MCID: NCT012
MIFTS: 36

Nicotine Addiction malady

Summaries for Nicotine Addiction

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46OMIM, 32MalaCards
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MalaCards: Nicotine Addiction, also known as nicotine dependence, is related to lung cancer and nicotine dependence. An important gene associated with Nicotine Addiction is CHRNA4 (cholinergic receptor, nicotinic, alpha 4 (neuronal)), and among its related pathways are Nicotine Activity on Chromaffin Cells and SIDS Susceptibility Pathways. The compounds α-conotoxin mii and amobarbital have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and muscle.

Description from OMIM:46 188890

Aliases & Classifications for Nicotine Addiction

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46OMIM, 60UMLS
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Aliases & Descriptions:

nicotine addiction 46
nicotine dependence 60


Related Diseases for Nicotine Addiction

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17GeneCards, 18GeneDecks
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Diseases related to Nicotine Addiction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.6CHRNB4, CYP2A6, CHRNA3, CHRNA5
2nicotine dependence30.6CHRNA3, CHRNA4, CHRNA6, CYP2A6, CHRNB4, CHRNB2
3substance abuse30.6CNR1, DRD2
4cannabis dependence30.6GABRA2, CNR1
5drug dependence30.5CNR1, DRD2, CHRM2
6cocaine dependence30.5CHRNB4, DRD2, CHRNA3, CHRNA5
7schizophrenia30.5HCRT, DRD2, ABAT, CHRNA4, CHRM2, NTS
8substance dependence30.4CNR1, DRD2
9obesity30.3NTS, HCRT, CNR1, DRD2, CYP2A6
10panic disorder30.3ABAT
11major depressive disorder30.3CHRM2
12bipolar disorder30.2CNR1, DRD2
13mood disorder30.2HCRT, CNR1, DRD2
14alcohol dependence30.1GABRA2, GABRA6, DRD2, CNR1, CHRM2, CHRNB4
15parkinson's disease30.0HCRT, DRD2, CHRNA4, NTS, CNR1
16neuronitis10.4
17anxiety disorder10.3
18coronary artery disease10.2
19nicotine addiction, protection from10.2
20attention deficit hyperactivity disorder10.2
21pathological gambling10.1
22asthma10.1
23opiate dependence10.1
24pancreatic cancer10.1
25pancreatitis10.1
26nicotine dependence, protection against10.1
27alcohol abuse10.1
28peripheral vascular disease10.0
29bruxism10.0
30dependent personality disorder10.0
31conduct disorder10.0
32thromboangiitis obliterans10.0
33combat disorder10.0
34chromosomal disease10.0
35colon cancer10.0
36personality disorder10.0
37physical disorder10.0
38pneumonia10.0
39vascular disease10.0
40neuroblastoma10.0NTS
41dementia10.0HCRT
42schizoaffective disorder10.0DRD2
43anorexia nervosa10.0HCRT, CNR1
44lung cancer susceptibility 210.0CHRNA3, CHRNA5
45focal epilepsy10.0CHRNA4, CHRNB2
46autosomal dominant nocturnal frontal lobe epilepsy10.0CHRNA4, CHRNB2
47narcolepsy10.0HCRT, DRD2
48pulmonary disease, chronic obstructive10.0CHRNA3, CHRNA5
49restless legs syndrome10.0HCRT, DRD2
50eating disorder10.0HCRT, CNR1, NTS

Graphical network of the top 20 diseases related to Nicotine Addiction:



Diseases related to nicotine addiction

Clinical Features for Nicotine Addiction

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46OMIM
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Clinical features from OMIM:

188890

Drugs & Therapeutics for Nicotine Addiction

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nicotine Addiction

Drug clinical trials:

Search ClinicalTrials for Nicotine Addiction

Search NIH Clinical Center for Nicotine Addiction

Search CenterWatch for Nicotine Addiction

Genetic Tests for Nicotine Addiction

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Anatomical Context for Nicotine Addiction

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Animal Models for Nicotine Addiction or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nicotine Addiction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.0SLC32A1, CNR1, CHRNA3, CHRNB4, CHRNB2, DRD2
2MP:000536910.0DRD2, CHRNB2, CHRNB4, CHRNA3, CHRM2, HCRT
3MP:00107719.9DRD2, GABRA2, CHRNB2, CHRNB4, CHRNA4, CHRM2
4MP:00030129.7DRD2, GABRA2, CHRNA3, CHRNA4, NTS, CNR1
5MP:00053789.7DRD2, CHRNB2, CHRNB4, CHRNA3, CHRM2, GRIN3B
6MP:00053769.7DRD2, GABRA6, GABRA2, CHRNB2, CHRNB4, CHRNA3
7MP:00053869.5CHRNB4, CHRNB2, GABRA2, GABRA6, GABRD, DRD2
8MP:00036319.3SLC32A1, DRD2, GABRQ, GABRD, GABRA6, GABRA2

Publications for Nicotine Addiction

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Genetic Variations for Nicotine Addiction

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Expression for genes affiliated with Nicotine Addiction

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nicotine Addiction

Search GEO for disease gene expression data for Nicotine Addiction.

Pathways for genes affiliated with Nicotine Addiction

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore, 52R&D Systems, 59Tocris Bioscience, 51QIAGEN, 29KEGG
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Pathways related to Nicotine Addiction according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.3CHRNB4, CHRNA3
210.2CHRNB2, CHRM2, CHRNA4, CHRNB4
3
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10.1GABRA6, GABRA2, GABRQ, GABRD
4
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10.1GABRQ, GABRA2, GABRA6, GABRD
5
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10.1GABRD, GABRA2, GABRQ, GABRA6
610.1CHRNA6, CHRNA3, CHRNB4, CHRNB2, CHRNA4, CHRNA5
7
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10.1CHRNA5, CHRNB2, CHRNA4, CHRNA6, CHRNA3, CHRNB4
8
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10.1CHRNA5, CHRNA4, CHRNA6, CHRNA3, CHRNB2, CHRNB4
9
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10.0DRD2, CHRNB2, CHRNA3, CHRNA6, CHRNA4, CHRNA5
10
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9.7GABRA2, ABAT, CHRNA3, CHRNB4, CHRNB2, CHRNA6
119.7GABRQ, GABRD, GABRA6, GABRA2, CHRNB2, CHRNA4
12
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9.2CHRNB2, CHRNB4, CHRNA3, CHRNA6, CHRNA4, GRIN3B
13
Hide members
9.2CHRNA4, CHRM2, CHRNA5, GRIN3B, NTS, HCRT

Compounds for genes affiliated with Nicotine Addiction

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28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Nicotine Addiction according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1α-conotoxin mii2810.6CHRNA3, CHRNA6, CHRNA5
2amobarbital44 1111.6GABRA6, GABRA2, CHRNA4, CYP2A6
3varenicline44 1111.6CHRNA4, CHRNA6, CHRNA3
4hexobarbital44 1111.6GABRA6, GABRA2, CHRNA4, CYP2A6
5mecamylamine28 44 1112.6CHRNA4, CHRNA6, CHRNA3
6pentobarbital44 1111.6HCRT, CHRNA4, GABRA2, GABRA6
7Barbituric acid derivative1110.5GABRA2, GABRA6, CHRNA4
8amphetamine44 1111.5DRD2, NTS, HCRT, CNR1, CYP2A6
9(-)-bicuculline methochloride5910.5GABRA6, GABRD, GABRQ, GABRA2
10Butalbital1110.5CHRNA4, GABRA2, GABRA6
11(+)-bicuculline5910.5GABRA2, GABRA6, GABRD, GABRQ
12bupropion44 49 11 2413.5DRD2, CHRNA3, CNR1, CYP2A6
13(-)-bicuculline methiodide5910.5GABRQ, GABRA2, GABRA6, GABRD
14sr 95531 hydrobromide5910.5GABRA2, GABRA6, GABRD, GABRQ
15Heptabarbital1110.5CHRNA4, GABRA2, GABRA6
16galantamine44 49 1112.5CHRNB2, CHRNB4, CHRNA3, CHRNA6, CHRNA4, CHRNA5
17Clorazepate1110.5GABRA2, GABRA6, GABRD, GABRQ
18Metharbital1110.5CHRNA4, GABRA2, GABRA6
19bromazepam44 1111.5GABRQ, GABRD, GABRA6, GABRA2
20nitrazepam44 1111.5GABRQ, GABRD, GABRA6, GABRA2
21flurazepam44 1111.5GABRQ, GABRD, GABRA6, GABRA2, CYP2A6
22Temazepam1110.5GABRQ, GABRD, GABRA6, GABRA2
23alprazolam44 1111.5GABRQ, GABRD, GABRA6, GABRA2, CYP2A6
24Talbutal1110.5CHRNA4, GABRA2, GABRA6
25oxazepam49 1111.5GABRQ, GABRD, GABRA6, GABRA2
26diazepam44 49 28 1113.5ABAT, CYP2A6, GABRA2, GABRD, GABRQ
27midazolam44 49 1112.5GABRQ, GABRD, GABRA6, GABRA2, CYP2A6
28clobazam44 49 1112.5GABRQ, GABRD, GABRA6, GABRA2
29lorazepam44 49 1112.5DRD2, GABRQ, GABRD, GABRA6, GABRA2
30chlordiazepoxide44 1111.5GABRQ, GABRD, GABRA6, GABRA2
31Butethal1110.5GABRA6, CHRNA4, GABRA2
32tbps44 2811.5GABRQ, GABRD, GABRA6, GABRA2
33triazolam44 1111.5GABRQ, GABRD, GABRA6, GABRA2
34nmda44 2811.5GRIN3B, HCRT, CNR1, SLC32A1
35cocaine44 1111.4DRD2, CHRM2, NTS, HCRT, CNR1, ABAT
36Aprobarbital1110.4CHRNA4, GABRA2, GABRA6
37thip2810.4GABRA2, GABRA6, GABRD
38muscimol44 59 2812.4GABRQ, GABRD, GABRA6, GABRA2, HCRT, ABAT
395-hydroxytryptamine4410.4DRD2, CHRM2, NTS, HCRT, CNR1
40Barbital1110.4CHRNA4, GABRA2, GABRA6
41Butabarbital1110.4CHRNA4, GABRA2, GABRA6
42hexamethonium44 2811.3CHRNA3, CHRNA6, CHRNA4
43dopamine44 28 11 2413.3DRD2, CHRNA4, NTS, HCRT, CNR1, CYP2A6
44gaba4410.3DRD2, GABRA6, CHRM2, NTS, HCRT, CNR1
45acetylcholine44 49 28 11 2414.3DRD2, CHRNB2, CHRNA3, CHRNA4, CHRM2, NTS
46Methylphenobarbital1110.2CHRNA4, GABRA2, GABRA6
47opiate4410.2HCRT, NTS, CHRM2, DRD2
48Secobarbital1110.1CHRNA4, GABRA2, GABRA6
49nicotine44 49 28 1113.0ABAT, DRD2, CHRNB2, CHRNB4, CHRNA3, CHRNA6
50tetrodotoxin44 59 2811.9CHRM2, NTS, HCRT, CNR1

GO Terms for genes affiliated with Nicotine Addiction

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16Gene Ontology
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Cellular components related to Nicotine Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:03042510.2SLC32A1, CHRNA4, DRD2, CHRNA3
2acetylcholine-gated channel complexGO:00589210.1CHRNA3, CHRNA6, CHRNA5, CHRNA4, CHRNB2, CHRNB4
3chloride channel complexGO:03470710.0GABRQ, GABRD, GABRA2, GABRA6
4postsynaptic membraneGO:0452119.7GABRD, GABRQ, GABRA6, GABRA2, CHRNB2, CHRNB4
5integral to plasma membraneGO:0058879.6DRD2, GABRQ, GABRD, GABRA6, CHRNB4, CHRM2
6cell junctionGO:0300549.6GABRA2, CHRNB2, CHRNB4, CHRNA3, CHRNA6, CHRNA4
7plasma membraneGO:0058869.5CHRNB4, CHRNA6, GABRA6, DRD2, CHRNB2, CHRNA3

Biological processes related to Nicotine Addiction according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of action potentialGO:04575910.7CNR1, CHRNB2
2synaptic transmission involved in micturitionGO:06008410.6CHRNB2, CHRNA3, CHRNB4
3neurological system processGO:05087710.6CHRNA4, CHRNB2
4regulation of synaptic transmission, GABAergicGO:03222810.6DRD2, CNR1
5membrane depolarizationGO:05189910.6CHRNA6, CHRNA4, CHRNB2
6response to cocaineGO:04222010.6DRD2, CHRNB2, CNR1
7synaptic transmission, cholinergicGO:00727110.6CHRNB2, CHRNB4, CHRNA3, CHRNA4
8sensory perception of painGO:01923310.6CHRNB2, CNR1, CHRNA4
9negative regulation of blood pressureGO:04577610.6ABAT, DRD2, CNR1
10behavioral response to cocaineGO:04814810.6DRD2, ABAT
11regulation of dopamine secretionGO:01405910.5CHRNB2, DRD2, CHRNA6, CHRNA4
12regulation of smooth muscle contractionGO:00694010.5CHRNB4, CHRNA3
13behavioral response to nicotineGO:03509510.5CHRNA3, CHRNB2, CHRNB4, CHRNA5, CHRNA4
14response to iron ionGO:01003910.5DRD2, ABAT
15response to ethanolGO:04547110.5CHRNB2, ABAT, CNR1
16regulation of neurotransmitter secretionGO:04692810.5CHRNB4, HCRT
17response to nicotineGO:03509410.5ABAT, CNR1, DRD2, CHRNB2, CHRNA4
18response to hypoxiaGO:00166610.5CHRNB2, CHRNA4, ABAT, DRD2
19ion transportGO:00681110.5CHRNB4, CHRNA4, SLC32A1, CHRNB2, CHRNA3
20regulation of action potentialGO:00150810.5CHRNB4, CHRNA4
21locomotory behaviorGO:00762610.4ABAT, CHRNA4, CHRNB4, DRD2, CHRNA3, CHRNB2
22regulation of dendrite morphogenesisGO:04881410.4CHRNB2, CHRNA3
23gamma-aminobutyric acid signaling pathwayGO:00721410.3GABRA2, GABRA6
24transportGO:00681010.3GABRA6, CHRNA6, CHRNA5, GABRD
25neurotransmitter transportGO:00683610.3GABRA2, GABRQ
26cognitionGO:05089010.3CHRNB2, CHRNA4
27signal transductionGO:00716510.1CHRNB2, GABRA6, GABRD, CHRNA5, CHRNA4, GABRQ
28associative learningGO:00830610.0DRD2, CHRNB2
29synaptic transmissionGO:0072689.8GABRA2, CHRNB2, CHRNB4, CHRNA3, CHRNA6, SLC32A1

Molecular functions related to Nicotine Addiction according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1benzodiazepine receptor activityGO:00850310.3GABRA6, GABRA2
2ligand-gated ion channel activityGO:01527610.3CHRNA3, CHRNB4, CHRNA5, CHRNA4, CHRNB2
3acetylcholine receptor activityGO:01546410.2CHRNB4, CHRNB2, CHRNA3, CHRNA6, CHRNA4, CHRNA5
4acetylcholine-activated cation-selective channel activityGO:00488910.2CHRNA5, CHRNB2, CHRNB4, CHRNA3, CHRNA6, CHRNA4
5GABA-A receptor activityGO:00489010.2GABRQ, GABRD, GABRA6, GABRA2
6extracellular ligand-gated ion channel activityGO:00523010.1GABRQ, GABRA6, GABRA2, GABRD
7chloride channel activityGO:00525410.0GABRQ, GABRD, GABRA6, GABRA2
8acetylcholine bindingGO:04216610.0CHRNA4, CHRNA3, CHRNB2

Products for genes affiliated with Nicotine Addiction

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Sources for Nicotine Addiction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet