MCID: NDL001
MIFTS: 42

Nodular Malignant Melanoma

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Nodular Malignant Melanoma

MalaCards integrated aliases for Nodular Malignant Melanoma:

Name: Nodular Malignant Melanoma 12 14
Nodular Melanoma 12 49 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10047
NCIt 46 C4225
SNOMED-CT 64 2142002 254731001
UMLS 69 C0334424

Summaries for Nodular Malignant Melanoma

Disease Ontology : 12 A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.

MalaCards based summary : Nodular Malignant Melanoma, also known as nodular melanoma, is related to melanoma and herpetiform pemphigus. An important gene associated with Nodular Malignant Melanoma is XPR1 (Xenotropic And Polytropic Retrovirus Receptor 1), and among its related pathways/superpathways are Pathways in cancer and Degradation of the extracellular matrix. The drugs Ganciclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and lymph node, and related phenotypes are shRNA abundance <= 50% and homeostasis/metabolism

Wikipedia : 72 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

Related Diseases for Nodular Malignant Melanoma

Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 melanoma 10.4
2 herpetiform pemphigus 10.3 DSG1 DSG3
3 squamous cell carcinoma of the hypopharynx 10.2 MMP1 TIMP2
4 multicentric osteolysis, nodulosis, and arthropathy 10.2 MMP14 MMP2
5 winchester syndrome 10.2 MMP14 MMP2
6 spastic entropion 10.2 MMP1 MMP2
7 pulmonary emphysema 10.2 HMOX1 MMP1 TIMP2
8 bullous impetigo 10.2 DSG1 DSG3
9 light chain deposition disease 10.1 MMP1 MMP14 MMP2
10 pneumothorax 10.1 BLVRA HMOX1 MMP2
11 conjunctivochalasis 10.1 MMP1 MMP2 TIMP2
12 adenomyosis 10.1 MMP1 MMP2 TIMP2
13 inguinal hernia 10.1 MMP1 MMP2 TIMP2
14 serous cystadenocarcinoma 10.1 CDKN1A MMP14 MMP2
15 lymphangioleiomyomatosis 10.1 MMP1 MMP14 MMP2
16 varicose veins 10.0 MMP1 MMP2 TIMP2
17 fibromatosis, gingival, 1 10.0 MMP1 MMP2
18 internal hemorrhoid 9.9 MMP1 MMP2
19 actinic keratosis 9.9 CDKN2A MMP14 MMP2
20 nasal cavity squamous cell carcinoma 9.9 CDKN2A MMP2 TIMP2
21 aortic aneurysm, familial abdominal, 1 9.9 MMP1 MMP14 MMP2 TIMP2
22 spitz nevus 9.9
23 li-fraumeni syndrome 9.9 ATM CDKN1A CDKN2A
24 periodontal disease 9.9 MMP1 MMP2 TIMP2
25 tongue cancer 9.8 CDKN1A CDKN2A MMP2
26 skin melanoma 9.8 CDKN1A CDKN2A MMP2
27 gastrointestinal system cancer 9.8 CDKN1A CDKN2A MMP2
28 gallbladder cancer 9.8 CDKN2A MMP2 TIMP2
29 aging 9.7
30 squamous cell carcinoma 9.7
31 nodular hidradenoma 9.7
32 vaginitis 9.7
33 hidradenoma 9.7
34 pustulosis of palm and sole 9.7
35 eccrine acrospiroma 9.7
36 psoriasis 9.7
37 acrospiroma 9.7
38 hypoxia 9.7
39 endotheliitis 9.7
40 malignant glioma 9.7 CDKN1A CDKN2A MMP14 MMP2
41 oral squamous cell carcinoma 9.6 CDKN1A CDKN2A MMP1 MMP2
42 fibrosarcoma 9.6 CDKN1A MMP1 MMP14 MMP2 TIMP2
43 glioblastoma multiforme 9.6 CDKN1A CDKN2A MMP2 NES
44 conjunctival nevus 9.4 MMP2 WDFY2
45 bladder cancer 9.4 CDKN1A CDKN2A MMP1 MMP2 TIMP2
46 squamous cell carcinoma, head and neck 9.3 CDKN1A CDKN2A MMP1 MMP14 MMP2 TIMP2

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to Nodular Malignant Melanoma

Symptoms & Phenotypes for Nodular Malignant Melanoma

GenomeRNAi Phenotypes related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.32 ATM BLVRA CDKN1A DPP4 HMOX1 ITGB3

MGI Mouse Phenotypes related to Nodular Malignant Melanoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 CDKN1A CDKN2A DPP4 DSG3 HMOX1 HMOX2
2 immune system MP:0005387 10.11 XPR1 ATM CDKN1A CDKN2A DSG3 HMOX1
3 cardiovascular system MP:0005385 10.09 ATM CDKN1A CDKN2A HMOX1 HMOX2 ITGB3
4 adipose tissue MP:0005375 9.93 ATM CDKN1A DSG1 DSG3 HMOX1 MMP14
5 integument MP:0010771 9.92 ATM CDKN1A CDKN2A DSG1 DSG3 HMOX2
6 muscle MP:0005369 9.8 CDKN2A HMOX1 HMOX2 ITGB3 MMP14 MMP2
7 neoplasm MP:0002006 9.63 ATM CDKN1A CDKN2A ITGB3 MMP1 MMP2
8 respiratory system MP:0005388 9.56 CDKN1A CDKN2A DSG3 HMOX1 HMOX2 ITGB3
9 vision/eye MP:0005391 9.17 DSG3 ITGB3 MMP14 MMP2 CDKN1A CDKN2A

Drugs & Therapeutics for Nodular Malignant Melanoma

Drugs for Nodular Malignant Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
2 Anti-Infective Agents Phase 1
3 Antiviral Agents Phase 1
4 Ganciclovir triphosphate Phase 1
5 Nucleic Acid Synthesis Inhibitors Phase 1
6 tyrosine Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
2 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2 gamma-secretase/Notch signalling pathway inhibitor RO4929097
3 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1 ganciclovir
4 cKIT, BRAF/NRAS Mutations in Advanced Melanoma : Clinical Outcome in Response to Tyrosine-kinase Inhibitors - KitMel Project Completed NCT01543113
5 Study of Families With Melanoma Recruiting NCT00445783

Search NIH Clinical Center for Nodular Malignant Melanoma

Genetic Tests for Nodular Malignant Melanoma

Anatomical Context for Nodular Malignant Melanoma

MalaCards organs/tissues related to Nodular Malignant Melanoma:

38
Skin, Endothelial, Lymph Node

Publications for Nodular Malignant Melanoma

Articles related to Nodular Malignant Melanoma:

(show all 39)
# Title Authors Year
1
Nodular melanoma is less likely than superficial spreading melanoma to be histologically associated with a naevus. ( 29020904 )
2017
2
BRAF-V600E expression in primary nodular melanoma is associated with aggressive tumour features and reduced survival. ( 26924424 )
2016
3
Nodular melanoma in trophic ulceration of a leprosy patient: a case study. ( 27169340 )
2016
4
Rare nodular malignant melanoma of the heel in the Caribbean: A case report. ( 28012339 )
2016
5
Dermoscopy of Nodular Melanoma: Review of the Literature and Report of 3 Cases. ( 27663921 )
2016
6
Case of nodular melanoma on the upper eyelid dermoscopically mimicking pigmented basal cell carcinoma. ( 27649925 )
2016
7
An assessment of clinical pathways and missed opportunities for the diagnosis of nodular melanoma versus superficial spreading melanoma. ( 26563931 )
2015
8
Vaginal Amelanotic Nodular Malignant Melanoma in A Middle-Aged Female: A Rare Case Report and Review of Literature. ( 26085744 )
2015
9
BRAF and NRAS mutations are heterogeneous and not mutually exclusive in nodular melanoma. ( 24710085 )
2015
10
RSK1 activation promotes invasion in nodular melanoma. ( 25579842 )
2015
11
EGFR and cyclin D1 in nodular melanoma: correlation with pathohistological parameters and overall survival. ( 25304234 )
2014
12
Nodular malignant melanoma. Or maybe not? ( 24635092 )
2014
13
Nodular Melanoma Mimicking Keratoacanthoma: Lessons to learn. ( 22912931 )
2012
14
SOX10 expression in superficial spreading and nodular malignant melanomas. ( 20890226 )
2010
15
Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. ( 21390477 )
2010
16
Nestin is expressed in HMB-45 negative melanoma cells in dermal parts of nodular melanoma. ( 20536663 )
2010
17
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. ( 19550360 )
2009
18
TRPM1 (Melastatin-1/MLSN1) mRNA expression in Spitz nevi and nodular melanomas. ( 19396153 )
2009
19
Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. ( 18319032 )
2008
20
Nodular malignant melanoma with Spitz nevus-like pathological features finally confirmed by the pathological feature of the sentinel lymph node. ( 18078408 )
2007
21
Increased C-MYC copy numbers on the background of CDKN2A loss is associated with improved survival in nodular melanoma. ( 16977458 )
2007
22
BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival. ( 16098042 )
2005
23
Immunohistochemical study of melanocytic differentiation antigens in cutaneous malignant melanoma. A comparison of six commercial antibodies and one non-commercial antibody in nodular melanoma, superficially spreading melanoma and lentigo maligna melanoma. ( 15233017 )
2004
24
Extra copies of c-myc are more pronounced in nodular melanomas than in superficial spreading melanomas as revealed by fluorescence in situ hybridisation. ( 15221868 )
2004
25
Altered expression of cell cycle regulators Cyclin D1, p14, p16, CDK4 and Rb in nodular melanomas. ( 15547691 )
2004
26
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. ( 14512791 )
2003
27
c-MYC and nodular malignant melanoma. A case report. ( 10897006 )
2000
28
p53-protein and Ki-67-antigen expression are both reliable biomarkers of prognosis in thick stage I nodular melanomas of the skin. ( 9023558 )
1997
29
Nodular malignant melanoma - Secondary to carcinoma rectum. ( 20944369 )
1997
30
Digital occurrence of nodular malignant melanoma. ( 9110528 )
1997
31
Nodular malignant melanoma. ( 1597831 )
1992
32
Differential expression of melanoma associated antigens in acral lentiginous melanoma and in nodular melanoma lesions. ( 1671829 )
1991
33
Factor XIIIa in nodular malignant melanoma and Spitz naevi. ( 1979912 )
1990
34
A comparative study of Spitz nevus and nodular malignant melanoma using image analysis cytometry. ( 3295064 )
1987
35
Nodular malignant melanoma and multiple squamous cell carcinomas in a patient treated by photochemotherapy for psoriasis. ( 6439287 )
1984
36
Nodular malignant melanoma of upper eyelid. ( 6470506 )
1984
37
Nodular malignant melanoma: a distinct entity or a common end stage? ( 7149203 )
1982
38
Clinical differentiation of adult-onset cavernous angioma from nodular malignant melanoma. ( 7369746 )
1980
39
Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma. ( 50762 )
1975

Variations for Nodular Malignant Melanoma

Expression for Nodular Malignant Melanoma

Search GEO for disease gene expression data for Nodular Malignant Melanoma.

Pathways for Nodular Malignant Melanoma

Pathways related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1 12.67 CDKN1A CDKN2A HMOX1 MMP1 MMP2
2
Show member pathways
12.58 ITGB3 MMP1 MMP14 MMP2 TIMP2
3
Show member pathways
12.4 CDKN1A CDKN2A MMP1 MMP2
4 12.28 ATM CDKN1A CDKN2A HMOX1 ITGB3
5 12 CDKN1A MMP1 MMP14 MMP2
6 11.89 ATM CDKN1A CDKN2A MMP2
7 11.84 ITGB3 MMP14 MMP2
8 11.8 ATM CDKN1A CDKN2A
9 11.76 CDKN1A CDKN2A MMP14
10 11.73 CDKN1A HMOX1 MMP1 MMP2
11
Show member pathways
11.62 MMP1 MMP14 MMP2 TIMP2
12 11.58 ATM CDKN1A CDKN2A
13 11.4 HMOX1 ITGB3 MMP2 TIMP2
14 11.38 CDKN1A CDKN2A MMP2
15 11.3 ATM CDKN1A MMP1
16 11.14 HMOX1 MMP1 MMP2
17 11.12 CDKN1A CDKN2A MMP1 MMP2
18 10.91 MMP1 MMP2
19
Show member pathways
10.78 ATM CDKN1A CDKN2A
20 10.71 MMP1 MMP14 MMP2 TIMP2

GO Terms for Nodular Malignant Melanoma

Cellular components related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.1 DSG1 MMP1 MMP14 MMP2 NES TIMP2

Biological processes related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 9.58 DPP4 ITGB3 XPR1
2 extracellular matrix disassembly GO:0022617 9.56 MMP1 MMP14 MMP2 TIMP2
3 collagen catabolic process GO:0030574 9.54 MMP1 MMP14 MMP2
4 negative regulation of phosphorylation GO:0042326 9.48 CDKN1A CDKN2A
5 negative regulation of B cell proliferation GO:0030889 9.46 ATM CDKN2A
6 endothelial cell proliferation GO:0001935 9.43 HMOX1 MMP14
7 replicative senescence GO:0090399 9.33 ATM CDKN1A CDKN2A
8 heme oxidation GO:0006788 9.32 HMOX1 HMOX2
9 heme catabolic process GO:0042167 9.13 BLVRA HMOX1 HMOX2
10 response to hypoxia GO:0001666 9.1 ATM DPP4 HMOX1 HMOX2 MMP14 MMP2

Molecular functions related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.7 BLVRA CDKN1A DSG1 DSG3 HMOX1 HMOX2
2 integrin binding GO:0005178 9.61 ITGB3 MMP14 TIMP2
3 metalloendopeptidase activity GO:0004222 9.58 MMP1 MMP14 MMP2
4 serine-type endopeptidase activity GO:0004252 9.56 DPP4 MMP1 MMP14 MMP2
5 protease binding GO:0002020 9.54 DPP4 ITGB3 TIMP2
6 virus receptor activity GO:0001618 9.33 DPP4 ITGB3 XPR1
7 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.32 CDKN1A CDKN2A
8 heme oxygenase (decyclizing) activity GO:0004392 8.62 HMOX1 HMOX2

Sources for Nodular Malignant Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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