MCID: NCT008
MIFTS: 33

Nicotine Dependence, Protection Against malady

Genetic diseases (common) category

Aliases & Classifications for Nicotine Dependence, Protection Against

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Aliases & Descriptions for Nicotine Dependence, Protection Against:

Name: Nicotine Dependence, Protection Against 46
Nicotine Dependence 46 8 10 61
Nicotine Addiction, Protection from 46 9
 
Tobacco Addiction 46 22
Nicotine Addiction 46
Smoking Habit 44


Classifications:



External Ids:

OMIM46 188890
Disease Ontology8 DOID:0050742

Summaries for Nicotine Dependence, Protection Against

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MalaCards based summary: Nicotine Dependence, Protection Against, also known as nicotine dependence, is related to lung cancer and attention deficit-hyperactivity disorder. An important gene associated with Nicotine Dependence, Protection Against is SLC6A3 (solute carrier family 6 (neurotransmitter transporter), member 3), and among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. The compounds benzphetamine and debrisoquine have been mentioned in the context of this disorder. Related mouse phenotype integument.

Description from OMIM:46 188890

Related Diseases for Nicotine Dependence, Protection Against

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Graphical network of the top 20 diseases related to Nicotine Dependence, Protection Against:



Diseases related to nicotine dependence, protection against

Symptoms for Nicotine Dependence, Protection Against

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Symptoms by clinical synopsis from OMIM:

188890

Clinical features from OMIM:

188890

Drugs & Therapeutics for Nicotine Dependence, Protection Against

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Drug clinical trials:

Search ClinicalTrials for Nicotine Dependence, Protection Against

Search NIH Clinical Center for Nicotine Dependence, Protection Against

Genetic Tests for Nicotine Dependence, Protection Against

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Genetic tests related to Nicotine Dependence, Protection Against:

id Genetic test Affiliating Genes
1 Tobacco Addiction, Susceptibility to22

Anatomical Context for Nicotine Dependence, Protection Against

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Animal Models for Nicotine Dependence, Protection Against or affiliated genes

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MGI Mouse Phenotypes related to Nicotine Dependence, Protection Against:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.9SLC6A3, GABBR2, CHRNA4

Publications for Nicotine Dependence, Protection Against

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Variations for Nicotine Dependence, Protection Against

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Clinvar genetic disease variations for Nicotine Dependence, Protection Against:

5
id Gene Variation Type Significance SNP ID Assembly Location
1GABBR2NM_005458.7(GABBR2): c.360A> G (p.Ala120=)single nucleotide variantrisk factorrs3750344GRCh37Chr 9, 101340316: 101340316
2GABBR2GABABR2, HAPLOTYPE, TATA (rs1435252, rs3780422, rs2779562, rs3750344)undetermined variantrisk factor

Expression for genes affiliated with Nicotine Dependence, Protection Against

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Search GEO for disease gene expression data for Nicotine Dependence, Protection Against.

Pathways for genes affiliated with Nicotine Dependence, Protection Against

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Compounds for genes affiliated with Nicotine Dependence, Protection Against

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Sources:
44Novoseek, 11DrugBank, 50PharmGKB, 28IUPHAR, 24HMDB, 1BitterDB
See all sources

Compounds related to Nicotine Dependence, Protection Against according to GeneCards Suite gene sharing:

(show all 21)
idCompoundScoreTop Affiliating Genes
1benzphetamine44 1110.8CYP2A6, SLC6A3
2debrisoquine44 5010.8CYP2A6, SLC6A3
3baclofen44 1110.8SLC6A3, GABBR2
4selegiline44 1110.8CYP2A6, SLC6A3
5nortriptyline50 44 28 1112.8SLC6A3, CYP2A6
6bupropion50 44 24 1112.8SLC6A3, CYP2A6
7desipramine44 50 1111.7CYP2A6, SLC6A3
8amphetamine44 50 1111.7SLC6A3, CYP2A6
9amobarbital44 1110.7CHRNA4, CYP2A6
10citalopram44 50 24 1112.6SLC6A3, CYP2A6
11hexobarbital44 1110.6CHRNA4, CYP2A6
12imipramine44 28 50 24 1113.6CYP2A6, SLC6A3
13clozapine44 28 50 1112.6SLC6A3, CYP2A6
14gaba449.4GABBR2, SLC6A3
15coumarin44 1 50 2412.4CYP2A6, CYP2A
16potassium44 24 1111.3GABBR2, CHRNA4
17nicotine44 28 50 1112.2CYP2A6, CHRNA4, SLC6A3
18acetylcholine44 50 28 24 1113.1SLC6A3, CHRNA4
19dopamine44 28 24 1112.1SLC6A3, CHRNA4, CYP2A6
20glutamate449.0SLC6A3, GABBR2, CYP2A6
21phenobarbital44 28 50 1111.9CHRNA4, CYP2A, CYP2A6

GO Terms for genes affiliated with Nicotine Dependence, Protection Against

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Cellular components related to Nicotine Dependence, Protection Against according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430259.4SLC6A3, CHRNA4
2postsynaptic membraneGO:00452119.0GABBR2, CHRNA4

Biological processes related to Nicotine Dependence, Protection Against according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1locomotory behaviorGO:00076269.4SLC6A3, CHRNA4
2response to nicotineGO:00350949.3SLC6A3, CHRNA4
3synaptic transmissionGO:00072688.6SLC6A3, GABBR2, CHRNA4

Sources for Nicotine Dependence, Protection Against

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet