MCID: NCT002
MIFTS: 48

Nicotine Dependence malady

Mental diseases category

Summaries for Nicotine Dependence

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48OMIM, 34MalaCards
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MalaCards: Nicotine Dependence is related to lung cancer and alcohol dependence. An important gene associated with Nicotine Dependence is GABBR2 (gamma-aminobutyric acid (GABA) B receptor, 2), and among its related pathways are Nicotine Activity on Chromaffin Cells and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The compounds alpha-conotoxin txia and alpha-conotoxin-gic have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and brain, and related mouse phenotypes are behavior/neurological and nervous system.

Description from OMIM:48 188890,612052

Aliases & Classifications for Nicotine Dependence

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Sources:
9Disease Ontology, 48OMIM, 11DISEASES, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

nicotine dependence 9 48 11 63


External Ids:

Disease Ontology9 DOID:0050742
OMIM48 188890

Related Diseases for Nicotine Dependence

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Nicotine Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.7CHRNB4, CHRNA5, CHRNA3
2alcohol dependence30.6ANKK1, CHRNB4, TAS2R16, CHRNA5
3pathological gambling30.4SLC6A3
4nicotine dependence, protection against30.4SLC6A3, GABBR2
5attention deficit hyperactivity disorder30.4DRD5, SLC6A3
6substance dependence30.4DRD5, SLC6A3
7substance abuse30.2SLC6A3
8conduct disorder30.1DRD5, SLC6A3
9cocaine dependence30.1CHRNA3, CHRNB4, CHRNA5, SLC6A3
10schizophrenia10.6
11anxiety disorder10.3
12blindness10.3
13major depressive disorder10.2
14neuronitis10.2
15asthma10.2
16pancreatic cancer10.2
17pancreatitis10.2
18lung cancer susceptibility 210.1CHRNA3, CHRNA5
19autosomal dominant nocturnal frontal lobe epilepsy10.1CHRNB2, CHRNA2
20frontal lobe epilepsy10.1CHRNA2, CHRNB2
21pulmonary disease, chronic obstructive10.1CHRNA5, CHRNA3
22slow-channel congenital myasthenic syndrome10.0CHRNB1, CHRND
23congenital myasthenic syndrome10.0CHRNB1, CHRND
24antisocial personality disorder10.0ANKK1, SLC6A3
25gilles de la tourette syndrome10.0DRD5, SLC6A3
26peripheral vascular disease10.0
27cannabis dependence10.0
28bruxism10.0
29peripheral artery disease10.0
30thromboangiitis obliterans10.0
31panic disorder10.0
32parkinson's disease10.0
33artery disease10.0
34bipolar disorder10.0
35colon cancer10.0
36mood disorder10.0
37personality disorder10.0
38pneumonia10.0
39vascular disease10.0
40chronic pain10.0
41insomnia10.0
42nicotine addiction10.0
43migraine10.0DRD5, SLC6A3
44epilepsy syndrome10.0CHRNB2, CHRNA2, GABBR2, SLC6A3

Graphical network of the top 20 diseases related to Nicotine Dependence:



Diseases related to nicotine dependence

Symptoms for Nicotine Dependence

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Sources:
48OMIM
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Clinical features from OMIM:

188890,612052

Drugs & Therapeutics for Nicotine Dependence

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Nicotine Dependence

Drug clinical trials:

Search ClinicalTrials for Nicotine Dependence

Search NIH Clinical Center for Nicotine Dependence

Search CenterWatch for Nicotine Dependence

Genetic Tests for Nicotine Dependence

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Anatomical Context for Nicotine Dependence

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Sources:
34MalaCards
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MalaCards organs/tissues related to Nicotine Dependence:

34
Testes, Lung, Brain, Heart, Colon, Amygdala

Animal Models for Nicotine Dependence or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Nicotine Dependence:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.3CHRNB3, CHRNA5, CHRNB4, CHRNB2, CHRNA3, GABBR2
2MP:00036317.2CHRNB1, CHRNA2, CHRNA5, CHRNB4, CHRNB2, CHRNA3

Publications for Nicotine Dependence

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Sources:
53PubMed
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Articles related to Nicotine Dependence:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Increased pain in response to mechanical or thermal stimulation in a rat model of incision-induced pain with nicotine dependence and withdrawal. (23596472)
2013
2
Predictors of nicotine dependence symptoms among never-smoking adolescents: a longitudinal analysis from the Nicotine Dependence in Teens Study. (23195923)
2013
3
An integrated data analysis approach to investigating measurement equivalence of DSM nicotine dependence symptoms. (23021772)
2013
4
The "stop" and "go" of nicotine dependence: role of GABA and glutamate. (23732855)
2013
5
Effects of asthma on nicotine dependence development and smoking cessation attempts in adolescence. (23347267)
2013
6
Nicotine dependence and cost-effectiveness of individualized support for smoking cessation: evidence from practice at a worksite in Japan. (23383289)
2013
7
The first 7 days of a quit attempt predicts relapse: validation of a measure for screening medications for nicotine dependence. (23669629)
2013
8
Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. (22006218)
2012
9
Does current versus former smoking play a role in the relationship between anxiety and mood disorders and nicotine dependence? (22342203)
2012
10
Risk factors associated with nicotine dependence in a sample of Romanian pregnant smokers. (22537737)
2012
11
Trajectories of criteria of nicotine dependence from adolescence to early adulthood. (22513378)
2012
12
ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. (22377092)
2012
13
Assessment of nicotine dependence among smokers in a selected rural population in Kerala, India. (22938438)
2012
14
Impaired sleep quality and sleep duration in smokers-results from the German Multicenter Study on Nicotine Dependence. (22913370)
2012
15
Association study of 45 candidate genes in nicotine dependence in Han Chinese. (22309839)
2012
16
A role for the DRD4 exon III VNTR in modifying the association between nicotine dependence and neuroticism. (21127031)
2011
17
Nicotine dependence, abuse and craving: dimensionality in an Israeli sample. (21545668)
2011
18
Treatment of nicotine dependence with Chantix (varenicline). (21834368)
2011
19
Cocaine and amphetamine regulated transcript (CART) gene in the comorbidity of schizophrenia with alcohol use disorders and nicotine dependence. (20362026)
2010
20
An audit of the prevalence of recorded nicotine dependence treatment in an Australian psychiatric hospital. (20618273)
2010
21
The FagerstrAPm test for nicotine dependence in an Indian sample of daily smokers with poly drug use. (20837653)
2010
22
Dimensionality of DSM-IV nicotine dependence in a national sample: an item response theory application. (20045597)
2010
23
Early course of nicotine dependence in adolescent smokers. (20439592)
2010
24
Does smoking cue-induced craving tell us anything important about nicotine dependence? (19426293)
2009
25
Differential item functioning of the English and Chinese versions of the Fagerstrom Test for Nicotine Dependence. (18929444)
2009
26
Nicotine dependence and genetic variation in the nicotinic receptors. (19596527)
2009
27
A testable prognostic model of nicotine dependence. (19184766)
2009
28
Sequencing of DSM-IV criteria of nicotine dependence. (19489755)
2009
29
A comparison of the FagerstrAPm Test for Nicotine Dependence and smoking prevalence across countries. (18412764)
2008
30
Delay discounting and smoking: association with the FagerstrAPm Test for Nicotine Dependence but not cigarettes smoked per day. (18946776)
2008
31
Linkage of nicotine dependence and smoking behavior on 10q, 7q and 11p in twins with homogeneous genetic background. (17549066)
2008
32
Comorbidity of psychiatric disorders and nicotine dependence among adolescents: findings from a prospective, longitudinal study. (18827718)
2008
33
Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers. (18777128)
2008
34
Craving-induced EEG reactivity in smokers: effects of mood induction, nicotine dependence and gender. (19212134)
2008
35
Relationship between PTSD symptomatology and nicotine dependence severity in crime victims. (18442884)
2008
36
Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. (18482426)
2008
37
Individual differences in nicotine dependence, withdrawal symptoms, and sex predict transient fMRI-BOLD responses to smoking cues. (17987060)
2008
38
Nicotine dependence mediates the relations between insomnia and both panic and posttraumatic stress disorder in the NCS-R sample. (17935215)
2008
39
Association of low striatal dopamine d2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse. (18316420)
2008
40
Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. (17171661)
2007
41
On the development of nicotine dependence in adolescence. (17553635)
2007
42
Predictive validity of four nicotine dependence measures in a college sample. (16930859)
2007
43
Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. (16874522)
2006
44
Aripiprazole therapy for nicotine dependence. (16862255)
2006
45
Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. (16395295)
2006
46
Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated results. (15941945)
2005
47
Elucidating the role of genetic factors in smoking behavior and nicotine dependence. (12627466)
2003
48
An association study of DRD5 with smoking initiation and progression to nicotine dependence. (11353446)
2001
49
Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence. (11449402)
2001
50
Inpatient treatment of severe nicotine dependence in a patient with thromboangiitis obliterans (Buerger's disease). (9621859)
1998

Variations for Nicotine Dependence

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Expression for genes affiliated with Nicotine Dependence

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nicotine Dependence

Search GEO for disease gene expression data for Nicotine Dependence.

Pathways for genes affiliated with Nicotine Dependence

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Sources:
51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 31KEGG, 54QIAGEN, 56Reactome, 13EMD Millipore
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Pathways related to Nicotine Dependence according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9CHRNB4, CHRNA3
2
Show member pathways
Nicotine Activity on Dopaminergic Neurons39
9.5CHRNA5, CHRNA3, CHRNB2
3
Show member pathways
9.1CHRNA2, CHRNA3, CHRND, CHRNA5
4
Show member pathways
9.0TAS2R38, TAS2R16, GABBR2
5
Show member pathways
8.4GABBR2, DRD5, CHRNA3, CHRNB2, CHRNB4, SLC6A3
6
Show member pathways
8.0CHRNB3, CHRNA5, CHRNB4, CHRNB2, CHRND, CHRNA3
77.7CHRNB3, CHRNA5, CHRNB4, CHRNB2, CHRND, CHRNA3
8
Show member pathways
7.7CHRND, CHRNA3, CHRNB4, CHRNB1, CHRNA2, CHRNA5
9
Show member pathways
7.5CHRNA2, CHRNB3, CHRNA5, GABBR2, CHRNA3, SLC6A3
10
Show member pathways
5.6CHRNB3, CHRNB1, CHRND, TAS2R38, CHRNA5, CHRNB4

Compounds for genes affiliated with Nicotine Dependence

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Sources:
30IUPHAR, 46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1alpha-conotoxin txia3010.3CHRNA5, CHRNA3
2alpha-conotoxin-gic3010.2CHRNA3, CHRNA5
3alpha-conotoxin pnia3010.2CHRNA3, CHRNA5
4alpha-conotoxin mii3010.2CHRNA5, CHRNA3
5[3h]cytisine3010.2CHRNA2, CHRNA3
6[125i]epibatidine3010.2CHRNA2, CHRNA3
7[3h]epibatidine3010.2CHRNA2, CHRNA3
8procaine46 30 1212.1SLC6A3, CHRNA2
9baclofen46 1211.1SLC6A3, GABBR2
10mecamylamine46 30 1212.1CHRNA3, CHRNA2
11hexamethonium46 3011.1CHRNA2, CHRNA3
12methylphenidate46 52 1211.9SLC6A3, DRD5
13pramipexole46 30 52 1212.8SLC6A3, DRD5
14apomorphine30 46 1211.7SLC6A3, DRD5
15drugs used in nicotine dependence529.6CHRNA5, ANKK1, CHRNA3
16bupropion52 46 25 1212.6CHRNA3, ANKK1, SLC6A3
17risperidone46 52 30 62 25 1214.6ANKK1, SLC6A3
18quetiapine46 52 30 25 1213.6DRD5, SLC6A3
19sinigrin39.5TAS2R16, TAS2R38
20chlorpheniramine46 3 25 1212.5TAS2R38, SLC6A3
21bromocriptine46 30 1211.4SLC6A3, DRD5
22olanzapine46 52 30 25 1213.4ANKK1, DRD5, SLC6A3
23diphenidol3 1210.3TAS2R38, TAS2R16
24clozapine46 30 52 1212.3ANKK1, SLC6A3, DRD5
25acetylcholine46 52 30 25 1213.2SLC6A3, CHRNA3, CHRNB2, CHRND
26galantamine46 52 1210.0CHRND, CHRNB2, CHRNB4, CHRNA5, CHRNB3, CHRNA3
27nicotine46 30 52 1211.0CHRNA5, CHRNB3, CHRNA2, ANKK1, SLC6A3, CHRNB2

GO Terms for genes affiliated with Nicotine Dependence

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Sources:
17Gene Ontology
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Cellular components related to Nicotine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.8CHRNB1, CHRNB4, DRD5, GABBR2, SLC6A3
2acetylcholine-gated channel complexGO:0058927.8CHRNA3, CHRND, CHRNB2, CHRNB4, CHRNA5, CHRNB3
3postsynaptic membraneGO:0452117.5CHRNB1, GABBR2, CHRNA3, CHRND, CHRNB2, CHRNB4
4cell junctionGO:0300547.4CHRNA5, CHRNA3, CHRND, CHRNB2, CHRNB4, CHRNB3
5integral component of membraneGO:0160216.9SLC6A3, TAS2R38, TAS2R16, CHRNA3, CHRNB2, CHRNB4
6plasma membraneGO:0058865.6SLC6A3, CHRNB3, CHRNA5, CHRNB4, CHRNB2, CHRND

Biological processes related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:04205310.0SLC6A3, CHRNB2
2regulation of smooth muscle contractionGO:00694010.0CHRNA3, CHRNB4
3neurological system processGO:0508779.9CHRNB2, CHRNB1
4regulation of dendrite morphogenesisGO:0488149.8CHRNB2, CHRNA3
5response to nicotineGO:0350949.8SLC6A3, CHRNB2
6action potentialGO:0015089.8CHRNB2, CHRNB4
7synaptic transmission involved in micturitionGO:0600849.8CHRNB4, CHRNB2, CHRNA3
8smooth muscle contractionGO:0069399.7CHRNB2, CHRNB4
9protein heterooligomerizationGO:0512919.6CHRNB2, CHRNB3, CHRNA2
10response to cocaineGO:0422209.5SLC6A3, DRD5, CHRNB2
11regulation of membrane potentialGO:0423919.5CHRNB1, CHRND, CHRNA3
12locomotory behaviorGO:0076269.5CHRNB4, CHRNB2, CHRNA3, SLC6A3
13ion transportGO:0068119.4CHRNA2, CHRNB4, CHRNB2, CHRNA3
14transportGO:0068109.3CHRNB3, CHRNA5, CHRND, SLC6A3
15associative learningGO:0083069.2DRD5, CHRNB2
16behavioral response to nicotineGO:0350959.2CHRNB1, CHRNA5, CHRNB4, CHRNB2, CHRNA3
17ion transmembrane transportGO:0342209.1CHRNB1, CHRNA5, CHRNB4, CHRNB2, CHRNA3
18synaptic transmission, cholinergicGO:0072719.0CHRNA3, CHRNB2, CHRNB4, CHRNB3, CHRNB1
19cation transportGO:0068128.4CHRNB1, CHRNA2, CHRNB3, CHRNA5, CHRNB4, CHRND
20signal transductionGO:0071658.0CHRNB1, CHRNA2, CHRNB3, CHRNA5, CHRNB4, CHRNB2
21synaptic transmissionGO:0072687.3SLC6A3, CHRNA2, CHRNB3, GABBR2, DRD5, CHRNA3

Molecular functions related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1channel activityGO:0152679.8CHRNB3, CHRNB1
2dopamine bindingGO:0352409.4DRD5, SLC6A3
3drug bindingGO:0081449.0CHRNB2, CHRNA2, CHRNB3, SLC6A3
4ligand-gated ion channel activityGO:0152768.8CHRNB4, CHRNB1, CHRNA3, CHRNB2, CHRNA5
5acetylcholine receptor activityGO:0154648.7CHRNA3, CHRNB2, CHRNB4, CHRNA5, CHRNA2, CHRNB1
6acetylcholine bindingGO:0421668.3CHRNA3, CHRND, CHRNB2, CHRNB3, CHRNA2, CHRNB1
7acetylcholine-activated cation-selective channel activityGO:0048897.8CHRNA3, CHRNB1, CHRND, CHRNB2, CHRNB4, CHRNA5

Products for genes affiliated with Nicotine Dependence

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Sources for Nicotine Dependence

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet