MCID: NWC001
MIFTS: 54

Newcastle Disease malady

Summaries for Newcastle Disease

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection in birds and humans, has material basis in newcastle disease virus, which is transmitted by contact with feces and urine of an infected bird, or transmitted by fomites. the infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.

MalaCards: Newcastle Disease, also known as newcastle's disease, is related to influenza and encephalitis, and has symptoms including headache, lacrimation in humans and gasping. An important gene associated with Newcastle Disease is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Type II interferon signaling (IFNG) and NF-kappaB Signaling. The compounds ribavirin and swainsonine have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related mouse phenotype cellular.

Wikipedia:63 Newcastle disease is a contagious bird disease affecting many domestic and wild avian species; it is... more...

Aliases & Classifications for Newcastle Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

newcastle disease 8 10 44 60
newcastle's disease 8
pseudo-fowlpest 8


External Ids:

Disease Ontology8 DOID:2929
MeSH34 D009521
NCIt39 C34849

Related Diseases for Newcastle Disease

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17GeneCards, 18GeneDecks
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Diseases related to Newcastle Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1influenza31.2MX1, CXCL10, IFNA1, IFNB1, IRF3, IRF1
2encephalitis30.3CXCL10, IFNA1, MX1
3prostate cancer30.2MX1, LGALS1, CXCL10, CTRL
4lung cancer30.2LGALS1, LBR, IRF1, IRF3, IFNB1, BIRC7
5adenocarcinoma30.2LGALS1, IFNB1, CXCL10, IRF1
6melanoma30.1IFNA1, MX1, LGALS1, BIRC7, LBR, IRF1
7mumps29.9NEU1, IRF1
8rabies29.9MX1
9astrocytoma29.9CXCL10, IRF1, IFNB1
10measles29.9MX1, IFNB1, LBR, IRF1
11arthritis29.9MX1, CXCL10, IRF1, IVNS1ABP
12hepatitis29.9IFNB1, IFNA1, CXCL10
13hepatocellular carcinoma29.9IFNB1, LGALS1, IRF1, NEU1, IFNA1
14leukemia29.9IRF1, IFNA1, CTRL, LGALS1, LBR, IFNB1
15avian influenza10.8
16bronchitis10.4
17laryngotracheitis10.4
18pancreatitis10.3
19coats disease10.2
20stomatitis10.2
21brain disease10.1
22peritonitis10.1
23prostate disease10.1
24prostatitis10.1
25dengue hemorrhagic fever10.0IVNS1ABP
26cervical cancer10.0IRF1
27sarcoma10.0LGALS1
28cryoglobulinemic vasculitis10.0IFNA1
29lupus erythematosus10.0MX1
30severe acute respiratory syndrome10.0CXCL10, CTRL
31myelodysplastic syndromes10.0IRF1
32cryoglobulinemia10.0IFNA1
33biliary atresia10.0CXCL10, MX1
34malaria10.0NEU1
35dermatomyositis10.0MX1
36lichen planus10.0MX1
37multiple myeloma10.0CTRL
38hemophagocytic lymphohistiocytosis10.0IFNB1, MX1
39thrombocytopenia10.0IFNA1
40dengue disease10.0IFNB1, IVNS1ABP, NEU1
41acute leukemia10.0IRF1
42thymoma10.0STK16, LBR
43subacute sclerosing panencephalitis10.0IRF1, IFNA1, MX1
44stomach cancer10.0IRF1, CTRL, IFNB1
45relapsing-remitting multiple sclerosis10.0MX1, IFNB1, IFNA1
46kaposi's sarcoma10.0IFNB1, IFNA1, CXCL10, LBR
47psoriasis10.0CXCL10, IRF1, MX1
48dermatitis10.0CXCL10
49hepatitis b10.0IFNA1, MX1, CXCL10
50encephalomyelitis10.0CXCL10, IFNB1

Graphical network of the top 20 diseases related to Newcastle Disease:



Diseases related to newcastle disease

Clinical Features for Newcastle Disease

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8Disease Ontology
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Symptoms:

8 (show all 10)
  • headache
  • lacrimation in humans
  • gasping
  • coughing
  • twisting of head
  • circling
  • complete paralysis
  • watery diarrhea
  • reduced egg production in birds
  • conjunctivitis

Drugs & Therapeutics for Newcastle Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Newcastle Disease

Drug clinical trials:

Search ClinicalTrials for Newcastle Disease

Search NIH Clinical Center for Newcastle Disease

Search CenterWatch for Newcastle Disease

Genetic Tests for Newcastle Disease

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Anatomical Context for Newcastle Disease

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32MalaCards
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MalaCards organs/tissues related to Newcastle Disease:

32
Lung, T cells, Testes, Prostate, Brain, Tonsil, Monocytes, Breast, Tongue, Kidney, Trachea, Bone

Animal Models for Newcastle Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Newcastle Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053849.6CXCL10, GRK1, IVNS1ABP, NEU1, DDX58, LBR

Publications for Newcastle Disease

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50PubMed
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Articles related to Newcastle Disease:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Alteration in lymphocyte responses, cytokine and chemokine profiles in chickens infected with genotype VII and VIII velogenic Newcastle disease virus. (24225159)
2014
2
Recombinant infectious bursal disease virus expressing Newcastle disease virus (NDV) neutralizing epitope confers partial protection against virulent NDV challenge in chickens. (24200519)
2014
3
Molecular epidemiology of Newcastle disease viruses in Vietnam. (24061688)
2014
4
Complete genome sequences of new emerging newcastle disease virus strains isolated from china. (23469337)
2013
5
Evaluation of the U.S. Department of Agriculture's egg pasteurization processes on the inactivation of high-pathogenicity avian influenza virus and velogenic Newcastle disease virus in processed egg products. (23575126)
2013
6
Application of green fluorescent protein-labeled assay for the study of subcellular localization of Newcastle disease virus matrix protein. (23994149)
2013
7
'a'-Position-mutated and G4-mutated hemagglutinin-neuraminidase proteins of Newcastle disease virus impair fusion and hemagglutinin-neuraminidase-fusion interaction by different mechanisms. (23038058)
2013
8
Newcastle disease: progress and gaps in the development of vaccines and diagnostic tools. (23689887)
2013
9
Detection and molecular characterization of Newcastle disease virus in peafowl (Pavo cristatus) in Haryana State, India. (24426301)
2013
10
Biological and phylogenetic characterization of a genotype VII Newcastle disease virus from Venezuela: efficacy of field vaccination. (22238433)
2012
11
The role of zinc on anti-Newcastle disease virus specific antibody response and agranulocytes count in rabbits treated with methotrexate and prednisolone. (23010003)
2012
12
Preparation and efficacy of a live newcastle disease virus vaccine encapsulated in chitosan nanoparticles. (23285276)
2012
13
Complete genome sequence of Newcastle disease virus mesogenic vaccine strain R2B from India. (23166233)
2012
14
Whole genome sequencing and biological characterization of Duck/JS/10, a new lentogenic class I Newcastle disease virus. (22310996)
2012
15
Isolation of Newcastle disease virus from a non-avian host (sheep) and its implications. (22543636)
2012
16
Situation of serum antibodies against Newcastle disease virus in slaughter-age ostriches after vaccination campaign in Japan. (22075709)
2012
17
The long view: a selective review of 40 years of Newcastle disease research. (22834545)
2012
18
Complete genome and clinicopathological characterization of a virulent Newcastle disease virus isolate from South America. (22135263)
2012
19
Virulent Newcastle disease virus elicits a strong innate immune response in chickens. (21177922)
2011
20
Analysis of the Fusion Protein Cleavage Site of Newcastle disease virus Isolates from India Reveals Preliminary Evidence for the Existence of II, VI and VII Genotypes. (23637515)
2011
21
Effect of oral administration of ginseng stem-and-leaf saponins (GSLS) on the immune responses to Newcastle disease vaccine in chickens. (21569814)
2011
22
Influence of insertion site of the avian influenza virus haemagglutinin (HA) gene within the Newcastle disease virus genome on HA expression. (21068215)
2011
23
Measures of psoriatic arthritis: Tender and Swollen Joint Assessment, Psoriasis Area and Severity Index (PASI), Nail Psoriasis Severity Index (NAPSI), Modified Nail Psoriasis Severity Index (mNAPSI), Mander/Newcastle Enthesitis Index (MEI), Leeds Enthesitis Index (LEI), Spondyloarthritis Research Consortium of Canada (SPARCC), Maastricht Ankylosing Spondylitis Enthesis Score (MASES), Leeds Dactylitis Index (LDI), Patient Global for Psoriatic Arthritis, Dermatology Life Quality Index (DLQI), Psoriatic Arthritis Quality of Life (PsAQOL), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), Psoriatic Arthritis Response Criteria (PsARC), Psoriatic Arthritis Joint Activity Index (PsAJAI), Disease Activity in Psoriatic Arthritis (DAPSA), and Composite Psoriatic Disease Activity Index (CPDAI). (22588772)
2011
24
Oncolytic specificity of Newcastle disease virus is mediated by selectivity for apoptosis-resistant cells. (21471241)
2011
25
Newcastle disease in the European Union 2000 to 2009. (22107088)
2011
26
The combined effects of oncolytic reovirus plus Newcastle disease virus and reovirus plus parvovirus on U87 and U373 cells inA vitro and inA vivo. (21607667)
2011
27
Important role of interferon regulatory factor (IRF)-3 in the interferon response of mouse macrophages upon infection by Newcastle disease virus. (21567079)
2011
28
Induction of type I interferon secretion through recombinant Newcastle disease virus expressing measles virus hemagglutinin stimulates antibody secretion in the presence of maternal antibodies. (20962092)
2011
29
Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence. (20965986)
2011
30
Molecular characterization of Newcastle disease viruses in Ostriches (Struthio camelus L.): further evidences of recombination within avian paramyxovirus type 1. (21215532)
2011
31
Positive selection in the hemagglutinin-neuraminidase gene of Newcastle disease virus and its effect on vaccine efficacy. (21453506)
2011
32
Parenteral vaccination of mammalian livestock with Newcastle disease virus-based vector vaccines offers optimal efficacy and safety. (21636990)
2011
33
Analysis of codon usage in Newcastle disease virus. (21249440)
2011
34
Selective isolation of Avian influenza virus (AIV) from cloacal samples containing AIV and Newcastle disease virus. (21398457)
2011
35
Surveillance and characterization of Newcastle disease viruses isolated from northern pintail (Anas acuta) in Japan during 2006-09. (21793438)
2011
36
Newcastle disease virus in Madagascar: identification of an original genotype possibly deriving from a died out ancestor of genotype IV. (21085573)
2010
37
The hemagglutinin-neuraminidase gene of Newcastle Disease Virus: a powerful molecular adjuvant for DNA anti-tumor vaccination. (20709006)
2010
38
Genomic characterization of the first class I Newcastle disease virus isolated from the mainland of China. (20146094)
2010
39
Immunogenicity and protective efficacy of virosome based vaccines against Newcastle disease. (19728133)
2010
40
The housefly, Musca domestica, as a possible mechanical vector of Newcastle disease virus in the laboratory and field. (20377736)
2010
41
Evidence for a role of mast cells in the mucosal injury induced by Newcastle disease virus. (19211524)
2009
42
Expression of Newcastle disease virus (NDV) M protein from a recombinant plasmid prolongs the survival of NDV-infected chicken embryos and enhances the virus replication. (19537911)
2009
43
Cross-infection of tumor cells by contact with T lymphocytes loaded with Newcastle disease virus. (19287952)
2009
44
A Y526Q mutation in the Newcastle disease virus HN protein reduces its functional activities and attenuates virus replication and pathogenicity. (19474107)
2009
45
Characterization of a recombinant Newcastle disease virus vaccine strain. (18768673)
2008
46
Monitoring of wild birds for Newcastle disease virus in Switzerland using real time RT-PCR. (18689670)
2008
47
Protective efficacy of commercial inactivated Newcastle disease virus vaccines in chickens against a recent Korean epizootic strain. (18716450)
2008
48
Protection of chickens from Newcastle disease and infectious laryngotracheitis with a recombinant fowlpox virus co-expressing the F, HN genes of Newcastle disease virus and gB gene of infectious laryngotracheitis virus. (18459306)
2008
49
Inhibition of parainfluenza virus type 3 and Newcastle disease virus hemagglutinin-neuraminidase receptor binding: effect of receptor avidity and steric hindrance at the inhibitor binding sites. (15564499)
2004
50
Experimental infections of wild birds with the viruses of eastern equine encephalitis, Newcastle disease and vesicular stomatitis. (14404590)
1959

Genetic Variations for Newcastle Disease

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Expression for genes affiliated with Newcastle Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Newcastle Disease

Search GEO for disease gene expression data for Newcastle Disease.

Pathways for genes affiliated with Newcastle Disease

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Sources:
37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 29KEGG, 12EMD Millipore
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Pathways related to Newcastle Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IFNB1, IRF1, CXCL10
210.2DDX58, IRF1, IRF3
3
Hide members
10.2BIRC7, IRF1, IRF3
4
Hide members
10.1IRF3, IFNB1, IFNA1
5
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
10.1IFNA1, IFNB1, IRF3
6
Hide members
10.0DDX58, IRF3, IFNB1, IFNA1
7
Immune response IFN alpha/beta signaling pathway
Hide members
10.0MX1, IRF1, IRF3, IFNB1, IFNA1
810.0IFNA1, IFNB1, IRF3, IRF1, DDX58
9
Hide members
10.0IFNA1, IFNB1, IRF3, DDX58, CXCL10
10
Hide members
10.0IFNA1, IFNB1, IRF3, DDX58, CXCL10
11
Hide members
9.9IFNA1, IFNB1, IRF3, IRF1, DDX58, MX1
12
Hide members
9.8IFNA1, IFNB1, IRF3, DDX58, IVNS1ABP, CXCL10
13
Hide members
9.6IFNA1, IFNB1, IRF3, IRF1, DDX58, DDX58

Compounds for genes affiliated with Newcastle Disease

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Newcastle Disease according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1ribavirin44 49 1112.7MX1, NEU1, LBR
2swainsonine44 1111.6NEU1, LGALS1
3gal(beta1-3)galnac4410.6NEU1, LGALS1
4rebif4410.6MX1, IFNB1, IFNA1
5avonex4410.6IFNA1, IFNB1, MX1
6acyclovir44 1111.6IFNA1, IFNB1, NEU1
7betaseron4410.6MX1, IFNB1, IFNA1
8con a4410.6LBR, NEU1, LGALS1
9indoleamine4410.6IRF1, IFNB1, IFNA1
10phytate4410.5GRK1, IFNB1
11imiquimod44 28 59 1113.5IFNA1, IFNB1, MX1
12n-acetyllactosamine44 2411.5LGALS7, LGALS1, NEU1
13ccl344 2811.5CXCL10, IFNB1, IFNA1
14mezerein4410.5IFNB1, IFNA1
15zidovudine44 1111.5NEU1, LBR, IFNB1, IFNA1
16kynurenine4410.5IFNB1, IFNA1
17inosine monophosphate4410.5IFNA1, IFNB1, IRF3, IRF1
18chloroquine44 2 49 28 1114.5CXCL10, IFNB1, IFNA1
19polyacrylamide4410.4LGALS1, GRK1, NEU1, CTRL
20amantadine44 1111.4IFNA1, NEU1
21cycloheximide4410.4IFNA1, IFNB1, IRF1, CXCL10, MX1
222,5-oligoadenylate4410.4IFNA1, IFNB1, IRF1, CXCL10, MX1
23rantes4410.4IFNA1, IFNB1, IRF3, IRF1, LBR
24neopterin4410.4IFNA1, IFNB1, LBR, CXCL10, MX1
25chloramphenicol44 2 1112.4IFNB1, IRF3, IRF1, LBR, MX1
26polylactosamine4410.4NEU1, LGALS1
27galactose4410.4NEU1, LGALS1, LGALS7
28purine44 2411.4IFNB1, LBR, GRK1
29tamoxifen44 49 28 1113.4IFNA1, IFNB1, IRF1, CTRL
30retinoid4410.4IFNA1, IFNB1, IRF1, LGALS1
31thymidine44 2411.3IFNA1, IFNB1, IRF1, LBR, CXCL10
32serine4410.3IRF1, CTRL, NEU1, GRK1, BIRC7, MX1
33etoposide44 49 59 1113.3IFNA1, IFNB1, IRF1, BIRC7, LGALS1
34polyinosinic-polycytidylic acid4410.3IFNA1, IFNB1, IRF3, IRF1, DDX58, CXCL10
35ifn-alpha4410.3IFNA1, IFNB1, IRF3, IRF1, CXCL10, MX1
36heparin44 28 11 2413.3IFNB1, CTRL, LBR, NEU1, LGALS1
37histamine44 28 2412.3CXCL10, NEU1, LBR, CTRL
38zinc44 2411.3IFNB1, IRF3, IRF1, CTRL, LBR, GRK1
39glatiramer acetate44 1111.3IFNB1, IFNA1
40nucleoside4410.2IFNA1, IFNB1, GRK1
41poly(i-c)4410.2MX1, IFNA1, IFNB1, IRF3, IRF1, DDX58
42monosaccharide4410.2NEU1, LGALS1
43lipid4410.2IFNB1, IRF3, IRF1, LBR, CXCL10, MX1
44dexamethasone44 49 28 1113.1LGALS1, LBR, IFNB1, IFNA1
45tyrosine4410.0IFNA1, IFNB1, IRF3, IRF1, CTRL, LBR
46didanosine44 1111.0IFNA1, LBR
47retinoic acid44 2410.9IFNA1, IFNB1, IRF3, IRF1, CTRL, LBR

GO Terms for genes affiliated with Newcastle Disease

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16Gene Ontology
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Biological processes related to Newcastle Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to exogenous dsRNAGO:04333010.3DDX58, IRF3
2positive regulation of interferon-beta productionGO:03272810.3IRF3, IRF1, DDX58
3type I interferon-mediated signaling pathwayGO:06033710.2MX1, IRF1, IRF3, IFNB1
4positive regulation of interferon-alpha productionGO:03272710.2DDX58, IRF3
5defense response to virusGO:05160710.1IFNB1, IRF3, IRF1, CXCL10, MX1
6response to virusGO:00961510.1MX1, IVNS1ABP, DDX58, IFNB1, CCDC130
7cytokine-mediated signaling pathwayGO:01922110.1MX1, IRF1, IRF3, IFNB1
8apoptotic processGO:0069159.7IRF3, IRF1, GRK1, MX1, LGALS1

Products for genes affiliated with Newcastle Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Newcastle Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet