MCID: NTR004
MIFTS: 59

Neutropenia malady

Summaries for Neutropenia

Sources:
3CDC, 64Wikipedia, 33MalaCards
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CDC:3 People receiving chemotherapy are at risk for developing an infection when their white blood cell count is low. White blood cells are the body's main defense against infection. This condition, called neutropenia, is common after receiving chemotherapy. For patients with this condition, any infection can become serious quickly.

MalaCards: Neutropenia is related to severe congenital neutropenia and acute leukemia. An important gene associated with Neutropenia is GFI1 (growth factor independent 1 transcription repressor), and among its related pathways are PAK Pathway and Akt Signaling. The drugs immunoglobulins, intravenous and ciprofloxacin and the compounds tyrosine and phosphatidylinositol have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:64 Neutropenia, occasionally spelled neutropaenia or neutropoenia, from Latin prefix neutro- (neither, for... more...

Aliases & Classifications for Neutropenia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT
See all sources

Aliases & Descriptions:

neutropenia 8 10 45 31 61


External Ids:

Disease Ontology8 DOID:1227
MeSH35 D009503
ICD9CM27 288.00, 288.0

Related Diseases for Neutropenia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the severe congenital neutropenia family:

neutropenia neutropenia chronic familial

Diseases related to Neutropenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 321)
idRelated DiseaseScoreTop Affiliating Genes
1severe congenital neutropenia31.5IL3, LEF1, BIRC5, KITLG, GFI1, THPO
2acute leukemia30.9BIRC5, THPO, CSF3R, CSF2, CSF3, CSF1
3felty's syndrome30.8CSF2, CSF3, IL3
4cyclic hematopoiesis30.8CSF2, ELANE, CSF3, IL3, CSF1
5sepsis30.6C5AR1, CSF2, CSF3, FPR1, FCGR3A, ELANE
6leukopenia30.6CSF2, CSF3, IL3, C5AR1
7thrombocytopenia30.5WAS, CSF2, CSF3, CSF1, IL3, KITLG
8severe congenital neutropenia autosomal recessive 330.5CSF3R, CSF2, CSF3, IL3, ELANE
9arthritis30.5CSF1, C5AR1, CSF2, FCGR3A
10poikiloderma with neutropenia30.5USB1
11aspergillosis30.3CSF1, ELANE
12colorectal cancer30.2KITLG, BIRC5, LEF1
13dyskeratosis congenita30.2CSF2, KITLG
14hepatitis c30.2THPO
15chronic myeloid leukemia30.1CSF3R, CSF2, CSF3, CD177, IL3, LEF1
16aplastic anemia30.1CSF2, CSF3, CSF1, IL3, THPO, KITLG
17deficiency anemia30.1CSF3R, CSF2, CSF3, IL3, KITLG, THPO
18vasculitis30.0ELANE
19rothmund-thomson syndrome30.0RECQL4
20myelodysplastic syndromes29.9KITLG, CSF3, CSF2, CSF3R, CSF1, THPO
21acute lymphocytic leukemia29.9KITLG, LEF1, IL3, CSF3, CSF2, CSF3R
22graft versus host disease29.9CSF2, CSF3, IL3
23tuberculosis29.9C5AR1, FPR1
24septic shock29.9C5AR1, ELANE, CSF3
25refractory anemia29.7CSF2, CSF3, CSF1, IL3, KITLG, THPO
26chronic myelomonocytic leukemia29.7KITLG, CSF1, CSF2, CSF3, CSF3R
27pancytopenia29.7CSF2, CSF1, CSF3, IL3, THPO
28hypersplenism29.7THPO
29nephritis29.6FCGR3A
30n syndrome10.8
31idiopathic neutropenia10.6
32acute myeloid leukemia10.4
33bacteremia10.4
34barth syndrome10.4
35severe congenital neutropenia x-linked10.3
36neutropenia, alloimmune neonatal10.3
37hematopoietic stem cell transplantation10.3
38colon lymphoma10.3
39neutropenia, severe congenital 1, autosomal dominant10.3
40systemic lupus erythematosus10.2
41invasive aspergillosis10.2
42severe congenital neutropenia autosomal dominant10.2
43severe congenital neutropenia, autosomal recessive, 410.2
44large granular lymphocyte leukemia10.2
45agammaglobulinemia10.2
46ecthyma10.1
47hepatitis a10.1
48neutropenia chronic familial10.1
49wiskott-aldrich syndrome10.1
50osteoporosis10.1

Graphical network of the top 20 diseases related to Neutropenia:



Diseases related to neutropenia

Clinical Features for Neutropenia

Drugs & Therapeutics for Neutropenia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Neutropenia

Drug clinical trials:

Search ClinicalTrials for Neutropenia

Search NIH Clinical Center for Neutropenia

Search CenterWatch for Neutropenia

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Neutropenia cell therapies at LifeMap Discovery.

Genetic Tests for Neutropenia

Anatomical Context for Neutropenia

Animal Models for Neutropenia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Neutropenia

Sources:
51PubMed
See all sources

Articles related to Neutropenia:

(show top 50)    (show all 1325)
idTitleAuthorsYear
1
Empirical Amphotericin B therapy on Day 4 or Day 8 of Febrile Neutropenia. (23844563)
2014
2
Understanding neutropenia. (24275692)
2014
3
Primary immunodeficiencies appearing as combined lymphopenia, neutropenia, and monocytopenia. (24316408)
2013
4
Severe transient neutropenia with fever and abdominal pain in a 30-year-old man. (23836852)
2013
5
Association of creatinine clearance with neutropenia in breast cancer patients undergoing chemotherapy with fluorouracil, doxorubicin, and cyclophosphamide (FAC). (23629563)
2013
6
The spectrum of ELANE mutations and their implications in severe congenital and cyclic neutropenia. (23463630)
2013
7
Management of Febrile Neutropenia in a Patient With Acute Leukemia. (24054730)
2013
8
Epidemiology of congenital neutropenia. (23351985)
2013
9
Urinary tract infections in pediatric oncology patients with fever and neutropenia. (22304012)
2012
10
Prevention and control of infections in patients with severe congenital neutropenia; a follow up study. (22427476)
2012
11
Meta-analysis of nanoparticulate paclitaxel delivery system pharmacokinetics and model prediction of associated neutropenia. (22588463)
2012
12
Lymphopenia in patients with chronic idiopathic neutropenia is associated with decreased number of T-lymphocytes containing T-cell receptor excision circles. (22092365)
2012
13
An acquired CSF3R mutation in an adult chronic idiopathic neutropenia patient who developed acute myeloid leukaemia. (22146088)
2012
14
DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma. (22047709)
2012
15
Genetic defects in severe congenital neutropenia: emerging insights into life and death of human neutrophil granulocytes. (21219176)
2011
16
Increased T regulatory cells and decreased Th1 pro-inflammatory cytokines correlate with culture-positive infection in febrile neutropenia childhood oncology patients. (21167738)
2011
17
Severe congenital neutropenia, a genetically heterogeneous disease group with an increased risk of AML/MDS. (22053285)
2011
18
Gut overgrowth of vancomycin-resistant enterococci (VRE) results in linezolid-resistant mutation in a child with severe congenital neutropenia: a case report. (17762497)
2007
19
Successful treatment of disseminated fusariosis with posaconazole during neutropenia and subsequent allogeneic hematopoietic stem cell transplantation. (17462004)
2007
20
Erythropoietin resistant anemia and neutropenia due to copper deficiency during long-term enteral nutrition on maintained hemodialysis]. (17305065)
2007
21
EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumours. (16750358)
2006
22
Severe anemia and neutropenia associated with hyperzincemia and hypercalprotectinemia. (16189440)
2005
23
Neulasta (pegfilgrastim): a once-per-cycle option for the management of chemotherapy-induced neutropenia. (15181606)
2004
24
Adhesion molecules, endogenous granulocyte colony-stimulating factor levels and replating capacity of progenitors in autoimmune neutropenia of childhood. (14696847)
2003
25
Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase. (12897784)
2003
26
Successful treatment with G-CSF and corticosteroid of adult idiopathic autoimmune neutropenia presenting as recurrent enterocolitis]. (12508486)
2002
27
Acute lymphocytic leukemia after fulminant varicella associated with severe neutropenia. (12356115)
2002
28
Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis. (12384420)
2002
29
Possibility of somatic mosaicism of ELA2 mutation overlooked in an asymptomatic father transmitting severe congenital neutropenia to two offspring. (12181069)
2002
30
Hematopoietic growth factors in prophylaxis and therapy of infections complications in children with neutropenia]. (11528556)
2001
31
Characterization of mutant neutrophil elastase in severe congenital neutropenia. (11278653)
2001
32
A randomized trial of granulocyte-macrophage colony-stimulating factor in neonates with sepsis and neutropenia. (11134431)
2001
33
Significance of neutrophil elastase mutations versus G-CSF receptor mutations for leukemic progression of congenital neutropenia. (11286224)
2001
34
Difference in the responses after administration of granulocyte colony-stimulating factor in septic patients with relative neutropenia. (10823524)
2000
35
Cancrum oris (noma) in a patient with acute lymphoblastic leukaemia. A complication of chemotherapy induced neutropenia. (9619095)
1998
36
Successful treatment of a generalized human papillomavirus infection with granulocyte-macrophage colony-stimulating factor and interferon gamma immunotherapy in a patient with a primary immunodeficiency and cyclic neutropenia. (9126013)
1997
37
Dominantly inherited severe congenital neutropenia. (8890001)
1996
38
Reduction of granulocyte activation during hemodialysis with regional citrate anticoagulation: dissociation of complement activation and neutropenia from neutrophil degranulation. (8785392)
1996
39
Severe congenital neutropenia terminating in acute myeloid leukemia: disease progression associated with mutations in the granulocyte-colony stimulating factor receptor gene. (8913314)
1996
40
Prevention of infection in a patient with chronic idiopathic neutropenia undergoing coronary bypass surgery with peri-operative G-CSF. (8996068)
1996
41
Can treatment with recombinant granulocyte colony-stimulating factor transform neutropenia into leukemia? (7472851)
1995
42
Prevention of chemotherapy-induced neutropenia using G-CSF with VACOP-B--a case report. (7510192)
1993
43
Treatment of neutropenia in Felty's syndrome with granulocyte-macrophage colony-stimulating factor--hematological response accompanied by pulmonary complications with lethal outcome. (1457582)
1992
44
Increased serum levels of granulocyte colony-stimulating factor in patients with severe congenital neutropenia. (1708293)
1991
45
Neutropenia in donor (anemic) twins involved in the twin-twin transfusion syndrome. (1770393)
1991
46
Leukopenia, neutropenia, and reduced hemoglobin levels in healthy American blacks. (2001132)
1991
47
Leukopenia with neutropenia associated with teicoplanin therapy. (2524129)
1989
48
The mechanism of neutropenia in Felty's syndrome. (4416356)
1974
49
Agammaglobulinemia, neutropenia, fever, and abdominal pain. (4697357)
1973
50
Cyclic hematopoiesis: the mechanism of cyclic neutropenia in grey collie dogs. (5054472)
1972

Genetic Variations for Neutropenia

Expression for genes affiliated with Neutropenia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Neutropenia

Search GEO for disease gene expression data for Neutropenia.

Pathways for genes affiliated with Neutropenia

Sources:
52QIAGEN, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Neutropenia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0CSF3, CSF2, CSF3R, CSF1, WAS, IL3
2
Hide members
11.0CSF3R, CSF2, CSF3, CSF1, WAS, IL3
310.9THPO, CSF3R, CSF2, CSF3, CSF1, KITLG
410.8CSF3R, CSF3, CSF1, G6PC3, IL3, KITLG
5
Hide members
10.8KITLG, IL3, CSF1, CSF3, CSF3R, CSF2
6
Hide members
10.8CSF1, THPO, CSF3R, CSF2, LEF1
7
Hide members
10.7FCGR3A, IL3, WAS, CSF2
810.7CSF3, CSF3R, CSF2, IL3
910.7KITLG, BIRC5, LEF1, CSF3R
1010.7ELANE, KITLG, LEF1
1110.7C5AR1, FCGR3A, FPR1

Compounds for genes affiliated with Neutropenia

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Neutropenia according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.8BIRC5, LEF1, FPR1, IL3, CD177, WAS
2phosphatidylinositol4511.6FPR1, THPO, CSF3R, CSF2, C5AR1, CSF1
3fmlp4511.5CSF3R, IL3, CSF1, ELANE, C5AR1, THPO
4superoxide45 2412.5CSF1, FPR1, BIRC5, KITLG, THPO, ELANE
5wortmannin4511.4CSF2, WAS, IL3, FPR1, BIRC5, C5AR1
6retinoic acid45 2412.4ELANE, IL3, CSF1, CSF3R, CSF2, THPO
7filgrastim45 1112.4KITLG, ELANE, THPO, CSF3R, CSF2, IL3
8dmso4511.4CSF2, CSF3, FPR1, BIRC5, CSF3R, KITLG
9rantes4511.4FPR1, CSF2, CSF1, CSF3, KITLG, THPO
10methylcellulose4511.3CSF3, CSF1, CSF3R, CSF2, THPO, IL3
11n-formylmethionyl-leucylphenylalanine4511.3FPR1, C5AR1, ELANE, IL3, CSF1, CSF3
12genistein45 29 60 2 11 2416.3IL3, THPO, KITLG, BIRC5, FPR1, CSF2
13hydroxyurea45 50 1113.3CSF2, THPO, KITLG, IL3, RECQL4, CSF1
14gp 1304511.3CSF3R, THPO, CSF3, CSF1, IL3, KITLG
15vegf4511.3THPO, KITLG, BIRC5, C5AR1, CSF1, CSF3
16imatinib45 50 1113.3IL3, CSF3R, KITLG, BIRC5, CSF1, THPO
17heparin45 29 11 2414.3C5AR1, THPO, FPR1, CSF1, CSF2, CSF3R
18pixy3214511.3CSF3, THPO, KITLG, IL3, CSF1, CSF2
19alanine4511.3CSF3R, FPR1, CSF1, LEF1, THPO, KITLG
205fluorouracil4511.3THPO, CSF2, CSF3, CSF1, IL3, BIRC5
21thymidine45 2412.3CSF1, IL3, CSF2, CSF3, KITLG, CSF3R
22h2o24511.2RECQL4, IL3, C5AR1, THPO, FPR1, CSF2
23daunorubicin45 50 1113.2KITLG, CSF1, IL3, CSF3, CSF2, BIRC5
24pegfilgrastim45 1112.2CSF3, ELANE, IL3, CSF2, CSF3R
25carboplatin45 50 1113.2CSF1, CSF3, THPO, KITLG, IL3, CSF2
26leukotriene b445 60 2413.2FPR1, CSF1, IL3, C5AR1, CSF2, ELANE
27mafosfamide4511.2CSF2, IL3, CSF3, KITLG, THPO
28amifostine45 1112.2CSF2, CSF3, IL3, KITLG, THPO
29cytarabine45 50 1113.2IL3, CSF1, CSF2, CSF3, KITLG, THPO
30histamine45 29 2413.2IL3, CSF2, FPR1, C5AR1, THPO, KITLG
31anaphylatoxin4511.2FPR1, ELANE, IL3, CSF2, C5AR1
32pd 98,0594511.1CSF1, C5AR1, THPO, KITLG, BIRC5, IL3
33ifosfamide45 1112.1THPO, CSF2, CSF3, CSF1, IL3
34molgramostim4511.1IL3, CSF1, CSF3, CSF2
35mitoxantrone45 50 1113.1IL3, CSF1, CSF2, BIRC5, CSF3
36cytochalasin b4511.1BIRC5, FPR1, CSF2, C5AR1, ELANE
374-hydroperoxycyclophosphamide4511.1KITLG, IL3, CSF3, CSF2
38dexamethasone45 50 29 1114.0FPR1, KITLG, IL3, BIRC5
39rituximab45 50 1113.0CSF2, CSF3, CSF1, BIRC5, FCGR3A
40gm-csf45 2912.0THPO
41aspirin45 50 29 2414.0KITLG, CSF1, ELANE, CSF2, THPO, BIRC5
42endotoxin4510.9FPR1, CSF3, CSF3R
43bryostatin 14510.9BIRC5, IL3, CSF2, CSF1
44zidovudine45 1111.8CSF1, CSF2, KITLG, CSF3, IL3
45agar4510.8IL3, BIRC5, CSF1, CSF2, THPO, KITLG
46daniplestim4510.8KITLG, IL3, CSF3
47valine4510.8ELANE, IL3
48ltc44510.7IL3, CSF2, C5AR1, CSF1
49pyronin y4510.6KITLG, BIRC5, THPO
50pge24510.4BIRC5, FPR1, CSF2

GO Terms for genes affiliated with Neutropenia

Sources:
16Gene Ontology
See all sources

Cellular components related to Neutropenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.8THPO, KITLG, IL3, CSF1, CSF3, CSF2

Biological processes related to Neutropenia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.1C5AR1, CSF2, CSF3, WAS, IL3, FCGR3A
2positive regulation of cell proliferationGO:00828411.0CSF3, BIRC5, LEF1, IL3, CSF1, CSF2
3positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.9IL3, HAX1, CSF3, KITLG
4cellular response to cytokine stimulusGO:07134510.9HAX1, LEF1, CSF3
5positive regulation of DNA replicationGO:04574010.8KITLG, IL3, CSF2
6cellular response to lipopolysaccharideGO:07122210.7CSF3, CSF2, GFI1
7positive regulation of granulocyte differentiationGO:03085410.7HAX1, LEF1
8positive regulation of actin cytoskeleton reorganizationGO:200025110.6HAX1, CSF3
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.6IL3, CSF2
10positive regulation of Ras protein signal transductionGO:04657910.5CSF1, KITLG
11positive regulation of macrophage derived foam cell differentiationGO:01074410.3CSF2, CSF1

Molecular functions related to Neutropenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.7CSF2, CSF3, CSF1, IL3, KITLG, THPO
2N-formyl peptide receptor activityGO:00498210.6FPR1, C5AR1
3cytokine activityGO:00512510.5CSF2, CSF3, CSF1, IL3, KITLG, THPO

Products for genes affiliated with Neutropenia

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Sources for Neutropenia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet