MCID: NWC001
MIFTS: 53

Newcastle Disease malady

Summaries for Newcastle Disease

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A viral infectious disease that results in infection in birds and humans, has material basis in newcastle disease virus, which is transmitted by contact with feces and urine of an infected bird, or transmitted by fomites. the infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.

MalaCards: Newcastle Disease, also known as newcastle's disease, is related to adenocarcinoma and mumps, and has symptoms including headache, conjunctivitis and lacrimation in humans. An important gene associated with Newcastle Disease is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Type II interferon signaling (IFNG) and NF-kappaB Signaling. The compounds ribavirin and swainsonine have been mentioned in the context of this disorder. Affiliated tissues include tongue, brain and kidney, and related mouse phenotype cellular.

Wikipedia:64 Newcastle disease is a contagious bird disease affecting many domestic and wild avian species; it is... more...

Aliases & Classifications for Newcastle Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

newcastle disease 8 10 45 61
newcastle's disease 8
pseudo-fowlpest 8


External Ids:

Disease Ontology8 DOID:2929
MeSH35 D009521
NCIt40 C34849

Related Diseases for Newcastle Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Newcastle Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.2LGALS1, CXCL10, IRF1, IFNB1
2mumps30.0NEU1, IRF1
3rabies30.0MX1
4astrocytoma30.0IFNB1, IRF1, CXCL10
5measles30.0IFNB1, IRF1, LBR, MX1
6arthritis30.0MX1, CXCL10, IVNS1ABP, IRF1
7avian influenza10.8
8bronchitis10.5
9laryngotracheitis10.4
10lip disease10.4
11stomatitis10.3
12pinta disease10.2
13brain disease10.2
14marek disease10.2
15nipah virus disease10.2
16rift valley fever10.0
17renal clear cell carcinoma10.0
18tracheitis10.0
19eastern equine encephalitis10.0
20mu chain disease10.0
21n syndrome10.0
22phaeochromocytoma10.0
23squamous cell carcinoma10.0
24tongue disease10.0
25anaplastic astrocytoma10.0
26clear cell renal cell carcinoma10.0
27nipah virus encephalitis10.0
28m�ni�re disease10.0
29dengue hemorrhagic fever10.0IVNS1ABP
30cervical cancer10.0IRF1
31sarcoma10.0LGALS1
32cryoglobulinemic vasculitis10.0IFNA1
33lupus erythematosus10.0MX1
34severe acute respiratory syndrome10.0CXCL10, CTRL
35myelodysplastic syndromes10.0IRF1
36cryoglobulinemia10.0IFNA1
37biliary atresia10.0CXCL10, MX1
38malaria10.0NEU1
39lichen planus10.0MX1
40dermatomyositis10.0MX1
41multiple myeloma10.0CTRL
42hemophagocytic lymphohistiocytosis10.0MX1, IFNB1
43thrombocytopenia10.0IFNA1
44dengue disease10.0IVNS1ABP, NEU1, IFNB1
45acute leukemia10.0IRF1
46encephalitis10.0MX1, CXCL10, IFNA1
47thymoma10.0LBR, STK16
48subacute sclerosing panencephalitis10.0IFNA1, IRF1, MX1
49stomach cancer10.0IFNB1, IRF1, CTRL
50relapsing-remitting multiple sclerosis10.0MX1, IFNB1, IFNA1

Graphical network of the top 20 diseases related to Newcastle Disease:



Diseases related to newcastle disease

Clinical Features for Newcastle Disease

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 10)
  • headache
  • conjunctivitis
  • lacrimation in humans
  • gasping
  • coughing
  • twisting of head
  • circling
  • complete paralysis
  • watery diarrhea
  • reduced egg production in birds

Drugs & Therapeutics for Newcastle Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Newcastle Disease

Drug clinical trials:

Search ClinicalTrials for Newcastle Disease

Search NIH Clinical Center for Newcastle Disease

Search CenterWatch for Newcastle Disease

Genetic Tests for Newcastle Disease

Anatomical Context for Newcastle Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Newcastle Disease:

33
Tongue, Brain, Kidney, Lung, Whole blood, Breast, Prostate, Tonsil, Monocytes, T cells, B cells, Trachea

Animal Models for Newcastle Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Newcastle Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053849.6CXCL10, GRK1, IVNS1ABP, NEU1, DDX58, LBR

Publications for Newcastle Disease

Sources:
51PubMed
See all sources

Articles related to Newcastle Disease:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Recovery of avirulent, thermostable Newcastle disease virus strain NDV4-C from cloned cDNA and stable expression of an inserted foreign gene. (23657741)
2013
2
Complete genome sequence of a newcastle disease virus strain belonging to a recently identified genotype. (23405340)
2013
3
Comparative study on the pathogenesis of the generated 9a5b Newcastle disease virus mutant isolate between chickens and waterfowl. (23223199)
2013
4
A meta-analysis of observational epidemiological studies of Newcastle disease in African agro-systems, 1980-2009. (23228432)
2013
5
Immune responses of poultry to Newcastle disease virus. (23623955)
2013
6
Identification of a Genotype IX Newcastle Disease Virus in a Guangxi White Duck. (24115551)
2013
7
Phylogenetic characterization and virulence of two Newcastle disease viruses isolated from wild birds in China. (23999544)
2013
8
Mutations in the cytoplasmic domain of the Newcastle disease virus fusion protein confer hyperfusogenic phenotypes modulating viral replication and pathogenicity. (23843643)
2013
9
Mobilization of immunoglobulin (Ig)-containing plasma cells in Harderian gland, cecal tonsil and trachea of broilers vaccinated with Newcastle Disease Vaccine. (23395422)
2013
10
Characterization of Newcastle disease viruses isolated from cormorant and gull species in the United States in 2010. (22545538)
2012
11
Virulent Newcastle disease virus in Nigeria: identification of a new clade of sub-lineage 5f from livebird markets. (21960434)
2012
12
Importance of retinoic acid-inducible gene I and of receptor for type I interferon for cellular resistance to infection by Newcastle disease virus. (21971670)
2012
13
Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs. (22726244)
2012
14
Prevalence and incidence of Newcastle disease and prevalence of Avian Influenza infection of scavenging village chickens in Timor-LestAc. (22277596)
2012
15
Strategies of newcastle disease vaccination for commercial ostrich farms in Japan. (22301193)
2012
16
Adjuvanticity of compound polysaccharides on chickens against Newcastle disease and avian influenza vaccine. (22266329)
2012
17
Protection from clinical disease against three highly virulent strains of Newcastle disease virus after in ovo application of an antibody-antigen complex vaccine in maternal antibody-positive chickens. (23050473)
2012
18
Changes in fat metabolism of black-bone chickens during early stages of infection with Newcastle disease virus. (23217228)
2012
19
Exchange of Newcastle disease viruses in Korea: the relatedness of isolates between wild birds, live bird markets, poultry farms and neighboring countries. (22197764)
2012
20
Molecular epidemiologic investigation of lentogenic Newcastle disease virus from domestic birds at live bird markets in Korea. (22545549)
2012
21
Rescue of virulent class I Newcastle disease virus variant 9a5b-D5C1. (22709603)
2012
22
Hybrid- and complex-type N-glycans are not essential for Newcastle disease virus infection and fusion of host cells. (21964725)
2012
23
Impact of competitive non-protective antigens in a booster killed vaccine on seroconversions to protective antigens of Newcastle disease virus in chickens. (22194228)
2011
24
Enhancement of humoral immune responses to inactivated Newcastle disease and avian influenza vaccines by oral administration of ginseng stem-and-leaf saponins in chickens. (21844260)
2011
25
Genotypic and pathotypic characterization of Newcastle disease viruses from India. (22174801)
2011
26
Molecular characterization of a virulent genotype VIId strain of Newcastle disease virus from farmed chickens in Shanghai. (21793446)
2011
27
The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein. (21270151)
2011
28
Epitope variation in the Newcastle disease virus HN gene under antibody immune selective pressure in cell culture. (21455691)
2011
29
Coexpression of avian influenza virus H5 and N1 by recombinant Newcastle disease virus and the impact on immune response in chickens. (22017039)
2011
30
Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk. (21873198)
2011
31
Avian influenza virus and Newcastle disease virus (NDV) surveillance in commercial breeding farm in China and the characterization of Class I NDV isolates. (20133090)
2010
32
Inhibition of host innate immune responses and pathogenicity of recombinant Newcastle disease viruses expressing NS1 genes of influenza A viruses. (20410312)
2010
33
Newcastle disease virus infection promotes Bax redistribution to mitochondria and cell death in HeLa cells. (19955813)
2010
34
Evolutionary changes affecting rapid identification of 2008 Newcastle disease viruses isolated from double-crested cormorants. (20107098)
2010
35
Newcastle disease virus in penguins from King George Island on the Antarctic region. (20570062)
2010
36
The anti-tumor effect of Newcastle disease virus HN protein is influenced by differential subcellular targeting. (20130861)
2010
37
The oncolytic activity of Newcastle disease virus NDV-HUJ on chemoresistant primary melanoma cells is dependent on the proapoptotic activity of the inhibitor of apoptosis protein Livin. (19864394)
2010
38
Detection and differentiation of velogenic and lentogenic Newcastle disease viruses using SYBR Green I real-time PCR with nucleocapsid gene-specific primers. (19447142)
2009
39
An improved reverse transcription loop-mediated isothermal amplification assay for sensitive and specific detection of Newcastle disease virus. (19649763)
2009
40
Vaccination of chickens using raw rice coated with novel trehalose nano-organogels containing Newcastle disease (strain I-2) vaccine. (19015948)
2009
41
Role of thiol/disulfide exchange in newcastle disease virus entry. (18922867)
2009
42
Development of a real-time reverse-transcription PCR for the detection and simultaneous pathotyping of Newcastle disease virus isolates using a novel probe. (19444547)
2009
43
A vaccine candidate of attenuated genotype VII Newcastle disease virus generated by reverse genetics. (19095026)
2009
44
Construction, expression and immunoassay detection of recombinant plasmid encoding fusion protein of Roman chicken complement C3d and Newcastle disease virus F gene. (19055698)
2008
45
Selective oncolytic effect of an attenuated Newcastle disease virus (NDV-HUJ) in lung tumors. (18535620)
2008
46
Biological and phylogenetic characterization of virulent Newcastle disease virus circulating in Mexico. (18939638)
2008
47
Recombinant Newcastle disease virus expressing human interleukin-2 serves as a potential candidate for tumor therapy. (18538434)
2008
48
Structural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle disease virus. (16575531)
2006
49
TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus. (12574346)
2003
50
A mucoprotein derived from human urine which reacts with influenza, mumps, and Newcastle disease viruses. (14907962)
1952

Genetic Variations for Newcastle Disease

Expression for genes affiliated with Newcastle Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Newcastle Disease

Search GEO for disease gene expression data for Newcastle Disease.

Pathways for genes affiliated with Newcastle Disease

Sources:
38NCBI BioSystems Database, 4Cell Signaling Technology, 54Reactome, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Newcastle Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IFNB1, IRF1, CXCL10
210.2DDX58, IRF1, IRF3
3
Hide members
10.2BIRC7, IRF1, IRF3
4
Hide members
10.1IRF3, IFNB1, IFNA1
5
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
10.1IFNA1, IFNB1, IRF3
6
Hide members
10.0DDX58, IRF3, IFNB1, IFNA1
7
Immune response IFN alpha/beta signaling pathway
Hide members
10.0MX1, IRF1, IRF3, IFNB1, IFNA1
810.0IFNA1, IFNB1, IRF3, IRF1, DDX58
9
Hide members
10.0IFNA1, IFNB1, IRF3, DDX58, CXCL10
10
Hide members
10.0IFNA1, IFNB1, IRF3, DDX58, CXCL10
11
Hide members
9.9IFNA1, IFNB1, IRF3, IRF1, DDX58, MX1
12
Hide members
9.8IFNA1, IFNB1, IRF3, DDX58, IVNS1ABP, CXCL10
13
Hide members
9.6IFNA1, IFNB1, IRF3, IRF1, DDX58, DDX58

Compounds for genes affiliated with Newcastle Disease

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Newcastle Disease according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1ribavirin45 50 1112.7MX1, NEU1, LBR
2swainsonine45 1111.6NEU1, LGALS1
3gal(beta1-3)galnac4510.6NEU1, LGALS1
4rebif4510.6MX1, IFNB1, IFNA1
5avonex4510.6IFNA1, IFNB1, MX1
6acyclovir45 1111.6IFNA1, IFNB1, NEU1
7betaseron4510.6MX1, IFNB1, IFNA1
8con a4510.6LBR, NEU1, LGALS1
9indoleamine4510.6IRF1, IFNB1, IFNA1
10phytate4510.5GRK1, IFNB1
11imiquimod45 29 60 1113.5IFNA1, IFNB1, MX1
12n-acetyllactosamine45 2411.5LGALS7, LGALS1, NEU1
13ccl345 2911.5CXCL10, IFNB1, IFNA1
14mezerein4510.5IFNB1, IFNA1
15zidovudine45 1111.5NEU1, LBR, IFNB1, IFNA1
16kynurenine4510.5IFNB1, IFNA1
17inosine monophosphate4510.5IFNA1, IFNB1, IRF3, IRF1
18chloroquine45 2 50 29 1114.5CXCL10, IFNB1, IFNA1
19polyacrylamide4510.4LGALS1, GRK1, NEU1, CTRL
20amantadine45 1111.4IFNA1, NEU1
21cycloheximide4510.4IFNA1, IFNB1, IRF1, CXCL10, MX1
222,5-oligoadenylate4510.4IFNA1, IFNB1, IRF1, CXCL10, MX1
23rantes4510.4IFNA1, IFNB1, IRF3, IRF1, LBR
24neopterin4510.4IFNA1, IFNB1, LBR, CXCL10, MX1
25chloramphenicol45 2 1112.4IFNB1, IRF3, IRF1, LBR, MX1
26polylactosamine4510.4NEU1, LGALS1
27galactose4510.4NEU1, LGALS1, LGALS7
28purine45 2411.4IFNB1, LBR, GRK1
29tamoxifen45 50 29 1113.4IFNA1, IFNB1, IRF1, CTRL
30retinoid4510.4IFNA1, IFNB1, IRF1, LGALS1
31thymidine45 2411.3IFNA1, IFNB1, IRF1, LBR, CXCL10
32serine4510.3IRF1, CTRL, NEU1, GRK1, BIRC7, MX1
33etoposide45 50 60 1113.3IFNA1, IFNB1, IRF1, BIRC7, LGALS1
34polyinosinic-polycytidylic acid4510.3IFNA1, IFNB1, IRF3, IRF1, DDX58, CXCL10
35ifn-alpha4510.3IFNA1, IFNB1, IRF3, IRF1, CXCL10, MX1
36heparin45 29 11 2413.3IFNB1, CTRL, LBR, NEU1, LGALS1
37histamine45 29 2412.3CXCL10, NEU1, LBR, CTRL
38zinc45 2411.3IFNB1, IRF3, IRF1, CTRL, LBR, GRK1
39glatiramer acetate45 1111.3IFNB1, IFNA1
40nucleoside4510.2IFNA1, IFNB1, GRK1
41poly(i-c)4510.2MX1, IFNA1, IFNB1, IRF3, IRF1, DDX58
42monosaccharide4510.2NEU1, LGALS1
43lipid4510.2IFNB1, IRF3, IRF1, LBR, CXCL10, MX1
44dexamethasone45 50 29 1113.1LGALS1, LBR, IFNB1, IFNA1
45tyrosine4510.0IFNA1, IFNB1, IRF3, IRF1, CTRL, LBR
46didanosine45 1111.0IFNA1, LBR
47retinoic acid45 2410.9IFNA1, IFNB1, IRF3, IRF1, CTRL, LBR

GO Terms for genes affiliated with Newcastle Disease

Sources:
16Gene Ontology
See all sources

Biological processes related to Newcastle Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to exogenous dsRNAGO:04333010.3DDX58, IRF3
2positive regulation of interferon-beta productionGO:03272810.3IRF3, IRF1, DDX58
3type I interferon-mediated signaling pathwayGO:06033710.2MX1, IRF1, IRF3, IFNB1
4positive regulation of interferon-alpha productionGO:03272710.2DDX58, IRF3
5defense response to virusGO:05160710.1IFNB1, IRF3, IRF1, CXCL10, MX1
6response to virusGO:00961510.1MX1, IVNS1ABP, DDX58, IFNB1, CCDC130
7cytokine-mediated signaling pathwayGO:01922110.1MX1, IRF1, IRF3, IFNB1
8apoptotic processGO:0069159.7IRF3, IRF1, GRK1, MX1, LGALS1

Products for genes affiliated with Newcastle Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Newcastle Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet