MCID: NDL001
MIFTS: 46

Nodular Malignant Melanoma malady

Rare diseases, Cancer diseases categories

Summaries for Nodular Malignant Melanoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

MalaCards: Nodular Malignant Melanoma, also known as nodular melanoma, is related to melanoma and spitz nevus. An important gene associated with Nodular Malignant Melanoma is SOX10 (SRY (sex determining region Y)-box 10), and among its related pathways are Notch signaling pathway and TP53 network. The compounds delta 7-pga1 and hrgbeta1 have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and endothelial, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Aliases & Classifications for Nodular Malignant Melanoma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 63UMLS, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

nodular malignant melanoma 9 11
nodular melanoma 9 44 63


External Ids:

Disease Ontology9 DOID:10047
SNOMED-CT59 2142002, 254731001
NCIt41 C4225

Related Diseases for Nodular Malignant Melanoma

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18GeneCards, 19GeneDecks
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Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma30.9VEGFA, HIF1A, SOX10, MYC, CDKN1A
2spitz nevus10.3
3superficial spreading melanoma10.3
4lentigo maligna melanoma10.2
5eccrine acrospiroma10.2
6nodular hidradenoma10.2
7hidradenoma10.2
8psoriasis10.2
9acrospiroma10.2
10hypoxia10.2
11endotheliitis10.2
12leukodystrophy10.1TYMP, SOX10
13erythrocytosis10.1HIF1A
14cervical squamous cell carcinoma10.0CDKN1A, TYMP
15rectal neoplasm10.0TYMP, CDKN1A
16acral lentiginous melanoma10.0
17keratoacanthoma10.0
18cutaneous malignant melanoma10.0
19anaplastic astrocytoma10.0TYMP, VEGFA
20laryngeal squamous cell carcinoma10.0VEGFA, CDKN1A
21oligodendroglioma10.0SOX10, CDKN1A
22retinal ischemia10.0VEGFA, HIF1A
23kidney cancer10.0VEGFA, EPAS1
24hemangioblastoma10.0VEGFA, HIF1A
25von hippel-lindau disease10.0HIF1A, VEGFA
26proliferative diabetic retinopathy10.0VEGFA, HIF1A
27breast cancer10.0MYC, EPAS1, TYMP
28renal clear cell carcinoma10.0VEGFA, HIF1A
29bladder carcinoma10.0CDKN1A, TYMP
30kidney rhabdoid cancer10.0HIF1A, VEGFA, TYMP
31diabetic retinopathy10.0HIF1A, VEGFA
32lung cancer10.0VEGFA, CDKN1A, MYC
33myeloma10.0VEGFA, CDKN1A, MYC
34gastric adenocarcinoma10.0MYC, TYMP, HIF1A
35glioblastoma multiforme10.0VEGFA, HIF1A, CDKN1A
36malignant glioma9.9HIF1A, VEGFA, CDKN1A
37prostate cancer9.9CDKN1A, HIF1A, MYC
38osteosarcoma9.9HIF1A, CDKN1A, MYC
39lung adenocarcinoma9.9TYMP, VEGFA, HIF1A, CDKN1A
40astrocytoma9.9HIF1A, VEGFA, TYMP, CDKN1A
41pancreatic cancer9.9HIF1A, VEGFA, CDKN1A, TYMP
42cervical cancer9.9MYC, HIF1A, TYMP, CDKN1A
43squamous cell carcinoma of the head and neck9.9CDKN1A, MYC, HIF1A, VEGFA, TYMP
44endometrial carcinoma9.9MYC, CDKN1A, HIF1A, VEGFA, TYMP
45non-small cell lung carcinoma9.9MYC, CDKN1A, VEGFA, TYMP, HIF1A
46stomach cancer9.9VEGFA, HIF1A, TYMP, MYC, CDKN1A
47ovarian cancer9.9CDKN1A, TYMP, VEGFA, HIF1A, MYC
48colon cancer9.9MYC, VEGFA, TYMP, HIF1A, CDKN1A
49colorectal cancer9.8MYC, VEGFA, TYMP, CDKN1A, HIF1A
50tongue squamous cell carcinoma9.8CDKN1A, HIF1A, VEGFA, TYMP, MYC

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to nodular malignant melanoma

Symptoms for Nodular Malignant Melanoma

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Drugs & Therapeutics for Nodular Malignant Melanoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Nodular Malignant Melanoma

Drug clinical trials:

Search ClinicalTrials for Nodular Malignant Melanoma

Search NIH Clinical Center for Nodular Malignant Melanoma

Search CenterWatch for Nodular Malignant Melanoma

Genetic Tests for Nodular Malignant Melanoma

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Anatomical Context for Nodular Malignant Melanoma

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34MalaCards
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MalaCards organs/tissues related to Nodular Malignant Melanoma:

34
Skin, Lymph node, Endothelial

Animal Models for Nodular Malignant Melanoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Nodular Malignant Melanoma:

38 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7VEGFA, HIF1A, SOX10, MYC, CDKN1A
2MP:00053888.7VEGFA, HIF1A, SOX10, EPAS1, CDKN1A
3MP:00020068.7VEGFA, HIF1A, SOX10, MYC, CDKN1A
4MP:00053828.7CDKN1A, MYC, SOX10, HIF1A, VEGFA
5MP:00053708.6VEGFA, HIF1A, EPAS1, MYC, CDKN1A
6MP:00053818.6VEGFA, HIF1A, SOX10, MYC, CDKN1A
7MP:00053698.6VEGFA, HIF1A, EPAS1, MYC, CDKN1A
8MP:00053798.5VEGFA, HIF1A, SOX10, MYC, CDKN1A
9MP:00107718.5VEGFA, HIF1A, SOX10, MYC, CDKN1A
10MP:00053808.4VEGFA, HIF1A, SOX10, EPAS1, MYC, CDKN1A
11MP:00053908.4CDKN1A, MYC, EPAS1, HIF1A, VEGFA, TYMP
12MP:00030128.3CDKN1A, MYC, SEC23IP, VEGFA
13MP:00053878.2TYMP, VEGFA, HIF1A, EPAS1, MYC, CDKN1A
14MP:00053848.1TYMP, VEGFA, HIF1A, SOX10, MYC, CDKN1A
15MP:00053858.1VEGFA, HIF1A, EPAS1, MYC, CDKN1A
16MP:00036318.0TYMP, VEGFA, HIF1A, SOX10, EPAS1, MYC
17MP:00053768.0TYMP, VEGFA, HIF1A, SOX10, EPAS1, MYC
18MP:00053788.0VEGFA, HIF1A, SOX10, EPAS1, MYC, CDKN1A
19MP:00107687.7G3BP2, VEGFA, HIF1A, SOX10, EPAS1, MYC

Publications for Nodular Malignant Melanoma

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53PubMed
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Articles related to Nodular Malignant Melanoma:

(show all 15)
idTitleAuthorsYear
1
SOX10 expression in superficial spreading and nodular malignant melanomas. (20890226)
2010
2
Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. (21390477)
2010
3
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. (19550360)
2009
4
Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. (18319032)
2008
5
Nodular malignant melanoma with Spitz nevus-like pathological features finally confirmed by the pathological feature of the sentinel lymph node. (18078408)
2007
6
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. (14512791)
2003
7
c-MYC and nodular malignant melanoma. A case report. (10897006)
2000
8
Nodular malignant melanoma - Secondary to carcinoma rectum. (20944369)
1997
9
Nodular malignant melanoma. (1597831)
1992
10
Factor XIIIa in nodular malignant melanoma and Spitz naevi. (1979912)
1990
11
A comparative study of Spitz nevus and nodular malignant melanoma using image analysis cytometry. (3295064)
1987
12
Nodular malignant melanoma of upper eyelid. (6470506)
1984
13
Nodular malignant melanoma and multiple squamous cell carcinomas in a patient treated by photochemotherapy for psoriasis. (6439287)
1984
14
Nodular malignant melanoma: a distinct entity or a common end stage? (7149203)
1982
15
Clinical differentiation of adult-onset cavernous angioma from nodular malignant melanoma. (7369746)
1980

Variations for Nodular Malignant Melanoma

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Expression for genes affiliated with Nodular Malignant Melanoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nodular Malignant Melanoma

Search GEO for disease gene expression data for Nodular Malignant Melanoma.

Pathways for genes affiliated with Nodular Malignant Melanoma

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters, 52PharmGKB, 5Cell Signaling Technology, 54QIAGEN
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Pathways related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Notch signaling pathway39
9.7CDKN1A, MYC
2
Show member pathways
9.7CDKN1A, MYC
39.7CDKN1A, MYC
49.7CDKN1A, MYC
59.6MYC, HIF1A
69.6EPAS1, VEGFA
79.6VEGFA, CDKN1A
89.6CDKN1A, VEGFA
9
Show member pathways
9.5HIF1A, VEGFA
109.5HIF1A, VEGFA
11
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway61
9.5HIF1A, VEGFA
12
Show member pathways
Angiogenesis39
9.5HIF1A, VEGFA
13
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.3EPAS1, MYC, CDKN1A
149.3CDKN1A, EPAS1, HIF1A
159.2VEGFA, MYC, CDKN1A
169.2VEGFA, MYC, CDKN1A
17
Show member pathways
9.2CDKN1A, MYC, VEGFA
189.2CDKN1A, MYC, VEGFA
19
Show member pathways
9.2VEGFA, HIF1A, EPAS1
20
Show member pathways
VEGFR1 specific signals39
9.2EPAS1, HIF1A, VEGFA
219.2VEGFA, HIF1A, EPAS1
229.1VEGFA, HIF1A, CDKN1A
23
Show member pathways
8.9HIF1A, SOX10, MYC, CDKN1A
24
Show member pathways
Signaling Pathways in Glioblastoma39
8.9TYMP, VEGFA, MYC, CDKN1A
25
Show member pathways
8.8CDKN1A, EPAS1, HIF1A, VEGFA
268.7VEGFA, HIF1A, MYC, CDKN1A
278.4CDKN1A, MYC, EPAS1, HIF1A, VEGFA
28
Show member pathways
8.1VEGFA, HIF1A, MYC, NMS, CDKN1A

Compounds for genes affiliated with Nodular Malignant Melanoma

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1delta 7-pga14610.1MYC, CDKN1A
2hrgbeta14610.0MYC, CDKN1A
3pga24610.0MYC, CDKN1A
43-(5-hydroxymethyl-2-furyl)-1-benzylindazole469.9HIF1A, VEGFA
510-hydroxycamptothecin469.9CDKN1A, MYC
6tomudex469.8TYMP, CDKN1A
7mezerein469.8CDKN1A, MYC
8taxane469.7VEGFA, CDKN1A, TYMP
9oxaliplatin46 52 1211.6TYMP, VEGFA, CDKN1A
10mithramycin469.6CDKN1A, MYC, VEGFA
11vincristine46 52 1211.5TYMP, MYC, HIF1A
12carboplatin46 52 1211.5VEGFA, HIF1A, SOX10
13thymidylate469.5VEGFA, TYMP, CDKN1A
14lactacystin469.5CDKN1A, HIF1A, MYC
1515-deoxy-delta-12,14-prostaglandin j2469.5CDKN1A, MYC, VEGFA
16ns 39846 6210.5CDKN1A, HIF1A, VEGFA
17everolimus46 52 1211.5VEGFA, HIF1A, MYC
18flavopiridol46 1210.5HIF1A, VEGFA, CDKN1A
19celecoxib46 62 30 52 25 1214.5CDKN1A, VEGFA, HIF1A
20adriamycin469.4HIF1A, CDKN1A, MYC
21geldanamycin46 52 62 1212.4CDKN1A, VEGFA, HIF1A
22camptothecin46 62 1211.4HIF1A, MYC, CDKN1A
23resveratrol46 62 25 1212.3HIF1A, CDKN1A, VEGFA
24irinotecan46 52 1211.2CDKN1A, HIF1A, VEGFA, TYMP
25pd 98,059469.2MYC, CDKN1A, HIF1A, EPAS1
26egcg469.2CDKN1A, HIF1A, VEGFA
27su5416469.2HIF1A, VEGFA
285fluorouracil469.2HIF1A, CDKN1A, TYMP, VEGFA
29cyclophosphamide46 52 1211.2VEGFA, HIF1A, TYMP
30bortezomib46 52 1211.2VEGFA, MYC, CDKN1A, HIF1A
31thymidine46 2510.2CDKN1A, MYC, HIF1A, TYMP
32mg 13246 6210.1VEGFA, HIF1A, CDKN1A, MYC
33arsenite46 2510.1CDKN1A, MYC, HIF1A, VEGFA
34n acetylcysteine469.1VEGFA, CDKN1A, MYC, HIF1A
35rapamycin469.1VEGFA, HIF1A, MYC, CDKN1A
36imatinib46 52 1211.1CDKN1A, VEGFA, MYC
37genistein46 30 62 3 25 1214.0VEGFA, HIF1A, MYC, CDKN1A
38gemcitabine46 52 1210.8VEGFA, TYMP, HIF1A, MYC, CDKN1A
39tamoxifen46 52 30 1211.8VEGFA, HIF1A, MYC, TYMP, CDKN1A
40ly294002468.8CDKN1A, MYC, TYMP, VEGFA, HIF1A
41doxorubicin46 52 1210.8MYC, CDKN1A, HIF1A, VEGFA, TYMP
42actinomycin d468.8MYC, VEGFA, CDKN1A, TYMP, HIF1A
43paraffin468.8HIF1A, MYC, CDKN1A, VEGFA, TYMP
44cisplatin46 52 62 1211.8TYMP, CDKN1A, MYC, HIF1A, VEGFA
45cycloheximide468.8MYC, CDKN1A, HIF1A, VEGFA, TYMP
46estrogen468.7CDKN1A, MYC, HIF1A, VEGFA, TYMP
47docetaxel46 52 62 1211.5VEGFA, HIF1A, SOX10, MYC, CDKN1A, TYMP
48paclitaxel46 52 1210.5CDKN1A, MYC, SOX10, HIF1A, VEGFA, TYMP
49vegf468.5CDKN1A, EPAS1, HIF1A, VEGFA, MYC, TYMP
50tyrosine467.6TYMP, VEGFA, SEC23IP, MYC, EPAS1, HIF1A

GO Terms for genes affiliated with Nodular Malignant Melanoma

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17Gene Ontology
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Cellular components related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.9CDKN1A, MYC, EPAS1, HIF1A

Biological processes related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:04361910.0EPAS1, HIF1A
2digestive tract morphogenesisGO:04854610.0SOX10, HIF1A
3surfactant homeostasisGO:0431299.9VEGFA, EPAS1
4embryonic placenta developmentGO:0018929.9EPAS1, HIF1A
5neural crest cell migrationGO:0017559.9HIF1A, SOX10
6positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.8VEGFA, HIF1A
7dopaminergic neuron differentiationGO:0715429.8HIF1A, VEGFA
8positive regulation of fibroblast proliferationGO:0481469.8CDKN1A, MYC
9positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.8HIF1A, VEGFA
10positive regulation of mesenchymal cell proliferationGO:0020539.7MYC, VEGFA
11outflow tract morphogenesisGO:0031519.7VEGFA, HIF1A
12cell maturationGO:0484699.7VEGFA, SOX10, EPAS1
13lactationGO:0075959.6HIF1A, VEGFA
14regulation of gene expressionGO:0104689.6HIF1A, MYC
15positive regulation of neuroblast proliferationGO:0020529.6SOX10, HIF1A, VEGFA
16regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.5EPAS1, HIF1A, VEGFA
17positive regulation of endothelial cell proliferationGO:0019389.5HIF1A, VEGFA
18cellular response to hypoxiaGO:0714569.5EPAS1, HIF1A, VEGFA
19positive regulation of epithelial cell proliferationGO:0506799.4MYC, VEGFA
20response to hypoxiaGO:0016669.4VEGFA, HIF1A, EPAS1
21cellular iron ion homeostasisGO:0068799.3MYC, HIF1A
22angiogenesisGO:0015259.2EPAS1, HIF1A, VEGFA, TYMP
23negative regulation of apoptotic processGO:0430669.2CDKN1A, MYC, SOX10, VEGFA
24positive regulation of transcription from RNA polymerase II promoterGO:0459449.0VEGFA, HIF1A, EPAS1, MYC

Molecular functions related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor bindingGO:0051619.5TYMP, VEGFA
2histone acetyltransferase bindingGO:0350359.4EPAS1, HIF1A
3protein heterodimerization activityGO:0469829.2EPAS1, HIF1A, VEGFA
4transcription factor bindingGO:0081349.0MYC, EPAS1, SOX10, HIF1A

Products for genes affiliated with Nodular Malignant Melanoma

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Sources for Nodular Malignant Melanoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet