LWNH
MCID: NVD003
MIFTS: 17

Nevoid Hypermelanosis, Linear and Whorled (LWNH) malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Nevoid Hypermelanosis, Linear and Whorled

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Sources:
31ICD10 via Orphanet, 48NIH Rare Diseases, 52OMIM, 54Orphanet, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Nevoid Hypermelanosis, Linear and Whorled:

Name: Nevoid Hypermelanosis, Linear and Whorled 52 48
Linear and Whorled Nevoid Hypermelanosis 48 54 68
Reticulate Hyperpigmentation of Iijima 48
Linear and Whorled Hypermelanosis 48
 
Zosteriform Hyperpigmentation 48
Zosteriform Lentiginous Nevus 48
Zebra-Like Hyperpigmentation 48
Lwnh 48

Characteristics:

HPO:

64
nevoid hypermelanosis, linear and whorled:
Inheritance: autosomal dominant inheritance, sporadic
Onset and clinical course: infantile onset

Classifications:

Orphanet: 54 
Rare skin diseases


External Ids:

OMIM52 614323
Orphanet54 ORPHA79150
ICD10 via Orphanet31 L81.4
UMLS via Orphanet69 C1304501

Summaries for Nevoid Hypermelanosis, Linear and Whorled

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NIH Rare Diseases:48 Linear and whorled nevoid hypermelanosis (lwnh) is a rare skin condition characterized by swirling streaks of hyperpigmented (darkened) skin. the pigmentation follows the lines of blashko and is mainly located on the trunk and limbs. it is present at birth or appears in the first few weeks of life. it typically progresses for one to two years and then stabilizes. hyperpigmentation is usually the only symptom but there are isolated reports of other symptoms, involving mostly the central nervous system, musculoskeletal system, and heart. while most cases of lwnh are sporadic, apparent genetic transmission rarely has been described. a few people with lwnh have been diagnosed with chromosomal mosaicism. last updated: 1/23/2017

MalaCards based summary: Nevoid Hypermelanosis, Linear and Whorled, also known as linear and whorled nevoid hypermelanosis, is related to ichthyosis vulgaris and ichthyosis, and has symptoms including eosinophilia and hyperpigmented streaks. Affiliated tissues include skin and heart.

OMIM:52 Linear and whorled hypermelanosis (LWNH) is a benign skin condition characterized by onset in infancy of hyperpigmented... (614323) more...

Wikipedia:71 Linear and whorled nevoid hypermelanosis (also known as \"Linear nevoid hyperpigmentation,\"... more...

Related Diseases for Nevoid Hypermelanosis, Linear and Whorled

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Diseases related to Nevoid Hypermelanosis, Linear and Whorled via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1ichthyosis vulgaris10.1
2ichthyosis10.1
3cerebritis10.1
4inflammatory linear verrucous epidermal nevus10.1
5aneurysm10.1
6cerebral aneurysms10.1

Graphical network of diseases related to Nevoid Hypermelanosis, Linear and Whorled:



Diseases related to nevoid hypermelanosis, linear and whorled

Symptoms & Phenotypes for Nevoid Hypermelanosis, Linear and Whorled

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Symptoms by clinical synopsis from OMIM:

614323

Clinical features from OMIM:

614323

Human phenotypes related to Nevoid Hypermelanosis, Linear and Whorled:

 64
id Description HPO Frequency HPO Source Accession
1 eosinophilia64 HP:0001880
2 hyperpigmented streaks64 HP:0007572

Drugs & Therapeutics for Nevoid Hypermelanosis, Linear and Whorled

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Nevoid Hypermelanosis, Linear and Whorled

Genetic Tests for Nevoid Hypermelanosis, Linear and Whorled

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Anatomical Context for Nevoid Hypermelanosis, Linear and Whorled

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MalaCards organs/tissues related to Nevoid Hypermelanosis, Linear and Whorled:

36
Skin, Heart

Publications for Nevoid Hypermelanosis, Linear and Whorled

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Variations for Nevoid Hypermelanosis, Linear and Whorled

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Expression for genes affiliated with Nevoid Hypermelanosis, Linear and Whorled

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Search GEO for disease gene expression data for Nevoid Hypermelanosis, Linear and Whorled.

Pathways for genes affiliated with Nevoid Hypermelanosis, Linear and Whorled

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GO Terms for genes affiliated with Nevoid Hypermelanosis, Linear and Whorled

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Sources for Nevoid Hypermelanosis, Linear and Whorled

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet