MCID: NCT012
MIFTS: 48

Nicotine Addiction malady

Summaries for Nicotine Addiction

Sources:
47OMIM, 33MalaCards
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MalaCards: Nicotine Addiction, also known as nicotine dependence, is related to nicotine dependence and alcohol dependence. An important gene associated with Nicotine Addiction is CHRNA4 (cholinergic receptor, nicotinic, alpha 4 (neuronal)), and among its related pathways are Nicotine Activity on Chromaffin Cells and SIDS Susceptibility Pathways. The compounds α-conotoxin mii and amobarbital have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related mouse phenotypes are digestive/alimentary and muscle.

Description from OMIM:47 188890

Aliases & Classifications for Nicotine Addiction

Sources:
61UMLS, 47OMIM
See all sources

Aliases & Descriptions:

nicotine addiction 47
nicotine dependence 61


Related Diseases for Nicotine Addiction

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Nicotine Addiction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1nicotine dependence32.0CHRNA3, CHRNA4, CHRNA6, CYP2A6, CHRNB4, CHRNB2
2alcohol dependence31.1GABRA2, GABRA6, DRD2, CNR1, CHRM2, CHRNB4
3substance abuse30.6CNR1, DRD2
4drug addiction30.6ABAT, HCRT, NTS, DRD2
5cannabis dependence30.6GABRA2, CNR1
6cocaine dependence30.6CHRNB4, DRD2, CHRNA3, CHRNA5
7substance dependence30.5CNR1, DRD2
8panic disorder30.4ABAT
9bipolar disorder30.2CNR1, DRD2
10major depressive disorder30.2CHRM2
11parkinson's disease30.0HCRT, DRD2, CHRNA4, NTS, CNR1
12anxiety disorder10.4
13coronary artery disease,10.3
14lung cancer susceptibility10.3
15nicotine addiction, protection from10.3
16attention deficit hyperactivity disorder10.3
17pathological gambling10.2
18asthma10.2
19wisconsin syndrome10.2
20nicotine dependence, protection against10.2
21alcohol abuse10.1
22n syndrome10.1
23brain disease10.1
24hypersomnia10.1
25peripheral vascular disease10.0
26bruxism10.0
27conduct disorder10.0
28thromboangiitis obliterans10.0
29combat disorder10.0
30vascular disease10.0
31chronic pain10.0
32insomnia10.0
33neuroblastoma10.0NTS
34dementia10.0HCRT
35schizoaffective disorder10.0DRD2
36anorexia nervosa10.0HCRT, CNR1
37lung cancer susceptibility 210.0CHRNA3, CHRNA5
38focal epilepsy10.0CHRNA4, CHRNB2
39autosomal dominant nocturnal frontal lobe epilepsy10.0CHRNA4, CHRNB2
40narcolepsy10.0HCRT, DRD2
41drug dependence10.0CNR1, DRD2, CHRM2
42pulmonary disease, chronic obstructive10.0CHRNA3, CHRNA5
43restless legs syndrome10.0HCRT, DRD2
44eating disorder10.0HCRT, CNR1, NTS
45pain agnosia10.0NTS, CHRNA4, CNR1
46idiopathic generalized epilepsy10.0GABRD, CHRNA4
47amyotrophic lateral sclerosis10.0CNR1
48migraine10.0CHRM2, DRD2, HCRT, CNR1
49psychotic disorder10.0CNR1, NTS, DRD2
50epilepsy syndrome10.0NTS, CHRNA4, CHRNB2, ABAT, CNR1

Graphical network of the top 20 diseases related to Nicotine Addiction:



Diseases related to nicotine addiction

Clinical Features for Nicotine Addiction

Sources:
47OMIM
See all sources

Clinical features from OMIM:

188890

Drugs & Therapeutics for Nicotine Addiction

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Nicotine Addiction

Drug clinical trials:

Search ClinicalTrials for Nicotine Addiction

Search NIH Clinical Center for Nicotine Addiction

Search CenterWatch for Nicotine Addiction

Genetic Tests for Nicotine Addiction

Anatomical Context for Nicotine Addiction

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Nicotine Addiction:

33
Brain, Cortex, Heart, Lung, Cingulate cortex, Amygdala

Animal Models for Nicotine Addiction or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Nicotine Addiction

Sources:
51PubMed
See all sources

Articles related to Nicotine Addiction:

(show top 50)    (show all 240)
idTitleAuthorsYear
1
Molecular mechanisms underlying behaviors related to nicotine addiction. (23143843)
2013
2
Modeling Complexity of EMA Data: Time-Varying Lagged Effects of Negative Affect on Smoking Urges for Subgroups of Nicotine Addiction. (23911846)
2013
3
THC reduces the anticipatory nucleus accumbens response to reward in subjects with a nicotine addiction. (23443360)
2013
4
The brain activations for both cue-induced gaming urge and smoking craving among subjects comorbid with Internet gaming addiction and nicotine dependence. (23245948)
2013
5
Maternal prenatal depressive symptoms, nicotine addiction, and smoking-related knowledge, attitudes, beliefs, and behaviors. (21607614)
2012
6
Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutations. (22885704)
2012
7
At the twisted heart of nicotine addiction. (22684837)
2012
8
Developing a Rational Approach to Tobacco Use Treatment in Pulmonary Practice: A Review of the Biological Basis of Nicotine Addiction. (22707873)
2012
9
Smoking family, secondhand smoke exposure at home, and nicotine addiction among adolescent smokers. (22406053)
2012
10
Adolescent obesity as a risk factor for high-level nicotine addiction in young women. (22018566)
2011
11
Nicotine addiction and coronary artery disease: impact of cessation interventions. (20550503)
2010
12
Nicotine addiction in light smoking African American mothers. (20582148)
2010
13
Nicotine addiction and nicotinic receptors: lessons from genetically modified mice. (20485364)
2010
14
A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction. (20643934)
2010
15
Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction. (20299008)
2010
16
Tobacco control and nicotine addiction in Canada: current trends, management and challenges. (19262909)
2009
17
A tragic triad: coronary artery disease, nicotine addiction, and depression. (19550307)
2009
18
Associative learning, the hippocampus, and nicotine addiction. (19630701)
2008
19
A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. (18618000)
2008
20
It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. (18242816)
2008
21
Nicotine addiction: past, present and future. Marian Fischman lecture given at the 2007 meeting of CPDD. (18286705)
2008
22
Nicotine addiction. (18765487)
2008
23
Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD). (17727820)
2007
24
The decline in lung cancer and the genetics of nicotine addiction. (17476817)
2007
25
Attention and adolescent tobacco use: A potential self-regulatory dynamic underlying nicotine addiction. (15951129)
2006
26
Occupancy of dopamine D2 receptors by antipsychotic drugs is related to nicotine addiction in young patients with schizophrenia. (16292589)
2006
27
Executive summary: nicotine addiction. (16215629)
2005
28
The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour. (14708004)
2004
29
Role of nicotine pharmacokinetics in nicotine addiction and nicotine replacement therapy: a review. (12971663)
2003
30
The future of the nicotine-addiction market. (13678968)
2003
31
Nicotine addiction: the possible role of functional upregulation. (11879680)
2002
32
Cellular and synaptic mechanisms of nicotine addiction. (12436424)
2002
33
Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics. (11978809)
2002
34
New directions in the genetic mechanisms underlying nicotine addiction. (11341850)
2001
35
Forum. Which aspects of nicotine addiction should concern mental health professionials? (10402317)
1999
36
Nicotine addiction. (10436290)
1999
37
Nicotine addiction: a pediatric disease. (9108846)
1997
38
Smoking and nicotine addiction: a pediatric epidemic with sequelae in adulthood. (9360824)
1997
39
Pharmacology of nicotine: addiction and therapeutics. (8725403)
1996
40
Nicotine addiction. (8850203)
1996
41
Nicotine addiction in young people. (7791824)
1995
42
From the Centers for Disease Control and Prevention. Indicators of nicotine addiction among women--United States, 1991-1992. (7869545)
1995
43
The nicotine addiction trap: a 40-year sentence for four cigarettes. (2180512)
1990
44
Understanding nicotine addiction and intervention techniques for the dental professional. (2289588)
1990
45
Affect regulation, nicotine addiction, and smoking cessation. (2681631)
1989
46
Nicotine addiction in the psychiatric hospital: a preliminary report. (3283798)
1988
47
Nicotine addiction? (3176443)
1988
48
Nicotine addiction. (480555)
1979
49
Nicotine addiction: treatment with medical hypnosis. Part 2. (722107)
1978
50
Letter: Treatment of nicotine addiction with Avena sativa. (4471694)
1974

Genetic Variations for Nicotine Addiction

Expression for genes affiliated with Nicotine Addiction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Nicotine Addiction

Search GEO for disease gene expression data for Nicotine Addiction.

Pathways for genes affiliated with Nicotine Addiction

Sources:
38NCBI BioSystems Database, 50PharmGKB, 52QIAGEN, 54Reactome, 12EMD Millipore, 53R&D Systems, 60Tocris Bioscience, 30KEGG
See all sources

Pathways related to Nicotine Addiction according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3CHRNA3, CHRNB4
210.2CHRNB2, CHRNB4, CHRNA4, CHRM2
3
Hide members
10.1GABRA2, GABRA6, GABRD, GABRQ
4
Hide members
10.1GABRQ, GABRD, GABRA6, GABRA2
5
Hide members
10.1GABRQ, GABRD, GABRA6, GABRA2
6
Hide members
10.1CHRNB2, CHRNB4, CHRNA3, CHRNA6, CHRNA4, CHRNA5
710.1CHRNB2, CHRNB4, CHRNA3, CHRNA6, CHRNA4, CHRNA5
8
Hide members
10.1CHRNB2, CHRNB4, CHRNA3, CHRNA6, CHRNA4, CHRNA5
9
Hide members
10.0DRD2, CHRNB2, CHRNA3, CHRNA6, CHRNA4, CHRNA5
10
Hide members
9.7GABRA6, GABRA2, CHRNB2, CHRNB4, CHRNA3, CHRNA6
119.7GABRQ, GABRD, GABRA6, GABRA2, CHRNB2, CHRNA6
12
Hide members
9.2GABRD, GABRA6, GABRA2, CHRNB2, CHRNB4, CHRNA3
13
Hide members
9.2CHRNA6, CHRNA4, CHRM2, CHRNA5, GRIN3B, NTS

Compounds for genes affiliated with Nicotine Addiction

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to Nicotine Addiction according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1α-conotoxin mii2910.6CHRNA6, CHRNA3, CHRNA5
2amobarbital45 1111.6CHRNA4, GABRA6, CYP2A6, GABRA2
3varenicline45 1111.6CHRNA4, CHRNA6, CHRNA3
4hexobarbital45 1111.6GABRA6, CYP2A6, CHRNA4, GABRA2
5mecamylamine29 45 1112.6CHRNA4, CHRNA3, CHRNA6
6pentobarbital45 1111.6HCRT, GABRA2, CHRNA4, GABRA6
7Barbituric acid derivative1110.5CHRNA4, GABRA2, GABRA6
8amphetamine45 1111.5HCRT, CNR1, DRD2, CYP2A6, NTS
9sr 95531 hydrobromide6010.5GABRQ, GABRD, GABRA6, GABRA2
10Talbutal1110.5GABRA6, CHRNA4, GABRA2
11(+)-bicuculline6010.5GABRQ, GABRA2, GABRA6, GABRD
12bupropion45 50 11 2413.5CNR1, CYP2A6, DRD2, CHRNA3
13(-)-bicuculline methiodide6010.5GABRA6, GABRA2, GABRD, GABRQ
14(-)-bicuculline methochloride6010.5GABRA2, GABRA6, GABRQ, GABRD
15Butalbital1110.5CHRNA4, GABRA2, GABRA6
16galantamine45 50 1112.5CHRNA4, CHRNA6, CHRNA3, CHRNB4, CHRNB2, CHRNA5
17Clorazepate1110.5GABRQ, GABRD, GABRA6, GABRA2
18Heptabarbital1110.5CHRNA4, GABRA2, GABRA6
19bromazepam45 1111.5GABRQ, GABRD, GABRA6, GABRA2
20nitrazepam45 1111.5GABRA2, GABRA6, GABRD, GABRQ
21flurazepam45 1111.5GABRQ, CYP2A6, GABRA2, GABRD, GABRA6
22Temazepam1110.5GABRQ, GABRD, GABRA2, GABRA6
23alprazolam45 1111.5GABRD, GABRQ, GABRA6, GABRA2, CYP2A6
24Metharbital1110.5CHRNA4, GABRA2, GABRA6
25chlordiazepoxide45 1111.5GABRQ, GABRD, GABRA6, GABRA2
26diazepam45 50 29 1113.5GABRA2, GABRD, GABRQ, CYP2A6, ABAT
27midazolam45 50 1112.5GABRA6, GABRQ, GABRA2, CYP2A6, GABRD
28oxazepam50 1111.5GABRA2, GABRA6, GABRD, GABRQ
29lorazepam45 50 1112.5GABRA2, GABRQ, DRD2, GABRD, GABRA6
30clobazam45 50 1112.5GABRD, GABRA6, GABRQ, GABRA2
31Butethal1110.5GABRA6, GABRA2, CHRNA4
32tbps45 2911.5GABRD, GABRA6, GABRA2, GABRQ
33triazolam45 1111.5GABRQ, GABRD, GABRA6, GABRA2
34nmda45 2911.5SLC32A1, HCRT, GRIN3B, CNR1
35Barbital1110.4GABRA2, CHRNA4, GABRA6
36cocaine45 1111.4CNR1, HCRT, NTS, CHRM2, DRD2, ABAT
37Aprobarbital1110.4GABRA6, GABRA2, CHRNA4
38muscimol45 60 2912.4GABRA6, GABRQ, GABRA2, HCRT, ABAT, GABRD
395-hydroxytryptamine4510.4DRD2, CNR1, HCRT, NTS, CHRM2
40thip2910.4GABRD, GABRA6, GABRA2
41Butabarbital1110.4CHRNA4, GABRA6, GABRA2
42hexamethonium45 2911.3CHRNA4, CHRNA6, CHRNA3
43dopamine45 29 11 2413.3SLC32A1, HCRT, CNR1, CYP2A6, ABAT, CHRNA4
44gaba4510.3ABAT, CNR1, HCRT, NTS, GABRA6, DRD2
45acetylcholine45 50 29 11 2414.3CHRM2, CHRNA3, HCRT, CNR1, NTS, DRD2
46Methylphenobarbital1110.2CHRNA4, GABRA6, GABRA2
47opiate4510.2DRD2, CHRM2, HCRT, NTS
48Secobarbital1110.1GABRA2, GABRA6, CHRNA4
49nicotine45 50 29 1113.0CHRNB4, NTS, CHRNA5, CHRM2, CHRNA4, CHRNA6
50tetrodotoxin45 60 2911.9HCRT, NTS, CNR1, CHRM2

GO Terms for genes affiliated with Nicotine Addiction

Sources:
16Gene Ontology
See all sources

Cellular components related to Nicotine Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:03042510.2SLC32A1, CHRNA4, CHRNA3, DRD2
2acetylcholine-gated channel complexGO:00589210.1CHRNB2, CHRNB4, CHRNA3, CHRNA6, CHRNA4, CHRNA5
3chloride channel complexGO:03470710.0GABRQ, GABRD, GABRA6, GABRA2
4postsynaptic membraneGO:0452119.6CHRNA5, CHRM2, CHRNA4, CHRNA6, CHRNA3, CHRNB4
5integral to plasma membraneGO:0058879.6DRD2, GABRQ, GABRD, GABRA6, CHRNB4, CHRM2
6cell junctionGO:0300549.6HCRT, GABRQ, GRIN3B, CHRNA5, CHRM2, CHRNA4
7plasma membraneGO:0058869.5DRD2, GABRA6, GABRA2, CHRNB2, CHRNB4, CHRNA3

Biological processes related to Nicotine Addiction according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of action potentialGO:04575910.7CHRNB2, CNR1
2synaptic transmission involved in micturitionGO:06008410.6CHRNA3, CHRNB4, CHRNB2
3neurological system processGO:05087710.6CHRNA4, CHRNB2
4regulation of synaptic transmission, GABAergicGO:03222810.6CNR1, DRD2
5membrane depolarizationGO:05189910.6CHRNB2, CHRNA6, CHRNA4
6response to cocaineGO:04222010.6DRD2, CHRNB2, CNR1
7synaptic transmission, cholinergicGO:00727110.6CHRNB2, CHRNB4, CHRNA3, CHRNA4
8sensory perception of painGO:01923310.6CHRNB2, CHRNA4, CNR1
9negative regulation of blood pressureGO:04577610.6ABAT, CNR1, DRD2
10behavioral response to cocaineGO:04814810.6DRD2, ABAT
11regulation of dopamine secretionGO:01405910.5DRD2, CHRNB2, CHRNA6, CHRNA4
12regulation of smooth muscle contractionGO:00694010.5CHRNB4, CHRNA3
13behavioral response to nicotineGO:03509510.5CHRNB2, CHRNB4, CHRNA3, CHRNA4, CHRNA5
14response to iron ionGO:01003910.5DRD2, ABAT
15response to ethanolGO:04547110.5CHRNB2, CNR1, ABAT
16regulation of neurotransmitter secretionGO:04692810.5HCRT, CHRNB4
17response to nicotineGO:03509410.5DRD2, CHRNB2, CHRNA4, CNR1, ABAT
18response to hypoxiaGO:00166610.5ABAT, CHRNA4, CHRNB2, DRD2
19ion transportGO:00681110.5CHRNB2, CHRNB4, CHRNA3, CHRNA4, SLC32A1
20regulation of action potentialGO:00150810.5CHRNA4, CHRNB4
21locomotory behaviorGO:00762610.4DRD2, CHRNB2, CHRNB4, CHRNA3, CHRNA4, ABAT
22regulation of dendrite morphogenesisGO:04881410.4CHRNA3, CHRNB2
23gamma-aminobutyric acid signaling pathwayGO:00721410.3GABRA2, GABRA6
24transportGO:00681010.3GABRD, GABRA6, CHRNA6, CHRNA5
25neurotransmitter transportGO:00683610.3GABRQ, GABRA2
26cognitionGO:05089010.3CHRNA4, CHRNB2
27signal transductionGO:00716510.1GABRQ, GABRD, GABRA6, CHRNB2, CHRNB4, CHRNA3
28associative learningGO:00830610.0CHRNB2, DRD2
29synaptic transmissionGO:0072689.8SLC32A1, GABRD, GABRA6, GABRA2, CHRNB2, CHRNB4

Molecular functions related to Nicotine Addiction according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1benzodiazepine receptor activityGO:00850310.3GABRA2, GABRA6
2ligand-gated ion channel activityGO:01527610.3CHRNB2, CHRNB4, CHRNA3, CHRNA4, CHRNA5
3acetylcholine receptor activityGO:01546410.2CHRNA5, CHRNA4, CHRNA6, CHRNA3, CHRNB4, CHRNB2
4acetylcholine-activated cation-selective channel activityGO:00488910.2CHRNB2, CHRNB4, CHRNA3, CHRNA6, CHRNA4, CHRNA5
5GABA-A receptor activityGO:00489010.2GABRQ, GABRD, GABRA6, GABRA2
6extracellular ligand-gated ion channel activityGO:00523010.1GABRA2, GABRA6, GABRD, GABRQ
7chloride channel activityGO:00525410.0GABRQ, GABRD, GABRA6, GABRA2
8acetylcholine bindingGO:04216610.0CHRNA4, CHRNA3, CHRNB2

Products for genes affiliated with Nicotine Addiction

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Sources for Nicotine Addiction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet