MCID: NCT008
MIFTS: 33

Nicotine Dependence, Protection Against malady

Genetic diseases (common) category

Aliases & Classifications for Nicotine Dependence, Protection Against

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Sources:
45OMIM, 22GTR, 9Disease Ontology, 11DISEASES, 60UMLS, 10diseasecard, 43Novoseek
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Nicotine Dependence, Protection Against, Aliases & Descriptions:

Name: Nicotine Dependence, Protection Against 45
Nicotine Dependence 45 9 11 60
Nicotine Addiction, Protection from 45 10
 
Tobacco Addiction 45 22
Nicotine Addiction 45
Smoking Habit 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

OMIM45 188890
Disease Ontology9 DOID:0050742

Summaries for Nicotine Dependence, Protection Against

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MalaCards based summary: Nicotine Dependence, Protection Against, also known as nicotine dependence, is related to lung cancer and attention deficit-hyperactivity disorder. An important gene associated with Nicotine Dependence, Protection Against is SLC6A3 (solute carrier family 6 (neurotransmitter transporter), member 3), and among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. The compounds benzphetamine and debrisoquine have been mentioned in the context of this disorder. Related mouse phenotype integument.

Description from OMIM:45 188890

Related Diseases for Nicotine Dependence, Protection Against

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Graphical network of the top 20 diseases related to Nicotine Dependence, Protection Against:



Diseases related to nicotine dependence, protection against

Symptoms for Nicotine Dependence, Protection Against

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Symptoms by clinical synopsis from OMIM:

188890

Clinical features from OMIM:

188890

Drugs & Therapeutics for Nicotine Dependence, Protection Against

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Drug clinical trials:

Search ClinicalTrials for Nicotine Dependence, Protection Against

Search NIH Clinical Center for Nicotine Dependence, Protection Against

Genetic Tests for Nicotine Dependence, Protection Against

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Genetic tests related to Nicotine Dependence, Protection Against:

id Genetic test Affiliating Genes
1 Tobacco Addiction, Susceptibility to22

Anatomical Context for Nicotine Dependence, Protection Against

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Animal Models for Nicotine Dependence, Protection Against or affiliated genes

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MGI Mouse Phenotypes related to Nicotine Dependence, Protection Against:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.9SLC6A3, GABBR2, CHRNA4

Publications for Nicotine Dependence, Protection Against

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Variations for Nicotine Dependence, Protection Against

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Clinvar genetic disease variations for Nicotine Dependence, Protection Against:

6
id Gene Variation Type Significance SNP ID Assembly Location
1GABBR2NM_005458.7(GABBR2): c.360A> G (p.Ala120=)single nucleotide variantrisk factorrs3750344GRCh37Chr 9, 101340316: 101340316
2GABBR2GABABR2, HAPLOTYPE, TATA (rs1435252, rs3780422, rs2779562, rs3750344)undetermined variantrisk factor

Expression for genes affiliated with Nicotine Dependence, Protection Against

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Search GEO for disease gene expression data for Nicotine Dependence, Protection Against.

Pathways for genes affiliated with Nicotine Dependence, Protection Against

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Compounds for genes affiliated with Nicotine Dependence, Protection Against

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Sources:
43Novoseek, 12DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Nicotine Dependence, Protection Against according to GeneCards Suite gene sharing:

(show all 21)
idCompoundScoreTop Affiliating Genes
1benzphetamine43 1210.8CYP2A6, SLC6A3
2debrisoquine43 4910.8CYP2A6, SLC6A3
3baclofen43 1210.8SLC6A3, GABBR2
4selegiline43 1210.8CYP2A6, SLC6A3
5nortriptyline49 43 28 1212.8SLC6A3, CYP2A6
6bupropion49 43 24 1212.8SLC6A3, CYP2A6
7desipramine43 49 1211.7CYP2A6, SLC6A3
8amphetamine43 49 1211.7SLC6A3, CYP2A6
9amobarbital43 1210.7CHRNA4, CYP2A6
10citalopram43 49 24 1212.6SLC6A3, CYP2A6
11hexobarbital43 1210.6CHRNA4, CYP2A6
12imipramine43 28 49 24 1213.6CYP2A6, SLC6A3
13clozapine43 28 49 1212.6SLC6A3, CYP2A6
14gaba439.4GABBR2, SLC6A3
15coumarin43 2 49 2412.4CYP2A6, CYP2A
16potassium43 24 1211.3GABBR2, CHRNA4
17nicotine43 28 49 1212.2CYP2A6, CHRNA4, SLC6A3
18acetylcholine43 49 28 24 1213.1SLC6A3, CHRNA4
19dopamine43 28 24 1212.1SLC6A3, CHRNA4, CYP2A6
20glutamate439.0SLC6A3, GABBR2, CYP2A6
21phenobarbital43 28 49 1211.9CHRNA4, CYP2A, CYP2A6

GO Terms for genes affiliated with Nicotine Dependence, Protection Against

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Cellular components related to Nicotine Dependence, Protection Against according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430259.4SLC6A3, CHRNA4
2postsynaptic membraneGO:00452119.0GABBR2, CHRNA4

Biological processes related to Nicotine Dependence, Protection Against according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1locomotory behaviorGO:00076269.4SLC6A3, CHRNA4
2response to nicotineGO:00350949.3SLC6A3, CHRNA4
3synaptic transmissionGO:00072688.6SLC6A3, GABBR2, CHRNA4

Products for genes affiliated with Nicotine Dependence, Protection Against

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Sources for Nicotine Dependence, Protection Against

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet