MCID: NGH001
MIFTS: 47

Night Blindness

Categories: Eye diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Night Blindness

MalaCards integrated aliases for Night Blindness:

Name: Night Blindness 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8499
ICD10 33 H53.6 H53.60
ICD9CM 35 368.6 368.60
MeSH 42 D009755
UMLS 69 C0028077

Summaries for Night Blindness

MalaCards based summary : Night Blindness is related to fundus dystrophy and congenital stationary night blindness, and has symptoms including other specified visual disturbances, photophobia and amaurosis fugax. An important gene associated with Night Blindness is PDE6B (Phosphodiesterase 6B), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and Phototransduction. The drugs Epinephrine and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and nervous system

Wikipedia : 72 Nyctalopia /ˌnɪktəlˈoʊpiə/ (from Greek νύκτ-, nykt- \"night\"; ἀλαός, alaos \"blind, not seeing\", and... more...

Related Diseases for Night Blindness

Diseases in the Night Blindness family:

Acquired Night Blindness Hereditary Night Blindness

Diseases related to Night Blindness via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 fundus dystrophy 22.2 CABP4 CACNA1F GNAT1 GNB3 GPR179 GRK1
2 congenital stationary night blindness 12.5
3 hereditary night blindness 12.5
4 x-linked congenital stationary night blindness 12.5
5 night blindness, congenital stationary , 1b, autosomal recessive 12.4
6 night blindness, congenital stationary , 1a, x-linked 12.4
7 night blindness, congenital stationary, autosomal dominant 3 12.3
8 night blindness, congenital stationary, autosomal dominant 2 12.3
9 night blindness, congenital stationary , 1d, autosomal recessive 12.3
10 autosomal recessive congenital stationary night blindness 12.3
11 night blindness, congenital stationary , 1f, autosomal recessive 12.3
12 night blindness, congenital stationary, autosomal dominant 1 12.3
13 night blindness, congenital stationary , 1e, autosomal recessive 12.3
14 night blindness, congenital stationary, type 1h 12.3
15 autosomal dominant congenital stationary night blindness 12.3
16 night blindness, congenital stationary , 1c, autosomal recessive 12.3
17 night blindness, congenital stationary , 2a, x-linked 12.3
18 night blindness, congenital stationary, type 1g 12.3
19 acquired night blindness 12.1
20 congenital stationary night blindness, type 2b 12.0
21 night blindness skeletal anomalies unusual facies 11.9
22 cacna1f-related x-linked congenital stationary night blindness 11.9
23 nyx-related x-linked congenital stationary night blindness 11.9
24 night blindness-skeletal anomalies-dysmorphism syndrome 11.9
25 chondroectodermal dysplasia with night blindness 11.9
26 oguchi disease-1 11.7
27 oguchi disease-2 11.7
28 retinal cone dystrophy 3 11.6
29 cone-rod synaptic disorder, congenital nonprogressive 11.6
30 retinal cone dystrophy 3b 11.5
31 fundus albipunctatus 11.3
32 choroideremia 11.3
33 retinitis pigmentosa 11.3
34 keratomalacia 11.3
35 refsum disease 11.0
36 melanoma-associated retinopathy 11.0
37 retinal degeneration, late-onset, autosomal dominant 10.9
38 bietti crystalline corneoretinal dystrophy 10.9
39 cone-rod dystrophy 16 10.9
40 gyrate atrophy of choroid and retina with or without ornithinemia 10.9
41 enhanced s-cone syndrome 10.9
42 leber congenital amaurosis 2 10.7
43 leber congenital amaurosis 8 10.7
44 ataxia, posterior column, with retinitis pigmentosa 10.7
45 retinitis pigmentosa 67 10.7
46 jalili syndrome 10.7
47 wagner syndrome 1 10.7
48 retinitis pigmentosa 9 10.7
49 retinal dystrophy and obesity 10.7
50 microphthalmia, isolated 5 10.7

Graphical network of the top 20 diseases related to Night Blindness:



Diseases related to Night Blindness

Symptoms & Phenotypes for Night Blindness

UMLS symptoms related to Night Blindness:


other specified visual disturbances, photophobia, amaurosis fugax, subjective visual disturbance, unspecified, metamorphopsia, blurred vision, visual disturbance, visual manifestations

GenomeRNAi Phenotypes related to Night Blindness according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.58 CABP4
2 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.58 RDH5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.58 CABP4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.58 CABP4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.58 CABP4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.58 TRPM1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.58 RDH5
8 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.58 CABP4 RDH5 TRPM1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.58 CABP4
10 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.58 CABP4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.58 TRPM1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.58 RDH5 TRPM1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.58 TRPM1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.58 TRPM1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.58 CABP4

MGI Mouse Phenotypes related to Night Blindness:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.7 CABP4 CACNA1F GNAT1 GNB3 GRK1 GRM6
2 vision/eye MP:0005391 9.5 GNB3 GPR179 GRK1 GRM6 LRIT3 NYX

Drugs & Therapeutics for Night Blindness

Drugs for Night Blindness (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Racepinephrine Approved Phase 4
5
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
6
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 11103-57-4, 68-26-8 445354
7 Antioxidants Phase 4,Phase 3,Phase 2,Early Phase 1
8 Micronutrients Phase 4,Phase 3,Phase 2,Early Phase 1
9 Protective Agents Phase 4,Phase 3,Phase 2,Early Phase 1
10 Retinol palmitate Phase 4,Phase 3,Phase 2,Early Phase 1
11 Trace Elements Phase 4,Phase 3,Phase 2,Early Phase 1
12 Vitamins Phase 4,Phase 3,Phase 2,Early Phase 1
13 Antiemetics Phase 4,Phase 2
14 Anti-Inflammatory Agents Phase 4,Phase 2
15 Antineoplastic Agents, Hormonal Phase 4,Phase 2
16 Autonomic Agents Phase 4,Phase 2
17 Epinephryl borate Phase 4
18 Gastrointestinal Agents Phase 4,Phase 2
19 glucocorticoids Phase 4,Phase 2
20 Hormone Antagonists Phase 4,Phase 2
21 Hormones Phase 4,Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
23 Methylprednisolone acetate Phase 4
24 Methylprednisolone Hemisuccinate Phase 4
25 Neuroprotective Agents Phase 4
26 Peripheral Nervous System Agents Phase 4,Phase 2
27 Prednisolone acetate Phase 4
28 Prednisolone hemisuccinate Phase 4
29 Prednisolone phosphate Phase 4
30 Anthelmintics Phase 4
31 Anti-Infective Agents Phase 4
32 Antimitotic Agents Phase 4
33 Antiparasitic Agents Phase 4
34 Antiprotozoal Agents Phase 4
35 retinol Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1
36
Iron Approved Phase 2, Phase 3, Early Phase 1 7439-89-6 23925
37 Orange Approved, Nutraceutical Phase 3
38
B-Carotene Approved, Nutraceutical Phase 3,Phase 2 7235-40-7 5280489
39 Tocopherol Approved, Nutraceutical Phase 2, Phase 3
40
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-02-9 14985
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
42
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
43 Vaccines Phase 2, Phase 3
44 Carotenoids Phase 3,Phase 2
45 Tin Fluorides Phase 2, Phase 3
46 Tocopherols Phase 2, Phase 3
47 Tocotrienols Phase 2, Phase 3
48 Ferrous fumarate Phase 3
49 Hematinics Phase 3
50 Vitamin B Complex Phase 3

Interventional clinical trials:

(show top 50) (show all 65)

id Name Status NCT ID Phase Drugs
1 Adrenal Cortical Function and Vitamin A Deficiency in Sepsis Completed NCT03152474 Phase 4 Solumedrol 20mg;Vitamin A 100,000 IU
2 Deworming and Enhanced Vitamin A Every 6 Month in Rural Indian Children Aged 1-6 Completed NCT00222547 Phase 4 Vitamin A;Albendazole
3 Efficacy of β-carotene Biofortified Maize in Reducing Vitamin A Deficiency Among Children Completed NCT01695148 Phase 3
4 Efficacy of Biofortified Maize to Improve Maternal and Infant Vitamin A Status Completed NCT02804490 Phase 3
5 Stopping Postpartum Vitamin A Supplementation: Missing Concealed Benefit Completed NCT02043223 Phase 2, Phase 3
6 Impact of Maternal Supplementation With Dual Megadose of Vitamin A Completed NCT00742937 Phase 2, Phase 3
7 Trial of the Impact of Vitamin A on Maternal Mortality Completed NCT00211341 Phase 3
8 Impact of Maternal Vitamin A or Beta-Carotene Supplementation on Maternal and Infant Mortality in Bangladesh Completed NCT00198822 Phase 3
9 Sub-clinical Inflammation and Iron Supplementation Completed NCT01198574 Phase 3
10 Carotenoid Supplementation and Normal Ocular Health Completed NCT02147171 Phase 2, Phase 3
11 Community Trial of Newborn Vitamin A Supplementation to Reduce Infant Mortality in Rural Bangladesh Terminated NCT00128557 Phase 3 vitamin A supplementation (50,000 IU)
12 Effect of Vitamin A Supplementation on Immune Responses in Human Neonates Unknown status NCT01476358 Phase 2
13 Vitamin A Absorption From Cassava in Women Completed NCT01381276 Phase 2
14 Vitamin A Equivalence of Plant Carotenoids in Children Completed NCT00680212 Phase 2
15 Vitamin A to Reduce HIV in Vaginal Secretions and Prevent Viral Transmission Completed NCT00053612 Phase 2 Vitamin A
16 Single-dose Postpartum Vitamin A Supplementation of Mothers and Neonates Active, not recruiting NCT00198718 Phase 2 Vitamin A (retinyl palmitate)
17 Intravitreal Dexamethasone Implant in Retinitis Pigmentosa-related Macular Edema- a Retrospective Study Enrolling by invitation NCT02804360 Phase 2
18 Gene Therapy for Gyrate Atrophy Completed NCT00001735 Phase 1
19 Evaluation of Safety of Ciliary Neurotrophic Factor Implants in the Eye Completed NCT00063765 Phase 1 Ciliary Neurotrophic Factor Implant NT-501
20 Using Stable Isotope Techniques to Monitor and Assess the Vitamin A Status of Children Susceptible to Infection Unknown status NCT02363985
21 Vitamin A Supplementation in Preterm Infants Unknown status NCT00063596 Vitamin A supplementation
22 Nutributter Programming to Prevent Undernutrition: an Evaluation Unknown status NCT01552512
23 Treatment of Congenital Stationary Night Blindness With an Alga Containing High Dose of Beta Carotene Completed NCT00569023
24 Efficacy of Vitamin A in Fortified Extruded Rice in School Children Completed NCT01199445 Early Phase 1
25 Efficacy of Newborn Vitamin A Supplementation in Improving Immune Function Completed NCT01583972
26 Newborn Vitamin A (VA) Supplementation Pilot Project, Pakistan Completed NCT00674089
27 Dietary Vitamin A Requirement in Chinese Children and the New Technology of Dietary Assessment Completed NCT01559766
28 An Efficacy Trial of Iron, Zinc and Vitamin A Fortified Rice in Children in Satun, Thailand Completed NCT01061307 Early Phase 1
29 Vitamin A, Stool Microbiota and Vaccine Response in Bangladeshi Infants Completed NCT02027610
30 Retinol Equivalence of Plant Carotenoids in Children Completed NCT00082420
31 Evaluation of a Night Spectacle Correction Concerning an Improvement of Mesopic Vision Quality Completed NCT02965534
32 Vitamin A Liver Reserves and Serum Markers of Vitamin A in US Adults at Time of Death Completed NCT03305042
33 Efficacy of Yellow Cassava to Improve Vitamin A Status of Kenyan School Children Completed NCT01614483
34 The Efficacy of Pro-vitamin A Biofortified Cassava on Vitamin A Status in Nigerian Preschool Children Completed NCT02627222
35 Visual Activity Evoked by Infrared in Humans After Dark Adaptation Completed NCT02909985
36 Vitamin A Equivalence of the Provitamin A in Biofortified Bananas Completed NCT02702622
37 Beta-carotene Absorption and Bioconversion to Vitamin A From Biofortified Cassava Gari Completed NCT02210507
38 Effect of Daily Consumption of Orange Maize on Breast Milk Retinol in Lactating Zambian Women Completed NCT01922713
39 Vitamin A Bioavailability in Lactating Women With Marginal Vitamin A Status Completed NCT01420406
40 Impact of Consumption of Orange-fleshed Sweet Potatoes on the Vitamin A Status of Bangladeshi Women of Reproductive Age Completed NCT00453648
41 Effect of SNPs in the BCMO1 Enzyme Completed NCT02276014
42 Assessing Model Parameters for Applying the Retinol Isotope Dilution (RID) Method Completed NCT02996513
43 A Study on Immunological Effect of Vitamin A and Zinc in a Placebo Controlled 4 Cell Trial Completed NCT00374023 Zinc, or Vitamin A or both
44 Making Maternal Post-partum Vitamin A Supplementation Effective: The Role of Timing and Inflammation Completed NCT00952640
45 Vitamin A and Maternal-infant Flu Vaccine Response Completed NCT00817661
46 Oral Vitamin A Supplementation in Neonates With Birth Weight < 1500 g Completed NCT02102711
47 High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM Completed NCT00388921 Vitamin A
48 Newly Formulated, Extruded Fortified-blended Foods for Food Aid: the MFFAPP Tanzania Efficacy Study Completed NCT02847962
49 A Randomized Controlled Trial Testing The Effect Of A Multi-Nutrient Fortified Juice Completed NCT01909063
50 Blueberry Effects on Dark Vision and Glare Recovery Completed NCT01942746

Search NIH Clinical Center for Night Blindness

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: night blindness

Genetic Tests for Night Blindness

Anatomical Context for Night Blindness

MalaCards organs/tissues related to Night Blindness:

39
Eye, Liver, Testes, Breast, Bone, Retina, Pancreas

Publications for Night Blindness

Articles related to Night Blindness:

(show top 50) (show all 399)
id Title Authors Year
1
Long-Term Clinical Course in a Patient with Complete Congenital Stationary Night Blindness. ( 28512427 )
2017
2
Structural role of the T94I rhodopsin mutation in congenital stationary night blindness. ( 27458239 )
2016
3
Next-generation sequencing confirms the implication of SLC24A1 in autosomal-recessive congenital stationary night blindness. ( 26822852 )
2016
4
Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin Mutation. ( 26427453 )
2016
5
Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics. ( 27267879 )
2016
6
Psychophysical measures of visual function and everyday perceptual experience in a case of congenital stationary night blindness. ( 27601873 )
2016
7
Biallelic Mutations in GNB3 Cause a Unique Form of Autosomal-Recessive Congenital Stationary Night Blindness. ( 27063057 )
2016
8
Redundant contribution of a Transient Receptor Potential cation channel Member 1 exon 11 single nucleotide polymorphism to equine congenital stationary night blindness. ( 27329127 )
2016
9
Mutation screening of the LRIT3, CABP4, and GPR179 genes in Chinese patients with Schubert-Bornschein congenital stationary night blindness. ( 27428514 )
2016
10
Congenital stationary night blindness with hypoplastic discs, negative electroretinogram and thinning of the inner nuclear layer. ( 27084085 )
2016
11
Clinical Characteristics, Mutation Spectrum, and Prevalence of A8land Eye Disease/Incomplete Congenital Stationary Night Blindness in Denmark. ( 28002560 )
2016
12
Novel TRPM1 mutations in two Chinese families with early-onset high myopia, with or without complete congenital stationary night blindness. ( 27803854 )
2016
13
Cacna1f gene decreased contractility of skeletal muscle in rat model with congenital stationary night blindness. ( 25748727 )
2015
14
Determinants of gestational night blindness in pregnant women from Rio de Janeiro, Brazil. ( 26055085 )
2015
15
Assessment of selenium and mercury in biological samples of normal and night blindness children of age groups (3-7) and (8-12) years. ( 25655123 )
2015
16
A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness. ( 26368928 )
2015
17
Mutations in GRM6 identified in consanguineous Pakistani families with congenital stationary night blindness. ( 26628857 )
2015
18
Identification of a new mutant allele, Grm6(nob7), for complete congenital stationary night blindness. ( 26241901 )
2015
19
Two Novel NYX Gene Mutations in the Chinese Families with X-linked Congenital Stationary Night Blindness. ( 26234941 )
2015
20
Recurrent episodes of night blindness in a patient with short bowel syndrome. ( 26507840 )
2015
21
Acquired night blindness due to bad eating patterns. ( 25804276 )
2015
22
Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness. ( 26310623 )
2015
23
A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. ( 26246500 )
2015
24
Night blindness due to vitamin A deficiency associated with resected adenocarcinoma of the pancreas. ( 25709934 )
2015
25
Twenty-five thousand years of fluctuating selection on leopard complex spotting and congenital night blindness in horses. ( 25487337 )
2015
26
Isotretinoin-Induced Night Blindness. ( 26288455 )
2015
27
Photoreceptor degeneration in two mouse models for congenital stationary night blindness type 2. ( 24466230 )
2014
28
The role of prenatal nutrition assistance on the prevalence of night blindness in pregnant adults. ( 24951995 )
2014
29
Molecular profiling of complete congenital stationary night blindness: a pilot study on an Indian cohort. ( 24715752 )
2014
30
Night blindness due to vitamin A deficiency associated with copper deficiency myelopathy secondary to bowel bypass surgery. ( 24781845 )
2014
31
A truncated form of rod photoreceptor PDE6 I^-subunit causes autosomal dominant congenital stationary night blindness by interfering with the inhibitory activity of the I^-subunit. ( 24760071 )
2014
32
Prevalence of night blindness in Bashagard district in Hormozgan, Iran, in 2011. ( 25763164 )
2014
33
Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2. ( 24796500 )
2014
34
Night blindness and Crohn's disease. ( 24715231 )
2014
35
Night blindness and ancient remedy. ( 25774260 )
2014
36
Isotretinoin and night blindness. ( 25117163 )
2014
37
Congenital stationary night blindness: An analysis and update of genotype-phenotype correlations and pathogenic mechanisms. ( 25307992 )
2014
38
Lrit3 deficient mouse (nob6): a novel model of complete congenital stationary night blindness (cCSNB). ( 24598786 )
2014
39
Sorting out Co-occurrence of Rare Monogenic Retinopathies: Stargardt Disease Co-existing with Congenital Stationary Night Blindness. ( 24397708 )
2014
40
Seasonal variation in night blindness incidence among Union soldiers in the US Civil War. ( 25200714 )
2014
41
Genotype and phenotype of 101 dutch patients with congenital stationary night blindness. ( 23714322 )
2013
42
A historical perspective on the early treatment of night blindness and the use of dubious and unproven treatment strategies for patients with retinitis pigmentosa. ( 23911150 )
2013
43
Case of acquired night blindness in a hemodialysis patient. ( 24314428 )
2013
44
Assessment of night vision problems in patients with congenital stationary night blindness. ( 23658786 )
2013
45
Whole-exome sequencing identifies LRIT3 mutations as a cause of autosomal-recessive complete congenital stationary night blindness. ( 23246293 )
2013
46
Insights into congenital stationary night blindness based on the structure of G90D rhodopsin. ( 23579341 )
2013
47
Electroretinographic findings in a patient with congenital stationary night blindness due to a novel NYX mutation. ( 23289809 )
2013
48
Dysregulation of Cav 1.4 channels disrupts the maturation of photoreceptor synaptic ribbons in congenital stationary night blindness type 2. ( 24064553 )
2013
49
Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding. ( 23872075 )
2013
50
Evidence for a retroviral insertion in TRPM1 as the cause of congenital stationary night blindness and leopard complex spotting in the horse. ( 24167615 )
2013

Variations for Night Blindness

Copy number variations for Night Blindness from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 175785 3 44200000 50600000 Gain or loss GNAT1 Night blindness

Expression for Night Blindness

Search GEO for disease gene expression data for Night Blindness.

Pathways for Night Blindness

GO Terms for Night Blindness

Cellular components related to Night Blindness according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 photoreceptor inner segment GO:0001917 9.43 GNAT1 RHO SAG
2 photoreceptor outer segment membrane GO:0042622 9.32 GNAT1 RHO
3 photoreceptor outer segment GO:0001750 9.26 CACNA1F GNAT1 RHO SAG
4 new growing cell tip GO:0035841 9.16 GRM6 TRPM1
5 photoreceptor disc membrane GO:0097381 8.92 GNAT1 GRK1 PDE6B RHO

Biological processes related to Night Blindness according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.8 CABP4 CACNA1F GNAT1 GPR179 GRK1 GRM6
2 calcium ion transmembrane transport GO:0070588 9.72 CACNA1F SLC24A1 TRPM1
3 retina development in camera-type eye GO:0060041 9.67 GNAT1 GRM6 PDE6B RHO
4 regulation of rhodopsin mediated signaling pathway GO:0022400 9.65 GNAT1 GRK1 PDE6B RHO SAG
5 phototransduction GO:0007602 9.63 CABP4 GNAT1 RHO
6 detection of light stimulus involved in visual perception GO:0050908 9.58 CACNA1F GNAT1 GRM6
7 response to light stimulus GO:0009416 9.56 GNAT1 RHO
8 rhodopsin mediated signaling pathway GO:0016056 9.55 GNAT1 GRK1 PDE6B RHO SAG
9 sensory perception of light stimulus GO:0050953 9.54 GRM6 RHO
10 G-protein coupled glutamate receptor signaling pathway GO:0007216 9.52 GRM6 TRPM1
11 response to light intensity GO:0009642 9.51 GNAT1 SLC24A1
12 phototransduction, visible light GO:0007603 9.5 GNAT1 PDE6B RHO
13 cellular response to light stimulus GO:0071482 9.49 RHO TRPM1
14 detection of light stimulus GO:0009583 9.48 PDE6B RHO
15 response to stimulus GO:0050896 9.4 CACNA1F GNAT1 GRK1 GRM6 LRIT3 NYX
16 signal transduction GO:0007165 10.09 CABP4 GNAT1 GNB3 GRK1 GRM6 PDE6B

Molecular functions related to Night Blindness according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.26 GNAT1 GNB3 GRM6 RHO
2 calcium channel activity GO:0005262 8.8 CACNA1F SLC24A1 TRPM1

Sources for Night Blindness

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....