MCID: NCT012
MIFTS: 43

Nicotine Addiction malady

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Summaries for Nicotine Addiction

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MalaCards based summary: Nicotine Addiction is related to lung cancer and neuronitis. An important gene associated with Nicotine Addiction is CHRNA4 (cholinergic receptor, nicotinic, alpha 4 (neuronal)), and among its related pathways are Nicotine Activity on Chromaffin Cells and SIDS Susceptibility Pathways. The compounds rjr 2403 oxalate and sazetidine a dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and testes, and related mouse phenotypes are vision/eye and mortality/aging.

Description from OMIM:46 188890

Aliases & Classifications for Nicotine Addiction

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Nicotine Addiction, Aliases & Descriptions:

Name: Nicotine Addiction 46 62


Related Diseases for Nicotine Addiction

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Graphical network of the top 20 diseases related to Nicotine Addiction:



Diseases related to nicotine addiction

Symptoms for Nicotine Addiction

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Clinical features from OMIM:

188890

Drugs & Therapeutics for Nicotine Addiction

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Drug clinical trials:

Search ClinicalTrials for Nicotine Addiction

Search NIH Clinical Center for Nicotine Addiction

Genetic Tests for Nicotine Addiction

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Anatomical Context for Nicotine Addiction

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MalaCards organs/tissues related to Nicotine Addiction:

32
Lung, Brain, Testes, Cortex, Heart, Cingulate cortex, Amygdala

Animal Models for Nicotine Addiction or affiliated genes

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MGI Mouse Phenotypes related to Nicotine Addiction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.3CHRNB4, CHRNB2, CHRNA9, CHRNA3
2MP:00107688.2GABBR2, GABRD, CHRNA3, CHRNB2, CHRNB4, CHRNA4
3MP:00053777.9CHRNB4, CHRNB2, CHRNA9, GABRD, GABRA6
4MP:00053766.6CHRNA2, CHRNA4, CHRNB4, CHRNB2, CHRNA9, CHRNA3
5MP:00053866.4CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9, CHRNA3
6MP:00036316.0GABRA6, CHRNA2, CHRNA4, CHRNA5, CHRNB4, CHRNB2

Publications for Nicotine Addiction

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Articles related to Nicotine Addiction:

(show top 50)    (show all 240)
idTitleAuthorsYear
1
Finding genomic function for genetic associations in nicotine addiction research: the ENCODE project's role in future pharmacogenomic analysis. (24486638)
2014
2
Where there's smoke there must be ire! Nicotine addiction treatment: a review. (24645304)
2014
3
Molecular mechanisms underlying behaviors related to nicotine addiction. (23143843)
2013
4
Hooked on the nicotine addiction thesis: a response to DiFranza. (24246023)
2013
5
Maternal prenatal depressive symptoms, nicotine addiction, and smoking-related knowledge, attitudes, beliefs, and behaviors. (21607614)
2012
6
The CHRNA5-A3-B4 gene cluster in nicotine addiction. (21968931)
2012
7
Preclinical evidence that activation of mesolimbic alpha 6 subunit containing nicotinic acetylcholine receptors supports nicotine addiction phenotype. (22492084)
2012
8
Optimizing cholinergic tone through lynx modulators of nicotinic receptors: implications for plasticity and nicotine addiction. (22875450)
2012
9
Black and White adults' perspectives on the genetics of nicotine addiction susceptibility. (21406316)
2011
10
A CHRNA5 allele related to nicotine addiction and schizophrenia. (21418140)
2011
11
Smoking and the level of nicotine addiction in relation to the state of hard dental tissues in young adults. (22216822)
2011
12
Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction. (19644963)
2010
13
Nicotine addiction and coronary artery disease: impact of cessation interventions. (20550503)
2010
14
Nicotine addiction in light smoking African American mothers. (20582148)
2010
15
Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction. (20357760)
2010
16
'To prove this is the industry's best hope': big tobacco's support of research on the genetics of nicotine addiction. (20659058)
2010
17
New findings on nicotine addiction and treatment. (19013942)
2009
18
Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. (18834313)
2009
19
Cellular events in nicotine addiction. (19560047)
2009
20
Neurobiology of nicotine addiction: implications for smoking cessation treatment. (18342164)
2008
21
The need to prevent nicotine addiction and diabetes in our youth. The role of school health programs. (17913099)
2007
22
Drug evaluation: CYT-002-NicQb, a therapeutic vaccine for the treatment of nicotine addiction. (17263188)
2007
23
Nicotinic and opioid receptor interactions in nicotine addiction. (17200458)
2006
24
Attention and adolescent tobacco use: A potential self-regulatory dynamic underlying nicotine addiction. (15951129)
2006
25
Pharmacogenetics and nicotine addiction treatment. (16013953)
2005
26
Nicotine addiction through a neurogenomic prism: ethics, public health, and smoking. (16036275)
2005
27
Executive summary: nicotine addiction. (16110349)
2005
28
Executive summary: nicotine addiction. (16215629)
2005
29
Extending the role of associative learning processes in nicotine addiction. (15653812)
2004
30
The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour. (14708004)
2004
31
Treating nicotine addiction. (14670889)
2003
32
The role of nitric oxide in cigarette smoking and nicotine addiction. (12215243)
2002
33
Managing nicotine addiction. (12374267)
2002
34
New directions in the genetic mechanisms underlying nicotine addiction. (11341850)
2001
35
Newly available treatments for nicotine addiction. Smokers wanting help with stopping now have effective treatment options. (11337422)
2001
36
Nicotine addiction. (10669423)
2000
37
A pharmacologic strategy for the treatment of nicotine addiction. (10025686)
1999
38
Individual differences in smoking: gender and nicotine addiction. (11768174)
1999
39
Behavioral and cognitive effects of smoking: relationship to nicotine addiction. (11768172)
1999
40
Neural substrate of nicotine addiction as defined by functional brain maps of gene expression. (9789813)
1998
41
Pharmacology of nicotine: addiction and therapeutics. (8725403)
1996
42
Nicotine addiction. How can we help? (7920054)
1994
43
Cigarette smoking, nicotine addiction, and its pharmacologic treatment. (8422199)
1993
44
The nicotine addiction trap: a 40-year sentence for four cigarettes. (2180512)
1990
45
Nicotine, corticotropin, and smoking withdrawal symptoms: literature review and implications for successful control of nicotine addiction. (2558798)
1989
46
Nicotine addiction. (2592194)
1989
47
Nicotine addiction in the psychiatric hospital: a preliminary report. (3283798)
1988
48
Commentary: coping with nicotine addiction in the psychiatric hospital. (10290274)
1988
49
Nicotine addiction. (480555)
1979
50
Regulation, withdrawal, and nicotine addiction. (111132)
1979

Variations for Nicotine Addiction

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Clinvar genetic disease variations for Nicotine Addiction:

6
id Gene Name Type Significance SNP ID Assembly Location
1GABBR2NM_005458.7(GABBR2): c.360A> G (p.Ala120=)single nucleotide variantrisk factorrs3750344GRCh37Chr 9, 101340316: 101340316
2GABBR2GABABR2, HAPLOTYPE, TATA (rs1435252, rs3780422, rs2779562, rs3750344)undetermined variantrisk factor

Expression for genes affiliated with Nicotine Addiction

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Expression patterns in normal tissues for genes affiliated with Nicotine Addiction

Search GEO for disease gene expression data for Nicotine Addiction.

Pathways for genes affiliated with Nicotine Addiction

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Pathways related to Nicotine Addiction according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CHRNA3, CHRNB4
29.5CHRNB2, CHRNB4, CHRNA4
3
Show member pathways
9.4GABRA6, GABBR2
4
Show member pathways
Nicotine Activity on Dopaminergic Neurons37
8.9CHRNA4, CHRNA5, CHRNB2, CHRNA3
5
Show member pathways
8.9GABRD, GABBR2, GABRA6
68.6GABRA6, GABRD, CHRNB2, CHRNA4
7
Show member pathways
8.1CHRNA3, CHRNA9, CHRNA5, CHRNA4, CHRNA2
8
Show member pathways
7.4CHRNA3, CHRNA9, CHRNB2, CHRNB4, CHRNA5, CHRNA4
97.4CHRNA3, CHRNA9, CHRNB2, CHRNB4, CHRNA5, CHRNA4
10
Show member pathways
7.4CHRNA2, CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9
11
Show member pathways
7.4CHRNA4, CHRNB4, CHRNB2, CHRNA3, GABRD, GABBR2
12
Show member pathways
6.3CHRNA2, CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9
13
Show member pathways
5.8GABRA6, GABBR2, GABRD, CHRNA3, CHRNA9, CHRNB2

Compounds for genes affiliated with Nicotine Addiction

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Compounds related to Nicotine Addiction according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1rjr 2403 oxalate6110.3CHRNA4, CHRNB2
2sazetidine a dihydrochloride6110.3CHRNA4, CHRNB2
3varenicline tartrate6110.3CHRNA4, CHRNB2
4(-)-nicotine ditartrate6110.3CHRNA4, CHRNB2
5desformylflustrabromine hydrochloride6110.3CHRNA4, CHRNB2
6ly2087101 2810.1CHRNA2, CHRNA4
7ns1738 2810.1CHRNA4, CHRNA3
8a-867744 2810.0CHRNA4, CHRNA3
9varenicline44 1111.0CHRNA3, CHRNA4
10alpha-conotoxin txia289.9CHRNA3, CHRNA5
11alpha-conotoxin-gic289.9CHRNA3, CHRNA5
12alpha-conotoxin pnia289.9CHRNA3, CHRNA5
13alpha-conotoxin mii289.9CHRNA5, CHRNA3
14dextromethorphan2 50 24 1112.9CHRNA2, CYP2A6
15drugs used in nicotine dependence509.9CHRNA5, CHRNA3
16diazepam44 28 50 1112.7GABRD, CYP2A6
17primidone44 1110.7GABRA6, CHRNA4
18thiopental44 1110.7GABRA6, CHRNA4
19pentobarbital44 1110.6GABRA6, CHRNA4
20flunitrazepam28 44 1111.6CYP2A6, GABRA6
21[3h]cytisine289.6CHRNA2, CHRNA4, CHRNA3
22[125i]epibatidine289.6CHRNA2, CHRNA4, CHRNA3
23[3h]epibatidine289.6CHRNA3, CHRNA4, CHRNA2
24mecamylamine44 28 1111.6CHRNA2, CHRNA4, CHRNA3
25hexamethonium44 2810.6CHRNA3, CHRNA4, CHRNA2
26thip289.5GABRD, GABRA6
27(+)-bicuculline619.5GABRD, GABRA6
28(-)-bicuculline methochloride619.5GABRD, GABRA6
29(-)-bicuculline methiodide619.5GABRD, GABRA6
30sr 95531 hydrobromide619.5GABRD, GABRA6
31bupropion50 44 24 1112.5CYP2A6, CHRNA3
32amobarbital44 1110.5CYP2A6, CHRNA4, GABRA6
33hexobarbital44 1110.5GABRA6, CHRNA4, CYP2A6
34nitrazepam44 1110.5GABRD, GABRA6
35bromazepam44 1110.4GABRD, GABRA6
36lorazepam44 50 1111.4GABRA6, GABRD
37chlordiazepoxide44 1110.4GABRA6, GABRD
38phenobarbital44 28 50 1112.4GABRA6, CHRNA4, CYP2A6
39oxazepam50 1110.4GABRA6, GABRD
40tbps44 2810.3GABRD, GABRA6
41Gamma-Aminobutyric acid249.3GABRD, GABBR2, GABRA6
42muscimol44 61 2811.3GABRA6, GABRD
43flurazepam44 1110.3CYP2A6, GABRD, GABRA6
44alprazolam44 1110.3GABRA6, GABRD, CYP2A6
45triazolam44 1110.3GABRA6, GABRD
46midazolam44 50 1111.2GABRA6, GABRD, CYP2A6
47clobazam44 50 1111.2GABRD, GABRA6
48acetylcholine44 50 28 24 1113.1CHRNA3, CHRNB2, CHRNA4
49galantamine44 50 119.9CHRNA2, CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9
50nicotine44 28 50 1110.5CHRNA3, CYP2A6, CHRNA9, CHRNB2, CHRNB4, CHRNA5

GO Terms for genes affiliated with Nicotine Addiction

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Cellular components related to Nicotine Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chloride channel complexGO:0347078.9GABRD, GABRA6
2integral component of plasma membraneGO:0058878.5GABRA6, GABBR2, GABRD, CHRNB4
3acetylcholine-gated channel complexGO:0058927.5CHRNA2, CHRNA3, CHRNA9, CHRNB2, CHRNB4, CHRNA5
4plasma membraneGO:0058866.2CHRNA2, CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9
5postsynaptic membraneGO:0452115.9CHRNB2, CHRNB4, CHRNA5, CHRNA4, CHRNA2, CHRNA9
6cell junctionGO:0300545.8GABRA6, GABBR2, GABRD, CHRNA3, CHRNA9, CHRNB2

Biological processes related to Nicotine Addiction according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1neurological system processGO:05087710.2CHRNA4, CHRNB2
2regulation of dopamine secretionGO:01405910.2CHRNA4, CHRNB2
3membrane depolarizationGO:05189910.1CHRNA4, CHRNB2
4cognitionGO:05089010.0CHRNB2, CHRNA4
5smooth muscle contractionGO:00693910.0CHRNB2, CHRNB4
6response to nicotineGO:03509410.0CHRNB2, CHRNA4
7B cell activationGO:04211310.0CHRNB2, CHRNA4
8regulation of dendrite morphogenesisGO:0488149.9CHRNB2, CHRNA3
9sensory perception of painGO:0192339.9CHRNB2, CHRNA4
10calcium ion transportGO:0068169.9CHRNB2, CHRNA4
11regulation of smooth muscle contractionGO:0069409.9CHRNA3, CHRNB4
12action potentialGO:0015089.8CHRNB2, CHRNB4, CHRNA4
13synaptic transmission involved in micturitionGO:0600849.6CHRNB4, CHRNB2, CHRNA3
14gamma-aminobutyric acid signaling pathwayGO:0072149.6GABBR2, GABRA6
15protein heterooligomerizationGO:0512919.5CHRNB2, CHRNA2
16regulation of membrane potentialGO:0423919.4CHRNA3, CHRNA4
17synaptic transmission, cholinergicGO:0072719.3CHRNA4, CHRNB4, CHRNB2, CHRNA3
18locomotory behaviorGO:0076269.3CHRNA4, CHRNB4, CHRNB2, CHRNA3
19cation transportGO:0068129.0CHRNA3, CHRNB4, CHRNA5, CHRNA2
20behavioral response to nicotineGO:0350958.9CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA3
21transportGO:0068108.9CHRNA5, GABRD, GABRA6
22ion transportGO:0068118.8CHRNA2, CHRNA4, CHRNB4, CHRNB2, CHRNA3
23ion transmembrane transportGO:0342208.1CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA3, GABRA6
24signal transductionGO:0071657.1CHRNA2, CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA3
25synaptic transmissionGO:0072686.2GABRA6, CHRNA2, CHRNA4, CHRNA5, CHRNB4, CHRNB2

Molecular functions related to Nicotine Addiction according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.6CHRNB2, CHRNA2
2GABA-A receptor activityGO:0048909.2GABRD, GABRA6
3extracellular ligand-gated ion channel activityGO:0052309.1GABRA6, GABRD
4chloride channel activityGO:0052548.9GABRA6, GABRD
5acetylcholine bindingGO:0421668.9CHRNA3, CHRNB2, CHRNA4, CHRNA2
6ligand-gated ion channel activityGO:0152768.7CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA3
7acetylcholine receptor activityGO:0154648.2CHRNA2, CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA3
8acetylcholine-activated cation-selective channel activityGO:0048897.6CHRNA3, CHRNA2, CHRNA4, CHRNA5, CHRNB4, CHRNB2

Products for genes affiliated with Nicotine Addiction

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Sources for Nicotine Addiction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet