MCID: NCT002
MIFTS: 51

Nicotine Dependence malady

Summaries for Nicotine Dependence

About this section
Sources:
46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Nicotine Dependence is related to alcohol dependence and schizophrenia. An important gene associated with Nicotine Dependence is GABBR2 (gamma-aminobutyric acid (GABA) B receptor, 2), and among its related pathways are Nicotine Activity on Chromaffin Cells and SIDS Susceptibility Pathways. The compounds [125i]epibatidine and [3h]cytisine have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and brain, and related mouse phenotypes are muscle and nervous system.

Description from OMIM:46 188890,612052

Aliases & Classifications for Nicotine Dependence

About this section
Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 60UMLS
See all sources

Aliases & Descriptions:

nicotine dependence 8 46 10 60


External Ids:

Disease Ontology8 DOID:0050742
OMIM46 188890

Related Diseases for Nicotine Dependence

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Nicotine Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.1TAS2R16, ANKK1, CHRNA5, CHRNB4
2schizophrenia30.8DRD5, CHRNB2, CHRNA4, SLC6A3
3lung cancer30.6CHRNB4, CHRNA3, CHRNA5
4cocaine dependence30.6CHRNB4, CHRNA3, CHRNA5, SLC6A3
5drug dependence30.5SLC6A3
6substance dependence30.4SLC6A3, DRD5
7attention deficit hyperactivity disorder30.3SLC6A3, CHRNA4, DRD5
8bipolar disorder30.2DRD5, SLC6A3
9nicotine dependence, protection against30.2SLC6A3, GABBR2
10pathological gambling30.2SLC6A3
11parkinson's disease30.0SLC6A3, CHRNA4
12cannabis dependence10.4
13anxiety disorder10.3
14major depressive disorder10.2
15panic disorder10.2
16neuronitis10.1
17asthma10.1
18mood disorder10.1
19opiate dependence10.1
20pancreatic cancer10.1
21pancreatitis10.1
22peripheral vascular disease10.0
23bruxism10.0
24dependent personality disorder10.0
25conduct disorder10.0
26thromboangiitis obliterans10.0
27combat disorder10.0
28chromosomal disease10.0
29colon cancer10.0
30personality disorder10.0
31physical disorder10.0
32pneumonia10.0
33substance abuse10.0
34vascular disease10.0
35nicotine addiction10.0
36autosomal dominant nocturnal frontal lobe epilepsy10.0CHRNB2, CHRNA2, CHRNA4
37frontal lobe epilepsy10.0CHRNB2, CHRNA2, CHRNA4
38slow-channel congenital myasthenic syndrome10.0CHRND, CHRNB1, CHRNE
39cystic lymphangioma10.0CHRND, CHRNG
40congenital myasthenic syndrome10.0CHRND, CHRNB1, CHRNE
41lung cancer susceptibility 210.0CHRNA5, CHRNA3
42epilepsy syndrome10.0GABBR2, CHRNB2, CHRNA2, CHRNA4, SLC6A3
43multiple pterygium syndrome lethal type10.0CHRNG, CHRND
44myasthenic syndrome, fast-channel congenital10.0CHRND, CHRNE
45focal epilepsy10.0CHRNA4, CHRNB2
46myasthenia gravis10.0CHRNA4
47congenital myasthenic syndrome associated with acetylcholine receptor deficiency10.0CHRNB1, CHRNE
48febrile seizures10.0CHRNA4, CHRNB2
49idiopathic generalized epilepsy10.0CHRNB2, CHRNA4
50lewy body dementia10.0SLC6A3

Graphical network of the top 20 diseases related to Nicotine Dependence:



Diseases related to nicotine dependence

Clinical Features for Nicotine Dependence

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

188890,612052

Drugs & Therapeutics for Nicotine Dependence

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Nicotine Dependence

Drug clinical trials:

Search ClinicalTrials for Nicotine Dependence

Search NIH Clinical Center for Nicotine Dependence

Search CenterWatch for Nicotine Dependence

Genetic Tests for Nicotine Dependence

About this section

Anatomical Context for Nicotine Dependence

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Nicotine Dependence:

32
Testes, Lung, Brain, Pituitary, Skeletal muscle, Colon, Heart, Cortex, Monocytes, Ciliary ganglion, Amygdala

Animal Models for Nicotine Dependence or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Nicotine Dependence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.4CHRNB4, CHRNG, CHRNA3, CHRNE, SLC6A3, CHRNB2
2MP:000363110.2SLC6A3, DRD5, GABBR2, CHRNB2, CHRNB4, CHRNG
3MP:000538610.1GABBR2, CHRNB2, CHRNB4, CHRNG, CHRNA3, CHRNA4

Publications for Nicotine Dependence

About this section
Sources:
50PubMed
See all sources

Articles related to Nicotine Dependence:

(show top 50)    (show all 587)
idTitleAuthorsYear
1
Nicotine dependence produces hyperalgesia: Role of corticotropin-releasing factor-1 receptors (CRF1Rs) in the central amygdala (CeA). (24107576)
2014
2
Real-time fMRI in the treatment of nicotine dependence: a conceptual review and pilot studies. (22564200)
2013
3
Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations. (24253422)
2013
4
Nominal association with CHRNA4 variants and nicotine dependence. (23350800)
2013
5
Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample. (23752247)
2013
6
Prevalence and correlates of heavy smoking and nicotine dependence in adolescents with bipolar and cannabis use disorders. (23684537)
2013
7
Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. (22006218)
2012
8
ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. (22377092)
2012
9
Smoking among patients hospitalized at a university hospital in the south of Brazil: prevalence, degree of nicotine dependence, and motivational stage of change. (22407043)
2012
10
Cigarette smoking, nicotine dependence and anxiety disorders: a systematic review of population-based, epidemiological studies. (23083451)
2012
11
Sex differences in nicotine dependence among addictions clients accessing a smoking cessation programme in Vancouver, British Columbia, Canada. (22077343)
2012
12
Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort. (22223462)
2012
13
A new nicotine dependence score and a new scale assessing patient comfort during smoking cessation treatment. (23288122)
2012
14
The nicotine dependence phenotype, time to first cigarette, and larynx cancer risk. (22367700)
2012
15
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. (22570471)
2012
16
Nicotine dependence, abuse and craving: dimensionality in an Israeli sample. (21545668)
2011
17
Adenosine A2A receptor induces protein kinase A-dependent functional modulation of human (alpha)3(beta)4 nicotinic receptor. (21486776)
2011
18
Breaking free from nicotine dependence. A combination of strategies boosts the odds of success. (21786468)
2011
19
Nicotine dependence and gender differences in smokers accessing community mental health services. (21418435)
2011
20
The relationship of childhood trauma to nicotine dependence in pregnant smokers. (21928869)
2011
21
An investigation of social and pharmacological exposure to secondhand tobacco smoke as possible predictors of perceived nicotine dependence, smoking susceptibility, and smoking expectancies among never-smoking youth. (21622492)
2011
22
Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity. (20725741)
2010
23
Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice. (20576796)
2010
24
Nicotine dependence symptoms among recent onset adolescent smokers. (19765916)
2010
25
Physical and psychological nicotine dependence in Greeks: an epidemiological study. (20372672)
2010
26
Significant association of glutamate receptor, ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers. (20084518)
2010
27
Association of adolescent symptoms of depression and anxiety with daily smoking and nicotine dependence in young adulthood: findings from a 10-year longitudinal study. (20707783)
2010
28
Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence. (20147892)
2010
29
Failure of hospital employees to comply with smoke-free policy is associated with nicotine dependence and motives for smoking: a descriptive cross-sectional study at a teaching hospital in the United Kingdom. (19604348)
2009
30
Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. (19564872)
2009
31
The role of cystine-glutamate exchange in nicotine dependence in rats and humans. (19103434)
2009
32
Nicotine dependence and psychiatric disorders among young males in Singapore. (19633276)
2009
33
Adolescents' rationalizations to continue smoking: the role of disengagement beliefs and nicotine dependence in smoking cessation. (19185429)
2009
34
Nicotine dependence, psychological distress and personality traits as possible predictors of smoking cessation. Results of a double-blind study with nicotine patch. (18804918)
2009
35
Nicotine dependence mediates the relations between insomnia and both panic and posttraumatic stress disorder in the NCS-R sample. (17935215)
2008
36
Effects of inattention and hyperactivity/impulsivity symptoms on development of nicotine dependence from mid adolescence to young adulthood. (17956929)
2008
37
A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. (18618000)
2008
38
A latent class analysis of nicotine-dependence criteria and use of alternate tobacco. (18781246)
2008
39
Genetics of nicotine dependence and pharmacotherapy. (17888884)
2008
40
Correlates of cigarette smoking during pregnancy and its genetic and environmental overlap with nicotine dependence. (18418779)
2008
41
Intermediacy and gene-environment interaction: the example of CHRNA5-A3 region, smoking, nicotine dependence, and lung cancer. (18957674)
2008
42
Novel G423S mutation of human alpha7 nicotinic receptor promotes agonist-induced desensitization by a protein kinase C-dependent mechanism. (17132684)
2007
43
Factorial and convergent validity of nicotine dependence measures in adolescents: toward a multidimensional approach. (17978984)
2007
44
The role of the TPH1 and TPH2 genes for nicotine dependence: a genetic association study in two different age cohorts. (17986837)
2007
45
Susceptibility to nicotine dependence: the Development and Assessment of Nicotine Dependence in Youth 2 study. (17908753)
2007
46
Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence. (16874522)
2006
47
Cost-effectiveness of pharmacotherapies for nicotine dependence in primary care settings: a multinational comparison. (16728744)
2006
48
Methods for smoking cessation and treatment of nicotine dependence. (16878254)
2005
49
Assessing the impact of a nurse-led health education intervention for people with peripheral vascular disease who smoke: the use of physiological markers, nicotine dependence and withdrawal. (11137727)
2001
50
Two mutations linked to nocturnal frontal lobe epilepsy cause use-dependent potentiation of the nicotinic ACh response. (9824708)
1998

Genetic Variations for Nicotine Dependence

About this section

Expression for genes affiliated with Nicotine Dependence

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Nicotine Dependence

Search GEO for disease gene expression data for Nicotine Dependence.

Pathways for genes affiliated with Nicotine Dependence

About this section
Sources:
37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 51QIAGEN, 53Reactome, 12EMD Millipore
See all sources

Pathways related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CHRNB4, CHRNA3
210.4CHRNA4, CHRNB4, CHRNB2
310.4CHRNA4, CHRNA6, CHRNB2
4
Hide members
10.4CHRNB2, CHRNA3, CHRNA6, CHRNA4, CHRNA5
5
Hide members
10.4DRD5, GABBR2, CHRNB2, CHRNB4, CHRNA3, CHRNA6
6
Hide members
10.3CHRNG, CHRNA2, CHRND, CHRNA3, CHRNA6, CHRNA4
7
Hide members
10.3CHRNB2, CHRNB4, CHRNG, CHRNA2, CHRND, CHRNA3
8
Hide members
10.3GABBR2, CHRNB2, CHRNB4, CHRNG, CHRNA2, CHRND
910.3CHRNA4, CHRNB3, CHRNB1, CHRNE, CHRNA5, CHRNA10
10
Hide members
10.3CHRNA10, CHRNA5, CHRNB2, CHRNB4, CHRNG, CHRNA2
11
Hide members
10.2TAS2R16, GABBR2, CHRNB2, CHRNB4, CHRNG, CHRNA2

Compounds for genes affiliated with Nicotine Dependence

About this section
Sources:
28IUPHAR, 11DrugBank, 44Novoseek, 49PharmGKB, 59Tocris Bioscience, 24HMDB
See all sources

Compounds related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1[125i]epibatidine2810.8CHRNA3, CHRNA2, CHRNA4
2[3h]cytisine2810.8CHRNA2, CHRNA3, CHRNA4
3Pentolinium1110.8CHRNA10, CHRNA3, CHRNB4
4mecamylamine28 44 1112.8CHRNA2, CHRNA3, CHRNA6, CHRNA4
5[3h]epibatidine2810.8CHRNA2, CHRNA3, CHRNA4
6hexamethonium44 2811.8CHRNA4, CHRNA6, CHRNA3, CHRNA2
7α-conotoxin mii2810.8CHRNA3, CHRNA6, CHRNA5
8drugs used in nicotine dependence4910.8CHRNA3, CHRNA5, ANKK1
9rjr 2403 oxalate5910.8CHRNB2, CHRNA4
10sazetidine a dihydrochloride5910.8CHRNB2, CHRNA4
11varenicline44 1111.8CHRNA3, CHRNA6, CHRNA4
12varenicline tartrate5910.8CHRNB2, CHRNA4
13(-)-nicotine ditartrate5910.8CHRNB2, CHRNA4
14α-conotoxin pnia2810.8CHRNA3, CHRNA5
15desformylflustrabromine hydrochloride5910.8CHRNB2, CHRNA4
16α-conotoxin txia2810.8CHRNA3, CHRNA5
17α-conotoxin-gic2810.8CHRNA3, CHRNA5
18nicotine44 49 28 1113.7ANKK1, CHRNA10, CHRNA5, CHRNB3, CHRNA4, CHRNA6
19bupropion44 49 11 2413.7CHRNA3, ANKK1, SLC6A3
20ns1738 2810.7CHRNA3, CHRNA4
21a-867744 2810.7CHRNA3, CHRNA4
22galantamine44 49 1112.7CHRNA10, CHRNB2, CHRNB4, CHRNA5, CHRNE, CHRNB1
23acetylcholine44 49 28 11 2414.7SLC6A3, CHRNA4, CHRNA3, CHRND, CHRNB2
24ly2087101 2810.7CHRNA2, CHRNA4
25Chloroprocaine1110.6SLC6A3, CHRNA10
26olanzapine49 44 28 11 2414.6DRD5, ANKK1, SLC6A3
27Levomethadyl Acetate1110.6CHRNA3, CHRNB4
28procaine44 28 1112.6CHRNA2, SLC6A3
29clozapine44 28 49 1113.5SLC6A3, ANKK1, DRD5
30baclofen44 1111.5GABBR2, SLC6A3
31methadone44 49 1112.4ANKK1, CHRNA10
32methylphenidate44 49 1112.4DRD5, SLC6A3
33pramipexole44 49 28 1113.2SLC6A3, DRD5

GO Terms for genes affiliated with Nicotine Dependence

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Nicotine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00589210.4CHRNB2, CHRNA5, CHRNE, CHRNB1, CHRNB4, CHRNG
2postsynaptic membraneGO:04521110.3GABBR2, CHRNB2, CHRNB4, CHRNG, CHRNA2, CHRND
3integral to membraneGO:01602110.3CHRNB4, CHRNA2, CHRNA3, CHRNA4, CHRNB3, CHRNA10
4cell junctionGO:03005410.3CHRNA3, CHRNA6, CHRNA4, CHRNB3, CHRNB1, CHRNE
5plasma membraneGO:00588610.1CHRND, CHRNA2, CHRNG, CHRNB4, CHRNB2, GABBR2
6integral to plasma membraneGO:00588710.1DRD5, GABBR2, CHRNB4, CHRNG, CHRNB1, CHRNE

Biological processes related to Nicotine Dependence according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1behavioral response to nicotineGO:03509510.8CHRNB2, CHRNA5, CHRNB1, CHRNA4, CHRNA3, CHRNB4
2synaptic transmission involved in micturitionGO:06008410.8CHRNA3, CHRNB4, CHRNB2
3locomotory behaviorGO:00762610.7CHRNB2, CHRNB4, CHRNA3, CHRNA4, SLC6A3
4neurological system processGO:05087710.7CHRNB1, CHRNA4, CHRNB2
5regulation of membrane potentialGO:04239110.7CHRNG, CHRND, CHRNA3, CHRNA4, CHRNB1, CHRNE
6synaptic transmission, cholinergicGO:00727110.7CHRNE, CHRNB1, CHRNB3, CHRNA4, CHRNA3, CHRNB4
7regulation of dopamine secretionGO:01405910.7CHRNB2, CHRNA6, CHRNA4
8ion transportGO:00681110.7CHRNA4, CHRNA3, CHRNA2, CHRNB4, CHRNB2
9transportGO:00681010.7CHRNG, CHRND, CHRNA6, CHRNB3, CHRNE, CHRNA5
10response to cocaineGO:04222010.7DRD5, CHRNB2, SLC6A3
11membrane depolarizationGO:05189910.7CHRNB2, CHRNA6, CHRNA4
12muscle contractionGO:00693610.7CHRNG, CHRND, CHRNB1, CHRNE
13response to nicotineGO:03509410.7SLC6A3, CHRNA4, CHRNB2
14regulation of dopamine metabolic processGO:04205310.7CHRNB2, SLC6A3
15signal transductionGO:00716510.6CHRND, CHRNA2, CHRNG, CHRNB4, CHRNB2, CHRNA3
16synaptic transmissionGO:00726810.6DRD5, SLC6A3, CHRNA5, CHRNE, CHRNB3, CHRNA4
17regulation of smooth muscle contractionGO:00694010.6CHRNA3, CHRNB4
18regulation of dendrite morphogenesisGO:04881410.6CHRNB2, CHRNA3
19regulation of action potentialGO:00150810.6CHRNB4, CHRNA4
20cognitionGO:05089010.5CHRNA4, CHRNB2
21associative learningGO:00830610.4CHRNB2, DRD5
22B cell activationGO:04211310.4CHRNA4, CHRNB2
23smooth muscle contractionGO:00693910.4CHRNB2, CHRNB4
24cation transportGO:00681210.1CHRNB1, CHRNE

Molecular functions related to Nicotine Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.5SLC6A3, DRD5
2ligand-gated ion channel activityGO:01527610.4CHRNA5, CHRNB1, CHRNA4, CHRNA3, CHRNB4, CHRNB2
3acetylcholine receptor activityGO:01546410.4CHRNA2, CHRNG, CHRNB4, CHRNB2, CHRNA3, CHRNA6
4acetylcholine-activated cation-selective channel activityGO:00488910.4CHRNA10, CHRNA5, CHRNE, CHRNB1, CHRNB3, CHRNA4
5acetylcholine bindingGO:04216610.3CHRNB1, CHRNB3, CHRNA4, CHRNA3, CHRND, CHRNB2
6channel activityGO:01526710.1CHRNB1, CHRNB3, CHRNG

Products for genes affiliated with Nicotine Dependence

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nicotine Dependence

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet