MCID: NTR004
MIFTS: 58

Neutropenia

Categories: Blood diseases, Genetic diseases, Rare diseases, Bone diseases, Immune diseases, Nephrological diseases

Aliases & Classifications for Neutropenia

Summaries for Neutropenia

CDC : 3 People receiving chemotherapy are at risk for developing an infection when their white blood cell count is low. White blood cells are the body’s main defense against infection. This condition, called neutropenia, is common after receiving chemotherapy. For patients with this condition, any infection can become serious quickly.

MalaCards based summary : Neutropenia, also known as leukopenia, is related to neutropenia, severe congenital 1, autosomal dominant and neutropenia, severe congenital 3, autosomal recessive. An important gene associated with Neutropenia is VPS13B (Vacuolar Protein Sorting 13 Homolog B), and among its related pathways/superpathways are Immune response Role of DAP12 receptors in NK cells and Jak-STAT signaling pathway (KEGG). The drugs Lenograstim and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include breast, myeloid and lung, and related phenotypes are hematopoietic system and immune system

Wikipedia : 72 Neutropenia or neutropaenia, is an abnormally low concentration of neutrophils (a type of white blood... more...

Related Diseases for Neutropenia

Diseases in the Neutropenia family:

Neutropenia, Severe Congenital, 7, Autosomal Recessive Neutropenia, Severe Congenital 2, Autosomal Dominant
Neutropenia, Severe Congenital, 5, Autosomal Recessive Neutropenia, Severe Congenital 3, Autosomal Recessive
Neutropenia, Severe Congenital, 6, Autosomal Recessive Neutropenia, Severe Congenital 4, Autosomal Recessive
Neutropenia, Severe Congenital 1, Autosomal Dominant Severe Congenital Neutropenia
Elane-Related Neutropenia Neutropenia Chronic Familial
Severe Congenital Neutropenia Autosomal Dominant Gata1-Related Neutropenia

Diseases related to Neutropenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 327)
id Related Disease Score Top Affiliating Genes
1 neutropenia, severe congenital 1, autosomal dominant 33.4 CSF2 CSF3 ELANE IL3
2 neutropenia, severe congenital 3, autosomal recessive 33.1 CSF2 CSF3 CSF3R ELANE HAX1 IL3
3 hemolytic anemia 29.1 CSF2 CSF3 IL3 TOP1
4 poikiloderma with neutropenia 12.3
5 severe congenital neutropenia 12.3
6 neutropenia, cyclic 12.2
7 idiopathic neutropenia 12.2
8 3-methylglutaconic aciduria, type vii, with cataracts, neurologic involvement and neutropenia 12.1
9 neutropenia, severe congenital, x-linked 12.1
10 neutropenia, severe congenital, 5, autosomal recessive 12.1
11 neutropenia, nonimmune chronic idiopathic, of adults 12.1
12 neutropenia, severe congenital, 7, autosomal recessive 12.1
13 neutropenia, severe congenital 4, autosomal recessive 12.0
14 anemia, x-linked, with/without neutropenia and/or platelet abnormalities 12.0
15 neutropenia, severe congenital 2, autosomal dominant 12.0
16 neutropenia, severe congenital, 6, autosomal recessive 12.0
17 transient neonatal neutropenia 11.9
18 neutropenia, alloimmune neonatal 11.9
19 elane-related neutropenia 11.9
20 barth syndrome 11.8
21 severe congenital neutropenia autosomal dominant 11.8
22 neutropenia chronic familial 11.7
23 neutropenia lethal congenital with eosinophilia 11.7
24 neutropenia monocytopenia deafness 11.7
25 felty syndrome 11.7
26 autosomal recessive severe congenital neutropenia due to cxcr2 deficiency 11.6
27 gata1-related neutropenia 11.6
28 onychotrichodysplasia and neutropenia 11.6
29 hermansky-pudlak syndrome 2 11.4
30 clpb deficiency 11.3
31 whim syndrome 11.3
32 glycogen storage disease ib 11.1
33 large granular lymphocyte leukemia 11.0
34 cohen syndrome 11.0
35 wiskott-aldrich syndrome 11.0
36 2p16.1-p15 deletion syndrome 10.9 CSF3 ELANE
37 shaver's disease 10.9 ELANE GFI1
38 immunodeficiency 50 10.8
39 leukemia, acute lymphoblastic 10.8
40 ablepharon-macrostomia syndrome 10.7
41 lichtenstein syndrome 10.7
42 brachydactyly-distal symphalangism syndrome 10.7 CSF2 CSF3R
43 reticular dysgenesis 10.6
44 dentin dysplasia, type i, with microdontia and misshapen teeth 10.6
45 immunodeficiency due to purine nucleoside phosphorylase deficiency 10.6
46 immunodeficiency, x-linked, with hyper-igm 10.6
47 stenotrophomonas maltophilia infection 10.6
48 autoimmune lymphoproliferative syndrome, type ii 10.6
49 hermansky-pudlak syndrome 10 10.6
50 pearson marrow-pancreas syndrome 10.6

Comorbidity relations with Neutropenia via Phenotypic Disease Network (PDN): (show all 50)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Leukemia Agammaglobulinemia, X-Linked 1
Aplastic Anemia Autoimmune Hemolytic Anemia
Bronchitis Chronic Kidney Failure
Colorectal Cancer Decubitus Ulcer
Deficiency Anemia Esophageal Cancer
Esophageal Candidiasis Esophagitis
Felty Syndrome Female Breast Cancer
Heart Disease Hepatic Encephalopathy
Hydronephrosis Hypersplenism
Hypothyroidism Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1
Intestinal Obstruction Iron Deficiency Anemia
Leukemia, B-Cell, Chronic Lymphoblastic Leukemia
Main Bronchus Cancer Megakaryocytic Leukemia
Oral Candidiasis Ovarian Cancer, Somatic
Paralytic Ileus Plasma Cell Neoplasm
Pneumocystosis Portal Hypertension
Postinflammatory Pulmonary Fibrosis Primary Immunodeficiency Disease
Primary Thrombocytopenia Protein-Energy Malnutrition
Rectal Neoplasm Respiratory Failure
Retinitis Pigmentosa and Erythrocytic Microcytosis Rheumatoid Arthritis
Sideroblastic Anemia Stomach Cancer
Systemic Lupus Erythematosus Urinary Bladder Cancer
Waldenstrom Macroglobulinemia Wegener Granulomatosis

Graphical network of the top 20 diseases related to Neutropenia:



Diseases related to Neutropenia

Symptoms & Phenotypes for Neutropenia

MGI Mouse Phenotypes related to Neutropenia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 WAS CSF2 CSF3 CSF3R ELANE FCGR3B
2 immune system MP:0005387 9.36 CSF2 CSF3 CSF3R ELANE FCGR3B G6PC3

Drugs & Therapeutics for Neutropenia

Drugs for Neutropenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 493)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1 135968-09-1
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 124-94-7 31307
3
Ceftazidime Approved Phase 4,Phase 3,Phase 2 78439-06-2, 72558-82-8 5481173
4
Meropenem Approved, Investigational Phase 4,Phase 2 119478-56-7 64778 441130
5
Piperacillin Approved Phase 4,Phase 2 66258-76-2 43672
6
Tazobactam Approved Phase 4,Phase 2 89786-04-9 123630
7
Vancomycin Approved Phase 4,Phase 3,Phase 2 1404-90-6 441141 14969
8
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 3081921 477468
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
10
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
11
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
12
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
13
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137234-62-9 71616
14
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
15
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
16
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
17
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
18
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 23214-92-8 31703
19
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
20
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
21
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
22
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
23
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
24
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
25
Epirubicin Approved Phase 4,Phase 2,Phase 3,Phase 1 56420-45-2 41867
26
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
27
Methotrexate Approved Phase 4,Phase 2,Phase 3 1959-05-2, 59-05-2 126941
28
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
29
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 1 154361-50-9 60953
30
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
31
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
32
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2 84625-61-6 55283
33
Teicoplanin Approved Phase 4 61036-62-2
34
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
35
Tobramycin Approved, Investigational Phase 4,Phase 3 32986-56-4 5496 36294
36
Menthol Approved Phase 4 2216-51-5 16666
37
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 171228-49-2 147912
38
Diphenhydramine Approved Phase 4,Phase 3,Phase 1 58-73-1, 147-24-0 3100
39
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
40
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
41
Histamine Approved, Investigational Phase 4,Phase 1 75614-87-8, 51-45-6 774
42
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
43
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
44
Ondansetron Approved Phase 4,Phase 3,Phase 1 99614-02-5 4595
45
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
46
Promethazine Approved Phase 4,Phase 3,Phase 1 60-87-7 4927
47
Ranitidine Approved Phase 4 66357-59-3, 66357-35-5 3001055
48
Caspofungin Approved Phase 4,Phase 3,Phase 2,Phase 1 179463-17-3, 162808-62-0 468682 2826718
49
Fludarabine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 21679-14-1, 75607-67-9 30751
50
Zinc Approved Phase 4,Phase 3 7440-66-6 32051 23994

Interventional clinical trials:

(show top 50) (show all 685)

id Name Status NCT ID Phase Drugs
1 Prevention of Neutropenia After Using G-CSF With TAC Chemotherapy Unknown status NCT01571518 Phase 4 late leukostim;early leukostim
2 Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer Unknown status NCT00030758 Phase 4
3 Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia Unknown status NCT02463747 Phase 4 Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
4 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4 Micafungin
5 Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda Unknown status NCT00674921 Phase 4 cotrimoxazole;Placebo
6 Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia Completed NCT01581333 Phase 4
7 Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia Completed NCT02213783 Phase 4 Imipenem;Imipenem
8 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen Completed NCT01107756 Phase 4 LENOGRASTIM (GRANOGYTE 34)
9 Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer Completed NCT01649635 Phase 4 CABAZITAXEL (XRP6258);Prednisone;Ciprofloxacin;G-CSF (Granulocyte colony-stimulating factor)
10 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy to Prevent Neutropenia Completed NCT02805205 Phase 4 PEG-rhG-CSF
11 A Study of Empirical Antifungal Therapy With Itraconazole Completed NCT01706562 Phase 4 Itraconazole
12 Neulasta® in Subjects With Advanced Non-Small-Cell Lung Cancer (NSCLC) During Chemotherapy Completed NCT00115206 Phase 4 Neulasta® (pegfilgrastim)
13 A Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis After Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer Completed NCT00277160 Phase 4 Neulasta (pegfilgrastim)
14 FIRST - Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy Completed NCT00125723 Phase 4
15 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy Completed NCT02805153 Phase 4 PEG-rhG-CSF;rhG-CSF
16 Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients Completed NCT01401010 Phase 4 Doripenem;doripenem
17 The Relationship of Defeverscence and Itraconazole Plasma Level Study in Immunocompromised Participants Completed NCT01021683 Phase 4 Itraconazole
18 Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients Completed NCT00454272 Phase 4 Teicoplanin;Vancomycin
19 Observational Study Investigating the Response Rate of Itraconazole Injection in Treating Immunocompromised Patients Completed NCT01060462 Phase 4 Pts. w/ neutropenic fever associated w/ hematologic malignancy
20 The Tobramycin Study Completed NCT00257790 Phase 4 Tobramycin once a day
21 Antifungal Use in Oncohematological Neutropenic Patients Completed NCT00386802 Phase 4 Antifungal drug. VORICONAZOL. (VFEND®)
22 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
23 Safety of Cotrimoxazole in HIV- and HAART-exposed Infants Completed NCT01086878 Phase 4 cotrimoxazole
24 An Expanded Access Program of Pegfilgrastim (Neulastim) in Participants With Non-Hodgkin's Lymphoma (NHL) Completed NCT02782845 Phase 4 Chemotherapy;Immunochemotherapy;Pegfilgrastim
25 Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients Completed NCT01114165 Phase 4
26 Safety Study of Adjuvant Docetaxel-Carboplatin Treatment for Resected Lung Cancer Completed NCT00883675 Phase 4 Docetaxel-Carboplatin
27 Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115) Completed NCT00686543 Phase 4 Posaconazole
28 Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer Completed NCT02441894 Phase 4 CABAZITAXEL XRP6258;PEG-G-CSF;Prednisolone;Dexchlorpheniramine or Diphenhydramine;Ranitidine;Metoclopramide, Granisetron, or Ondansetron;Dexamethasone
29 Acetato de Caspofungin (Cancidas®) in the Treatment of Fungal Infection Completed NCT00388167 Phase 4 Caspofungin
30 PEG-rhG-CSF in Patients With Lymphoma Receiving Chemotherapy Completed NCT02805218 Phase 4 PEG-rhG-CSF
31 PEG-rhG-CSF in Patients With Malignant Solid Tumors Receiving Chemotherapy Completed NCT02805166 Phase 4 PEG-rhG-CSF
32 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
33 Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma Completed NCT00969462 Phase 4 Doxorubicin
34 Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection Completed NCT01198236 Phase 4 Itraconazole
35 Antifugal Effect of Recombinant Human Granulocyte-macrophage Stimulating Factor (rhGM-CSF) in Patients Post Allo-HSCT Completed NCT01232504 Phase 4 rhGM-CSF group;rhG-CSF+rhGM-CSF group;rhG-CSF group
36 SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia Completed NCT00487448 Phase 4 Fludarabine;Cytarabine;G-CSF;Idarubicin
37 Oral Zinc Therapy for the Prevention of Mucositis Completed NCT00449592 Phase 4 Zinc;Placebo
38 Phase II Trial Evaluating Irinotecan and Capecitabine Relapsed/Refractory Upper GI Tumours Completed NCT00220168 Phase 4 Irinotecan, Capecitabine
39 Prospective, Open-label Tolerability and Safety Monitoring Study of Novantrone in a Selected Cohort of Multiple Sclerosis Patients Completed NCT00262314 Phase 4
40 A Study of The Relationship Between Drop in Hemoglobin and Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Copegus (Ribavirin) and Pegasys (Peginterferon Alfa-2a) Completed NCT01585324 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin [Copegus]
41 Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3 Completed NCT00056862 Phase 4 Peginterferon alfa-2a;Peginterferon alfa-2a;Ribavirin
42 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
43 Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO Recruiting NCT02149329 Phase 4 Discontinuation of imipenem-cilastatin or meropenem
44 PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia Recruiting NCT02996617 Phase 4 rhG-CSF regimen;Pegylated rhG-CSF regimen
45 Granulocyte-colony Stimulating Factors or Antibiotics for Primary Prophylaxis for Febrile Neutropenia Recruiting NCT02816112 Phase 4 Ciprofloxacin;Neupogen
46 A Study to Compare Administration Schedules of G-CSF (Filgrastim) for Primary Prophylaxis of Febrile Neutropenia Recruiting NCT02816164 Phase 4 Neupogen
47 The Efficacy and Safety of PEG-rhG-CSF in Neutropenia After Chemotherapy Recruiting NCT02905916 Phase 4 PEG-rhG-CSF
48 Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg Recruiting NCT02621905 Phase 4 Sporanox;Lozanoc
49 Blood Draw Validation for Ciprofloxacin Pharmacokinetic Research in Pediatric Cancer Patients Recruiting NCT02967341 Phase 4
50 Epirubicin Versus Docetaxel Plus Cyclophosphamide in Lymph Node Negative, ER-positive, Her2-negative Breast Cancer Recruiting NCT02549677 Phase 4 Epirubicin;Docetaxel;cyclophosphamide

Search NIH Clinical Center for Neutropenia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Neutropenia cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: neutropenia

Genetic Tests for Neutropenia

Genetic tests related to Neutropenia:

id Genetic test Affiliating Genes
1 Neutropenia 29

Anatomical Context for Neutropenia

MalaCards organs/tissues related to Neutropenia:

39
Breast, Myeloid, Lung, Neutrophil, Bone, Bone Marrow, T Cells

Publications for Neutropenia

Articles related to Neutropenia:

(show top 50) (show all 1589)
id Title Authors Year
1
Immunoglobulin and B-cell disturbances in patients with chronic idiopathic neutropenia. ( 28732781 )
2017
2
Soluble CD14 as a Diagnostic and Prognostic Biomarker in Hematological Patients with Febrile Neutropenia. ( 28845081 )
2017
3
Severe Neutropenia After Leukocytosis During an Acute Attack of Mycoplasma Infection-associated Paroxysmal Cold Hemoglobinuria. ( 28234745 )
2017
4
UGT1A1*6 polymorphisms are correlated with irinotecan-induced neutropenia: a systematic review and meta-analysis. ( 28585035 )
2017
5
Sodium valproate and clozapine induced neutropenia: A case control study using register data. ( 28882687 )
2017
6
Prognostic importance of temozolomide-induced neutropenia in glioblastoma, IDH-wildtype patients. ( 28887717 )
2017
7
Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia. ( 28938529 )
2017
8
Granulocyte colony-stimulating factor receptor signaling in severe congenital neutropenia, chronic neutrophilic leukemia, and related malignancies. ( 27789332 )
2017
9
Neutropenia in Patients with Common Variable Immunodeficiency: a Rare Event Associated with Severe Outcome. ( 28842786 )
2017
10
Granulocyte colony-stimulating factors in the prevention of febrile neutropenia: review of cost-effectiveness models. ( 28064553 )
2017
11
A novel homozygous VPS45 p.P468L mutation leading to severe congenital neutropenia with myelofibrosis. ( 28453180 )
2017
12
Diagnostic value of sTREM-1, IL-8, PCT, and CRP in febrile neutropenia after autologous stem cell transplantation. ( 28920169 )
2017
13
Extended infusion compared to standard infusion cefepime as empiric treatment of febrile neutropenia. ( 28077047 )
2017
14
Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia. ( 27975098 )
2017
15
Predictive performance of the quick Sequential Organ Failure Assessment score as a screening tool for sepsis, mortality, and intensive care unit admission in patients with febrile neutropenia. ( 28062972 )
2017
16
Suspected immune-mediated neutropenia and corticosteroid responsive pancytopenia in a Portuguese water dog. ( 28042161 )
2017
17
Idiosyncratic drug-induced neutropenia & agranulocytosis. ( 28069912 )
2017
18
A Truncated G-CSFR Inhibits Apoptosis Induced by Neutrophil Elastase G185R Mutant: Implication for Understanding CSF3R Mutations in Severe Congenital Neutropenia. ( 28073911 )
2017
19
Risk of Febrile Neutropenia Associated With Select Myelosuppressive Chemotherapy Regimens in a Large Community-Based Oncology Practice. ( 28874597 )
2017
20
Antimicrobial stewardship in paediatric oncology: Impact on optimising gentamicin use in febrile neutropenia. ( 28901726 )
2017
21
Impaired lung repair during neutropenia can be reverted by matrix metalloproteinase-9. ( 28947666 )
2017
22
An update on the diagnosis and treatment of chronic idiopathic neutropenia. ( 27841775 )
2017
23
A GCSFR/CSF3R zebrafish mutant models the persistent basal neutrophil deficiency of severe congenital neutropenia. ( 28281657 )
2017
24
Treatment with granulocyte colony-stimulating factor in the refeeding phase of anorexia nervosa complicated with severe neutropenia and sepsis: a case report. ( 28871553 )
2017
25
Cytotoxic T cells in chronic idiopathic neutropenia express restricted antigen receptors. ( 28535087 )
2017
26
External Validation of Six Pediatric Fever and Neutropenia Clinical Decision Rules. ( 28877157 )
2017
27
UGT1A1 Gene Polymorphism Predicts Irinotecan-Induced Severe Neutropenia and Diarrhea in Chinese Cancer Patients. ( 28879724 )
2017
28
Congenital neutropenia in the era of genomics: classification, diagnosis, and natural history. ( 28875503 )
2017
29
Sepsis and persisting neutropenia in a drug addict. ( 28052478 )
2017
30
Association of time to antibiotics and clinical outcomes in adult hematologic malignancy patients with febrile neutropenia. ( 28077045 )
2017
31
Chemotherapy-induced neutropenia and the prognosis of colorectal cancer: a meta-analysis of cohort studies. ( 28910204 )
2017
32
Time trends in utilization of G-CSF prophylaxis and risk of febrile neutropenia in a Medicare population receiving adjuvant chemotherapy for early-stage breast cancer. ( 28921379 )
2017
33
APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia. ( 28882023 )
2017
34
Plasma presepsin level is an early diagnostic marker of severe febrile neutropenia in hematologic malignancy patients. ( 28056845 )
2017
35
Refining the role of pegfilgrastim (a long-acting G-CSF) for prevention of chemotherapy-induced febrile neutropenia: consensus guidance recommendations. ( 28842778 )
2017
36
Poikiloderma with Neutropenia in Morocco: a Report of Four Cases. ( 28353165 )
2017
37
Evaluation of serum galactomannan enzyme immunoassay at two different cut-offs for the diagnosis of invasive aspergillosis in patients with febrile neutropenia. ( 28681812 )
2017
38
Expanded access to cancer treatments from conversion to neutropenia prophylaxis with biosimilar filgrastim-sndz. ( 28870106 )
2017
39
Prospective cohort study of procalcitonin levels in children with cancer presenting with febrile neutropenia. ( 28056911 )
2017
40
Non-chemotherapy drug-induced neutropenia - an update. ( 28879784 )
2017
41
Meta-analysis on the Influence of Antifungal Spectrum on Effectiveness of Empirical Antifungal Therapy for Febrile Neutropenia. ( 28867698 )
2017
42
Neutropenia in the Febrile Child. ( 27139294 )
2016
43
Gangrenous appendicitis in a patient with severe congenital neutropenia. ( 27804250 )
2016
44
Use of biomarkers in the management of febrile neutropenia episodes in children with cancer. ( 27208564 )
2016
45
Procalcitonin-guided protocol is not useful to manage antibiotic therapy in febrile neutropenia: a randomized controlled trial. ( 27118539 )
2016
46
ANA-Negative Presentation of SLE in Man with Severe Autoimmune Neutropenia. ( 28077945 )
2016
47
Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction. ( 27128488 )
2016
48
Prospective cohort study of febrile neutropenia in breast cancer patients with neoadjuvant and adjuvant chemotherapy: CSPOR-BC FN study. ( 27162322 )
2016
49
Long-term use of Pegfilgrastim in children with severe congenital neutropenia: clinical and pharmacokinetic data. ( 27621310 )
2016
50
COST OF FEBRILE NEUTROPENIA TREATMENT IN BOSNIA AND HERZEGOVINA. ( 27147916 )
2016

Variations for Neutropenia

ClinVar genetic disease variations for Neutropenia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 VPS13B NM_017890.4(VPS13B): c.11314C> T (p.Gln3772Ter) single nucleotide variant Pathogenic/Likely pathogenic rs386834061 GRCh37 Chromosome 8, 100880540: 100880540
2 VPS13B NM_017890.4(VPS13B): c.4620delA (p.Ser1541Profs) deletion Pathogenic rs1057518939 GRCh37 Chromosome 8, 100523652: 100523652

Expression for Neutropenia

Search GEO for disease gene expression data for Neutropenia.

Pathways for Neutropenia

GO Terms for Neutropenia

Biological processes related to Neutropenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.58 CSF2 CSF3 GFI1
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.5 CSF3 HAX1 IL3
3 immune response GO:0006955 9.43 CSF2 CSF3 FCGR3A FCGR3B IL3 WAS
4 positive regulation of actin cytoskeleton reorganization GO:2000251 9.37 CSF3 HAX1
5 glucose-6-phosphate transport GO:0015760 9.16 G6PC3 SLC37A4
6 regulation of myeloid cell differentiation GO:0045637 8.96 CSF3R
7 neutrophil differentiation GO:0030223 8.62 CSF2 JAGN1

Molecular functions related to Neutropenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 8.62 FCGR3A FCGR3B

Sources for Neutropenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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