MCID: NWB001
MIFTS: 46

Newborn Respiratory Distress Syndrome

Categories: Fetal diseases, Respiratory diseases

Aliases & Classifications for Newborn Respiratory Distress Syndrome

MalaCards integrated aliases for Newborn Respiratory Distress Syndrome:

Name: Newborn Respiratory Distress Syndrome 38 12 14
Hyaline Membrane Disease 12 52 42 69
Pulmonary Hypoperfusion Syndrome of Newborn 12
Respiratory Distress Syndrome of Newborn 12
Neonatal Respiratory Distress Syndrome 12
Respiratory Distress Syndrome, Newborn 69
Pulmonary Hyaline Membrane Disease 12
Hmd - Hyaline Membrane Disease 12
Neonatal Respiratory Distress 29
Respiratory Distress Syndrome 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12716
ICD10 33 P22.0
MeSH 42 D006819
UMLS 69 C0020192

Summaries for Newborn Respiratory Distress Syndrome

Disease Ontology : 12 A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

MalaCards based summary : Newborn Respiratory Distress Syndrome, also known as hyaline membrane disease, is related to choreoathetosis, hypothyroidism, and neonatal respiratory distress and esophagus adenocarcinoma, and has symptoms including cheyne-stokes respiration, coughing and dyspnea. An important gene associated with Newborn Respiratory Distress Syndrome is SFTPB (Surfactant Protein B), and among its related pathways/superpathways are Diseases of metabolism and Lung fibrosis. The drugs Infasurf and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include Lung and Lung, and related phenotypes are cardiovascular system and mortality/aging

Related Diseases for Newborn Respiratory Distress Syndrome

Graphical network of the top 20 diseases related to Newborn Respiratory Distress Syndrome:



Diseases related to Newborn Respiratory Distress Syndrome

Symptoms & Phenotypes for Newborn Respiratory Distress Syndrome

UMLS symptoms related to Newborn Respiratory Distress Syndrome:


cheyne-stokes respiration, coughing, dyspnea, hemoptysis, hoarseness, respiratory distress

MGI Mouse Phenotypes related to Newborn Respiratory Distress Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 ABCA3 NKX2-1 PLG SERPINH1 SFTPC TTN
2 mortality/aging MP:0010768 9.56 TTN ABCA3 COQ4 NKX2-1 PLG SERPINH1
3 respiratory system MP:0005388 9.1 ABCA3 NKX2-1 PLG SERPINH1 SFTPB SFTPC

Drugs & Therapeutics for Newborn Respiratory Distress Syndrome

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Infasurf 17 CALFACTANT ONY July 1998

Drugs for Newborn Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 378)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 3 59467-70-8 4192
2
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
5
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 5754 657311
6 Racepinephrine Approved Phase 4,Phase 2
7 Beractant Approved Phase 4,Phase 2,Phase 3,Phase 1 108778-82-1
8 Poractant alfa Approved Phase 4,Phase 2,Phase 3 129069-19-8
9
Budesonide Approved Phase 4,Phase 2 51333-22-3 63006 5281004
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
12
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1 103-90-2 1983
13
Clonidine Approved Phase 4 4205-90-7 2803
14
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
15
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
16
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
17
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
18
Carbon monoxide Approved Phase 4,Phase 1 630-08-0 281
19
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
20
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
21
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
22 Povidone-iodine Approved Phase 4,Phase 3,Phase 2 25655-41-8
23
Metformin Approved Phase 4 657-24-9 14219 4091
24
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
25
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
26
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
27
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 57-83-0 5994
28
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
29
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
30
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
31
Misoprostol Approved Phase 4 59122-46-2 5282381
32 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
33
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 56-40-6 750
34 Cisatracurium Experimental Phase 4,Phase 3 96946-41-7
35
Butyric Acid Experimental Phase 4,Phase 3,Phase 2 107-92-6 264
36 Nefopam Investigational Phase 4 13669-70-0
37 Sivelestat Investigational Phase 4,Phase 1,Phase 2 127373-66-4
38 Adjuvants, Anesthesia Phase 4,Phase 3
39 Anesthetics Phase 4,Phase 3,Early Phase 1
40 Anesthetics, General Phase 4,Phase 3
41 Anesthetics, Intravenous Phase 4,Phase 3
42 Anti-Anxiety Agents Phase 4,Phase 3
43 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
44 GABA Agents Phase 4,Phase 3
45 GABA Modulators Phase 4,Phase 3
46 Hypnotics and Sedatives Phase 4,Phase 3,Phase 1,Phase 2
47 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Psychotropic Drugs Phase 4,Phase 3
49 Pulmonary Surfactants Phase 4,Phase 3,Phase 2,Phase 1
50 Tranquilizing Agents Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 969)

id Name Status NCT ID Phase Drugs
1 Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS) Unknown status NCT00797160 Phase 4 propofol
2 Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway Unknown status NCT01173237 Phase 4
3 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
4 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
5 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
6 Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
7 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
8 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
9 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
10 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
11 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
12 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
13 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
14 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
15 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
16 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
17 Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome Completed NCT00391105 Phase 4 Remifentanil
18 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation Completed NCT01042600 Phase 4
19 Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide Completed NCT01923844 Phase 4 exogenous surfactant
20 Standard Treatment Compliance of Participants, Effectiveness and Prognosis in Acute Respiratory Distress Syndrome Completed NCT02178982 Phase 4
21 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
22 Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
23 Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study) Completed NCT02166853 Phase 4 sevoflurane;midazolam
24 Caesarean and Corticotherapy Completed NCT00446953 Phase 4 betamethasone
25 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
26 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
27 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
28 INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery Completed NCT01020409 Phase 4
29 Vaginal Progesterone for Prevention of Preterm Labor in Asymptomatic Twin Pregnancies With Sonographic Short Cervix Completed NCT02338830 Phase 4 Progesterone
30 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
31 Steroids in Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
32 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
33 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
34 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
35 Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure Completed NCT00686257 Phase 4
36 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
37 Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study) Completed NCT01282996 Phase 4
38 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
39 Corticosteroid Mediates Acute Respiratory Distress Syndrome Recruiting NCT02819453 Phase 4 Dexamethasone
40 Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome Recruiting NCT02164734 Phase 4 remifentanil
41 Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome Recruiting NCT01731795 Phase 4 Dexamethasone
42 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT01763853 Phase 4 4% albumin
43 Effect of Antenatal Steroid on Pulmonary Artery Blood Flow Recruiting NCT02978976 Phase 4 Betamethasone;saline
44 Vaginal Progesterone Versus Cervical Cerclage for Pregnant Women With Short Cervix and History of PTL and/or MTM Recruiting NCT02673359 Phase 4 Progesterone
45 Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation Recruiting NCT02958150 Phase 4 Dexmedetomidine
46 Early Non-invasive Ventilation Outside the Intensive Care Unit Recruiting NCT01572337 Phase 4
47 Handling Oxygenation Targets in the Intensive Care Unit Recruiting NCT03174002 Phase 4 Oxygen;Oxygen
48 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Recruiting NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
49 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part I Recruiting NCT01604317 Phase 4
50 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part II Recruiting NCT01604421 Phase 4

Search NIH Clinical Center for Newborn Respiratory Distress Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hyaline membrane disease

Genetic Tests for Newborn Respiratory Distress Syndrome

Genetic tests related to Newborn Respiratory Distress Syndrome:

id Genetic test Affiliating Genes
1 Neonatal Respiratory Distress 29

Anatomical Context for Newborn Respiratory Distress Syndrome

MalaCards organs/tissues related to Newborn Respiratory Distress Syndrome:

39
Lung, Brain, Testes, Fetal Lung, Cervix, Liver, Heart
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Newborn Respiratory Distress Syndrome:
id Tissue Anatomical CompartmentCell Relevance
1 Lung Alveoli Alveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 Lung Alveoli Alveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 Lung Pulmonary Capillary Plexus Affected by disease

Publications for Newborn Respiratory Distress Syndrome

Articles related to Newborn Respiratory Distress Syndrome:

id Title Authors Year
1
Deficient Na+ channel expression in newborn respiratory distress syndrome. ( 15029631 )
2004
2
Prediction of the newborn respiratory distress syndrome by means of the hydrogen peroxide hemolysis test. ( 6895985 )
1982
3
The PaO2 response to changes in end expiratory pressure in the newborn respiratory distress syndrome. ( 332446 )
1977

Variations for Newborn Respiratory Distress Syndrome

ClinVar genetic disease variations for Newborn Respiratory Distress Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 BRAF NM_004333.4(BRAF): c.1502A> G (p.Glu501Gly) single nucleotide variant Pathogenic/Likely pathogenic rs180177039 GRCh37 Chromosome 7, 140477806: 140477806

Expression for Newborn Respiratory Distress Syndrome

Search GEO for disease gene expression data for Newborn Respiratory Distress Syndrome.

GO Terms for Newborn Respiratory Distress Syndrome

Cellular components related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ABCA3 PLG SERPINH1 SFTPA2 SFTPB SFTPC
2 multivesicular body lumen GO:0097486 9.26 SFTPB SFTPC
3 alveolar lamellar body GO:0097208 9.16 ABCA3 SFTPB
4 clathrin-coated endocytic vesicle GO:0045334 9.13 SFTPA2 SFTPB SFTPC
5 lamellar body GO:0042599 8.8 SFTPA2 SFTPB SFTPC

Biological processes related to Newborn Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 respiratory gaseous exchange GO:0007585 9.13 SFTPA2 SFTPB SFTPC
2 cellular protein metabolic process GO:0044267 9.02 ABCA3 PLG SFTPA2 SFTPB SFTPC

Sources for Newborn Respiratory Distress Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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