MCID: NTR004
MIFTS: 65

Neutropenia malady

Summaries for Neutropenia

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3CDC, 63Wikipedia, 32MalaCards
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CDC:3 People receiving chemotherapy are at risk for developing an infection when their white blood cell count is low. White blood cells are the body's main defense against infection. This condition, called neutropenia, is common after receiving chemotherapy. For patients with this condition, any infection can become serious quickly.

MalaCards: Neutropenia is related to severe congenital neutropenia and leukemia. An important gene associated with Neutropenia is GFI1 (growth factor independent 1 transcription repressor), and among its related pathways are PAK Pathway and Akt Signaling. The drugs immunoglobulins, intravenous and ciprofloxacin and the compounds tyrosine and phosphatidylinositol have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and lung, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:63 Neutropenia, occasionally spelled neutropaenia or neutropoenia, from Latin prefix neutro- (neither, for... more...

Aliases & Classifications for Neutropenia

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

neutropenia 8 10 44 30 60


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Disease Ontology8 DOID:1227
MeSH34 D009503
ICD9CM27 288.00, 288.0

Related Diseases for Neutropenia

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17GeneCards, 18GeneDecks
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Diseases in the Severe Congenital Neutropenia family:

neutropenia Elane-Related Neutropenia
Neutropenia Chronic Familial Gata1-Related Neutropenia

Diseases related to Neutropenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 320)
idRelated DiseaseScoreTop Affiliating Genes
1severe congenital neutropenia31.4IL3, LEF1, BIRC5, KITLG, GFI1, THPO
2leukemia31.0CSF3R, CSF2, CSF3, CSF1, CD177, RECQL4
3acute leukemia30.8CSF3R, CSF2, CSF3, CSF1, IL3, BIRC5
4felty's syndrome30.8CSF2, CSF3, IL3
5cyclic hematopoiesis30.8CSF2, CSF3, CSF1, IL3, ELANE
6breast cancer30.7CSF3R, CSF2, CSF3, CSF1, LEF1, BIRC5
7lung cancer30.6CSF2, CSF3, BIRC5
8myeloid leukemia30.6CSF3R, CSF2, CSF3, CSF1, IL3, FPR1
9thrombocytopenia30.5CSF2, CSF3, CSF1, WAS, IL3, KITLG
10severe congenital neutropenia autosomal recessive 330.5IL3, CSF3, CSF2, CSF3R, ELANE
11arthritis30.4C5AR1, FCGR3A, CSF1, CSF2
12poikiloderma with neutropenia30.4USB1
13glycogen storage disease30.4CSF3
14rheumatoid arthritis30.4CSF2, CSF1, FCGR3A, THPO, C5AR1, ELANE
15aspergillosis30.3ELANE, CSF1
16hepatitis c30.2THPO
17non-hodgkin lymphoma30.2CSF2, CSF3, IL3, BIRC5, KITLG, FCGR3A
18colorectal cancer30.2KITLG, BIRC5, LEF1
19pancreatitis30.2ELANE, KITLG
20pneumonia30.2CSF2, CSF3, C5AR1, ELANE
21dyskeratosis congenita30.1KITLG, CSF2
22chronic myeloid leukemia30.1CSF3R, CSF2, CSF3, CD177, IL3, LEF1
23aplastic anemia30.1CSF2, CSF3, CSF1, IL3, KITLG, THPO
24myeloma30.1CSF2, CSF3, CSF1, IL3, BIRC5, KITLG
25deficiency anemia30.1CSF3R, CSF2, CSF3, IL3, KITLG, THPO
26sarcoma30.1CSF1, KITLG, THPO
27multiple myeloma30.1CSF3
28vasculitis30.0ELANE
29rothmund-thomson syndrome30.0RECQL4
30hematologic cancer29.8CSF3R, CSF2, CSF3, CSF1, IL3, BIRC5
31acute lymphocytic leukemia29.8CSF3R, CSF2, CSF3, IL3, LEF1, KITLG
32chronic lymphocytic leukemia29.8CSF3R, CSF2, LEF1, BIRC5, THPO
33melanoma29.8CSF3R, CSF2, CSF1, LEF1, BIRC5, KITLG
34multiple sclerosis29.8CSF1, KITLG, THPO
35graft versus host disease29.8IL3, CSF3, CSF2
36tuberculosis29.8FPR1, C5AR1
37pancytopenia29.6CSF2, CSF3, CSF1, IL3, THPO
38monocytic leukemia29.6CSF1, CSF2, CSF3R
39non-small cell lung carcinoma29.6CSF2, CSF3, IL3, BIRC5, THPO
40neuroblastoma29.6CD177
41hypersplenism29.6THPO
42glomerulonephritis29.6ELANE, C5AR1
43purpura29.6THPO
44pancreatic cancer29.6BIRC5
45myelofibrosis29.6THPO, CD177
46prostate cancer29.6CSF3R, BIRC5, GFI1
47encephalitis29.6C5AR1
48acute myeloid leukemia10.4
49barth syndrome10.4
50idiopathic neutropenia10.4

Graphical network of the top 20 diseases related to Neutropenia:



Diseases related to neutropenia

Clinical Features for Neutropenia

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Drugs & Therapeutics for Neutropenia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Neutropenia

Drug clinical trials:

Search ClinicalTrials for Neutropenia

Search NIH Clinical Center for Neutropenia

Search CenterWatch for Neutropenia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Neutropenia cell therapies at LifeMap Discovery.

Genetic Tests for Neutropenia

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Anatomical Context for Neutropenia

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32MalaCards
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MalaCards organs/tissues related to Neutropenia:

32
Myeloid, Bone, Lung, Breast, Bone marrow, T cells, Skin, B cells, Monocytes, Liver, Kidney, Brain, Prostate, Pancreas, Smooth muscle, Endothelial, Spleen, Whole blood, Tonsil

Animal Models for Neutropenia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neutropenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.8ELANE, CSF3R, CSF2, CSF3, CSF1, WAS
2MP:000539711.6G6PC3, HAX1, WAS, CSF1, CSF3, CSF2
3MP:001076811.4CSF2, CSF1, HAX1, G6PC3, RECQL4, IL3
4MP:000538411.2CSF3R, CSF2, CSF1, WAS, HAX1, RECQL4
5MP:000537611.1CSF1, WAS, G6PC3, IL3, BIRC5, KITLG
6MP:000539011.0CSF2, CSF1, WAS, HAX1, RECQL4, LEF1
7MP:000537910.8CSF2, CSF1, WAS, IL3, FPR1, LEF1
8MP:000200610.4WAS, RECQL4, KITLG, ELANE

Publications for Neutropenia

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50PubMed
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Articles related to Neutropenia:

(show top 50)    (show all 1325)
idTitleAuthorsYear
1
Tacrolimus-induced neutropenia in a cardiac transplant patient. (24384051)
2014
2
Can we safely discharge low-risk patients with febrile neutropenia from the emergency department? (23876828)
2014
3
Late-onset neutropenia: defining limits of neutrophil count in very low birth weight infants. (24030676)
2014
4
Primary granulocyte colony-stimulating factor prophylaxis during the first two cycles only or throughout all chemotherapy cycles in patients with breast cancer at risk for febrile neutropenia. (23630211)
2013
5
The use of FDG-PET/CT in patients with febrile neutropenia. (23905616)
2013
6
Piperacillin/tazobactam vs. cefoperazone/sulbactam in adult low-risk febrile neutropenia cases. (24372736)
2013
7
Etiology, clinical outcome, and laboratory features in children with neutropenia: Analysis of 104 cases. (24325465)
2013
8
Breakthrough febrile neutropenia and associated complications among elderly cancer patients receiving myelosuppressive chemotherapy for solid tumors and lymphomas. (23471537)
2013
9
Moxifloxacin is more effective than tosufloxacin in reducing chemotherapy-induced febrile neutropenia in patients with hematological malignancies. (22978686)
2013
10
Neutropenia during therapy with peginterferon and ribavirin in HIV-infected subjects with chronic hepatitis C and the risk of infections. (23575196)
2013
11
UGT1A1*6, 1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI-treated metastatic colorectal cancer in two prospective studies in Japan. (24033692)
2013
12
Chemotherapy-Induced Neutropenia in HIV Positive Patients with Lymphoma: Comparison of Pegfilgrastim with Daily Filgrastim Administration. (23170191)
2012
13
Identification of educational and infrastructural barriers to prompt antibiotic delivery in febrile neutropenia: a quality improvement initiative. (22147665)
2012
14
Simultaneous occurrence of foetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies: a case study and review of the literature. (22537228)
2012
15
Emergence of multidrug resistant acinetobacter blood stream infections in febrile neutropenia patients with haematological cancers and bone marrow failure syndromes. (23520666)
2012
16
Drug interactions between micafungin at high doses and cyclosporine A in febrile neutropenia patients after allogeneic hematopoietic stem cell transplantation. (22943928)
2012
17
Guideline for the management of fever and neutropenia in children with cancer and/or undergoing hematopoietic stem-cell transplantation. (22987086)
2012
18
Severe periodontitis in a patient with cyclic neutropenia: a case report of long-term follow-up. (23509838)
2012
19
Use of antibacterial prophylaxis in patients with chemotherapy-induced neutropenia. (22080847)
2012
20
Extended-interval aminoglycoside therapy for adult patients with febrile neutropenia: a systematic review. (22479053)
2011
21
Disseminated cryptococcosis in a non-Hodgkin's lymphoma patient with late-onset neutropenia following rituximab-CHOP chemotherapy: a case report and literature review. (21472389)
2011
22
High-dose dexamethasone therapy for severe thrombocytopenia and neutropenia induced by EBV infectious mononucleosis. (20082159)
2010
23
Clinical implications of ELA2-, HAX1-, and G-CSF-receptor (CSF3R) mutations in severe congenital neutropenia. (19120359)
2009
24
Novel genetic etiologies of severe congenital neutropenia. (19782549)
2009
25
Image of the month. Albinism, cyclic neutropenia, and ceroid pigment in the liver. (19554547)
2009
26
Survivin expression in the bone marrow of patients with severe congenital neutropenia. (18818705)
2009
27
Is pegfilgrastim safe and effective in congenital neutropenia? An analysis of the French Severe Chronic Neutropenia registry. (19618456)
2009
28
Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean. (18710383)
2008
29
Isolated chronic severe neutropenia in eosinophilic fasciitis. Failure of response to granulacyte colony-stimulating factor. (17418006)
2007
30
Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. (16584360)
2006
31
A family of severe congenital neutropenia with -199C to A substitution in ELA2 promoter. (16795059)
2006
32
Dose and outcome: the hurdle of neutropenia (Review). (16820898)
2006
33
Strong evidence for autosomal dominant inheritance of severe congenital neutropenia associated with ELA2 mutations. (16737875)
2006
34
Analysis of risk factors for myelodysplasias, leukemias and death from infection among patients with congenital neutropenia. Experience of the French Severe Chronic Neutropenia Study Group. (15642668)
2005
35
Optimizing the management of chemotherapy-induced neutropenia. (16258470)
2003
36
Severe autoimmune neutropenia associated with bone marrow sea-blue histiocytosis. (12199768)
2002
37
Low Fcgamma receptor III and high granulocyte colony-stimulating factor serum levels correlate with the risk of infection in neutropenia due to Felty's syndrome or systemic lupus erythematosus. (12133752)
2002
38
Invasive pulmonary aspergillosis resulting in respiratory failure during neutrophil recovery from postchemotherapy neutropenia in three patients with acute leukaemia. (12190893)
2002
39
Febrile neutropenia, colony-stimulating factors and therapy: time for a new methodology? (11904781)
2002
40
Patients with chronic idiopathic neutropenia of adults have increased serum concentrations of inflammatory cytokines and chemokines. (11074551)
2000
41
Abnormalities of primitive myeloid progenitor cells expressing granulocyte colony-stimulating factor receptor in patients with severe congenital neutropenia. (11110716)
2000
42
Defective internalization and sustained activation of truncated granulocyte colony-stimulating factor receptor found in severe congenital neutropenia/acute myeloid leukemia. (9885206)
1999
43
Dissociation between complement activation, integrin expression and neutropenia during hemodialysis. (10514074)
1999
44
Successful treatment of pustulosis palmaris et plantaris with granulocyte colony stimulating factor in a patient with hereditary neutropenia. (9885446)
1998
45
Treatment of chronic neutropenia associated with large granular lymphocytosis with cyclosporine A and filgrastim. (7485104)
1995
46
Use of granulocyte-macrophage colony-stimulating factor for reversal of neutropenia following combined kidney-pancreas transplantation. (8539860)
1995
47
Antibiotic strategy in orofacial/head and neck infections in severe neutropenia. (8015798)
1994
48
Abnormal responses of myeloid progenitor cells to recombinant human colony-stimulating factors in congenital neutropenia. (1693298)
1990
49
Effect of granulocyte-macrophage colony-stimulating factor on neutropenia and related morbidity induced by myelotoxic chemotherapy. (2182461)
1990
50
Primary splenic neutropenia with rheumatoid arthritis. (Felty's syndrome). (15427053)
1950

Genetic Variations for Neutropenia

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Expression for genes affiliated with Neutropenia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neutropenia

Search GEO for disease gene expression data for Neutropenia.

Pathways for genes affiliated with Neutropenia

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51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Neutropenia according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0CSF3R, CSF2, CSF3, CSF1, WAS, IL3
2
Hide members
11.0CSF3R, CSF2, CSF3, CSF1, WAS, IL3
310.9THPO, CSF3R, CSF2, CSF3, CSF1, IL3
410.8CSF3R, CSF3, CSF1, G6PC3, IL3, KITLG
5
Hide members
10.8CSF3R, CSF2, CSF3, CSF1, IL3, KITLG
6
Hide members
10.8CSF3R, CSF2, CSF1, LEF1, THPO
7
Hide members
10.7FCGR3A, IL3, WAS, CSF2
810.7IL3, CSF3, CSF2, CSF3R
910.7KITLG, BIRC5, LEF1, CSF3R
1010.7LEF1, KITLG, ELANE
1110.7C5AR1, FCGR3A, FPR1

Compounds for genes affiliated with Neutropenia

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
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Compounds related to Neutropenia according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.8BIRC5, LEF1, FPR1, IL3, CD177, WAS
2phosphatidylinositol4411.6FPR1, THPO, CSF3R, CSF2, C5AR1, CSF1
3fmlp4411.5CSF3R, IL3, CSF1, ELANE, C5AR1, THPO
4superoxide44 2412.5CSF1, FPR1, BIRC5, KITLG, THPO, ELANE
5wortmannin4411.4CSF2, WAS, IL3, FPR1, BIRC5, C5AR1
6retinoic acid44 2412.4ELANE, IL3, CSF1, CSF3R, CSF2, THPO
7filgrastim44 1112.4KITLG, ELANE, THPO, CSF3R, CSF2, IL3
8dmso4411.4CSF2, CSF3, FPR1, BIRC5, CSF3R, KITLG
9rantes4411.4FPR1, CSF2, CSF1, CSF3, KITLG, THPO
10methylcellulose4411.3CSF3, CSF1, CSF3R, CSF2, THPO, IL3
11n-formylmethionyl-leucylphenylalanine4411.3FPR1, C5AR1, ELANE, IL3, CSF1, CSF3
12genistein44 28 59 2 11 2416.3IL3, THPO, KITLG, BIRC5, FPR1, CSF2
13hydroxyurea44 49 1113.3CSF2, THPO, KITLG, IL3, RECQL4, CSF1
14gp 1304411.3CSF3R, THPO, CSF3, CSF1, IL3, KITLG
15vegf4411.3THPO, KITLG, BIRC5, C5AR1, CSF1, CSF3
16imatinib44 49 1113.3IL3, CSF3R, KITLG, BIRC5, CSF1, THPO
17heparin44 28 11 2414.3C5AR1, THPO, FPR1, CSF1, CSF2, CSF3R
18pixy3214411.3CSF3, THPO, KITLG, IL3, CSF1, CSF2
19alanine4411.3CSF3R, FPR1, CSF1, LEF1, THPO, KITLG
205fluorouracil4411.3THPO, CSF2, CSF3, CSF1, IL3, BIRC5
21thymidine44 2412.3CSF1, IL3, CSF2, CSF3, KITLG, CSF3R
22h2o24411.2RECQL4, IL3, C5AR1, THPO, FPR1, CSF2
23daunorubicin44 49 1113.2KITLG, CSF1, IL3, CSF3, CSF2, BIRC5
24pegfilgrastim44 1112.2CSF3, ELANE, IL3, CSF2, CSF3R
25carboplatin44 49 1113.2CSF1, CSF3, THPO, KITLG, IL3, CSF2
26leukotriene b444 59 2413.2FPR1, CSF1, IL3, C5AR1, CSF2, ELANE
27mafosfamide4411.2CSF2, IL3, CSF3, KITLG, THPO
28amifostine44 1112.2CSF2, CSF3, IL3, KITLG, THPO
29cytarabine44 49 1113.2IL3, CSF1, CSF2, CSF3, KITLG, THPO
30histamine44 28 2413.2IL3, CSF2, FPR1, C5AR1, THPO, KITLG
31anaphylatoxin4411.2FPR1, ELANE, IL3, CSF2, C5AR1
32pd 98,0594411.1CSF1, C5AR1, THPO, KITLG, BIRC5, IL3
33ifosfamide44 1112.1THPO, CSF2, CSF3, CSF1, IL3
34molgramostim4411.1IL3, CSF1, CSF3, CSF2
35mitoxantrone44 49 1113.1IL3, CSF1, CSF2, BIRC5, CSF3
36cytochalasin b4411.1BIRC5, FPR1, CSF2, C5AR1, ELANE
374-hydroperoxycyclophosphamide4411.1KITLG, IL3, CSF3, CSF2
38dexamethasone44 49 28 1114.0FPR1, KITLG, IL3, BIRC5
39rituximab44 49 1113.0CSF2, CSF3, CSF1, BIRC5, FCGR3A
40gm-csf44 2812.0THPO
41aspirin44 49 28 2414.0KITLG, CSF1, ELANE, CSF2, THPO, BIRC5
42endotoxin4410.9FPR1, CSF3, CSF3R
43bryostatin 14410.9BIRC5, IL3, CSF2, CSF1
44zidovudine44 1111.8CSF1, CSF2, KITLG, CSF3, IL3
45agar4410.8IL3, BIRC5, CSF1, CSF2, THPO, KITLG
46daniplestim4410.8KITLG, IL3, CSF3
47valine4410.8ELANE, IL3
48ltc44410.7IL3, CSF2, C5AR1, CSF1
49pyronin y4410.6KITLG, BIRC5, THPO
50pge24410.4BIRC5, FPR1, CSF2

GO Terms for genes affiliated with Neutropenia

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16Gene Ontology
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Cellular components related to Neutropenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.8THPO, KITLG, IL3, CSF1, CSF3, CSF2

Biological processes related to Neutropenia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.1C5AR1, FCGR3A, IL3, WAS, CSF3, CSF2
2positive regulation of cell proliferationGO:00828411.0CSF2, CSF3, CSF1, IL3, LEF1, BIRC5
3positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.9CSF3, HAX1, IL3, KITLG
4cellular response to cytokine stimulusGO:07134510.9LEF1, HAX1, CSF3
5positive regulation of DNA replicationGO:04574010.8KITLG, IL3, CSF2
6cellular response to lipopolysaccharideGO:07122210.7CSF2, CSF3, GFI1
7positive regulation of granulocyte differentiationGO:03085410.7LEF1, HAX1
8positive regulation of actin cytoskeleton reorganizationGO:200025110.6HAX1, CSF3
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.6IL3, CSF2
10positive regulation of macrophage derived foam cell differentiationGO:01074410.5CSF1, CSF2
11positive regulation of Ras protein signal transductionGO:04657910.3KITLG, CSF1

Molecular functions related to Neutropenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.7THPO, KITLG, IL3, CSF1, CSF3, CSF2
2N-formyl peptide receptor activityGO:00498210.6C5AR1, FPR1
3cytokine activityGO:00512510.5CSF2, CSF3, CSF1, IL3, KITLG, THPO

Products for genes affiliated with Neutropenia

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  • Antibodies
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Sources for Neutropenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet