MCID: NVS007
MIFTS: 33

Nevus of Ota malady

Categories: Skin diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs

Aliases & Classifications for Nevus of Ota

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Sources:
31ICD10 via Orphanet, 54Orphanet, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Nevus of Ota:

Name: Nevus of Ota 54
 
Nevus Fusculoceruleus Ophthalmomaxillaris 54

Characteristics:

Orphanet epidemiological data:

54
nevus fusculoceruleus ophthalmomaxillaris:
Inheritance: Not applicable; Age of onset: All ages

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 31
Orphanet: 54 
Rare skin diseases


External Ids:

Orphanet54 ORPHA263425
ICD10 via Orphanet31 D22.3
UMLS via Orphanet69 C0027961

Summaries for Nevus of Ota

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Wikipedia:71 Nevus of Ota (also known as \"congenital melanosis bulbi\", \"nevus fuscoceruleus ophthalmomaxillaris\",... more...

MalaCards based summary: Nevus of Ota, also known as nevus fusculoceruleus ophthalmomaxillaris, is related to phacomatosis pigmentovascularis and meningitis. An important gene associated with Nevus of Ota is BAP1 (BRCA1 Associated Protein 1), and among its related pathways are MAPK Signaling: Mitogen Stimulation Pathway and mTOR Pathway. Affiliated tissues include skin, eye and pineal, and related mouse phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and embryo.

Related Diseases for Nevus of Ota

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Diseases related to Nevus of Ota via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
idRelated DiseaseScoreTop Affiliating Genes
1phacomatosis pigmentovascularis11.3
2meningitis10.3
3meningeal melanocytoma10.3
4choroiditis10.1
5cataract10.0
6open-angle glaucoma10.0
7verloove vanhorick brubakk syndrome10.0BAP1, TP53
8duodenal somatostatinoma9.9BAP1, TP53
9tumor predisposition syndrome9.9BAP1, TP53
10ciliary body spindle cell melanoma9.9BAP1, TP53
11pleomorphic xanthoastrocytoma9.8BRAF, TP53
12split hand split foot malformation autosomal recessive9.8BRAF, TP53
13multiple carboxylase deficiency9.8BRAF, TP53
14diencephalic astrocytomas9.8BRAF, TP53
15cutis marmorata telangiectatica congenita9.8
16retinitis pigmentosa9.8
17arteriovenous malformation9.8
18cerebritis9.8
19retinitis9.8
20meningeal melanoma9.8
21cerebellar degeneration9.8
22weber syndrome9.8
23mediastinum teratoma9.8BRAF, TP53
24mixed epithelial stromal tumour9.8BRAF, TP53
25kidney benign neoplasm9.8BRAF, TP53
26learning disability9.8BRAF, TP53
27arteritic anterior ischemic optic neuropathy9.8BRAF, TP53
28prostate cancer, hereditary, x-linked 19.7BRAF, TP53
29atrial standstill9.7BRAF, TP53
30hidrocystoma9.6BRAF, TP53
31childhood optic tract astrocytoma9.6BRAF, TP53
32pericarditis9.5BRAF, TP53
33miliaria rubra9.5BRAF, TP53
34mixed germ cell-sex cord neoplasm9.5BRAF, TP53
35dubin-johnson syndrome9.3BAP1, BRAF, TP53
36smoking as a quantitative trait locus 19.3BRAF, TP53

Graphical network of the top 20 diseases related to Nevus of Ota:



Diseases related to nevus of ota

Symptoms & Phenotypes for Nevus of Ota

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GenomeRNAi Phenotypes related to Nevus of Ota according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-39.3BAP1, BRAF, TP53

MGI Mouse Phenotypes related to Nevus of Ota according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.3BAP1, BRAF, TP53
2MP:00053699.2BAP1, BRAF, TP53
3MP:00020068.5BAP1, BRAF, TP53

Drugs & Therapeutics for Nevus of Ota

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Drugs for Nevus of Ota (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LiraglutideapprovedPhase 3315204656-20-2
Synonyms:
204656-20-2
Arg34Lys26-(N-ε-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]
C439759
Liraglutida
Liraglutida [INN-Spanish]
Liraglutide
Liraglutide [USAN:INN]
Liraglutide recombinant
Liraglutidum
Liraglutidum [INN-Latin]
N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)GLP-1-(7-37)-peptide
 
N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide
NN 2211
NN-2211
NN2211
NNC 90-1170
N²⁶-(N-Hexadecanoyl-L-gamma-glutamyl)-[34-L-arginine]glucagon-like peptide 1-(7-37)-peptide
N²⁶-(hexadecanoyl-gamma-glutamyle)-[34-arginine]GLP-1-(7-37)-peptide
UNII-839I73S42A
Victoza
nn 2211
nn2211
victoza
2Hormone AntagonistsPhase 312778
3Hypoglycemic AgentsPhase 35733
4IncretinsPhase 31537
5Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 312767
6HormonesPhase 313979
7Sitagliptin PhosphatePhase 3416
8
protease inhibitorsPhase 35320
Synonyms:
 
protease inhibitors
9Dipeptidyl-Peptidase IV InhibitorsPhase 3846
10HIV Protease InhibitorsPhase 35319

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dose-response, Safety and Efficacy of Oral Semaglutide Versus Placebo and Versus Liraglutide, All as Monotherapy in Japanese Subjects With Type 2 DiabetesRecruitingNCT03018028Phase 3
2Efficacy and Long-term Safety of Oral Semaglutide Versus Sitagliptin in Subjects With Type 2 DiabetesActive, not recruitingNCT02607865Phase 3
3Optical Clearing of the Skin in Conjunction With Laser TreatmentsCompletedNCT00580736Phase 1
4Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser TreatmentCompletedNCT00287001

Search NIH Clinical Center for Nevus of Ota

Genetic Tests for Nevus of Ota

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Anatomical Context for Nevus of Ota

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MalaCards organs/tissues related to Nevus of Ota:

36
Skin, Eye, Pineal, Brain

Publications for Nevus of Ota

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Articles related to Nevus of Ota:

(show top 50)    (show all 186)
idTitleAuthorsYear
1
Comparison of clinical efficacy and complications between Q-switched alexandrite laser and Q-switched Nd:YAG laser on nevus of Ota: a systematic review and meta-analysis. (26861980)
2016
2
An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota. (27699140)
2016
3
Nevus of Ota. (27734644)
2016
4
Primary melanoma of the leptomeninges with bap1 expression-loss in the setting of a nevus of ota: A clinical, morphological and genetic study of 2 cases. (26834043)
2016
5
A Retrospective Study on the Characteristics of Treating Nevus of Ota by 1064-nm Q-switched Neodymium-doped Yttrium Aluminum Garnet Laser. (27293272)
2016
6
Recurrence of Nevus of Ota after Successful Laser Treatment: Possible Role of Dermal Stem Cells. (27746651)
2016
7
Induction of melasma by 1064-nm Q-switched neodymium:yttrium-aluminum-garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population. (26777390)
2016
8
Phakomatosis pigmentovascularis type IIb: A case with Klippel-TrenA!unay syndrome and extensive dermal melanocytosis as nevus of Ota, nevus of Ito and ectopic Mongolian spots. (27374914)
2016
9
Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations. (26701415)
2016
10
Three cases of symmetrical nevus of Ota and a brief literature review. (26889643)
2016
11
Analysis of 28 Chinese Cases of Bilateral Nevus of Ota and Therapeutic Results With the Q-Switched Alexandrite Laser. (26808181)
2016
12
Factors affecting response and laser sessions and complications in Nevus of Ota treated by Q- switched alexandrite laser: A retrospective study. (25747257)
2015
13
Giant nevus of Ota. (26265645)
2015
14
Treatment of Nevus of Ota With a Picosecond 755-nm Alexandrite Laser. (25760558)
2015
15
Beneficial effects of early treatment of nevus of Ota with low-fluence 1,064-nm Q-switched Nd:YAG laser. (25485806)
2015
16
Spontaneous partial regression of nevus of Ota with the development of vitiligo. (26474418)
2015
17
Lasers and nevus of Ota: a comprehensive review. (26563954)
2015
18
The case of a boy with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita: a unique instance of phacomatosis pigmentovascularis. (26312661)
2015
19
Intermediate-grade meningeal melanocytoma associated with nevus of Ota: a case report and review of the literature. (25933209)
2015
20
Nevus of Ota/oculodermal melancytosis: a rare report of an oral mucosal lesion involving the hard palate. (26682294)
2015
21
A randomized, split-face clinical trial of Q-switched alexandrite laser versus Q-switched Nd:YAG laser in the treatment of bilateral nevus of Ota. (25968166)
2015
22
Cerebellar meningeal melanocytoma associated with nevus of Ota: An extremely rare case. (26259856)
2015
23
Giant Blue Nevus: A New Association to Nevus of Ota. (26121271)
2015
24
Acquired Bilateral Nevus of ota-like Macules with Mucosal Involvement: A New Variant of Hori's Nevus. (24891664)
2014
25
Nevus of ota. (24986303)
2014
26
An unusual case of nevus of Ota combined with nevus spilus. (24962014)
2014
27
Orbital melanocytoma completely resected with conservative surgery in association with ipsilateral nevus of Ota: Report of a case and review of the literature. (24989678)
2014
28
Animal-type malignant melanoma associated with nevus of Ota in the orbit of a Japanese woman: a case report. (24686419)
2014
29
Bilateral familial nevus of Ota. (25448143)
2014
30
Centrally located acquired bilateral nevus of ota-like macules: a bizarre pattern. (25823087)
2014
31
Comparison of acquired bilateral nevus of Ota-like macules in men and women. (25035355)
2014
32
BRAF V600E mutation in two distinct meningeal melanocytomas associated with a nevus of Ota. (24493731)
2014
33
A retrospective analysis of the clinical efficacies of Q-switched Alexandrite and Q-switched Nd:YAG lasers in the treatment of nevus of Ota in Korean patients. (24888365)
2014
34
Pigment reduction in nevus of Ota following leech therapy. (24948864)
2014
35
A retrospective study on laser treatment of nevus of Ota in Chinese children--a seven-year follow-up. (24684590)
2014
36
Unilateral open-angle glaucoma associated with the ipsilateral nevus of ota. (23781367)
2013
37
Orbital malignant melanoma associated with nevus of Ota. (23571263)
2013
38
Malignant melanoma from a nevus of Ota in a pediatric patient with fatal outcome. (24034399)
2013
39
A new classification of nevus of Ota. (24157155)
2013
40
Microsurgical treatment of meningeal malignant melanoma accompanied by nevus of Ota: two case reports and a literature review. (24162444)
2013
41
Treatment of nevus of Ota using low fluence Q-switched Nd:YAG laser. (23834371)
2013
42
Melanin Index in Assessing the Treatment Efficacy of 1064 nm Q Switched Nd-Yag Laser in Nevus of Ota. (24470713)
2013
43
Unilateral Nevus of Ota with Bilateral Nevus of Ito and Palatal Lesion: A Case Report with a Proposed Clinical Modification of Tanino's Classification. (23918999)
2013
44
Assessment of the Response and Improving Outcomes of Nevus of Ota with Q-switched Nd : Yag Laser. (24470714)
2013
45
Pruritic acquired nevus of Ota. (24060704)
2013
46
Are Q-switched lasers for Nevus of Ota really effective in pigmented skin? (22421653)
2012
47
Nevus of Ota: morphological patterns and distribution in 47 Yemeni cases. (21967654)
2012
48
Report of rare palatal expression of Nevus of Ota with amendment of Tanino's classification. (22484884)
2011
49
A retrospective study of q-switched alexandrite laser in treating nevus of ota. (21790845)
2011
50
Intracranial meningeal melanocytoma associated with nevus of Ota. (21924617)
2011

Variations for Nevus of Ota

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Expression for genes affiliated with Nevus of Ota

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Search GEO for disease gene expression data for Nevus of Ota.

Pathways for genes affiliated with Nevus of Ota

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Pathways related to Nevus of Ota according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathwaysScoreTop Affiliating Genes
1
MAPK Signaling: Mitogen Stimulation Pathway59
Show member pathways
9.1BRAF, TP53
2
mTOR Pathway66
Show member pathways
9.1BRAF, TP53
3
Integrated Breast Cancer Pathway42
9.1BRAF, TP53
4
Colorectal Cancer Metastasis58
9.1BRAF, TP53
5
Proteoglycans in cancer34
9.1BRAF, TP53
6
Endometrial cancer34
Show member pathways
9.1BRAF, TP53
7
ErbB signaling pathway42 34
Show member pathways
9.1BRAF, TP53
8
NGF Pathway58
Show member pathways
9.1BRAF, TP53
9
Chronic myeloid leukemia34
Show member pathways
9.1BRAF, TP53
10
Senescence and Autophagy42
9.1BRAF, TP53
11
MAPK Signaling: Oxidative Stress Pathway59
9.1BRAF, TP53
12
Bladder cancer34
9.1BRAF, TP53
13
Glioblastoma Multiforme58
9.1BRAF, TP53
14
MAPK Pathway66
Show member pathways
9.1BRAF, TP53
15
G-protein signaling Ras family GTPases in kinase cascades (scheme)65
Show member pathways
9.1BRAF, TP53
16
Hepatitis C34
9.1BRAF, TP53
17
Thyroid cancer34
9.1BRAF, TP53

GO Terms for genes affiliated with Nevus of Ota

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Biological processes related to Nevus of Ota according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular response to drugGO:00356909.1BRAF, TP53

Sources for Nevus of Ota

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z