MCID: NGH001
MIFTS: 47

Night Blindness malady

Eye category

Summaries for Night Blindness

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Nyctalopia (from Greek νύκτ-, nykt- \"night\"; αλαός, alaos \"blind, not seeing\", and ὄψ,... more...

MalaCards: Night Blindness is related to blindness and congenital stationary night blindness. An important gene associated with Night Blindness is PDE6B (phosphodiesterase 6B, cGMP-specific, rod, beta), and among its related pathways are the visual cycle I (vertebrates) and Retinol metabolism. The drugs cod liver oil and vitamin a and the compounds phosphorhodopsin and gramicidin have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and vision/eye.

Aliases & Classifications for Night Blindness

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

night blindness 8 10 45 61


External Ids:

Disease Ontology8 DOID:8499
ICD9CM27 368.60, 368.6
MeSH35 D009755
ICD1025 H53.6

Related Diseases for Night Blindness

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Night Blindness family:

acquired night blindness

Diseases related to Night Blindness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1blindness31.9RPE65, PDE6B, RHO
2congenital stationary night blindness31.7NYX, GRM6, GRK1, RDH5, PDE6B, CACNA1F
3x-linked congenital stationary night blindness31.1CACNA1F, NYX
4hereditary night blindness30.8CACNA1F, NYX, SAG
5fundus albipunctatus30.5RDH5, CACNA1F
6oguchi disease 130.5CACNA1F, NYX, GRK1, RHO, RDH5, SAG
7cone-rod dystrophy 230.2RHO, RPE65
8leber congenital amaurosis30.2RPE65, PDE6B, RHO
9night blindness, congenital stationary , 2a, x-linked30.2OA2, CACNA1F
10autosomal dominant congenital stationary night blindness10.6
11acquired night blindness10.5
12retinitis pigmentosa10.5
13n syndrome10.4
14xerophthalmia10.4
15congenital stationary night blindness, autosomal dominant 210.4
16congenital stationary night blindness, autosomal dominant 110.4
17night blindness, congenital stationary , 1d, autosomal recessive10.4
18night blindness, congenital stationary , 1e, autosomal recessive10.4
19cystic fibrosis10.3
20congenital stationary night blindness, type 1b10.3
21congenital stationary night blindness, type 2b10.3
22congenital stationary night blindness, type 1c10.3
23night blindness, congenital stationary , 1a, x-linked10.3
24night blindness skeletal anomalies unusual facies10.3
25congenital stationary night blindness, type 1d10.3
26congenital stationary night blindness, type 1e10.3
27congenital stationary night blindness, type 1f10.3
28night blindness - skeletal anomalies - dysmorphism10.3
29gyrate atrophy10.2
30keratomalacia10.2
31primary biliary cirrhosis10.2
32duchenne muscular dystrophy10.2
33congenital nystagmus10.2
34protein c deficiency10.2
35cacna1f-related x-linked congenital stationary night blindness10.2
36nyx-related x-linked congenital stationary night blindness10.2
37night blindness, congenital stationary , 1f, autosomal recessive10.2
38night blindness, congenital stationary , 1b, autosomal recessive10.2
39retinitis pigmentosa 6410.2
40night blindness, congenital stationary , 2b, autosomal recessive10.2
41night blindness, congenital stationary , 1c, autosomal recessive10.2
42hyperopia10.2
43chondroectodermal dysplasia with night blindness10.2
44stargardt disease10.0
45branch retinal artery occlusion10.0
46retinal drusen10.0
47cone-rod dystrophy10.0
48melas syndrome10.0
49refsum disease10.0
50onchocerciasis10.0

Graphical network of the top 20 diseases related to Night Blindness:



Diseases related to night blindness

Clinical Features for Night Blindness

Drugs & Therapeutics for Night Blindness

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Night Blindness

Drug clinical trials:

Search ClinicalTrials for Night Blindness

Search NIH Clinical Center for Night Blindness

Search CenterWatch for Night Blindness

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Night Blindness

Anatomical Context for Night Blindness

Animal Models for Night Blindness or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Night Blindness:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.1GRK1, RHO, PDE6B, SAG, GNAZ, GNAT1
2MP:00053919.7RPE65, GRM6, GRK1, RHO, RDH5, PDE6B

Publications for Night Blindness

Sources:
51PubMed
See all sources

Articles related to Night Blindness:

(show top 50)    (show all 362)
idTitleAuthorsYear
1
A historical perspective on the early treatment of night blindness and the use of dubious and unproven treatment strategies for patients with retinitis pigmentosa. (23911150)
2013
2
Case of acquired night blindness in a hemodialysis patient. (24314428)
2013
3
A child with night blindness: preventing serious symptoms of Refsum disease. (22156782)
2012
4
Docking of human rhodopsin mutant (Gly90a89Asp) with beta-arrestin and cyanidin 3-rutinoside to cure night blindness. (22368384)
2012
5
Night blindness among black troops and white troops in the US Civil War. (23006923)
2012
6
Evaluation of essential trace and toxic elements in biological samples of normal and night blindness children of age groups 3-7 and 8-12 years. (20820941)
2011
7
Evaluation of status of cadmium, lead, and nickel levels in biological samples of normal and night blindness children of age groups 3-7 and 8-12A years. (20703825)
2011
8
Evaluation of status of zinc, copper, and iron levels in biological samples of normal children and children with night blindness with age groups of 3-7 and 8-12A years. (20686870)
2011
9
Fine-mapping and mutation analysis of TRPM1: a candidate gene for leopard complex (LP) spotting and congenital stationary night blindness in horses. (20353955)
2010
10
Night blindness in primary biliary cirrhosis. (20513783)
2010
11
Functional analysis of congenital stationary night blindness type-2 CACNA1F mutations F742C, G1007R, and R1049W. (17949918)
2007
12
Phototransduction in a transgenic mouse model of Nougaret night blindness. (16793893)
2006
13
Congenital stationary night blindness associated with mutations in GRM6 encoding glutamate receptor MGluR6. (16622103)
2006
14
Congenital stationary night blindness type 2 mutations S229P, G369D, L1068P, and W1440X alter channel gating or functional expression of Ca(v)1.4 L-type Ca2+ channels. (15634789)
2005
15
Association between gestational night blindness and serum retinol in mother/newborn pairs in the city of Rio de Janeiro, Brazil. (15811765)
2005
16
Stationary night blindness or progressive retinal degeneration in mice carrying different alleles of PDE gamma. (12700134)
2003
17
ERGs in female carriers of incomplete congenital stationary night blindness (I-CSNB). A family report. (14661912)
2003
18
A novel CACNA1F mutation in a french family with the incomplete type of X-linked congenital stationary night blindness. (12719097)
2003
19
A distinctive form of congenital stationary night blindness with cone ON-pathway dysfunction. (11874764)
2002
20
Abnormalities of the long flash ERG in congenital stationary night blindness of the Schubert-Bornschein type. (12044753)
2002
21
First person. Night blindness. (11695062)
2001
22
Biochemical evidence for pathogenicity of rhodopsin kinase mutations correlated with the oguchi form of congenital stationary night blindness. (9501174)
1998
23
Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect. (9808841)
1998
24
Sustainability of a nutrition education programme to prevent night-blindness in Bangladesh. (8673822)
1996
25
Protein energy malnutrition, vitamin A deficiency and night blindness in Bangladeshi children. (8985529)
1996
26
Spectroscopic evidence for altered chromophore--protein interactions in low-temperature photoproducts of the visual pigment responsible for congenital night blindness. (8942673)
1996
27
Duchenne muscular dystrophy: negative electroretinograms and normal dark adaptation. Reappraisal of assignment of X linked incomplete congenital stationary night blindness. (7616540)
1995
28
Night blindness is prevalent during pregnancy and lactation in rural Nepal. (7643246)
1995
29
X-Linked Congenital Stationary Night Blindness (20301423)
1993
30
Linkage analysis in X-linked congenital stationary night blindness. (1427834)
1992
31
ERG characteristics of congenital stationary night blindness. (2101357)
1990
32
X-linked congenital stationary night blindness. (2785789)
1989
33
Prevention of night-blindness in rural Bangladesh. (2610843)
1989
34
Large rod-like photopic signals in a possible new form of congenital night blindness. (2789128)
1989
35
Night blindness revisited: from man to molecules. Proctor lecture. (6127328)
1982
36
X-linked recessive congenital stationary night blindness, myopia, and tilted discs. (6972443)
1981
37
Resolution of night blindness in fundus albipunctatus. (6975055)
1981
38
Night blindness, characteristic facies, and skeletal abnormalities in two brothers. (314984)
1979
39
Iatrogenic night blindness and keratoconjunctival xerosis. (314593)
1979
40
An electrophysiological and psychophysical study of two forms of congenital night blindness. (4306337)
1969
41
Vitamin A deficiency with xerophthalmia and night blindness in cystic fibrosis. (5303293)
1968
42
Night blindness in the tropics. (14438150)
1960
43
Night blindness and roentgenoscopy. (13238670)
1955
44
Electroretinography in cases of night blindness. (13180620)
1954
45
Congenital stationary night blindness without ophthalmoscopic or other abnormalities. (13102557)
1952
46
Primary chorioretinal aberrations with night blindness; treatment and conclusions. (15443029)
1950
47
Primary chorioretinal aberrations with night blindness; pathology. (15443028)
1950
48
Night-blindness. (20783940)
1941
49
The Incidence of Xerophthalmia and Night-Blindness in the United States-A Gauge of Vitamin A Deficiency. (18013825)
1933
50
Night Blindness: Retinitis Pigmentosa sine Pigmento. (19983250)
1923

Genetic Variations for Night Blindness

Expression for genes affiliated with Night Blindness

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Night Blindness

Search GEO for disease gene expression data for Night Blindness.

Pathways for genes affiliated with Night Blindness

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 52QIAGEN, 30KEGG
See all sources

Compounds for genes affiliated with Night Blindness

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 11DrugBank
See all sources

Compounds related to Night Blindness according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1phosphorhodopsin4510.7SAG, RHO
2gramicidin4510.6SLC24A1, RHO
311-cis-retinol45 2411.6RPE65, RDH5, RHO
4metarhodopsin ii4510.6GRK1, RHO, SAG, GNAZ
5phytate4510.6SAG, GRK1
6cgmp45 2911.6GNAZ, SAG, PDE6B, RHO, GRK1
7(+-)-bay k 86446010.6CACNA1F, OA2
8vitamin a45 11 2412.5GRK1, RHO, RDH5, SAG, RPE65
9nnc 55-0396 dihydrochloride6010.5CACNA1F, OA2
10retinoid4510.5RPE65, SAG, RDH5, RHO
11mibefradil dihydrochloride6010.5CACNA1F, OA2
12omega-conotoxin gvia6010.5CACNA1F, OA2
13pregabalin60 45 1112.4CACNA1F, OA2
14guanylate4510.3GRK1, RHO, SAG
15glutamate4510.3GRM6, GRK1, RHO, SAG, NLRP12
16hydroxylamine4510.1SAG, RHO

GO Terms for genes affiliated with Night Blindness

Sources:
16Gene Ontology
See all sources

Cellular components related to Night Blindness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:09738110.5GRK1, RHO, PDE6B, GNAT1
2photoreceptor inner segmentGO:00191710.4RHO, SAG, GNAT1
3new growing cell tipGO:03584110.4GRM6, TRPM1
4extrinsic to internal side of plasma membraneGO:03123410.4GNAZ, GNAT1
5photoreceptor outer segmentGO:00175010.3RHO, SAG, GNAT1
6photoreceptor outer segment membraneGO:04262210.1RHO, GNAT1

Biological processes related to Night Blindness according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of rhodopsin mediated signaling pathwayGO:02240010.5SAG, PDE6B, RHO, GRK1, GNAT1
2photoreceptor cell morphogenesisGO:00859410.5CABP4, GRK1
3detection of light stimulus involved in visual perceptionGO:05090810.5GNAT1, GRM6, CACNA1F
4rhodopsin mediated signaling pathwayGO:01605610.5GNAT1, SAG, PDE6B, RHO, GRK1, SLC24A1
5retina development in camera-type eyeGO:06004110.4GRM6, RHO, PDE6B, GNAT1, CACNA1F
6response to light intensityGO:00964210.4SLC24A1, GNAT1
7phototransduction, visible lightGO:00760310.4RPE65, GNAT1, SAG, PDE6B, RDH5, RHO
8cellular response to electrical stimulusGO:07125710.4GNAT1, RPE65
9retinoid metabolic processGO:00152310.3RDH5, RPE65, RHO
10visual perceptionGO:00760110.2RDH5, RPE65, CABP4, CACNA1F, GNAT1, SAG
11G-protein coupled glutamate receptor signaling pathwayGO:00721610.1TRPM1, GRM6

Molecular functions related to Night Blindness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein beta/gamma-subunit complex bindingGO:03168310.4GNAZ, GNAT1

Products for genes affiliated with Night Blindness

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Night Blindness

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet