MCID: NVS007
MIFTS: 34

Nevus of Ota malady

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Nevus of Ota

Aliases & Descriptions for Nevus of Ota:

Name: Nevus of Ota 56
Nevus Fusculoceruleus Ophthalmomaxillaris 56

Characteristics:

Orphanet epidemiological data:

56
nevus of ota
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare skin diseases


External Ids:

Orphanet 56 ORPHA263425
ICD10 via Orphanet 34 D22.3
UMLS via Orphanet 70 C0027961

Summaries for Nevus of Ota

MalaCards based summary : Nevus of Ota, also known as nevus fusculoceruleus ophthalmomaxillaris, is related to phacomatosis pigmentovascularis and melanoma. An important gene associated with Nevus of Ota is BAP1 (BRCA1 Associated Protein 1), and among its related pathways/superpathways are DNA Double Strand Break Response and Endometrial cancer. The drugs Liraglutide and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and pineal, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and digestive/alimentary

Wikipedia : 71 Nevus of Ota (also known as \"congenital melanosis bulbi\", \"nevus fuscoceruleus ophthalmomaxillaris\",... more...

Related Diseases for Nevus of Ota

Diseases related to Nevus of Ota via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
id Related Disease Score Top Affiliating Genes
1 phacomatosis pigmentovascularis 11.3
2 melanoma 10.5
3 meningitis 10.3
4 meningeal melanocytoma 10.3
5 choroiditis 10.1
6 mucositis 10.1
7 mongolian spot 10.0
8 cleft palate cardiac defect ectrodactyly 10.0 BAP1 TP53
9 pineal gland astrocytoma 10.0 BRAF TP53
10 spondylarthropathy 10.0 BRAF TP53
11 tmem70 defect 10.0 BRAF TP53
12 cataract 10.0
13 open-angle glaucoma 10.0
14 infantile thalamic degeneration 10.0 BRAF TP53
15 scarlet fever 10.0 BRAF TP53
16 familial hypopituitarism 9.9 BRAF TP53
17 inhibited male orgasm 9.9 BRAF TP53
18 brain stem astrocytic neoplasm 9.9 BRAF TP53
19 amyloid tumor 9.9 BRAF TP53
20 inner ear cancer 9.9 BRAF TP53
21 lattice corneal dystrophy 9.9 BRAF TP53
22 oral squamous cell carcinoma 9.9 BRAF TP53
23 non-distal monosomy 10q 9.9 BRAF TP53
24 hidradenoma 9.9 BRAF TP53
25 pulmonary fibrosis, idiopathic 9.8 BRAF TP53
26 arteriovenous malformation 9.8
27 leopard syndrome 9.8
28 cerebritis 9.8
29 retinitis 9.8
30 meningeal melanoma 9.8
31 neurofibromatosis 9.8
32 cutis marmorata telangiectatica congenita 9.8
33 cerebellar degeneration 9.8
34 retinitis pigmentosa 9.8
35 weber syndrome 9.8
36 pediatric germ cell cancer 9.8 BAP1 BRAF
37 peritoneal mesothelioma 9.8 BRAF TP53
38 well-differentiated thymic neuroendocrine carcinoma 9.7 BAP1 BRAF TP53
39 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 3 9.7 BAP1 BRAF TP53
40 testicular cancer 9.7 BRAF TP53

Graphical network of the top 20 diseases related to Nevus of Ota:



Diseases related to Nevus of Ota

Symptoms & Phenotypes for Nevus of Ota

GenomeRNAi Phenotypes related to Nevus of Ota according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.8 BAP1 BRAF TP53

MGI Mouse Phenotypes related to Nevus of Ota:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 BRAF TP53 BAP1
2 embryo MP:0005380 9.43 BRAF TP53 BAP1
3 muscle MP:0005369 9.33 BRAF TP53 BAP1
4 neoplasm MP:0002006 9.13 TP53 BAP1 BRAF
5 respiratory system MP:0005388 8.8 TP53 BAP1 BRAF

Drugs & Therapeutics for Nevus of Ota

Drugs for Nevus of Ota (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Liraglutide Approved Phase 3 204656-20-2
2 Hormone Antagonists Phase 3
3 Hormones Phase 3
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
5 Hypoglycemic Agents Phase 3
6 Incretins Phase 3
7
protease inhibitors Phase 3
8 Sitagliptin Phosphate Phase 3
9 HIV Protease Inhibitors Phase 3
10 Dipeptidyl-Peptidase IV Inhibitors Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 Dose-response, Safety and Efficacy of Oral Semaglutide Versus Placebo and Versus Liraglutide, All as Monotherapy in Japanese Subjects With Type 2 Diabetes Recruiting NCT03018028 Phase 3
2 Efficacy and Long-term Safety of Oral Semaglutide Versus Sitagliptin in Subjects With Type 2 Diabetes Active, not recruiting NCT02607865 Phase 3
3 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
4 Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser Treatment Completed NCT00287001

Search NIH Clinical Center for Nevus of Ota

Genetic Tests for Nevus of Ota

Anatomical Context for Nevus of Ota

MalaCards organs/tissues related to Nevus of Ota:

39
Skin, Eye, Pineal, Brain

Publications for Nevus of Ota

Articles related to Nevus of Ota:

(show top 50) (show all 186)
id Title Authors Year
1
Recurrence of Nevus of Ota after Successful Laser Treatment: Possible Role of Dermal Stem Cells. ( 27746651 )
2016
2
Comparison of clinical efficacy and complications between Q-switched alexandrite laser and Q-switched Nd:YAG laser on nevus of Ota: a systematic review and meta-analysis. ( 26861980 )
2016
3
A Retrospective Study on the Characteristics of Treating Nevus of Ota by 1064-nm Q-switched Neodymium-doped Yttrium Aluminum Garnet Laser. ( 27293272 )
2016
4
Three cases of symmetrical nevus of Ota and a brief literature review. ( 26889643 )
2016
5
Analysis of 28 Chinese Cases of Bilateral Nevus of Ota and Therapeutic Results With the Q-Switched Alexandrite Laser. ( 26808181 )
2016
6
Primary melanoma of the leptomeninges with bap1 expression-loss in the setting of a nevus of ota: A clinical, morphological and genetic study of 2 cases. ( 26834043 )
2016
7
Phakomatosis pigmentovascularis type IIb: A case with Klippel-TrenA!unay syndrome and extensive dermal melanocytosis as nevus of Ota, nevus of Ito and ectopic Mongolian spots. ( 27374914 )
2016
8
Induction of melasma by 1064-nm Q-switched neodymium:yttrium-aluminum-garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population. ( 26777390 )
2016
9
Nevus of Ota. ( 27734644 )
2016
10
Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations. ( 26701415 )
2016
11
An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota. ( 27699140 )
2016
12
Cerebellar meningeal melanocytoma associated with nevus of Ota: An extremely rare case. ( 26259856 )
2015
13
Giant nevus of Ota. ( 26265645 )
2015
14
A randomized, split-face clinical trial of Q-switched alexandrite laser versus Q-switched Nd:YAG laser in the treatment of bilateral nevus of Ota. ( 25968166 )
2015
15
Spontaneous partial regression of nevus of Ota with the development of vitiligo. ( 26474418 )
2015
16
Treatment of Nevus of Ota With a Picosecond 755-nm Alexandrite Laser. ( 25760558 )
2015
17
Giant Blue Nevus: A New Association to Nevus of Ota. ( 26121271 )
2015
18
The case of a boy with nevus of Ota, extensive Mongolian spot, nevus flammeus, nevus anemicus and cutis marmorata telangiectatica congenita: a unique instance of phacomatosis pigmentovascularis. ( 26312661 )
2015
19
Factors affecting response and laser sessions and complications in Nevus of Ota treated by Q- switched alexandrite laser: A retrospective study. ( 25747257 )
2015
20
Lasers and nevus of Ota: a comprehensive review. ( 26563954 )
2015
21
Intermediate-grade meningeal melanocytoma associated with nevus of Ota: a case report and review of the literature. ( 25933209 )
2015
22
Nevus of Ota/oculodermal melancytosis: a rare report of an oral mucosal lesion involving the hard palate. ( 26682294 )
2015
23
Beneficial effects of early treatment of nevus of Ota with low-fluence 1,064-nm Q-switched Nd:YAG laser. ( 25485806 )
2015
24
Pigment reduction in nevus of Ota following leech therapy. ( 24948864 )
2014
25
Bilateral familial nevus of Ota. ( 25448143 )
2014
26
An unusual case of nevus of Ota combined with nevus spilus. ( 24962014 )
2014
27
Acquired Bilateral Nevus of ota-like Macules with Mucosal Involvement: A New Variant of Hori's Nevus. ( 24891664 )
2014
28
A retrospective analysis of the clinical efficacies of Q-switched Alexandrite and Q-switched Nd:YAG lasers in the treatment of nevus of Ota in Korean patients. ( 24888365 )
2014
29
Animal-type malignant melanoma associated with nevus of Ota in the orbit of a Japanese woman: a case report. ( 24686419 )
2014
30
Centrally located acquired bilateral nevus of ota-like macules: a bizarre pattern. ( 25823087 )
2014
31
BRAF V600E mutation in two distinct meningeal melanocytomas associated with a nevus of Ota. ( 24493731 )
2014
32
Comparison of acquired bilateral nevus of Ota-like macules in men and women. ( 25035355 )
2014
33
A retrospective study on laser treatment of nevus of Ota in Chinese children--a seven-year follow-up. ( 24684590 )
2014
34
Nevus of ota. ( 24986303 )
2014
35
Orbital melanocytoma completely resected with conservative surgery in association with ipsilateral nevus of Ota: Report of a case and review of the literature. ( 24989678 )
2014
36
Malignant melanoma from a nevus of Ota in a pediatric patient with fatal outcome. ( 24034399 )
2013
37
Melanin Index in Assessing the Treatment Efficacy of 1064 nm Q Switched Nd-Yag Laser in Nevus of Ota. ( 24470713 )
2013
38
Orbital malignant melanoma associated with nevus of Ota. ( 23571263 )
2013
39
Assessment of the Response and Improving Outcomes of Nevus of Ota with Q-switched Nd : Yag Laser. ( 24470714 )
2013
40
Treatment of nevus of Ota using low fluence Q-switched Nd:YAG laser. ( 23834371 )
2013
41
Unilateral Nevus of Ota with Bilateral Nevus of Ito and Palatal Lesion: A Case Report with a Proposed Clinical Modification of Tanino's Classification. ( 23918999 )
2013
42
Microsurgical treatment of meningeal malignant melanoma accompanied by nevus of Ota: two case reports and a literature review. ( 24162444 )
2013
43
A new classification of nevus of Ota. ( 24157155 )
2013
44
Unilateral open-angle glaucoma associated with the ipsilateral nevus of ota. ( 23781367 )
2013
45
Pruritic acquired nevus of Ota. ( 24060704 )
2013
46
Nevus of Ota: morphological patterns and distribution in 47 Yemeni cases. ( 21967654 )
2012
47
Are Q-switched lasers for Nevus of Ota really effective in pigmented skin? ( 22421653 )
2012
48
A population-based study of acquired bilateral nevus-of-Ota-like macules in Shanghai, China. ( 20882042 )
2011
49
Nevus of Ota in dark skin--an uncommon but treatable entity. ( 22127621 )
2011
50
Comparing the effectiveness of Q-switched Ruby laser treatment with that of Q-switched Nd:YAG laser for oculodermal melanosis (Nevus of Ota). ( 20619756 )
2011

Variations for Nevus of Ota

Expression for Nevus of Ota

Search GEO for disease gene expression data for Nevus of Ota.

Pathways for Nevus of Ota

Pathways related to Nevus of Ota according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.93 BAP1 TP53
2
Show member pathways
11.91 BRAF TP53
3
Show member pathways
11.86 BRAF TP53
4 11.84 BRAF TP53
5
Show member pathways
11.83 BRAF TP53
6 11.74 BRAF TP53
7
Show member pathways
11.73 BRAF TP53
8
Show member pathways
11.7 BRAF TP53
9 11.66 BRAF TP53
10
Show member pathways
11.64 BRAF TP53
11
Show member pathways
11.58 BRAF TP53
12 11.52 BRAF TP53
13
Show member pathways
11.46 BRAF TP53
14 11.37 BRAF TP53
15 11.28 BRAF TP53
16 11.09 BRAF TP53
17 10.82 BRAF TP53
18 10.09 BRAF TP53

GO Terms for Nevus of Ota

Cellular components related to Nevus of Ota according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 8.8 BAP1 BRAF TP53

Biological processes related to Nevus of Ota according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to drug GO:0035690 8.62 BRAF TP53

Sources for Nevus of Ota

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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