MCID: NWC001
MIFTS: 54

Newcastle Disease malady

Summaries for Newcastle Disease

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection in birds and humans, has material basis in newcastle disease virus, which is transmitted by contact with feces and urine of an infected bird, or transmitted by fomites. the infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.

MalaCards: Newcastle Disease, also known as newcastle's disease, is related to influenza and encephalitis, and has symptoms including reduced egg production in birds, conjunctivitis and lacrimation in humans. An important gene associated with Newcastle Disease is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Type II interferon signaling (IFNG) and NF-kappaB Signaling. The compounds ribavirin and swainsonine have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and testes, and related mouse phenotype cellular.

Wikipedia:63 Newcastle disease is a contagious bird disease affecting many domestic and wild avian species; it is... more...

Aliases & Classifications for Newcastle Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

newcastle disease 8 10 44 60
newcastle's disease 8
pseudo-fowlpest 8


External Ids:

Disease Ontology8 DOID:2929
MeSH34 D009521
NCIt39 C34849

Related Diseases for Newcastle Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Newcastle Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1influenza31.2MX1, CXCL10, IFNA1, IFNB1, IRF3, IRF1
2encephalitis30.3CXCL10, IFNA1, MX1
3prostate cancer30.2MX1, LGALS1, CXCL10, CTRL
4lung cancer30.2LGALS1, LBR, IRF1, IRF3, IFNB1, BIRC7
5adenocarcinoma30.2LGALS1, IFNB1, CXCL10, IRF1
6melanoma30.1IFNA1, MX1, LGALS1, BIRC7, LBR, IRF1
7mumps29.9NEU1, IRF1
8rabies29.9MX1
9astrocytoma29.9CXCL10, IRF1, IFNB1
10measles29.9MX1, IFNB1, LBR, IRF1
11arthritis29.9MX1, CXCL10, IRF1, IVNS1ABP
12hepatitis29.9IFNB1, IFNA1, CXCL10
13hepatocellular carcinoma29.9IFNB1, LGALS1, IRF1, NEU1, IFNA1
14leukemia29.9IRF1, IFNA1, CTRL, LGALS1, LBR, IFNB1
15avian influenza10.8
16bronchitis10.4
17laryngotracheitis10.4
18pancreatitis10.3
19coats disease10.2
20stomatitis10.2
21brain disease10.1
22peritonitis10.1
23prostate disease10.1
24prostatitis10.1
25dengue hemorrhagic fever10.0IVNS1ABP
26cervical cancer10.0IRF1
27sarcoma10.0LGALS1
28cryoglobulinemic vasculitis10.0IFNA1
29lupus erythematosus10.0MX1
30severe acute respiratory syndrome10.0CXCL10, CTRL
31myelodysplastic syndromes10.0IRF1
32cryoglobulinemia10.0IFNA1
33biliary atresia10.0CXCL10, MX1
34malaria10.0NEU1
35dermatomyositis10.0MX1
36lichen planus10.0MX1
37multiple myeloma10.0CTRL
38hemophagocytic lymphohistiocytosis10.0IFNB1, MX1
39thrombocytopenia10.0IFNA1
40dengue disease10.0IFNB1, IVNS1ABP, NEU1
41acute leukemia10.0IRF1
42thymoma10.0STK16, LBR
43subacute sclerosing panencephalitis10.0IRF1, IFNA1, MX1
44stomach cancer10.0IRF1, CTRL, IFNB1
45relapsing-remitting multiple sclerosis10.0MX1, IFNB1, IFNA1
46kaposi's sarcoma10.0IFNB1, IFNA1, CXCL10, LBR
47psoriasis10.0CXCL10, IRF1, MX1
48dermatitis10.0CXCL10
49hepatitis b10.0IFNA1, MX1, CXCL10
50encephalomyelitis10.0CXCL10, IFNB1

Graphical network of the top 20 diseases related to Newcastle Disease:



Diseases related to newcastle disease

Clinical Features for Newcastle Disease

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8Disease Ontology
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Symptoms:

8 (show all 10)
  • reduced egg production in birds
  • conjunctivitis
  • lacrimation in humans
  • gasping
  • coughing
  • twisting of head
  • circling
  • complete paralysis
  • watery diarrhea
  • headache

Drugs & Therapeutics for Newcastle Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Newcastle Disease

Drug clinical trials:

Search ClinicalTrials for Newcastle Disease

Search NIH Clinical Center for Newcastle Disease

Search CenterWatch for Newcastle Disease

Genetic Tests for Newcastle Disease

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Anatomical Context for Newcastle Disease

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32MalaCards
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MalaCards organs/tissues related to Newcastle Disease:

32
T cells, Lung, Testes, Prostate, Brain, Tongue, Kidney, Breast, Monocytes, Tonsil, Trachea, Bone

Animal Models for Newcastle Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Newcastle Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053849.6CXCL10, GRK1, IVNS1ABP, NEU1, DDX58, LBR

Publications for Newcastle Disease

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Sources:
50PubMed
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Articles related to Newcastle Disease:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Analysis of synonymous codon usage in Newcastle disease virus hemagglutinin-neuraminidase (HN) gene and fusion protein (F) gene. (24426322)
2014
2
Molecular epidemiological investigation of velogenic Newcastle disease viruses from village chickens in Cambodia. (23764918)
2013
3
Characterization of newcastle disease viruses in wild and domestic birds in Luxembourg from 2006 to 2008. (23160119)
2013
4
Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range. (23426356)
2013
5
The oncolytic activity of Newcastle disease virus in clear cell renal carcinoma cells in normoxic and hypoxic conditions: the interplay between von Hippel-Lindau and interferon-I^ signaling. (23506478)
2013
6
Genetic diversity of Newcastle disease virus in Pakistan: a countrywide perspective. (23721461)
2013
7
Modulation of Humoral and Cell-Mediated Immunity Against Avian Influenza and Newcastle Disease Vaccines by Oral Administration of Salmonella enterica Serovar Typhimurium Expressing Chicken Interleukin-18. (23559899)
2013
8
Complete genome sequencing and analysis of an anti-tumor Newcastle disease virus strain. (23664979)
2013
9
Newcastle disease virus Malaysian strain AF2240 induces apoptosis in MCF-7 human breast carcinoma cells at an early stage of the virus life cycle. (23337979)
2013
10
Rescue of recombinant Newcastle disease virus from cDNA. (24145366)
2013
11
Antiviral activity of sulfated Chuanmingshen violaceum polysaccharide against Newcastle disease virus. (23884364)
2013
12
Application of the ligation-independent cloning (LIC) method for rapid construction of a minigenome rescue system for Newcastle disease virus VG/GA strain. (23928042)
2013
13
Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin. (23698299)
2013
14
Suitability of differently formulated dry powder Newcastle disease vaccines for mass vaccination of poultry. (22155763)
2012
15
Complete genome sequence of a Newcastle disease virus strain isolated from broiler breeder flocks in China. (23087120)
2012
16
Long-term and memory immune responses in mice against Newcastle disease virus-like particles containing respiratory syncytial virus glycoprotein ectodomains. (22896618)
2012
17
Newcastle disease. Editorial. (22834544)
2012
18
Molecular epidemiology of outbreak-associated and wild-waterfowl-derived newcastle disease virus strains in Finland, including a novel class I genotype. (22972821)
2012
19
Effect of short-term water restriction in hot season on some blood parameters and immune response to Newcastle disease vaccine of local and commercial layers in the late phase of production. (21777294)
2012
20
I+2-3- and I+2-6- N-linked sialic acids allow efficient interaction of Newcastle Disease Virus with target cells. (22869099)
2012
21
Phylogeny and evolution of Newcastle disease virus genotypes isolated in Asia during 2008-2011. (22453861)
2012
22
Adjuvant effects of Sijunzi decoction in chickens orally vaccinated with attenuated Newcastle-disease vaccine. (23983329)
2012
23
Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity. (22102168)
2012
24
Detection and differentiation of virulent and avirulent strains of Newcastle disease virus by real-time PCR. (21192979)
2011
25
A single amino acid change, Q114R, in the cleavage-site sequence of Newcastle disease virus fusion protein attenuates viral replication and pathogenicity. (21677091)
2011
26
Development and in vitro characterization of a bivalent DNA containing HN and F genes of velogenic Newcastle disease virus. (21428216)
2011
27
Analysis of the fusion protein gene of Newcastle disease viruses isolated in Japan. (20736513)
2011
28
Efficacy of Newcastle disease virus recombinant expressing avian influenza virus H6 hemagglutinin against Newcastle disease and low pathogenic avian influenza in chickens and turkeys. (21793434)
2011
29
Early occurrence of apoptosis in lymphoid tissues from chickens infected with strains of Newcastle disease virus of varying virulence. (21511269)
2011
30
Whole genome sequencing and characterization of a virulent Newcastle disease virus isolated from an outbreak in Sweden. (21667282)
2011
31
Detecting Newcastle disease virus in combination of RT-PCR with red blood cell absorption. (21535888)
2011
32
Putative protective antibody response following oral vaccination of multi-age free ranging helmeted guinea fowls (Numida meleagris) with Newcastle disease virus strain I-2 coated on oiled rice. (20878470)
2011
33
A survey for maintenance of virulent newcastle disease virus-free area in poultry production in Brazil. (24031506)
2010
34
Analysis of Newcastle disease virus quasispecies and factors affecting the emergence of virulent virus. (20602243)
2010
35
DNA-chitosan nanoparticles improve DNA vaccine-elicited immunity against Newcastle disease virus through shuttling chicken interleukin-2 gene. (21034363)
2010
36
Detection of free peritoneal cancer cells in gastric cancer using cancer-specific Newcastle disease virus. (19902312)
2010
37
Antitumor efficacy of viral therapy using genetically engineered Newcastle disease virus [NDV(F3aa)-GFP] for peritoneally disseminated gastric cancer. (20393691)
2010
38
Generation and evaluation of a Newcastle disease virus-based H9 avian influenza live vaccine. (20521648)
2010
39
Characterization of newly emerging Newcastle disease viruses isolated during 2002-2008 in Taiwan. (19941916)
2010
40
Emergence of a new genetic lineage of Newcastle disease virus in West and Central Africa--implications for diagnosis and control. (19939590)
2010
41
Occurrence and transmission of Newcastle disease virus aerosol originating from infected chickens under experimental conditions. (19091492)
2009
42
Comparison of viral shedding following vaccination with inactivated and live Newcastle disease vaccines formulated with wild-type and recombinant viruses. (19432002)
2009
43
Immunization of chickens with Newcastle disease virus expressing H5 hemagglutinin protects against highly pathogenic H5N1 avian influenza viruses. (19654873)
2009
44
Outbreak of Newcastle disease due to pigeon paramyxovirus type 1 in grey partridges (Perdix perdix) in Scotland in October 2006. (19880861)
2009
45
Characterization of Newcastle disease viruses isolated from chicken, gamefowl, pigeon and quail in Mexico. (19784791)
2009
46
Potential use of the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus expressed in Rachiplusia nu larvae as an immunogen for chickens. (19297615)
2009
47
Effect of lipopolysaccharide on intranasal administration of liposomal Newcastle disease virus vaccine to SPF chickens. (19439366)
2009
48
Protection of chickens from Newcastle disease with a recombinant baculovirus subunit vaccine expressing the fusion and hemagglutininneuraminidase proteins. (18716451)
2008
49
Retinoic acid enhances killing of neuroblastoma cells by Newcastle disease virus. (8263678)
1993
50
Demonstration of low-pathogenicity laryngotracheitis virus in a chicken flock affected by Newcastle disease. (200130)
1976

Genetic Variations for Newcastle Disease

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Expression for genes affiliated with Newcastle Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Newcastle Disease

Search GEO for disease gene expression data for Newcastle Disease.

Pathways for genes affiliated with Newcastle Disease

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Sources:
37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 29KEGG, 12EMD Millipore
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Pathways related to Newcastle Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CXCL10, IRF1, IFNB1
210.2IRF3, DDX58, IRF1
3
Hide members
10.2IRF1, IRF3, BIRC7
4
Hide members
10.1IFNB1, IRF3, IFNA1
5
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
10.1IFNB1, IRF3, IFNA1
6
Hide members
10.0DDX58, IRF3, IFNA1, IFNB1
7
Immune response IFN alpha/beta signaling pathway
Hide members
10.0IRF1, MX1, IFNA1, IRF3, IFNB1
810.0DDX58, IRF3, IFNA1, IRF1, IFNB1
9
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10.0IFNB1, IRF3, CXCL10, DDX58, IFNA1
10
Hide members
10.0CXCL10, DDX58, IRF3, IFNB1, IFNA1
11
Hide members
9.9IRF3, IFNA1, IFNB1, IRF1, DDX58, MX1
12
Hide members
9.8MX1, IFNA1, CXCL10, IVNS1ABP, DDX58, IRF3
13
Hide members
9.6DCTN6, MX1, DDX58, IRF3, IFNB1, IFNA1

Compounds for genes affiliated with Newcastle Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Newcastle Disease according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1ribavirin44 49 1112.7MX1, NEU1, LBR
2swainsonine44 1111.6NEU1, LGALS1
3gal(beta1-3)galnac4410.6NEU1, LGALS1
4rebif4410.6MX1, IFNB1, IFNA1
5avonex4410.6IFNA1, IFNB1, MX1
6acyclovir44 1111.6IFNA1, IFNB1, NEU1
7betaseron4410.6MX1, IFNB1, IFNA1
8con a4410.6LBR, NEU1, LGALS1
9indoleamine4410.6IRF1, IFNB1, IFNA1
10phytate4410.5GRK1, IFNB1
11imiquimod44 28 59 1113.5IFNA1, IFNB1, MX1
12n-acetyllactosamine44 2411.5LGALS7, LGALS1, NEU1
13ccl344 2811.5CXCL10, IFNB1, IFNA1
14mezerein4410.5IFNB1, IFNA1
15zidovudine44 1111.5NEU1, LBR, IFNB1, IFNA1
16kynurenine4410.5IFNB1, IFNA1
17inosine monophosphate4410.5IFNA1, IFNB1, IRF3, IRF1
18chloroquine44 2 49 28 1114.5CXCL10, IFNB1, IFNA1
19polyacrylamide4410.4LGALS1, GRK1, NEU1, CTRL
20amantadine44 1111.4IFNA1, NEU1
21cycloheximide4410.4IFNA1, IFNB1, IRF1, CXCL10, MX1
222,5-oligoadenylate4410.4IFNA1, IFNB1, IRF1, CXCL10, MX1
23rantes4410.4IFNA1, IFNB1, IRF3, IRF1, LBR
24neopterin4410.4IFNA1, IFNB1, LBR, CXCL10, MX1
25chloramphenicol44 2 1112.4IFNB1, IRF3, IRF1, LBR, MX1
26polylactosamine4410.4NEU1, LGALS1
27galactose4410.4NEU1, LGALS1, LGALS7
28purine44 2411.4IFNB1, LBR, GRK1
29tamoxifen44 49 28 1113.4IFNA1, IFNB1, IRF1, CTRL
30retinoid4410.4IFNA1, IFNB1, IRF1, LGALS1
31thymidine44 2411.3IFNA1, IFNB1, IRF1, LBR, CXCL10
32serine4410.3IRF1, CTRL, NEU1, GRK1, BIRC7, MX1
33etoposide44 49 59 1113.3IFNA1, IFNB1, IRF1, BIRC7, LGALS1
34polyinosinic-polycytidylic acid4410.3IFNA1, IFNB1, IRF3, IRF1, DDX58, CXCL10
35ifn-alpha4410.3IFNA1, IFNB1, IRF3, IRF1, CXCL10, MX1
36heparin44 28 11 2413.3IFNB1, CTRL, LBR, NEU1, LGALS1
37histamine44 28 2412.3CXCL10, NEU1, LBR, CTRL
38zinc44 2411.3IFNB1, IRF3, IRF1, CTRL, LBR, GRK1
39glatiramer acetate44 1111.3IFNB1, IFNA1
40nucleoside4410.2IFNA1, IFNB1, GRK1
41poly(i-c)4410.2MX1, IFNA1, IFNB1, IRF3, IRF1, DDX58
42monosaccharide4410.2NEU1, LGALS1
43lipid4410.2IFNB1, IRF3, IRF1, LBR, CXCL10, MX1
44dexamethasone44 49 28 1113.1LGALS1, LBR, IFNB1, IFNA1
45tyrosine4410.0IFNA1, IFNB1, IRF3, IRF1, CTRL, LBR
46didanosine44 1111.0IFNA1, LBR
47retinoic acid44 2410.9IFNA1, IFNB1, IRF3, IRF1, CTRL, LBR

GO Terms for genes affiliated with Newcastle Disease

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16Gene Ontology
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Biological processes related to Newcastle Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to exogenous dsRNAGO:04333010.3DDX58, IRF3
2positive regulation of interferon-beta productionGO:03272810.3IRF3, IRF1, DDX58
3type I interferon-mediated signaling pathwayGO:06033710.2MX1, IRF1, IRF3, IFNB1
4positive regulation of interferon-alpha productionGO:03272710.2DDX58, IRF3
5defense response to virusGO:05160710.1IFNB1, IRF3, IRF1, CXCL10, MX1
6response to virusGO:00961510.1MX1, IVNS1ABP, DDX58, IFNB1, CCDC130
7cytokine-mediated signaling pathwayGO:01922110.1MX1, IRF1, IRF3, IFNB1
8apoptotic processGO:0069159.7IRF3, IRF1, GRK1, MX1, LGALS1

Products for genes affiliated with Newcastle Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Newcastle Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet