Newborn Respiratory Distress Syndrome malady

Disease Ontology: A syndrome that is characterized as a respiratory disorder that occurs in newborn premature infants and is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.⁶

MalaCards: Newborn Respiratory Distress Syndrome, also known as respiratory distress syndrome, is related to pneumonia and bronchopulmonary dysplasia. An important gene associated with Newborn Respiratory Distress Syndrome is LSR (lipolysis stimulated lipoprotein receptor). The drugs albumin,human and albumin,egg and the compounds nacl and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include lung.

Aliases & Descriptions:

newborn respiratory distress syndrome 6 8 respiratory distress syndrome 6 32 43 hyaline membrane disease 6 32 43 respiratory distress syndrome in the newborn (disorder) 6 idiopathic respiratory distress syndrome, nos 6 idiopathic respiratory distress syndrome irds 6 pulmonary hypoperfusion syndrome of newborn 6 idiopathic respiratory distress of newborn 6 respiratory distress syndrome in newborn 6

respiratory distress syndrome of newborn 6 neonatal respiratory distress syndrome 6 respiratory distress syndrome (& ) 6 respiratory distress syndrome, newborn 43 pulmonary hyaline membrane disease 6 pulmonary hypoperfusion syndrome 43 hmd - hyaline membrane disease 6 emotional distress 43 rds of newborn 6

Diseases related to newborn respiratory distress syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 66)

id	Related Disease	Score	Top Affiliating Genes
1	pneumonia	30.8	TRH, CHKB, SERPINH1, SFTPB, TEF, SFTPA1
2	bronchopulmonary dysplasia	30.4	SFTPA1, SFTPB, SERPINH1
3	hypoxia	26.3	SFTPB, CHKB, TTN, SFTPA1, TRH
4	thyroiditis	26.0	TRH, TEF, SFTPB, TTN, CHKB, SFTPA1
5	pulmonary sclerosing hemangioma	12.9	SFTPA1, SFTPB
6	pulmonary alveolar proteinosis	12.9	SFTPB, SFTPA1
7	sclerosing hemangioma	12.9	SFTPB, SFTPA1
8	meconium aspiration syndrome	12.5	SFTPB, TTN
9	endometritis	12.5	CHKB, SERPINH1
10	limb-girdle muscular dystrophy type 2i	12.4	CHKB, TTN
11	adult respiratory distress syndrome	12.3
12	muscle disorders	12.3	TTN, CHKB
13	myopathy congenital	12.3	CHKB, TTN
14	centronuclear myopathy	12.3	TTN, CHKB
15	pulmonary fibrosis	12.2	SFTPB, SFTPA1, SERPINH1
16	neuromuscular disease	12.2	TTN, CHKB
17	duchenne muscular dystrophy	12.2	CHKB, TTN
18	bronchiolitis	12.1	SFTPA1, CHKB, SFTPB
19	bronchitis	12.0	CHKB, TRH
20	ullrich congenital muscular dystrophy	11.9	TTN, CHKB
21	congenital heart defect	11.6	CHKB, TTN, SFTPB
22	chronic obstructive pulmonary disease	11.5	SFTPB, CHKB, TTN, SFTPA1
23	pulmonary disease	11.4	TTN, CHKB, SFTPB, SFTPA1
24	sepsis	9.7
25	pulmonary edema	8.1
26	septic shock	8.1
27	respiratory distress syndrome, infant	7.7
28	cerebritis	7.6
29	hypertension	7.6
30	pulmonary hypertension	7.6
31	twinning	7.6
32	stiff-person syndrome	7.5
33	chorioamnionitis	6.8
34	surfactant deficiency	6.8
35	asthma	6.7
36	protein s deficiency	6.7
37	avian influenza	6.7
38	patent ductus arteriosus	6.7
39	cerebral malaria	6.7
40	refsum disease	6.7
41	carcinoma	6.7
42	rheumatoid arthritis	6.7
43	cor pulmonale	6.7
44	respiratory failure	6.7
45	esophagitis	6.7
46	severe acute respiratory syndrome	6.7
47	homocysteine	6.7
48	thyroid cancer	6.7
49	hantavirus pulmonary syndrome	6.7
50	trifunctional protein deficiency	6.7

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 albumin,aggregated, albumin,egg, albumin,human, albumin,human inj [va product], albumin,microsphere human serum, nitric oxide, poractant alfa

MalaCards organs/tissues related to newborn respiratory distress syndrome:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Lung -> Alveoli -> Alveolar Epithelial Type 1 Cells	Potential therapeutic candidate, affected by disease
2	Lung -> Alveoli -> Alveolar Epithelial Type 2 Cells	Potential therapeutic candidate, affected by disease
3	Lung -> Pulmonary Capillary Plexus	Potential therapeutic candidate, affected by disease

Articles related to newborn respiratory distress syndrome:

id	Title	Authors	Year	Affiliating Genes
1	Creatine kinase BB activity in the serum and bronchial aspirate of preterm newborns with respiratory distress syndrome (10652804)	SA!nchez Navarro M.R.... Samaniego MuA+oz M.	1999	CHKB

Genes related to newborn respiratory distress syndrome according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	LSR	lipolysis stimulated lipoprotein receptor	11.0	Disorders
2	TEF	thyrotrophic embryonic factor	11.0
3	TRH	thyrotropin-releasing hormone	11.0
4	SFTPB	surfactant protein B	11.0
5	SFTPA1	surfactant protein A1	11.0
6	SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	11.0
7	AP2M1	adaptor-related protein complex 2, mu 1 subunit	11.0
8	CHKB	choline kinase beta	11.0	Publications
9	TTN	titin	11.0
10	C9orf3	chromosome 9 open reading frame 3	11.0	Disorders

Compounds related to newborn respiratory distress syndrome according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	nacl32	9.0	SFTPB, CHKB, TRH
2	ascorbic acid32 18	10.0	SFTPB, SERPINH1, CHKB
3	hydrogen32 18	9.4	TTN, TRH, CHKB, SFTPB
4	polyacrylamide32	8.3	SFTPB, SERPINH1, CHKB, TTN
5	atp32	7.9	TTN, TRH, CHKB, SERPINH1, SFTPB
6	calcium32 9 18 9	10.1	TTN, C9orf3, TRH, CHKB, SFTPB, SFTPA1

Biological processes related to newborn respiratory distress syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	respiratory gaseous exchange	GO:007585	9.7	SFTPA1, SFTPB