Newcastle Disease malady

Disease Ontology: A viral infectious disease that results in infection in birds and humans, has material basis in newcastle disease virus, which is transmitted by contact with feces and urine of an infected bird, or transmitted by fomites. the infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.⁶

MalaCards: Newcastle Disease, also known as newcastle disease (disorder), is related to parainfluenza virus type 3 and mumps, and has symptoms including conjunctivitis, headache and lacrimation in humans. An important gene associated with Newcastle Disease is IVNS1ABP (influenza virus NS1A binding protein), and among its related pathways are Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways and Immune response_IFN alpha/beta signaling pathway. The compounds ionomycin and pge2 have been mentioned in the context of this disorder. Affiliated tissues include lung, monocytes and t cells, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Wikipedia: Newcastle disease is a contagious bird disease affecting many domestic and wild avian species; it is...⁴⁴ more...

Aliases & Descriptions:

newcastle disease 6 8 32 43 newcastle disease (disorder) 6

newcastle's disease 6 pseudo-fowlpest 6

Diseases related to newcastle disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 279)

id	Related Disease	Score	Top Affiliating Genes
1	parainfluenza virus type 3	28.6	MX1, IL2, IFNA1, IFNB1, DDX58, NEU1
2	mumps	27.8	UMOD, IRF1, IL2RB, IFNB1, TNF, CXCL10
3	neuroblastoma	23.5	BIRC5, BIRC7, LGALS1, LGALS3, LGALS7, BAX
4	influenza	21.5	LGALS1, LGALS7, UMOD, MX1, BAX, LBR
5	melanoma	20.9	BIRC5, BIRC7, LGALS1, LGALS3, MX1, BAX
6	carcinoma	20.2	BIRC5, BIRC7, LGALS1, LGALS3, LGALS7, UMOD
7	respiratory syncytial virus infectious disease	13.7	IRF1, IFNB1, NEU1
8	hermansky-pudlak syndrome	13.6	MX1, IFNB1
9	kaposi's sarcoma	13.6	LBR, IFNA1, IFNB1, CXCL10
10	tick-borne encephalitis	13.6	LGALS3, IVNS1ABP
11	fetal parainfluenza virus type 3 syndrome	13.5	MX1, IFNA1, IFNB1, NEU1
12	relapsing-remitting multiple sclerosis	13.5	MX1, IFNA1, IFNB1
13	dengue disease	13.5	IVNS1ABP, IFNB1, PTPN11, NEU1
14	west nile virus	13.4	MX1, IVNS1ABP, IRF3, IFNA1, CXCL10
15	japanese encephalitis	13.4	IVNS1ABP, PTPN11
16	venezuelan equine encephalitis	13.4	LGALS3, IFNA1, IFNB1
17	hepatitis	13.4	IL2RB, IFNA1, IFNB1, CXCL10
18	21-hydroxylase deficiency	13.4	IL2RB, IFNA1, IFNB1
19	bell's palsy	13.2	MX1, IFNA1, TNF
20	hand, foot and mouth disease	13.1	MX1, IRF3, IRF7, IFNA1, IFNB1, EIF2S1
21	posterior uveitis	13.1	IL2RB, IFNA1, TNF
22	hypothyroidism	13.0	LGALS3, IFNA1, IFNB1
23	cryoglobulinemia	13.0	MX1, IFNA1, TNF, CXCL10
24	bladder urothelial papillary carcinoma	13.0	BIRC5, BIRC7, LGALS1, LGALS3
25	t-lymphocytopenia	13.0	LBR, IL2, IL2RB
26	acute pyelonephritis	13.0	LGALS7, TNF, CXCL10
27	hypersensitivity reaction type iv disease	13.0	LBR, IL2, IL2RB
28	pyelonephritis	13.0	LGALS7, UMOD, TNF, CXCL10
29	tropical spastic paraparesis	13.0	IL2, IL2RB, IFNB1
30	commensal bacterial infectious disease	12.9	MX1, LBR, IRF3, IFNB1, TNF
31	hairy cell leukemia	12.9	IL2, IL2RB, IFNA1, IFNB1
32	cutaneous lupus erythematosus	12.9	MX1, IRF7, IFNA1, TNF, CXCL10
33	sezary's disease	12.9	IL2, IL2RB, IFNA1
34	anaplastic carcinoma	12.9	LGALS1, LGALS3, TNFSF10
35	lymphadenitis	12.8	BAX, IL2, IFNB1
36	dermatomyositis	12.8	MX1, IFNA1, IFNB1, TNF, CXCL10
37	acquired immunodeficiency syndrome	12.8	LGALS1, LBR, IRF3, IL2, CTRL, CXCL10
38	thymoma	12.8	LBR, IL2, IFNA1, IFNB1, STK16
39	panniculitis	12.8	BAX, IL2RB, IFNB1, TNF
40	oral tuberculosis	12.8	IL2, TNF
41	laryngeal cancer	12.8	BIRC5, LGALS1, LGALS3, BAX, LBR
42	burkitt's lymphoma	12.8	BIRC5, LGALS1, BAX, IFNA1, PTPN11
43	rabies	12.7	MX1, IRF3, IRF7, IFNA1, DDX58, OCA2
44	cytomegalovirus retinitis	12.7	IL2, IFNB1, TNF
45	lymphocytic choriomeningitis	12.7	IRF3, IL2, IFNA1, TNF
46	progressive multifocal leukoencephalopathy	12.7	LBR, IL2, IFNB1, TNF
47	cervical squamous cell carcinoma	12.6	BIRC5, BAX, CD82, IFNA1
48	galactosemia	12.6	LGALS1, LGALS3, MX1, IFNA1, TNF, CXCL10
49	autoimmune hemolytic anemia	12.6	IL2, IFNA1, IFNB1, TNF
50	primary effusion lymphoma	12.6	BIRC5, BAX, IRF3, IFNA1, TNFSF10

Symptoms: conjunctivitis, headache, lacrimation in humans, gasping, coughing, twisting of head, circling, complete paralysis, watery diarrhea, reduced egg production in birds.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to newcastle disease:

²²

MGI Mouse Phenotypes related to newcastle disease:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.3	OCA2, EIF2S1, DDX58, IRF1, LGALS3
2	liver/biliary system phenotype	MP:0005370	9.3	IL2, DDX58, OCA2
3	skeleton phenotype	MP:0005390	8.6	NEU1, PTPN11, TNFSF10, IFNB1, IRF1, BAX
4	immune system phenotype	MP:0005387	7.6	LGALS1, NEU1, CXCL10, PTPN11, TNF, IFNB1
5	mortality/aging	MP:0010768	7.2	PTPN11, DDX58, EIF2S1, OCA2, NEU1, TNFSF10
6	homeostasis/metabolism phenotype	MP:0005376	6.3	MAPK1, IFNB1, TNFSF10, PTPN11, DDX58, EIF2S1
7	cellular phenotype	MP:0005384	5.3	MAPK1, IFNB1, TNF, TNFSF10, PTPN11, DDX58

Articles related to newcastle disease:

(show all 23)

id	Title	Authors	Year	Affiliating Genes
1	Importance of retinoic acid-inducible gene I and of r eceptor for type I interferon for cellular resistance to infection by Newcastle disease virus. (21971670)	Fournier P.... Schirrmacher V.	2012	DDX58
2	The matrix (M) protein of newcastle disease virus bin ds to human bax through its BH3 domain. (21810274)	Molouki A.... Yusoff K.	2011	BAX
3	The oncolytic activity of Newcastle disease virus NDV -HUJ on chemoresistant primary melanoma cells is dependent on the proapoptotic activity of the inhibitor of apoptosis protein Livin. (19864394)	Lazar I.... Ben-Yehuda D.	2010	BIRC7
4	Newcastle disease virus infection promotes Bax redist ribution to mitochondria and cell death in HeLa cells. (19955813)	Molouki A.... Yusoff K.	2010	BAX
5	Enhancement of oncolytic properties of recombinant newcastle disease virus through antagonism of cellular innate immune responses. (19209145)	Zamarin D.... Fong Y.	2009	PTPN11
6	Selective oncolytic effect of an attenuated Newcastle disease virus (NDV-HUJ) in lung tumors. (18535620)	Yaacov B.... Zakay-Rones Z.	2008	IFNB1, IFNA1
7	Recombinant Newcastle disease virus expressing human interleukin-2 serves as a potential candidate for tumor therapy. (18538434)	Zhao H.... Schirrmacher V.	2008	IL2
8	Activation of human T cells by a tumor vaccine infected with recombinant Newcastle disease virus producing IL-2. (18813797)	Janke M.... Schirrmacher V.	2008	IL2
9	Effects of Newcastle disease virus on the expression of survivin and cell cycle in human tongue squamous carcinoma TSCCa cells (18495590)	Wan X.Q.... Wang X.J.	2008	BIRC5
10	p53-independent endoplasmic reticulum stress-mediated cytotoxicity of a Newcastle disease virus strain in tumor cell lines. (17215292)	Fabian Z.... Csatary L.K.	2007	EIF2S1
11	Differentially regulated interferon response determin es the outcome of Newcastle disease virus infection in normal and tumor cell li nes. (16698995)	Krishnamurthy S.... Portner A.	2006	IFNB1
12	Tumor selective replication of Newcastle disease virus: association with defects of tumor cells in antiviral defence. (16470838)	Fiola C.... Schirrmacher V.	2006	MX1
13	Structural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle disease virus. (16575531)	Ryan C.... Taylor G.	2006	NEU1
14	Selective gene transfer in vitro to tumor cells via recombinant Newcastle disease virus. (15605075)	Bian H.... Schirrmacher V.	2005	IL2RB
15	Newcastle disease virus neuraminidase primes neutrophils for stimulation by galectin-3 and formyl-Met-Leu-Phe. (15242763)	Almkvist J.... Karlsson A.	2004	LGALS3, NEU1
16	Inhibition of parainfluenza virus type 3 and Newcastle disease virus hemagglutinin-neuraminidase receptor binding: effect of receptor avidity and steric hindrance at the inhibitor binding sites. (15564499)	Porotto M.... Moscona A.	2004	NEU1
17	TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus. (12574346)	Washburn B.... Walczak H.	2003	TNFSF10
18	Newcastle disease virus V protein is a determinant of host range restriction. (12915566)	Park M.S.... Palese P.	2003	IVNS1ABP
19	Induction of apoptosis by a Newcastle disease virus v accine (MTH-68/H) in PC12 rat phaeochromocytoma cells. (11299726)	FA!biA!n Z.... SzeberAcnyi J.	2001	MAPK1
20	Retinoic acid enhances killing of neuroblastoma cells by Newcastle disease virus. (8263678)	Reichard K.W.... Reyes H.M.	1993	NEU1
21	Serum protease inhibitor abrogation of Newcastle disease virus enhancement of cytolysis by recombinant tumor necrosis factors alpha and beta. (2296051)	Rood P.A.... Kelley K.W.	1990	TNF, CTRL
22	Alternative mechanisms for gene activation induced by poly(rI).poly(rC) and Newcastle disease virus. (3203696)	Lammers R.... Collins J.	1988	CCDC130
23	A mucoprotein derived from human urine which reacts with influenza, mumps, and Newcastle disease viruses. (14907962)	Tamm I.... HORSFALL F.L.	1952	UMOD

Genes related to newcastle disease according to GeneCards:

(show all 43)

id	Symbol	Description	Score	GeneCards Section Context
1	IVNS1ABP	influenza virus NS1A binding protein	11.0	Publications
2	NEU1	sialidase 1 (lysosomal sialidase)	11.0	Publications
3	LBR	lamin B receptor	11.0
4	LGALS1	lectin, galactoside-binding, soluble, 1	11.0
5	IRF3	interferon regulatory factor 3	11.0
6	IRF1	interferon regulatory factor 1	11.0
7	IFNB1	interferon, beta 1, fibroblast	11.0	Publications
8	CXCL10	chemokine (C-X-C motif) ligand 10	11.0
9	IFNA1	interferon, alpha 1	11.0	Publications
10	CCDC130	coiled-coil domain containing 130	11.0	Functions, Publications
11	DCTN6	dynactin 6	11.0	Disorders
12	LGALS7	lectin, galactoside-binding, soluble, 7	11.0
13	COMMD9	COMM domain containing 9	11.0	Disorders
14	STK16	serine/threonine kinase 16	11.0
15	RPL32	ribosomal protein L32	11.0
16	CTRL	chymotrypsin-like	11.0	Publications
17	BIRC7	baculoviral IAP repeat containing 7	11.0	Publications
18	HAUS1	HAUS augmin-like complex, subunit 1	11.0
19	GRK1	G protein-coupled receptor kinase 1	11.0
20	GRHPR	glyoxylate reductase/hydroxypyruvate reductase	11.0
21	RNMT	RNA (guanine-7-) methyltransferase	11.0	Disorders
22	RPS15A	ribosomal protein S15a	11.0
23	UMOD	uromodulin	11.0	Publications
24	CDCA7L	cell division cycle associated 7-like	11.0
25	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11.0	Publications
26	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	11.0	Publications
27	IRF7	interferon regulatory factor 7	11.0
28	EIF2S1	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	11.0	Publications
29	UBN1	ubinuclein 1	11.0
30	CD82	CD82 molecule	11.0
31	MSRB3	methionine sulfoxide reductase B3	11.0
32	PTPN11	protein tyrosine phosphatase, non-receptor type 11	11.0	Publications
33	RALGAPA1	Ral GTPase activating protein, alpha subunit 1 (catalytic)	11.0
34	IL2RB	interleukin 2 receptor, beta	11.0	Publications
35	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
36	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	11.0	Publications
37	OCA2	oculocutaneous albinism II	11.0
38	BAX	BCL2-associated X protein	11.0	Publications
39	CMIP	c-Maf inducing protein	11.0
40	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications
41	IL2	interleukin 2	11.0	Publications
42	TNF	tumor necrosis factor	11.0	Publications
43	MAPK1	mitogen-activated protein kinase 1	11.0	Publications

Pathways related to newcastle disease according to GeneDecks:

(show all 38)

id	Pathway	Score	Top Affiliating Genes
1	Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways10	10.4	IRF3
2	Immune response_IFN alpha/beta signaling pathway41	10.2	PTPN11, IFNB1, IFNA1, IRF1
3	Immune response IFN alpha/beta signaling pathway10	10.2	PTPN11, IFNB1, IFNA1, IRF1
4	RIG-I-like receptor signaling pathway20	10.2	CXCL10, DDX58, IFNB1, IRF7, IRF3
5	Cytosolic DNA-sensing pathway20	10.0	CXCL10, DDX58, IFNB1, IFNA1, IRF7, IRF3
6	Immune System38	9.9	DCTN6, DDX58, IRF1, MX1, LGALS3
7	Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway41	9.9	IRF3, IFNA1, IFNB1
8	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.8	IL2RB, IL2
9	IL-6 Pathway36	9.4	CXCL10, TNFSF10, MAPK1, BAX
10	NF-kappaB Signaling3	9.4	DDX58, TNF, IRF7, IRF3, IRF1
11	Jak-STAT signaling pathway20	9.3	IL2, IL2RB, IFNA1, IFNB1, PTPN11
12	Cytokine Network36	9.2	TNF, IFNB1, IFNA1, IL2
13	Pertussis20	9.1	TNF, MAPK1, IRF3, IRF1
14	Immune response_IL-2 activation and signaling pathway41	9.1	PTPN11, MAPK1, IL2RB, IL2
15	Immune response IL-2 activation and signaling pathway10	9.0	PTPN11, MAPK1, IL2RB, IL2
16	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.0	IL2, IL2RB, TNF
17	Toll-like receptor signaling pathway20	8.9	CXCL10, TNF, IFNB1, IFNA1, MAPK1, IRF7
18	Natural killer cell mediated cytotoxicity20	8.7	PTPN11, TNFSF10, TNF, IFNB1, IFNA1, MAPK1
19	Tuberculosis20	8.7	TNF, IFNB1, IFNA1, MAPK1, BAX
20	Immune response_MIF-mediated glucocorticoid regulation41	8.6	TNF, MAPK1, IL2
21	Apoptosis Signaling Pathways37	8.6	TNFSF10, TNF, BAX, BIRC7, BIRC5
22	Immune response MIF-mediated glucocorticoid regulation10	8.6	TNF, MAPK1, IL2
23	Hepatitis C20	8.5	EIF2S1, DDX58, TNF, IFNB1, IFNA1, MAPK1
24	Measles20	8.5	IFNB1, TNFSF10, DDX58, EIF2S1, IFNA1, IL2RB
25	all-trans-Retinoic Acid Signaling in Brain36	8.4	CXCL10, TNFSF10, TNF, IL2, BAX
26	Cytokine-cytokine receptor interaction20	8.4	CXCL10, TNFSF10, TNF, IFNB1, IFNA1, IL2RB
27	RAR-Gamma-RXR-Alpha Degradation36	8.4	CXCL10, TNFSF10, TNF, IL2, BAX
28	JAK-STAT Pathway36	8.4	TNFSF10, IFNB1, IFNA1, MAPK1, IL2RB, IL2
29	Apoptosis and Autophagy3	8.3	PTPN11, TNFSF10, TNF, BAX, LGALS1, BIRC7
30	Glucocorticoid Receptor Signaling36	8.2	TNFSF10, MAPK1, IL2RB, IL2, BAX
31	MIF Mediated Glucocorticoid Regulation36	8.0	CXCL10, TNFSF10, TNF, MAPK1, IL2, BAX
32	MIF Regulation of Innate Immune Cells36	8.0	CXCL10, TNFSF10, TNF, MAPK1, IL2, BAX
33	PEDF Induced Signaling36	8.0	CXCL10, TNFSF10, TNF, MAPK1, IL2, BAX
34	Endothelin-1 Signaling Pathway36	7.9	CXCL10, TNFSF10, TNF, MAPK1, IL2, BAX
35	Influenza A20	7.9	MX1, CXCL10, EIF2S1, DDX58, TNFSF10, TNF
36	STAT3 Pathway36	7.7	CXCL10, TNFSF10, TNF, MAPK1, IL2RB, IL2
37	Antioxidant Action of Vitamin-C36	7.5	CXCL10, TNFSF10, TNF, MAPK1, IL2RB, IL2
38	MAPK Family Pathway36	7.5	TNFSF10, TNF, MAPK1, IL2RB, IL2, BAX

Compounds related to newcastle disease according to GeneDecks:

(show top 50)    (show all 123)

id	Compound	Score	Top Affiliating Genes
1	ionomycin32	10.6	EIF2S1
2	pge232	10.5	CXCL10, IRF1
3	rebif32	10.4	IFNA1, MX1, IFNB1
4	avonex32	10.3	MX1, IFNA1, IFNB1
5	threonine32	10.3	GRK1, IL2RB, IFNB1
6	egcg32	10.2	CTRL
7	h2o232	9.9	PTPN11, LBR, LGALS3, CTRL, IFNB1
8	inosine monophosphate32	9.9	IFNA1, IRF3, IRF1, BIRC5, IFNB1
9	vegf32	9.7	LGALS3, MAPK1, EIF2S1, IFNB1
10	rapamycin32 42	10.7	LGALS1, EIF2S1, IL2, IL2RB
11	con a32	9.6	LBR, LGALS1, IL2, IL2RB, NEU1
12	ribavirin32 34 9 9	12.6	IFNA1, IL2, IFNB1, CXCL10, NEU1, MX1
13	levamisole32 9 9	11.6	NEU1, IFNA1, IL2RB, IL2
14	zidovudine32 9 9	11.5	IFNB1, IFNA1, IL2, LBR, TNFSF10, NEU1
15	imiquimod32 42 9 9	12.3	IFNB1, MX1, TNF, IFNA1
16	indoleamine32	9.0	IFNB1, IFNA1, TNF, IRF1
17	ly29400232	9.0	MAPK1, TNF, PTPN11, EIF2S1
18	retinoid32	9.0	IFNA1, LGALS1, BAX, IRF1, IL2RB, TNFSF10
19	suberoylanilide hydroxamic acid32	8.9	MAPK1, TNFSF10, BIRC5, BAX, IRF1
20	sb 20358032 42	9.8	EIF2S1, PTPN11, IFNB1, IRF1, BIRC5, TNF
21	etoposide32 42 9 9	11.8	BAX, LGALS3, TNFSF10, BIRC5, PTPN11, LGALS1
22	il 1032	8.8	TNF, IFNB1, IL2RB, IL2, CXCL10
23	poly(i-c)32	8.8	IFNB1, IRF3, IRF7, IFNA1, TNF, DDX58
24	fludarabine32 9 9	10.7	IFNA1, IL2, BAX, BIRC5, TNFSF10
25	arsenite32 18	9.6	MAPK1, LBR, IFNA1, TNFSF10, EIF2S1, BAX
26	neopterin32	8.5	CXCL10, TNF, IFNB1, IFNA1, IL2RB, MX1
27	mg 13232 42	9.5	BAX, CTRL, MAPK1, TNFSF10, BIRC5
28	ifn-alpha32	8.5	MX1, IRF1, IRF3, IRF7, IL2, CXCL10
29	5fluorouracil32	8.4	BIRC7, BAX, IL2, BIRC5, IFNA1, IFNB1
30	2,5-oligoadenylate32	8.3	IRF1, IL2, MX1, IL2RB, IFNA1, IFNB1
31	polyinosinic-polycytidylic acid32	8.3	IRF1, IRF3, IL2, IFNA1, IFNB1, TNF
32	tamoxifen32 34 9 9	11.2	BIRC5, CTRL, TNFSF10, IFNB1, IFNA1, BAX
33	thalidomide32 42 9 9	11.2	IL2, TNFSF10, TNF, IFNA1, BIRC5
34	triptolide32	8.1	MAPK1, TNF, TNFSF10, IL2, BAX
35	troglitazone32 42 9 9	10.9	BAX, IRF1, TNF, TNFSF10, EIF2S1, MAPK1
36	superoxide32 18	8.9	EIF2S1, IFNB1, LBR, TNF, TNFSF10, CTRL
37	curcumin32	7.8	TNF, CTRL, MAPK1, EIF2S1, BAX, BIRC5
38	rantes32	7.7	MX1, LBR, IRF1, IRF3, TNF, IFNB1
39	butyrate32	7.6	MAPK1, TNFSF10, IRF1, BAX, LGALS1, BIRC5
40	thymidine32 18	8.3	MAPK1, IL2, CXCL10, IFNA1, IFNB1, TNF
41	lipid32	7.2	CXCL10, EIF2S1, LGALS1, TNF, PTPN11, LGALS3
42	cisplatin32 34 9 9	10.1	IFNB1, PTPN11, TNFSF10, IFNA1, IL2RB, MAPK1
43	actinomycin d32	7.1	TNF, IFNB1, IFNA1, IL2, IRF1, BAX
44	nitric oxide32 9 18 9	10.0	TNF, PTPN11, EIF2S1, CXCL10, BIRC5, IRF1
45	dexamethasone32 42 34 9 9	11.0	TNFSF10, IFNB1, BIRC5, IL2, LGALS1, LBR
46	genistein32 9 18 9	9.9	CXCL10, BAX, BIRC5, CTRL, TNFSF10, TNF
47	tyrosine32	6.6	CXCL10, EIF2S1, CTRL, TNFSF10, CD82, IFNB1
48	retinoic acid32 42 18	8.5	LGALS3, BIRC5, LGALS7, BAX, LBR, TNFSF10
49	cycloheximide32	6.0	IL2RB, BAX, MAPK1, IFNA1, IFNB1, TNF
50	serine32	5.4	MAPK1, IL2RB, IL2, GRK1, IFNA1, IFNB1

Cellular components related to newcastle disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	6.0	RALGAPA1, OCA2, RPS15A, DDX58, PTPN11, GRHPR

Biological processes related to newcastle disease according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of MyD88-dependent toll-like receptor signaling pathway	GO:034124	10.3	IRF1, IRF7
2	cellular response to dsRNA	GO:071359	10.3	IRF1, IRF3
3	defense response to virus	GO:051607	10.2	IRF1, IRF3, IFNB1, CXCL10
4	MDA-5 signaling pathway	GO:039530	10.2	IRF3, IRF7
5	positive regulation of interferon-alpha production	GO:032727	10.2	IRF3, IRF7, DDX58
6	positive regulation of interferon-beta production	GO:032728	10.1	DDX58, IRF7, IRF3, IRF1
7	interferon-gamma-mediated signaling pathway	GO:060333	9.9	PTPN11, IRF7, IRF3, IRF1
8	regulation of adaptive immune response	GO:002819	9.9	IRF1, IRF7
9	type I interferon-mediated signaling pathway	GO:060337	9.8	PTPN11, IFNB1, IRF7, IRF3, IRF1, MX1
10	cytokine-mediated signaling pathway	GO:019221	9.5	PTPN11, IFNB1, IL2RB, IRF7, IRF3, IRF1
11	negative regulation of viral genome replication	GO:045071	9.3	MX1, IFNB1, TNF
12	innate immune response	GO:045087	9.0	DDX58, IFNB1, MAPK1, IRF7, IRF3, MX1
13	response to virus	GO:009615	8.9	MX1, RPS15A, DDX58, TNF, IFNB1, CCDC130
14	virus-host interaction	GO:019048	8.8	DDX58, MAPK1, IL2RB, IRF3, IVNS1ABP, BAX
15	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	8.8	TNFSF10, TNF, IFNB1, BAX
16	induction of apoptosis	GO:006917	8.2	TNFSF10, TNF, IFNB1, MAPK1, IRF3, IRF1

Molecular functions related to newcastle disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	4.7	BIRC5, CCDC130, TNF, TNFSF10, PTPN11, DDX58