MCID: NVS007
MIFTS: 31

Nevus of Ota

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Nevus of Ota

MalaCards integrated aliases for Nevus of Ota:

Name: Nevus of Ota 56
Nevus Fusculoceruleus Ophthalmomaxillaris 56

Characteristics:

Orphanet epidemiological data:

56
nevus of ota
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

Orphanet 56 ORPHA263425
UMLS via Orphanet 70 C0027961
ICD10 via Orphanet 34 D22.3

Summaries for Nevus of Ota

MalaCards based summary : Nevus of Ota, also known as nevus fusculoceruleus ophthalmomaxillaris, is related to phacomatosis pigmentovascularis and melanoma. An important gene associated with Nevus of Ota is BAP1 (BRCA1 Associated Protein 1), and among its related pathways/superpathways are Development ERBB-family signaling and DNA Double Strand Break Response. Affiliated tissues include skin, eye and pineal, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and digestive/alimentary

Wikipedia : 72 Nevus of Ota (also known as \"congenital melanosis bulbi\", \"nevus fuscoceruleus ophthalmomaxillaris\",... more...

Related Diseases for Nevus of Ota

Diseases related to Nevus of Ota via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
id Related Disease Score Top Affiliating Genes
1 phacomatosis pigmentovascularis 11.3
2 melanoma 10.5
3 meningitis 10.3
4 meningeal melanocytoma 10.3
5 mucositis 10.1
6 choroiditis 10.1
7 mongolian spot 10.1
8 pharynx cancer 10.0 BAP1 TP53
9 cataract 10.0
10 open-angle glaucoma 10.0
11 cleft lip palate dysmorphism kumar type 10.0 BAP1 TP53
12 pilocytic astrocytoma of cerebellum 9.9 BRAF TP53
13 split hand split foot nystagmus 9.9 BRAF TP53
14 coloboma of inferior eyelid 9.8 BRAF TP53
15 lichen nitidus 9.8 BRAF TP53
16 malignant syringoma 9.8 BRAF TP53
17 gliofibroma 9.8 BRAF TP53
18 cutis marmorata telangiectatica congenita 9.8
19 retinitis pigmentosa 9.8
20 arteriovenous malformation 9.8
21 leopard syndrome 9.8
22 cerebritis 9.8
23 retinitis 9.8
24 meningeal melanoma 9.8
25 cerebellar degeneration 9.8
26 weber syndrome 9.8
27 familial episodic pain syndrome 9.8 BRAF TP53
28 sternum cancer 9.8 BRAF TP53
29 juvenile astrocytoma 9.8 BRAF TP53
30 basosquamous carcinoma 9.7 BAP1 BRAF
31 atrophic gastritis 9.7 BRAF TP53
32 arteritic anterior ischemic optic neuropathy 9.7 BRAF TP53
33 non-distal trisomy 10q 9.7 BRAF TP53
34 apocrine adenoma 9.6 BRAF TP53
35 hartnup disorder 9.6 BRAF TP53
36 childhood optic nerve glioma 9.5 BRAF TP53
37 hypohidrosis 9.5 BRAF TP53
38 peritoneal mesothelioma 9.4 BRAF TP53
39 mirror polydactyly-vertebral segmentation-limbs defects syndrome 9.2 BAP1 BRAF TP53
40 dubin-johnson syndrome 9.2 BAP1 BRAF TP53
41 telangiectatic glomangioma 9.2 BAP1 BRAF TP53
42 sertoli-leydig cell tumor 9.2 BRAF TP53
43 sex cord-gonadal stromal tumor 9.1 BAP1 BRAF TP53

Graphical network of the top 20 diseases related to Nevus of Ota:



Diseases related to Nevus of Ota

Symptoms & Phenotypes for Nevus of Ota

GenomeRNAi Phenotypes related to Nevus of Ota according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.8 BAP1 BRAF TP53

MGI Mouse Phenotypes related to Nevus of Ota:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 BAP1 BRAF TP53
2 muscle MP:0005369 9.33 BAP1 BRAF TP53
3 neoplasm MP:0002006 9.13 BAP1 BRAF TP53
4 respiratory system MP:0005388 8.8 BAP1 BRAF TP53

Drugs & Therapeutics for Nevus of Ota

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
2 Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser Treatment Completed NCT00287001

Search NIH Clinical Center for Nevus of Ota

Genetic Tests for Nevus of Ota

Anatomical Context for Nevus of Ota

MalaCards organs/tissues related to Nevus of Ota:

39
Skin, Eye, Pineal, Brain

Publications for Nevus of Ota

Articles related to Nevus of Ota:

(show top 50) (show all 192)
id Title Authors Year
1
Erratum: Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience. ( 28932095 )
2017
2
Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience. ( 28761293 )
2017
3
A split-face comparison of Q-switched Nd:YAG 1064-nm laser for facial rejuvenation in Nevus of Ota patients. ( 28299489 )
2017
4
Clinical profile and triggering factors for acquired, bilateral nevus of Ota-like macules. ( 28122465 )
2017
5
Nevus of Ota (oculodermal melanocytosis) in a dog. ( 28745006 )
2017
6
Ocular Features in a Case of Nevus of Ota. ( 28302248 )
2017
7
Induction of melasma by 1064-nm Q-switched neodymium:yttrium-aluminum-garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population. ( 26777390 )
2016
8
Three cases of symmetrical nevus of Ota and a brief literature review. ( 26889643 )
2016
9
An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota. ( 27699140 )
2016
10
A Retrospective Study on the Characteristics of Treating Nevus of Ota by 1064-nm Q-switched Neodymium-doped Yttrium Aluminum Garnet Laser. ( 27293272 )
2016
11
Comparison of clinical efficacy and complications between Q-switched alexandrite laser and Q-switched Nd:YAG laser on nevus of Ota: a systematic review and meta-analysis. ( 26861980 )
2016
12
Nevus of Ota. ( 27734644 )
2016
13
Analysis of 28 Chinese Cases of Bilateral Nevus of Ota and Therapeutic Results With the Q-Switched Alexandrite Laser. ( 26808181 )
2016
14
Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations. ( 26701415 )
2016
15
Primary melanoma of the leptomeninges with bap1 expression-loss in the setting of a nevus of ota: A clinical, morphological and genetic study of 2 cases. ( 26834043 )
2016
16
Recurrence of Nevus of Ota after Successful Laser Treatment: Possible Role of Dermal Stem Cells. ( 27746651 )
2016
17
Phakomatosis pigmentovascularis type IIb: A case with Klippel-TrenA!unay syndrome and extensive dermal melanocytosis as nevus of Ota, nevus of Ito and ectopic Mongolian spots. ( 27374914 )
2016
18
Lasers and nevus of Ota: a comprehensive review. ( 26563954 )
2015
19
Cerebellar meningeal melanocytoma associated with nevus of Ota: An extremely rare case. ( 26259856 )
2015
20
The case of a boy with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita: a unique instance of phacomatosis pigmentovascularis. ( 26312661 )
2015
21
A randomized, split-face clinical trial of Q-switched alexandrite laser versus Q-switched Nd:YAG laser in the treatment of bilateral nevus of Ota. ( 25968166 )
2015
22
Intermediate-grade meningeal melanocytoma associated with nevus of Ota: a case report and review of the literature. ( 25933209 )
2015
23
Giant nevus of Ota. ( 26265645 )
2015
24
Nevus of Ota/oculodermal melancytosis: a rare report of an oral mucosal lesion involving the hard palate. ( 26682294 )
2015
25
Beneficial effects of early treatment of nevus of Ota with low-fluence 1,064-nm Q-switched Nd:YAG laser. ( 25485806 )
2015
26
Treatment of Nevus of Ota With a Picosecond 755-nm Alexandrite Laser. ( 25760558 )
2015
27
Factors affecting response and laser sessions and complications in Nevus of Ota treated by Q- switched alexandrite laser: A retrospective study. ( 25747257 )
2015
28
Giant Blue Nevus: A New Association to Nevus of Ota. ( 26121271 )
2015
29
Spontaneous partial regression of nevus of Ota with the development of vitiligo. ( 26474418 )
2015
30
Animal-type malignant melanoma associated with nevus of Ota in the orbit of a Japanese woman: a case report. ( 24686419 )
2014
31
Centrally located acquired bilateral nevus of ota-like macules: a bizarre pattern. ( 25823087 )
2014
32
Pigment reduction in nevus of Ota following leech therapy. ( 24948864 )
2014
33
Nevus of ota. ( 24986303 )
2014
34
A retrospective analysis of the clinical efficacies of Q-switched Alexandrite and Q-switched Nd:YAG lasers in the treatment of nevus of Ota in Korean patients. ( 24888365 )
2014
35
Orbital melanocytoma completely resected with conservative surgery in association with ipsilateral nevus of Ota: Report of a case and review of the literature. ( 24989678 )
2014
36
Bilateral familial nevus of Ota. ( 25448143 )
2014
37
Acquired Bilateral Nevus of ota-like Macules with Mucosal Involvement: A New Variant of Hori's Nevus. ( 24891664 )
2014
38
A retrospective study on laser treatment of nevus of Ota in Chinese children--a seven-year follow-up. ( 24684590 )
2014
39
An unusual case of nevus of Ota combined with nevus spilus. ( 24962014 )
2014
40
BRAF V600E mutation in two distinct meningeal melanocytomas associated with a nevus of Ota. ( 24493731 )
2014
41
Comparison of acquired bilateral nevus of Ota-like macules in men and women. ( 25035355 )
2014
42
Assessment of the Response and Improving Outcomes of Nevus of Ota with Q-switched Nd : Yag Laser. ( 24470714 )
2013
43
Orbital malignant melanoma associated with nevus of Ota. ( 23571263 )
2013
44
A new classification of nevus of Ota. ( 24157155 )
2013
45
Unilateral Nevus of Ota with Bilateral Nevus of Ito and Palatal Lesion: A Case Report with a Proposed Clinical Modification of Tanino's Classification. ( 23918999 )
2013
46
Melanin Index in Assessing the Treatment Efficacy of 1064 nm Q Switched Nd-Yag Laser in Nevus of Ota. ( 24470713 )
2013
47
Microsurgical treatment of meningeal malignant melanoma accompanied by nevus of Ota: two case reports and a literature review. ( 24162444 )
2013
48
Unilateral open-angle glaucoma associated with the ipsilateral nevus of ota. ( 23781367 )
2013
49
Malignant melanoma from a nevus of Ota in a pediatric patient with fatal outcome. ( 24034399 )
2013
50
Pruritic acquired nevus of Ota. ( 24060704 )
2013

Variations for Nevus of Ota

Expression for Nevus of Ota

Search GEO for disease gene expression data for Nevus of Ota.

Pathways for Nevus of Ota

Pathways related to Nevus of Ota according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.05 BRAF TP53
2
Show member pathways
11.9 BAP1 TP53
3
Show member pathways
11.84 BRAF TP53
4 11.82 BRAF TP53
5 11.71 BRAF TP53
6
Show member pathways
11.68 BRAF TP53
7
Show member pathways
11.66 BRAF TP53
8 11.64 BRAF TP53
9
Show member pathways
11.61 BRAF TP53
10 11.49 BRAF TP53
11
Show member pathways
11.42 BRAF TP53
12 11.3 BRAF TP53
13 11.18 BRAF TP53
14 10.89 BRAF TP53
15 10.49 BRAF TP53

GO Terms for Nevus of Ota

Cellular components related to Nevus of Ota according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 8.8 BAP1 BRAF TP53

Biological processes related to Nevus of Ota according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to drug GO:0035690 8.62 BRAF TP53

Sources for Nevus of Ota

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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