MCID: NCT002
MIFTS: 51

Nicotine Dependence malady

Summaries for Nicotine Dependence

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46OMIM, 32MalaCards
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MalaCards: Nicotine Dependence is related to alcohol dependence and schizophrenia. An important gene associated with Nicotine Dependence is GABBR2 (gamma-aminobutyric acid (GABA) B receptor, 2), and among its related pathways are Nicotine Activity on Chromaffin Cells and SIDS Susceptibility Pathways. The compounds [125i]epibatidine and [3h]cytisine have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and brain, and related mouse phenotypes are muscle and nervous system.

Description from OMIM:46 188890,612052

Aliases & Classifications for Nicotine Dependence

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8Disease Ontology, 46OMIM, 10DISEASES, 60UMLS
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Aliases & Descriptions:

nicotine dependence 8 46 10 60


External Ids:

Disease Ontology8 DOID:0050742
OMIM46 188890

Related Diseases for Nicotine Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Nicotine Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.1TAS2R16, ANKK1, CHRNA5, CHRNB4
2schizophrenia30.8DRD5, CHRNB2, CHRNA4, SLC6A3
3lung cancer30.6CHRNB4, CHRNA3, CHRNA5
4cocaine dependence30.6CHRNB4, CHRNA3, CHRNA5, SLC6A3
5drug dependence30.5SLC6A3
6substance dependence30.4SLC6A3, DRD5
7attention deficit hyperactivity disorder30.3SLC6A3, CHRNA4, DRD5
8bipolar disorder30.2DRD5, SLC6A3
9nicotine dependence, protection against30.2SLC6A3, GABBR2
10pathological gambling30.2SLC6A3
11parkinson's disease30.0SLC6A3, CHRNA4
12cannabis dependence10.4
13anxiety disorder10.3
14major depressive disorder10.2
15panic disorder10.2
16neuronitis10.1
17asthma10.1
18mood disorder10.1
19opiate dependence10.1
20pancreatic cancer10.1
21pancreatitis10.1
22peripheral vascular disease10.0
23bruxism10.0
24dependent personality disorder10.0
25conduct disorder10.0
26thromboangiitis obliterans10.0
27combat disorder10.0
28chromosomal disease10.0
29colon cancer10.0
30personality disorder10.0
31physical disorder10.0
32pneumonia10.0
33substance abuse10.0
34vascular disease10.0
35nicotine addiction10.0
36autosomal dominant nocturnal frontal lobe epilepsy10.0CHRNB2, CHRNA2, CHRNA4
37frontal lobe epilepsy10.0CHRNB2, CHRNA2, CHRNA4
38slow-channel congenital myasthenic syndrome10.0CHRND, CHRNB1, CHRNE
39cystic lymphangioma10.0CHRND, CHRNG
40congenital myasthenic syndrome10.0CHRND, CHRNB1, CHRNE
41lung cancer susceptibility 210.0CHRNA5, CHRNA3
42epilepsy syndrome10.0GABBR2, CHRNB2, CHRNA2, CHRNA4, SLC6A3
43multiple pterygium syndrome lethal type10.0CHRNG, CHRND
44myasthenic syndrome, fast-channel congenital10.0CHRND, CHRNE
45focal epilepsy10.0CHRNA4, CHRNB2
46myasthenia gravis10.0CHRNA4
47congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.0CHRNB1, CHRNE
48febrile seizures10.0CHRNA4, CHRNB2
49idiopathic generalized epilepsy10.0CHRNB2, CHRNA4
50lewy body dementia10.0SLC6A3

Graphical network of the top 20 diseases related to Nicotine Dependence:



Diseases related to nicotine dependence

Clinical Features for Nicotine Dependence

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46OMIM
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Clinical features from OMIM:

188890,612052

Drugs & Therapeutics for Nicotine Dependence

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nicotine Dependence

Drug clinical trials:

Search ClinicalTrials for Nicotine Dependence

Search NIH Clinical Center for Nicotine Dependence

Search CenterWatch for Nicotine Dependence

Genetic Tests for Nicotine Dependence

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Anatomical Context for Nicotine Dependence

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32MalaCards
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MalaCards organs/tissues related to Nicotine Dependence:

32
Testes, Lung, Brain, Pituitary, Cortex, Colon, Amygdala, Monocytes, Skeletal muscle, Heart, Ciliary ganglion

Animal Models for Nicotine Dependence or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nicotine Dependence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.4CHRNB4, CHRNG, CHRNA3, CHRNE, SLC6A3, CHRNB2
2MP:000363110.2CHRNA4, CHRNE, CHRNA5, CHRNA10, SLC6A3, CHRNA6
3MP:000538610.1SLC6A3, GABBR2, CHRNA5, CHRNE, CHRNB3, CHRNA4

Publications for Nicotine Dependence

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50PubMed
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Articles related to Nicotine Dependence:

(show top 50)    (show all 587)
idTitleAuthorsYear
1
The role of constraint in the development of nicotine, marijuana, and alcohol dependence in young adulthood. (24343204)
2014
2
Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans. (24401102)
2014
3
Increased pain in response to mechanical or thermal stimulation in a rat model of incision-induced pain with nicotine dependence and withdrawal. (23596472)
2013
4
Predictors of nicotine dependence symptoms among never-smoking adolescents: a longitudinal analysis from the Nicotine Dependence in Teens Study. (23195923)
2013
5
The "stop" and "go" of nicotine dependence: role of GABA and glutamate. (23732855)
2013
6
The first 7 days of a quit attempt predicts relapse: validation of a measure for screening medications for nicotine dependence. (23669629)
2013
7
The relationship between impulsivity, risk-taking propensity and nicotine dependence among older adolescent smokers. (23006247)
2013
8
A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia. (23308091)
2013
9
Associations between self-control and dimensions of nicotine dependence: a preliminary report. (23254232)
2013
10
Treating nicotine dependence by targeting attention-deficit/ hyperactivity disorder (ADHD) with OROS methylphenidate: the role of baseline ADHD severity and treatment response. (24229749)
2013
11
The FagerstrAPm Test for Nicotine Dependence as a predictor of smoking abstinence: a pooled analysis of varenicline clinical trial data. (22467778)
2012
12
Can urinary cotinine predict nicotine dependence level in smokers? (23317204)
2012
13
Heaviness of smoking index, number of cigarettes smoked and the Fagerstrom test for nicotine dependence among adult male Malaysians. (22502698)
2012
14
Transitions to regular smoking and nicotine dependence in the Adolescent National Comorbidity Survey (NCS-A). (22160800)
2012
15
Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. (22042774)
2012
16
Diurnal Evening Type is Associated with Current Smoking, Nicotine Dependence and Nicotine Intake in the Population Based National FINRISK 2007 Study. (22905332)
2012
17
Non-suicidal self-injury by intravenous application of nicotine in a patient with borderline personality disorder resulting in substance dependence. (21306599)
2011
18
Nicotine dependence and its risk factors among users of veterans health services, 2008-2009. (22005620)
2011
19
The relation between nicotine dependence and suicide attempts in the general population. (21443823)
2011
20
Anxiety, depression and methods of stress coping in patients with nicotine dependence syndrome. (21525809)
2011
21
DSM-IV nicotine dependence symptom characteristics for recent-onset smokers. (20061343)
2010
22
Patterns of adolescent smoking and later nicotine dependence in young adults: a 10-year prospective study. (20060987)
2010
23
Nicotine dependence subtypes among adolescent smokers: examining the occurrence, development and validity of distinct symptom profiles. (20307113)
2010
24
A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. (20158304)
2010
25
The Relationship Between Receptivity to Media Models of Smoking and Nicotine Dependence Among South African Adolescents. (20046795)
2009
26
The functional significance of craving in nicotine dependence. (19013944)
2009
27
Association between nicotine dependence and the -521 promoter polymorfism of the dopamine D4 receptor in patients with major depression]. (19827313)
2009
28
Dopamine genes and nicotine dependence in treatment-seeking and community smokers. (19494806)
2009
29
Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and FagerstrAPm Test for Nicotine Dependence. (19207358)
2009
30
Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans. (19290018)
2009
31
Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence. (19482438)
2009
32
Changes in cigarette use and nicotine dependence in the United States: evidence from the 2001-2002 wave of the national epidemiologic survey of alcoholism and related conditions. (19008515)
2009
33
Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population. (19307444)
2009
34
Nicotine dependence and psychiatric and substance use comorbidities in a sample of American Indian male veterans. (18845405)
2009
35
A comparison of the FagerstrAPm test for nicotine dependence and smoking prevalence across countries: updated data from Spain. (19149830)
2009
36
Craving-induced EEG reactivity in smokers: effects of mood induction, nicotine dependence and gender. (19212134)
2008
37
A placebo-controlled trial of modafinil for nicotine dependence. (18541389)
2008
38
An evaluation of the Italian version of the FagerstrAPm Test for Nicotine Dependence. (18763437)
2008
39
Posttraumatic stress disorder; combat exposure; and nicotine dependence, alcohol dependence, and major depression in male twins. (18396190)
2008
40
Race differences in nicotine dependence in the Collaborative Genetic study of Nicotine Dependence (COGEND). (18629733)
2008
41
An ontology-driven semantic mashup of gene and biological pathway information: application to the domain of nicotine dependence. (18395495)
2008
42
A twin study of smoking, nicotine dependence, and major depression in men. (18188750)
2008
43
Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. (18534558)
2008
44
Nicotine dependence, motivation to quit, and diagnosis among adult emergency department patients who smoke: a national survey. (18686174)
2008
45
Psychosocial predictors of nicotine dependence in Black and Puerto Rican adults: a longitudinal study. (18584459)
2008
46
MAOA methylation is associated with nicotine and alcohol dependence in women. (18454435)
2008
47
An integration of parents' and best friends' smoking, smoking-specific cognitions, and nicotine dependence in relation to readiness to quit smoking: a comparison between adolescents with and without asthma. (18287108)
2008
48
The neurobiological basis for partial agonist treatment of nicotine dependence. (16700843)
2006
49
Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated results. (15941945)
2005
50
CYP2E1*1D regulatory polymorphism: association with alcohol and nicotine dependence. (12777962)
2003

Genetic Variations for Nicotine Dependence

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Expression for genes affiliated with Nicotine Dependence

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nicotine Dependence

Search GEO for disease gene expression data for Nicotine Dependence.

Pathways for genes affiliated with Nicotine Dependence

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37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore
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Pathways related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CHRNB4, CHRNA3
210.4CHRNA4, CHRNB4, CHRNB2
310.4CHRNA4, CHRNA6, CHRNB2
4
Hide members
10.4CHRNB2, CHRNA3, CHRNA6, CHRNA4, CHRNA5
5
Hide members
10.4DRD5, GABBR2, CHRNB2, CHRNB4, CHRNA3, CHRNA6
6
Hide members
10.3CHRNG, CHRNA2, CHRND, CHRNA3, CHRNA6, CHRNA4
7
Hide members
10.3CHRNB2, CHRNB4, CHRNG, CHRNA2, CHRND, CHRNA3
8
Hide members
10.3GABBR2, CHRNB2, CHRNB4, CHRNG, CHRNA2, CHRND
910.3CHRNA4, CHRNB3, CHRNB1, CHRNE, CHRNA5, CHRNA10
10
Hide members
10.3CHRNA10, CHRNA5, CHRNB2, CHRNB4, CHRNG, CHRNA2
11
Hide members
10.2TAS2R16, GABBR2, CHRNB2, CHRNB4, CHRNG, CHRNA2

Compounds for genes affiliated with Nicotine Dependence

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28IUPHAR, 11DrugBank, 44Novoseek, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1[125i]epibatidine2810.8CHRNA3, CHRNA2, CHRNA4
2[3h]cytisine2810.8CHRNA2, CHRNA3, CHRNA4
3Pentolinium1110.8CHRNA10, CHRNA3, CHRNB4
4mecamylamine28 44 1112.8CHRNA2, CHRNA3, CHRNA6, CHRNA4
5[3h]epibatidine2810.8CHRNA2, CHRNA3, CHRNA4
6hexamethonium44 2811.8CHRNA4, CHRNA6, CHRNA3, CHRNA2
7α-conotoxin mii2810.8CHRNA3, CHRNA6, CHRNA5
8drugs used in nicotine dependence4910.8CHRNA3, CHRNA5, ANKK1
9rjr 2403 oxalate5910.8CHRNB2, CHRNA4
10sazetidine a dihydrochloride5910.8CHRNB2, CHRNA4
11varenicline44 1111.8CHRNA3, CHRNA6, CHRNA4
12varenicline tartrate5910.8CHRNB2, CHRNA4
13(-)-nicotine ditartrate5910.8CHRNB2, CHRNA4
14α-conotoxin pnia2810.8CHRNA3, CHRNA5
15desformylflustrabromine hydrochloride5910.8CHRNB2, CHRNA4
16α-conotoxin txia2810.8CHRNA3, CHRNA5
17α-conotoxin-gic2810.8CHRNA3, CHRNA5
18nicotine44 49 28 1113.7ANKK1, CHRNA10, CHRNA5, CHRNB3, CHRNA4, CHRNA6
19bupropion44 49 11 2413.7CHRNA3, ANKK1, SLC6A3
20ns1738 2810.7CHRNA3, CHRNA4
21a-867744 2810.7CHRNA3, CHRNA4
22galantamine44 49 1112.7CHRNA10, CHRNB2, CHRNB4, CHRNA5, CHRNE, CHRNB1
23acetylcholine44 49 28 11 2414.7SLC6A3, CHRNA4, CHRNA3, CHRND, CHRNB2
24ly2087101 2810.7CHRNA2, CHRNA4
25Chloroprocaine1110.6SLC6A3, CHRNA10
26olanzapine49 44 28 11 2414.6DRD5, ANKK1, SLC6A3
27Levomethadyl Acetate1110.6CHRNA3, CHRNB4
28procaine44 28 1112.6CHRNA2, SLC6A3
29clozapine44 28 49 1113.5SLC6A3, ANKK1, DRD5
30baclofen44 1111.5GABBR2, SLC6A3
31methadone44 49 1112.4ANKK1, CHRNA10
32methylphenidate44 49 1112.4DRD5, SLC6A3
33pramipexole44 49 28 1113.2SLC6A3, DRD5

GO Terms for genes affiliated with Nicotine Dependence

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16Gene Ontology
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Cellular components related to Nicotine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic membraneGO:04521110.4GABBR2, CHRNB2, CHRNB4, CHRNG, CHRNA2, CHRND
2cell junctionGO:03005410.3CHRNA2, CHRND, CHRNA3, CHRNA6, CHRNA4, CHRNB3
3integral to membraneGO:01602110.3TAS2R16, CHRNA10, CHRNB3, CHRNA4, CHRNA3, CHRNA2
4acetylcholine-gated channel complexGO:00589210.3CHRNB2, CHRNB4, CHRNG, CHRNA2, CHRND, CHRNA3
5plasma membraneGO:00588610.1CHRNA2, CHRNG, CHRNB4, CHRNB2, CHRND, CHRNA3
6integral to plasma membraneGO:00588710.1SLC6A3, DRD5, GABBR2, CHRNB4, CHRNB1, CHRNG

Biological processes related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1behavioral response to nicotineGO:03509510.8CHRNB2, CHRNA5, CHRNB1, CHRNA4, CHRNA3, CHRNB4
2synaptic transmission involved in micturitionGO:06008410.8CHRNA3, CHRNB4, CHRNB2
3locomotory behaviorGO:00762610.7CHRNB2, CHRNB4, CHRNA3, CHRNA4, SLC6A3
4neurological system processGO:05087710.7CHRNB1, CHRNA4, CHRNB2
5regulation of membrane potentialGO:04239110.7CHRNG, CHRND, CHRNA3, CHRNA4, CHRNB1, CHRNE
6synaptic transmission, cholinergicGO:00727110.7CHRNE, CHRNB1, CHRNB3, CHRNA4, CHRNA3, CHRNB4
7regulation of dopamine secretionGO:01405910.7CHRNB2, CHRNA6, CHRNA4
8ion transportGO:00681110.7CHRNA4, CHRNA3, CHRNA2, CHRNB4, CHRNB2
9transportGO:00681010.7CHRNG, CHRND, CHRNA6, CHRNB3, CHRNE, CHRNA5
10response to cocaineGO:04222010.7DRD5, CHRNB2, SLC6A3
11membrane depolarizationGO:05189910.7CHRNB2, CHRNA6, CHRNA4
12muscle contractionGO:00693610.7CHRNG, CHRND, CHRNB1, CHRNE
13response to nicotineGO:03509410.7SLC6A3, CHRNA4, CHRNB2
14regulation of dopamine metabolic processGO:04205310.7CHRNB2, SLC6A3
15signal transductionGO:00716510.6CHRND, CHRNA2, CHRNG, CHRNB4, CHRNB2, CHRNA3
16synaptic transmissionGO:00726810.6DRD5, SLC6A3, CHRNA5, CHRNE, CHRNB3, CHRNA4
17regulation of smooth muscle contractionGO:00694010.6CHRNA3, CHRNB4
18regulation of dendrite morphogenesisGO:04881410.6CHRNB2, CHRNA3
19regulation of action potentialGO:00150810.6CHRNB4, CHRNA4
20cognitionGO:05089010.5CHRNA4, CHRNB2
21associative learningGO:00830610.4CHRNB2, DRD5
22B cell activationGO:04211310.4CHRNA4, CHRNB2
23smooth muscle contractionGO:00693910.4CHRNB2, CHRNB4
24cation transportGO:00681210.1CHRNB1, CHRNE

Molecular functions related to Nicotine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.5SLC6A3, DRD5
2ligand-gated ion channel activityGO:01527610.4CHRNA5, CHRNB1, CHRNA4, CHRNA3, CHRNB4, CHRNB2
3acetylcholine receptor activityGO:01546410.4CHRNA2, CHRNG, CHRNB4, CHRNB2, CHRNA3, CHRNA6
4acetylcholine-activated cation-selective channel activityGO:00488910.4CHRNA10, CHRNA5, CHRNE, CHRNB1, CHRNB3, CHRNA4
5acetylcholine bindingGO:04216610.3CHRNB1, CHRNB3, CHRNA4, CHRNA3, CHRND, CHRNB2
6channel activityGO:01526710.1CHRNB1, CHRNB3, CHRNG

Products for genes affiliated with Nicotine Dependence

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Sources for Nicotine Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet