MCID: NDL001
MIFTS: 48

Nodular Malignant Melanoma malady

Rare diseases, Cancer diseases categories
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Summaries for Nodular Malignant Melanoma

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Disease Ontology:8 A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.

MalaCards based summary: Nodular Malignant Melanoma, also known as nodular melanoma, is related to melanoma and spitz nevus. An important gene associated with Nodular Malignant Melanoma is SOX10 (SRY (sex determining region Y)-box 10), and among its related pathways are Notch signaling pathway and TP53 network. The compounds delta 7-pga1 and hrgbeta1 have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and endothelial, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Wikipedia:65 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

Aliases & Classifications for Nodular Malignant Melanoma

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Nodular Malignant Melanoma, Aliases & Descriptions:

Name: Nodular Malignant Melanoma 8 10 62
 
Nodular Melanoma 8 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:10047
SNOMED-CT57 2142002, 254731001
NCIt39 C4225

Related Diseases for Nodular Malignant Melanoma

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Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma30.3VEGFA, HIF1A, SOX10, MYC, CDKN1A
2spitz nevus10.3
3superficial spreading melanoma10.3
4leukodystrophy10.3TYMP, SOX10
5erythrocytosis10.2HIF1A
6lentigo maligna melanoma10.2
7cervical squamous cell carcinoma10.2CDKN1A, TYMP
8nodular hidradenoma10.2
9eccrine acrospiroma10.2
10hidradenoma10.2
11psoriasis10.2
12acrospiroma10.2
13hypoxia10.2
14endotheliitis10.2
15rectal neoplasm10.2TYMP, CDKN1A
16grade iii astrocytoma10.1TYMP, VEGFA
17laryngeal squamous cell carcinoma10.1VEGFA, CDKN1A
18oligodendroglioma10.1SOX10, CDKN1A
19acral lentiginous melanoma10.0
20keratoacanthoma10.0
21cutaneous malignant melanoma10.0
22retinal ischemia10.0VEGFA, HIF1A
23kidney cancer10.0VEGFA, EPAS1
24hemangioblastoma10.0VEGFA, HIF1A
25von hippel-lindau disease10.0HIF1A, VEGFA
26proliferative diabetic retinopathy10.0VEGFA, HIF1A
27breast cancer10.0MYC, EPAS1, TYMP
28renal clear cell carcinoma10.0VEGFA, HIF1A
29bladder carcinoma9.9CDKN1A, TYMP
30kidney rhabdoid cancer9.9HIF1A, VEGFA, TYMP
31diabetic retinopathy9.9HIF1A, VEGFA
32squamous cell carcinoma of the head and neck9.9CDKN1A, HIF1A, TYMP
33lung cancer9.9VEGFA, CDKN1A, MYC
34myeloma9.8VEGFA, CDKN1A, MYC
35gastric adenocarcinoma9.8MYC, TYMP, HIF1A
36glioblastoma multiforme9.8VEGFA, HIF1A, CDKN1A
37malignant glioma9.8HIF1A, VEGFA, CDKN1A
38prostate cancer9.7CDKN1A, HIF1A, MYC
39osteosarcoma9.7HIF1A, CDKN1A, MYC
40lung adenocarcinoma9.7TYMP, VEGFA, HIF1A, CDKN1A
41astrocytoma9.6HIF1A, VEGFA, TYMP, CDKN1A
42pancreatic cancer9.6HIF1A, VEGFA, CDKN1A, TYMP
43cervical cancer9.6MYC, HIF1A, TYMP, CDKN1A
44endometrial carcinoma9.4MYC, CDKN1A, HIF1A, VEGFA, TYMP
45glioblastoma9.4HIF1A, MYC, CDKN1A, TYMP, VEGFA
46non-small cell lung carcinoma9.4MYC, CDKN1A, VEGFA, TYMP, HIF1A
47stomach cancer9.4VEGFA, HIF1A, TYMP, MYC, CDKN1A
48ovarian cancer9.4CDKN1A, TYMP, VEGFA, HIF1A, MYC
49colonic benign neoplasm9.4MYC, VEGFA, TYMP, HIF1A, CDKN1A
50colorectal cancer9.4MYC, VEGFA, TYMP, CDKN1A, HIF1A

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to nodular malignant melanoma

Symptoms for Nodular Malignant Melanoma

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Drugs & Therapeutics for Nodular Malignant Melanoma

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Drug clinical trials:

Search ClinicalTrials for Nodular Malignant Melanoma

Search NIH Clinical Center for Nodular Malignant Melanoma

Genetic Tests for Nodular Malignant Melanoma

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Anatomical Context for Nodular Malignant Melanoma

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MalaCards organs/tissues related to Nodular Malignant Melanoma:

32
Skin, Lymph node, Endothelial

Animal Models for Nodular Malignant Melanoma or affiliated genes

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MGI Mouse Phenotypes related to Nodular Malignant Melanoma:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7VEGFA, HIF1A, SOX10, MYC, CDKN1A
2MP:00053888.7VEGFA, HIF1A, SOX10, EPAS1, CDKN1A
3MP:00020068.7VEGFA, HIF1A, SOX10, MYC, CDKN1A
4MP:00053828.7CDKN1A, MYC, SOX10, HIF1A, VEGFA
5MP:00053708.6VEGFA, HIF1A, EPAS1, MYC, CDKN1A
6MP:00053818.6VEGFA, HIF1A, SOX10, MYC, CDKN1A
7MP:00053698.6VEGFA, HIF1A, EPAS1, MYC, CDKN1A
8MP:00053798.5VEGFA, HIF1A, SOX10, MYC, CDKN1A
9MP:00107718.5VEGFA, HIF1A, SOX10, MYC, CDKN1A
10MP:00053808.4VEGFA, HIF1A, SOX10, EPAS1, MYC, CDKN1A
11MP:00053908.4CDKN1A, MYC, EPAS1, HIF1A, VEGFA, TYMP
12MP:00030128.3CDKN1A, MYC, SEC23IP, VEGFA
13MP:00053878.2TYMP, VEGFA, HIF1A, EPAS1, MYC, CDKN1A
14MP:00053848.1TYMP, VEGFA, HIF1A, SOX10, MYC, CDKN1A
15MP:00053858.1VEGFA, HIF1A, EPAS1, MYC, CDKN1A
16MP:00036318.0TYMP, VEGFA, HIF1A, SOX10, EPAS1, MYC
17MP:00053768.0TYMP, VEGFA, HIF1A, SOX10, EPAS1, MYC
18MP:00053788.0VEGFA, HIF1A, SOX10, EPAS1, MYC, CDKN1A
19MP:00107687.7G3BP2, VEGFA, HIF1A, SOX10, EPAS1, MYC

Publications for Nodular Malignant Melanoma

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Articles related to Nodular Malignant Melanoma:

(show all 17)
idTitleAuthorsYear
1
Nodular malignant melanoma. Or maybe not? (24635092)
2014
2
SOX10 expression in superficial spreading and nodular malignant melanomas. (20890226)
2010
3
Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. (21390477)
2010
4
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. (19550360)
2009
5
Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. (18319032)
2008
6
Nodular malignant melanoma with Spitz nevus-like pathological features finally confirmed by the pathological feature of the sentinel lymph node. (18078408)
2007
7
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. (14512791)
2003
8
c-MYC and nodular malignant melanoma. A case report. (10897006)
2000
9
Nodular malignant melanoma - Secondary to carcinoma rectum. (20944369)
1997
10
Digital occurrence of nodular malignant melanoma. (9110528)
1997
11
Nodular malignant melanoma. (1597831)
1992
12
Factor XIIIa in nodular malignant melanoma and Spitz naevi. (1979912)
1990
13
A comparative study of Spitz nevus and nodular malignant melanoma using image analysis cytometry. (3295064)
1987
14
Nodular malignant melanoma of upper eyelid. (6470506)
1984
15
Nodular malignant melanoma and multiple squamous cell carcinomas in a patient treated by photochemotherapy for psoriasis. (6439287)
1984
16
Nodular malignant melanoma: a distinct entity or a common end stage? (7149203)
1982
17
Clinical differentiation of adult-onset cavernous angioma from nodular malignant melanoma. (7369746)
1980

Variations for Nodular Malignant Melanoma

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Expression for genes affiliated with Nodular Malignant Melanoma

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Expression patterns in normal tissues for genes affiliated with Nodular Malignant Melanoma

Search GEO for disease gene expression data for Nodular Malignant Melanoma.

Pathways for genes affiliated with Nodular Malignant Melanoma

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Pathways related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Notch signaling pathway37
9.7CDKN1A, MYC
2
Show member pathways
9.7CDKN1A, MYC
39.7CDKN1A, MYC
49.7CDKN1A, MYC
59.6MYC, HIF1A
69.6EPAS1, VEGFA
79.6VEGFA, CDKN1A
89.6CDKN1A, VEGFA
9
Show member pathways
9.5HIF1A, VEGFA
109.5HIF1A, VEGFA
11
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.5HIF1A, VEGFA
12
Show member pathways
Angiogenesis37
9.5HIF1A, VEGFA
13
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.3EPAS1, MYC, CDKN1A
149.3CDKN1A, EPAS1, HIF1A
159.2VEGFA, MYC, CDKN1A
169.2VEGFA, MYC, CDKN1A
17
Show member pathways
9.2CDKN1A, MYC, VEGFA
189.2CDKN1A, MYC, VEGFA
19
Show member pathways
9.2VEGFA, HIF1A, EPAS1
20
Show member pathways
VEGFR1 specific signals37
9.2EPAS1, HIF1A, VEGFA
219.2VEGFA, HIF1A, EPAS1
229.1VEGFA, HIF1A, CDKN1A
23
Show member pathways
8.9HIF1A, SOX10, MYC, CDKN1A
24
Show member pathways
Signaling Pathways in Glioblastoma37
8.9TYMP, VEGFA, MYC, CDKN1A
25
Show member pathways
8.8CDKN1A, EPAS1, HIF1A, VEGFA
268.7VEGFA, HIF1A, MYC, CDKN1A
278.4CDKN1A, MYC, EPAS1, HIF1A, VEGFA
28
Show member pathways
8.1VEGFA, HIF1A, MYC, NMS, CDKN1A

Compounds for genes affiliated with Nodular Malignant Melanoma

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Compounds related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1delta 7-pga14410.1MYC, CDKN1A
2hrgbeta14410.0MYC, CDKN1A
3pga24410.0MYC, CDKN1A
43-(5-hydroxymethyl-2-furyl)-1-benzylindazole449.9HIF1A, VEGFA
510-hydroxycamptothecin449.9CDKN1A, MYC
6tomudex449.8TYMP, CDKN1A
7mezerein449.8CDKN1A, MYC
8taxane449.7VEGFA, CDKN1A, TYMP
9oxaliplatin44 50 1111.6TYMP, VEGFA, CDKN1A
10mithramycin449.6CDKN1A, MYC, VEGFA
11vincristine44 50 1111.5TYMP, MYC, HIF1A
12carboplatin44 50 1111.5VEGFA, HIF1A, SOX10
13thymidylate449.5VEGFA, TYMP, CDKN1A
14lactacystin449.5CDKN1A, HIF1A, MYC
1515-deoxy-delta-12,14-prostaglandin j2449.5CDKN1A, MYC, VEGFA
16ns 39844 6110.5CDKN1A, HIF1A, VEGFA
17everolimus44 50 1111.5VEGFA, HIF1A, MYC
18flavopiridol44 1110.5HIF1A, VEGFA, CDKN1A
19celecoxib44 61 28 50 24 1114.5CDKN1A, VEGFA, HIF1A
20adriamycin449.4HIF1A, CDKN1A, MYC
21geldanamycin44 50 61 1112.4CDKN1A, VEGFA, HIF1A
22camptothecin44 61 1111.4HIF1A, MYC, CDKN1A
23resveratrol44 61 24 1112.3HIF1A, CDKN1A, VEGFA
24irinotecan44 50 1111.2CDKN1A, HIF1A, VEGFA, TYMP
25pd 98,059449.2MYC, CDKN1A, HIF1A, EPAS1
26egcg449.2CDKN1A, HIF1A, VEGFA
27su5416449.2HIF1A, VEGFA
285fluorouracil449.2HIF1A, CDKN1A, TYMP, VEGFA
29cyclophosphamide44 50 1111.2VEGFA, HIF1A, TYMP
30bortezomib44 50 1111.2VEGFA, MYC, CDKN1A, HIF1A
31thymidine44 2410.2CDKN1A, MYC, HIF1A, TYMP
32mg 13244 6110.1VEGFA, HIF1A, CDKN1A, MYC
33arsenite44 2410.1CDKN1A, MYC, HIF1A, VEGFA
34n acetylcysteine449.1VEGFA, CDKN1A, MYC, HIF1A
35rapamycin449.1VEGFA, HIF1A, MYC, CDKN1A
36imatinib44 50 1111.1CDKN1A, VEGFA, MYC
37genistein44 28 61 2 24 1114.0VEGFA, HIF1A, MYC, CDKN1A
38gemcitabine44 50 1110.8VEGFA, TYMP, HIF1A, MYC, CDKN1A
39tamoxifen44 50 28 1111.8VEGFA, HIF1A, MYC, TYMP, CDKN1A
40ly294002448.8CDKN1A, MYC, TYMP, VEGFA, HIF1A
41doxorubicin44 50 1110.8MYC, CDKN1A, HIF1A, VEGFA, TYMP
42actinomycin d448.8MYC, VEGFA, CDKN1A, TYMP, HIF1A
43paraffin448.8HIF1A, MYC, CDKN1A, VEGFA, TYMP
44cisplatin44 50 61 1111.8TYMP, CDKN1A, MYC, HIF1A, VEGFA
45cycloheximide448.8MYC, CDKN1A, HIF1A, VEGFA, TYMP
46estrogen448.7CDKN1A, MYC, HIF1A, VEGFA, TYMP
47docetaxel44 50 61 1111.5VEGFA, HIF1A, SOX10, MYC, CDKN1A, TYMP
48paclitaxel44 50 1110.5CDKN1A, MYC, SOX10, HIF1A, VEGFA, TYMP
49vegf448.5CDKN1A, EPAS1, HIF1A, VEGFA, MYC, TYMP
50tyrosine447.6TYMP, VEGFA, SEC23IP, MYC, EPAS1, HIF1A

GO Terms for genes affiliated with Nodular Malignant Melanoma

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Cellular components related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.9CDKN1A, MYC, EPAS1, HIF1A

Biological processes related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:04361910.0EPAS1, HIF1A
2digestive tract morphogenesisGO:04854610.0SOX10, HIF1A
3surfactant homeostasisGO:0431299.9VEGFA, EPAS1
4embryonic placenta developmentGO:0018929.9EPAS1, HIF1A
5neural crest cell migrationGO:0017559.9HIF1A, SOX10
6positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.8VEGFA, HIF1A
7dopaminergic neuron differentiationGO:0715429.8HIF1A, VEGFA
8positive regulation of fibroblast proliferationGO:0481469.8CDKN1A, MYC
9positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.8HIF1A, VEGFA
10positive regulation of mesenchymal cell proliferationGO:0020539.7MYC, VEGFA
11outflow tract morphogenesisGO:0031519.7VEGFA, HIF1A
12cell maturationGO:0484699.7VEGFA, SOX10, EPAS1
13lactationGO:0075959.6HIF1A, VEGFA
14regulation of gene expressionGO:0104689.6HIF1A, MYC
15positive regulation of neuroblast proliferationGO:0020529.6SOX10, HIF1A, VEGFA
16regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.5EPAS1, HIF1A, VEGFA
17positive regulation of endothelial cell proliferationGO:0019389.5HIF1A, VEGFA
18cellular response to hypoxiaGO:0714569.5EPAS1, HIF1A, VEGFA
19positive regulation of epithelial cell proliferationGO:0506799.4MYC, VEGFA
20response to hypoxiaGO:0016669.4VEGFA, HIF1A, EPAS1
21cellular iron ion homeostasisGO:0068799.3MYC, HIF1A
22angiogenesisGO:0015259.2EPAS1, HIF1A, VEGFA, TYMP
23negative regulation of apoptotic processGO:0430669.2CDKN1A, MYC, SOX10, VEGFA
24positive regulation of transcription from RNA polymerase II promoterGO:0459449.0VEGFA, HIF1A, EPAS1, MYC

Molecular functions related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor bindingGO:0051619.5TYMP, VEGFA
2histone acetyltransferase bindingGO:0350359.4EPAS1, HIF1A
3protein heterodimerization activityGO:0469829.2EPAS1, HIF1A, VEGFA
4transcription factor bindingGO:0081349.0MYC, EPAS1, SOX10, HIF1A

Products for genes affiliated with Nodular Malignant Melanoma

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Sources for Nodular Malignant Melanoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
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