MCID: NTR004
MIFTS: 56

Neutropenia malady

Genetic diseases, Rare diseases, Blood diseases, Cancer diseases categories

Aliases & Classifications for Neutropenia

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Neutropenia, Aliases & Descriptions:

Name: Neutropenia 30 9 11 43 3 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Blood diseases


External Ids:

Disease Ontology9 DOID:1227
ICD9CM27 288.00, 288.0
MeSH33 D009503

Summaries for Neutropenia

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Wikipedia:63 Neutropenia or neutropaenia, from Latin prefix neutro- (\"neither\", for neutral staining) and Greek... more...

MalaCards based summary: Neutropenia is related to severe congenital neutropenia and felty's syndrome. An important gene associated with Neutropenia is GFI1 (growth factor independent 1 transcription repressor), and among its related pathways are Selected targets of C EBPalpha and Transcriptional misregulation in cancer. The drugs itraconazole and immunoglobulins, intravenous and the compounds bmmp and pkh 2 have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, myeloid and bone, and related mouse phenotypes are tumorigenesis and cellular.

Related Diseases for Neutropenia

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Diseases in the Neutropenia family:

Neutropenia, Severe Congenital, 5, Autosomal Recessive Neutropenia, Severe Congenital, 6, Autosomal Recessive
Neutropenia, Severe Congenital 2, Autosomal Dominant Neutropenia, Severe Congenital 3, Autosomal Recessive
Neutropenia, Severe Congenital 4, Autosomal Recessive Neutropenia, Severe Congenital 1, Autosomal Dominant
Severe Congenital Neutropenia Elane-Related Neutropenia
Neutropenia Chronic Familial Severe Congenital Neutropenia Autosomal Dominant
Gata1-Related Neutropenia

Diseases related to Neutropenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 362)
idRelated DiseaseScoreTop Affiliating Genes
1severe congenital neutropenia31.8ELANE, IL3, CSF2, CSF3R
2felty's syndrome31.3CSF2, IL3
3neutropenia, cyclic31.3ELANE, CSF2, IL3
4leukemia30.6THPO, KITLG, CSF2, CD177, GFI1, CSF3R
5dyskeratosis congenita30.5CSF2, KITLG
6myeloid leukemia30.4CSF3R, IL3, ELANE, THPO, CSF2, KITLG
7primary immunodeficiency disease30.4WAS
8rheumatoid arthritis30.3THPO, FCGR3A, ELANE, CSF2
9hypersplenism30.3THPO
10thrombocytopenia30.3KITLG, CSF2, IL3, WAS, THPO, FCGR3A
11pancytopenia30.2THPO, IL3, CSF2
12myelofibrosis30.1THPO, IL3
13granulocytopenia30.1CSF2, IL3
14aplastic anemia30.1THPO, CSF2, IL3, KITLG
15acute leukemia30.0KITLG, CSF2, IL3, THPO, CSF3R
16myelodysplastic syndrome30.0CSF2, IL3, CD177, KITLG, THPO, CSF3R
17chronic myelomonocytic leukemia30.0CSF3R, KITLG, CSF2
18chronic lymphocytic leukemia29.9THPO, CSF2, CSF3R
19fanconi anemia, complementation group a29.9KITLG, THPO, IL3
20refractory anemia29.7THPO, IL3, CSF2, KITLG
21idiopathic neutropenia10.7
22poikiloderma with neutropenia10.6
23breast cancer10.5
24lung cancer10.5
25neutropenia, severe congenital 3, autosomal recessive10.5
26barth syndrome10.5
27bacteremia10.5
28leukopenia10.4
29neutropenia, severe congenital, x-linked10.4
30arthritis10.4
31wegener granulomatosis10.4ELANE
32leukemoid reaction10.4CSF2, IL3
33neutropenia, severe congenital 1, autosomal dominant10.3
34glycogen storage disease10.3
35hematopoietic stem cell transplantation10.3
36hepatitis10.3
37lymphopenia10.3
38capillary leak syndrome10.3ELANE, CSF2
39thrombocytopenia, x-linked10.3THPO, WAS
40thrombocytopenia, congenital amegakaryocytic10.3IL3, THPO
41periodontitis10.3
42neutropenia, nonimmune chronic idiopathic, of adults10.3
43systemic lupus erythematosus10.3
44aspergillosis10.3
45lupus erythematosus10.3
46neutropenia, severe congenital 2, autosomal dominant10.3
47hodgkin lymphoma10.3
48hepatitis c10.3
49myopathy10.3
50large granular lymphocyte leukemia10.3

Graphical network of the top 20 diseases related to Neutropenia:



Diseases related to neutropenia

Symptoms for Neutropenia

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Drugs & Therapeutics for Neutropenia

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Drug clinical trials:

Search ClinicalTrials for Neutropenia

Search NIH Clinical Center for Neutropenia

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Neutropenia cell therapies at LifeMap Discovery.

Genetic Tests for Neutropenia

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Anatomical Context for Neutropenia

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MalaCards organs/tissues related to Neutropenia:

31
Neutrophil, Myeloid, Bone, Lung, Breast, Bone marrow, T cells, B cells, Skin, Liver, Monocytes, Kidney, Brain, Whole blood, Spleen, Smooth muscle, Pancreas, Prostate, Tonsil, Endothelial

Animal Models for Neutropenia or affiliated genes

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MGI Mouse Phenotypes related to Neutropenia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5KITLG, CSF2, IL3, ELANE, WAS
2MP:00053848.4HAX1, GFI1, WAS, IL3, CSF2, CSF3R
3MP:00053977.2FCGR3A, GFI1, KITLG, CSF3R, CSF2, THPO
4MP:00053877.1THPO, GFI1, FCGR3A, G6PC3, KITLG, CSF3R

Publications for Neutropenia

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Articles related to Neutropenia:

(show top 50)    (show all 1411)
idTitleAuthorsYear
1
Methimazole associated neutropenia in a preterm neonate treated for hyperthyroidism. (25810932)
2015
2
Recurrent Dermatophytosis (Majocchi granuloma) Associated With Chemotherapy-Induced Neutropenia. (24470005)
2014
3
Intermittent neutropenia as an early feature of mild mevalonate kinase deficiency. (24177804)
2014
4
Tacrolimus-induced neutropenia in a cardiac transplant patient. (24384051)
2014
5
A case of endogenous endophthalmitis complicated by neutropenia following bacteremia with Streptococcus mitis resistant to beta-lactam antibiotics. (22830590)
2013
6
Continuation of Deferiprone Therapy in Patients with Mild Neutropenia May Not Lead to a More Severe Drop in Neutrophil Count. (24330079)
2013
7
Comparative effectiveness of pegfilgrastim, filgrastim, and sargramostim prophylaxis for neutropenia-related hospitalization: two US retrospective claims analyses. (23016568)
2013
8
Cost-effectiveness of filgrastim and pegfilgrastim as primary prophylaxis against febrile neutropenia in lymphoma patients. (23873405)
2013
9
Treatment of fungal disease in the setting of neutropenia. (24319214)
2013
10
Squamous cell carcinoma in a child with Clericuzio-type poikiloderma with neutropenia. (22924337)
2013
11
Prospective randomized study of cefepime, panipenem, or meropenem monotherapy for patients with hematological disorders and febrile neutropenia. (22948387)
2013
12
External validation of a risk model of febrile neutropenia occurrence in patients with non-Hodgkin lymphoma. (23452152)
2013
13
Lenograstim in preventing chemotherapy-induced febrile neutropenia in patients with soft tissue sarcoma. (23393367)
2013
14
Urinary tract infections in pediatric oncology patients with fever and neutropenia. (22304012)
2012
15
A novel compound heterozygous HAX1 mutation in a Chinese patient with severe congenital neutropenia and chronic myelomonocytic leukemia transformation but without neurodevelopmental abnormalities. (22102707)
2012
16
The diagnostic value of interleukin-6 and interleukin-8 for early prediction of bacteremia and sepsis in children with febrile neutropenia and cancer. (22367386)
2012
17
Guidelines for pediatric management of severe chronic neutropenia. (22237723)
2012
18
A cost analysis of febrile neutropenia management in Australia: ambulatory v. in-hospital treatment. (22126955)
2011
19
Extended-interval aminoglycoside therapy for adult patients with febrile neutropenia: a systematic review. (22479053)
2011
20
Single nucleotide polymorphisms in the human TNF gene are associated with anaemia and neutropenia in a cohort of patients with de novo myelodysplastic syndrome. (20618340)
2010
21
Targeted next-generation sequencing appoints c16orf57 as clericuzio- type poikiloderma with neutropenia gene. (20004881)
2010
22
Mutations in C16orf57 and normal-length telomeres unify a subset of patients with dyskeratosis congenita, poikiloderma with neutropenia and Rothmund-Thomson syndrome. (20817924)
2010
23
Dose-dependent risk of neutropenia after 7-day courses of artesunate monotherapy in Cambodian patients with acute Plasmodium falciparum malaria. (21070142)
2010
24
A syndrome with congenital neutropenia and mutations in G6PC3. (19118303)
2009
25
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
26
The effect of granulocyte colony-stimulating factor (G-CSF) on the activity of granulocyte enzymes in children with cancer who developed neutropenia after chemotherapy. (18614436)
2008
27
Severe congenital neutropenia: new genes explain an old disease. (17917547)
2007
28
Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. (16584360)
2006
29
Severe congenital neutropenia: genetics and pathogenesis. (18528462)
2006
30
The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy. (16497969)
2006
31
Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia. (16391909)
2006
32
Severe neutropenia in Japanese patients with x-linked agammaglobulinemia. (16160918)
2005
33
Cyclic neutropenia with anti-NA2 antibodies and treatment with recombinant granulocyte colony-stimulating factor]. (16045884)
2005
34
The role of colony-stimulating factors and granulocyte transfusion in treatment options for neutropenia in children with cancer. (14510625)
2003
35
Acute lymphocytic leukemia after fulminant varicella associated with severe neutropenia. (12940335)
2003
36
Resistance to recombinant human granulocyte colony-stimulating factor in neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies. (11927737)
2002
37
Clinical implications of mutations of neutrophil elastase in congenital and cyclic neutropenia. (11846296)
2001
38
Spontaneous remission of granulocyte colony-stimulating factor-associated leukemia in a child with severe congenital neutropenia. (11071667)
2000
39
Granulocyte colony-stimulating factor receptor mutations in severe congenital neutropenia transforming to acute myelogenous leukemia confer resistance to apoptosis and enhance cell survival. (10706885)
2000
40
Prophylactic administration of granulocyte colony-stimulating factor when monocytopenia appears lessens neutropenia caused by chemotherapy for lung cancer. (10857893)
2000
41
Serum granulocyte colony-stimulating factor levels in patients with chronic neutropenia of childhood: modulation of G-CSF levels by myeloid precursor cell mass. (10233425)
1999
42
Dominantly inherited severe congenital neutropenia. (8890001)
1996
43
Reduction of granulocyte activation during hemodialysis with regional citrate anticoagulation: dissociation of complement activation and neutropenia from neutrophil degranulation. (8785392)
1996
44
The effect of continuous G-CSF application in human cyclic neutropenia: a model analysis. (7540416)
1995
45
Contrasting effects of recombinant human granulocyte-macrophage colony-stimulating factor (CSF) and granulocyte CSF treatment on the cycling of blood elements in childhood-onset cyclic neutropenia. (7519479)
1994
46
C-reactive protein: a valuable aid for the management of febrile children with cancer and neutropenia. (8038314)
1994
47
Intervention treatment of established neutropenia with human recombinant granulocyte-macrophage colony-stimulating factor (rhGM-CSF) in patients undergoing cancer chemotherapy. (8429694)
1993
48
Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkin's lymphoma: a randomized controlled trial. (1381626)
1992
49
Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia. (1978690)
1990
50
Glycogenosis type Ib complicated by severe granulocytopenia resembling inherited neutropenia. (6944203)
1981

Variations for Neutropenia

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Expression for genes affiliated with Neutropenia

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Search GEO for disease gene expression data for Neutropenia.

Pathways for genes affiliated with Neutropenia

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Pathways related to Neutropenia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL3, ELANE, CSF2
2
Show member pathways
Type III interferon signaling36
9.6IL3, CSF3R, CSF2
3
Show member pathways
9.3THPO, IL3, KITLG
4
Show member pathways
Immune response CD16 signaling in NK cells58
9.2FCGR3A, WAS, IL3, CSF2
59.2KITLG, IL3, CSF3R, G6PC3
6
Show member pathways
8.7CSF2, IL3, THPO, KITLG, CSF3R
78.7IL3, CSF2, CSF3R, KITLG, THPO
8
Show member pathways
8.4IL3, THPO, WAS, CSF2, CSF3R, KITLG
9
Show member pathways
8.4IL3, CSF2, KITLG, CSF3R, WAS, THPO

Compounds for genes affiliated with Neutropenia

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Compounds related to Neutropenia according to GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1bmmp4310.2CSF2, IL3
2pkh 24310.1IL3, KITLG
3daniplestim4310.0IL3, KITLG
4molgramostim4310.0CSF2, IL3
5anaphylatoxin4310.0ELANE, IL3, CSF2
6pyronin y439.9KITLG, THPO
7n-formylmethionyl-leucylphenylalanine439.8CSF2, ELANE, IL3
8ifosfamide43 1210.8IL3, THPO, CSF2
9pegfilgrastim43 1210.8CSF3R, IL3, ELANE, CSF2
104-hydroperoxycyclophosphamide439.8KITLG, IL3, CSF2
11as 10143 5910.8KITLG, IL3, CSF2
12leucovorin43 49 1211.7IL3, THPO, CSF2
13a23187439.7CSF2, IL3
14ivig439.7CSF2, IL3, FCGR3A
15neopterin439.7CSF2, IL3, ELANE
16valine439.7CSF2, FCGR3A, ELANE, IL3
17hydrocortisone43 2 59 1212.5CSF2, KITLG, IL3, ELANE
18mesna439.5CSF2, IL3
19calcitriol43 59 24 1212.5GFI1, IL3, CSF2, KITLG
20imatinib43 49 1211.5KITLG, IL3, THPO, CSF3R
21herbimycin a43 5910.5FCGR3A, CSF2, IL3, KITLG
22mafosfamide439.4CSF2, IL3, THPO, KITLG
23pixy321439.4THPO, IL3, CSF2, KITLG
24amifostine43 1210.4THPO, KITLG, IL3, CSF2
25carboplatin43 49 1211.4KITLG, CSF2, IL3, THPO
26hydroxyurea43 49 1211.4CSF2, KITLG, THPO, IL3
27dmso439.4THPO, CSF2, CSF3R, KITLG
28aspirin43 49 28 2412.4THPO, CSF2, KITLG, ELANE
29cytarabine43 49 1211.4THPO, KITLG, CSF2, IL3
30daunorubicin43 49 1211.4KITLG, CSF2, IL3
315fluorouracil439.3THPO, IL3, KITLG, CSF2
32agar439.2KITLG, CSF2, IL3, THPO
33rantes439.2THPO, IL3, KITLG, CSF2
34gm-csf43 2810.2ELANE, THPO, IL3, CSF2, KITLG
35superoxide43 2410.2CSF3R, KITLG, THPO, ELANE, CSF2
36methylcellulose439.2CSF2, THPO, IL3, CSF3R, KITLG
37gp 130439.2THPO, IL3, CSF2, CSF3R, KITLG
38lactate439.1IL3, ELANE, KITLG, CSF2, THPO
39fmlp439.1THPO, FCGR3A, ELANE, IL3, CSF3R, CSF2
40genistein43 28 59 2 24 1214.1CSF2, IL3, KITLG, CSF3R, THPO
41wortmannin439.1WAS, IL3, CSF2, KITLG, THPO
42thymidine43 2410.1CSF3R, IL3, KITLG, CSF2, THPO
43butyrate439.0CSF2, KITLG, THPO, IL3
44polysaccharide439.0CSF2, KITLG, THPO, IL3
45filgrastim43 1210.0CSF3R, KITLG, CSF2, IL3, ELANE, THPO
46heparin43 28 24 1211.9IL3, CSF3R, CSF2, KITLG, ELANE, THPO
47h2o2438.9IL3, ELANE, CSF2, KITLG, THPO
48retinoic acid43 249.8THPO, ELANE, KITLG, CSF3R, CSF2, IL3
49phosphatidylinositol438.6CSF2, WAS, THPO, IL3, KITLG, FCGR3A
50tyrosine438.3CD177, KITLG, CSF3R, IL3, CSF2, WAS

GO Terms for genes affiliated with Neutropenia

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Cellular components related to Neutropenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.6KITLG, CSF3R, CSF2, IL3, ELANE, FCGR3A

Biological processes related to Neutropenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.7CSF2, IL3
2embryonic hemopoiesisGO:00351629.7KITLG, IL3
3positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.5HAX1, IL3, KITLG
4positive regulation of DNA replicationGO:00457409.5IL3, CSF2, KITLG
5immune responseGO:00069559.2CSF2, IL3, WAS, FCGR3A
6blood coagulationGO:00075968.8THPO, CD177, WAS, VPS45

Molecular functions related to Neutropenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0KITLG, CSF2, IL3, THPO
2growth factor activityGO:00080838.7KITLG, CSF2, IL3, THPO

Products for genes affiliated with Neutropenia

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Sources for Neutropenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet