MCID: NCT012
MIFTS: 42

Nicotine Addiction malady

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Summaries for Nicotine Addiction

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47OMIM, 33MalaCards
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MalaCards: Nicotine Addiction, also known as nicotine dependence, is related to lung cancer and neuronitis. An important gene associated with Nicotine Addiction is CHRNA4 (cholinergic receptor, nicotinic, alpha 4 (neuronal)), and among its related pathways are SIDS Susceptibility Pathways and Nicotine Activity on Chromaffin Cells. The compounds (-)-nicotine ditartrate and varenicline tartrate have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and testes, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Description from OMIM:47 188890

Aliases & Classifications for Nicotine Addiction

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62UMLS, 47OMIM
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Aliases & Descriptions:

nicotine addiction 47
nicotine dependence 62


Related Diseases for Nicotine Addiction

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Nicotine Addiction:



Diseases related to nicotine addiction

Symptoms for Nicotine Addiction

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47OMIM
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Clinical features from OMIM:

188890

Drugs & Therapeutics for Nicotine Addiction

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Nicotine Addiction

Search NIH Clinical Center for Nicotine Addiction

Genetic Tests for Nicotine Addiction

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Anatomical Context for Nicotine Addiction

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33MalaCards
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MalaCards organs/tissues related to Nicotine Addiction:

33
Lung, Brain, Testes, Cortex, Heart, Cingulate cortex, Amygdala

Animal Models for Nicotine Addiction or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Nicotine Addiction:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.6GABRD, CHRNA9, CHRNB2, CHRNB4
2MP:00053918.3CHRNB4, CHRNB2, CHRNA9, CHRNA3
3MP:00107687.9GABRD, CHRNA3, CHRNB2, CHRNB4, CHRNA4
4MP:00053877.9CHRNA3, CHRNA9, CHRNB2, CHRNB4, CHRNA4
5MP:00053767.7CHRNA4, CHRNB4, CHRNB2, CHRNA9, CHRNA3
6MP:00053867.0GABRD, CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9
7MP:00036316.9CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9, CHRNA3

Publications for Nicotine Addiction

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52PubMed
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Articles related to Nicotine Addiction:

(show top 50)    (show all 232)
idTitleAuthorsYear
1
Molecular mechanisms underlying behaviors related to nicotine addiction. (23143843)
2013
2
Hooked on the nicotine addiction thesis: a response to DiFranza. (24246023)
2013
3
Maternal prenatal depressive symptoms, nicotine addiction, and smoking-related knowledge, attitudes, beliefs, and behaviors. (21607614)
2012
4
The CHRNA5-A3-B4 gene cluster in nicotine addiction. (21968931)
2012
5
Preclinical evidence that activation of mesolimbic alpha 6 subunit containing nicotinic acetylcholine receptors supports nicotine addiction phenotype. (22492084)
2012
6
Optimizing cholinergic tone through lynx modulators of nicotinic receptors: implications for plasticity and nicotine addiction. (22875450)
2012
7
Black and White adults' perspectives on the genetics of nicotine addiction susceptibility. (21406316)
2011
8
A CHRNA5 allele related to nicotine addiction and schizophrenia. (21418140)
2011
9
Smoking and the level of nicotine addiction in relation to the state of hard dental tissues in young adults. (22216822)
2011
10
Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction. (19644963)
2010
11
Nicotine addiction and coronary artery disease: impact of cessation interventions. (20550503)
2010
12
Nicotine addiction in light smoking African American mothers. (20582148)
2010
13
Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction. (20357760)
2010
14
'To prove this is the industry's best hope': big tobacco's support of research on the genetics of nicotine addiction. (20659058)
2010
15
New findings on nicotine addiction and treatment. (19013942)
2009
16
Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. (18834313)
2009
17
Cellular events in nicotine addiction. (19560047)
2009
18
Neurobiology of nicotine addiction: implications for smoking cessation treatment. (18342164)
2008
19
The need to prevent nicotine addiction and diabetes in our youth. The role of school health programs. (17913099)
2007
20
Drug evaluation: CYT-002-NicQb, a therapeutic vaccine for the treatment of nicotine addiction. (17263188)
2007
21
Nicotinic and opioid receptor interactions in nicotine addiction. (17200458)
2006
22
Attention and adolescent tobacco use: A potential self-regulatory dynamic underlying nicotine addiction. (15951129)
2006
23
Pharmacogenetics and nicotine addiction treatment. (16013953)
2005
24
Nicotine addiction through a neurogenomic prism: ethics, public health, and smoking. (16036275)
2005
25
Executive summary: nicotine addiction. (16110349)
2005
26
Executive summary: nicotine addiction. (16215629)
2005
27
Extending the role of associative learning processes in nicotine addiction. (15653812)
2004
28
The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour. (14708004)
2004
29
Treating nicotine addiction. (14670889)
2003
30
The role of nitric oxide in cigarette smoking and nicotine addiction. (12215243)
2002
31
Managing nicotine addiction. (12374267)
2002
32
Nicotine addiction, young adults, and smoke-free bars. (12188987)
2002
33
New directions in the genetic mechanisms underlying nicotine addiction. (11341850)
2001
34
Newly available treatments for nicotine addiction. Smokers wanting help with stopping now have effective treatment options. (11337422)
2001
35
Nicotine addiction. (10669423)
2000
36
A pharmacologic strategy for the treatment of nicotine addiction. (10025686)
1999
37
Individual differences in smoking: gender and nicotine addiction. (11768174)
1999
38
Behavioral and cognitive effects of smoking: relationship to nicotine addiction. (11768172)
1999
39
Prevention of nicotine addiction: neuropsychopharmacological issues. (11072403)
1999
40
Neural substrate of nicotine addiction as defined by functional brain maps of gene expression. (9789813)
1998
41
Pharmacology of nicotine: addiction and therapeutics. (8725403)
1996
42
Nicotine addiction. How can we help? (7920054)
1994
43
Cigarette smoking, nicotine addiction, and its pharmacologic treatment. (8422199)
1993
44
The nicotine addiction trap: a 40-year sentence for four cigarettes. (2180512)
1990
45
Nicotine, corticotropin, and smoking withdrawal symptoms: literature review and implications for successful control of nicotine addiction. (2558798)
1989
46
Nicotine addiction. (2592194)
1989
47
Nicotine addiction in the psychiatric hospital: a preliminary report. (3283798)
1988
48
Commentary: coping with nicotine addiction in the psychiatric hospital. (10290274)
1988
49
Nicotine addiction. (480555)
1979
50
Regulation, withdrawal, and nicotine addiction. (111132)
1979

Variations for Nicotine Addiction

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Expression for genes affiliated with Nicotine Addiction

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nicotine Addiction

Search GEO for disease gene expression data for Nicotine Addiction.

Pathways for genes affiliated with Nicotine Addiction

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Sources:
50PathCards, 38NCBI BioSystems Database, 51PharmGKB, 30KEGG, 53QIAGEN, 12EMD Millipore, 55Reactome
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Pathways related to Nicotine Addiction according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CHRNB2, CHRNB4, CHRNA4
2
Show member pathways
9.2CHRNA3, CHRNB4
39.1CHRNA4, CHRNB2, GABRD
4
Show member pathways
Nicotine Activity on Dopaminergic Neurons38
8.4CHRNA4, CHRNA5, CHRNB2, CHRNA3
5
Show member pathways
8.3CHRNA4, CHRNA5, CHRNA9, CHRNA3
6
Show member pathways
7.9GABRD, CHRNA3, CHRNB2, CHRNB4, CHRNA4
77.4CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9, CHRNA3
8
Show member pathways
7.4CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9, CHRNA3
9
Show member pathways
7.4CHRNA3, CHRNA9, CHRNB2, CHRNB4, CHRNA5, CHRNA4
10
Show member pathways
7.4CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9, CHRNA3
11
Show member pathways
6.8CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9, CHRNA3

Compounds for genes affiliated with Nicotine Addiction

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Sources:
61Tocris Bioscience, 45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 24HMDB
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Compounds related to Nicotine Addiction according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1(-)-nicotine ditartrate6110.1CHRNA4, CHRNB2
2varenicline tartrate6110.1CHRNB2, CHRNA4
3sazetidine a dihydrochloride6110.1CHRNB2, CHRNA4
4rjr 2403 oxalate6110.1CHRNB2, CHRNA4
5desformylflustrabromine hydrochloride6110.1CHRNA4, CHRNB2
6amobarbital45 1110.9CHRNA4, CYP2A6
7hexobarbital45 1110.9CYP2A6, CHRNA4
8phenobarbital45 29 51 1112.7CHRNA4, CYP2A6
9ns1738 299.6CHRNA4, CHRNA3
10[3h]cytisine299.6CHRNA4, CHRNA3
11a-867744 299.6CHRNA4, CHRNA3
12[125i]epibatidine299.6CHRNA4, CHRNA3
13flurazepam45 1110.6GABRD, CYP2A6
14[3h]epibatidine299.6CHRNA4, CHRNA3
15varenicline45 1110.6CHRNA4, CHRNA3
16mecamylamine45 29 1111.5CHRNA3, CHRNA4
17hexamethonium45 2910.5CHRNA3, CHRNA4
18alprazolam45 1110.5GABRD, CYP2A6
19alpha-conotoxin txia299.5CHRNA3, CHRNA5
20alpha-conotoxin-gic299.5CHRNA3, CHRNA5
21alpha-conotoxin pnia299.5CHRNA3, CHRNA5
22alpha-conotoxin mii299.5CHRNA5, CHRNA3
23drugs used in nicotine dependence519.4CHRNA5, CHRNA3
24bupropion51 45 24 1112.4CHRNA3, CYP2A6
25midazolam45 51 1111.3GABRD, CYP2A6
26diazepam45 29 51 1112.1GABRD, CYP2A6
27acetylcholine45 51 29 24 1112.9CHRNA4, CHRNB2, CHRNA3
28galantamine45 51 119.8CHRNA3, CHRNA9, CHRNB2, CHRNB4, CHRNA5, CHRNA4
29nicotine45 29 51 1110.4CYP2A6, CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9

GO Terms for genes affiliated with Nicotine Addiction

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16Gene Ontology
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Cellular components related to Nicotine Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:0058927.4CHRNA3, CHRNA9, CHRNB2, CHRNB4, CHRNA5, CHRNA4
2plasma membraneGO:0058867.4CHRNA3, CHRNA9, CHRNB2, CHRNB4, CHRNA5, CHRNA4
3postsynaptic membraneGO:0452116.7CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9, CHRNA3
4cell junctionGO:0300546.5CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9, CHRNA3

Biological processes related to Nicotine Addiction according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1neurological system processGO:05087710.0CHRNA4, CHRNB2
2regulation of dopamine secretionGO:01405910.0CHRNA4, CHRNB2
3membrane depolarizationGO:0518999.9CHRNB2, CHRNA4
4cognitionGO:0508909.9CHRNB2, CHRNA4
5response to nicotineGO:0350949.9CHRNB2, CHRNA4
6smooth muscle contractionGO:0069399.8CHRNB4, CHRNB2
7B cell activationGO:0421139.8CHRNA4, CHRNB2
8sensory perception of painGO:0192339.8CHRNB2, CHRNA4
9response to hypoxiaGO:0016669.8CHRNB2, CHRNA4
10action potentialGO:0015089.6CHRNA4, CHRNB4, CHRNB2
11regulation of dendrite morphogenesisGO:0488149.5CHRNA3, CHRNB2
12calcium ion transportGO:0068169.5CHRNB2, CHRNA4
13regulation of smooth muscle contractionGO:0069409.4CHRNA3, CHRNB4
14regulation of membrane potentialGO:0423919.2CHRNA3, CHRNA4
15synaptic transmission involved in micturitionGO:0600849.2CHRNB4, CHRNB2, CHRNA3
16cation transportGO:0068129.0CHRNA5, CHRNB4, CHRNA3
17synaptic transmission, cholinergicGO:0072718.8CHRNA3, CHRNB2, CHRNB4, CHRNA4
18locomotory behaviorGO:0076268.8CHRNA4, CHRNB4, CHRNB2, CHRNA3
19ion transportGO:0068118.8CHRNA3, CHRNB2, CHRNB4, CHRNA4
20behavioral response to nicotineGO:0350958.3CHRNA3, CHRNB2, CHRNB4, CHRNA5, CHRNA4
21ion transmembrane transportGO:0342208.3CHRNA3, CHRNB2, CHRNB4, CHRNA5, CHRNA4
22signal transductionGO:0071657.6GABRD, CHRNA3, CHRNB2, CHRNB4, CHRNA5, CHRNA4
23synaptic transmissionGO:0072687.2CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9, CHRNA3

Molecular functions related to Nicotine Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine bindingGO:0421668.9CHRNA3, CHRNB2, CHRNA4
2ligand-gated ion channel activityGO:0152767.9CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA3
3acetylcholine receptor activityGO:0154647.7CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA3
4acetylcholine-activated cation-selective channel activityGO:0048897.4CHRNA3, CHRNA4, CHRNA5, CHRNB4, CHRNB2, CHRNA9

Products for genes affiliated with Nicotine Addiction

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Sources for Nicotine Addiction

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet