NLPHL
MCID: NDL021
MIFTS: 46

Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL) malady

Cancer diseases, Blood diseases, Rare diseases, Immune diseases categories

Summaries for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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MalaCards: Nodular Lymphocyte Predominant Hodgkin Lymphoma, also known as NLPHL, is related to diffuse large b-cell lymphoma and b-cell lymphomas, and has symptoms including asthenia/fatigue/weakness, fever/chilling and weight loss/loss of appetite/break in weight curve/general health alteration. An important gene associated with Nodular Lymphocyte Predominant Hodgkin Lymphoma is PDCD1 (programmed cell death 1), and among its related pathways are Development Glucocorticoid receptor signaling and B Cell Receptor Signaling Pathway. The compounds cytidine and rituximab have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone marrow, and related mouse phenotypes are growth/size/body and cellular.

Aliases & Classifications for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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50Orphanet, 63UMLS, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

50
nodular lymphocyte predominant hodgkin lymphoma:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

nodular lymphocyte predominant hodgkin lymphoma 50 63
nlphl 50


External Ids:

ICD10 via Orphanet27 C81.1
SNOMED-CT via Orphanet60 118605002, 277608004, 70600005
UMLS via Orphanet64 C1334968, C2239290
ICD1026 C81.0

Related Diseases for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:



Diseases related to nodular lymphocyte predominant hodgkin lymphoma

Symptoms for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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50Orphanet
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Symptoms:

50 (show all 13)
  • asthenia/fatigue/weakness
  • fever/chilling
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • lymphoma
  • hyperhidrosis/increased sweating
  • pruritus/itching
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • anorexia
  • bone marrow failure/pancytopenia
  • neoplasms/tumors
  • lymphadenopathy/polyadenopathies

Drugs & Therapeutics for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Drug clinical trials:

Search ClinicalTrials for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Search NIH Clinical Center for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Search CenterWatch for Nodular Lymphocyte Predominant Hodgkin Lymphoma

Genetic Tests for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Anatomical Context for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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34MalaCards
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MalaCards organs/tissues related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

34
T cells, B cells, Bone marrow, Bone, Liver, Lymph node, Small intestine, Lung, Monocytes

Animal Models for Nodular Lymphocyte Predominant Hodgkin Lymphoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.7BCL6, REL, PAX5, POU2F2, POU2AF1
2MP:00053847.4POU2AF1, PAX5, REL, BCL6, PDCD1, SWAP70
3MP:00107687.1POU2AF1, POU2F2, PAX5, REL, BCL6, PDCD1
4MP:00053976.9SWAP70, POU2AF1, POU2F2, PAX5, REL, BCL6
5MP:00053876.9POU2AF1, POU2F2, PAX5, REL, BCL6, PDCD1

Publications for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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53PubMed
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Articles related to Nodular Lymphocyte Predominant Hodgkin Lymphoma:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
The prognostic impact of variant histology in nodular lymphocyte-predominant Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG). (24100447)
2013
2
High-dose chemotherapy and autologous stem cell transplantation for nodular lymphocyte-predominant Hodgkin lymphoma. (23507470)
2013
3
Nodular lymphocyte predominant hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma - endpoints of a spectrum of one disease? (24244368)
2013
4
Does functional imaging distinguish nodular lymphocyte-predominant hodgkin lymphoma from T-cell/histiocyte-rich large B-cell lymphoma? (23773450)
2013
5
Occurrence of nodular lymphocyte-predominant hodgkin lymphoma in hermansky-pudlak type 2 syndrome is associated to natural killer and natural killer T cell defects. (24302998)
2013
6
VII. Management of nodular lymphocyte-predominant Hodgkin lymphoma. (23775649)
2013
7
High familial risk in nodular lymphocyte-predominant Hodgkin lymphoma. (23284040)
2013
8
How I treat nodular lymphocyte predominant Hodgkin lymphoma. (24215035)
2013
9
Primary nodular lymphocyte predominant Hodgkin lymphoma of the palate: a rare incidence which was also associated with progressive transformation of germinal centres of cervical lymph node. (23932753)
2013
10
Does "in situ lymphoma" occur as a distinct step in the development of nodular lymphocyte-predominant Hodgkin lymphoma? (21732334)
2012
11
The unique entity of nodular lymphocyte-predominant Hodgkin lymphoma: current approaches to diagnosis and management. (21812538)
2012
12
"Intrafollicular neoplasia" of nodular lymphocyte predominant Hodgkin lymphoma: description of a hypothetic early step of the disease. (22209342)
2012
13
Peripheral blood lymphocyte/monocyte ratio at diagnosis and survival in nodular lymphocyte-predominant Hodgkin lymphoma. (22360654)
2012
14
Nodular lymphocyte-predominant hodgkin lymphoma with atypical T cells: a morphologic variant mimicking peripheral T-cell lymphoma. (21997687)
2011
15
Mycobacterium avium intracellulare infection coexistent with nodular lymphocyte predominant Hodgkin lymphoma involving the lung. (21399527)
2011
16
Coexisting and clonally identical classic hodgkin lymphoma and nodular lymphocyte predominant hodgkin lymphoma. (21490448)
2011
17
Nodular lymphocyte predominant Hodgkin lymphoma behaves as a distinct clinical entity with good outcome: evidence from 14-year follow-up in the West of Scotland Cancer Network. (21663507)
2011
18
Analysis of KLHDC8B in familial nodular lymphocyte predominant Hodgkin lymphoma. (21517803)
2011
19
Nodular, lymphocyte-predominant Hodgkin lymphoma: a long-term study and analysis of transformation to diffuse large B-cell lymphoma in a cohort of 164 patients from the Adult Lymphoma Study Group. (20029973)
2010
20
Programmed death 1 expression in variant immunoarchitectural patterns of nodular lymphocyte predominant Hodgkin lymphoma: comparison with CD57 and lymphomas in the differential diagnosis. (20825974)
2010
21
Nodular lymphocyte predominant Hodgkin lymphoma: diagnostic pearls and pitfalls. (20923296)
2010
22
Nodular lymphocyte-predominant Hodgkin lymphoma and T cell histiocyte-rich large B cell lymphoma: diagnosis in two monozygotic twins. (20653789)
2010
23
Concurrent occurrence of nodular lymphocyte predominant Hodgkin lymphoma and Kaposi sarcoma in lymph nodes: a first case report. (20595178)
2010
24
Febrile cholestatic disease as an initial presentation of nodular lymphocyte-predominant Hodgkin lymphoma. (20845519)
2010
25
Nodular lymphocyte predominant Hodgkin lymphoma with clusters of LP Cells, acute inflammation, and fibrosis: a syncytial variant. (19730363)
2009
26
The emerging role for rituximab in the treatment of nodular lymphocyte predominant Hodgkin lymphoma. (19606035)
2009
27
Nodular lymphocyte predominant Hodgkin lymphoma. (19605845)
2009
28
Paraneoplastic lumbosacral axonal polyradiculopathy preceding the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma: a case report. (18720211)
2008
29
Beyond the lymphocyte predominant cell: CD4+CD8+ T-cells in nodular lymphocyte predominant Hodgkin lymphoma. (18949610)
2008
30
Refractory nodular lymphocyte predominant Hodgkin lymphoma transformed to T-cell/histiocyte-rich B-cell lymphoma in an adolescent: salvage therapy with allogeneic bone marrow transplantation. (19131792)
2008
31
Nodular lymphocyte-predominant Hodgkin lymphoma presenting as fulminant hepatic failure in a pediatric patient: a case report with pathologic, immunophenotypic, and molecular findings. (18227720)
2008
32
Nodular lymphocyte predominant Hodgkin lymphoma at atypical locations may be associated with increased numbers of large cells and a diffuse histologic component. (17918256)
2008
33
PD-1, a follicular T-cell marker useful for recognizing nodular lymphocyte-predominant Hodgkin lymphoma. (18594468)
2008
34
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL)-clinicopathological features based on the data of two Hungarian lymphoma centres. (18431694)
2008
35
Outcome of children with nodular lymphocyte predominant Hodgkin lymphoma - a Children's Cancer and Leukaemia Group report. (17760808)
2007
36
Bilateral proptosis as the initial presentation of systemic nodular lymphocyte predominant Hodgkin lymphoma. (17613778)
2007
37
Nodular lymphocyte-predominant hodgkin lymphoma. (17591565)
2007
38
Anti-CD20 monoclonal antibody (rituximab) for therapy of CD20-positive nodular lymphocyte-predominant Hodgkin lymphoma in an 10-year-old girl. (17065142)
2006
39
IgD positive L&H cells identify a unique subset of nodular lymphocyte predominant Hodgkin lymphoma. (16699312)
2006
40
A double-positive CD4+CD8+ T-cell population is commonly found in nodular lymphocyte predominant Hodgkin lymphoma. (17050078)
2006
41
Familial nodular lymphocyte predominant Hodgkin lymphoma: Successful treatment with CHOP plus rituximab. (16236615)
2005
42
Differential expression patterns of c-REL protein in classic and nodular lymphocyte predominant Hodgkin lymphoma. (15551733)
2004
43
Nodular lymphocyte predominant Hodgkin lymphoma in siblings. (15160926)
2004
44
Bone marrow involvement in patients with nodular lymphocyte predominant Hodgkin lymphoma. (15087668)
2004
45
Expression of c-FLIP in classic and nodular lymphocyte-predominant Hodgkin lymphoma. (15354734)
2004
46
Diffuse large B-cell lymphoma arising in nodular lymphocyte predominant Hodgkin lymphoma: a report of 21 cases from the Nebraska Lymphoma Study Group. (15370206)
2004
47
Diffuse large B-cell lymphoma arising in nodular lymphocyte predominant hodgkin lymphoma. A report of 21 cases from the Nebraska Lymphoma Study Group. (14738141)
2003
48
Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation. (14508396)
2003
49
Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma. (12393409)
2003
50
Nodular lymphocyte-predominant Hodgkin lymphoma with nodules resembling T-cell/histiocyte-rich B-cell lymphoma: differential diagnosis between nodular lymphocyte-predominant Hodgkin lymphoma and T-cell/histiocyte-rich B-cell lymphoma. (12881319)
2003

Variations for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Expression for genes affiliated with Nodular Lymphocyte Predominant Hodgkin Lymphoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nodular Lymphocyte Predominant Hodgkin Lymphoma

Search GEO for disease gene expression data for Nodular Lymphocyte Predominant Hodgkin Lymphoma.

Pathways for genes affiliated with Nodular Lymphocyte Predominant Hodgkin Lymphoma

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51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 5Cell Signaling Technology, 31KEGG
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Pathways related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5POU2F2, REL
29.3BCL6, REL
39.2BCL6, PAX5
4
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.1PDCD1, REL, POU2F2
58.9BCL6, REL, PAX5

Compounds for genes affiliated with Nodular Lymphocyte Predominant Hodgkin Lymphoma

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46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB
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Compounds related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cytidine46 25 1211.3BCL6, PAX5
2rituximab46 52 1211.2PAX5, BCL6
3zinc46 259.9BCL6, REL, PAX5
4oligonucleotide468.8POU2F2, PAX5, REL
5serine468.1BCL6, REL, PAX5, POU2F2
6tyrosine467.0SWAP70, POU2AF1, POU2F2, PAX5, REL, BCL6

GO Terms for genes affiliated with Nodular Lymphocyte Predominant Hodgkin Lymphoma

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17Gene Ontology
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Cellular components related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056347.1SWAP70, BCL6, MUM1, PAX5, POU2F2, POU2AF1

Biological processes related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription from RNA polymerase II promoterGO:0063668.9PAX5, POU2F2, POU2AF1
2humoral immune responseGO:0069598.3PDCD1, PAX5, POU2F2, POU2AF1

Molecular functions related to Nodular Lymphocyte Predominant Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435658.7BCL6, REL, POU2F2
2sequence-specific DNA binding transcription factor activityGO:0037007.9BCL6, REL, PAX5, POU2F2

Products for genes affiliated with Nodular Lymphocyte Predominant Hodgkin Lymphoma

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Sources for Nodular Lymphocyte Predominant Hodgkin Lymphoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet