MCID: NWC001
MIFTS: 54

Newcastle Disease malady

Summaries for Newcastle Disease

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A viral infectious disease that results in infection in birds and humans, has material basis in newcastle disease virus, which is transmitted by contact with feces and urine of an infected bird, or transmitted by fomites. the infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.

MalaCards: Newcastle Disease, also known as newcastle's disease, is related to influenza and encephalitis, and has symptoms including headache, lacrimation in humans and gasping. An important gene associated with Newcastle Disease is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Type II interferon signaling (IFNG) and NF-kappaB Signaling. The compounds ribavirin and swainsonine have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related mouse phenotype cellular.

Wikipedia:63 Newcastle disease is a contagious bird disease affecting many domestic and wild avian species; it is... more...

Aliases & Classifications for Newcastle Disease

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
See all sources

Aliases & Descriptions:

newcastle disease 8 10 44 60
newcastle's disease 8
pseudo-fowlpest 8


External Ids:

Disease Ontology8 DOID:2929
MeSH34 D009521
NCIt39 C34849

Related Diseases for Newcastle Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Newcastle Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1influenza31.2MX1, CXCL10, IFNA1, IFNB1, IRF3, IRF1
2encephalitis30.3CXCL10, IFNA1, MX1
3prostate cancer30.2MX1, LGALS1, CXCL10, CTRL
4lung cancer30.2LGALS1, LBR, IRF1, IRF3, IFNB1, BIRC7
5adenocarcinoma30.2LGALS1, IFNB1, CXCL10, IRF1
6melanoma30.1IFNA1, MX1, LGALS1, BIRC7, LBR, IRF1
7mumps29.9NEU1, IRF1
8rabies29.9MX1
9astrocytoma29.9CXCL10, IRF1, IFNB1
10measles29.9MX1, IFNB1, LBR, IRF1
11arthritis29.9MX1, CXCL10, IRF1, IVNS1ABP
12hepatitis29.9IFNB1, IFNA1, CXCL10
13hepatocellular carcinoma29.9IFNB1, LGALS1, IRF1, NEU1, IFNA1
14leukemia29.9IRF1, IFNA1, CTRL, LGALS1, LBR, IFNB1
15avian influenza10.8
16bronchitis10.4
17laryngotracheitis10.4
18pancreatitis10.3
19coats disease10.2
20stomatitis10.2
21brain disease10.1
22peritonitis10.1
23prostate disease10.1
24prostatitis10.1
25dengue hemorrhagic fever10.0IVNS1ABP
26cervical cancer10.0IRF1
27sarcoma10.0LGALS1
28cryoglobulinemic vasculitis10.0IFNA1
29lupus erythematosus10.0MX1
30severe acute respiratory syndrome10.0CXCL10, CTRL
31myelodysplastic syndromes10.0IRF1
32cryoglobulinemia10.0IFNA1
33biliary atresia10.0CXCL10, MX1
34malaria10.0NEU1
35dermatomyositis10.0MX1
36lichen planus10.0MX1
37multiple myeloma10.0CTRL
38hemophagocytic lymphohistiocytosis10.0IFNB1, MX1
39thrombocytopenia10.0IFNA1
40dengue disease10.0IFNB1, IVNS1ABP, NEU1
41acute leukemia10.0IRF1
42thymoma10.0STK16, LBR
43subacute sclerosing panencephalitis10.0IRF1, IFNA1, MX1
44stomach cancer10.0IRF1, CTRL, IFNB1
45relapsing-remitting multiple sclerosis10.0MX1, IFNB1, IFNA1
46kaposi's sarcoma10.0IFNB1, IFNA1, CXCL10, LBR
47psoriasis10.0CXCL10, IRF1, MX1
48dermatitis10.0CXCL10
49hepatitis b10.0IFNA1, MX1, CXCL10
50encephalomyelitis10.0CXCL10, IFNB1

Graphical network of the top 20 diseases related to Newcastle Disease:



Diseases related to newcastle disease

Clinical Features for Newcastle Disease

About this section
Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 10)
  • headache
  • lacrimation in humans
  • gasping
  • coughing
  • twisting of head
  • circling
  • complete paralysis
  • watery diarrhea
  • reduced egg production in birds
  • conjunctivitis

Drugs & Therapeutics for Newcastle Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Newcastle Disease

Drug clinical trials:

Search ClinicalTrials for Newcastle Disease

Search NIH Clinical Center for Newcastle Disease

Search CenterWatch for Newcastle Disease

Genetic Tests for Newcastle Disease

About this section

Anatomical Context for Newcastle Disease

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Newcastle Disease:

32
Lung, T cells, Testes, Prostate, Brain, Tonsil, Monocytes, Breast, Tongue, Kidney, Trachea, Bone

Animal Models for Newcastle Disease or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Newcastle Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053849.6CXCL10, GRK1, IVNS1ABP, NEU1, DDX58, LBR

Publications for Newcastle Disease

About this section
Sources:
50PubMed
See all sources

Articles related to Newcastle Disease:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Autophagy benefits the replication of newcastle disease virus in chicken cells and tissues. (24173218)
2014
2
Prime-boost vaccination with recombinant H5-fowlpox and Newcastle disease virus vectors affords lasting protection in SPF Muscovy ducks against highly pathogenic H5N1 influenza virus. (23845804)
2013
3
Pathogenesis of Newcastle Disease in Vaccinated Chickens: Pathogenicity of Isolated Virus and Vaccine Effect on Challenge of Its Virus. (23966012)
2013
4
Multiplex nested RT-PCR for detecting avian influenza virus, infectious bronchitis virus and Newcastle disease virus. (23261801)
2013
5
Complete genome sequence of a highly virulent newcastle disease virus currently circulating in Mexico. (23409252)
2013
6
Genetically engineered Newcastle disease virus for prostate cancer: a magic bullet or a misfit. (23875655)
2013
7
Scutellaria polysaccharide inhibits the infectivity of Newcastle disease virus to chicken embryo fibroblast. (24122783)
2013
8
The immunological adjuvant activity of gypenosides liposome against Newcastle disease vaccine. (23732326)
2013
9
Immunization with a Thermostable Newcastle Disease Virus K148/08 Strain Originated from Wild Mallard Duck Confers Protection against Lethal Viscerotropic Velogenic Newcastle Disease Virus Infection in Chickens. (24358260)
2013
10
Biological characterization and phylogenetic analysis of a novel genetic group of Newcastle disease virus isolated from outbreaks in commercial poultry and from backyard poultry flocks in Pakistan. (22418457)
2012
11
Surveillance for avian influenza and Newcastle disease in backyard poultry flocks in CA'te d'Ivoire, 2007-2009. (23520736)
2012
12
Lack of detection of host associated differences in Newcastle disease viruses of genotype VIId isolated from chickens and geese. (22971647)
2012
13
Immune responses and protection against H5N1 highly pathogenic avian influenza virus induced by the Newcastle disease virus H5 vaccine in ducks. (23402116)
2012
14
Newcastle disease virus outbreaks: vaccine mismatch or inadequate application? (22655976)
2012
15
Development of a novel real-time PCR-based strategy for simple and rapid molecular pathotyping of Newcastle disease virus. (22302287)
2012
16
Advancement in vaccination against Newcastle disease: recombinant HVT NDV provides high clinical protection and reduces challenge virus shedding with the absence of vaccine reactions. (22856183)
2012
17
Complete genome sequences of Newcastle disease virus strains circulating in chicken populations of Indonesia. (22532534)
2012
18
Reduced Newcastle disease virus-induced oncolysis in a subpopulation of cisplatin-resistant MCF7 cells is associated with survivin stabilization. (22853623)
2012
19
Velogenic newcastle disease virus as an oncolytic virotherapeutics: in vitro characterization. (22644640)
2012
20
Apoptin enhances the oncolytic properties of Newcastle disease virus. (21865658)
2012
21
Antiviral activity of crude extracts from Commiphora swynnertonii against Newcastle disease virus in ovo. (22302704)
2012
22
Extracellular matrix constituents interfere with Newcastle disease virus spread in solid tissue and diminish its potential oncolytic activity. (22622327)
2012
23
Analysis of three properties of Newcastle disease virus for fighting cancer: tumor-selective replication, antitumor cytotoxicity, and immunostimulation. (21948477)
2012
24
Sequence analysis of fusion protein gene of Newcastle disease virus isolated from outbreaks in Egypt during 2006. (21592379)
2011
25
Formulation of novel nano-encapsulated Newcastle disease vaccine tablets for vaccination of village chickens. (20683657)
2011
26
Immunological adjuvant efficacy of glycyrrhetinic acid liposome against Newcastle disease vaccine. (22044741)
2011
27
Multiplex RT-PCR for rapid detection and differentiation of class I and class II Newcastle disease viruses. (21034772)
2011
28
Systematic selection of housekeeping genes for gene expression normalization in chicken embryo fibroblasts infected with Newcastle disease virus. (21925148)
2011
29
Generation of a genotype VII Newcastle disease virus vaccine candidate with high yield in embryonated chicken eggs. (22017036)
2011
30
Potentiation of cell-mediated immune responses against recombinant HN protein of Newcastle disease virus by recombinant chicken IL-18. (21507491)
2011
31
Immunoadjuvant activities of a recombinant chicken IL-12 in chickens vaccinated with Newcastle disease virus recombinant HN protein. (21420255)
2011
32
Generation and evaluation of a recombinant Newcastle disease virus expressing the glycoprotein (G) of avian metapneumovirus subgroup C as a bivalent vaccine in turkeys. (21925228)
2011
33
Comparative effect of Lactobacillus casei and a commercial mangosteen dietary supplement on body weight gain and antibody response to Newcastle disease virus vaccine in fighting roosters. (21548799)
2011
34
Neurological lesions in chickens experimentally infected with virulent Newcastle disease virus isolates. (21500034)
2011
35
Immuno-PCR for one step detection of H5N1 avian influenza virus and Newcastle disease virus using magnetic gold particles as carriers. (21511345)
2011
36
Triggering of the newcastle disease virus fusion protein by a chimeric attachment protein that binds to Nipah virus receptors. (21460213)
2011
37
The influence of the inactivating agent on the antigen content of inactivated Newcastle disease vaccines assessed by the in vitro potency test. (19716316)
2010
38
Sequence and phylogenetic analysis of Newcastle disease virus genotypes isolated in Malaysia between 2004 and 2005. (19898736)
2010
39
Molecular characterization of partial fusion gene and C-terminus extension length of haemagglutinin-neuraminidase gene of recently isolated Newcastle disease virus isolates in Malaysia. (20691110)
2010
40
Platycodin d improves the immunogenicity of newcastle disease virus-based recombinant avian influenza vaccine in mice. (20232336)
2010
41
Intramuscular inoculation of calves with an experimental Newcastle disease virus-based vector vaccine elicits neutralizing antibodies against Rift Valley fever virus. (20079874)
2010
42
Screening and identification of differentially expressed genes from chickens infected with Newcastle disease virus by suppression subtractive hybridization. (20544419)
2010
43
Protection and differentiation of infected from vaccinated animals by an inactivated recombinant Newcastle disease virus/avian influenza H5 vaccine. (20521639)
2010
44
The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease. (19570697)
2010
45
Evaluation of encapsulated Newcastle disease virus liposomes using various phospholipids administered to improve chicken humoral immunity. (19582853)
2009
46
Cloning of a gene fragment encoding chicken complement component C3d with expression and immunogenicity of Newcastle disease virus F gene-C3d fusion protein. (18798021)
2008
47
p53-independent endoplasmic reticulum stress-mediated cytotoxicity of a Newcastle disease virus strain in tumor cell lines. (17215292)
2007
48
Selective gene transfer in vitro to tumor cells via recombinant Newcastle disease virus. (15605075)
2005
49
Newcastle disease virus neuraminidase primes neutrophils for stimulation by galectin-3 and formyl-Met-Leu-Phe. (15242763)
2004
50
Serum protease inhibitor abrogation of Newcastle disease virus enhancement of cytolysis by recombinant tumor necrosis factors alpha and beta. (2296051)
1990

Genetic Variations for Newcastle Disease

About this section

Expression for genes affiliated with Newcastle Disease

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Newcastle Disease

Search GEO for disease gene expression data for Newcastle Disease.

Pathways for genes affiliated with Newcastle Disease

About this section
Sources:
37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 29KEGG, 12EMD Millipore
See all sources

Pathways related to Newcastle Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IFNB1, IRF1, CXCL10
210.2DDX58, IRF1, IRF3
3
Hide members
10.2BIRC7, IRF1, IRF3
4
Hide members
10.1IRF3, IFNB1, IFNA1
5
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
10.1IFNA1, IFNB1, IRF3
6
Hide members
10.0DDX58, IRF3, IFNB1, IFNA1
7
Immune response IFN alpha/beta signaling pathway
Hide members
10.0MX1, IRF1, IRF3, IFNB1, IFNA1
810.0IFNA1, IFNB1, IRF3, IRF1, DDX58
9
Hide members
10.0IFNA1, IFNB1, IRF3, DDX58, CXCL10
10
Hide members
10.0IFNA1, IFNB1, IRF3, DDX58, CXCL10
11
Hide members
9.9IFNA1, IFNB1, IRF3, IRF1, DDX58, MX1
12
Hide members
9.8IFNA1, IFNB1, IRF3, DDX58, IVNS1ABP, CXCL10
13
Hide members
9.6IFNA1, IFNB1, IRF3, IRF1, DDX58, DDX58

Compounds for genes affiliated with Newcastle Disease

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Newcastle Disease according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1ribavirin44 49 1112.7MX1, NEU1, LBR
2swainsonine44 1111.6NEU1, LGALS1
3gal(beta1-3)galnac4410.6NEU1, LGALS1
4rebif4410.6MX1, IFNB1, IFNA1
5avonex4410.6IFNA1, IFNB1, MX1
6acyclovir44 1111.6IFNA1, IFNB1, NEU1
7betaseron4410.6MX1, IFNB1, IFNA1
8con a4410.6LBR, NEU1, LGALS1
9indoleamine4410.6IRF1, IFNB1, IFNA1
10phytate4410.5GRK1, IFNB1
11imiquimod44 28 59 1113.5IFNA1, IFNB1, MX1
12n-acetyllactosamine44 2411.5LGALS7, LGALS1, NEU1
13ccl344 2811.5CXCL10, IFNB1, IFNA1
14mezerein4410.5IFNB1, IFNA1
15zidovudine44 1111.5NEU1, LBR, IFNB1, IFNA1
16kynurenine4410.5IFNB1, IFNA1
17inosine monophosphate4410.5IFNA1, IFNB1, IRF3, IRF1
18chloroquine44 2 49 28 1114.5CXCL10, IFNB1, IFNA1
19polyacrylamide4410.4LGALS1, GRK1, NEU1, CTRL
20amantadine44 1111.4IFNA1, NEU1
21cycloheximide4410.4IFNA1, IFNB1, IRF1, CXCL10, MX1
222,5-oligoadenylate4410.4IFNA1, IFNB1, IRF1, CXCL10, MX1
23rantes4410.4IFNA1, IFNB1, IRF3, IRF1, LBR
24neopterin4410.4IFNA1, IFNB1, LBR, CXCL10, MX1
25chloramphenicol44 2 1112.4IFNB1, IRF3, IRF1, LBR, MX1
26polylactosamine4410.4NEU1, LGALS1
27galactose4410.4NEU1, LGALS1, LGALS7
28purine44 2411.4IFNB1, LBR, GRK1
29tamoxifen44 49 28 1113.4IFNA1, IFNB1, IRF1, CTRL
30retinoid4410.4IFNA1, IFNB1, IRF1, LGALS1
31thymidine44 2411.3IFNA1, IFNB1, IRF1, LBR, CXCL10
32serine4410.3IRF1, CTRL, NEU1, GRK1, BIRC7, MX1
33etoposide44 49 59 1113.3IFNA1, IFNB1, IRF1, BIRC7, LGALS1
34polyinosinic-polycytidylic acid4410.3IFNA1, IFNB1, IRF3, IRF1, DDX58, CXCL10
35ifn-alpha4410.3IFNA1, IFNB1, IRF3, IRF1, CXCL10, MX1
36heparin44 28 11 2413.3IFNB1, CTRL, LBR, NEU1, LGALS1
37histamine44 28 2412.3CXCL10, NEU1, LBR, CTRL
38zinc44 2411.3IFNB1, IRF3, IRF1, CTRL, LBR, GRK1
39glatiramer acetate44 1111.3IFNB1, IFNA1
40nucleoside4410.2IFNA1, IFNB1, GRK1
41poly(i-c)4410.2MX1, IFNA1, IFNB1, IRF3, IRF1, DDX58
42monosaccharide4410.2NEU1, LGALS1
43lipid4410.2IFNB1, IRF3, IRF1, LBR, CXCL10, MX1
44dexamethasone44 49 28 1113.1LGALS1, LBR, IFNB1, IFNA1
45tyrosine4410.0IFNA1, IFNB1, IRF3, IRF1, CTRL, LBR
46didanosine44 1111.0IFNA1, LBR
47retinoic acid44 2410.9IFNA1, IFNB1, IRF3, IRF1, CTRL, LBR

GO Terms for genes affiliated with Newcastle Disease

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Newcastle Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to exogenous dsRNAGO:04333010.3DDX58, IRF3
2positive regulation of interferon-beta productionGO:03272810.3IRF3, IRF1, DDX58
3type I interferon-mediated signaling pathwayGO:06033710.2MX1, IRF1, IRF3, IFNB1
4positive regulation of interferon-alpha productionGO:03272710.2DDX58, IRF3
5defense response to virusGO:05160710.1IFNB1, IRF3, IRF1, CXCL10, MX1
6response to virusGO:00961510.1MX1, IVNS1ABP, DDX58, IFNB1, CCDC130
7cytokine-mediated signaling pathwayGO:01922110.1MX1, IRF1, IRF3, IFNB1
8apoptotic processGO:0069159.7IRF3, IRF1, GRK1, MX1, LGALS1

Products for genes affiliated with Newcastle Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Newcastle Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet