MCID: NWB001
MIFTS: 48

Newborn Respiratory Distress Syndrome malady

Fetal diseases category

Summaries for Newborn Respiratory Distress Syndrome

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 A syndrome that is characterized as a respiratory disorder that occurs in newborn premature infants and is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

MalaCards: Newborn Respiratory Distress Syndrome, also known as respiratory distress syndrome, is related to respiratory failure and thyroiditis. An important gene associated with Newborn Respiratory Distress Syndrome is CHKB (choline kinase beta), and among its related pathways is Synthesis of PE. The drugs nitric oxide and beractant and the compounds ethanolamine and phosphorylcholine have been mentioned in the context of this disorder. Affiliated tissues include lung and testes.

Description from OMIM:46 267450

Aliases & Classifications for Newborn Respiratory Distress Syndrome

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8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

newborn respiratory distress syndrome 8 10
respiratory distress syndrome 8 22 44 60
hyaline membrane disease 8 44 60
idiopathic respiratory distress syndrome irds 8
idiopathic respiratory distress syndrome, nos 8
respiratory distress syndrome in the newborn 8
pulmonary hypoperfusion syndrome of newborn 8
idiopathic respiratory distress of newborn 8
respiratory distress syndrome in newborn 8
respiratory distress syndrome of newborn 8
respiratory distress syndrome, newborn 60
neonatal respiratory distress syndrome 8
pulmonary hyaline membrane disease 8
hmd - hyaline membrane disease 8
rds of newborn 8


External Ids:

Disease Ontology8 DOID:12716
MeSH34 D006819
OMIM46 267450
ICD1025 P22, P22.0

Related Diseases for Newborn Respiratory Distress Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Newborn Respiratory Distress Syndrome:



Diseases related to newborn respiratory distress syndrome

Clinical Features for Newborn Respiratory Distress Syndrome

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46OMIM
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Clinical features from OMIM:

267450

Drugs & Therapeutics for Newborn Respiratory Distress Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Newborn Respiratory Distress Syndrome

Drug clinical trials:

Search ClinicalTrials for Newborn Respiratory Distress Syndrome

Search NIH Clinical Center for Newborn Respiratory Distress Syndrome

Search CenterWatch for Newborn Respiratory Distress Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Newborn Respiratory Distress Syndrome

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22GTR
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Genetic tests related to Newborn Respiratory Distress Syndrome:

id Genetic test Affiliating Genes
1 Respiratory Distress22

Anatomical Context for Newborn Respiratory Distress Syndrome

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Newborn Respiratory Distress Syndrome:

32
Lung, Testes

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Newborn Respiratory Distress Syndrome:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Newborn Respiratory Distress Syndrome or affiliated genes

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Publications for Newborn Respiratory Distress Syndrome

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50PubMed
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Articles related to Newborn Respiratory Distress Syndrome:

(show all 17)
idTitleAuthorsYear
1
Detection of genetic defect within ABCA3 from newborns with respiratory distress syndrome]. (22455634)
2012
2
Cleidocranial dysplasia (CCD) causing respiratory distress syndrome in a newborn infant. A case report. (22470720)
2010
3
Comparison of surfactant protein B polymorphisms of healthy term newborns with preterm newborns having respiratory distress syndrome. (17581675)
2007
4
Kartagener syndrome: an unusual cause of respiratory distress in the newborn. (17111736)
2006
5
Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: beneficial effects of melatonin. (15168319)
2004
6
Deficient Na+ channel expression in newborn respiratory distress syndrome. (15029631)
2004
7
Superoxide dismutase and catalase activity in tracheobronchial secretions after surfactant treatment of newborn infants with respiratory distress syndrome]. (10596413)
1999
8
Creatine kinase BB activity in the serum and bronchial aspirate of preterm newborns with respiratory distress syndrome]. (10652804)
1999
9
Influence of neonatal idiopathic respiratory distress syndrome on serum enzyme activities in premature healthy and asphyxiated newborns. (8865977)
1996
10
Vasopressin, atrial natriuretic factor and renal water homeostasis in premature newborn infants with respiratory distress syndrome. (8537861)
1995
11
Respiratory distress in a newborn with primary ciliary dyskinesia, situs inversus and Turner syndrome. (8084322)
1994
12
Adult respiratory distress syndrome in newborns: 5 cases. (8052790)
1993
13
Adult respiratory distress syndrome in newborn infants. (8365228)
1993
14
Prediction of the newborn respiratory distress syndrome by means of the hydrogen peroxide hemolysis test. (6895985)
1982
15
The PaO2 response to changes in end expiratory pressure in the newborn respiratory distress syndrome. (332446)
1977
16
Diagnosis oligohydramnios-related pulmonary hypoplasia (Potter syndrome): value of portable voiding cystourethrography in newborns with respiratory distress. (928707)
1977
17
Two cases of rare causes of respiratory distress in the newborn. 1. Congenital pulmonary lymphangiectasis. 2. Wilson-Mikity syndrome. (5644902)
1968

Genetic Variations for Newborn Respiratory Distress Syndrome

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Expression for genes affiliated with Newborn Respiratory Distress Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Newborn Respiratory Distress Syndrome

Search GEO for disease gene expression data for Newborn Respiratory Distress Syndrome.

Pathways for genes affiliated with Newborn Respiratory Distress Syndrome

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53Reactome
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Pathways related to Newborn Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8CHKB, CHPT1

Compounds for genes affiliated with Newborn Respiratory Distress Syndrome

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Newborn Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ethanolamine44 11 2411.9CHKB, CHPT1
2phosphorylcholine44 2410.9CHPT1, CHKB
3ascorbic acid44 2410.6SERPINH1, CHKB, SFTPB
4polyacrylamide449.4SFTPB, CHKB, TTN, SERPINH1
5nacl449.3TRH, CHKB, SFTPB
6hydrogen44 2410.1TTN, TRH, CHKB, SFTPB
7lipid448.1SFTPB, LSR, CHPT1, TRH, ABCA3
8atp44 289.0SERPINH1, TTN, ABCA3, TRH, CHKB, CHPT1
9calcium44 49 11 2410.8SFTPA1, SFTPB, C9orf3, CHKB, TRH, TTN

GO Terms for genes affiliated with Newborn Respiratory Distress Syndrome

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16Gene Ontology
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Biological processes related to Newborn Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1respiratory gaseous exchangeGO:0075859.9SFTPB, SFTPA1
2CDP-choline pathwayGO:0066579.7CHKB, CHPT1
3phosphatidylcholine biosynthetic processGO:0066569.5CHKB, CHPT1

Products for genes affiliated with Newborn Respiratory Distress Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Newborn Respiratory Distress Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet