MCID: NWB001
MIFTS: 38

Newborn Respiratory Distress Syndrome malady

Fetal diseases, Respiratory diseases categories
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Summaries for Newborn Respiratory Distress Syndrome

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Disease Ontology:8 A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

MalaCards based summary: Newborn Respiratory Distress Syndrome, also known as hyaline membrane disease, is related to interstitial emphysema and funisitis. An important gene associated with Newborn Respiratory Distress Syndrome is SFTPA1 (surfactant protein A1). The drugs nitric oxide and beractant and the compounds proline and polyacrylamide have been mentioned in the context of this disorder. Affiliated tissues include lung and testes.

Description from OMIM:46 267450

Aliases & Classifications for Newborn Respiratory Distress Syndrome

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Newborn Respiratory Distress Syndrome, Aliases & Descriptions:

Name: Newborn Respiratory Distress Syndrome 30 8 10
Hyaline Membrane Disease 8 44 62
Pulmonary Hypoperfusion Syndrome of Newborn 8 62
Respiratory Distress Syndrome of Newborn 8 62
 
Pulmonary Hyaline Membrane Disease 8 62
Hmd - Hyaline Membrane Disease 8 62
Neonatal Respiratory Distress Syndrome 8
Respiratory Distress Syndrome, Newborn 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:12716
OMIM46 267450
MeSH34 D006819
ICD1025 P22, P22.0

Related Diseases for Newborn Respiratory Distress Syndrome

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Graphical network of the top 20 diseases related to Newborn Respiratory Distress Syndrome:



Diseases related to newborn respiratory distress syndrome

Symptoms for Newborn Respiratory Distress Syndrome

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Clinical features from OMIM:

267450

Drugs & Therapeutics for Newborn Respiratory Distress Syndrome

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Drug clinical trials:

Search ClinicalTrials for Newborn Respiratory Distress Syndrome

Search NIH Clinical Center for Newborn Respiratory Distress Syndrome

Inferred drug relations via UMLS62/NDF-RT40:

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Genetic Tests for Newborn Respiratory Distress Syndrome

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Anatomical Context for Newborn Respiratory Distress Syndrome

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MalaCards organs/tissues related to Newborn Respiratory Distress Syndrome:

32
Lung, Testes

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Newborn Respiratory Distress Syndrome:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Newborn Respiratory Distress Syndrome or affiliated genes

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Publications for Newborn Respiratory Distress Syndrome

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Articles related to Newborn Respiratory Distress Syndrome:

idTitleAuthorsYear
1
Deficient Na+ channel expression in newborn respiratory distress syndrome. (15029631)
2004
2
Prediction of the newborn respiratory distress syndrome by means of the hydrogen peroxide hemolysis test. (6895985)
1982
3
The PaO2 response to changes in end expiratory pressure in the newborn respiratory distress syndrome. (332446)
1977

Variations for Newborn Respiratory Distress Syndrome

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Expression for genes affiliated with Newborn Respiratory Distress Syndrome

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Expression patterns in normal tissues for genes affiliated with Newborn Respiratory Distress Syndrome

Search GEO for disease gene expression data for Newborn Respiratory Distress Syndrome.

Pathways for genes affiliated with Newborn Respiratory Distress Syndrome

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Compounds for genes affiliated with Newborn Respiratory Distress Syndrome

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Sources:
44Novoseek, 28IUPHAR
See all sources

Compounds related to Newborn Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1proline449.3SERPINH1, TTN
2polyacrylamide449.0SERPINH1, TTN
3atp44 289.4CHPT1, SERPINH1, TTN

GO Terms for genes affiliated with Newborn Respiratory Distress Syndrome

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Products for genes affiliated with Newborn Respiratory Distress Syndrome

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  • Antibodies
  • Proteins
  • Lysates

Sources for Newborn Respiratory Distress Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet