Nodular Malignant Melanoma malady

MalaCards: Nodular Malignant Melanoma, also known as nodular melanoma (morphologic abnormality), is related to superficial spreading melanoma and cutaneous malignant melanoma. An important gene associated with Nodular Malignant Melanoma is IFNA8 (interferon, alpha 8), and among its related pathways are Renal cell carcinoma and Bladder cancer. The compounds delta 7-pga1 and hrgbeta1 have been mentioned in the context of this disorder. Affiliated tissues include skin and endothelial, and related mouse phenotypes are limbs/digits/tail and skeleton.

Aliases & Descriptions:

nodular malignant melanoma 6 8 nodular melanoma (morphologic abnormality) 6

nodular melanoma 43

Diseases related to nodular malignant melanoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 117)

id	Related Disease	Score	Top Affiliating Genes
1	superficial spreading melanoma	29.6	MYC, CDKN1A
2	cutaneous malignant melanoma	27.2	MYC, CDKN1A, VEGFA
3	melanoma	27.0	CDKN1A, MYC, EPAS1, NMS, SOX10, TYMP
4	chronic myocardial ischemia	13.0	TYMP, VEGFA
5	maxillary sinus squamous cell carcinoma	12.9	CDKN1A, VEGFA
6	extramedullary plasmacytoma	12.8	VEGFA, CDKN1A
7	neurofibroma	12.7	SOX10, TYMP, VEGFA
8	acute mountain sickness	12.7	HIF1A, VEGFA
9	pilocytic astrocytoma	12.6	SOX10, CDKN1A, VEGFA
10	bile duct cancer	12.5	TYMP, VEGFA, CDKN1A
11	cystadenocarcinoma	12.5	VEGFA, CDKN1A, TYMP
12	paraganglioma	12.5	EPAS1, TYMP, HIF1A
13	retinopathy of prematurity	12.5	EPAS1, VEGFA, HIF1A
14	von hippel-lindau disease	12.5	EPAS1, VEGFA, HIF1A
15	serous cystadenocarcinoma	12.4	CDKN1A, VEGFA
16	retinal ischemia	12.4	VEGFA, HIF1A
17	kidney cancer	12.4	HIF1A, TYMP, VEGFA
18	myxoma	12.4	VEGFA, TYMP, HIF1A
19	lymphoblastic lymphoma	12.3	CDKN1A, FGFR1OP, MYC
20	cervical intraepithelial neoplasia	12.3	CDKN1A, TYMP, VEGFA
21	malignant fibrous histiocytoma	12.3	TYMP, HIF1A, VEGFA
22	adenomyosis	12.2	VEGFA, CDKN1A, HIF1A
23	cholesteatoma	12.2	CDKN1A, HIF1A, VEGFA
24	fibrous histiocytoma	12.2	VEGFA, TYMP, HIF1A
25	histiocytoma	12.2	VEGFA, TYMP, HIF1A
26	glioblastoma	12.2	CDKN1A, HIF1A, VEGFA
27	pulmonary hypertension	12.1	EPAS1, HIF1A, ALDH7A1, VEGFA
28	polycythemia	12.1	HIF1A, VEGFA, EPAS1
29	primary effusion lymphoma	12.1	VEGFA, MYC, CDKN1A
30	plasmacytoma	12.1	CDKN1A, VEGFA, MYC
31	urinary bladder cancer	12.1	EPAS1, CDKN1A, VEGFA, TYMP
32	angiofibroma	12.0	HIF1A, MYC, VEGFA
33	breast cancer	12.0	MYC, TYMP, EPAS1
34	acute lymphocytic leukemia	12.0	VEGFA, CDKN1A, MYC
35	gastric adenocarcinoma	12.0	MYC, TYMP, HIF1A
36	giant cell tumor	12.0	CDKN1A, VEGFA, MYC
37	angiosarcoma	12.0	MYC, VEGFA, HIF1A
38	leiomyosarcoma	11.9	TYMP, VEGFA, MYC
39	chondrosarcoma	11.9	CDKN1A, VEGFA, EPAS1, HIF1A
40	renal cell carcinoma	11.9	EPAS1, TYMP, HIF1A, VEGFA
41	monocytic leukemia	11.9	VEGFA, CDKN1A, MYC
42	ductal carcinoma in situ	11.9	HIF1A, CDKN1A, VEGFA, TYMP
43	lung adenocarcinoma	11.9	TYMP, VEGFA, CDKN1A, HIF1A
44	adenomatous polyposis coli	11.8	CDKN1A, HIF1A, MYC
45	rectal cloacogenic carcinoma	11.8	VEGFA, HIF1A, TYMP, CDKN1A
46	papillary thyroid carcinoma	11.8	VEGFA, HIF1A, TYMP, CDKN1A
47	stomach carcinoma	11.7	MYC, VEGFA, TYMP, CDKN1A
48	soft tissue sarcoma	11.7	CDKN1A, TYMP, MYC, VEGFA
49	squamous cell carcinoma of the head and neck	11.6	TYMP, CDKN1A, MYC, VEGFA
50	cholestasis	11.6	EPAS1, HIF1A, MYC, VEGFA

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to nodular malignant melanoma:

²²

MGI Mouse Phenotypes related to nodular malignant melanoma:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail phenotype	MP:0005371	7.4	VEGFA, MYC, CDKN1A, HIF1A, SOX10
2	skeleton phenotype	MP:0005390	7.1	TYMP, HIF1A, CDKN1A, MYC, VEGFA, EPAS1

Articles related to nodular malignant melanoma:

id	Title	Authors	Year	Affiliating Genes
1	SOX10 expression in superficial spreading and nodular malignant melanomas. (20890226)	AgnarsdA^ttir M.... Hedstrand H.	2010	SOX10
2	Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. (14512791)	Giatromanolaki A.... Koukourakis M.I.	2003	VEGFA, HIF1A, EPAS1
3	c-MYC and nodular malignant melanoma. A case report. (10897006)	Greulich K.M.... KrAohn G.	2000	MYC, CDKN1A

Genes related to nodular malignant melanoma according to GeneCards:

(show all 14)

id	Symbol	Description	Score	GeneCards Section Context
1	IFNA8	interferon, alpha 8	11.0
2	NMS	neuromedin S	11.0
3	SOX10	SRY (sex determining region Y)-box 10	11.0	Publications
4	DIS3	DIS3 mitotic control homolog (S. cerevisiae)	11.0	Disorders
5	SEC23IP	SEC23 interacting protein	11.0
6	ALDH7A1	aldehyde dehydrogenase 7 family, member A1	11.0
7	FGFR1OP	FGFR1 oncogene partner	11.0
8	G3BP2	GTPase activating protein (SH3 domain) binding protein 2	11.0
9	EPAS1	endothelial PAS domain protein 1	11.0	Publications
10	TYMP	thymidine phosphorylase	11.0	Publications
11	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
12	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
13	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
14	VEGFA	vascular endothelial growth factor A	11.0	Publications

Pathways related to nodular malignant melanoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Renal cell carcinoma20	8.7	VEGFA, HIF1A, EPAS1
2	Bladder cancer20	8.3	VEGFA, MYC, CDKN1A, TYMP
3	Pathways in cancer20	7.3	EPAS1, HIF1A, CDKN1A, MYC, VEGFA

Compounds related to nodular malignant melanoma according to GeneDecks:

(show all 45)

id	Compound	Score	Top Affiliating Genes
1	delta 7-pga132	9.8	CDKN1A, MYC
2	hrgbeta132	9.7	MYC, CDKN1A
3	everolimus32 9 9	11.7	MYC, VEGFA
4	pga232	9.7	MYC, CDKN1A
5	10-hydroxycamptothecin32	9.7	MYC, CDKN1A
6	capecitabine32 34 9 9	12.6	TYMP, VEGFA
7	tomudex32	9.6	CDKN1A, TYMP
8	mezerein32	9.6	MYC, CDKN1A
9	doxorubicin32 34 9 9	12.6	HIF1A, TYMP
10	3-(5-hydroxymethyl-2-furyl)-1-benzylindazole32	9.5	VEGFA, HIF1A
11	3,3-diindolylmethane32	9.3	VEGFA, CDKN1A
12	su541632	9.3	VEGFA, HIF1A
13	taxane32	9.3	VEGFA, CDKN1A, TYMP
14	oxaliplatin32 34 9 9	12.3	VEGFA, CDKN1A, TYMP
15	mithramycin32	9.2	CDKN1A, MYC, VEGFA
16	15-deoxy-delta-12,14-prostaglandin j232	9.2	CDKN1A, MYC, VEGFA
17	thymidylate32	9.1	VEGFA, CDKN1A, TYMP
18	flavopiridol32 9 9	10.9	VEGFA, CDKN1A, HIF1A
19	celecoxib32 42 34 9 18 9	13.9	VEGFA, CDKN1A, HIF1A
20	cobalt chloride32	8.8	VEGFA, HIF1A
21	geldanamycin32 9 9	10.8	HIF1A, CDKN1A, VEGFA
22	lactacystin32	8.8	MYC, CDKN1A, HIF1A
23	resveratrol32 9 18 9	11.6	VEGFA, CDKN1A, HIF1A
24	adriamycin32	8.5	HIF1A, CDKN1A, MYC
25	irinotecan32 34 9 9	11.5	TYMP, HIF1A, CDKN1A, VEGFA
26	5fluorouracil32	8.4	TYMP, HIF1A, CDKN1A, VEGFA
27	bortezomib32 9 9	10.4	VEGFA, MYC, CDKN1A, HIF1A
28	camptothecin32 42 9 9	11.4	MYC, CDKN1A, HIF1A
29	mg 13232 42	9.4	HIF1A, CDKN1A, MYC, VEGFA
30	arsenite32 18	9.4	HIF1A, CDKN1A, MYC, VEGFA
31	pd 98,05932	8.4	EPAS1, HIF1A, CDKN1A, MYC
32	n acetylcysteine32	8.3	HIF1A, CDKN1A, MYC, VEGFA
33	rapamycin32 42	9.3	VEGFA, MYC, CDKN1A, HIF1A
34	genistein32 9 18 9	11.1	VEGFA, MYC, CDKN1A, HIF1A
35	docetaxel32 34 9 9	11.0	VEGFA, MYC, CDKN1A, HIF1A, TYMP
36	gemcitabine32 34 9 9	11.0	TYMP, HIF1A, CDKN1A, MYC, VEGFA
37	tamoxifen32 34 9 9	11.0	VEGFA, MYC, CDKN1A, HIF1A, TYMP
38	paclitaxel32 34 9 9	11.0	TYMP, HIF1A, CDKN1A, MYC, VEGFA
39	ly29400232	7.9	TYMP, HIF1A, CDKN1A, MYC, VEGFA
40	actinomycin d32	7.9	VEGFA, MYC, CDKN1A, HIF1A, TYMP
41	paraffin32	7.9	TYMP, HIF1A, CDKN1A, MYC, VEGFA
42	cisplatin32 34 9 9	10.9	TYMP, HIF1A, CDKN1A, MYC, VEGFA
43	cycloheximide32	7.9	TYMP, HIF1A, CDKN1A, MYC, VEGFA
44	vegf32	7.5	EPAS1, TYMP, HIF1A, CDKN1A, MYC, VEGFA
45	tyrosine32	7.1	EPAS1, TYMP, HIF1A, CDKN1A, MYC, VEGFA

Cellular components related to nodular malignant melanoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	6.8	CDKN1A, FGFR1OP, ALDH7A1, DIS3, G3BP2, HIF1A

Biological processes related to nodular malignant melanoma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO:043619	9.4	HIF1A, EPAS1
2	positive regulation of neuroblast proliferation	GO:002052	9.4	SOX10, HIF1A
3	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061419	9.4	VEGFA, HIF1A
4	embryonic placenta development	GO:001892	9.2	HIF1A, EPAS1
5	digestive tract morphogenesis	GO:048546	9.1	HIF1A, SOX10
6	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:030949	9.0	VEGFA, HIF1A
7	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061418	9.0	VEGFA, HIF1A, EPAS1
8	cellular response to stress	GO:033554	9.0	EPAS1, HIF1A, VEGFA
9	cellular response to hypoxia	GO:071456	8.9	VEGFA, HIF1A, EPAS1
10	negative regulation of apoptotic process	GO:043066	8.7	SOX10, CDKN1A, MYC, VEGFA
11	angiogenesis	GO:001525	8.5	EPAS1, TYMP, HIF1A, VEGFA
12	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.0	VEGFA, MYC, HIF1A, SOX10, EPAS1

Molecular functions related to nodular malignant melanoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	histone acetyltransferase binding	GO:035035	9.2	HIF1A, EPAS1
2	platelet-derived growth factor receptor binding	GO:005161	9.2	VEGFA, TYMP
3	protein heterodimerization activity	GO:046982	8.1	VEGFA, MYC, HIF1A, EPAS1