Aliases & Classifications for Newcastle Disease

MalaCards integrated aliases for Newcastle Disease:

Name: Newcastle Disease 12 51 41 14 69
Newcastle's Disease 12
Pseudo-Fowlpest 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2929
MeSH 41 D009521
NCIt 46 C34849
UMLS 69 C0027983

Summaries for Newcastle Disease

Disease Ontology : 12 A viral infectious disease that results_in infection in birds and humans, has material basis in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.

MalaCards based summary : Newcastle Disease, also known as newcastle's disease, is related to parainfluenza virus type 3 and measles, and has symptoms including conjunctivitis, headache and lacrimation in humans. An important gene associated with Newcastle Disease is IFNB1 (Interferon Beta 1), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. Affiliated tissues include lung, eye and t cells, and related phenotypes are cellular and hematopoietic system

Wikipedia : 72 Newcastle disease is a contagious viral bird disease affecting many domestic and wild avian species; it... more...

Related Diseases for Newcastle Disease

Diseases related to Newcastle Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 parainfluenza virus type 3 30.1 IFNB1 NEU1
2 measles 29.7 DDX58 IFNA1 IFNB1
3 hepatitis 28.7 DDX58 IFNA1 IRF3
4 hepatocellular carcinoma 28.0 BAX CASP3 CASP9 IFNA1 MAPK1
5 influenza 10.6
6 avian influenza 10.5
7 respiratory syncytial virus infectious disease 10.4 IFNB1 NEU1
8 oral erosive lichen 10.4 IFNA1 IFNB1
9 pseudo-torch syndrome 1 10.3 IFNA1 IFNB1
10 bronchitis 10.2
11 laryngotracheitis 10.2
12 septicemic plague 10.2 IFNB1 IRF3
13 spinal cord astrocytoma 10.1 BSG IFNB1
14 pancreatitis 10.1
15 la crosse encephalitis 10.0 DDX58 IFNB1 IRF3
16 mucositis 10.0
17 blood group, i system 10.0
18 adenocarcinoma 10.0
19 severe acute respiratory syndrome 10.0 IFNA1 IFNB1 IRF3
20 west nile virus 9.9 DDX58 IFNA1 IRF3
21 rabies 9.9
22 prostatitis 9.9
23 melanoma 9.9
24 encephalitis 9.9
25 stomatitis 9.9
26 glioma 9.9
27 kaposi sarcoma 9.9 IFNA1 IFNB1 IRF3
28 vaccinia 9.9 IFNA1 IFNB1 IRF3
29 prostate cancer 9.8
30 lung cancer 9.8
31 aging 9.8
32 gastric cancer 9.8
33 multiple mitochondrial dysfunctions syndrome 5 9.8
34 peritonitis 9.8
35 cerebral hypoxia 9.8 CASP3 CASP9
36 viral infectious disease 9.8 DDX58 IFNA1 IFNB1 IRF3
37 herpes simplex 9.7 DDX58 IFNA1 IFNB1 IRF3
38 hepatitis c 9.7 DDX58 IFNA1 IFNB1 IRF3
39 blood group--diego system 9.7
40 polykaryocytosis inducer 9.7
41 neuraminidase deficiency 9.7
42 neuroblastoma 9.7
43 pancreatic cancer 9.7
44 lung disease, immunodeficiency, and chromosome breakage syndrome 9.7
45 arthritis 9.7
46 leukemia 9.7
47 malignant glioma 9.7
48 pancreas adenocarcinoma 9.7
49 phaeochromocytoma 9.7
50 oral squamous cell carcinoma 9.7

Graphical network of the top 20 diseases related to Newcastle Disease:



Diseases related to Newcastle Disease

Symptoms & Phenotypes for Newcastle Disease

Symptoms:

12
  • conjunctivitis
  • headache
  • lacrimation in humans
  • gasping
  • coughing
  • twisting of head
  • circling
  • complete paralysis
  • watery diarrhea
  • reduced egg production in birds

UMLS symptoms related to Newcastle Disease:


discharge from eye

MGI Mouse Phenotypes related to Newcastle Disease:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.16 CASP3 CASP9 BAX CD36 DDX58 VHL
2 hematopoietic system MP:0005397 10.16 IFNB1 CASP9 BAX CD36 BSG DDX58
3 immune system MP:0005387 10.14 IFNB1 CASP9 IRF3 BAX CD36 BSG
4 growth/size/body region MP:0005378 10.13 DDX58 CASP3 CASP9 BAX CD36 BSG
5 homeostasis/metabolism MP:0005376 10.09 DDX58 CASP3 IFNB1 BAX CD36 IRF3
6 endocrine/exocrine gland MP:0005379 10.04 CASP3 CASP9 BAX CD36 BSG VHL
7 liver/biliary system MP:0005370 9.85 CD36 BSG DDX58 VHL MAPK1 NEU1
8 muscle MP:0005369 9.8 CASP3 BAX CD36 VHL MAPK1 NEU1
9 neoplasm MP:0002006 9.65 DDX58 IFNB1 BAX VHL MAPK1
10 respiratory system MP:0005388 9.63 CASP3 CASP9 BAX BSG MAPK1 NEU1
11 skeleton MP:0005390 9.5 CASP3 IFNB1 BAX CD36 VHL MAPK1
12 taste/olfaction MP:0005394 8.92 CASP9 CD36 CASP3 MAPK1

Drugs & Therapeutics for Newcastle Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Newcastle Disease Virus (NDV) for Cancer Patients Resistant to Conventional Anti-cancer Modalities Withdrawn NCT00348842 Phase 2

Search NIH Clinical Center for Newcastle Disease

Cochrane evidence based reviews: newcastle disease

Genetic Tests for Newcastle Disease

Anatomical Context for Newcastle Disease

MalaCards organs/tissues related to Newcastle Disease:

38
Lung, Eye, T Cells, Prostate, Monocytes, Testes, Brain

Publications for Newcastle Disease

Articles related to Newcastle Disease:

(show top 50) (show all 692)
# Title Authors Year
1
Antitumor effect of the Newcastle disease viral hemagglutinin-neuraminidase gene is expressed through an oncolytic adenovirus effect in osteosarcoma cells. ( 29438228 )
2018
2
Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine. ( 29399179 )
2018
3
Newcastle disease virus co-expressing interleukin 7 and interleukin 15 modified tumor cells as a vaccine for cancer immunotherapy. ( 29224228 )
2018
4
Immune responses of mature chicken bone-marrow-derived dendritic cells infected with Newcastle disease virus strains with differing pathogenicity. ( 29397456 )
2018
5
Evaluation of spray and oral delivery of Newcastle disease I2 vaccine in chicken reared by smallholder farmers in central Ethiopia. ( 29439696 )
2018
6
Evaluation of the effect of live LaSota Newcastle disease virus vaccine as primary immunization on immune development in broilers. ( 29211892 )
2018
7
Dendritic cell targeted HIV-1 gag protein vaccine provides help to a recombinant Newcastle disease virus vectored vaccine including mobilization of protective CD8<sup>+</sup>T cells. ( 29205929 )
2018
8
Risk factors for Newcastle disease in broiler farms in Israel. ( 29290305 )
2018
9
Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines. ( 29352240 )
2018
10
Whole-genome sequencing of genotype VI Newcastle disease viruses from formalin-fixed paraffin-embedded tissues from wild pigeons reveals continuous evolution and previously unrecognized genetic diversity in the U.S. ( 29329546 )
2018
11
Acute phase proteins and stress markers in the immediate response to a combined vaccination against Newcastle disease and infectious bronchitis viruses in specific pathogen free (SPF) layer chicks. ( 29182756 )
2018
12
Potent Inhibitors against Newcastle Disease Virus Hemagglutinin-Neuraminidase. ( 29231283 )
2018
13
Evaluation of blood monocyte and lymphocyte population in broiler chicken after vaccination and experimental challenge with Newcastle disease virus. ( 28778320 )
2017
14
Corrigendum to "Safety and Clinical Usage of Newcastle Disease Virus in Cancer Therapy". ( 29333441 )
2017
15
Molecular evolution and epidemiological links study of Newcastle disease virus isolates from 1995 to 2016 in Iran. ( 28864876 )
2017
16
Newcastle disease virus vectored infectious laryngotracheitis vaccines protect commercial broiler chickens in the presence of maternally derived antibodies. ( 28052812 )
2017
17
Different Origins of Newcastle Disease Virus Hemagglutinin-Neuraminidase Protein Modulate the Replication Efficiency and Pathogenicity of the Virus. ( 28878757 )
2017
18
Efficacy of thermostable I-2 Newcastle disease vaccine compared to B1 commercial vaccine in broiler chicken. ( 28775749 )
2017
19
Newcastle disease virus vectored vaccines as bivalent or antigen delivery vaccines. ( 28775971 )
2017
20
Evaluating the efficacy of LaSota vaccination induced protection in chickens upon challenge with a genotype IV strain of Newcastle disease virus. ( 29291221 )
2017
21
Genetically engineered oncolytic Newcastle disease virus mediates cytolysis of prostate cancer stem like cells. ( 28935568 )
2017
22
Spillover of Newcastle disease viruses from poultry to wild birds in Guangdong province, southern China. ( 28935610 )
2017
23
The glutamic residue at position 402 in the C-terminus of Newcastle disease virus nucleoprotein is critical for the virus. ( 29234115 )
2017
24
Detection of specific antigens of Newcastle disease virus using an absorbed Western blotting method. ( 28775747 )
2017
25
New real time and conventional RT-PCRs for updated molecular diagnosis of infectious bronchitis virus infection (IBV) in chickens in Egypt associated with frequent co-infections with avian influenza and Newcastle Disease viruses. ( 28336367 )
2017
26
Newcastle disease virus mediates pancreatic tumor rejection via NK cell activation and prevents cancer relapse by prompting adaptive immunity. ( 28857157 )
2017
27
Newcastle disease virus-based H5 influenza vaccine protects chickens from lethal challenge with a highly pathogenic H5N2 avian influenza virus. ( 29263888 )
2017
28
Comprehensive analysis of amino acid sequence diversity at the F protein cleavage site of Newcastle disease virus in fusogenic activity. ( 28863165 )
2017
29
Alternative methods to compare safety of live-attenuated respiratory Newcastle disease vaccines in young chicks. ( 28823993 )
2017
30
Comparison of the efficiency of different newcastle disease virus reverse genetics systems. ( 28867302 )
2017
31
Newcastle disease virus from domestic mink, China, 2014. ( 28061999 )
2017
32
Adenoviral-expressed recombinant granulocyte monocyte colony-stimulating factor (GM-CSF) enhances protective immunity induced by inactivated Newcastle Disease Virus (NDV) vaccine. ( 28698014 )
2017
33
Induction of antitumor response to fibrosarcoma by Newcastle disease virus-infected tumor vaccine. ( 28864944 )
2017
34
Effects of the HN Antigenic Difference between the Vaccine Strain and the Challenge Strain of Newcastle Disease Virus on Virus Shedding and Transmission. ( 28809802 )
2017
35
Analysis of molecular evolution of nucleocapsid protein in Newcastle disease virus. ( 29228598 )
2017
36
Characterization of a novel VIIl sub-genotype of Newcastle disease virus circulating in Iran. ( 28874068 )
2017
37
Resistant and susceptible chicken lines show distinctive responses to Newcastle disease virus infection in the lung transcriptome. ( 29281979 )
2017
38
Recombinant Newcastle disease virus expressing the infectious bronchitis virus S1 gene protects chickens against Newcastle disease virus and infectious bronchitis virus challenge. ( 28342665 )
2017
39
Protective efficacy of combined trivalent inactivated ISA 71 oil adjuvant vaccine against avian influenza virus subtypes (H9N2 and H5N1) and Newcastle disease virus. ( 29184367 )
2017
40
The role of vaccination in risk mitigation and control of Newcastle disease in poultry. ( 28951084 )
2017
41
A novel immunosensor based on excessively tilted fiber grating coated with gold nanospheres improves the detection limit of Newcastle disease virus. ( 28888179 )
2017
42
Two mutations in the HR2 region of Newcastle disease virus fusion protein with a cleavage motif "RRQRRL" are critical for fusogenic activity. ( 28946881 )
2017
43
Tracing the origins of genotype VIIh Newcastle disease in southern Africa. ( 29178267 )
2017
44
Efficacy of vaccination with La Sota strain vaccine to control Newcastle disease in village chickens in Nepal. ( 27987111 )
2017
45
Complete Genome Sequence of a Newcastle Disease Genotype XIII Virus Isolated from Indigenous Chickens in Zambia. ( 28839026 )
2017
46
Molecular characterization of genotype XIIIb Newcastle disease virus from central India during 2006-2012: Evidence of its panzootic potential. ( 27497893 )
2016
47
Atrophy of the lymphoid organs and suppression of antibody response caused by velogenic Newcastle disease virus infection in chickens. ( 27645826 )
2016
48
Identification of 2'-5'-Oligoadenylate Synthetase-Like Gene in Goose: Gene Structure, Expression Patterns, and Antiviral Activity Against Newcastle Disease Virus. ( 27576097 )
2016
49
HN protein of Newcastle disease virus sensitizes HeLa cells to TNF-I+-induced apoptosis by downregulating NF-I_B expression. ( 27294845 )
2016
50
Derivation of chicken induced pluripotent stem cells tolerant to Newcastle disease virus-induced lysis through multiple rounds of infection. ( 27919263 )
2016

Variations for Newcastle Disease

Expression for Newcastle Disease

Search GEO for disease gene expression data for Newcastle Disease.

Pathways for Newcastle Disease

Pathways related to Newcastle Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 CASP3 CASP9 CD36 DDX58 IFNA1 IFNB1
2
Show member pathways
13.23 BSG CD36 IFNA1 IFNB1 IRF3 MAPK1
3
Show member pathways
13.23 CASP3 CD36 DDX58 IFNA1 IFNB1 IRF3
4
Show member pathways
12.96 BAX CASP3 CASP9 KLK3 MAPK1
5
Show member pathways
12.88 CD36 IFNA1 IFNB1 IRF3 MAPK1
6
Show member pathways
12.8 BAX CASP3 CASP9 MAPK1
7
Show member pathways
12.77 BAX CASP3 CASP9 IFNA1 IFNB1 IRF3
8
Show member pathways
12.72 BAX CASP3 CASP9 IRF3 MAPK1
9
Show member pathways
12.63 DDX58 IFNA1 IFNB1 IRF3
10
Show member pathways
12.63 BAX CASP3 CASP9 MAPK1
11
Show member pathways
12.54 CASP3 CASP9 IRF3 MAPK1
12 12.52 BAX CASP3 CASP9 IFNA1 KLK3 MAPK1
13
Show member pathways
12.46 DDX58 IFNA1 IFNB1 IRF3
14
Show member pathways
12.45 IFNA1 IFNB1 IRF3 MAPK1
15
Show member pathways
12.43 CASP3 IFNA1 IFNB1 MAPK1
16
Show member pathways
12.39 CASP3 CASP9 DDX58 IFNA1 IFNB1 IRF3
17 12.22 BAX CASP3 IRF3 MAPK1
18
Show member pathways
12.18 CD36 IFNB1 IRF3 MAPK1
19 12.17 BAX CASP3 CASP9
20
Show member pathways
12.16 BAX CASP3 CASP9 MAPK1
21
Show member pathways
12.14 BAX IFNA1 IFNB1
22
Show member pathways
12.13 BAX CASP3 CASP9 MAPK1
23 12.09 BAX CASP3 CASP9 MAPK1
24 12.08 IFNA1 IFNB1 IRF3
25
Show member pathways
12.08 IFNA1 IFNB1 IRF3
26
Show member pathways
12.07 BAX CASP9 MAPK1
27 12.04 BAX CASP3 CASP9 MAPK1
28
Show member pathways
12.02 BAX CASP3 CASP9 MAPK1
29
Show member pathways
11.97 CASP3 CASP9 MAPK1
30
Show member pathways
11.95 BAX CASP3 CASP9
31
Show member pathways
11.91 BAX CASP3 CASP9
32
Show member pathways
11.9 BAX CASP3 CASP9 MAPK1
33 11.86 CASP3 CASP9 MAPK1
34 11.84 BAX CASP3 MAPK1
35 11.84 DDX58 IFNA1 IFNB1 IRF3 MAPK1
36 11.8 CASP3 CASP9 MAPK1
37 11.79 BAX CASP3 CASP9
38 11.78 IFNA1 IFNB1 MAPK1
39
Show member pathways
11.74 BAX CASP3 CASP9
40
Show member pathways
11.74 BAX CASP3 CASP9 DDX58 IFNA1 IFNB1
41
Show member pathways
11.7 BAX CASP3 CASP9 MAPK1
42 11.69 CASP3 IRF3 MAPK1
43 11.69 BAX CASP3 CASP9 IFNA1 IFNB1 MAPK1
44
Show member pathways
11.68 BAX CASP3 CASP9 MAPK1
45 11.62 CASP3 CASP9 MAPK1
46 11.6 BAX CASP3 CASP9 MAPK1
47 11.42 BAX CASP3 CASP9
48
Show member pathways
11.36 BAX CASP9 MAPK1
49 11.34 CASP3 CASP9 MAPK1
50 11.29 CASP3 CASP9 IFNA1 IFNB1

GO Terms for Newcastle Disease

Biological processes related to Newcastle Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.95 BAX CASP3 CASP9 IRF3 MAPK1
2 viral process GO:0016032 9.91 BAX DDX58 IRF3 MAPK1
3 cellular response to DNA damage stimulus GO:0006974 9.85 BAX CASP3 CASP9 IRF3 MAPK1
4 response to lipopolysaccharide GO:0032496 9.73 CASP3 CASP9 IRF3 MAPK1
5 defense response to virus GO:0051607 9.71 DDX58 IFNA1 IFNB1 IRF3
6 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.69 BAX CASP3 CASP9
7 type I interferon signaling pathway GO:0060337 9.67 IFNA1 IFNB1 IRF3
8 regulation of type I interferon-mediated signaling pathway GO:0060338 9.62 IFNA1 IFNB1
9 positive regulation of interferon-beta production GO:0032728 9.61 DDX58 IRF3
10 T cell activation involved in immune response GO:0002286 9.6 IFNA1 IFNB1
11 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.59 IFNA1 IFNB1
12 B cell homeostasis GO:0001782 9.58 BAX CASP3
13 platelet formation GO:0030220 9.58 CASP3 CASP9
14 natural killer cell activation involved in immune response GO:0002323 9.57 IFNA1 IFNB1
15 cellular response to exogenous dsRNA GO:0071360 9.56 DDX58 IFNB1
16 positive regulation of interferon-alpha production GO:0032727 9.54 DDX58 IRF3
17 regulation of protein heterodimerization activity GO:0043497 9.52 BAX CD36
18 positive regulation of neuron apoptotic process GO:0043525 9.5 BAX CASP3 CASP9
19 response to cobalt ion GO:0032025 9.48 CASP3 CASP9
20 cellular response to organic substance GO:0071310 9.43 BAX CASP3 MAPK1
21 glial cell apoptotic process GO:0034349 9.37 CASP3 CASP9
22 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.33 BAX CASP3 CASP9
23 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.13 BAX CASP3 CASP9
24 response to exogenous dsRNA GO:0043330 9.02 DDX58 IFNA1 IFNB1 IRF3 MAPK1

Molecular functions related to Newcastle Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.16 IFNA1 IFNB1
2 type I interferon receptor binding GO:0005132 8.96 IFNA1 IFNB1
3 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 8.62 CASP3 CASP9

Sources for Newcastle Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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