MCID: NCT002
MIFTS: 49

Nicotine Dependence malady

Mental diseases category
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Summaries for Nicotine Dependence

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MalaCards based summary: Nicotine Dependence is related to pathological gambling and nicotine dependence, protection against. An important gene associated with Nicotine Dependence is GABBR2 (gamma-aminobutyric acid (GABA) B receptor, 2), and among its related pathways are Nicotine Activity on Chromaffin Cells and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The compounds alpha-conotoxin txia and alpha-conotoxin pnia have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and brain, and related mouse phenotypes are behavior/neurological and nervous system.

Descriptions from OMIM:46 188890,612052

Aliases & Classifications for Nicotine Dependence

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Nicotine Dependence, Aliases & Descriptions:

Name: Nicotine Dependence 8 46 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:0050742
OMIM46 188890

Related Diseases for Nicotine Dependence

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Diseases related to Nicotine Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1pathological gambling31.0SLC6A3
2nicotine dependence, protection against30.9SLC6A3, GABBR2
3lung cancer30.7CHRNB4, CHRNA5, CHRNA3
4substance abuse30.7SLC6A3
5substance dependence30.7DRD5, SLC6A3
6attention deficit hyperactivity disorder30.6SLC6A3, DRD5
7alcohol dependence30.6ANKK1, CHRNB4, TAS2R16, CHRNA5
8conduct disorder30.4DRD5, SLC6A3
9cocaine dependence30.3CHRNA3, CHRNB4, CHRNA5, SLC6A3
10schizophrenia10.6
11lung cancer susceptibility 210.4CHRNA3, CHRNA5
12anxiety disorder10.3
13autosomal dominant nocturnal frontal lobe epilepsy10.3CHRNB2, CHRNA2
14frontal lobe epilepsy10.3CHRNA2, CHRNB2
15chronic obstructive pulmonary disease10.3CHRNA3, CHRNA5
16major depressive disorder10.3
17blindness10.3
18slow-channel congenital myasthenic syndrome10.2CHRNB1, CHRND
19congenital myasthenic syndrome10.2CHRNB1, CHRND
20asthma10.2
21neuronitis10.2
22antisocial personality disorder10.2ANKK1, SLC6A3
23gilles de la tourette syndrome10.1SLC6A3, DRD5
24epilepsy syndrome10.1CHRNB2, CHRNA2, GABBR2, SLC6A3
25peripheral vascular disease10.0
26bipolar disorder10.0
27lung adenocarcinoma10.0
28pancreatic cancer10.0
29parkinson's disease10.0
30thromboangiitis obliterans10.0
31bruxism10.0
32cannabis dependence10.0
33panic disorder10.0
34peripheral artery disease10.0
35adenocarcinoma10.0
36artery disease10.0
37colon cancer10.0
38mood disorder10.0
39pancreatitis10.0
40personality disorder10.0
41pneumonia10.0
42vascular disease10.0
43chronic pain10.0

Graphical network of the top 20 diseases related to Nicotine Dependence:



Diseases related to nicotine dependence

Symptoms for Nicotine Dependence

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Clinical features from OMIM:

188890,612052

Drugs & Therapeutics for Nicotine Dependence

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Drug clinical trials:

Search ClinicalTrials for Nicotine Dependence

Search NIH Clinical Center for Nicotine Dependence

Genetic Tests for Nicotine Dependence

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Anatomical Context for Nicotine Dependence

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MalaCards organs/tissues related to Nicotine Dependence:

32
Testes, Lung, Brain, Cortex, Heart, Colon, Amygdala, Cingulate cortex

Animal Models for Nicotine Dependence or affiliated genes

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MGI Mouse Phenotypes related to Nicotine Dependence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.7CHRNB3, CHRNA5, CHRNB4, CHRNB2, CHRNA3, GABBR2
2MP:00036317.6CHRNB1, CHRNA2, CHRNA5, CHRNB4, CHRNB2, CHRNA3

Publications for Nicotine Dependence

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Articles related to Nicotine Dependence:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Depression and anxiety symptoms moderate the relation between negative reinforcement smoking outcome expectancies and nicotine dependence. (25208195)
2014
2
NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. (25273375)
2014
3
Increased pain in response to mechanical or thermal stimulation in a rat model of incision-induced pain with nicotine dependence and withdrawal. (23596472)
2013
4
Predictors of nicotine dependence symptoms among never-smoking adolescents: a longitudinal analysis from the Nicotine Dependence in Teens Study. (23195923)
2013
5
An integrated data analysis approach to investigating measurement equivalence of DSM nicotine dependence symptoms. (23021772)
2013
6
The "stop" and "go" of nicotine dependence: role of GABA and glutamate. (23732855)
2013
7
Effects of asthma on nicotine dependence development and smoking cessation attempts in adolescence. (23347267)
2013
8
Nicotine dependence and cost-effectiveness of individualized support for smoking cessation: evidence from practice at a worksite in Japan. (23383289)
2013
9
The first 7 days of a quit attempt predicts relapse: validation of a measure for screening medications for nicotine dependence. (23669629)
2013
10
Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. (22006218)
2012
11
Does current versus former smoking play a role in the relationship between anxiety and mood disorders and nicotine dependence? (22342203)
2012
12
Risk factors associated with nicotine dependence in a sample of Romanian pregnant smokers. (22537737)
2012
13
Trajectories of criteria of nicotine dependence from adolescence to early adulthood. (22513378)
2012
14
ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. (22377092)
2012
15
Assessment of nicotine dependence among smokers in a selected rural population in Kerala, India. (22938438)
2012
16
Impaired sleep quality and sleep duration in smokers-results from the German Multicenter Study on Nicotine Dependence. (22913370)
2012
17
A role for the DRD4 exon III VNTR in modifying the association between nicotine dependence and neuroticism. (21127031)
2011
18
Nicotine dependence, abuse and craving: dimensionality in an Israeli sample. (21545668)
2011
19
Treatment of nicotine dependence with Chantix (varenicline). (21834368)
2011
20
Cocaine and amphetamine regulated transcript (CART) gene in the comorbidity of schizophrenia with alcohol use disorders and nicotine dependence. (20362026)
2010
21
An audit of the prevalence of recorded nicotine dependence treatment in an Australian psychiatric hospital. (20618273)
2010
22
The FagerstrAPm test for nicotine dependence in an Indian sample of daily smokers with poly drug use. (20837653)
2010
23
Dimensionality of DSM-IV nicotine dependence in a national sample: an item response theory application. (20045597)
2010
24
Early course of nicotine dependence in adolescent smokers. (20439592)
2010
25
Does smoking cue-induced craving tell us anything important about nicotine dependence? (19426293)
2009
26
Differential item functioning of the English and Chinese versions of the Fagerstrom Test for Nicotine Dependence. (18929444)
2009
27
Nicotine dependence and genetic variation in the nicotinic receptors. (19596527)
2009
28
A testable prognostic model of nicotine dependence. (19184766)
2009
29
Sequencing of DSM-IV criteria of nicotine dependence. (19489755)
2009
30
A comparison of the FagerstrAPm Test for Nicotine Dependence and smoking prevalence across countries. (18412764)
2008
31
Linkage of nicotine dependence and smoking behavior on 10q, 7q and 11p in twins with homogeneous genetic background. (17549066)
2008
32
Comorbidity of psychiatric disorders and nicotine dependence among adolescents: findings from a prospective, longitudinal study. (18827718)
2008
33
Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers. (18777128)
2008
34
Craving-induced EEG reactivity in smokers: effects of mood induction, nicotine dependence and gender. (19212134)
2008
35
Relationship between PTSD symptomatology and nicotine dependence severity in crime victims. (18442884)
2008
36
Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. (18482426)
2008
37
Individual differences in nicotine dependence, withdrawal symptoms, and sex predict transient fMRI-BOLD responses to smoking cues. (17987060)
2008
38
Nicotine dependence mediates the relations between insomnia and both panic and posttraumatic stress disorder in the NCS-R sample. (17935215)
2008
39
Association of low striatal dopamine d2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse. (18316420)
2008
40
Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. (17171661)
2007
41
On the development of nicotine dependence in adolescence. (17553635)
2007
42
Predictive validity of four nicotine dependence measures in a college sample. (16930859)
2007
43
Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. (16874522)
2006
44
Aripiprazole therapy for nicotine dependence. (16862255)
2006
45
Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. (16395295)
2006
46
Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated results. (15941945)
2005
47
Elucidating the role of genetic factors in smoking behavior and nicotine dependence. (12627466)
2003
48
An association study of DRD5 with smoking initiation and progression to nicotine dependence. (11353446)
2001
49
Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence. (11449402)
2001
50
Inpatient treatment of severe nicotine dependence in a patient with thromboangiitis obliterans (Buerger's disease). (9621859)
1998

Variations for Nicotine Dependence

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Clinvar genetic disease variations for Nicotine Dependence:

6
id Gene Name Type Significance SNP ID Assembly Location
1CHRNA5NM_000745.3(CHRNA5): c.1192G> A (p.Asp398Asn)single nucleotide variantrisk factorrs16969968GRCh37Chr 15, 78882925: 78882925
2CHRNA3NM_001166694.1(CHRNA3): c.645C> T (p.Tyr215=)single nucleotide variantrisk factorrs1051730GRCh37Chr 15, 78894339: 78894339
3GABBR2NM_005458.7(GABBR2): c.360A> G (p.Ala120=)single nucleotide variantrisk factorrs3750344GRCh37Chr 9, 101340316: 101340316
4GABBR2GABABR2, HAPLOTYPE, TATA (rs1435252, rs3780422, rs2779562, rs3750344)undetermined variantrisk factor

Expression for genes affiliated with Nicotine Dependence

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Expression patterns in normal tissues for genes affiliated with Nicotine Dependence

Search GEO for disease gene expression data for Nicotine Dependence.

Pathways for genes affiliated with Nicotine Dependence

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Pathways related to Nicotine Dependence according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0CHRNB4, CHRNA3
2
Show member pathways
Nicotine Activity on Dopaminergic Neurons37
9.7CHRNA5, CHRNA3, CHRNB2
3
Show member pathways
9.5TAS2R38, TAS2R16, GABBR2
4
Show member pathways
9.4CHRNA2, CHRNA3, CHRND, CHRNA5
5
Show member pathways
8.7GABBR2, DRD5, CHRNA3, CHRNB2, CHRNB4, SLC6A3
6
Show member pathways
8.5CHRND, CHRNA2, CHRNB3, CHRNA5, CHRNB4, CHRNB2
7
Show member pathways
8.2CHRND, CHRNA3, CHRNB4, CHRNA5, CHRNB3, CHRNA2
88.2CHRND, CHRNB1, CHRNB3, CHRNA5, CHRNA3, CHRNB4
9
Show member pathways
8.1GABBR2, CHRND, SLC6A3, CHRNA3, CHRNB2, CHRNB4
10
Show member pathways
6.7DRD5, GABBR2, TAS2R16, TAS2R38, CHRNB1, CHRND

Compounds for genes affiliated with Nicotine Dependence

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Compounds related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1alpha-conotoxin txia2810.4CHRNA3, CHRNA5
2alpha-conotoxin pnia2810.4CHRNA3, CHRNA5
3alpha-conotoxin-gic2810.4CHRNA5, CHRNA3
4alpha-conotoxin mii2810.3CHRNA5, CHRNA3
5[125i]epibatidine2810.3CHRNA2, CHRNA3
6[3h]cytisine2810.3CHRNA2, CHRNA3
7[3h]epibatidine2810.3CHRNA2, CHRNA3
8mecamylamine44 28 1112.3CHRNA3, CHRNA2
9hexamethonium44 2811.2CHRNA2, CHRNA3
10procaine44 28 1112.2SLC6A3, CHRNA2
11baclofen44 1111.2SLC6A3, GABBR2
12sinigrin210.0TAS2R16, TAS2R38
13drugs used in nicotine dependence5010.0CHRNA5, CHRNA3, ANKK1
14bupropion50 44 24 1112.9CHRNA3, SLC6A3, ANKK1
15methylphenidate44 50 1111.9SLC6A3, DRD5
16chlorpheniramine44 2 24 1112.8TAS2R38, SLC6A3
17pramipexole44 28 50 1112.8SLC6A3, DRD5
18risperidone44 50 28 61 24 1114.8ANKK1, SLC6A3
19diphenidol2 1110.8TAS2R38, TAS2R16
20apomorphine28 44 1111.7SLC6A3, DRD5
21quetiapine44 50 28 24 1113.6DRD5, SLC6A3
22olanzapine44 50 28 24 1113.6ANKK1, DRD5, SLC6A3
23acetylcholine44 50 28 24 1113.6SLC6A3, CHRNA3, CHRNB2, CHRND
24clozapine44 28 50 1112.6ANKK1, SLC6A3, DRD5
25bromocriptine44 28 1111.4SLC6A3, DRD5
26nicotine44 28 50 1111.6CHRNA5, ANKK1, CHRNA3, CHRNB4, SLC6A3, CHRNA2
27galantamine44 50 1110.6CHRND, CHRNB2, CHRNB4, CHRNA5, CHRNB3, CHRNA3

GO Terms for genes affiliated with Nicotine Dependence

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Cellular components related to Nicotine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058879.0GABBR2, CHRNB1, CHRNB4, DRD5, SLC6A3
2acetylcholine-gated channel complexGO:0058928.3CHRNA3, CHRND, CHRNB2, CHRNB4, CHRNA5, CHRNB3
3postsynaptic membraneGO:0452118.1CHRNB1, GABBR2, CHRNA3, CHRND, CHRNB2, CHRNB4
4cell junctionGO:0300548.0CHRNA5, CHRNA3, CHRND, CHRNB2, CHRNB4, CHRNB3
5integral component of membraneGO:0160216.9TAS2R38, TAS2R16, CHRNB3, C7orf66, CHRNA3, CHRNB2
6plasma membraneGO:0058866.6CHRND, SLC6A3, CHRNB3, CHRNA5, CHRNB4, CHRNB2

Biological processes related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:04205310.1SLC6A3, CHRNB2
2regulation of smooth muscle contractionGO:00694010.1CHRNA3, CHRNB4
3neurological system processGO:05087710.0CHRNB2, CHRNB1
4regulation of dendrite morphogenesisGO:04881410.0CHRNB2, CHRNA3
5synaptic transmission involved in micturitionGO:06008410.0CHRNB4, CHRNB2, CHRNA3
6response to nicotineGO:0350949.9SLC6A3, CHRNB2
7action potentialGO:0015089.9CHRNB2, CHRNB4
8protein heterooligomerizationGO:0512919.8CHRNB2, CHRNB3, CHRNA2
9regulation of membrane potentialGO:0423919.8CHRNB1, CHRND, CHRNA3
10smooth muscle contractionGO:0069399.8CHRNB2, CHRNB4
11locomotory behaviorGO:0076269.7CHRNB4, CHRNB2, CHRNA3, SLC6A3
12response to cocaineGO:0422209.7SLC6A3, DRD5, CHRNB2
13ion transportGO:0068119.7CHRNA2, CHRNB4, CHRNB2, CHRNA3
14transportGO:0068109.5CHRNB3, CHRNA5, CHRND, SLC6A3
15behavioral response to nicotineGO:0350959.5CHRNB1, CHRNA5, CHRNB4, CHRNB2, CHRNA3
16ion transmembrane transportGO:0342209.4CHRNB1, CHRNA5, CHRNB4, CHRNB2, CHRNA3
17synaptic transmission, cholinergicGO:0072719.4CHRNA3, CHRNB2, CHRNB4, CHRNB3, CHRNB1
18associative learningGO:0083069.3DRD5, CHRNB2
19cation transportGO:0068128.9CHRNB1, CHRNA2, CHRNB3, CHRNA5, CHRNB4, CHRND
20signal transductionGO:0071658.5CHRNB1, CHRNA2, CHRNB3, CHRNA5, CHRNB4, CHRNB2
21synaptic transmissionGO:0072687.9SLC6A3, CHRNA2, CHRNB3, GABBR2, DRD5, CHRNA3

Molecular functions related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1channel activityGO:0152679.9CHRNB3, CHRNB1
2dopamine bindingGO:0352409.4DRD5, SLC6A3
3drug bindingGO:0081449.3CHRNB2, CHRNA2, CHRNB3, SLC6A3
4ligand-gated ion channel activityGO:0152769.2CHRNB4, CHRNB1, CHRNA3, CHRNB2, CHRNA5
5acetylcholine receptor activityGO:0154649.0CHRNA3, CHRNB2, CHRNB4, CHRNA5, CHRNA2, CHRNB1
6acetylcholine bindingGO:0421668.8CHRNA3, CHRND, CHRNB2, CHRNB3, CHRNA2, CHRNB1
7acetylcholine-activated cation-selective channel activityGO:0048898.4CHRNA3, CHRNB1, CHRND, CHRNB2, CHRNB4, CHRNA5

Products for genes affiliated with Nicotine Dependence

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Sources for Nicotine Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet