MCID: NWC001
MIFTS: 54

Newcastle Disease malady

Infectious diseases category
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Summaries for Newcastle Disease

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection in birds and humans, has material basis in newcastle disease virus, which is transmitted by contact with feces and urine of an infected bird, or transmitted by fomites. the infection has symptom conjunctivitis, has symptom headache, and has symptom lacrimation in humans, and has symptom gasping, has symptom coughing, has symptom twisting of head and neck, has symptom circling, has symptom complete paralysis, has symptom watery diarrhea, and has symptom reduced egg production in birds.

MalaCards: Newcastle Disease, also known as newcastle's disease, is related to influenza and adenocarcinoma, and has symptoms including reduced egg production in birds, conjunctivitis and lacrimation in humans. An important gene associated with Newcastle Disease is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Cytosolic sensors of pathogen-associated DNA and Hepatitis C. The compounds acyclovir and fluticasone propionate have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and prostate, and related mouse phenotypes are skeleton and hematopoietic system.

Wikipedia:65 Newcastle disease is a contagious bird disease affecting many domestic and wild avian species; it is... more...

Aliases & Classifications for Newcastle Disease

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

newcastle disease 8 10 45 62
newcastle's disease 8
pseudo-fowlpest 8


External Ids:

Disease Ontology8 DOID:2929
NCIt40 C34849
MeSH35 D009521

Related Diseases for Newcastle Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Newcastle Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1influenza31.0IFNB1, CXCL10, NEU1, LBR, IRF1
2adenocarcinoma30.1IFNB1, IRF1, CXCL10
3lung cancer30.1LBR, IRF1, IFNB1
4mumps30.0NEU1, IRF1
5hepatitis30.0IFNB1, CXCL10
6astrocytoma29.9CXCL10, IFNB1, IRF1
7hepatocellular carcinoma29.9IFNB1, NEU1, IRF1
8melanoma29.9NEU1, IRF1, CXCL10, CTRL, IFNB1, LBR
9measles29.9LBR, IFNB1, IRF1
10leukemia29.8CTRL, IFNB1, LBR, IRF1
11avian influenza10.8
12bronchitis10.4
13laryngotracheitis10.4
14pancreatitis10.3
15encephalitis10.2
16stomatitis10.2
17peritonitis10.1
18prostate cancer10.1
19prostatitis10.1
20malaria10.1NEU1
21progressive multifocal leukoencephalopathy10.1IFNB1
22dengue disease10.1NEU1, IFNB1
23respiratory failure10.0CXCL10, NEU1
24severe acute respiratory syndrome10.0CTRL, CXCL10
25neutropenia10.0IFNB1, CXCL10
26myocarditis10.0IRF1, IFNB1
27encephalomyelitis10.0IFNB1, CXCL10
28cholera10.0NEU1, IFNB1
29iga glomerulonephritis10.0NEU1, LBR
30tetanus10.0LBR, NEU1
31idiopathic pulmonary fibrosis10.0LBR, CXCL10
32graves' disease10.0CXCL10, IRF1
33pneumonia10.0IRF1, NEU1, CXCL10
34hepatitis c10.0IFNB1, CXCL10, IRF1
35rift valley fever10.0
36eastern equine encephalitis10.0
37tracheitis10.0
38tonsillitis10.0
39rabies10.0
40phaeochromocytoma10.0
41arthritis10.0
42lung adenocarcinoma10.0
43malignant glioma10.0
44malignant pleural mesothelioma10.0
45neuroblastoma10.0
46pancreatic cancer10.0
47anaplastic astrocytoma10.0
48parainfluenza virus type 310.0
49hiv-110.0
50ulcerative colitis10.0IRF1, CXCL10, IFNB1

Graphical network of the top 20 diseases related to Newcastle Disease:



Diseases related to newcastle disease

Symptoms for Newcastle Disease

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8Disease Ontology
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Symptoms:

8 (show all 10)
  • reduced egg production in birds
  • conjunctivitis
  • lacrimation in humans
  • gasping
  • coughing
  • twisting of head
  • circling
  • complete paralysis
  • watery diarrhea
  • headache

Drugs & Therapeutics for Newcastle Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Newcastle Disease

Search NIH Clinical Center for Newcastle Disease

Genetic Tests for Newcastle Disease

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Anatomical Context for Newcastle Disease

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Sources:
33MalaCards
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MalaCards organs/tissues related to Newcastle Disease:

33
T cells, Lung, Prostate, Testes, Brain, Bone, Kidney, Breast, Monocytes, Trachea, Tonsil, Tongue

Animal Models for Newcastle Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Newcastle Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.2IFNB1, IRF1, NEU1, LBR
2MP:00053977.6IFNB1, CXCL10, IRF1, NEU1, LBR
3MP:00053877.5LBR, NEU1, IRF1, CXCL10, IFNB1
4MP:00053767.3LBR, NEU1, IRF1, CXCL10, IFNB1

Publications for Newcastle Disease

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52PubMed
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Articles related to Newcastle Disease:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Analysis of synonymous codon usage in Newcastle disease virus hemagglutinin-neuraminidase (HN) gene and fusion protein (F) gene. (24426322)
2014
2
In vitro and in vivo broad antiviral activity of peptides homologous to fusion glycoproteins of Newcastle disease virus and Marek's disease virus. (24412629)
2014
3
Induction of apoptosis in MCF-7 cells by the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus Malaysian strain AF2240. (23807159)
2013
4
Recovery of avirulent, thermostable Newcastle disease virus strain NDV4-C from cloned cDNA and stable expression of an inserted foreign gene. (23657741)
2013
5
Molecular epidemiological investigation of velogenic Newcastle disease viruses from village chickens in Cambodia. (23764918)
2013
6
Preparation and Efficacy of Newcastle Disease Virus DNA Vaccine Encapsulated in PLGA Nanoparticles. (24386106)
2013
7
Complete genome sequence of a newcastle disease virus strain belonging to a recently identified genotype. (23405340)
2013
8
Characterization of newcastle disease viruses in wild and domestic birds in Luxembourg from 2006 to 2008. (23160119)
2013
9
Heterologous expression, characterization and evaluation of the matrix protein from Newcastle disease virus as a target for antiviral therapies. (23797330)
2013
10
Effects of the HN gene C-terminal extensions on the Newcastle disease virus virulence. (24037042)
2013
11
Preparation and diagnostic utility of a hemagglutination inhibition test antigen derived from the baculovirus-expressed hemagglutinin-neuraminidase protein gene of Newcastle disease virus. (23820164)
2013
12
Characterization of Newcastle disease viruses isolated from cormorant and gull species in the United States in 2010. (22545538)
2012
13
Risk factors for avian influenza and Newcastle disease in smallholder farming systems, Madagascar highlands. (22130311)
2012
14
Biological characterization and phylogenetic analysis of a novel genetic group of Newcastle disease virus isolated from outbreaks in commercial poultry and from backyard poultry flocks in Pakistan. (22418457)
2012
15
Complete genome sequencing of a novel newcastle disease virus isolate circulating in layer chickens in the Dominican Republic. (22879619)
2012
16
Biological and phylogenetic characterization of a genotype VII Newcastle disease virus from Venezuela: efficacy of field vaccination. (22238433)
2012
17
Effect of immunosuppression on newcastle disease virus persistence in ducks with different immune status. (23738119)
2012
18
Surveillance for avian influenza and Newcastle disease in backyard poultry flocks in CA'te d'Ivoire, 2007-2009. (23520736)
2012
19
Molecular characterization of a recent Newcastle disease virus outbreak in Jordan. (22480768)
2012
20
Lack of detection of host associated differences in Newcastle disease viruses of genotype VIId isolated from chickens and geese. (22971647)
2012
21
Virulent Newcastle disease virus in Nigeria: identification of a new clade of sub-lineage 5f from livebird markets. (21960434)
2012
22
A simple fluorescent labeling technique to study virus adsorption in Newcastle disease virus infected cells. (22112508)
2011
23
The matrix (M) protein of Newcastle disease virus binds to human bax through its BH3 domain. (21810274)
2011
24
Rescue of Newcastle disease virus from cloned cDNA using an RNA polymerase II promoter. (21327786)
2011
25
Virulent Newcastle disease virus elicits a strong innate immune response in chickens. (21177922)
2011
26
Detection and differentiation of virulent and avirulent strains of Newcastle disease virus by real-time PCR. (21192979)
2011
27
A single amino acid change, Q114R, in the cleavage-site sequence of Newcastle disease virus fusion protein attenuates viral replication and pathogenicity. (21677091)
2011
28
Immunogenicity of a truncated enterovirus 71 VP1 protein fused to a Newcastle disease virus nucleocapsid protein fragment in mice. (21978156)
2011
29
Newcastle disease virus-vectored rabies vaccine is safe, highly immunogenic, and provides long-lasting protection in dogs and cats. (21632762)
2011
30
Construction of a minigenome rescue system for Newcastle disease virus strain Italien. (21207083)
2011
31
Newcastle disease virus in Madagascar: identification of an original genotype possibly deriving from a died out ancestor of genotype IV. (21085573)
2010
32
The influence of the inactivating agent on the antigen content of inactivated Newcastle disease vaccines assessed by the in vitro potency test. (19716316)
2010
33
Avian influenza virus and Newcastle disease virus (NDV) surveillance in commercial breeding farm in China and the characterization of Class I NDV isolates. (20133090)
2010
34
Type I interferon-sensitive recombinant newcastle disease virus for oncolytic virotherapy. (20147405)
2010
35
Overexpression of Newcastle disease virus (NDV) V protein enhances NDV production kinetics in chicken embryo fibroblasts. (19730851)
2010
36
Respiratory tract immunization of non-human primates with a Newcastle disease virus-vectored vaccine candidate against Ebola virus elicits a neutralizing antibody response. (21034822)
2010
37
Sequence and phylogenetic analysis of Newcastle disease virus genotypes isolated in Malaysia between 2004 and 2005. (19898736)
2010
38
Inhibition of host innate immune responses and pathogenicity of recombinant Newcastle disease viruses expressing NS1 genes of influenza A viruses. (20410312)
2010
39
Newcastle disease virus infection promotes Bax redistribution to mitochondria and cell death in HeLa cells. (19955813)
2010
40
Lycium barbarum polysaccharide inhibits the infectivity of Newcastle disease virus to chicken embryo fibroblast. (19962398)
2010
41
Molecular characterization of partial fusion gene and C-terminus extension length of haemagglutinin-neuraminidase gene of recently isolated Newcastle disease virus isolates in Malaysia. (20691110)
2010
42
The hemagglutinin-neuraminidase gene of Newcastle Disease Virus: a powerful molecular adjuvant for DNA anti-tumor vaccination. (20709006)
2010
43
Genetically engineered Newcastle disease virus for malignant melanoma therapy. (19242529)
2009
44
Optimization of human immunodeficiency virus gag expression by newcastle disease virus vectors for the induction of potent immune responses. (19004953)
2009
45
Newcastle disease outbreaks in Kazakhstan and Kyrgyzstan during 1998, 2000, 2001, 2003, 2004, and 2005 were caused by viruses of the genotypes VIIb and VIId. (19466536)
2009
46
Evidence for a role of mast cells in the mucosal injury induced by Newcastle disease virus. (19211524)
2009
47
Occurrence and transmission of Newcastle disease virus aerosol originating from infected chickens under experimental conditions. (19091492)
2009
48
Overexpression of thiol/disulfide isomerases enhances membrane fusion directed by the Newcastle disease virus fusion protein. (18829746)
2008
49
Characterization of a recombinant Newcastle disease virus vaccine strain. (18768673)
2008
50
Experimental infections of wild birds with the viruses of eastern equine encephalitis, Newcastle disease and vesicular stomatitis. (14404590)
1959

Variations for Newcastle Disease

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Expression for genes affiliated with Newcastle Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Newcastle Disease

Search GEO for disease gene expression data for Newcastle Disease.

Pathways for genes affiliated with Newcastle Disease

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Sources:
50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters
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Pathways related to Newcastle Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5IFNB1, CXCL10
29.4IFNB1, IRF1
39.4IFNB1, IRF1
49.4IFNB1, IRF1
5
Show member pathways
9.4IRF1, IFNB1
68.9IFNB1, CXCL10, IRF1
7
Show member pathways
8.9IFNB1, CXCL10, IRF1
8
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.9IRF1, CXCL10, IFNB1

Compounds for genes affiliated with Newcastle Disease

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Newcastle Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1acyclovir45 1111.0IFNB1, NEU1
2fluticasone propionate45 51 61 1112.8CXCL10, IFNB1
3il 10459.8CXCL10, IFNB1
4tarc459.8IFNB1, CXCL10
5ccl345 2910.8CXCL10, IFNB1
6indoleamine459.8IFNB1, IRF1
7ccl445 2910.8IFNB1, CXCL10
8inosine monophosphate459.7IFNB1, IRF1
9con a459.6NEU1, LBR
10chloroquine45 3 51 29 1113.6IFNB1, CXCL10
11tetracycline45 1110.5IFNB1, IRF1
12n-ethylmaleimide45 1110.5NEU1, CTRL
13pdtc459.5CTRL, IRF1
14guanosine 5-o-(3-thiotriphosphate)459.5CTRL, LBR
15infliximab45 51 1111.4CXCL10, LBR
16dbc-amp459.4LBR, IFNB1
17deferoxamine45 1110.4IRF1, LBR
182,5-oligoadenylate459.3IRF1, CXCL10, IFNB1
19polyinosinic-polycytidylic acid459.3IRF1, CXCL10, IFNB1
20poly(i-c)459.3IFNB1, CXCL10, IRF1
21ifn-alpha459.3IFNB1, CXCL10, IRF1
22adenine45 24 1111.3IRF1, CXCL10, IFNB1
23tamoxifen45 51 29 1112.2IRF1, IFNB1, CTRL
24zidovudine45 51 1111.2IFNB1, NEU1, LBR
25pge2459.2IRF1, CXCL10, IFNB1
26adenylate459.1IRF1, CXCL10, IFNB1
27neopterin459.1LBR, CXCL10, IFNB1
28superoxide45 2410.0CTRL, IFNB1, LBR
29chloramphenicol45 3 51 1112.0LBR, IRF1, IFNB1
30progesterone45 29 61 24 1112.9IFNB1, CXCL10, LBR
31purine45 249.9IFNB1, LBR
32estrogen458.9IFNB1, CXCL10, IRF1, NEU1
33cholesterol45 29 24 1111.8IFNB1, CXCL10, LBR
34ribavirin45 51 1110.7IFNB1, CXCL10, NEU1, LBR
35heparin45 29 24 1111.7LBR, NEU1, IFNB1, CTRL
36h2o2458.7LBR, NEU1, IFNB1, CTRL
37cysteine458.6LBR, NEU1, IFNB1, CTRL
38histamine45 29 2410.6LBR, NEU1, CXCL10, CTRL
39genistein45 29 61 3 24 1113.6LBR, CXCL10, IFNB1, CTRL
40dexamethasone45 51 29 1111.6IFNB1, CXCL10, LBR
41arginine458.5CTRL, IRF1, LBR
42rantes458.5IFNB1, CXCL10, IRF1, LBR
43thymidine45 249.5LBR, IRF1, CXCL10, IFNB1
44zinc45 249.5CTRL, IFNB1, IRF1, LBR
45lipid458.4LBR, IRF1, CXCL10, IFNB1
46cycloheximide458.1LBR, NEU1, IRF1, CXCL10, IFNB1
47serine458.1CTRL, IFNB1, IRF1, NEU1, LBR
48tyrosine457.9CTRL, IFNB1, CXCL10, IRF1, LBR
49calcium45 51 24 1110.9LBR, IRF1, CXCL10, IFNB1, CTRL
50retinoic acid45 248.6LBR, NEU1, IRF1, CXCL10, IFNB1, CTRL

GO Terms for genes affiliated with Newcastle Disease

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16Gene Ontology
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Biological processes related to Newcastle Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1type I interferon signaling pathwayGO:0603379.1IFNB1, IRF1
2positive regulation of transcription from RNA polymerase II promoterGO:0459448.9IFNB1, CXCL10, IRF1
3defense response to virusGO:0516078.8IFNB1, CXCL10, IRF1

Products for genes affiliated with Newcastle Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Newcastle Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet