MCID: NCT002
MIFTS: 49

Nicotine Dependence malady

Summaries for Nicotine Dependence

Sources:
47OMIM, 33MalaCards
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MalaCards: Nicotine Dependence is related to alcohol dependence and cocaine dependence. An important gene associated with Nicotine Dependence is GABBR2 (gamma-aminobutyric acid (GABA) B receptor, 2), and among its related pathways are Nicotine Activity on Chromaffin Cells and SIDS Susceptibility Pathways. The compounds [125i]epibatidine and [3h]cytisine have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and heart, and related mouse phenotypes are muscle and nervous system.

Description from OMIM:47 188890,612052

Aliases & Classifications for Nicotine Dependence

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 61UMLS
See all sources

Aliases & Descriptions:

nicotine dependence 8 47 10 61


External Ids:

Disease Ontology8 DOID:0050742
OMIM47 188890

Related Diseases for Nicotine Dependence

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Nicotine Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.1ANKK1, TAS2R16, CHRNA5, CHRNB4
2cocaine dependence30.6CHRNB4, CHRNA3, SLC6A3, CHRNA5
3substance dependence30.5SLC6A3, DRD5
4attention deficit hyperactivity disorder30.4CHRNA4, DRD5, SLC6A3
5bipolar disorder30.2DRD5, SLC6A3
6nicotine dependence, protection against30.2SLC6A3, GABBR2
7pathological gambling30.2SLC6A3
8parkinson's disease30.0CHRNA4, SLC6A3
9n syndrome10.6
10cannabis dependence10.4
11anxiety disorder10.4
12nicotine addiction10.4
13panic disorder10.3
14major depressive disorder10.2
15asthma10.2
16wisconsin syndrome10.2
17peripheral vascular disease10.0
18bruxism10.0
19conduct disorder10.0
20thromboangiitis obliterans10.0
21combat disorder10.0
22substance abuse10.0
23vascular disease10.0
24chronic pain10.0
25insomnia10.0
26autosomal dominant nocturnal frontal lobe epilepsy10.0CHRNA4, CHRNA2, CHRNB2
27slow-channel congenital myasthenic syndrome10.0CHRND, CHRNB1, CHRNE
28frontal lobe epilepsy10.0CHRNA2, CHRNA4, CHRNB2
29schizophrenia10.0DRD5, CHRNB2, CHRNA4, SLC6A3
30lung cancer susceptibility 210.0CHRNA5, CHRNA3
31cystic lymphangioma10.0CHRNG, CHRND
32congenital myasthenic syndrome10.0CHRND, CHRNE, CHRNB1
33epilepsy syndrome10.0SLC6A3, CHRNA4, CHRNB2, GABBR2, CHRNA2
34multiple pterygium syndrome lethal type10.0CHRND, CHRNG
35myasthenic syndrome, fast-channel congenital10.0CHRNE, CHRND
36focal epilepsy10.0CHRNA4, CHRNB2
37myasthenia gravis10.0CHRNA4
38congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.0CHRNE, CHRNB1
39drug dependence10.0SLC6A3
40lung cancer10.0CHRNB4, CHRNA3, CHRNA5
41febrile seizures10.0CHRNB2, CHRNA4
42idiopathic generalized epilepsy10.0CHRNB2, CHRNA4
43lewy body dementia10.0SLC6A3
44antisocial personality disorder10.0SLC6A3, ANKK1

Graphical network of the top 20 diseases related to Nicotine Dependence:



Diseases related to nicotine dependence

Clinical Features for Nicotine Dependence

Sources:
47OMIM
See all sources

Clinical features from OMIM:

188890,612052

Drugs & Therapeutics for Nicotine Dependence

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Nicotine Dependence

Drug clinical trials:

Search ClinicalTrials for Nicotine Dependence

Search NIH Clinical Center for Nicotine Dependence

Search CenterWatch for Nicotine Dependence

Genetic Tests for Nicotine Dependence

Anatomical Context for Nicotine Dependence

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Nicotine Dependence:

33
Brain, Lung, Heart, Colon, Fetal brain, Amygdala, Fetal lung

Animal Models for Nicotine Dependence or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Nicotine Dependence:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.4CHRNB4, CHRNG, CHRNA3, CHRNE, SLC6A3, CHRNB2
2MP:000363110.2SLC6A3, DRD5, GABBR2, CHRNB2, CHRNB4, CHRNG
3MP:000538610.1GABBR2, CHRNB2, CHRNB4, CHRNG, CHRNA3, CHRNA4

Publications for Nicotine Dependence

Sources:
51PubMed
See all sources

Articles related to Nicotine Dependence:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Predictors of nicotine dependence symptoms among never-smoking adolescents: a longitudinal analysis from the Nicotine Dependence in Teens Study. (23195923)
2013
2
Alcohol problems as a signal for sensitivity to nicotine dependence and future smoking. (23660243)
2013
3
Time-varying effects of smoking quantity and nicotine dependence on adolescent smoking regularity. (22995764)
2013
4
Translational research in nicotine dependence. (23335115)
2013
5
Physical Activity Moderates the Association Between Nicotine Dependence and Depression Among U.S. Smokers. (24200248)
2013
6
Experimental study on the efficacy of the drug Brizantin in the model of nicotine dependence. (23484195)
2013
7
Early smoking onset and risk for subsequent nicotine dependence: a monozygotic co-twin control study. (23318372)
2013
8
Impaired sleep quality and sleep duration in smokers-results from the German Multicenter Study on Nicotine Dependence. (22913370)
2012
9
Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. (22241830)
2012
10
Difference between the prevalence of symptoms of depression and anxiety in non-diabetic smokers and in patients with type 2 diabetes with and without nicotine dependence. (22906025)
2012
11
Alcohol use disorders, nicotine dependence, and co-occurring mood and anxiety disorders in the United States and South Korea-a cross-national comparison. (21919925)
2012
12
Nicotine Dependence Syndrome Scale and craving: Comparing nicotine-dependent individuals with and without comorbid alcohol dependence. (23857882)
2012
13
Nicotine dependence phenotype, time to first cigarette, and risk of head and neck cancer. (21826643)
2011
14
Older adults and smoking: Characteristics, nicotine dependence and prevalence of DSM-IV 12-month disorders. (20924817)
2011
15
Predictors of persistent nicotine dependence among adults in the United States. (21514748)
2011
16
The alternative five-factor model of personality, nicotine dependence and relapse after treatment for smoking cessation. (21704460)
2011
17
Alcohol use as a signal for sensitivity to nicotine dependence among recent onset smokers. (21232875)
2011
18
The effects of message framing, involvement, and nicotine dependence on anti-smoking public service announcements. (21815740)
2011
19
Social nicotine dependence in Australian dental undergraduate students. (21692786)
2011
20
A latent class analysis of DSM-IV and FagerstrAPm (FTND) criteria for nicotine dependence. (21778154)
2011
21
An audit of the prevalence of recorded nicotine dependence treatment in an Australian psychiatric hospital. (20618273)
2010
22
Preadolescent tobacco smoke exposure leads to acute nicotine dependence but does not affect the rewarding effects of nicotine or nicotine withdrawal in adulthood in rats. (20211642)
2010
23
Nicotine dependence symptoms among recent onset adolescent smokers. (19765916)
2010
24
Physical and psychological nicotine dependence in Greeks: an epidemiological study. (20372672)
2010
25
Replication and extension of association of choline acetyltransferase with nicotine dependence in European and African American smokers. (20383528)
2010
26
A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. (20158304)
2010
27
Spanish adaptation of the NDSS (Nicotine Dependence Syndrome Scale) and assessment of nicotine-dependent individuals at primary care health centers in Spain. (20977042)
2010
28
Does socioeconomic inequality explain ethnic differences in nicotine dependence? Evidence from a New Zealand birth cohort. (20307171)
2010
29
Does smoking cue-induced craving tell us anything important about nicotine dependence? (19426293)
2009
30
Differential item functioning of the English and Chinese versions of the Fagerstrom Test for Nicotine Dependence. (18929444)
2009
31
Sequencing of DSM-IV criteria of nicotine dependence. (19489755)
2009
32
Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. (19564872)
2009
33
Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans. (19290018)
2009
34
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. (19706762)
2009
35
Is the FagerstrAPm Test for Nicotine Dependence a good instrument to assess tobacco use in patients with schizophrenia? (19784502)
2009
36
Relationship between PTSD symptomatology and nicotine dependence severity in crime victims. (18442884)
2008
37
Change in perceived stress, partner support, decisional balance, and self-efficacy following residential nicotine dependence treatment. (18551890)
2008
38
Comparing the validity of the Cigarette Dependence Scale and the FagerstrAPm Test for Nicotine Dependence. (18328641)
2008
39
A twin study of smoking, nicotine dependence, and major depression in men. (18188750)
2008
40
Nicotine dependence symptoms among young never-smokers exposed to secondhand tobacco smoke. (18760878)
2008
41
Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence. (17715344)
2007
42
Genetic variation that contributes to nicotine dependence. (17716221)
2007
43
Symptoms of tobacco dependence after brief intermittent use: the Development and Assessment of Nicotine Dependence in Youth-2 study. (17606835)
2007
44
Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans. (16713586)
2007
45
Nicotine dependence and self-esteem in adolescents with mental disorders. (16839692)
2007
46
Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. (16395295)
2006
47
Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials. (16123753)
2006
48
The influence of genetics on nicotine dependence and the role of pharmacogenetics in treating the smoking habit. (17435909)
2006
49
Methods for smoking cessation and treatment of nicotine dependence. (16878254)
2005
50
Association study of the Epac gene and tobacco smoking and nicotine dependence. (15274052)
2004

Genetic Variations for Nicotine Dependence

Expression for genes affiliated with Nicotine Dependence

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Nicotine Dependence

Search GEO for disease gene expression data for Nicotine Dependence.

Pathways for genes affiliated with Nicotine Dependence

Sources:
38NCBI BioSystems Database, 50PharmGKB, 30KEGG, 52QIAGEN, 54Reactome, 12EMD Millipore
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Pathways related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CHRNB4, CHRNA3
210.4CHRNA4, CHRNB4, CHRNB2
310.4CHRNA4, CHRNA6, CHRNB2
4
Hide members
10.4CHRNB2, CHRNA3, CHRNA6, CHRNA4, CHRNA5
5
Hide members
10.4DRD5, GABBR2, CHRNB2, CHRNB4, CHRNA3, CHRNA6
6
Hide members
10.3CHRNG, CHRNA2, CHRND, CHRNA3, CHRNA6, CHRNA4
7
Hide members
10.3CHRNB2, CHRNB4, CHRNG, CHRNA2, CHRND, CHRNA3
8
Hide members
10.3GABBR2, CHRNB2, CHRNB4, CHRNG, CHRNA2, CHRND
910.3CHRNA4, CHRNB3, CHRNB1, CHRNE, CHRNA5, CHRNA10
10
Hide members
10.3CHRNA10, CHRNA5, CHRNB2, CHRNB4, CHRNG, CHRNA2
11
Hide members
10.2TAS2R16, GABBR2, CHRNB2, CHRNB4, CHRNG, CHRNA2

Compounds for genes affiliated with Nicotine Dependence

Sources:
29IUPHAR, 11DrugBank, 45Novoseek, 50PharmGKB, 60Tocris Bioscience, 24HMDB
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Compounds related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1[125i]epibatidine2910.8CHRNA3, CHRNA2, CHRNA4
2[3h]cytisine2910.8CHRNA2, CHRNA3, CHRNA4
3Pentolinium1110.8CHRNA10, CHRNA3, CHRNB4
4mecamylamine29 45 1112.8CHRNA2, CHRNA3, CHRNA6, CHRNA4
5[3h]epibatidine2910.8CHRNA2, CHRNA3, CHRNA4
6hexamethonium45 2911.8CHRNA4, CHRNA6, CHRNA3, CHRNA2
7α-conotoxin mii2910.8CHRNA3, CHRNA6, CHRNA5
8drugs used in nicotine dependence5010.8CHRNA3, CHRNA5, ANKK1
9rjr 2403 oxalate6010.8CHRNB2, CHRNA4
10sazetidine a dihydrochloride6010.8CHRNB2, CHRNA4
11varenicline45 1111.8CHRNA3, CHRNA6, CHRNA4
12varenicline tartrate6010.8CHRNB2, CHRNA4
13(-)-nicotine ditartrate6010.8CHRNB2, CHRNA4
14α-conotoxin pnia2910.8CHRNA3, CHRNA5
15desformylflustrabromine hydrochloride6010.8CHRNB2, CHRNA4
16α-conotoxin txia2910.8CHRNA3, CHRNA5
17α-conotoxin-gic2910.8CHRNA3, CHRNA5
18nicotine45 50 29 1113.7ANKK1, CHRNA10, CHRNA5, CHRNB3, CHRNA4, CHRNA6
19bupropion45 50 11 2413.7CHRNA3, ANKK1, SLC6A3
20ns1738 2910.7CHRNA3, CHRNA4
21a-867744 2910.7CHRNA3, CHRNA4
22galantamine45 50 1112.7CHRNA10, CHRNB2, CHRNB4, CHRNA5, CHRNE, CHRNB1
23acetylcholine45 50 29 11 2414.7SLC6A3, CHRNA4, CHRNA3, CHRND, CHRNB2
24ly2087101 2910.7CHRNA2, CHRNA4
25Chloroprocaine1110.6SLC6A3, CHRNA10
26olanzapine50 45 29 11 2414.6DRD5, ANKK1, SLC6A3
27Levomethadyl Acetate1110.6CHRNA3, CHRNB4
28procaine45 29 1112.6CHRNA2, SLC6A3
29clozapine45 29 50 1113.5SLC6A3, ANKK1, DRD5
30baclofen45 1111.5GABBR2, SLC6A3
31methadone45 50 1112.4ANKK1, CHRNA10
32methylphenidate45 50 1112.4DRD5, SLC6A3
33pramipexole45 50 29 1113.2SLC6A3, DRD5

GO Terms for genes affiliated with Nicotine Dependence

Sources:
16Gene Ontology
See all sources

Cellular components related to Nicotine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.4CHRNB2, CHRNA5, CHRNE, CHRNB1, CHRNB4, CHRNG
2postsynaptic membraneGO:04521110.3GABBR2, CHRNB2, CHRNB4, CHRNG, CHRNA2, CHRND
3integral to membraneGO:01602110.3CHRNB4, CHRNA2, CHRNA3, CHRNA4, CHRNB3, CHRNA10
4cell junctionGO:03005410.3CHRNA3, CHRNA6, CHRNA4, CHRNB3, CHRNB1, CHRNE
5plasma membraneGO:00588610.1CHRND, CHRNA2, CHRNG, CHRNB4, CHRNB2, GABBR2
6integral to plasma membraneGO:00588710.1DRD5, GABBR2, CHRNB4, CHRNG, CHRNB1, CHRNE

Biological processes related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1behavioral response to nicotineGO:03509510.8CHRNB2, CHRNA5, CHRNB1, CHRNA4, CHRNA3, CHRNB4
2synaptic transmission involved in micturitionGO:06008410.8CHRNA3, CHRNB4, CHRNB2
3locomotory behaviorGO:00762610.7CHRNB2, CHRNB4, CHRNA3, CHRNA4, SLC6A3
4neurological system processGO:05087710.7CHRNB1, CHRNA4, CHRNB2
5regulation of membrane potentialGO:04239110.7CHRNG, CHRND, CHRNA3, CHRNA4, CHRNB1, CHRNE
6synaptic transmission, cholinergicGO:00727110.7CHRNE, CHRNB1, CHRNB3, CHRNA4, CHRNA3, CHRNB4
7regulation of dopamine secretionGO:01405910.7CHRNB2, CHRNA6, CHRNA4
8ion transportGO:00681110.7CHRNA4, CHRNA3, CHRNA2, CHRNB4, CHRNB2
9transportGO:00681010.7CHRNG, CHRND, CHRNA6, CHRNB3, CHRNE, CHRNA5
10response to cocaineGO:04222010.7DRD5, CHRNB2, SLC6A3
11membrane depolarizationGO:05189910.7CHRNB2, CHRNA6, CHRNA4
12muscle contractionGO:00693610.7CHRNG, CHRND, CHRNB1, CHRNE
13response to nicotineGO:03509410.7SLC6A3, CHRNA4, CHRNB2
14regulation of dopamine metabolic processGO:04205310.7CHRNB2, SLC6A3
15signal transductionGO:00716510.6CHRND, CHRNA2, CHRNG, CHRNB4, CHRNB2, CHRNA3
16synaptic transmissionGO:00726810.6DRD5, SLC6A3, CHRNA5, CHRNE, CHRNB3, CHRNA4
17regulation of smooth muscle contractionGO:00694010.6CHRNA3, CHRNB4
18regulation of dendrite morphogenesisGO:04881410.6CHRNB2, CHRNA3
19regulation of action potentialGO:00150810.6CHRNB4, CHRNA4
20cognitionGO:05089010.5CHRNA4, CHRNB2
21associative learningGO:00830610.4CHRNB2, DRD5
22B cell activationGO:04211310.4CHRNA4, CHRNB2
23smooth muscle contractionGO:00693910.4CHRNB2, CHRNB4
24cation transportGO:00681210.1CHRNB1, CHRNE

Molecular functions related to Nicotine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.5SLC6A3, DRD5
2ligand-gated ion channel activityGO:01527610.4CHRNA5, CHRNB1, CHRNA4, CHRNA3, CHRNB4, CHRNB2
3acetylcholine receptor activityGO:01546410.4CHRNA2, CHRNG, CHRNB4, CHRNB2, CHRNA3, CHRNA6
4acetylcholine-activated cation-selective channel activityGO:00488910.4CHRNA10, CHRNA5, CHRNE, CHRNB1, CHRNB3, CHRNA4
5acetylcholine bindingGO:04216610.3CHRNB1, CHRNB3, CHRNA4, CHRNA3, CHRND, CHRNB2
6channel activityGO:01526710.1CHRNB1, CHRNB3, CHRNG

Products for genes affiliated with Nicotine Dependence

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Sources for Nicotine Dependence

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet