30.4USB1
13glycogen storage disease30.4CSF3
14rheumatoid arthritis30.4CSF2, CSF1, FCGR3A, THPO, C5AR1, ELANE
15aspergillosis30.3ELANE, CSF1
16hepatitis c30.2THPO
17non-hodgkin lymphoma30.2CSF2, CSF3, IL3, BIRC5, KITLG, FCGR3A
18colorectal cancer30.2KITLG, BIRC5, LEF1
19pancreatitis30.2ELANE, KITLG
20pneumonia30.2CSF2, CSF3, C5AR1, ELANE
21dyskeratosis congenita30.1KITLG, CSF2
22chronic myeloid leukemia30.1CSF3R, CSF2, CSF3, CD177, IL3, LEF1
23aplastic anemia30.1CSF2, CSF3, CSF1, IL3, KITLG, THPO
24myeloma30.1CSF2, CSF3, CSF1, IL3, BIRC5, KITLG
25deficiency anemia30.1CSF3R, CSF2, CSF3, IL3, KITLG, THPO
26sarcoma30.1CSF1, KITLG, THPO
27multiple myeloma30.1CSF3
28vasculitis30.0ELANE
29rothmund-thomson syndrome30.0RECQL4
30hematologic cancer29.8CSF3R, CSF2, CSF3, CSF1, IL3, BIRC5
31acute lymphocytic leukemia29.8CSF3R, CSF2, CSF3, IL3, LEF1, KITLG
32chronic lymphocytic leukemia29.8CSF3R, CSF2, LEF1, BIRC5, THPO
33melanoma29.8CSF3R, CSF2, CSF1, LEF1, BIRC5, KITLG
34multiple sclerosis29.8CSF1, KITLG, THPO
35graft versus host disease29.8IL3, CSF3, CSF2
36tuberculosis29.8FPR1, C5AR1
37pancytopenia29.6CSF2, CSF3, CSF1, IL3, THPO
38monocytic leukemia29.6CSF1, CSF2, CSF3R
39non-small cell lung carcinoma29.6CSF2, CSF3, IL3, BIRC5, THPO
40neuroblastoma29.6CD177
41hypersplenism29.6THPO
42glomerulonephritis29.6ELANE, C5AR1
43purpura29.6THPO
44pancreatic cancer29.6BIRC5
45myelofibrosis29.6THPO, CD177
46prostate cancer29.6CSF3R, BIRC5, GFI1
47encephalitis29.6C5AR1
48acute myeloid leukemia10.4
49barth syndrome10.4
50idiopathic neutropenia10.4

Graphical network of the top 20 diseases related to Neutropenia:



Diseases related to neutropenia

Clinical Features for Neutropenia

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Drugs & Therapeutics for Neutropenia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Neutropenia

Drug clinical trials:

Search ClinicalTrials for Neutropenia

Search NIH Clinical Center for Neutropenia

Search CenterWatch for Neutropenia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Neutropenia cell therapies at LifeMap Discovery.

Genetic Tests for Neutropenia

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Anatomical Context for Neutropenia

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32MalaCards
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MalaCards organs/tissues related to Neutropenia:

32
Myeloid, Bone, Lung, Breast, Bone marrow, T cells, Skin, B cells, Liver, Monocytes, Kidney, Brain, Tonsil, Prostate, Pancreas, Smooth muscle, Spleen, Whole blood, Endothelial

Animal Models for Neutropenia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neutropenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.8ELANE, CSF3R, CSF2, CSF3, CSF1, WAS
2MP:000539711.6G6PC3, HAX1, WAS, CSF1, CSF3, CSF2
3MP:001076811.4CSF2, CSF1, HAX1, G6PC3, RECQL4, IL3
4MP:000538411.2CSF3R, CSF2, CSF1, WAS, HAX1, RECQL4
5MP:000537611.1CSF1, WAS, G6PC3, IL3, BIRC5, KITLG
6MP:000539011.0CSF2, CSF1, WAS, HAX1, RECQL4, LEF1
7MP:000537910.8CSF2, CSF1, WAS, IL3, FPR1, LEF1
8MP:000200610.4WAS, RECQL4, KITLG, ELANE

Publications for Neutropenia

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50PubMed
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Articles related to Neutropenia:

(show top 50)    (show all 1325)
idTitleAuthorsYear
1
Allogeneic stem cell transplantation for patients with acute myeloid leukaemia developing from severe congenital neutropenia. (24422727)
2014
2
Comparative effectiveness of pegfilgrastim, filgrastim, and sargramostim prophylaxis for neutropenia-related hospitalization: two US retrospective claims analyses. (23016568)
2013
3
A high angiopoietin-2/angiopoietin-1 ratio is associated with a high risk of septic shock in patients with febrile neutropenia. (23915833)
2013
4
Neutropenia and G-CSF in lymphoproliferative diseases. (23321273)
2013
5
Moxifloxacin-associated neutropenia. (23826791)
2013
6
Comment and reply on: pegfilgrastim is safe and effective in the prevention of neutropenia and treatment delays in biweekly regimens. (23445337)
2013
7
Recurrent neutropenia due to dopamine agonists in a patient with microprolactinoma. (23757609)
2013
8
Risk factors for febrile neutropenia among patients with cancer receiving chemotherapy: A systematic review. (24434034)
2013
9
Outpatient therapy for fever and neutropenia is safe but implementation is the key. (23358967)
2013
10
Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells. (23382209)
2013
11
Granocyte-colony stimulating factor (G-CSF) has significant efficacy as secondary prophylaxis of chemotherapy-induced neutropenia in patients with solid tumors: results of a prospective study. (23267161)
2013
12
Low C3 levels is associated with neutropenia in a proportion of patients with myelodysplastic syndrome: retrospective analysis. (22324951)
2012
13
Biomarkers for risk stratification of febrile neutropenia among children with malignancy: a pilot study. (22535591)
2012
14
A call for screening for benign neutropenia in Arab populations. (22273659)
2012
15
Advances in management of low-risk febrile neutropenia. (22037219)
2012
16
Prognostic value of chemotherapy-induced neutropenia in early-stage breast cancer. (21971729)
2012
17
Baseline platelet count and creatinine clearance rate predict the outcome of neutropenia-related invasive aspergillosis. (22423136)
2012
18
"Good enough" medicine: noninferiority clinical trials and the management of fever and neutropenia. (22422727)
2012
19
Hyper-IgM, neutropenia, mild infections and low response to polyclonal stimulation: hyper-IgM syndrome or common variable immunodeficiency? (22230404)
2011
20
Implementation of an evidence-based order set to impact initial antibiotic time intervals in adult febrile neutropenia. (22037329)
2011
21
Mutations in the ELANE gene are associated with development of periodontitis in patients with severe congenital neutropenia. (21796505)
2011
22
Levamisole induced necrosis of the skin and neutropenia following intranasal cocaine use: a newly recognized syndrome. (21968674)
2011
23
Identification of a homozygous deletion mutation in C16orf57 in a family with Clericuzio-type poikiloderma with neutropenia. (20503306)
2010
24
Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis. (20616219)
2010
25
Compound heterozygous HAX1 mutations in a Swedish patient with severe congenital neutropenia and no neurodevelopmental abnormalities. (19499579)
2009
26
Unrelated cord blood transplantation for severe congenital neutropenia: report of two cases with very different transplant courses. (18433408)
2008
27
Intermittent chronic neutropenia in a patient with familial Mediterranean fever. (18661496)
2008
28
Hemophagocytic syndrome in one patient with adult-onset Still's disease. Presentation with febrile neutropenia. (16550302)
2007
29
Neutrophil elastase in cyclic and severe congenital neutropenia. (17053055)
2007
30
Neutropenia in Felty's syndrome successfully treated with hydroxychloroquine. (17726769)
2007
31
Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia. (16391909)
2006
32
Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. (16804117)
2006
33
A semimechanistic-physiologic population pharmacokinetic/pharmacodynamic model for neutropenia following pemetrexed therapy. (16322990)
2006
34
Cyclic neutropenia with anti-NA2 antibodies and treatment with recombinant granulocyte colony-stimulating factor]. (16045884)
2005
35
Novel mechanism of G-CSF refractoriness in patients with severe congenital neutropenia. (15353486)
2005
36
Stem cell transplantation in patients with severe congenital neutropenia with evidence of leukemic transformation. (15640815)
2005
37
A novel mutation in the juxtamembrane intracellular sequence of the granulocyte colony-stimulating factor (G-CSF) receptor gene in a patient with severe congenital neutropenia augments GCSF proliferation activity but not through the MAP kinase cascade. (16229088)
2005
38
Effects of recombinant human interleukin 11 on thrombocytopenia and neutropenia in irradiated rhesus monkeys. (15387143)
2004
39
Economic evaluations of granulocyte colony-stimulating factor: in the prevention and treatment of chemotherapy-induced neutropenia. (14750898)
2003
40
The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure. (12963840)
2003
41
Congenital neutropenia. (14556775)
2003
42
Leukemia in severe congenital neutropenia: defective proteolysis suggests new pathways to malignancy and opportunities for therapy. (14533448)
2003
43
Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin's lymphoma receiving CHOP chemotherapy. (14959849)
2003
44
Leukemic transformation in patients with severe congenital neutropenia. (11878775)
2001
45
Colony-stimulating factors in the prevention of solid tumors induced by chemotherapy in patients with febrile neutropenia. (9624538)
1998
46
Action of granulocyte-macrophage colony-stimulating factor on incisional wound healing in congenital neutropenia. (7740436)
1995
47
Prolonged neutropenia resulting from antibodies to neutrophil-specific antigen NB1 following marrow transplantation. (8430456)
1993
48
Lymphocyte subsets associated with T cell receptor beta-chain gene rearrangement in patients with rheumatoid arthritis and neutropenia. (1315549)
1992
49
Gas gangrene following antibiotic-associated enterocolitis in hereditary neutropenia. (3985683)
1985
50
Neutropenia in dysgammaglobulinemia I: remission with immunoglobulin therapy. (7281709)
1981

Genetic Variations for Neutropenia

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Expression for genes affiliated with Neutropenia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neutropenia

Search GEO for disease gene expression data for Neutropenia.

Pathways for genes affiliated with Neutropenia

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51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Neutropenia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0CSF3R, CSF2, CSF3, CSF1, WAS, IL3
2
Hide members
11.0CSF3R, CSF2, CSF3, CSF1, WAS, IL3
310.9THPO, CSF3R, CSF2, CSF3, CSF1, IL3
410.8CSF3R, CSF3, CSF1, G6PC3, IL3, KITLG
5
Hide members
10.8CSF3R, CSF2, CSF3, CSF1, IL3, KITLG
6
Hide members
10.8CSF3R, CSF2, CSF1, LEF1, THPO
7
Hide members
10.7FCGR3A, IL3, WAS, CSF2
810.7IL3, CSF3, CSF2, CSF3R
910.7KITLG, BIRC5, LEF1, CSF3R
1010.7LEF1, KITLG, ELANE
1110.7C5AR1, FCGR3A, FPR1

Compounds for genes affiliated with Neutropenia

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
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Compounds related to Neutropenia according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.8BIRC5, LEF1, FPR1, IL3, CD177, WAS
2phosphatidylinositol4411.6FPR1, THPO, CSF3R, CSF2, C5AR1, CSF1
3fmlp4411.5CSF3R, IL3, CSF1, ELANE, C5AR1, THPO
4superoxide44 2412.5CSF1, FPR1, BIRC5, KITLG, THPO, ELANE
5wortmannin4411.4CSF2, WAS, IL3, FPR1, BIRC5, C5AR1
6retinoic acid44 2412.4ELANE, IL3, CSF1, CSF3R, CSF2, THPO
7filgrastim44 1112.4KITLG, ELANE, THPO, CSF3R, CSF2, IL3
8dmso4411.4CSF2, CSF3, FPR1, BIRC5, CSF3R, KITLG
9rantes4411.4FPR1, CSF2, CSF1, CSF3, KITLG, THPO
10methylcellulose4411.3CSF3, CSF1, CSF3R, CSF2, THPO, IL3
11n-formylmethionyl-leucylphenylalanine4411.3FPR1, C5AR1, ELANE, IL3, CSF1, CSF3
12genistein44 28 59 2 11 2416.3IL3, THPO, KITLG, BIRC5, FPR1, CSF2
13hydroxyurea44 49 1113.3CSF2, THPO, KITLG, IL3, RECQL4, CSF1
14gp 1304411.3CSF3R, THPO, CSF3, CSF1, IL3, KITLG
15vegf4411.3THPO, KITLG, BIRC5, C5AR1, CSF1, CSF3
16imatinib44 49 1113.3IL3, CSF3R, KITLG, BIRC5, CSF1, THPO
17heparin44 28 11 2414.3C5AR1, THPO, FPR1, CSF1, CSF2, CSF3R
18pixy3214411.3CSF3, THPO, KITLG, IL3, CSF1, CSF2
19alanine4411.3CSF3R, FPR1, CSF1, LEF1, THPO, KITLG
205fluorouracil4411.3THPO, CSF2, CSF3, CSF1, IL3, BIRC5
21thymidine44 2412.3CSF1, IL3, CSF2, CSF3, KITLG, CSF3R
22h2o24411.2RECQL4, IL3, C5AR1, THPO, FPR1, CSF2
23daunorubicin44 49 1113.2KITLG, CSF1, IL3, CSF3, CSF2, BIRC5
24pegfilgrastim44 1112.2CSF3, ELANE, IL3, CSF2, CSF3R
25carboplatin44 49 1113.2CSF1, CSF3, THPO, KITLG, IL3, CSF2
26leukotriene b444 59 2413.2FPR1, CSF1, IL3, C5AR1, CSF2, ELANE
27mafosfamide4411.2CSF2, IL3, CSF3, KITLG, THPO
28amifostine44 1112.2CSF2, CSF3, IL3, KITLG, THPO
29cytarabine44 49 1113.2IL3, CSF1, CSF2, CSF3, KITLG, THPO
30histamine44 28 2413.2IL3, CSF2, FPR1, C5AR1, THPO, KITLG
31anaphylatoxin4411.2FPR1, ELANE, IL3, CSF2, C5AR1
32pd 98,0594411.1CSF1, C5AR1, THPO, KITLG, BIRC5, IL3
33ifosfamide44 1112.1THPO, CSF2, CSF3, CSF1, IL3
34molgramostim4411.1IL3, CSF1, CSF3, CSF2
35mitoxantrone44 49 1113.1IL3, CSF1, CSF2, BIRC5, CSF3
36cytochalasin b4411.1BIRC5, FPR1, CSF2, C5AR1, ELANE
374-hydroperoxycyclophosphamide4411.1KITLG, IL3, CSF3, CSF2
38dexamethasone44 49 28 1114.0FPR1, KITLG, IL3, BIRC5
39rituximab44 49 1113.0CSF2, CSF3, CSF1, BIRC5, FCGR3A
40gm-csf44 2812.0THPO
41aspirin44 49 28 2414.0KITLG, CSF1, ELANE, CSF2, THPO, BIRC5
42endotoxin4410.9FPR1, CSF3, CSF3R
43bryostatin 14410.9BIRC5, IL3, CSF2, CSF1
44zidovudine44 1111.8CSF1, CSF2, KITLG, CSF3, IL3
45agar4410.8IL3, BIRC5, CSF1, CSF2, THPO, KITLG
46daniplestim4410.8KITLG, IL3, CSF3
47valine4410.8ELANE, IL3
48ltc44410.7IL3, CSF2, C5AR1, CSF1
49pyronin y4410.6KITLG, BIRC5, THPO
50pge24410.4BIRC5, FPR1, CSF2

GO Terms for genes affiliated with Neutropenia

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16Gene Ontology
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Cellular components related to Neutropenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.8THPO, KITLG, IL3, CSF1, CSF3, CSF2

Biological processes related to Neutropenia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.1C5AR1, FCGR3A, IL3, WAS, CSF3, CSF2
2positive regulation of cell proliferationGO:00828411.0CSF2, CSF3, CSF1, IL3, LEF1, BIRC5
3positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.9CSF3, HAX1, IL3, KITLG
4cellular response to cytokine stimulusGO:07134510.9LEF1, HAX1, CSF3
5positive regulation of DNA replicationGO:04574010.8KITLG, IL3, CSF2
6cellular response to lipopolysaccharideGO:07122210.7CSF2, CSF3, GFI1
7positive regulation of granulocyte differentiationGO:03085410.7LEF1, HAX1
8positive regulation of actin cytoskeleton reorganizationGO:200025110.6HAX1, CSF3
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.6IL3, CSF2
10positive regulation of macrophage derived foam cell differentiationGO:01074410.5CSF1, CSF2
11positive regulation of Ras protein signal transductionGO:04657910.3KITLG, CSF1

Molecular functions related to Neutropenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.7THPO, KITLG, IL3, CSF1, CSF3, CSF2
2N-formyl peptide receptor activityGO:00498210.6C5AR1, FPR1
3cytokine activityGO:00512510.5CSF2, CSF3, CSF1, IL3, KITLG, THPO

Products for genes affiliated with Neutropenia

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Sources for Neutropenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet