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NLPHL
MCID: NDL021
MIFTS: 42

Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL) malady

Cancer diseases, Blood diseases, Immune diseases categories
13 symptoms, 19 genes, 3 tissues, 72 related diseases, clinical trials.

Summaries for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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MalaCards: Nodular Lymphocyte Predominant Hodgkin Lymphoma, also known as NLPHL, is related to diffuse large b-cell lymphoma and sarcoma, and has symptoms including asthenia/fatigue/weakness, fever/chilling and weight loss/loss of appetite/break in weight curve/general health alteration. An important gene associated with Nodular Lymphocyte Predominant Hodgkin Lymphoma is PDCD1 (programmed cell death 1), and among its related pathways are Atypical NF-kappaB pathway and 4-1BB Pathway. The compounds monochloroacetic acid and manganese superoxide have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related mouse phenotypes are skeleton and growth/size.

Aliases & Classifications for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Sources:
48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases
ICD10: 26 25


Characteristics (Orphanet epidemiological data):

48
nodular lymphocyte predominant hodgkin lymphoma:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

nodular lymphocyte predominant hodgkin lymphoma 48 60
nlphl 48


External Ids:

ICD10 via Orphanet26 C81.1
SNOMED-CT via Orphanet57 118605002, 277608004, 70600005
UMLS via Orphanet61 C1334968, C2239290
ICD1025 C81.0

Related Diseases for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Nodular Lymphocyte Predominant Hodgkin Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1diffuse large b-cell lymphoma31.0MUM1
2sarcoma30.5VIM, CFLAR, PTPRC
3bone lymphoma10.5
4lung lymphoma10.4
5autoimmune hemolytic anemia10.4
6pediatric lymphoma10.4
7adult lymphoma10.4
8hermansky-pudlak syndrome10.4
9small intestine lymphoma10.4
10hepatitis a10.4
11cervicitis10.4
12hemolytic anemia10.4
13hepatitis10.4
14intestinal disease10.4
15polyradiculopathy10.4
16lymphocyte-rich classical hodgkin lymphoma10.4
17angioimmunoblastic t-cell lymphoma10.0BCL6
18testicular lymphoma10.0BCL6
19histiocytosis10.0CD68
20central nervous system lymphoma10.0BCL6
21cutaneous fibrous histiocytoma10.0CD68
22myeloid sarcoma10.0FUT4
23seminoma10.0TNFRSF8
24systemic lupus erythematosus10.0TNFAIP3, PDCD1
25myeloid leukemia10.0PTPRC
26herpes simplex10.0CFLAR, POU2F2
27lymphosarcoma10.0TNFRSF8, BCL6
28arthritis10.0NFKBIA, CFLAR
29adenoma10.0TNFRSF8
30sarcoidosis10.0PTPRC
31hepatitis c10.0PAX5
32myelodysplastic syndromes10.0CFLAR, NFKBIA
33atherosclerosis10.0CD68, NFKBIA
34malignant histiocytosis10.0TNFRSF8
35colorectal cancer10.0CFLAR, NFKBIA
36reticulosarcoma10.0BCL6, TNFRSF8, TIA1
37retinoblastoma10.0PTPRC, CARD16
38central nervous system lymphoma, primary10.0BCL6, PAX5
39angiomyolipoma10.0VIM, PTPRC
40lymphomatoid papulosis10.0TNFRSF8, TIA1
41nephrotic syndrome10.0NFKBIA, PTPRC
42tuberculosis10.0PTPRC, TNFRSF8
43mycosis fungoides10.0TIA1, TNFRSF8
44acute leukemia10.0PTPRC, PAX5
45multiple sclerosis10.0PDCD1, NFKBIA, CFLAR, PTPRC
46giant cell tumor10.0VIM, TNFRSF8, PTPRC
47lymphoblastic lymphoma10.0PAX5, PTPRC, BCL6
48ovarian cancer10.0CFLAR, REL, NFKBIA
49peripheral primitive neuroectodermal tumor10.0PTPRC, CFLAR, TNFRSF8, VIM
50malignant fibroxanthoma10.0VIM, TNFRSF8, CD68, PTPRC

Graphical network of the top 20 diseases related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:



Diseases related to nodular lymphocyte predominant hodgkin lymphoma

Clinical Features for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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48Orphanet
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Symptoms:

48 (show all 13)
  • asthenia/fatigue/weakness
  • fever/chilling
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • neoplasms/tumors
  • bone marrow failure/pancytopenia
  • anorexia
  • splenomegaly
  • hepatomegaly/liver enlargement (excluding storage disease)
  • pruritus/itching
  • hyperhidrosis/increased sweating
  • lymphoma
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • lymphadenopathy/polyadenopathies

Drugs & Therapeutics for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Drug clinical trials:

Search ClinicalTrials for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Search NIH Clinical Center for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Search CenterWatch for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Genetic Tests for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Anatomical Context for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

32
Liver, Bone, Bone marrow

Animal Models for Nodular Lymphocyte Predominant Hodgkin Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
skeleton phenotype
MP:00053909.1PTPRC, PAX5, CD68, PDCD1, TIA1
2
growth/size phenotype
MP:00053786.6TIA1, TNFAIP3, NFKBIA, POU2AF1, POU2F2, REL
3
mortality/aging
MP:00107686.2BCL6, TIA1, VIM, PDCD1, TNFAIP3, NFKBIA
4
cellular phenotype
MP:00053845.9VIM, PDCD1, TNFAIP3, NFKBIA, POU2AF1, POU2F2
5
hematopoietic system phenotype
MP:00053975.1TIA1, BCL6, PDCD1, TNFRSF8, TNFAIP3, NFKBIA
6
immune system phenotype
MP:00053874.8TNFRSF8, VIM, PDCD1, TNFAIP3, NFKBIA, POU2AF1

Publications for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Genetic Variations for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Expression for genes affiliated with Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nodular Lymphocyte Predominant Hodgkin Lymphoma

Search GEO for disease gene expression data for Nodular Lymphocyte Predominant Hodgkin Lymphoma.

Pathways for genes affiliated with Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 29KEGG
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Pathways related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Atypical NF-kappaB pathway37
10.0REL, NFKBIA
2
4-1BB Pathway51
Hide members
9.8NFKBIA, REL, TNFAIP3
3
NF-kappaB Signaling4
9.8TNFAIP3, NFKBIA, REL
4
TWEAK Pathway51
Hide members
9.8TNFAIP3, NFKBIA, REL
5
14-3-3 Induced Apoptosis51
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9.8TNFAIP3, CFLAR, NFKBIA
6
TNF signaling pathway29
9.8TNFAIP3, CFLAR, NFKBIA
7
NF-kappa B signaling pathway29
9.8TNFAIP3, NFKBIA, CFLAR
8
Immune response T cell receptor signaling pathway12
9.8REL, PTPRC, NFKBIA
9
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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9.5REL, NFKBIA, TNFRSF8
10
Immune response Fc epsilon RI pathway12
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9.4NFKBIA, BCL6, REL, PTPRC
11
B Cell Receptor Signaling Pathway37
9.4REL, NFKBIA, PTPRC, BCL6
12
Development Glucocorticoid receptor signaling12
9.4NFKBIA, POU2F2, REL
13
TNF-alpha/NF-kB Signaling Pathway37
9.0CFLAR, REL, TNFRSF8, NFKBIA, TNFAIP3
14
B cell receptor signaling pathway29
Hide members
8.6PTPRC, REL, POU2F2, NFKBIA, PDCD1, VIM

Compounds for genes affiliated with Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1monochloroacetic acid4410.2PTPRC, VIM
2manganese superoxide4410.1REL, NFKBIA, TNFAIP3
3dutp4410.0NFKBIA, CFLAR, CARD16
4toluidine4410.0VIM, PTPRC
5rituximab44 49 1111.9CFLAR, PAX5, BCL6
6serine449.7CFLAR, NFKBIA, POU2F2
7etoposide44 49 59 1112.6CARD16, VIM, NFKBIA, CFLAR
8vincristine44 49 1111.6CFLAR, VIM, BCL6
912-o-tetradecanoylphorbol 13-acetate449.5BCL6, PTPRC, NFKBIA, VIM
10[alcl]449.5TNFRSF8, PAX5, PTPRC, TIA1
11estradiol44 11 2411.4CFLAR, NFKBIA, VIM, PAX5
12adriamycin449.4VIM, CFLAR, NFKBIA
13h2o2449.4VIM, TNFAIP3, NFKBIA, CFLAR, PTPRC
14cyclosporin a44 28 5911.3NFKBIA, REL, CFLAR, PTPRC, TNFRSF8
15testosterone44 59 11 2412.3VIM, NFKBIA, CFLAR, PAX5, PTPRC
16doxorubicin44 49 1111.3BCL6, CFLAR, NFKBIA, VIM
17cysteine449.1NFKBIA, CARD16, REL, CFLAR, PTPRC, VIM
18threonine449.1PTPRC, REL, NFKBIA, TNFRSF8, TIA1, CFLAR
19retinoic acid44 249.9BCL6, REL, VIM, FUT4, CFLAR, NFKBIA
20oligonucleotide448.9REL, POU2F2, CFLAR, VIM, PAX5, NFKBIA
21paraffin448.4BCL6, PTPRC, PAX5, CD68, TNFRSF8, TIA1
22lipid448.1SWAP70, NFKBIA, CD68, CFLAR, PTPRC, TNFRSF8
23tyrosine446.4POU2AF1, BCL6, PTPRC, PAX5, CFLAR, REL

GO Terms for genes affiliated with Nodular Lymphocyte Predominant Hodgkin Lymphoma

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16Gene Ontology
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Biological processes related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.0CFLAR, TNFAIP3
2regulation of germinal center formationGO:0026349.8BCL6, TNFAIP3
3response to muramyl dipeptideGO:0324959.7NFKBIA, TNFAIP3
4apoptotic processGO:0069159.0NFKBIA, TNFAIP3, CFLAR, TIA1, VIM, PDCD1
5humoral immune responseGO:0069598.6PAX5, POU2AF1, POU2F2, PDCD1

Products for genes affiliated with Nodular Lymphocyte Predominant Hodgkin Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet
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