MCID: NWC001
MIFTS: 54

Newcastle Disease malady

Infectious diseases category
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Summaries for Newcastle Disease

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Disease Ontology:8 A viral infectious disease that results in infection in birds and humans, has material basis in newcastle disease virus, which is transmitted by contact with feces and urine of an infected bird, or transmitted by fomites. the infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.

MalaCards based summary: Newcastle Disease, also known as newcastle's disease, is related to influenza and mumps, and has symptoms including An important gene associated with Newcastle Disease is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Cytosolic sensors of pathogen-associated DNA and Hepatitis C. The compounds acyclovir and fluticasone propionate have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and prostate, and related mouse phenotypes are skeleton and hematopoietic system.

Wikipedia:65 Newcastle disease is a contagious bird disease affecting many domestic and wild avian species; it is... more...

Aliases & Classifications for Newcastle Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt
See all sources

Newcastle Disease, Aliases & Descriptions:

Name: Newcastle Disease 8 10 44 62
Newcastle's Disease 8
 
Pseudo-Fowlpest 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology8 DOID:2929
MeSH34 D009521
NCIt39 C34849

Related Diseases for Newcastle Disease

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Diseases related to Newcastle Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1influenza30.4LBR, NEU1, IRF1, CXCL10, IFNB1
2mumps30.3NEU1, IRF1
3hepatitis30.2IFNB1, CXCL10
4adenocarcinoma30.0IRF1, CXCL10, IFNB1
5astrocytoma29.9IFNB1, CXCL10, IRF1
6measles29.7IFNB1, IRF1, LBR
7lung cancer29.7LBR, IRF1, IFNB1
8leukemia29.3CTRL, IFNB1, IRF1, LBR
9melanoma29.0LBR, NEU1, IRF1, CXCL10, IFNB1, CTRL
10avian influenza10.8
11bronchitis10.4
12laryngotracheitis10.4
13malaria10.4NEU1
14progressive multifocal leukoencephalopathy10.4IFNB1
15pancreatitis10.3
16dengue disease10.2NEU1, IFNB1
17lung adenocarcinoma10.2
18encephalitis10.2
19stomatitis10.2
20respiratory failure10.2NEU1, CXCL10
21severe acute respiratory syndrome10.2CTRL, CXCL10
22neutropenia10.2IFNB1, CXCL10
23gastric cancer10.1
24prostate cancer10.1
25peritonitis10.1
26prostatitis10.1
27myocarditis10.1IFNB1, IRF1
28cholera10.1IFNB1, NEU1
29berger disease10.1LBR, NEU1
30tetanus10.0LBR, NEU1
31colitis10.0CXCL10, IRF1
32idiopathic pulmonary fibrosis10.0CXCL10, LBR
33arthritis10.0
34hepatocellular carcinoma10.0
35hiv-110.0
36malignant glioma10.0
37pancreatic cancer10.0
38cryptosporidiosis10.0
39rift valley fever10.0
40tracheitis10.0
41phaeochromocytoma10.0
42eastern equine encephalitis10.0
43tonsillitis10.0
44rabies10.0
45malignant pleural mesothelioma10.0
46neuroblastoma10.0
47parainfluenza virus type 310.0
48graves' disease10.0CXCL10, IRF1
49pneumonia10.0CXCL10, IRF1, NEU1
50hepatitis c9.9IRF1, CXCL10, IFNB1

Graphical network of the top 20 diseases related to Newcastle Disease:



Diseases related to newcastle disease

Symptoms for Newcastle Disease

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Drugs & Therapeutics for Newcastle Disease

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Drug clinical trials:

Search ClinicalTrials for Newcastle Disease

Search NIH Clinical Center for Newcastle Disease

Genetic Tests for Newcastle Disease

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Anatomical Context for Newcastle Disease

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MalaCards organs/tissues related to Newcastle Disease:

32
Lung, T cells, Prostate, Testes, Brain, Bone, Kidney, Breast, Tonsil, Myeloid, Monocytes, Tongue, Trachea, Neutrophil

Animal Models for Newcastle Disease or affiliated genes

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MGI Mouse Phenotypes related to Newcastle Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.2IFNB1, IRF1, NEU1, LBR
2MP:00053977.6IFNB1, CXCL10, IRF1, NEU1, LBR
3MP:00053877.5LBR, NEU1, IRF1, CXCL10, IFNB1
4MP:00053767.3LBR, NEU1, IRF1, CXCL10, IFNB1

Publications for Newcastle Disease

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Articles related to Newcastle Disease:

(show top 50)    (show all 535)
idTitleAuthorsYear
1
Apoptotic induction of lung adenocarcinoma A549 cells infected by recombinant RVG Newcastle disease virus (rLa89RVG) inA vitro. (25322856)
2015
2
Analysis of synonymous codon usage in Newcastle disease virus hemagglutinin-neuraminidase (HN) gene and fusion protein (F) gene. (24426322)
2014
3
Newcastle disease virus (NDV) recombinants expressing infectious laryngotracheitis virus (ILTV) glycoproteins gB and gD protect chickens against ILTV and NDV challenges. (24829337)
2014
4
Development of Strand-Specific Real-Time RT-PCR to Distinguish Viral RNAs during Newcastle Disease Virus Infection. (25379553)
2014
5
Development of a reverse genetics system based on RNA polymerase II for Newcastle disease virus genotype VII. (25384536)
2014
6
In vitro and in vivo broad antiviral activity of peptides homologous to fusion glycoproteins of Newcastle disease virus and Marek's disease virus. (24412629)
2014
7
Recovery of avirulent, thermostable Newcastle disease virus strain NDV4-C from cloned cDNA and stable expression of an inserted foreign gene. (23657741)
2013
8
Molecular epidemiological investigation of velogenic Newcastle disease viruses from village chickens in Cambodia. (23764918)
2013
9
Preparation and Efficacy of Newcastle Disease Virus DNA Vaccine Encapsulated in PLGA Nanoparticles. (24386106)
2013
10
Complete genome sequence of a newcastle disease virus strain belonging to a recently identified genotype. (23405340)
2013
11
Characterization of newcastle disease viruses in wild and domestic birds in Luxembourg from 2006 to 2008. (23160119)
2013
12
Heterologous expression, characterization and evaluation of the matrix protein from Newcastle disease virus as a target for antiviral therapies. (23797330)
2013
13
Effects of the HN gene C-terminal extensions on the Newcastle disease virus virulence. (24037042)
2013
14
Characterization of Newcastle disease viruses isolated from cormorant and gull species in the United States in 2010. (22545538)
2012
15
Risk factors for avian influenza and Newcastle disease in smallholder farming systems, Madagascar highlands. (22130311)
2012
16
Biological characterization and phylogenetic analysis of a novel genetic group of Newcastle disease virus isolated from outbreaks in commercial poultry and from backyard poultry flocks in Pakistan. (22418457)
2012
17
Complete genome sequencing of a novel newcastle disease virus isolate circulating in layer chickens in the Dominican Republic. (22879619)
2012
18
Biological and phylogenetic characterization of a genotype VII Newcastle disease virus from Venezuela: efficacy of field vaccination. (22238433)
2012
19
Effect of immunosuppression on newcastle disease virus persistence in ducks with different immune status. (23738119)
2012
20
Surveillance for avian influenza and Newcastle disease in backyard poultry flocks in CA'te d'Ivoire, 2007-2009. (23520736)
2012
21
Molecular characterization of a recent Newcastle disease virus outbreak in Jordan. (22480768)
2012
22
Lack of detection of host associated differences in Newcastle disease viruses of genotype VIId isolated from chickens and geese. (22971647)
2012
23
A simple fluorescent labeling technique to study virus adsorption in Newcastle disease virus infected cells. (22112508)
2011
24
The matrix (M) protein of Newcastle disease virus binds to human bax through its BH3 domain. (21810274)
2011
25
Rescue of Newcastle disease virus from cloned cDNA using an RNA polymerase II promoter. (21327786)
2011
26
Virulent Newcastle disease virus elicits a strong innate immune response in chickens. (21177922)
2011
27
Detection and differentiation of virulent and avirulent strains of Newcastle disease virus by real-time PCR. (21192979)
2011
28
A single amino acid change, Q114R, in the cleavage-site sequence of Newcastle disease virus fusion protein attenuates viral replication and pathogenicity. (21677091)
2011
29
Immunogenicity of a truncated enterovirus 71 VP1 protein fused to a Newcastle disease virus nucleocapsid protein fragment in mice. (21978156)
2011
30
Newcastle disease virus-vectored rabies vaccine is safe, highly immunogenic, and provides long-lasting protection in dogs and cats. (21632762)
2011
31
Construction of a minigenome rescue system for Newcastle disease virus strain Italien. (21207083)
2011
32
Newcastle disease virus in Madagascar: identification of an original genotype possibly deriving from a died out ancestor of genotype IV. (21085573)
2010
33
The influence of the inactivating agent on the antigen content of inactivated Newcastle disease vaccines assessed by the in vitro potency test. (19716316)
2010
34
Avian influenza virus and Newcastle disease virus (NDV) surveillance in commercial breeding farm in China and the characterization of Class I NDV isolates. (20133090)
2010
35
Type I interferon-sensitive recombinant newcastle disease virus for oncolytic virotherapy. (20147405)
2010
36
Overexpression of Newcastle disease virus (NDV) V protein enhances NDV production kinetics in chicken embryo fibroblasts. (19730851)
2010
37
Respiratory tract immunization of non-human primates with a Newcastle disease virus-vectored vaccine candidate against Ebola virus elicits a neutralizing antibody response. (21034822)
2010
38
Evaluation of immunogenic potential of 75kDa and 56kDa proteins of newcastle disease virus (NDV). (21506496)
2010
39
Sequence and phylogenetic analysis of Newcastle disease virus genotypes isolated in Malaysia between 2004 and 2005. (19898736)
2010
40
Inhibition of host innate immune responses and pathogenicity of recombinant Newcastle disease viruses expressing NS1 genes of influenza A viruses. (20410312)
2010
41
Newcastle disease virus infection promotes Bax redistribution to mitochondria and cell death in HeLa cells. (19955813)
2010
42
Lycium barbarum polysaccharide inhibits the infectivity of Newcastle disease virus to chicken embryo fibroblast. (19962398)
2010
43
Molecular characterization of partial fusion gene and C-terminus extension length of haemagglutinin-neuraminidase gene of recently isolated Newcastle disease virus isolates in Malaysia. (20691110)
2010
44
Genetically engineered Newcastle disease virus for malignant melanoma therapy. (19242529)
2009
45
Optimization of human immunodeficiency virus gag expression by newcastle disease virus vectors for the induction of potent immune responses. (19004953)
2009
46
Newcastle disease outbreaks in Kazakhstan and Kyrgyzstan during 1998, 2000, 2001, 2003, 2004, and 2005 were caused by viruses of the genotypes VIIb and VIId. (19466536)
2009
47
Evidence for a role of mast cells in the mucosal injury induced by Newcastle disease virus. (19211524)
2009
48
Occurrence and transmission of Newcastle disease virus aerosol originating from infected chickens under experimental conditions. (19091492)
2009
49
Overexpression of thiol/disulfide isomerases enhances membrane fusion directed by the Newcastle disease virus fusion protein. (18829746)
2008
50
Experimental infections of wild birds with the viruses of eastern equine encephalitis, Newcastle disease and vesicular stomatitis. (14404590)
1959

Variations for Newcastle Disease

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Expression for genes affiliated with Newcastle Disease

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Expression patterns in normal tissues for genes affiliated with Newcastle Disease

Search GEO for disease gene expression data for Newcastle Disease.

Pathways for genes affiliated with Newcastle Disease

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Pathways related to Newcastle Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5IFNB1, CXCL10
29.4IFNB1, IRF1
39.4IFNB1, IRF1
49.4IFNB1, IRF1
5
Show member pathways
9.4IRF1, IFNB1
68.9IFNB1, CXCL10, IRF1
7
Show member pathways
8.9IFNB1, CXCL10, IRF1
8
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.9IRF1, CXCL10, IFNB1

Compounds for genes affiliated with Newcastle Disease

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Compounds related to Newcastle Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1acyclovir44 1111.0IFNB1, NEU1
2fluticasone propionate44 50 61 1112.8CXCL10, IFNB1
3il 10449.8CXCL10, IFNB1
4tarc449.8IFNB1, CXCL10
5ccl344 2810.8CXCL10, IFNB1
6indoleamine449.8IFNB1, IRF1
7ccl444 2810.8IFNB1, CXCL10
8inosine monophosphate449.7IFNB1, IRF1
9con a449.6NEU1, LBR
10chloroquine44 2 50 28 1113.6IFNB1, CXCL10
11tetracycline44 1110.5IFNB1, IRF1
12n-ethylmaleimide44 1110.5NEU1, CTRL
13pdtc449.5CTRL, IRF1
14guanosine 5-o-(3-thiotriphosphate)449.5CTRL, LBR
15infliximab44 50 1111.4CXCL10, LBR
16dbc-amp449.4LBR, IFNB1
17deferoxamine44 1110.4IRF1, LBR
182,5-oligoadenylate449.3IRF1, CXCL10, IFNB1
19polyinosinic-polycytidylic acid449.3IRF1, CXCL10, IFNB1
20poly(i-c)449.3IFNB1, CXCL10, IRF1
21ifn-alpha449.3IFNB1, CXCL10, IRF1
22adenine44 24 1111.3IRF1, CXCL10, IFNB1
23tamoxifen44 50 28 1112.2IRF1, IFNB1, CTRL
24zidovudine44 50 1111.2IFNB1, NEU1, LBR
25pge2449.2IRF1, CXCL10, IFNB1
26adenylate449.1IRF1, CXCL10, IFNB1
27neopterin449.1LBR, CXCL10, IFNB1
28superoxide44 2410.0CTRL, IFNB1, LBR
29chloramphenicol44 2 50 1112.0LBR, IRF1, IFNB1
30progesterone44 28 61 24 1112.9IFNB1, CXCL10, LBR
31purine44 249.9IFNB1, LBR
32estrogen448.9IFNB1, CXCL10, IRF1, NEU1
33cholesterol44 28 24 1111.8IFNB1, CXCL10, LBR
34ribavirin44 50 1110.7IFNB1, CXCL10, NEU1, LBR
35heparin44 28 24 1111.7LBR, NEU1, IFNB1, CTRL
36h2o2448.7LBR, NEU1, IFNB1, CTRL
37cysteine448.6LBR, NEU1, IFNB1, CTRL
38histamine44 28 2410.6LBR, NEU1, CXCL10, CTRL
39genistein44 28 61 2 24 1113.6LBR, CXCL10, IFNB1, CTRL
40dexamethasone44 50 28 1111.6IFNB1, CXCL10, LBR
41arginine448.5CTRL, IRF1, LBR
42rantes448.5IFNB1, CXCL10, IRF1, LBR
43thymidine44 249.5LBR, IRF1, CXCL10, IFNB1
44zinc44 249.5CTRL, IFNB1, IRF1, LBR
45lipid448.4LBR, IRF1, CXCL10, IFNB1
46cycloheximide448.1LBR, NEU1, IRF1, CXCL10, IFNB1
47serine448.1CTRL, IFNB1, IRF1, NEU1, LBR
48tyrosine447.9CTRL, IFNB1, CXCL10, IRF1, LBR
49calcium44 50 24 1110.9LBR, IRF1, CXCL10, IFNB1, CTRL
50retinoic acid44 248.6LBR, NEU1, IRF1, CXCL10, IFNB1, CTRL

GO Terms for genes affiliated with Newcastle Disease

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Biological processes related to Newcastle Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1type I interferon signaling pathwayGO:0603379.1IFNB1, IRF1
2positive regulation of transcription from RNA polymerase II promoterGO:0459448.9IFNB1, CXCL10, IRF1
3defense response to virusGO:0516078.8IFNB1, CXCL10, IRF1

Products for genes affiliated with Newcastle Disease

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Sources for Newcastle Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet