MCID: NWB001
MIFTS: 57

Newborn Respiratory Distress Syndrome

Categories: Fetal diseases, Respiratory diseases

Aliases & Classifications for Newborn Respiratory Distress Syndrome

MalaCards integrated aliases for Newborn Respiratory Distress Syndrome:

Name: Newborn Respiratory Distress Syndrome 37 12 14
Hyaline Membrane Disease 12 51 41 69
Respiratory Distress Syndrome 69 59
Pulmonary Hypoperfusion Syndrome of Newborn 12
Respiratory Distress Syndrome of Newborn 12
Neonatal Respiratory Distress Syndrome 12
Respiratory Distress Syndrome, Newborn 69
Respiratory Distress Syndrome, Adult 69
Pulmonary Hyaline Membrane Disease 12
Hmd - Hyaline Membrane Disease 12
Neonatal Respiratory Distress 28
Respiratory Distress 28

Classifications:



External Ids:

Disease Ontology 12 DOID:12716
ICD10 32 P22.0
MeSH 41 D006819

Summaries for Newborn Respiratory Distress Syndrome

PubMed Health : 59
About respiratory distress syndrome: Respiratory distress syndrome (RDS) is a breathing disorder that affects newborns. RDS rarely occurs in full-term infants. The disorder is more common in premature infants born about 6 weeks or more before their due dates.RDS is more common in premature infants because their lungs aren't able to make enough surfactant (sur-FAK-tant). Surfactant is a liquid that coats the inside of the lungs. It helps keep them open so that infants can breathe in air once they're born.Without enough surfactant, the lungs collapse and the infant has to work hard to breathe. He or she might not be able to breathe in enough oxygen to support the body's organs. The lack of oxygen can damage the baby's brain and other organs if proper treatment isn't given.Most babies who develop RDS show signs of breathing problems and a lack of oxygen at birth or within the first few hours that follow.

MalaCards based summary : Newborn Respiratory Distress Syndrome, also known as hyaline membrane disease, is related to respiratory distress syndrome in premature infants and choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction, and has symptoms including labored breathing, respiratory distress and hoarseness. An important gene associated with Newborn Respiratory Distress Syndrome is SFTPB (Surfactant Protein B), and among its related pathways/superpathways are Bacterial infections in CF airways and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Infasurf and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include Lung and Lung, and related phenotypes are mortality/aging and neoplasm

Disease Ontology : 12 A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

Related Diseases for Newborn Respiratory Distress Syndrome

Diseases related to Newborn Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome in premature infants 30.2 ABCA3 SFTPB SFTPC
2 choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction 11.8
3 paraquat lung 10.5 SCGB1A1 SFTPB
4 toxic pneumonitis 10.5 SCGB1A1 SFTPB
5 tracheal agenesis 10.4 SFTPB SFTPD
6 hemangioma of lung 10.4 NKX2-1 SFTPB
7 pulmonary sclerosing hemangioma 10.4 NKX2-1 SFTPB
8 sclerosing hemangioma 10.3 NKX2-1 SFTPB
9 meconium aspiration syndrome 10.3 CXCL8 SCGB1A1 SFTPB
10 recurrent corneal erosion 10.3 CXCL8 IL1B
11 bagassosis 10.2 CXCL8 IL1B
12 diaphragm disease 10.2 SFTPB SFTPC
13 peptic esophagitis 10.2 CXCL8 IL1B
14 acute chest syndrome 10.2 CXCL8 PLA2G2A
15 felty syndrome 10.2 CXCL8 ELANE
16 funisitis 10.2 CXCL8 IL1B
17 opisthorchiasis 10.2 CXCL8 IL1B
18 cardiac rupture 10.2 CXCL8 ELANE
19 lung benign neoplasm 10.2 NKX2-1 SCGB1A1 SFTPC
20 cyclic neutropenia 10.2 CXCL8 ELANE
21 crohn's colitis 10.2 CXCL8 IL1B
22 diaphragmatic hernia, congenital 10.2 NKX2-1 SFTPB SFTPC
23 capillary leak syndrome 10.2 CXCL8 ELANE
24 pulmonary immaturity 10.2 SFTPB SFTPC SFTPD
25 pulmonary alveolar proteinosis 10.2 SFTPB SFTPC SFTPD
26 dental pulp disease 10.2 CXCL8 IL1B
27 status asthmaticus 10.2 CXCL8 ELANE
28 vaginal disease 10.2 CXCL8 IL1B
29 vaginitis 10.2 CXCL8 IL1B
30 endometrial disease 10.2 CXCL8 IL1B
31 eales disease 10.2 IL1B TF
32 periodontosis 10.2 CXCL8 ELANE
33 aseptic meningitis 10.1 CXCL8 IL1B
34 pulpitis 10.1 CXCL8 IL1B
35 pharyngitis 10.1 CXCL8 IL1B
36 wells syndrome 10.1 CXCL8 IL1B
37 pneumoconiosis 10.1 CXCL8 IL1B SCGB1A1
38 desquamative interstitial pneumonia 10.1 ABCA3 SFTPC
39 middle ear disease 10.1 CXCL8 IL1B
40 haemophilus influenzae 10.1 CXCL8 IL1B TF
41 trypanosomiasis 10.0 CXCL8 IL1B TF
42 lung cancer susceptibility 3 10.0 NKX2-1 SCGB1A1 SFTPB SFTPC
43 sarcoidosis 1 10.0 IL1B SCGB1A1 SFTPD
44 extrinsic allergic alveolitis 10.0 CXCL8 IL1B SFTPD
45 pulmonary fibrosis 10.0 IL1B SFTPC SFTPD
46 diffuse pulmonary fibrosis 10.0 ABCA3 SFTPC
47 gingival disease 10.0 ELANE IL1B
48 viral encephalitis 9.9 CXCL8 IL1B
49 acute pancreatitis 9.9 CXCL8 ELANE PLA2G2A
50 neonatal respiratory failure 9.9 ABCA3 SFTPB SFTPC

Graphical network of the top 20 diseases related to Newborn Respiratory Distress Syndrome:



Diseases related to Newborn Respiratory Distress Syndrome

Symptoms & Phenotypes for Newborn Respiratory Distress Syndrome

UMLS symptoms related to Newborn Respiratory Distress Syndrome:


labored breathing, respiratory distress, hoarseness, hemoptysis, dyspnea, coughing, cheyne-stokes respiration, apnea

MGI Mouse Phenotypes related to Newborn Respiratory Distress Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.81 ABCA3 ELANE IL1B NKX2-1 SCGB1A1 SFTPB
2 neoplasm MP:0002006 9.35 ELANE IL1B NKX2-1 SCGB1A1 SFTPC
3 respiratory system MP:0005388 9.1 NKX2-1 SCGB1A1 SFTPB SFTPC SFTPD ABCA3

Drugs & Therapeutics for Newborn Respiratory Distress Syndrome

PubMedHealth treatment related to Newborn Respiratory Distress Syndrome: 59

Treatment for respiratory distress syndrome (RDS) usually begins as soon as an infant is born, sometimes in the delivery room.Most infants who show signs of RDS are quickly moved to a neonatal intensive care unit (NICU). There they receive around-the-clock treatment from health care professionals who specialize in treating premature infants.The most important treatments for RDS are:Surfactant replacement therapy.Breathing support from a ventilator or nasal continuous positive airway pressure (NCPAP) machine. These machines help premature infants breathe better. Oxygen therapy.

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Infasurf 17 CALFACTANT ONY July 1998

Drugs for Newborn Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 393)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 3 59467-70-8 4192
2
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
3
Remifentanil Approved Phase 4 132875-61-7 60815
4 Cisatracurium Approved, Experimental Phase 4,Phase 3 96946-41-7
5
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
6
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 657311 5754
7 Racepinephrine Approved Phase 4,Phase 2 329-65-7
8 Beractant Approved Phase 4,Phase 2,Phase 3,Phase 1 108778-82-1
9
Budesonide Approved Phase 4,Phase 2 51333-22-3 5281004 63006
10 Poractant alfa Approved Phase 4,Phase 2,Phase 3 129069-19-8
11
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
12
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
13
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1 103-90-2 1983
14
Clonidine Approved Phase 4 4205-90-7 2803
15 Nefopam Approved, Investigational Phase 4 13669-70-0
16
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
17
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
18
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
19
Carbon monoxide Approved, Investigational Phase 4,Phase 1 630-08-0 281
20
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
21
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
22
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
23
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
24
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2 7440-66-6 32051 23994
25
Povidone-iodine Approved Phase 4,Phase 3,Phase 2 25655-41-8
26
Metformin Approved Phase 4 657-24-9 4091 14219
27
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
28
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
29
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
30
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 57-83-0 5994
31
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
32
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 76631-46-4, 113775-47-6 5311068 56032 68602
33
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
34
Misoprostol Approved Phase 4 59122-46-2 5282381
35 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
36
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 56-40-6 750
37
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
38
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
39
B-Carotene Approved, Nutraceutical Phase 4 7235-40-7 5280489
40
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3 67-97-0 10883523 5280795 6221
41
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
42
Butyric Acid Experimental, Investigational Phase 4,Phase 3,Phase 2 107-92-6 264
43 Sivelestat Investigational Phase 4,Phase 1,Phase 2 127373-66-4
44 Adjuvants, Anesthesia Phase 4,Phase 3
45 Anesthetics Phase 4,Phase 3,Early Phase 1
46 Anesthetics, General Phase 4,Phase 3
47 Anesthetics, Intravenous Phase 4,Phase 3
48 Anti-Anxiety Agents Phase 4,Phase 3
49 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
50 GABA Agents Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 1013)

# Name Status NCT ID Phase Drugs
1 Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS) Unknown status NCT00797160 Phase 4 propofol
2 Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway Unknown status NCT01173237 Phase 4
3 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
4 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
5 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
6 Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
7 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
8 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
9 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
10 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
11 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
12 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
13 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
14 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
15 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
16 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
17 Corticosteroid Mediates Acute Respiratory Distress Syndrome Completed NCT02819453 Phase 4 Methylprednisolone
18 Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome Completed NCT00391105 Phase 4 Remifentanil
19 Standard Treatment Compliance of Participants, Effectiveness and Prognosis in Acute Respiratory Distress Syndrome Completed NCT02178982 Phase 4
20 Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide Completed NCT01923844 Phase 4 exogenous surfactant
21 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
22 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation Completed NCT01042600 Phase 4
23 Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study) Completed NCT02166853 Phase 4 sevoflurane;midazolam
24 Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
25 Caesarean and Corticotherapy Completed NCT00446953 Phase 4 betamethasone
26 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
27 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
28 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
29 INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery Completed NCT01020409 Phase 4
30 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
31 Vaginal Progesterone for Prevention of Preterm Labor in Asymptomatic Twin Pregnancies With Sonographic Short Cervix Completed NCT02338830 Phase 4 Progesterone
32 Steroids in Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
33 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
34 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
35 Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure Completed NCT00686257 Phase 4
36 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
37 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
38 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
39 Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study) Completed NCT01282996 Phase 4
40 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
41 Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome Recruiting NCT01731795 Phase 4 Dexamethasone
42 Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome Recruiting NCT02164734 Phase 4 remifentanil
43 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT01763853 Phase 4 4% albumin
44 Effect of Antenatal Steroid on Pulmonary Artery Blood Flow Recruiting NCT02978976 Phase 4 Betamethasone;saline
45 The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
46 Vaginal Progesterone Versus Cervical Cerclage for Pregnant Women With Short Cervix and History of PTL and/or MTM Recruiting NCT02673359 Phase 4 Progesterone
47 Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation Recruiting NCT02958150 Phase 4 Dexmedetomidine
48 Early Non-invasive Ventilation Outside the Intensive Care Unit Recruiting NCT01572337 Phase 4
49 Handling Oxygenation Targets in the Intensive Care Unit Recruiting NCT03174002 Phase 4 Oxygen;Oxygen
50 Cervical Cerclage for Preventing Spontaneous Preterm Birth in Singleton Pregnancies Without Prior Spontaneous Preterm Birth and With Short Transvaginal Ultrasound Cervical Length Recruiting NCT02746900 Phase 4

Search NIH Clinical Center for Newborn Respiratory Distress Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: hyaline membrane disease

Genetic Tests for Newborn Respiratory Distress Syndrome

Genetic tests related to Newborn Respiratory Distress Syndrome:

# Genetic test Affiliating Genes
1 Respiratory Distress 28
2 Neonatal Respiratory Distress 28

Anatomical Context for Newborn Respiratory Distress Syndrome

MalaCards organs/tissues related to Newborn Respiratory Distress Syndrome:

38
Lung, Brain, Testes, Liver, Fetal Lung, Cervix, Heart
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Newborn Respiratory Distress Syndrome:
# Tissue Anatomical CompartmentCell Relevance
1 Lung Alveoli Alveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 Lung Alveoli Alveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 Lung Pulmonary Capillary Plexus Affected by disease

Publications for Newborn Respiratory Distress Syndrome

Articles related to Newborn Respiratory Distress Syndrome:

(show all 22)
# Title Authors Year
1
[Expression of nuclear factor-kappaB and its inhibitor in alveolar macrophages of patients with neonatal hyaline membrane disease]. ( 17083791 )
2006
2
Nuclear factor kappaB activation in pulmonary leukocytes from infants with hyaline membrane disease: associations with chorioamnionitis and Ureaplasma urealyticum colonization. ( 15746262 )
2005
3
Deficient Na+ channel expression in newborn respiratory distress syndrome. ( 15029631 )
2004
4
Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD). ( 12005259 )
2001
5
Interleukin-8 expression by fetal and neonatal pulmonary cells in hyaline membrane disease and amniotic infection. ( 10960493 )
2000
6
Differential regulation of IL-8 by IL-1beta and TNFalpha in hyaline membrane disease. ( 9475356 )
1998
7
Changes in anti-oxidant enzymes and lipid peroxidation in hyaline membrane disease. ( 10773913 )
1998
8
Undetectable interleukin (IL)-10 and persistent IL-8 expression early in hyaline membrane disease: a possible developmental basis for the predisposition to chronic lung inflammation in preterm newborns. ( 8725256 )
1996
9
Immunohistochemical study of copper-zinc and manganese superoxide dismutases in the lungs of human fetuses and newborn infants: developmental profile and alterations in hyaline membrane disease and bronchopulmonary dysplasia. ( 8236811 )
1993
10
Air embolism and pulmonary interstitial emphysema in a preterm infant with hyaline membrane disease. ( 1771121 )
1991
11
High viscosity of newborn extracellular matrix is the etiology of erythema toxicum neonatorum: neonatal jaundice?: hyaline membrane disease? ( 2255269 )
1990
12
Lipid peroxidation and expression of copper-zinc and manganese superoxide dismutase in lungs of premature infants with hyaline membrane disease and bronchopulmonary dysplasia. ( 2230537 )
1990
13
Pulmonary vascular damage and the development of cor pulmonale following hyaline membrane disease. ( 2148977 )
1990
14
Pulmonary interstitial emphysema in the premature baboon with hyaline membrane disease. ( 6373147 )
1984
15
Prediction of the newborn respiratory distress syndrome by means of the hydrogen peroxide hemolysis test. ( 6895985 )
1982
16
Nonoperative resolution of prolonged localized intrapulmonary interstitial emphysema associated with hyaline membrane disease. ( 333073 )
1977
17
The PaO2 response to changes in end expiratory pressure in the newborn respiratory distress syndrome. ( 332446 )
1977
18
Air embolus following pulmonary interstitial emphysema in hyaline membrane disease. ( 944116 )
1976
19
Pulmonary interstitial emphysema with gas embolism in hyaline membrane disease. ( 4579214 )
1973
20
Changes of venous admixture with inspired oxygen in hyaline membrane disease and foetal aspiration pneumonia. ( 4736055 )
1973
21
Intrapulmonary interstitial emphysema: a complication of hyaline membrane disease. ( 5489682 )
1970
22
Severe interstitial emphysema, pneumomediastinum, and pneumothorax: uncommon complications of hyaline membrane disease. ( 13700031 )
1961

Variations for Newborn Respiratory Distress Syndrome

ClinVar genetic disease variations for Newborn Respiratory Distress Syndrome:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BRAF NM_004333.4(BRAF): c.1502A> G (p.Glu501Gly) single nucleotide variant Pathogenic/Likely pathogenic rs180177039 GRCh37 Chromosome 7, 140477806: 140477806

Expression for Newborn Respiratory Distress Syndrome

Search GEO for disease gene expression data for Newborn Respiratory Distress Syndrome.

Pathways for Newborn Respiratory Distress Syndrome

Pathways related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.8 CXCL8 IL1B SFTPD
2 11.76 CXCL8 IL1B TF
3 11.58 CXCL8 IL1B PLA2G2A
4
Show member pathways
11.42 SFTPB SFTPC SFTPD
5 11.13 CXCL8 IL1B SFTPC
6
Show member pathways
10.56 ABCA3 SFTPB SFTPC SFTPD
7
Show member pathways
10.53 SFTPB SFTPC SFTPD

GO Terms for Newborn Respiratory Distress Syndrome

Cellular components related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 CXCL8 ELANE IL1B PLA2G2A SCGB1A1 SFTPB
2 clathrin-coated endocytic vesicle GO:0045334 9.5 SFTPB SFTPC SFTPD
3 secretory granule GO:0030141 9.46 ELANE IL1B PLA2G2A SCGB1A1
4 multivesicular body lumen GO:0097486 9.4 SFTPB SFTPC
5 alveolar lamellar body GO:0097208 9.37 ABCA3 SFTPB
6 extracellular space GO:0005615 9.32 ABCA3 CXCL8 ELANE IL1B PLA2G2A SCGB1A1
7 lamellar body GO:0042599 9.13 SFTPB SFTPC SFTPD

Biological processes related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.33 ELANE IL1B SCGB1A1
2 negative regulation of T cell proliferation GO:0042130 9.32 SCGB1A1 SFTPD
3 positive regulation of phagocytosis GO:0050766 9.26 IL1B SFTPD
4 respiratory gaseous exchange GO:0007585 9.13 SFTPB SFTPC SFTPD
5 cellular protein metabolic process GO:0044267 9.02 ABCA3 SFTPB SFTPC SFTPD TF

Sources for Newborn Respiratory Distress Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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