MCID: NJM001
MIFTS: 69

Nijmegen Breakage Syndrome malady

Categories: Genetic diseases, Rare diseases, Fetal diseases, Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Nijmegen Breakage Syndrome

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Aliases & Descriptions for Nijmegen Breakage Syndrome:

Name: Nijmegen Breakage Syndrome 49 10 11 21 45 22 23 47 12 51 67 36 65
Berlin Breakage Syndrome 10 21 45 22 23 51
Ataxia-Telangiectasia Variant 1 21 22 23
Nbs 51 67 2
Immunodeficiency, Microcephaly with Normal Intelligence 45 24
Microcephaly, Normal Intelligence and Immunodeficiency 10 23
Seemanova Syndrome 10 23
Microcephaly with Normal Intelligence Immunodeficiency and Lymphoreticular Malignancies 45
Nonsyndromal Microcephaly Autosomal Recessive with Normal Intelligence 45
 
Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome 51
Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome 51
Microcephaly Immunodeficiency Lymphoreticuloma 45
Ataxia-Telangiectasia Variant V1 45
Ataxia-Telangiectasia, Variant 1 51
Seemanova Syndrome Type 2 51
Seemanova Syndrome 2 45
at V1 51
at-V1 22

Characteristics:

Orphanet epidemiological data:

51
nijmegen breakage syndrome:
Inheritance: Autosomal recessive; Age of onset: Infancy,Neonatal

HPO:

61
nijmegen breakage syndrome:
Inheritance: autosomal recessive inheritance


Classifications:



External Ids:

OMIM49 251260
Disease Ontology10 DOID:7400
MeSH36 D049932
NCIt42 C4692
SNOMED-CT59 234638009
Orphanet51 647
MESH via Orphanet37 C531759, D049932
UMLS via Orphanet66 C0398791, C2930831
UMLS65 C0398791

Summaries for Nijmegen Breakage Syndrome

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OMIM:49 The Nijmegen breakage syndrome and the phenotypically indistinguishable Berlin breakage syndrome are autosomal... (251260) more...

MalaCards based summary: Nijmegen Breakage Syndrome, also known as berlin breakage syndrome, is related to breast cancer and nijmegen breakage syndrome-like disorder, and has symptoms including urogenital fistula, cognitive impairment and abnormal hair quantity. An important gene associated with Nijmegen Breakage Syndrome is NBN (Nibrin), and among its related pathways are miRNA Regulation of DNA Damage Response and Telomere Extension by Telomerase. Affiliated tissues include breast, kidney and lung, and related mouse phenotypes are pigmentation and adipose tissue.

UniProtKB/Swiss-Prot:67 Nijmegen breakage syndrome: A disorder characterized by chromosomal instability, radiation sensitivity, microcephaly, growth retardation, immunodeficiency and predisposition to cancer, particularly to lymphoid malignancies.

Genetics Home Reference:23 Nijmegen breakage syndrome is a condition characterized by short stature, an unusually small head size (microcephaly), distinctive facial features, recurrent respiratory tract infections, an increased risk of cancer, intellectual disability, and other health problems.

Wikipedia:68 Nijmegen breakage syndrome (NBS), also known as Berlin breakage syndrome, ataxia telangiectasia variant... more...

GeneReviews summary for NBK1176

Related Diseases for Nijmegen Breakage Syndrome

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Diseases in the Nijmegen Breakage Syndrome family:

Nijmegen Breakage Syndrome-Like Disorder

Diseases related to Nijmegen Breakage Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer27.7ATM, ATR, BRCA1, CHEK2, MRE11A, NBN
2nijmegen breakage syndrome-like disorder12.6
3neuroblastoma11.6
4nicolaides-baraitser syndrome11.1
5ataxia10.6
6ataxia-telangiectasia10.6
7cerebellar hypoplasia10.5ATM, MRE11A
8acute pancreatitis10.4NBN, TP53
9leukemia10.4
10lymphoma10.4
11pancreatic cancer 410.4BRCA1, NBN
12liddle syndrome, scnn1b-related10.3CHEK2, TP53
13charcot-marie-tooth disease, type 4b110.3MRE11A, NBN, RAD50
14lymphoblastic leukemia10.3
15microcephaly10.3
16pancreatic serous cystadenocarcinoma10.3BRCA1, TP53
17cystadenoma10.3BRCA1, TP53
18exposure keratitis10.3BRCA1, TP53
19endometrial mucinous adenocarcinoma10.3BRCA1, TP53
20medulloblastoma10.2
21non-amyloid monoclonal immunoglobulin deposition disease10.2ATM, CHEK2
22peritoneal cystic mesothelioma10.2BRCA1, TP53
23pyosalpinx10.2BRCA1, TP53
24smoking as a quantitative trait locus 110.1ATM, NBN, TP53
25dermato-cardio-skeletal syndrome, borrone type10.1H2AFX, TP53
26fallopian tube leiomyosarcoma10.1BRCA1, TP53
27prostate cancer10.1
28hodgkin lymphoma10.1
29prostatitis10.1
30alzheimer disease 1210.1MRE11A, NBN, WRN
31lymphatic system cancer10.1BRCA1, TP53
32qazi markouizos syndrome10.1NBN, TP53, WRN
33uterine carcinosarcoma10.1BRCA1, TP53
34mutiple parosteal osteochondromatous proliferations10.0BRCA1, TP53
35internal auditory canal lipoma10.0ATM, BRCA1, TP53
36common bile duct disease10.0ATM, BRCA1, TP53
37rheumatoid arthritis10.0
38hiv-110.0
39schizencephaly10.0
40hepatocellular carcinoma10.0
41aplastic anemia10.0
42insulin-like growth factor i10.0
43acute monocytic leukemia10.0
44arthritis10.0
45b-cell lymphomas10.0
46cholangiocarcinoma10.0
47prolymphocytic leukemia10.0
48rhabdomyosarcoma10.0
49porokeratosis10.0
50thrombophlebitis10.0

Graphical network of the top 20 diseases related to Nijmegen Breakage Syndrome:



Diseases related to nijmegen breakage syndrome

Symptoms for Nijmegen Breakage Syndrome

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Symptoms by clinical synopsis from OMIM:

251260

Clinical features from OMIM:

251260

Symptoms:

 51 (show all 44)
  • microcephaly
  • sloping forehead
  • low hair line-front
  • face/facial anomalies
  • upslanted palpebral fissures/mongoloid slanting palpebral fissures
  • micrognathia/retrognathia/micrognathism/retrognathism
  • long/large/bulbous nose
  • beaked nose
  • depressed nasal bridge
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • philtrum deeply grooved
  • anomalies of ear and hearing
  • short neck
  • hair and scalp anomalies
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • anus/rectum anomalies
  • imperforate anus/rectum atresia/agenesis/recto-vaginal/vesical/perineal fistula
  • malabsorption/chronic diarrhea/steatorrhea
  • repeat respiratory infections
  • megaureter/hydronephrosis/pyeloureteral junction syndrome
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • hyperactivity/attention deficit
  • monoclonal immunoglobulins/gammapathy/dysglobulinemia
  • hemolytic anemia
  • thrombocytopenia/thrombopenia
  • autosomal recessive inheritance
  • chromosome breakage
  • wasted (excluding lipodystrophy)/poorly muscled build/cachexy
  • short stature/dwarfism/nanism
  • thymic aplasia/hypoplasia
  • neoplasms/tumors
  • lateral cleft lip/gingival cleft/paramedian nasal cleft
  • cleft palate without cleft lip/submucosal cleft palate/bifid uvula
  • skin photosensitivity
  • excessive freckling
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • agyria/micro/pachy/macrogyria/lissencephaly/gyration/neuronal migration defect
  • muscle anomalies
  • muscle weakness/flaccidity
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • glial tumor/glioblastoma
  • medulloblastoma
  • lymphoma
  • acute leukemia

HPO human phenotypes related to Nijmegen Breakage Syndrome:

(show all 77)
id Description Frequency HPO Source Accession
1 urogenital fistula hallmark (90%) HP:0100589
2 cognitive impairment hallmark (90%) HP:0100543
3 abnormal hair quantity hallmark (90%) HP:0011362
4 abnormality of the upper urinary tract hallmark (90%) HP:0010935
5 abnormal immunoglobulin level hallmark (90%) HP:0010701
6 attention deficit hyperactivity disorder hallmark (90%) HP:0007018
7 depressed nasal bridge hallmark (90%) HP:0005280
8 abnormal nasal morphology hallmark (90%) HP:0005105
9 decreased body weight hallmark (90%) HP:0004325
10 short stature hallmark (90%) HP:0004322
11 abnormality of chromosome stability hallmark (90%) HP:0003220
12 recurrent respiratory infections hallmark (90%) HP:0002205
13 malabsorption hallmark (90%) HP:0002024
14 deep philtrum hallmark (90%) HP:0002002
15 hemolytic anemia hallmark (90%) HP:0001878
16 thrombocytopenia hallmark (90%) HP:0001873
17 upslanted palpebral fissure hallmark (90%) HP:0000582
18 short neck hallmark (90%) HP:0000470
19 convex nasal ridge hallmark (90%) HP:0000444
20 hearing abnormality hallmark (90%) HP:0000364
21 micrognathia hallmark (90%) HP:0000347
22 sloping forehead hallmark (90%) HP:0000340
23 low anterior hairline hallmark (90%) HP:0000294
24 microcephaly hallmark (90%) HP:0000252
25 sinusitis hallmark (90%) HP:0000246
26 aplasia/hypoplasia of the thymus typical (50%) HP:0010515
27 non-midline cleft lip occasional (7.5%) HP:0100335
28 glioma occasional (7.5%) HP:0009733
29 skeletal muscle atrophy occasional (7.5%) HP:0003202
30 medulloblastoma occasional (7.5%) HP:0002885
31 lymphoma occasional (7.5%) HP:0002665
32 acute leukemia occasional (7.5%) HP:0002488
33 abnormality of neuronal migration occasional (7.5%) HP:0002269
34 respiratory insufficiency occasional (7.5%) HP:0002093
35 freckling occasional (7.5%) HP:0001480
36 muscle weakness occasional (7.5%) HP:0001324
37 cutaneous photosensitivity occasional (7.5%) HP:0000992
38 cleft palate occasional (7.5%) HP:0000175
39 b lymphocytopenia HP:0010976
40 malar prominence HP:0010620
41 glioma HP:0009733
42 recurrent pneumonia HP:0006532
43 progressive vitiligo HP:0005602
44 t lymphocytopenia HP:0005403
45 recurrent infection of the gastrointestinal tract HP:0004798
46 short stature HP:0004322
47 long nose HP:0003189
48 dysgammaglobulinemia HP:0002961
49 medulloblastoma HP:0002885
50 rhabdomyosarcoma HP:0002859
51 recurrent bronchitis HP:0002837
52 lymphoma HP:0002665
53 neurodegeneration HP:0002180
54 bronchiectasis HP:0002110
55 anal stenosis HP:0002025
56 anal atresia HP:0002023
57 diarrhea HP:0002014
58 autoimmune hemolytic anemia HP:0001890
59 thrombocytopenia HP:0001873
60 primary ovarian failure HP:0001587
61 intrauterine growth retardation HP:0001511
62 intellectual disability HP:0001249
63 cafe-au-lait spot HP:0000957
64 hyperactivity HP:0000752
65 upslanted palpebral fissure HP:0000582
66 choanal atresia HP:0000453
67 macrotia HP:0000400
68 otitis media HP:0000388
69 micrognathia HP:0000347
70 sloping forehead HP:0000340
71 mastoiditis HP:0000265
72 microcephaly HP:0000252
73 sinusitis HP:0000246
74 cleft upper lip HP:0000204
75 cleft palate HP:0000175
76 hydronephrosis HP:0000126
77 recurrent urinary tract infections HP:0000010

Drugs & Therapeutics for Nijmegen Breakage Syndrome

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Drugs for Nijmegen Breakage Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 58)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Dexamethasoneapproved, investigationalPhase 4190950-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Baycadron
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
Dexameth
Dexamethansone
 
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone acetate
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone sodium phosphate
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamethsone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
Ozurdex
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
2
RanibizumabapprovedPhase 4460347396-82-1459903
Synonyms:
347396-82-1
D05697
Lucentis
Lucentis (TN)
 
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination)
Ranibizumab (genetical recombination) (JAN)
ranibizumab
rhuFab V2
3Immunologic FactorsPhase 4, Phase 218483
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 49988
5Hormone AntagonistsPhase 410002
6Pharmaceutical SolutionsPhase 4, Phase 37004
7Angiogenesis InhibitorsPhase 43688
8Protease InhibitorsPhase 44558
9HIV Protease InhibitorsPhase 44558
10Peripheral Nervous System AgentsPhase 4, Phase 318510
11HormonesPhase 411748
12BB 1101Phase 41909
13Antineoplastic Agents, HormonalPhase 4, Phase 34256
14Anti-Inflammatory AgentsPhase 48478
15Angiogenesis Modulating AgentsPhase 43611
16Dexamethasone 21-phosphatePhase 41909
17AntiemeticsPhase 43213
18Dexamethasone acetatePhase 419091177-87-3
19Gastrointestinal AgentsPhase 4, Phase 36401
20glucocorticoidsPhase 43896
21histidineNutraceuticalPhase 436
22
Carbamazepineapproved, investigationalPhase 3118298-46-42554
Synonyms:
2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene-2-carboxamide
298-46-4
5-Carbamoyl-5H-dibenz(b,f)azepine
5-Carbamoyl-5H-dibenz[b,F]azepine
5-Carbamoyl-5H-dibenz[b,f]azepine
5-Carbamoyl-5H-dibenzo(b,F)azepine
5-Carbamoyl-5H-dibenzo(b,f)azepine
5-Carbamoyldibenzo(b,f)azepine
5-Carbamyl-5H-dibenzo(b,F)azepine
5-Carbamyl-5H-dibenzo(b,f)azepine
5-Carbamyldibenzo(b,f)azepine
5H-Dibenz(b,F)azepine-5-carboxamide
5H-Dibenz(b,f)azepine-5-carboxamide
5H-Dibenz[b,f]azepine-5- carboxamide
5H-Dibenz[b,f]azepine-5-carboxamide
5H-Dibenzo[b,f]azepine-5-carboxamide
85756-57-6 (di-hydrate)
AC-10560
AC1L1DXT
AC1Q4ZSU
AC1Q4ZSV
AKOS003235644
Amizepin
Amizepine
Apo-Carbamazepine
Atretol
BIDD:GT0479
BIM-0050280.0001
BPBio1_000225
BRD-K71799949-001-06-7
BRN 1246090
BSPBio_000203
BSPBio_001929
Bio-0751
Bipotrol
Biston
C 4024
C06868
C4024_SIAL
C4024_SIGMA
C8981_SIAL
CARBAMAZEPINE, U.S.P.
CAS-298-46-4
CBChromo1_000350
CBZ
CDS1_002710
CHEBI:3387
CHEMBL108
CID2554
CPD001227191
Calepsin
Carbamazepan
Carbamazepen
Carbamazepin
Carbamazepina
Carbamazepina [INN-Spanish]
Carbamazepine
Carbamazepine (JP15/USP/INN)
Carbamazepine ER
Carbamazepine [USAN:INN:BAN:JAN]
Carbamazepinum
Carbamazepinum [INN-Latin]
Carbamazépine
Carbamezepine
Carbatrol
Carbatrol extended-release
Carbazepin
Carbazepine
Carbelan
ChemDiv1_018966
D00252
DB00564
DivK1c_000388
DivK1c_003750
EINECS 206-062-7
EU-0100292
Epitol
Epitol, Equetro, Tegretol, Biston, Calepsin, Carbamazepine
Equetro
Equetro (TN)
Finlepsin
G 32883
G-32883
Geigy 32883
HMS1568K05
 
HMS1920I17
HMS2090M07
HMS2091O19
HMS501D10
HMS640O02
HSDB 3019
I06-0863
IDI1_000388
KBio1_000388
KBio2_000516
KBio2_003084
KBio2_005652
KBio3_001149
KBioGR_000724
KBioSS_000516
Karbamazepin
LS-60362
Lexin
Lopac-C-4024
Lopac0_000292
MLS000069652
MLS001055475
MLS001074172
Mazepine
MolPort-000-710-574
NCGC00015234-01
NCGC00015234-02
NCGC00015234-03
NCGC00015234-07
NCGC00015234-13
NCGC00023877-03
NCGC00023877-04
NCGC00023877-05
NCGC00023877-06
NCGC00023877-07
NCGC00023877-08
NINDS_000388
NSC 169864
NSC169864
Neurotol
Neurotop retard
Novo-Carbamaz
Nu-Carbamazepine
Oprea1_790775
Prestwick0_000052
Prestwick1_000052
Prestwick2_000052
Prestwick3_000052
Prestwick_104
S1693_Selleck
SAM002264603
SMR000058201
SMR001227191
SPBio_000170
SPBio_002124
SPD-417
SPECTRUM1500159
STK177357
Sirtal
Spectrum2_000125
Spectrum3_000325
Spectrum4_000262
Spectrum5_000936
Spectrum_000096
Stazepin
Stazepine
Taro-Carbamazepine
Taro-Carbamazepine Cr
Tegretal
Tegretol
Tegretol (TN)
Tegretol Chewtabs
Tegretol Cr
Tegretol XR
Tegretol-Xr
Telesmin
Teril
Timonil
Trimonil
UNII-33CM23913M
WLN: T C676 BNJ BVZ
ZINC00004785
benzo[b][1]benzazepine-11-carboxamide
carbamazepine
carbamazepine (Tegretol)
nchem.859-comp7
23
Valproic Acidapproved, investigationalPhase 331199-66-13121
Synonyms:
(N-C3H7)2CHCOOH
(S)-2-propyl-4-pentanoate
(S)-2-propyl-4-pentanoic acid
2 PP (base)
2-N-Propyl-N-valeric acid
2-PROPYL-pentanoic acid
2-Propyl-Pentanoate
2-Propyl-Pentanoic acid
2-Propylpentanoate
2-Propylpentanoic Acid
2-Propylpentanoic acid
2-Propylvaleric Acid
2-Propylvaleric acid
2-n-Propyl-n-valeric acid
2-n-propyl-n-valeric acid
2-propylvaleric acid
4-Heptanecarboxylic acid
4-heptanecarboxylic acid
76584-70-8 (hydrochloride salt (2:1))
99-66-1
AC1L1F7T
AC1Q2ULA
AI3-10500
APO-divalproex
Abbott 44090
Acide valproique
Acide valproique [INN-French]
Acide valproique [inn-french]
Acido valproico
Acido valproico [INN-Spanish]
Acido valproico [inn-spanish]
Acidum valproicum
Acidum valproicum [INN-Latin]
Acidum valproicum [inn-latin]
Alti-Valproic
Alti-valproic
Apo-valproic
Apo-valproic syrup
Avugane
BIDD:GT0858
BRN 1750447
Baceca
C07185
CHEBI:39867
CHEMBL109
CID3121
CPD000499581
Convulex
Convulsofin
D00399
DB00313
DOM-divalproex
DOM-valproic
DOM-valproic acid E.C.
DPA
Delepsine
Depacon
Depakene
Depakene (TN)
Depakin
Depakin chrono
Depakine
Depakine chrono
Depakote
Depakote (TM)
Depakote ER
Deproic
Di-N-propylacetic acid
Di-N-propylessigsaeure
Di-N-propylessigsaure
Di-N-propylessigsaure [german]
Di-n-propylacetic acid
Di-n-propylessigsaeure
Di-n-propylessigsaure
Di-n-propylessigsaure [German]
Di-n-propylessigsäure
Dipropyl Acetate
Dipropylacetate
Dipropylacetic acid
DivK1c_000273
Divalproex
Dom-Valproic
Dom-valproate
Dom-valproic acid
Dom-valproic acid syrup
EINECS 202-777-3
Epiject I.V.
Epilex
Epilim
Epival
Epival er
Ergenyl
G2M-777
Gen-divalproex
HMS2089J06
HSDB 3582
I04-0211
InChI=1/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
KBio1_000273
KBio2_001001
KBio2_002277
KBio2_003569
KBio2_004845
 
KBio2_006137
KBio2_007413
KBio3_002626
KBio3_002757
KBioGR_000871
KBioGR_002277
KBioSS_001001
KBioSS_002278
Kyselina 2-propylvalerova
Kyselina 2-propylvalerova [Czech]
LS-161170
LS-2068
MLS001076682
MLS001335927
MLS001335928
MLS002415770
Med Valproic
Med valproic
MolPort-001-791-895
Mylproin
Myproate
Myproic Acid
Myproic acid
N-DPA
N-Dipropylacetic acid
NCGC00091149-01
NCGC00091149-02
NCGC00091149-03
NCGC00091149-04
NINDS_000273
NSC 93819
NSC93819
Novo-Valproic
Novo-Valproic - ECC
Novo-divalproex
Novo-valproic
Novo-valproic soft gel cap
Nu-Valproic
Nu-valproic
P0823
P6273_SIGMA
PEAC
PHL-valproate
PHL-valproic acid
PHL-valproic acid E.C.
PMS-Divalproex
PMS-Valproic Acid
PMS-valproate
PMS-valproic acid
PMS-valproic acid E.C.
Penta-Valproic
Penta-valproic
Propylvaleric acid
Ratio-Valproic - ECC
S(-)-4-En-valproate
S(-)-4-En-valproic acid
S-2-N-Propyl-4-pentenoate
S-2-N-Propyl-4-pentenoic acid
SAM002564230
SBB065764
SMR000499581
SPBio_000912
Sandoz valproic
Savicol
Semisodium Valproate
Sodium hydrogen divalproate
Spectrum2_000946
Spectrum3_001733
Spectrum4_000376
Spectrum_000521
Sprinkle
Stavzor
UNII-614OI1Z5WI
VALPROIC ACID
VALPROIC acid
VPA
Valcote
Valparin
Valproate
Valproate Semisodium
Valproate semisodique [French]
Valproate semisodium
Valproato semisodico [Spanish]
Valproatum seminatricum [Latin]
Valproic
Valproic Acid
Valproic Acid, Sodium Salt (2:1)
Valproic acid
Valproic acid (USP)
Valproic acid USP
Valproic acid USP24
Valproic acid [USAN:INN:BAN]
Valproic acid [usan:ban:inn]
Valproinsaeure
Valproinsäure
Vupral
WLN: QVY3 & 3
di-n-propylacetic acid
n-DPA
n-Dipropylacetic acid
nchembio.79-comp4
nchembio815-comp21
valproate
valproic acid
24
LacosamideapprovedPhase 376860352-01-8, 175481-36-4219078
Synonyms:
( )-(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide
(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide
(2R)-2-acetamido-N-benzyl-3-methoxypropanamide
175481-36-4
AC1L560M
ADD 234037
ADD-234037
AKOS005146274
AZD7762
CHEBI:188739
CHEMBL58323
CID219078
D07299
 
Erlosamide
Erlosamide [INN]
Erlosamide, Vimpat, Lacosamide
Harkoseride
I01-7424
LS-185541
Lacosamide
Lacosamide (USAN/INN)
Lacosamide [USAN]
S1253_Selleck
SPM 927
SPM-927
SPM-929
Vimpat
ZINC00007673
25
Octreotideapproved, investigationalPhase 319883150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
 
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Ocphyl
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide acetate
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatin
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
26PiracetamPhase 31367491-74-9
27Nootropic AgentsPhase 3604
28Psychotropic DrugsPhase 35501
29Tranquilizing AgentsPhase 33597
30Protective AgentsPhase 35651
31Neuroprotective AgentsPhase 31376
32Analgesics, Non-NarcoticPhase 35184
33Neurotransmitter AgentsPhase 314795
34AnticonvulsantsPhase 32249
35AnalgesicsPhase 39358
36Antimanic AgentsPhase 3663
37EtiracetamPhase 3196
38Central Nervous System DepressantsPhase 310016
39VaccinesPhase 26085
40MF59 oil emulsionPhase 296
41
LactitolPhase 2320585-86-43871
Synonyms:
4-O-b-D-Galactopyranosyl-D-glucitol, 9CI
E966
Emportal
 
Floralac
Importal
Oponaf
Portolac
42Adjuvants, ImmunologicPhase 21783
43
Mentholapproved19992216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
999 Itch Relief
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
Absorbine Back Therapeutic Pain Relief
Absorbine Jr
Absorbine Jr Ultra Strength Pain Relieving
Absorbine Jr.
Absorbine Jr. Back
Algomend Pain Relief
Alhua Huogan Pain Relieving Patch
Aloemint Skin Aid
Amar Ice
Analgesic
Anc Neverpain External Analgesic
Anti Itch
Army Health Pain Reliever
Arthri-support
Arthri-zen Relief
Arthripain Relief
Arthritis Relief
Aspercreme Heat
Aspercreme Max No Mess Roll On
Assured Cold N Hot Pain Relief Menthol
Assured Extra Strength Cold N Hot
Assured Ice Cold Topical Analgesic
Assured Muscle Rub
Assured Pain Relief Hot Menthol
Atopalm Pain Relieving
Aurorae Healing Pain Relieving Roll-on
Avapta
Avedana Pain Relieving Roll On
Avedana Pain-relieving
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
Babyganics Cold Relief Chest Rub
Barox
Barox BODY CARE MASSAGE
Barox Body Care Massage Relax Refresh Revital
Being Well Extra Strength Menthol Heat
Bengay Ultra Strength Large Size
Bengay Ultra Strength Pain Relieving Large Size
Bengay Ultra Strength Pain Relieving Regular Size
Bengay Ultra Strength Regular Size
Bengay Vanishing Scent
Bengay Zero Degrees Menthol Pain Relieving
Bentasil SUGAR FREE BLACKCURRANT SOFT Texture
Bentasil SUGAR FREE CHERRY SOFT Texture
Bentasil SUGAR FREE HONEY LEMON SOFT Texture
Berri-freez
Besthealth Cherry
Besthealth Cough Suppressant Sugar Free Black Cherry Flavor
Besthealth Cough Suppressant Sugar Free Honey Lemon Flavor
Besthealth Honey Lemon
Besthealth Menthol
Bio 2 Brazilian Heat Brazilian Heat
Bio-scriptives Extreme Pr
Bioblast Pain Relief
Bioflexor
Biofreeze
Biofreeze Colorless
Biofreeze Colorless Roll-on
Biofreeze Roll-on
Biorelief Ice Pain Relieving
Blistex Ivarest Medicated Poison Ivy Cleansing Foam
Blue Gel Pain Relieving
Blue Ice
Blue Ice Analgesic
Blue Ice Analgesic Gel
Blue Ice Pain Relieving
Body
Budpack Muscle Rub
Budpak Muscle Rub
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Canker Complete Canker Sore Relief
Caswell No. 540
Celadrin
Cepacol Sore Throat From Post Nasal Drip
Cepacol Sore Throat Regular Strength
Ching Wan Hung Soothing Herbal Balm
Choice Personal Care Theraputic Blue Ice
Cold Hot Patch
Cold Spot Point Relief
Coldaid
Cool N Heat Patch For Back Extra Strength
Coralite Extra Strength Menthol Pain Relief Sleeve - Knee
Coralite Extra Strength Menthol Pain Relief Sleeve - Wrist
Coralite Pain Relief
Counteract Cough Drops Honey Lemon
Counteract Cough Drops Orchard Cherry
Cryogel Island Rain Natural Pain Relieving Vitaminerals
Cvs Cold Hot Medicated
Cvs Soothing Itch Relief
Cvs Sore Muscle Rub Vanishing Scent
Cvs Therapeutic Menthol Gel
Cvs Therapeutic Menthol Pain Reliever
Cvs Tropical Citrus Cough
Cvs Ultra Strength Pain Relieving
Cvs Vanishing Scent Muscle Rub
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
Dg Health Extra Strength Medicated
Dg Health Pain Relieving
Dg Ice Cold Analgesic
Diapedic Foot Treatment
DivK1c_000820
Dorflex Icy Hot Flexible, Large
Dorflex Icy Hot Flexible, Small
Dorflex Icy Hot Flexible, XL
Dr. Blue
Dt Ice Cold Analgesic
Dual Action Cherry Cough Suppressant Oral Anesthetic
Dynafreeze
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
Easy
Eb301ap Pain Relief
Eb301ct Bruise Pain Relief
Eb302 Arthritis Relief
Ecolyptus Pain Relieving Muscle Rub
Efac Pain Relieving
Elgin Pain Relief
Equaline Blue Ice Pain Relieving
Equate Menthol Extra Strength
Eros Iron Man
Eucalyptamint
Eucerin Calming Itch Relief Treatment
Extra Strength Cold N Hot Pain Relief Medicated
Extra Strength Pain Relief Therapy
Extra Strength Stopain Cold Pain Relieving
Extra Strength Stopain Cold Pain Relieving Roll On
FEMA No. 2665
Family Care Maximum Strength Medicated Anti Itch
Fast Freeze
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
Flexall Pain Relieving
Flexgen
Fluaid
Foot Works Achy Foot Massager Pain Relieving
Gold Bond Foot Extra Strength
Gold Bond Medicated Foot
Gold Bond Pain Relieving Foot
Gold Bond Pain Relieving Foot Roll On
Green Bamboo
Green Guard Cough Drop Relief
HMS1922G13
HMS2092L14
HMS502I22
HSDB 5662
HSDB 593
Halls Apple Cider
Halls Butterscotch
Halls Cherry
Halls Extra Strong Menthol
Halls Honey Lemon
Halls Ice Peppermint
Halls MENTHO-LYPTUS
Halls Melon Splash
Halls Menthol
Halls Mentholyptus
Halls Mocha Mint
Halls Naturals Honey Lemon Chamomile
Halls Plus Cherry
Halls Plus Honey
Halls Plus Strawberry
Halls Spearmint
Halls Strawberry
Halls Sugar Free Black Cherry
Halls Sugar Free Citrus Blend
Halls Sugar Free Extra Strong Menthol
Halls Sugar Free Honey Berry
Halls Sugar Free Honey Lemon
Halls Sugar Free Mountain Menthol
Halls Tropical Fruit
Hallsmelon Splash Melon Splash
Hallssugar Free Extra Sugar Free Extra Strong Menthol
Han Honey Loquat Syrup
Hanbang Cataplasma
Harmon Extra Strength Pain Relieving
Harmon Extra Strength Pain Relieving Roll-on
Headache crystals
Health Smart Medicated Foot
Herbion Naturals Honey Lemon
Herbion Naturals Honey Lemon Cough Drops
Herbion Naturals Honey-Lemon Cough Drops
Herbion Naturals Mint Cough Drops
Herbion Naturals Orange
Herbion Naturals Orange Cough Drops
Hexahydrothymol
Hielo Ardiente
Honibe
 
Hot Ice Soothing Analgesic Gel
Huitomi Slimming Sports
Humphreys Bendito Alcoholado
I06-1216
I14-7371
IDI1_000820
Ice
Ice Cold Analgesic
Ice Cold Topical Analgesic Gel
Ice External Analgesic Leader
Ice Quake
Ice Quake Muscle Rub
Icy Cool Maximum Strength
Icy Hot
Icy Hot Back
Icy Hot Medicated
Icy Hot Medicated No Mess Applicator
Icy Hot Medicated Roll Large
Icy Hot Medicated Roll Medium
Icy Hot Medicated Roll, Large
Icy Hot Medicated Roll, Medium
Icy Hot Medicated, Advanced Relief
Icy Hot Medicated, Back
Icy Hot Medicated, XL
Icy Hot Naturals
Icy Hot Power Gel
Icy Hot Vanishing Scent
Icyhot Medicated
Imada Four Seasons Safe Analgesic Balm
Jakemans Blueberry
Jakemans Cherry
Jakemans Peppermint
K2 Cold Therapy
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
Kay Medic Menthol Pain Relief
Kool Comfort
Kool Comfort Pain Relieving Roll-on
Kpp Triple Action
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
La Jiao Feng Shi Gao
Lander Polar Ice
Leader Cough Drops Cherry Flavor
Leader Cough Drops Honey Lemon
Leader Cough Drops Menthol Flavor
Leader Extra Strength Medicated Pain Relief Patch
Leader Sugar Free Cough Drops Black Cherry
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
Linkus Lozenges Cough Suppressant/Oral Anesthetic
Low Sugar Cherry Flavor Fishermans Friend Menthol Cough Suppressant
Ludens Honey Lemon Throat Drops
Ludens Honey Licorice Throat Drops
Ludens Original Menthol Throat Drops
Lurosil
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Makesense Extra Strength Muscle Rub
Maxfit Freeze Gel
Maybelline New York Baby Lips Dr Rescue Medicated Balm
Medi First Plus Cherry Cough Drops
Medi-first Cherry Cough Drops
Medic Ice
Medicated Body Powder
Medicated Pain Relief
Mediflex
Medique Medikoff Drops
Medique Sugar Free Medikoff Drops
Meditowel PAIN RELIEF
Meijer Cherry Cough Drops
Meijer Honey Lemon Cough Drops
Meijer Menthol Cough Drops
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol Fresh Cough Suppressant
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Mentholatum Pain Relief Extra Strength
Mentholatum Sports Pain Relief Cold
Menthomenthol
Menthyl alcohol
Mineral Ice Pain Relieving
Miracle Foot Repair
Miracle Foot Repair Cream
Miracle Of Aloe Rub Roll On
Miracle Pain Cream
Moisture Therapy Anti-Itch
MolPort-000-849-729
MolPort-001-793-392
Moore Medical Cherry Cough Suppressant/anesthetic Drops
Moore Medical Sugar Free Black Cherry Cough Suppressant/anesthetic Drops
Moore Medical Sugar Free Menthol Cough Suppressant/anesthetic Drops
Mr Dudleys Topical Pain Relief
Muscle
Muscle Rub Ultra Strength Pain Relieving
Myo-breathe
Myorx Low Dose Pain Relieving
Myorx Pain Relieving
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Nan San Easy Flex Pain Relieving
Natural Cherry Honey Herb Throat Drops
Natural Herb cough drop
Natural Honey Herb Cough Suppressant Throat Drops
Natural Lemon Mint Herb Throat Drops
Natural Pain Relieving Lavender Breeze Cryogel
Natures Choice Cool Hot Ice
Natures Sunshine Products Everflex Topical Analgesic Pain Relief
Neoisomenthol
Nice Assorted
Nice Cherry
Nice Citrus
Nice Cool Mint
Nice Honey Lemon
Nice Menthol
No Pain More Gain
North Cough Drop
Numotizine
Olbas Lozenges Maximun Strength
Olbas Pastilles
Original Extra Strong All Natural Fishermans Friend Menthol Cough Suppressant
Ortho-nesic
Osmoflex
Oxyrub Pain Relief
Pain Relief Balmpreferred Plus Ph Preferred Plus Pharmacy
Pain Relief Therapy Patch
Pain Reliever
Pain Relieving
Pain Relieving Analgesic
Pain Relieving Patch
Pain Relieving Patch Ultra Strength
Pain Relieving Patch Ultra Strength ULTRA STRENGTH
Panitrol XR
Paraid Extra Strength Menthol Pain Relief Sleeve Knee Large Ankles Elbows
Patch Scherer Labs
Patch Walgreens
Peppermint camphor
Perfect Purity Hotice
Perfect Purity Medicated Foot Powder
Perform
Personal Care Extra Strength Cold Hot
Personal Care Ice Cold
Plaster MandAHerbalPlaster
Po Sum On Medicated
Polar Frost Cold
Power Relief
Preferred Plus Body Powder
Premier Value Medicated Foot Powder
Q Health Pain Relief Spray
Quickflex
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Raw Heat
Raw Ice
Reactice Reactivating Ice Baume
Red Lion Relief
Relief Pain Relieving Cream
Rexall Vanishing Scent Pain Relieving
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Screamin Menthol Toast
Sella Natural
Skin So Soft Bug Guard Plusitch Relief itch relief
Smith Bros Honey Lemon Cough Drops
Smith Bros Menthol Eucalyptus Cough Drops
Smith Bros Sugar-free Black Cherry Cough Drops
Sof Skin Icy Blue
Sofskin Ice Analgesic
Sombra Cool Therapy
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Stopain Cold Pain Relieving
Stopain Cold Professional Strength Pain Relieving
Stopain Extra Strength Pain Relieving
Sub-zero COOL PAIN RELIEVING
Sugar Free Cherry Fishermans Friend Menthol Cough Suppressant
Sugar Free Cherry Herb Throat Drops
Sugar Free Lemon Mint Herb Throat Drops
Sugar Free Mountain Herb Cough Suppressant Throat Drops
Sugar Free Original Swiss Herb Cough Suppressant Throat Drops
Sugar Free Refreshing Mint Fishermans Friend Menthol Cough Suppressant
Sugar Free Swiss Cherry Herb Throat Drops
The Medicine Shoppe Extra Strength Pain Relieving
The Original Natural Herb Cough Drops
Therafreeze
Theraid
Therapeutic Relief Preferred Plus Pharmacy
Theraplus Plus
Throat Coat
Tianhe Guben Yaoshen Tie Gao
Top Care Medicated
Topcare Medicated
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
Ultra Strength Stopain Pain Relieving
Us Favorite Cold Pain Relieving
Vaporizing Colds Rub
Vicks Vapodrops Cough Relief
Vitaminerals Inc. Cryogel Natural Pain Relieving
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
Walgreens Aloe Vera Cooling
Watermelon Frost Sore Throat
Wellpatch Backache Pain Relief
Xtracare Ice Cold Topical Analgesic Gel
Youngevity Invision CM
Yun Xiang Jing
ZINC01482164
Zhong Hua Jiu Patch
Zims Arnica Max
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
44Immunoglobulins4477
45Sulfalene73
46Antibodies4477
47
Salmeterol xinafoate32694749-08-356801
Synonyms:
(+-)-4-Hydroxy-alpha(sup 1)-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-m-xylene-alpha,alpha'-diol 1-hydroxy-2-naphthoate (salt)
(+/-) 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol xinafoate
1,3-Benzenedimethanol, 4-hydroxy-alpha(sup 1)-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-, (+-)-, 1-hydroxy-2-naphthalenecarboxylate (salt)
1-hydroxynaphthalene-2-carboxylic acid
2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol
89365-50-4 (Parent)
94749-08-3
AC1L1LPS
Arial
Asmerole
Beglan
Betamican
Bio-0096
C25H37NO4.C11H8O3
CHEMBL1082607
CID56801
D00687
Dilamax
EU-0101100
GR 33343 G
GR 33343X xinafoate
 
GR-33343 G
Inaspir
LS-94516
MLS001332577
MLS001332578
MolPort-003-850-218
NCGC00094372-01
NCGC00094372-02
NCGC00094372-03
NCGC00094372-04
S5068_SIGMA
SMR000875207
Salmetedur
Salmeterol 1-hydroxy-2-naphthoate
Salmeterol xinafoate (JAN/USAN)
Salmeterol xinafoate [USAN]
Serevent (TN)
Serevent Inhaler and Disks
Serevent diskus
UNII-6EW8Q962A5
Ultrabeta
salmeterol xinafoate
48Respiratory System Agents3931
49Glucagon-Like Peptide 1620
50Hypoglycemic Agents4503

Interventional clinical trials:

idNameStatusNCT IDPhase
1Extension Study to Compare Long-term Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With RVOCompletedNCT01580020Phase 4
2Levetiracetam Versus Standard Antiepileptic Drugs (Carbamazepine and Valproate) Used as Monotherapy in Patients With Newly Diagnosed EpilepsyCompletedNCT00175903Phase 3
3Safety and Efficacy of Lacosamide as Additional Therapy in Patients Suffering From Epileptic Tonic Clonic SeizuresEnrolling by invitationNCT02408549Phase 3
4Safety and Biological Activity of C2L-OCT-01 PR in Acromegalic PatientsTerminatedNCT00642421Phase 3
5Safety and Immunogenicity of Two Doses of a Tetravalent Influenza Vaccine in Adults Aged 18 Years and AboveCompletedNCT00620815Phase 2
6Genetic & Environmental Determinants Of Immune Phenotype Variance: Establishing A Path Towards Personalized MedicineCompletedNCT01699893
7Effect of a Mixture of Probiotics on the Antigen Specific Antibody Response in a Influenza Vaccination Model of Healthy AdultsCompletedNCT01652066
8Sleep and Memory in ChildrenRecruitingNCT02785328
9Uncontrolled Lower Respiratory Symptoms in the WTC Survivor ProgramRecruitingNCT02024204
10Incretin-mimetic Hypoglycemic Drugs and Severe RetinopathyRecruitingNCT02671864

Search NIH Clinical Center for Nijmegen Breakage Syndrome


Cochrane evidence based reviews: nijmegen breakage syndrome

Genetic Tests for Nijmegen Breakage Syndrome

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Genetic tests related to Nijmegen Breakage Syndrome:

id Genetic test Affiliating Genes
1 Nijmegen Breakage Syndrome22 NBN

Anatomical Context for Nijmegen Breakage Syndrome

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MalaCards organs/tissues related to Nijmegen Breakage Syndrome:

33
Breast, Kidney, Lung, T cells, Prostate, Thymus, Endothelial

Animal Models for Nijmegen Breakage Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Nijmegen Breakage Syndrome:

38 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.8ATR, BRCA1, RAD50, TP53
2MP:00053758.3ATM, ATR, BRCA1, TP53, WRN
3MP:00107718.1ATM, ATR, BRCA1, RAD50, TP53, WRN
4MP:00053817.9ATR, BRCA1, LIG4, RAD50, TP53, WRN
5MP:00053807.9ATM, ATR, BRCA1, MRE11A, NBN, RAD50
6MP:00053867.4ATM, ATR, BRCA1, LIG4, MRE11A, NBN
7MP:00036317.4ATM, ATR, BRCA1, LIG4, MRE11A, NBN
8MP:00053796.8ATM, ATR, BRCA1, H2AFX, LIG4, NBN
9MP:00053786.5ATM, ATR, BRCA1, H2AFX, LIG4, NBN
10MP:00053896.4ATM, ATR, BRCA1, H2AFX, LIG4, MRE11A
11MP:00053766.1ATM, ATR, BRCA1, CHEK2, H2AFX, LIG4
12MP:00020066.0ATM, ATR, BRCA1, CHEK2, H2AFX, LIG4
13MP:00053845.8ATM, ATR, BRCA1, CHEK2, H2AFX, LIG4
14MP:00107685.7ATM, ATR, BRCA1, CHEK2, H2AFX, LIG4
15MP:00053875.6ATM, ATR, BRCA1, CHEK2, H2AFX, LIG4
16MP:00053975.5ATM, ATR, BRCA1, CHEK2, H2AFX, LIG4

Publications for Nijmegen Breakage Syndrome

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Articles related to Nijmegen Breakage Syndrome:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Clinical course and therapeutic implications for lymphoid malignancies in Nijmegen breakage syndrome. (26826318)
2016
2
Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application. (26265251)
2015
3
The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes. (25119968)
2014
4
Celiac-like sprue in Nijmegen breakage syndrome: successful treatment with budesonide. (24834778)
2014
5
Clinical significance of increased expression of Nijmegen breakage syndrome gene (NBS1) in human primary liver cancer. (26202506)
2014
6
Significant association between Nijmegen breakage syndrome 1 657del5 polymorphism and breast cancer risk. (23765759)
2013
7
Nijmegen breakage syndrome with macrocephaly, schizencephaly and large CSF spacesa89extended spectrum of the condition. (22293976)
2012
8
Astrocyte dysfunction associated with cerebellar attrition in a Nijmegen breakage syndrome animal model. (21279473)
2011
9
A novel defect in mitochondrial p53 accumulation following DNA damage confers apoptosis resistance in Ataxia Telangiectasia and Nijmegen Breakage Syndrome T-cells. (20947454)
2010
10
Mutational inactivation of the nijmegen breakage syndrome gene (NBS1) in glioblastomas is associated with multiple TP53 mutations. (19151620)
2009
11
Non-Hodgkin lymphoma (NHL) in children with Nijmegen Breakage syndrome (NBS). (18937313)
2009
12
DNA double-strand break and chromosomal rejoining defects with misrejoining in Nijmegen breakage syndrome cells. (17919995)
2008
13
The R215W mutation in NBS1 impairs gamma-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients. (18328813)
2008
14
Mutations in the Nijmegen breakage syndrome gene in medulloblastomas. (18593981)
2008
15
Cutaneous noncaseating granulomas associated with Nijmegen breakage syndrome. (18347309)
2008
16
Nijmegen breakage syndrome. (17712992)
2007
17
Differentiation of Nijmegen breakage syndrome from Fanconi anemia. (18050081)
2007
18
NBS1, the Nijmegen breakage syndrome gene product, regulates neuronal proliferation and differentiation. (17442057)
2007
19
Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients. (16309973)
2006
20
Screening of Nijmegen breakage syndrome 1 mutations in four unrelated families by polymerase chain reaction using sequence-specific primers. (16544999)
2006
21
No evidence of significant silencing of Fanconi genes FANCF and FANCB or Nijmegen breakage syndrome gene NBS1 by DNA hyper-methylation in sporadic childhood leukaemia. (16803569)
2006
22
Impaired elimination of DNA double-strand break-containing lymphocytes in ataxia telangiectasia and Nijmegen breakage syndrome. (16765653)
2006
23
Radiation-induced DNA damage and repair in peripheral blood mononuclear cells from Nijmegen breakage syndrome patients and carriers assessed by the Comet assay. (16470524)
2006
24
Nijmegen breakage syndrome (NBS) with neurological abnormalities and without chromosomal instability. (16033915)
2006
25
Nijmegen breakage syndrome in Slovakia]. (15446459)
2004
26
An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability. (15333589)
2004
27
Magnetic resonance imaging of brain abnormalities in patients with the Nijmegen breakage syndrome. (15586667)
2004
28
The clinical and biological overlap between Nijmegen Breakage Syndrome and Fanconi anemia. (15451479)
2004
29
Rhabdomyosarcoma in Nijmegen breakage syndrome: strong association with perianal primary site. (15474156)
2004
30
Mutation analysis of the Nijmegen breakage syndrome gene (NBS1) in nineteen patients with acute myeloid leukemia with complex karyotypes. (14738145)
2003
31
Nijmegen breakage syndrome: a neuropathological study. (12973659)
2003
32
Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability. (12483513)
2002
33
Radiosensitivity of ataxia telangiectasia and Nijmegen breakage syndrome homozygotes and heterozygotes as determined by three-color FISH chromosome painting. (11839094)
2002
34
Cavernous sinus thrombophlebitis in Nijmegen breakage syndrome. (12160977)
2002
35
Cranial MRI in the Nijmegen breakage syndrome. (10663471)
2000
36
Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres. (10811102)
2000
37
Positional cloning and functional analysis of the gene responsible for Nijmegen breakage syndrome, NBS1. (10838806)
2000
38
Expression pattern of the Nijmegen breakage syndrome gene, Nbs1, during murine development. (10915761)
2000
39
Nijmegen breakage syndrome. The International Nijmegen Breakage Syndrome Study Group. (10799436)
2000
40
Nijmegen breakage syndrome-associated T-cell-rich B-cell lymphoma: case report. (10742414)
2000
41
Immortalization and characterization of Nijmegen Breakage syndrome fibroblasts. (10377945)
1999
42
Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1. (9933573)
1999
43
G2 repair in Nijmegen breakage syndrome: G2 duration and effect of caffeine and cycloheximide in control and X-ray irradiated lymphocytes. (9650762)
1998
44
Chromosomal sensitivity to clastogenic agents and cell cycle perturbations in Nijmegen breakage syndrome lymphoblastoid cell lines. (9020962)
1997
45
A variant of the Nijmegen breakage syndrome with unusual cytogenetic features and intermediate cellular radiosensitivity. (9132489)
1997
46
The gene for Nijmegen breakage syndrome (V2) is not located on chromosome 11. (8644753)
1996
47
Severe intrauterine growth retardation with increased mitomycin C sensitivity, or Nijmegen breakage syndrome? (8825936)
1995
48
Genetic complementation analysis of ataxia telangiectasia and Nijmegen breakage syndrome: a survey of 50 patients. (3248383)
1988
49
A new chromosomal instability disorder: the Nijmegen breakage syndrome. (7315300)
1981
50

Variations for Nijmegen Breakage Syndrome

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Clinvar genetic disease variations for Nijmegen Breakage Syndrome:

5 (show all 23)
id Gene Variation Type Significance SNP ID Assembly Location
1NBNNM_002485.4(NBN): c.698_701delAACA (p.Lys233Serfs)deletionPathogenicrs587780100GRCh37Chr 8, 90983402: 90983405
2NBNNM_002485.4(NBN): c.1142delC (p.Pro381Glnfs)deletionPathogenicrs587781969GRCh37Chr 8, 90967766: 90967766
3NBNNM_002485.4(NBN): c.2140C> T (p.Arg714Ter)single nucleotide variantPathogenicrs730881864GRCh37Chr 8, 90955525: 90955525
4NBNNM_002485.4(NBN): c.808_809delGT (p.Val270Cysfs)deletionPathogenicrs786202490GRCh37Chr 8, 90982679: 90982680
5NBNNM_002485.4(NBN): c.2165G> A (p.Trp722Ter)single nucleotide variantPathogenicrs786204181GRCh37Chr 8, 90955500: 90955500
6NBNNM_002485.4(NBN): c.1030C> T (p.Gln344Ter)single nucleotide variantPathogenicrs767215758GRCh38Chr 8, 89958819: 89958819
7NBNNM_002485.4(NBN): c.842T> G (p.Leu281Ter)single nucleotide variantPathogenicrs786205135GRCh38Chr 8, 89970418: 89970418
8NBNNM_002485.4(NBN): c.1030C> T (p.Gln344Ter)single nucleotide variantPathogenicrs767215758GRCh38Chr 8, 89958819: 89958819
9NBNNM_002485.4(NBN): c.2185-?_*(1_?)deldeletionLikely pathogenicGRCh38Chr 8, 89935581: 89937075
10NBNNM_002485.4(NBN): c.211_212insGA (p.Asn71Argfs)insertionPathogenicrs762664474GRCh37Chr 8, 90993711: 90993712
11NBNNM_002485.4(NBN): c.897-?_2184+?deldeletionPathogenic
12NBNNM_002485.4(NBN): c.897-2A> Tsingle nucleotide variantLikely pathogenicrs864622090GRCh37Chr 8, 90976737: 90976737
13NBNNM_002485.4(NBN): c.1747C> Tsingle nucleotide variantPathogenicrs864622143GRCh37Chr 8, 90965570: 90965570
14NBNNM_002485.4(NBN): c.93_94delTGdeletionPathogenicrs864622253GRCh37Chr 8, 90995027: 90995028
15NBNNM_002485.4(NBN): c.1419_1431dupAGAAATGTCTTCAduplicationPathogenicrs864622333GRCh37Chr 8, 90965886: 90965898
16NBNNM_002485.4(NBN): c.115delCdeletionPathogenicrs864622511GRCh37Chr 8, 90995006: 90995006
17NBNNM_002485.4(NBN): c.657_661delACAAA (p.Lys219Asnfs)deletionPathogenic, risk factorrs587776650GRCh37Chr 8, 90983442: 90983446
18NBNNM_002485.4(NBN): c.835_838delCAGAdeletionPathogenicrs864309668GRCh38Chr 8, 89970422: 89970425
19NBNNM_002485.4(NBN): c.842dupTduplicationPathogenicrs864309669GRCh38Chr 8, 89970418: 89970418
20NBNNM_002485.4(NBN): c.976C> T (p.Gln326Ter)single nucleotide variantPathogenicrs121908973GRCh37Chr 8, 90976656: 90976656
21NBNNM_002485.4(NBN): c.511A> G (p.Ile171Val)single nucleotide variantPathogenic, risk factorrs61754966GRCh37Chr 8, 90990521: 90990521
22NBNNM_002485.4(NBN): c.1089C> A (p.Tyr363Ter)single nucleotide variantPathogenicrs121908974GRCh37Chr 8, 90970988: 90970988
23NBNNM_002485.4(NBN): c.741_742dupGGduplicationPathogenicrs864309670GRCh37Chr 8, 90982746: 90982747

Expression for genes affiliated with Nijmegen Breakage Syndrome

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Search GEO for disease gene expression data for Nijmegen Breakage Syndrome.

Pathways for genes affiliated with Nijmegen Breakage Syndrome

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Pathways related to Nijmegen Breakage Syndrome according to GeneCards Suite gene sharing:

(show all 43)
idSuper pathwaysScoreTop Affiliating Genes
19.9MRE11A, NBN
2
Show member pathways
9.6MRE11A, NBN, RAD50
3
Show member pathways
9.3ATM, TP53
49.2ATM, MRE11A, NBN, RAD50
59.2BRCA1, TP53
69.1CHEK2, TP53
78.8ATM, MRE11A, NBN, RAD50, WRN
8
Show member pathways
8.8ATM, CHEK2, TP53
98.8ATM, ATR, TP53
10
Show member pathways
8.8ATM, ATR, TP53
118.7ATM, H2AFX, TP53
128.5ATM, ATR, CHEK2, H2AFX
13
Show member pathways
8.4ATM, BRCA1, MRE11A, NBN, RAD50, WRN
148.3BRCA1, LIG4, MRE11A, NBN, RAD50, WRN
158.3ATM, ATR, BRCA1, TP53
168.3ATM, ATR, BRCA1, TP53
17
Show member pathways
8.3ATM, ATR, CHEK2, TP53
18
Show member pathways
8.3ATM, ATR, CHEK2, TP53
19
Show member pathways
8.3ATM, ATR, CHEK2, TP53
208.3ATM, ATR, CHEK2, TP53
21
Show member pathways
8.3ATM, ATR, CHEK2, TP53
228.3ATM, ATR, CHEK2, TP53
23
Show member pathways
7.8ATM, ATR, BRCA1, MRE11A, NBN, RAD50
24
Show member pathways
7.8ATM, ATR, BRCA1, CHEK2, TP53
25
Show member pathways
7.6ATM, ATR, BRCA1, H2AFX, MRE11A, NBN
267.5ATM, ATR, BRCA1, CHEK2, NBN, TP53
277.4ATM, ATR, BRCA1, MRE11A, NBN, RAD50
287.3ATM, BRCA1, CHEK2, MRE11A, RAD50, TP53
29
Show member pathways
7.3ATM, ATR, H2AFX, MRE11A, NBN, RAD50
30
Show member pathways
7.2ATM, ATR, BRCA1, CHEK2, MRE11A, RAD50
317.2ATM, ATR, BRCA1, CHEK2, MRE11A, RAD50
32
Show member pathways
6.9ATM, ATR, BRCA1, CHEK2, MRE11A, NBN
33
Show member pathways
6.8ATM, BRCA1, CHEK2, H2AFX, MRE11A, NBN
34
Show member pathways
6.8ATM, ATR, BRCA1, H2AFX, MRE11A, NBN
35
Show member pathways
6.5ATM, ATR, BRCA1, CHEK2, LIG4, MRE11A
36
Show member pathways
6.5ATM, ATR, BRCA1, CHEK2, MRE11A, NBN
37
Show member pathways
6.4ATM, BRCA1, CHEK2, H2AFX, LIG4, MRE11A
38
Show member pathways
6.3ATM, ATR, BRCA1, CHEK2, H2AFX, MRE11A
396.3ATM, ATR, BRCA1, CHEK2, H2AFX, MRE11A
40
Show member pathways
5.9ATM, ATR, BRCA1, CHEK2, H2AFX, MRE11A
41
Show member pathways
5.9ATM, ATR, BRCA1, CHEK2, H2AFX, MRE11A
42
Show member pathways
5.9ATM, ATR, BRCA1, CHEK2, H2AFX, MRE11A
43
Show member pathways
5.5ATM, ATR, BRCA1, CHEK2, H2AFX, LIG4

GO Terms for genes affiliated with Nijmegen Breakage Syndrome

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Cellular components related to Nijmegen Breakage Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:00166058.0ATR, CHEK2, MRE11A, NBN, TP53

Biological processes related to Nijmegen Breakage Syndrome according to GeneCards Suite gene sharing:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1regulation of mitotic recombinationGO:000001910.6MRE11A, RAD50
2mitotic G2 DNA damage checkpointGO:000709510.5MRE11A, NBN
3reciprocal meiotic recombinationGO:000713110.4ATM, RAD50
4V(D)J recombinationGO:003315110.3ATM, LIG4
5positive regulation of telomerase catalytic core complex assemblyGO:190488410.2ATM, ATR
6establishment of RNA localization to telomereGO:009769410.2ATM, ATR
7cellular response to gamma radiationGO:007148010.2ATM, WRN
8positive regulation of DNA damage response, signal transduction by p53 class mediatorGO:004351710.2ATM, ATR
9negative regulation of telomere cappingGO:190435410.2ATM, NBN, RAD50
10DNA damage induced protein phosphorylationGO:000697510.2ATM, CHEK2
11positive regulation of kinase activityGO:003367410.2MRE11A, NBN, RAD50
12positive regulation of telomere maintenance via telomeraseGO:003221210.2ATM, ATR
13DNA duplex unwindingGO:003250810.2MRE11A, NBN, RAD50
14DNA double-strand break processingGO:000072910.1ATM, BRCA1
15telomeric 3 overhang formationGO:003186010.1MRE11A, NBN
16DNA damage response, signal transduction by p53 class mediatorGO:003033010.0NBN, TP53
17positive regulation of protein autophosphorylationGO:00319549.9MRE11A, NBN, RAD50
18determination of adult lifespanGO:00083409.9ATM, TP53
19positive regulation of neuron apoptotic processGO:00435259.9ATM, TP53
20positive regulation of DNA repairGO:00457399.8BRCA1, H2AFX
21base-excision repairGO:00062849.7TP53, WRN
22double-strand break repairGO:00063029.7ATM, TP53
23DNA recombinationGO:00063109.6BRCA1, LIG4, WRN
24cell agingGO:00075699.6TP53, WRN
25DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.6BRCA1, TP53
26intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.5ATM, BRCA1, CHEK2
27DNA synthesis involved in DNA repairGO:00007319.5ATM, BRCA1, NBN, RAD50
28protein autophosphorylationGO:00467779.5ATM, ATR, CHEK2
29nucleic acid phosphodiester bond hydrolysisGO:00903059.4MRE11A, RAD50, WRN
30DNA damage checkpointGO:00000779.4ATR, CHEK2, NBN
31double-strand break repair via nonhomologous end joiningGO:00063039.4BRCA1, H2AFX, LIG4
32DNA repairGO:00062819.2ATM, BRCA1, LIG4
33strand displacementGO:00007329.2ATM, MRE11A, NBN, RAD50, WRN
34double-strand break repair via homologous recombinationGO:00007249.1ATM, ATR, BRCA1, WRN
35protein sumoylationGO:00169259.1BRCA1, TP53, WRN
36response to gamma radiationGO:00103329.1CHEK2, LIG4, TP53
37response to ionizing radiationGO:00102129.1ATM, BRCA1, H2AFX, LIG4
38replicative senescenceGO:00903998.9ATM, CHEK2, TP53
39viral processGO:00160328.9LIG4, MRE11A, RAD50, TP53
40regulation of signal transduction by p53 class mediatorGO:19017968.8ATM, ATR, CHEK2, RAD50, WRN
41double-strand break repair via synthesis-dependent strand annealingGO:00450038.7ATM, BRCA1, MRE11A, NBN, RAD50, WRN
42DNA replicationGO:00062607.9ATR, BRCA1, LIG4, MRE11A, NBN, RAD50
43cellular response to DNA damage stimulusGO:00069746.9ATM, ATR, BRCA1, CHEK2, MRE11A, NBN

Molecular functions related to Nijmegen Breakage Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
13-5 exonuclease activityGO:000840810.1RAD50, WRN
2ATP-dependent DNA helicase activityGO:00040039.9MRE11A, RAD50
3ubiquitin protein ligase bindingGO:00316259.5CHEK2, TP53
4DNA bindingGO:00036778.1ATM, ATR, RAD50, TP53, WRN

Sources for Nijmegen Breakage Syndrome

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet