MCID: NDL001
MIFTS: 41

Nodular Malignant Melanoma malady

Summaries for Nodular Malignant Melanoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

MalaCards: Nodular Malignant Melanoma, also known as nodular melanoma, is related to melanoma and squamous cell carcinoma. An important gene associated with Nodular Malignant Melanoma is SOX10 (SRY (sex determining region Y)-box 10), and among its related pathways are Oxygen-dependent Asparagine Hydroxylation of Hypoxia-inducible Factor Alpha and TP53 network. The compounds cycloheximide and delta 7-pga1 have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and endothelial, and related mouse phenotypes are embryogenesis and skeleton.

Aliases & Classifications for Nodular Malignant Melanoma

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8Disease Ontology, 10DISEASES, 42NIH Rare Diseases, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

nodular malignant melanoma 8 10
nodular melanoma 8 42 60


External Ids:

Disease Ontology8 DOID:10047
SNOMED-CT56 254731001, 2142002
NCIt39 C4225

Related Diseases for Nodular Malignant Melanoma

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17GeneCards, 18GeneDecks
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Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma31.0SOX10, VEGFA, HIF1A, MYC, CDKN1A
2squamous cell carcinoma30.1CDKN1A, TYMP, MYC, HIF1A, VEGFA
3rectum malignant melanoma10.1
4malignant eyelid melanoma10.1
5malignant acrospiroma10.1
6eccrine acrospiroma10.1
7nodular hidradenoma10.1
8hidradenoma10.1
9psoriasis10.1
10skin melanoma10.1
11acral lentiginous melanoma10.0
12keratoacanthoma10.0
13leiomyoma10.0TYMP
14neurofibroma10.0SOX10
15pilocytic astrocytoma10.0SOX10
16hepatitis b10.0TYMP
17hepatitis c10.0TYMP
18plasmacytoma10.0MYC
19hepatitis10.0TYMP
20tongue cancer10.0CDKN1A
21hemangioma10.0VEGFA
22thyroid cancer10.0CDKN1A
23paraganglioma10.0HIF1A
24retinopathy of prematurity10.0VEGFA
25colon adenocarcinoma10.0CDKN1A
26polycythemia10.0HIF1A
27cervical squamous cell carcinoma10.0CDKN1A, TYMP
28deficiency anemia10.0HIF1A, EPAS1
29endometriosis10.0TYMP, VEGFA
30pheochromocytoma10.0HIF1A, EPAS1
31von hippel-lindau disease10.0VEGFA, HIF1A
32laryngeal squamous cell carcinoma10.0VEGFA, CDKN1A
33rheumatoid arthritis10.0TYMP, VEGFA
34oral cancer10.0CDKN1A, HIF1A
35rectal neoplasm10.0CDKN1A, TYMP
36breast cancer10.0EPAS1, TYMP, MYC
37oligodendroglioma10.0CDKN1A, SOX10
38kidney rhabdoid cancer10.0VEGFA, HIF1A, TYMP
39gastric adenocarcinoma10.0HIF1A, MYC, TYMP
40retinal ischemia10.0HIF1A, VEGFA
41ischemia10.0HIF1A, VEGFA
42myeloma10.0CDKN1A, MYC, VEGFA
43glioblastoma multiforme10.0VEGFA, HIF1A, CDKN1A
44cervical cancer10.0HIF1A, MYC, TYMP, CDKN1A
45kidney cancer10.0VEGFA, HIF1A, TYMP, EPAS1
46bladder carcinoma10.0EPAS1, CDKN1A, TYMP, VEGFA
47astrocytoma10.0CDKN1A, TYMP, HIF1A, VEGFA
48malignant glioma10.0VEGFA, HIF1A, CDKN1A
49lung adenocarcinoma10.0VEGFA, HIF1A, TYMP, CDKN1A
50squamous cell carcinoma of the head and neck10.0VEGFA, HIF1A, MYC, TYMP, CDKN1A

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to nodular malignant melanoma

Clinical Features for Nodular Malignant Melanoma

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Drugs & Therapeutics for Nodular Malignant Melanoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Nodular Malignant Melanoma

Search NIH Clinical Center for Nodular Malignant Melanoma

Search CenterWatch for Nodular Malignant Melanoma

Genetic Tests for Nodular Malignant Melanoma

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Anatomical Context for Nodular Malignant Melanoma

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32MalaCards
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MalaCards organs/tissues related to Nodular Malignant Melanoma:

32
Skin, Lymph node, Endothelial

Animal Models for Nodular Malignant Melanoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nodular Malignant Melanoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.7EPAS1, SOX10
2MP:00053909.4VEGFA, MYC, CDKN1A
3MP:00053718.9CDKN1A, MYC, HIF1A, VEGFA, SOX10
4MP:00053708.9EPAS1, CDKN1A, MYC, HIF1A, VEGFA

Publications for Nodular Malignant Melanoma

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50PubMed
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Articles related to Nodular Malignant Melanoma:

(show all 20)
idTitleAuthorsYear
1
A rare tumor of the face: malignant nodular hidradenoma with dermoscopic features mimicking amelanotic melanoma. (21561586)
2011
2
SOX10 expression in superficial spreading and nodular malignant melanomas. (20890226)
2010
3
Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. (21390477)
2010
4
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. (19550360)
2009
5
Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. (18319032)
2008
6
Nodular malignant melanoma with Spitz nevus-like pathological features finally confirmed by the pathological feature of the sentinel lymph node. (18078408)
2007
7
Immunohistochemical study of melanocytic differentiation antigens in cutaneous malignant melanoma. A comparison of six commercial antibodies and one non-commercial antibody in nodular melanoma, superficially spreading melanoma and lentigo maligna melanoma. (15233017)
2004
8
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. (14512791)
2003
9
c-MYC and nodular malignant melanoma. A case report. (10897006)
2000
10
Nodular malignant melanoma - Secondary to carcinoma rectum. (20944369)
1997
11
Digital occurrence of nodular malignant melanoma. (9110528)
1997
12
Analysis of ras mutations in human melanocytic lesions: activation of the ras gene seems to be associated with the nodular type of human malignant melanoma. (7860615)
1995
13
Nodular malignant melanoma. (1597831)
1992
14
Factor XIIIa in nodular malignant melanoma and Spitz naevi. (1979912)
1990
15
A comparative study of Spitz nevus and nodular malignant melanoma using image analysis cytometry. (3295064)
1987
16
Nodular malignant melanoma of upper eyelid. (6470506)
1984
17
Nodular malignant melanoma and multiple squamous cell carcinomas in a patient treated by photochemotherapy for psoriasis. (6439287)
1984
18
Nodular malignant melanoma: a distinct entity or a common end stage? (7149203)
1982
19
Clinical differentiation of adult-onset cavernous angioma from nodular malignant melanoma. (7369746)
1980
20
Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma. (50762)
1975

Genetic Variations for Nodular Malignant Melanoma

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Expression for genes affiliated with Nodular Malignant Melanoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nodular Malignant Melanoma

Search GEO for disease gene expression data for Nodular Malignant Melanoma.

Pathways for genes affiliated with Nodular Malignant Melanoma

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53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9EPAS1, HIF1A
29.8CDKN1A, MYC
39.8HIF1A, VEGFA
4
Development PDGF signaling via STATs and NF-kB
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9.6MYC, CDKN1A, EPAS1
59.5EPAS1, CDKN1A, HIF1A
6
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9.5EPAS1, HIF1A, VEGFA
7
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9.5EPAS1, HIF1A, VEGFA
8
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9.5CDKN1A, MYC, VEGFA
99.4VEGFA, HIF1A, CDKN1A
10
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9.2VEGFA, HIF1A, MYC, EPAS1
11
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9.2VEGFA, MYC, TYMP, CDKN1A
129.1VEGFA, HIF1A, MYC, CDKN1A
139.0IFNA8, VEGFA, MYC, CDKN1A
148.9VEGFA, HIF1A, MYC, CDKN1A, EPAS1

Compounds for genes affiliated with Nodular Malignant Melanoma

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6TYMP
2delta 7-pga14410.3MYC, CDKN1A
3hrgbeta14410.2MYC, CDKN1A
43-(5-hydroxymethyl-2-furyl)-1-benzylindazole4410.2VEGFA, HIF1A
5pga24410.2MYC, CDKN1A
610-hydroxycamptothecin4410.2MYC, CDKN1A
7tomudex4410.1TYMP, CDKN1A
8mezerein4410.1MYC, CDKN1A
9everolimus49 44 1112.1MYC, VEGFA
10capecitabine44 49 1112.0TYMP, VEGFA
11su54164410.0VEGFA, HIF1A
12taxane449.9VEGFA, TYMP, CDKN1A
13mithramycin449.9CDKN1A, VEGFA, MYC
14oxaliplatin44 49 1111.9TYMP, VEGFA, CDKN1A
15vincristine44 49 1111.9HIF1A, MYC, TYMP
16ns 39844 5910.8HIF1A, CDKN1A, VEGFA
17arsenite44 2410.8CDKN1A, VEGFA, HIF1A
1815-deoxy-delta-12,14-prostaglandin j2449.8VEGFA, CDKN1A, MYC
19lactacystin449.8HIF1A, MYC, CDKN1A
20flavopiridol44 1110.8HIF1A, CDKN1A, VEGFA
21celecoxib44 59 28 49 11 2414.8VEGFA, HIF1A, CDKN1A
22thymidylate449.8TYMP, CDKN1A, VEGFA
23cobalt chloride449.8VEGFA, HIF1A
24geldanamycin44 49 59 1112.8CDKN1A, VEGFA, HIF1A
25adriamycin449.7CDKN1A, MYC, HIF1A
26resveratrol44 59 11 2412.7VEGFA, CDKN1A, HIF1A
273,3-diindolylmethane449.7CDKN1A, VEGFA
28camptothecin44 59 1111.7HIF1A, MYC, CDKN1A
29irinotecan44 49 1111.6CDKN1A, TYMP, VEGFA, HIF1A
30bortezomib44 1110.6VEGFA, HIF1A, CDKN1A, MYC
31pd 98,059449.6EPAS1, CDKN1A, HIF1A, MYC
325fluorouracil449.6TYMP, HIF1A, VEGFA, CDKN1A
33mg 13244 5910.6VEGFA, HIF1A, MYC, CDKN1A
34n acetylcysteine449.5HIF1A, CDKN1A, VEGFA, MYC
35egcg449.5VEGFA, HIF1A, CDKN1A
36rapamycin449.5VEGFA, CDKN1A, HIF1A, MYC
37imatinib44 49 1111.5MYC, CDKN1A, VEGFA
38genistein44 28 59 2 11 2414.4CDKN1A, MYC, HIF1A, VEGFA
39gemcitabine44 49 1111.3CDKN1A, TYMP, MYC, HIF1A, VEGFA
40docetaxel44 49 59 1112.3TYMP, MYC, HIF1A, VEGFA, CDKN1A
41tamoxifen44 49 28 1112.3VEGFA, HIF1A, MYC, CDKN1A, TYMP
42paclitaxel44 49 1111.3CDKN1A, VEGFA, HIF1A, MYC, TYMP
43ly294002449.3CDKN1A, MYC, TYMP, HIF1A, VEGFA
44doxorubicin44 49 1111.3CDKN1A, TYMP, MYC, HIF1A, VEGFA
45actinomycin d449.3TYMP, VEGFA, MYC, HIF1A, CDKN1A
46paraffin449.3VEGFA, MYC, TYMP, HIF1A, CDKN1A
47cisplatin44 49 59 1112.3HIF1A, TYMP, CDKN1A, VEGFA, MYC
48vegf449.0VEGFA, CDKN1A, EPAS1, MYC, TYMP, HIF1A
49thymidine44 2410.0CDKN1A, MYC, HIF1A, TYMP
50tyrosine448.5MYC, VEGFA, SEC23IP, EPAS1, TYMP, HIF1A

GO Terms for genes affiliated with Nodular Malignant Melanoma

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16Gene Ontology
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Cellular components related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.8EPAS1, CDKN1A, MYC, HIF1A, DIS3
2cytosolGO:0058297.6ALDH7A1, DIS3, HIF1A, TYMP, CDKN1A, EPAS1

Biological processes related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:04361910.1HIF1A, EPAS1
2positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141910.0VEGFA, HIF1A
3surfactant homeostasisGO:04312910.0VEGFA, EPAS1
4digestive tract morphogenesisGO:04854610.0SOX10, HIF1A
5dopaminergic neuron differentiationGO:0715429.9HIF1A, VEGFA
6cell maturationGO:0484699.9EPAS1, VEGFA, SOX10
7positive regulation of neuroblast proliferationGO:0020529.8HIF1A, VEGFA, SOX10
8regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.8VEGFA, HIF1A, EPAS1
9positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.8VEGFA, HIF1A
10cellular response to hypoxiaGO:0714569.7EPAS1, HIF1A, VEGFA
11embryonic placenta developmentGO:0018929.6HIF1A, EPAS1
12angiogenesisGO:0015259.5EPAS1, TYMP, HIF1A, VEGFA
13response to hypoxiaGO:0016669.4EPAS1, HIF1A, VEGFA
14negative regulation of apoptotic processGO:0430669.2CDKN1A, MYC, VEGFA, SOX10
15positive regulation of transcription from RNA polymerase II promoterGO:0459449.1SOX10, VEGFA, HIF1A, MYC, EPAS1

Molecular functions related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase bindingGO:0350359.9EPAS1, HIF1A
2platelet-derived growth factor receptor bindingGO:0051619.5TYMP, VEGFA
3transcription factor bindingGO:0081349.2EPAS1, MYC, HIF1A, SOX10

Products for genes affiliated with Nodular Malignant Melanoma

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Sources for Nodular Malignant Melanoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet