Nevus malady

Wikipedia: Nevus (or naevus, plural nevi or naevi, from nævus, Latin for \"birthmark\") is the medical term for...⁴⁴ more...

MalaCards: Nevus, also known as benign melanocytic nevus, is related to spitz nevus and blue rubber bleb nevus syndrome. An important gene associated with Nevus is CMM (cutaneous malignant melanoma/dysplastic nevus), and among its related pathways are Pancreatic cancer and Signal transduction_PTEN pathway. The compounds threonine and vincristine have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and tongue, and related mouse phenotypes are endocrine/exocrine gland and craniofacial.

nevus 7 benign melanocytic nevus 43

Diseases related to nevus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 744)

id	Related Disease	Score	Top Affiliating Genes
1	spitz nevus	33.1	PCNA, BRAF, HRAS, TP53, NRAS
2	blue rubber bleb nevus syndrome	32.8	MYB, CLEC2A, MXI1, S100B, MLANA, MITF
3	nevoid basal cell carcinoma syndrome	31.9	PCNA, MC1R, TP53, PTCH1, PTCH2, SMO
4	hereditary mucosal leukokeratosis	31.4	PCNA, MKI67, KRT1
5	epidermal nevus vitamin d resistant rickets	30.1	CD8A, FGF23, FGFR3, IKBKG, PTEN, CREBBP
6	melanoma metastasis	29.6	KIT, MYB, S100B, CDKN2A, CD34, ITGA6
7	rickets	28.5	FGF23, MEPE, CREBBP, PHEX, KRT10
8	carney complex	28.5	F13A1, PTEN, SYP, POMC
9	syringocystadenoma papilliferum	28.3	PCNA, VIM, SCAP, MUC1, S100B, PTCH1
10	familial melanoma	28.1	BRAF, CMM, CDKN2A, CDK4, MC1R
11	leopard syndrome	28.0	PIK3CA, BRAF, HRAS, NF1
12	hermansky-pudlak syndrome	27.9	HPS1, TYR, TYRP1, DCT, PMEL
13	epidermolytic hyperkeratosis	27.8	FLG, KRT5, KRT16, KRT1, KRT10
14	twinning	27.5	MUC1, XRCC3, XRCC5, CDKN2A, CDK4, FGFR3
15	epidermolysis bullosa simplex	26.8	VIM, FLG, KRT5, KRT16, KRT17, KRT1
16	cutaneous leiomyosarcoma	26.8	KIT, VIM, MUC1, S100B, ACTC1, DES
17	basal cell carcinoma	26.7	BCL2, XRCC3, CD34, MKI67, MC1R, F13A1
18	sweat gland carcinoma	26.6	PCNA, MUC1, S100A1, S100B, TP53, KRT13
19	alopecia	25.9	KIT, CLEC2A, MUC1, CDKN2A, CD34, FOXN1
20	epidermolysis bullosa	25.9	VIM, MUC1, CDKN2A, ITGA6, FLG, FGF2
21	leukoplakia	25.4	PCNA, BCL2, CDKN2A, MKI67, FLG, CCND1
22	paraganglioma	25.0	KIT, PCNA, VIM, BCL2, S100A1, S100B
23	hypercalcemia	24.3	VIM, BMP6, IRF4, FGF2, FGF23, FGFR3
24	medulloblastoma	24.2	PIK3CA, KIT, PCNA, VIM, MYB, BCL2
25	cutaneous malignant melanoma	24.1	KIT, PCNA, SELE, BRAF, CMM, BCL2
26	rhabdomyosarcoma	23.2	PCNA, VIM, BMP6, BCL2, S100A1, S100B
27	leiomyosarcoma	22.0	KIT, PCNA, VIM, BCL2, MUC1, S100A1
28	psoriasis	21.2	PCNA, SELE, VIM, BCL2, S100A1, S100B
29	cerebritis	20.8	KIAA1147, PCNA, SELE, VIM, BMP6, BCL2
30	melanoma	20.6	PIK3CA, KIT, PCNA, SELE, VIM, BRAF
31	inflammatory bowel disease	20.1	KIT, PCNA, SELE, BRAF, BMP6, BCL2
32	meningioma	19.1	PCNA, SELE, VIM, BCL2, MUC1, XRCC3
33	fibrosis	19.0	PIK3CA, KIT, PCNA, SELE, VIM, BMP6
34	sarcoma	17.3	PIK3CA, KIT, PCNA, SELE, VIM, BRAF
35	breast carcinoma	17.2	PIK3CA, KIT, PCNA, SELE, VIM, BRAF
36	carcinoma	16.6	PIK3CA, KIT, PCNA, SELE, VIM, BRAF
37	acanthoma	14.0	PCNA, CLEC2A, KRT16, KRT1, KRT10
38	epidermolytic acanthoma	14.0	KRT16, KRT1, KRT10
39	superficial spreading melanoma	14.0	S100B, CDKN2A, CDK4, MLANA, MITF, CCND1
40	mesenchymal cell neoplasm	14.0	PCNA, CCND1, HRAS, SYP
41	kidney clear cell sarcoma	14.0	KIT, BRAF, S100B, MITF
42	lentigo maligna melanoma	14.0	S100B, MLANA, MITF
43	amelanotic melanoma	14.0	S100B, TYR, TYRP1, DCT
44	pigmentation disease	13.9	KIT, MITF, TYR
45	retroperitoneal sarcoma	13.9	CDK4, MLANA, CREBBP, TYR
46	oligodendroglioma	13.9	BRAF, CDKN2A, PTEN, EGFR
47	plasma cell leukemia	13.9	BRAF, CDKN2A, CDK4, IRF4, FGFR3, CCND1
48	penile cancer	13.9	PIK3CA, CDKN2A, HRAS
49	steatocystoma multiplex	13.9	KRT16, KRT17, KRT10
50	ocular albinism	13.9	MLANA, MITF, HPS1, TYR, TYRP1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to nevus:

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MGI Mouse Phenotypes related to nevus:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.1	MXI1, FOXN1, MITF, GNAQ, CRHR1, NF1
2	craniofacial phenotype	MP:0005382	9.8	KIT, FLG, MITF, MC1R, GNAQ, HPS1
3	respiratory system phenotype	MP:0005388	9.7	FGF23, MB, GNAQ, F13A1, HPS1, SMO
4	normal phenotype	MP:0002873	9.5	SYP, TYR, NF1, CRHR1, CREBBP, SMO
5	liver/biliary system phenotype	MP:0005370	9.3	STARD4, KIT, EGFR, NF1, PLIN1, TP53
6	limbs/digits/tail phenotype	MP:0005371	9.2	KIT, ROR2, EGFR, CREBBP, PHEX, NF1
7	renal/urinary system phenotype	MP:0005367	8.6	TYR, FAIM2, APC, FGFR3, FGF23, ITGA6
8	pigmentation phenotype	MP:0001186	8.5	IKBKG, GNAQ, HPS1, TP53, PTCH1, PTEN
9	hearing/vestibular/ear phenotype	MP:0005377	8.3	SMO, HPS1, GNAQ, PHEX, NF1, KRT10
10	reproductive system phenotype	MP:0005389	8.3	FGF23, FGFR3, APC, CCND1, IKBKG, HRAS
11	no phenotypic analysis	MP:0003012	8.1	SYP, HOPX, EGFR, TP53, SST, KRT19
12	nervous system phenotype	MP:0003631	8.0	FGF2, ITGA6, CDK4, CD8A, XRCC5, BRAF
13	adipose tissue phenotype	MP:0005375	8.0	ROR2, PTHLH, BCL2, PIK3CA, PTEN, TP53
14	embryogenesis phenotype	MP:0005380	8.0	CREBBP, NF1, NRAS, KRT19, EGFR, TYR
15	hematopoietic system phenotype	MP:0005397	7.6	XRCC5, CD8A, CD34, MXI1, BCL2, BRAF
16	skeleton phenotype	MP:0005390	7.6	FGF2, HRAS, TP53, PTCH1, PTEN, PTHLH
17	immune system phenotype	MP:0005387	7.5	KIT, VIM, BRAF, MYB, HPS1, TP53
18	muscle phenotype	MP:0005369	7.5	BCL2, BRAF, VIM, KIT, PIK3CA, PTEN
19	behavior/neurological phenotype	MP:0005386	6.9	S100A1, STARD4, BRAF, VIM, SELE, KIT
20	tumorigenesis	MP:0002006	6.7	CDKN2A, CD34, CDK4, CDH1, ITGA6, FOXN1
21	digestive/alimentary phenotype	MP:0005381	6.2	KRT4, PHEX, CREBBP, SMO, NRAS, SST
22	vision/eye phenotype	MP:0005391	6.1	PLIN2, NF1, KRT4, KRT14, EGF, EGFR
23	mortality/aging	MP:0010768	6.0	KRT16, KRT17, KRT1, KRT10, KRT19, KRT14
24	cardiovascular system phenotype	MP:0005385	5.0	BRAF, VIM, SELE, KIT, PIK3CA, MYB
25	integument phenotype	MP:0010771	4.9	CDKN2A, CD34, CDK4, CDH1, ITGA6, FOXN1
26	cellular phenotype	MP:0005384	4.7	KIT, FGF2, FGFR3, APC, MC1R, MB
27	growth/size phenotype	MP:0005378	3.9	KRT4, KRT16, KRT10, KRT19, EGF, EGFR
28	homeostasis/metabolism phenotype	MP:0005376	3.9	PTEN, KRT16, SST, PHEX, PTHLH, PLIN1

Articles related to nevus:

(show top 50)    (show all 107)

id	Title	Authors	Year	Affiliating Genes
1	IRF4 variants have age-specific effects on nevus coun t and predispose to melanoma. (20602913)	Duffy D.L.... Montgomery G.W.	2010	IRF4
2	Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom. (20647408)	Newton-Bishop J.A.... Bishop D.T.	2010	PLA2G6, MTAP, IRF4
3	Germline PTCH1 mutations in Japanese basal cell nevus syndrome patients. (19557015)	Takahashi C.... Nakano Y.	2009	PTCH1
4	Distinguishing epithelioid blue nevus from blue nevus -like cutaneous melanoma metastasis using fluorescence in situ hybridization. (19606012)	Pouryazdanparast P.... Gerami P.	2009	CCND1, MYB
5	Epidermolysis bullosa nevus arising in a patient with Dowling-Meara type epidermolysis bullosa simplex with a novel K5 mutation. (19691749)	Sugiyama-Fukamatsu H.... Iwatsuki K.	2009	KRT5
6	Melanocytic nevus-like hyperplasia and melanoma in tr ansgenic BRAFV600E mice. (19398955)	Goel V.K.... Haluska F.G.	2009	BRAF
7	Matrix extracellular phosphoglycoprotein (MEPE) correlates with serum phosphorus prior to and during octreotide treatment and following excisional surgery in hypophosphatemic linear sebaceous nevus syndrome. (18627046)	Hoffman W.H.... Fedarko N.S.	2008	MEPE
8	E-cadherin expression in the subepithelial nevus cells of the giant congenital nevocellular nevi (GCNN) correlates with their migration ability in vitro. (18502615)	Matsuda N.... Kishi K.	2008	CDH1
9	Linear Cowden nevus: a new distinct epidermal nevus. (17337396)	Happle R.	2007	PTEN
10	Identification of a Keratin 4 mutation in a chemically induced mouse mutant that models white sponge nevus. (16858417)	McGowan K.A.... Barsh G.S.	2007	KRT4
11	A germline PTEN mutation with manifestations of prenatal onset and verrucous epidermal nevus. (16752378)	Tekin M.... Akar N.	2006	PTEN
12	Patched homologue 1 mutations in four Japanese families with basal cell nevus syndrome. (17021131)	Matsuzawa N.... Yoshiura K.I.	2006	PTCH1
13	Identification of genetic loci for basal cell nevus syndrome and inflammatory bowel disease in a single large pedigree. (16733713)	Panhuysen C.I.... Brant S.R.	2006	PTCH1
14	Review of patients with basal cell nevus syndrome. (16855496)	Taylor S.F.... Leatherbarrow B.	2006	PTCH1
15	Hypophosphatemic rickets associated with epidermal nevus syndrome and giant hairy nevus. (15679074)	Chou Y.Y.... Lin S.J.	2005	PHEX
16	Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma. (16096402)	van Dijk M.C.... Ruiter D.J.	2005	HRAS, BRAF
17	Elevated fibroblast growth factor-23 in hypophosphatemic linear nevus sebaceous syndrome. (15742370)	Hoffman W.H.... Given K.S.	2005	FGF23
18	Nevus distribution in a Utah melanoma kindred with a temperature-sensitive CDKN2A mutation. (16354203)	Florell S.R.... Leachman S.A.	2005	CDKN2A
19	Genetic similarities between Spitz nevus and Spitzoid melanoma in children. (15503312)	Gill M.... Celebi J.T.	2004	HRAS, BRAF
20	Longitudinal assessment of the nevus phenotype in a melanoma kindred. (15304099)	Florell S.R.... Leachman S.A.	2004	CDKN2A
21	Rosette formation within a proliferative nodule of an atypical combined melanocytic nevus in an adult. (12544098)	Hoang M.P.... Amirkhan R.H.	2003	MLANA
22	Intraparenchymal nevus cell aggregates in lymph nodes: a possible diagnostic pitfall with malignant melanoma and carcinoma. (12717252)	Biddle D.A.... Prieto V.G.	2003	S100B, PMEL
23	Linkage and association analysis of nevus density and the region containing the melanoma gene CDKN2A in UK twins. (12799637)	Barrett J.H.... Bishop D.T.	2003	CDKN2A
24	An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility allele. (12406345)	Bertram C.G.... Newton Bishop J.A.	2002	CDKN2A
25	Congenital giant melanocytic nevus with pigmented epithelioid cells: a variant of epithelioid blue nevus. (11803278)	MartA-nez-Barba E.... Requena L.	2002	S100B, MITF, MLANA
26	Chronic subcutaneous octreotide decreases gastrointestinal blood loss in blue rubber-bleb nevus syndrome. (11568521)	Gonzalez D.... Andersen J.M.	2001	SST
27	Heritability and gene-environment interactions for melanocytic nevus density examined in a U.K. adolescent twin study. (11511314)	Wachsmuth R.C.... Newton Bishop J.A.	2001	CDK4
28	Recurrent melanocytic nevus: a histologic and immunohistochemical evaluation. (11493377)	Hoang M.P.... Shea C.R.	2001	S100B, TYR, MLANA
29	Analysis of the p16 gene status of non-familial dysplastic nevus syndrome patients. (11820732)	Matsumura Y.... Miyachi Y.	2001	CDKN2A
30	Keratotic melanocytic nevus: a clinicopathologic and immunohistochemical study. (10917161)	Horenstein M.G.... Shea C.R.	2000	EGFR
31	A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus. (10844556)	Terrinoni A.... Melino G.	2000	KRT16
32	Cerebriform intradermal nevus: a case of scalp expansion on the galea. (10343474)	Hashimoto I.... Arase S.	1999	PCNA
33	Adnexal-centered giant congenital melanocyte nevus with extensive ganglioneuromatous component and trisomy 7. (10441625)	Drut R.... Cohen M.	1999	S100B, SYP
34	Benign nevus cell aggregates in the thymus: a case re port. (10102620)	Parker J.R.... OrdA^A+ez N.G.	1999	MKI67
35	FGF expression allows nevus cells to survive in three-dimensional collagen gel under conditions that induce apoptosis in normal human melanocytes. (10417628)	Alanko T.... Saksela O.	1999	FGF2
36	Growth stimulation of normal melanocytes and nevocellular nevus cells by gastrin releasing peptide (GRP). (9673890)	Terashi H.... Takayasu S.	1998	GRP
37	Nevus cell aggregates in axillary lymph nodes in sim ultaneous mucinous breast carcinoma (9746916)	Droste A.... Bachler B.	1998	S100B
38	Allelic deletion at chromosome 9p21(p16) and 17p13(p53) in microdissected sporadic dysplastic nevus. (9490270)	Park W.S.... Zhuang Z.	1998	CDKN2A
39	Genetic alterations of p16INK4a and p53 genes in sporadic dysplastic nevus. (9299424)	Lee J.Y.... Yoo N.J.	1997	CDKN2A
40	Nevus spilus (speckled lentiginous nevus) associated with a nodular neurotized nevus. (9185922)	Hwang S.M.... Ahn S.K.	1997	S100B, MBP
41	Interferon alpha-2a therapy for disseminated intravascular coagulation in a patient with blue rubber bleb nevus syndrome. A case report. (9071205)	Kunishige M.... Saito S.	1997	IFNA2
42	Adhesive and migratory behaviors of nevus cells differ from those of epidermal melanocytes and are not linked to the histological type of nevus. (8752661)	Mengeaud V.... Verrando P.	1996	ITGA6
43	A mutation in the mucosal keratin K4 is associated with oral white sponge nevus. (7493030)	Rugg E.L.... Munro C.S.	1995	KRT4
44	Expression of proliferating cell nuclear antigen in Spitz nevus. (7751466)	Penneys N.... Vogler C.	1995	PCNA
45	Immunohistochemical study of p53 protein expression i n Spitz nevus as compared with other melanocytic lesions. (8599466)	Bergman R.... Lichtig C.	1995	TP53
46	PCNA expression and nucleolar organizer regions in malignant melanoma and nevus cell nevus. (7739200)	Kanoko M.... Ichihashi M.	1994	PCNA
47	A case of ductal sweat gland carcinoma connected to syringocystadenoma papilliferum arising in nevus sebaceus. (7699123)	Ansai S.... Kondo S.	1994	PCNA
48	Genetic and clinical mosaicism in a type of epidermal nevus. (7526210)	Paller A.S.... Fuchs E.	1994	KRT10
49	Growth regulation of cultured human nevus cells. (8440904)	Mancianti M.L.... Herlyn M.	1993	FGF2
50	Basal cell nevus syndrome and medulloblastoma: a case report. (8060441)	Romero PAcrez J.A.... Lleras Santana I.	1993	PTCH1

Genes related to nevus according to GeneCards:

(show top 50)    (show all 104)

id	Symbol	Description	Score	GeneCards Section Context
1	CMM	cutaneous malignant melanoma/dysplastic nevus	11.1	Aliases & Descriptions, Summaries
2	KRT16	keratin 16	11.1	Publications, Summaries
3	KRT13	keratin 13	11.1	Summaries, Publications
4	KRT4	keratin 4	11.1	Summaries, Publications
5	PTCH1	patched 1	11.1	Publications, Orthologs, Summaries
6	S100B	S100 calcium binding protein B	11.0	Publications
7	RREB1	ras responsive element binding protein 1	11.0
8	MLANA	melan-A	11.0	Publications
9	FGF23	fibroblast growth factor 23	11.0	Publications
10	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	11.0
11	FGFR3	fibroblast growth factor receptor 3	11.0	Publications
12	PCNA	proliferating cell nuclear antigen	11.0	Publications
13	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0	Publications
14	MUSTN1	musculoskeletal, embryonic nuclear protein 1	11.0
15	CD8A	CD8a molecule	11.0	Publications
16	KRT10	keratin 10	11.0	Publications
17	CWC22	CWC22 spliceosome-associated protein homolog (S. cerevisiae)	11.0
18	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
19	SYP	synaptophysin	11.0	Publications
20	MITF	microphthalmia-associated transcription factor	11.0	Publications
21	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0	Publications
22	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
23	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	11.0
24	CCND1	cyclin D1	11.0	Publications
25	FOXN1	forkhead box N1	11.0
26	CLEC2A	C-type lectin domain family 2, member A	11.0
27	HPS1	Hermansky-Pudlak syndrome 1	11.0	Publications
28	HOPX	HOP homeobox	11.0
29	PMEL	premelanosome protein	11.0	Publications
30	TYRP1	tyrosinase-related protein 1	11.0	Publications
31	KRT1	keratin 1	11.0	Publications
32	KRT15	keratin 15	11.0
33	NSDHL	NAD(P) dependent steroid dehydrogenase-like	11.0
34	FAIM2	Fas apoptotic inhibitory molecule 2	11.0
35	MXI1	MAX interactor 1	11.0	Publications
36	S100A1	S100 calcium binding protein A1	11.0	Publications
37	MYB	v-myb myeloblastosis viral oncogene homolog (avian)	11.0	Publications
38	DCT	dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)	11.0	Publications
39	PHEX	phosphate regulating endopeptidase homolog, X-linked	11.0	Publications
40	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	11.0
41	CSE1L	CSE1 chromosome segregation 1-like (yeast)	11.0
42	PRTN3	proteinase 3	11.0
43	PTEN	phosphatase and tensin homolog	11.0	Publications
44	CDK4	cyclin-dependent kinase 4	11.0	Publications
45	TYR	tyrosinase (oculocutaneous albinism IA)	11.0	Publications
46	SST	somatostatin	11.0	Publications
47	MBP	myelin basic protein	11.0	Publications
48	NF1	neurofibromin 1	11.0	Publications
49	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
50	IFNA2	interferon, alpha 2	11.0	Publications

Pathways related to nevus according to GeneDecks:

(show top 50)    (show all 123)

id	Pathway	Score	Top Affiliating Genes
1	Pancreatic cancer20	10.8	IKBKG
2	Signal transduction_PTEN pathway41	10.7	PCNA
3	Chronic myeloid leukemia20	10.6	CDKN2A, PIK3CA, BRAF, TP53, HRAS, IKBKG
4	Akt Signaling36	10.6	NRAS, FGFR3, KIT, ITGA6, FGF23, CCND1
5	Acute myeloid leukemia20	10.5	KIT, NRAS, HRAS, PIK3CA, IKBKG, BRAF
6	PPAR Pathway36	10.4	FGF2, KIT, ITGA6, CREBBP, FGF23, FGFR3
7	14-3-3 Induced Intracellular Signaling36	10.2	FGFR3, FGF23, FGF2, NRAS, HRAS, ROR2
8	Melanogenesis20	10.2	KIT, MITF, MC1R, POMC, DCT, TYR
9	Thyroid cancer20	10.1	NRAS, TP53, HRAS, CCND1, CDH1, BRAF
10	Glioblastoma Multiforme36	10.1	APC, NF1, CDK4, HRAS, BRAF, TP53
11	Non-small cell lung cancer20	10.1	EGF, CDKN2A, HRAS, BRAF, PIK3CA, NRAS
12	Signal transduction PTEN pathway10	10.0	EGF, PCNA, PIK3CA, HRAS, PTEN
13	Regulation of actin cytoskeleton20	9.9	BRAF, ITGA6, FGF23, HRAS, EGFR, NRAS
14	Glioma20	9.9	EGFR, HRAS, CDKN2A, BRAF, TP53, PTEN
15	Cytoskeleton remodeling Keratin filaments10	9.9	KRT14, KRT4, KRT13, KRT5, KRT16, KRT17
16	Cytoskeleton remodeling_Keratin filaments41	9.9	KRT4, VIM, KRT14, KRT13, KRT5, KRT16
17	Small cell lung cancer20	9.8	PIK3CA, CDK4, PTEN, TP53, IKBKG, CCND1
18	P2Y Receptor Signaling36	9.8	EGF, EGFR, HRAS, FGFR3, KIT, ROR2
19	Breast Cancer Regulation by Stathmin136	9.7	ROR2, EGF, FGF2, FGF23, EGFR, FGFR3
20	Hepatitis C20	9.7	IFNA2, EGFR, BRAF, EGF, IKBKG, NRAS
21	MAPK signaling pathway20	9.6	IKBKG, FGFR3, TP53, FGF2, BRAF, FGF23
22	Bladder cancer20	9.5	BRAF, CDKN2A, CDK4, CDH1, FGFR3, CCND1
23	PTEN Pathway36	9.5	FGF23, FGFR3, ITGA6, BRAF, KIT, EGF
24	Paxillin Interactions36	9.4	FGF23, FGF2, ITGA6, EGFR, ROR2, EGF
25	Prostate cancer20	9.4	BRAF, PIK3CA, BCL2, IKBKG, HRAS, TP53
26	Melanoma20	9.3	CDK4, EGFR, EGF, PTEN, TP53, HRAS
27	Activation of PKA through GPCR36	9.2	FGF23, FGFR3, PTCH2, NRAS, SMO, CREBBP
28	EGF Pathway36	9.2	BRAF, EGF, EGFR, HRAS, MUC1, IKBKG
29	Endometrial cancer20	9.0	HRAS, NRAS, PTEN, TP53, EGFR, PIK3CA
30	eIF2 Pathway36	8.8	KIT, BRAF, BMP6, FGF2, FGF23, FGFR3
31	Ras Pathway36	8.8	KIT, BRAF, BMP6, ITGA6, FGF2, HRAS
32	ERK Signaling36	8.7	MEPE, FGFR3, FGF23, ITGA6, BMP6, BRAF
33	ILK Signaling36	8.6	KIT, FGF23, CDH1, FGF2, FGFR3, MEPE
34	Focal adhesion20	8.6	EGFR, HRAS, BRAF, EGF, PTEN, TNN
35	GPCR Pathway36	8.6	KIT, BRAF, IKBKG, BMP6, HRAS, FGF2
36	Cellular Apoptosis Pathway36	8.6	BMP6, IKBKG, FGF23, FGF2, CDKN2A, BCL2
37	p53 Mediated Apoptosis36	8.5	BMP6, FGF2, BCL2, KIT, FGFR3, FGF23
38	Nanog in Mammalian ESC Pluripotency36	8.5	ROR2, EGF, NRAS, HRAS, APC, FGFR3
39	Mitochondrial Apoptosis36	8.5	CDKN2A, FGF2, FGF23, FGFR3, TP53, EGFR
40	Phospholipase-C Pathway36	8.4	FGF23, HRAS, MEPE, FGFR3, FGF2, ITGA6
41	Pathways in cancer20	8.4	MITF, PTCH2, NRAS, SMO, CREBBP, EGF
42	Estrogen Pathway36	8.3	KIT, NRAS, CREBBP, FGF2, ROR2, EGFR
43	Pancreatic Adenocarcinoma36	8.3	CDK4, CDKN2A, BCL2, BMP6, BRAF, KIT
44	JAK-STAT Pathway36	8.2	EGFR, HRAS, ROR2, EGF, KIT, BMP6
45	MAPK Signaling36	7.9	EGFR, EGF, NRAS, TP53, HRAS, FGFR3
46	GSK3 Signaling36	7.9	KIT, FGFR3, BMP6, ROR2, CDH1, FGF2
47	TGF-Beta Pathway36	7.8	CREBBP, CDH1, FGF23, FGF2, HRAS, BCL2
48	JNK Pathway36	7.7	BCL2, BMP6, KIT, TP53, FGF2, FGFR3
49	Rho Family GTPases36	7.6	FGF2, BCL2, BMP6, VIM, KIT, CDH1
50	Molecular Mechanisms of Cancer36	7.0	NRAS, EGF, EGFR, ROR2, TP53, FGF2

Compounds related to nevus according to GeneDecks:

(show top 50)    (show all 256)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.2	XRCC5, FGFR3, CRHR1, KRT5, KRT1, KRT10
2	vincristine32 34 9 9	12.8	KIT, FGF2, PTHLH, PLA2G6, POMC
3	rapamycin32 42	10.4	KIT, VIM, BRAF, MYB, CDK4, HRAS
4	mucicarmine32	9.4	VIM, MUC1, S100A1, S100B, KRT14, ACTC1
5	h2o232	9.1	MYB, MC1R, MB, MBP, PLA2G6, ELN
6	crcs32	9.1	PIK3CA, BRAF, MUC1, CDKN2A, CDH1, APC
7	cyclic amp32 18	10.1	BRAF, CDKN2A, CDK4, CDH1, MITF, GRP
8	s 10032	9.0	VIM, MUC1, S100B, F13A1, ACTC1, SYP
9	silver32	9.0	PCNA, S100A1, S100A6, CDKN2A, CD34, CDH1
10	valine32	8.9	KIT, VIM, BRAF, S100B, CDKN2A, CDK4
11	b 72332	8.9	PCNA, VIM, MUC1, S100A1, S100B, CDH1
12	imatinib32 34 9 9	11.6	PIK3CA, KIT, BRAF, MYB, BMP6, BCL2
13	reticulin32	8.6	PCNA, VIM, BMP6, MUC1, S100B, CD34
14	arginine32	8.5	PIK3CA, BRAF, MYB, S100B, CDK4, FLG
15	agar32	8.1	PIK3CA, VIM, BRAF, MUC1, MTAP, CDKN2A
16	cysteine32	8.0	PCNA, MYB, MUC1, S100A1, S100A6, S100B
17	glycogen32 18	8.9	PIK3CA, KIT, VIM, S100A1, S100B, CDK4
18	steroid32	7.9	PIK3CA, KIT, MYB, S100A6, S100B, CDKN2A
19	12-o-tetradecanoylphorbol 13-acetate32	7.9	BRAF, BMP6, CD34, CDK4, CDH1, MITF
20	hematoxylin32	7.8	KIT, PCNA, VIM, MUC1, S100A1, S100B
21	formaldehyde32 18	8.6	KIT, PCNA, SELE, VIM, MUC1, S100B
22	aspartate32	7.6	PCNA, VIM, BRAF, BMP6, S100B, CDKN2A
23	5fluorouracil32	7.6	PIK3CA, KIT, PCNA, SELE, BCL2, MUC1
24	oligonucleotide32	7.5	KIT, PCNA, VIM, BRAF, MYB, BMP6
25	bromodeoxyuridine32	7.4	PIK3CA, PCNA, VIM, MYB, BMP6, S100B
26	vitamin d32	7.3	VIM, BMP6, CDK4, CDH1, FGF23, APC
27	progesterone32 42 9 18 9	11.2	PIK3CA, KIT, PCNA, BRAF, MYB, BCL2
28	genistein32 9 18 9	10.2	PIK3CA, PCNA, SELE, VIM, BCL2, CDKN2A
29	calcium32 9 18 9	10.1	KIT, BRAF, MYB, MUC1, S100A1, S100A6
30	retinoid32	7.1	VIM, MYB, BMP6, BCL2, CDK4, CDH1
31	lipid32	7.1	PIK3CA, SELE, VIM, BRAF, MYB, SCAP
32	thymidine32 18	8.0	PIK3CA, KIT, PCNA, MYB, BMP6, MUC1
33	hydrocortisone32 9 9	9.0	VIM, BMP6, MUC1, FGF2, GRP, PTHLH
34	estrogen32	6.6	PCNA, S100A1, S100A6, S100B, CD34, CDH1
35	paclitaxel32 34 9 9	9.5	PIK3CA, KIT, PCNA, VIM, BRAF, BMP6
36	forskolin32 42 9 9	9.4	VIM, BRAF, BMP6, MUC1, S100B, GRP
37	retinoic acid32 42 18	8.4	PIK3CA, KIT, BRAF, MYB, BMP6, S100A6
38	alanine32	6.2	PCNA, SELE, VIM, BRAF, MYB, BMP6
39	creatinine32	6.1	PCNA, SELE, VIM, BMP6, MUC1, S100B
40	adenylate32	6.1	PIK3CA, SELE, VIM, MYB, MTAP, S100B
41	tamoxifen32 34 9 9	9.0	PIK3CA, PCNA, SELE, VIM, BMP6, BCL2
42	doxorubicin32 34 9 9	8.8	PIK3CA, KIT, SELE, VIM, MYB, BMP6
43	vegf32	5.8	PIK3CA, KIT, PCNA, SELE, BRAF, BCL2
44	dexamethasone32 42 34 9 9	9.8	PIK3CA, PCNA, VIM, MYB, BMP6, BCL2
45	cisplatin32 34 9 9	8.6	PIK3CA, PCNA, BRAF, BMP6, BCL2, MUC1
46	cycloheximide32	5.4	KIT, SELE, VIM, MYB, BMP6, BCL2
47	paraffin32	5.1	KIT, PCNA, VIM, BRAF, BCL2, MUC1
48	testosterone32 9 18 9	8.0	PIK3CA, KIT, PCNA, SELE, VIM, SCAP
49	tyrosine32	4.5	PIK3CA, KIT, BRAF, MYB, BMP6, MUC1
50	serine32	2.7	PIK3CA, KIT, SELE, VIM, BRAF, MYB

Cellular components related to nevus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	melanosome membrane	GO:033162	10.4	DCT, TYR, TYRP1
2	keratin filament	GO:045095	10.1	KRT1, KRT10, KRT4, KRT13, KRT5, KRT14
3	nuclear body	GO:016604	10.0	RREB1, TP53, CDKN2A, CREBBP
4	intermediate filament	GO:005882	9.2	DES, KRT10, VIM, FLG, KRT4, KRT5
5	perinuclear region of cytoplasm	GO:048471	9.0	SELE, XRCC3, S100A6, S100B, CDH1, HRAS
6	cytoplasm	GO:005737	5.7	NF1, KRT17, KRT10, KRT14, EGFR, ACTC1

Biological processes related to nevus according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	activation of MAPKK activity	GO:000186	10.7	NRAS
2	fibroblast growth factor receptor signaling pathway	GO:008543	10.5	HRAS, FGFR3, FGF23, FGF2, NRAS, BRAF
3	Ras protein signal transduction	GO:007265	10.5	RREB1, CDKN2A, NF1, NRAS, TP53, HRAS
4	regulation of long-term neuronal synaptic plasticity	GO:048169	10.5	HRAS, NRAS, NF1, SYP
5	regulation of synaptic transmission, GABAergic	GO:032228	10.4	HRAS, NF1, NRAS
6	melanin biosynthetic process	GO:042438	10.2	TYRP1, MC1R, PMEL
7	MAPK cascade	GO:000165	10.0	FGFR3, EGFR, HRAS, NRAS, NF1
8	melanocyte differentiation	GO:030318	10.0	TYRP1, KIT, BCL2, MITF
9	epidermis development	GO:008544	10.0	KRT1, KRT17, KRT10, KRT15, KRT14, DCT
10	organ morphogenesis	GO:009887	9.9	FOXN1, ELN, HRAS, FGF2, BRAF, BCL2
11	cell proliferation	GO:008283	9.7	PTEN, PCNA, XRCC5, S100B, CD34, MKI67
12	positive regulation of cell proliferation	GO:008284	9.4	CDK4, HRAS, PTEN, PTHLH, NRAS, EGF
13	negative regulation of cell proliferation	GO:008285	9.3	APC, CDKN2A, MXI1, TP53, FGF2, HRAS
14	skeletal system development	GO:001501	9.2	PHEX, BMP6, FGFR3, MEPE, GNAQ, PTHLH
15	positive regulation of transcription, DNA-dependent	GO:045893	8.9	MYB, CDKN2A, CDH1, MITF, FGF2, FGF23
16	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.6	ASXL1, ITGA6, BMP6, MYB, MC1R, CDKN2A

Molecular functions related to nevus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hedgehog receptor activity	GO:008158	10.1	PTCHD4, PTCHD1, PTCH2, PTCHD3, PTCH1
2	S100 protein binding	GO:044548	10.0	S100A6, S100A1, S100B
3	structural constituent of cytoskeleton	GO:005200	9.2	KRT5, KRT16, KRT17, KRT1, KRT15, KRT19
4	identical protein binding	GO:042802	9.2	BCL2, PCNA, SYP, EGFR, TNN, TP53
5	protein binding	GO:005515	3.4	RRAGD, CRHR1, CREBBP, SMO, PTEN, PTCH1