MCID: NCT008
MIFTS: 42

Nicotine Dependence, Protection Against

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Nicotine Dependence, Protection Against

MalaCards integrated aliases for Nicotine Dependence, Protection Against:

Name: Nicotine Dependence, Protection Against 54
Nicotine Dependence 54 12 29 14 69
Tobacco Use Disorder 12 29 42
Nicotine Addiction, Protection from 54 13
Tobacco Addiction, Susceptibility to 29
Nicotine Addiction 54
Smoking Habit 52

Characteristics:

OMIM:

54
Inheritance:
genetic factors seem to contribute only in light smokers and heavy smokers


Classifications:



External Ids:

OMIM 54 188890
Disease Ontology 12 DOID:0050742
MeSH 42 D014029
NCIt 47 C54203
SNOMED-CT 64 56294008
UMLS 69 C0028043

Summaries for Nicotine Dependence, Protection Against

MalaCards based summary : Nicotine Dependence, Protection Against, also known as nicotine dependence, is related to schizophrenia and personality disorder. An important gene associated with Nicotine Dependence, Protection Against is GABBR2 (Gamma-Aminobutyric Acid Type B Receptor Subunit 2), and among its related pathways/superpathways are Peptide ligand-binding receptors and Nanog in Mammalian ESC Pluripotency. The drugs Nicotine and Varenicline have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and homeostasis/metabolism

Description from OMIM: 188890

Related Diseases for Nicotine Dependence, Protection Against

Diseases related to Nicotine Dependence, Protection Against via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Related Disease Score Top Affiliating Genes
1 schizophrenia 30.1 CHRNA4 CHRNA7 CHRNB2 COMT DRD2 MAOA
2 personality disorder 29.9 CHRNA4 COMT DRD2 MAOA OPRM1 SLC6A3
3 lung cancer susceptibility 2 11.0
4 epilepsy, nocturnal frontal lobe, 3 10.9 CHRNA4 CHRNB2
5 edict syndrome 10.9 CHRNA3 CHRNA5
6 hyperekplexia 1 10.8 CHRNA4 CHRNB2
7 pyromania 10.8 DRD2 MAOA SLC6A3
8 simple chronic conjunctivitis 10.8 CHRNA3 CHRNA5 CHRNB3
9 pauci-immune glomerulonephritis with anca 10.8 COMT DRD2 MAOA
10 ovarian cystadenocarcinoma 10.7 GSTM1 GSTT1 SLC6A3
11 myopathy, distal, with early respiratory failure, autosomal dominant 10.7 COMT SLC6A3 TPH1
12 anosognosia 10.7 ANKK1 COMT DRD2
13 perinatal necrotizing enterocolitis 10.7 COMT DRD2 SLC6A3
14 ring chromosome 14 syndrome 10.7 COMT MAOA
15 renpenning syndrome 10.7 COMT MAOA TPH1
16 hemorrhagic cystitis 10.7 COMT DRD2 MAOA SLC6A3
17 rhinoscleroma 10.7 COMT DRD2
18 obsessive-compulsive personality disorder 10.7 COMT MAOA TPH1
19 suppurative periapical periodontitis 10.7 DRD2 OPRM1 TPH1
20 hereditary multiple exostoses 10.7 COMT DRD2 MAOA
21 postencephalitic parkinson disease 10.7 DRD2 MAOA TPH1
22 intracranial cavernous angioma 10.7 DRD2 SLC6A3
23 cyclotropia 10.7 COMT OPRM1
24 keratosis 10.7 COMT MAOA TPH1
25 colon mucinous adenocarcinoma 10.7 COMT DRD2 MAOA SLC6A3
26 placenta accreta 10.7 COMT OPRM1 TPH1
27 osteogenesis imperfecta, type ix 10.6 COMT DRD2 SLC6A3
28 pervasive developmental disorder 10.6 COMT OPRM1 SLC6A3
29 eosinophilia-myalgia syndrome 10.6 ANKK1 DRD2 OPRM1 SLC6A3
30 asbestos intoxication 10.6 GSTM1 GSTT1
31 bone cancer 10.6 CHRNA4 CHRNA7 CHRNB2 OPRM1
32 teebi kaurah syndrome 10.6 COMT DRD2
33 partial motor epilepsy 10.6 COMT DRD2 MAOA TPH1
34 hepatopulmonary syndrome 10.6 COMT DRD2 SLC6A3 TPH1
35 may-hegglin anomaly 10.5 COMT MAOA TPH1
36 bone fracture 10.5 COMT DRD2 SLC6A3 TPH1
37 carotid stenosis 10.5 COMT DRD2 MAOA SLC6A3 TPH1
38 hepatitis d 10.5 COMT DRD2 MAOA SLC6A3 TPH1
39 tongue disease 10.5 ANKK1 COMT DRD2 MAOA SLC6A3
40 aicardi-goutieres syndrome 2 10.5 COMT DRD2 MAOA SLC6A3 TPH1
41 chronic conjunctivitis 10.4 CHRNA7 COMT DRD2 SLC6A3 TPH1
42 dementia - subcortical 10.4 COMT OPRM1
43 hyperekplexia 10.3 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNB2 CHRNB3
44 hallucinogen dependence 10.3 ANKK1 CHRNA6 CHRNB3 DRD2 OPRM1
45 acute female pelvic peritonitis 10.3 CHRNA3 CHRNA5 CHRNB3 DRD2 OPRM1 SLC6A3
46 parkinson disease, late-onset 10.3 CHRNA4 COMT DRD2 MAOA SLC6A3 TPH1
47 sexual disorder 10.3 CHRNA4 CHRNA7 COMT DRD2 MAOA SLC6A3
48 cecal benign neoplasm 10.3 ANKK1 COMT DRD2 MAOA SLC6A3 TPH1
49 chitty hall webb syndrome 10.2 COMT TPH1
50 heroin dependence 10.0 CHRNA3 CHRNA5 CHRNB4 DRD2 GSTM1 MAOA

Graphical network of the top 20 diseases related to Nicotine Dependence, Protection Against:



Diseases related to Nicotine Dependence, Protection Against

Symptoms & Phenotypes for Nicotine Dependence, Protection Against

Symptoms via clinical synopsis from OMIM:

54

Misc:
smoking habit


Clinical features from OMIM:

188890

MGI Mouse Phenotypes related to Nicotine Dependence, Protection Against:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 AKR1B10 CHRNA3 CHRNA4 CHRNA5 CHRNA7 CHRNB2
2 homeostasis/metabolism MP:0005376 9.93 CHRNA3 CHRNA4 CHRNA7 CHRNB2 CHRNB4 COMT
3 integument MP:0010771 9.56 CHRNA4 CHRNB2 CHRNB4 DRD2 GABBR2 OPRM1
4 nervous system MP:0003631 9.44 CHRNB4 COMT DRD2 GABBR2 MAOA OPRM1

Drugs & Therapeutics for Nicotine Dependence, Protection Against

Drugs for Nicotine Dependence, Protection Against (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotine Approved Phase 3 54-11-5 942 89594
2
Varenicline Approved, Investigational Phase 3 249296-44-4 5310966

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Examination of Sleep, Smoking Cessation, and Cardiovascular Health Recruiting NCT02941718 Phase 3

Search NIH Clinical Center for Nicotine Dependence, Protection Against

Cochrane evidence based reviews: tobacco use disorder

Genetic Tests for Nicotine Dependence, Protection Against

Genetic tests related to Nicotine Dependence, Protection Against:

id Genetic test Affiliating Genes
1 Tobacco Addiction, Susceptibility to 29
2 Nicotine Dependence 29
3 Tobacco Use Disorder 29

Anatomical Context for Nicotine Dependence, Protection Against

Publications for Nicotine Dependence, Protection Against

Variations for Nicotine Dependence, Protection Against

ClinVar genetic disease variations for Nicotine Dependence, Protection Against:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GABBR2 GABABR2, HAPLOTYPE, TATA (rs1435252, rs3780422, rs2779562, rs3750344) undetermined variant risk factor

Copy number variations for Nicotine Dependence, Protection Against from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 256991 9 99300000 102600000 Gain or loss GPR51 Nicotine dependence

Expression for Nicotine Dependence, Protection Against

Search GEO for disease gene expression data for Nicotine Dependence, Protection Against.

Pathways for Nicotine Dependence, Protection Against

Pathways related to Nicotine Dependence, Protection Against according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
2
Show member pathways
13.13 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
3
Show member pathways
13.05 AKR1B10 COMT CYP2A6 GSTM1 GSTT1 MAOA
4
Show member pathways
12.48 CHRNA7 CYP2A6 GSTM1 GSTT1 MAOA
5 12.39 COMT GABBR2 OPRM1 TPH1
6
Show member pathways
12.32 CHRNA3 CHRNA4 CHRNA6 CHRNA7 CHRNB2 CHRNB4
7
Show member pathways
12.26 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
8 11.95 CHRNA4 CHRNA7 CHRNB2 CHRNB4 MAOA TPH1
9
Show member pathways
11.8 DRD2 MAOA SLC6A3
10
Show member pathways
11.64 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNB2 DRD2
11
Show member pathways
11.6 CYP2A6 GSTM1 GSTT1
12 11.22 CHRNA4 CHRNA6 CHRNA7 CHRNB2
13
Show member pathways
11.06 COMT MAOA SLC6A3
14 10.99 CYP2A6 GSTM1 GSTT1
15
Show member pathways
10.92 COMT MAOA TPH1
16 10.69 COMT MAOA
17
Show member pathways
10.68 COMT MAOA
18
Show member pathways
10.55 AKR1B10 CYP2A6

GO Terms for Nicotine Dependence, Protection Against

Cellular components related to Nicotine Dependence, Protection Against according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.91 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
2 dendrite GO:0030425 9.83 CHRNA3 CHRNA4 COMT DRD2 OPRM1
3 synapse GO:0045202 9.81 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
4 neuron projection GO:0043005 9.8 CHRNB3 CHRNB4 GABBR2 OPRM1 SLC6A3 TPH1
5 axon GO:0030424 9.78 COMT DRD2 OPRM1 SLC6A3
6 postsynaptic membrane GO:0045211 9.65 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
7 plasma membrane raft GO:0044853 9.54 CHRNA3 CHRNA7 CHRNB2
8 acetylcholine-gated channel complex GO:0005892 9.23 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
9 integral component of membrane GO:0016021 10.28 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
10 plasma membrane GO:0005886 10.27 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2

Biological processes related to Nicotine Dependence, Protection Against according to GeneCards Suite gene sharing:

(show all 45)
id Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.94 CHRNA4 CHRNA7 CHRNB2 DRD2
2 locomotory behavior GO:0007626 9.91 CHRNA3 CHRNA4 CHRNB2 CHRNB4 DRD2 OPRM1
3 response to ethanol GO:0045471 9.87 CHRNB2 DRD2 OPRM1 SLC6A3
4 regulation of postsynaptic membrane potential GO:0060078 9.87 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2 CHRNB3
5 response to cocaine GO:0042220 9.85 CHRNB2 DRD2 OPRM1 SLC6A3
6 protein heterooligomerization GO:0051291 9.84 CHRNB2 CHRNB3 CHRNB4
7 regulation of membrane potential GO:0042391 9.83 CHRNA3 CHRNA4 CHRNB2 CHRNB4
8 sensory perception of pain GO:0019233 9.82 CHRNA4 CHRNB2 OPRM1
9 cognition GO:0050890 9.81 CHRNA4 CHRNA7 CHRNB2
10 regulation of dopamine secretion GO:0014059 9.81 CHRNA4 CHRNA6 CHRNB2 DRD2
11 response to nicotine GO:0035094 9.81 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2 CHRNB3
12 negative regulation of adenylate cyclase activity GO:0007194 9.8 DRD2 GABBR2 OPRM1
13 neuromuscular synaptic transmission GO:0007274 9.8 CHRNA4 CHRNA5 CHRNA6 CHRNB2 CHRNB3
14 membrane depolarization GO:0051899 9.78 CHRNA4 CHRNA6 CHRNB2
15 action potential GO:0001508 9.77 CHRNA4 CHRNB2 CHRNB4
16 dopamine catabolic process GO:0042420 9.73 COMT MAOA SLC6A3
17 acetylcholine receptor signaling pathway GO:0095500 9.73 CHRNA3 CHRNA4 CHRNA7 CHRNB2
18 response to iron ion GO:0010039 9.7 DRD2 SLC6A3
19 smooth muscle contraction GO:0006939 9.69 CHRNB2 CHRNB4
20 regulation of dendrite morphogenesis GO:0048814 9.69 CHRNA3 CHRNB2
21 regulation of smooth muscle contraction GO:0006940 9.69 CHRNA3 CHRNB4
22 positive regulation of long-term synaptic potentiation GO:1900273 9.68 CHRNA7 DRD2
23 dopamine metabolic process GO:0042417 9.68 COMT DRD2
24 prepulse inhibition GO:0060134 9.68 DRD2 SLC6A3
25 neurological system process GO:0050877 9.68 CHRNA4 CHRNB2
26 neurotransmitter catabolic process GO:0042135 9.67 COMT MAOA
27 catecholamine metabolic process GO:0006584 9.67 COMT MAOA
28 regulation of dopamine metabolic process GO:0042053 9.67 CHRNB2 SLC6A3
29 synaptic transmission involved in micturition GO:0060084 9.67 CHRNA3 CHRNB2 CHRNB4
30 adenohypophysis development GO:0021984 9.66 DRD2 SLC6A3
31 short-term memory GO:0007614 9.65 CHRNA7 COMT
32 cation transmembrane transport GO:0098655 9.65 CHRNA6 CHRNB3
33 response to acetylcholine GO:1905144 9.65 CHRNA3 CHRNA7 CHRNB2
34 behavioral response to nicotine GO:0035095 9.65 CHRNA3 CHRNA4 CHRNA5 CHRNB2 CHRNB4
35 B cell activation GO:0042113 9.62 CHRNA4 CHRNB2
36 associative learning GO:0008306 9.61 CHRNB2 DRD2
37 excitatory postsynaptic potential GO:0060079 9.61 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
38 behavioral response to ethanol GO:0048149 9.58 DRD2 OPRM1
39 regulation of synaptic transmission, dopaminergic GO:0032225 9.33 CHRNB2
40 synaptic transmission, cholinergic GO:0007271 9.17 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNB2 CHRNB3
41 signal transduction GO:0007165 10.32 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
42 transport GO:0006810 10.29 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
43 ion transport GO:0006811 10.14 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
44 chemical synaptic transmission GO:0007268 10 CHRNA4 CHRNA5 CHRNA6 GABBR2 OPRM1
45 ion transmembrane transport GO:0034220 10 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2

Molecular functions related to Nicotine Dependence, Protection Against according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 acetylcholine binding GO:0042166 9.92 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
2 extracellular ligand-gated ion channel activity GO:0005230 9.86 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
3 drug binding GO:0008144 9.77 CHRNB2 CHRNB3 CHRNB4 DRD2 SLC6A3
4 ligand-gated ion channel activity GO:0015276 9.76 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
5 ion channel activity GO:0005216 9.71 CHRNA4 CHRNA7 CHRNB2 CHRNB4
6 acetylcholine-gated cation-selective channel activity GO:0022848 9.56 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2
7 dopamine binding GO:0035240 9.43 DRD2 SLC6A3
8 acetylcholine receptor activity GO:0015464 9.17 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNB2

Sources for Nicotine Dependence, Protection Against

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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