MCID: NVS007
MIFTS: 35

Nevus of Ota

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Nevus of Ota

MalaCards integrated aliases for Nevus of Ota:

Name: Nevus of Ota 55
Nevus Fusculoceruleus Ophthalmomaxillaris 55

Characteristics:

Orphanet epidemiological data:

55
nevus of ota
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare skin diseases


External Ids:

Orphanet 55 ORPHA263425
UMLS via Orphanet 70 C0027961
ICD10 via Orphanet 33 D22.3

Summaries for Nevus of Ota

MalaCards based summary : Nevus of Ota, also known as nevus fusculoceruleus ophthalmomaxillaris, is related to melanoma and phacomatosis pigmentovascularis. An important gene associated with Nevus of Ota is BAP1 (BRCA1 Associated Protein 1), and among its related pathways/superpathways are Development EGFR signaling pathway and DNA Double Strand Break Response. Affiliated tissues include skin, eye and pineal, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and digestive/alimentary

Wikipedia : 72 Nevus of Ota (also known as \"congenital melanosis bulbi\", \"nevus fuscoceruleus ophthalmomaxillaris\",... more...

Related Diseases for Nevus of Ota

Diseases related to Nevus of Ota via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 melanoma 29.8 BAP1 BRAF TP53
2 phacomatosis pigmentovascularis 11.4
3 meningitis 10.4
4 meningeal melanocytoma 10.3
5 choroiditis 10.2
6 mucositis 10.2
7 mongolian spot 10.1
8 tièche-jadassohn nevus 10.1
9 open-angle glaucoma 10.0
10 branchiootic syndrome 1 10.0
11 cataract 10.0
12 sensory system cancer 10.0 BAP1 TP53
13 clear cell renal cell carcinoma 10.0 BAP1 TP53
14 pigmentation disease 9.9
15 arteriovenous malformations of the brain 9.9
16 arteriovenous malformation 9.9
17 lentigines 9.9
18 neurofibromatosis, type iv, of riccardi 9.9
19 leopard syndrome 9.9
20 nevus anemicus 9.9
21 dowling-degos disease 1 9.9
22 cerebritis 9.9
23 sturge-weber syndrome 9.9
24 retinitis 9.9
25 cutis marmorata telangiectatica congenita 9.9
26 retinitis pigmentosa 9.9
27 aging 9.9
28 meningeal melanoma 9.9
29 leber congenital amaurosis 4 9.9
30 cerebellar degeneration 9.9
31 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9
32 weber syndrome 9.9
33 cerebellar astrocytoma 9.9 BRAF TP53
34 spitz nevus 9.9 BRAF TP53
35 hyperplastic polyposis syndrome 9.9 BRAF TP53
36 lip cancer 9.9 BRAF TP53
37 mature teratoma 9.9 BRAF TP53
38 pleomorphic xanthoastrocytoma 9.8 BRAF TP53
39 familial colorectal cancer 9.8 BRAF TP53
40 ganglioglioma 9.8 BRAF TP53
41 giant cell glioblastoma 9.8 BRAF TP53
42 skin squamous cell carcinoma 9.8 BRAF TP53
43 skin melanoma 9.8 BRAF TP53
44 colorectal adenocarcinoma 9.8 BRAF TP53
45 bladder urothelial carcinoma 9.8 BRAF TP53
46 differentiated thyroid carcinoma 9.8 BRAF TP53
47 lung squamous cell carcinoma 9.7 BRAF TP53
48 myeloma, multiple 9.7 BRAF TP53
49 lynch syndrome 9.7 BRAF TP53
50 adenoma 9.7 BRAF TP53

Graphical network of the top 20 diseases related to Nevus of Ota:



Diseases related to Nevus of Ota

Symptoms & Phenotypes for Nevus of Ota

GenomeRNAi Phenotypes related to Nevus of Ota according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.8 BAP1 BRAF TP53

MGI Mouse Phenotypes related to Nevus of Ota:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 BAP1 BRAF TP53
2 muscle MP:0005369 9.33 BAP1 BRAF TP53
3 neoplasm MP:0002006 9.13 BAP1 BRAF TP53
4 respiratory system MP:0005388 8.8 BAP1 BRAF TP53

Drugs & Therapeutics for Nevus of Ota

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
2 Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser Treatment Completed NCT00287001

Search NIH Clinical Center for Nevus of Ota

Genetic Tests for Nevus of Ota

Anatomical Context for Nevus of Ota

MalaCards organs/tissues related to Nevus of Ota:

38
Skin, Eye, Pineal, Brain

Publications for Nevus of Ota

Articles related to Nevus of Ota:

(show top 50) (show all 196)
# Title Authors Year
1
A study on the clinical characteristics of treating nevus of Ota by Q-switched Nd:YAG laser. ( 28986651 )
2018
2
Successful and safe use of Q-switched lasers in the treatment of nevus of Ota in children with phototypes IV-VI. ( 29131366 )
2018
3
Examination of the melanocytes of the Nevus of Ota with in vivo reflectance confocal microscopy: 15 cases. ( 29314292 )
2018
4
A Split-Face, Single-Blinded, Randomized Controlled Comparison of Alexandrite 755 nm Picosecond Laser vs. Alexandrite 755 nm Nanosecond Laser in the Treatment of Acquired Bilateral Nevus of Ota-like Macules (ABNOM). ( 29288102 )
2017
5
Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience. ( 28761293 )
2017
6
Ocular Features in a Case of Nevus of Ota. ( 28302248 )
2017
7
Nevus of Ota (oculodermal melanocytosis) in a dog. ( 28745006 )
2017
8
Erratum: Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience. ( 28932095 )
2017
9
A split-face comparison of Q-switched Nd:YAG 1064-nm laser for facial rejuvenation in Nevus of Ota patients. ( 28299489 )
2017
10
Clinical profile and triggering factors for acquired, bilateral nevus of Ota-like macules. ( 28122465 )
2017
11
Nevus of Ota. ( 27734644 )
2016
12
Recurrence of Nevus of Ota after Successful Laser Treatment: Possible Role of Dermal Stem Cells. ( 27746651 )
2016
13
Comparison of clinical efficacy and complications between Q-switched alexandrite laser and Q-switched Nd:YAG laser on nevus of Ota: a systematic review and meta-analysis. ( 26861980 )
2016
14
Phakomatosis pigmentovascularis type IIb: A case with Klippel-TrenA!unay syndrome and extensive dermal melanocytosis as nevus of Ota, nevus of Ito and ectopic Mongolian spots. ( 27374914 )
2016
15
Analysis of 28 Chinese Cases of Bilateral Nevus of Ota and Therapeutic Results With the Q-Switched Alexandrite Laser. ( 26808181 )
2016
16
Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations. ( 26701415 )
2016
17
A Retrospective Study on the Characteristics of Treating Nevus of Ota by 1064-nm Q-switched Neodymium-doped Yttrium Aluminum Garnet Laser. ( 27293272 )
2016
18
Three cases of symmetrical nevus of Ota and a brief literature review. ( 26889643 )
2016
19
Primary melanoma of the leptomeninges with bap1 expression-loss in the setting of a nevus of ota: A clinical, morphological and genetic study of 2 cases. ( 26834043 )
2016
20
Induction of melasma by 1064-nm Q-switched neodymium:yttrium-aluminum-garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population. ( 26777390 )
2016
21
An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota. ( 27699140 )
2016
22
Intermediate-grade meningeal melanocytoma associated with nevus of Ota: a case report and review of the literature. ( 25933209 )
2015
23
Beneficial effects of early treatment of nevus of Ota with low-fluence 1,064-nm Q-switched Nd:YAG laser. ( 25485806 )
2015
24
Nevus of Ota/oculodermal melancytosis: a rare report of an oral mucosal lesion involving the hard palate. ( 26682294 )
2015
25
Giant nevus of Ota. ( 26265645 )
2015
26
A randomized, split-face clinical trial of Q-switched alexandrite laser versus Q-switched Nd:YAG laser in the treatment of bilateral nevus of Ota. ( 25968166 )
2015
27
Lasers and nevus of Ota: a comprehensive review. ( 26563954 )
2015
28
Spontaneous partial regression of nevus of Ota with the development of vitiligo. ( 26474418 )
2015
29
Giant Blue Nevus: A New Association to Nevus of Ota. ( 26121271 )
2015
30
Factors affecting response and laser sessions and complications in Nevus of Ota treated by Q- switched alexandrite laser: A retrospective study. ( 25747257 )
2015
31
Treatment of Nevus of Ota With a Picosecond 755-nm Alexandrite Laser. ( 25760558 )
2015
32
The case of a boy with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita: a unique instance of phacomatosis pigmentovascularis. ( 26312661 )
2015
33
Cerebellar meningeal melanocytoma associated with nevus of Ota: An extremely rare case. ( 26259856 )
2015
34
A retrospective study on laser treatment of nevus of Ota in Chinese children--a seven-year follow-up. ( 24684590 )
2014
35
BRAF V600E mutation in two distinct meningeal melanocytomas associated with a nevus of Ota. ( 24493731 )
2014
36
Nevus of ota. ( 24986303 )
2014
37
Animal-type malignant melanoma associated with nevus of Ota in the orbit of a Japanese woman: a case report. ( 24686419 )
2014
38
Centrally located acquired bilateral nevus of ota-like macules: a bizarre pattern. ( 25823087 )
2014
39
Pigment reduction in nevus of Ota following leech therapy. ( 24948864 )
2014
40
A retrospective analysis of the clinical efficacies of Q-switched Alexandrite and Q-switched Nd:YAG lasers in the treatment of nevus of Ota in Korean patients. ( 24888365 )
2014
41
Orbital melanocytoma completely resected with conservative surgery in association with ipsilateral nevus of Ota: Report of a case and review of the literature. ( 24989678 )
2014
42
Comparison of acquired bilateral nevus of Ota-like macules in men and women. ( 25035355 )
2014
43
Acquired Bilateral Nevus of ota-like Macules with Mucosal Involvement: A New Variant of Hori's Nevus. ( 24891664 )
2014
44
An unusual case of nevus of Ota combined with nevus spilus. ( 24962014 )
2014
45
Bilateral familial nevus of Ota. ( 25448143 )
2014
46
A new classification of nevus of Ota. ( 24157155 )
2013
47
Melanin Index in Assessing the Treatment Efficacy of 1064 nm Q Switched Nd-Yag Laser in Nevus of Ota. ( 24470713 )
2013
48
Assessment of the Response and Improving Outcomes of Nevus of Ota with Q-switched Nd : Yag Laser. ( 24470714 )
2013
49
Malignant melanoma from a nevus of Ota in a pediatric patient with fatal outcome. ( 24034399 )
2013
50
Unilateral Nevus of Ota with Bilateral Nevus of Ito and Palatal Lesion: A Case Report with a Proposed Clinical Modification of Tanino's Classification. ( 23918999 )
2013

Variations for Nevus of Ota

Expression for Nevus of Ota

Search GEO for disease gene expression data for Nevus of Ota.

Pathways for Nevus of Ota

Pathways related to Nevus of Ota according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.03 BRAF TP53
2
Show member pathways
11.88 BAP1 TP53
3 11.82 BRAF TP53
4
Show member pathways
11.79 BRAF TP53
5 11.71 BRAF TP53
6
Show member pathways
11.68 BRAF TP53
7 11.64 BRAF TP53
8
Show member pathways
11.62 BRAF TP53
9
Show member pathways
11.59 BRAF TP53
10 11.49 BRAF TP53
11
Show member pathways
11.42 BRAF TP53
12 11.3 BRAF TP53
13 11.18 BRAF TP53
14 10.85 BRAF TP53
15 10.49 BRAF TP53

GO Terms for Nevus of Ota

Cellular components related to Nevus of Ota according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 8.8 BAP1 BRAF TP53

Biological processes related to Nevus of Ota according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to drug GO:0035690 8.96 BRAF TP53
2 response to inorganic substance GO:0010035 8.62 BAP1 TP53

Sources for Nevus of Ota

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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