MCID: NDL001
MIFTS: 40

Nodular Malignant Melanoma malady

Rare diseases category

Aliases & Classifications for Nodular Malignant Melanoma

About this section

Aliases & Descriptions for Nodular Malignant Melanoma:

Name: Nodular Malignant Melanoma 8 10
 
Nodular Melanoma 8 42 61


Classifications:



External Ids:

Disease Ontology8 DOID:10047
SNOMED-CT56 2142002, 254731001
NCIt39 C4225

Summaries for Nodular Malignant Melanoma

About this section
Disease Ontology:8 A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.

MalaCards based summary: Nodular Malignant Melanoma, also known as nodular melanoma, is related to melanoma and spitz nevus. An important gene associated with Nodular Malignant Melanoma is SOX10 (SRY (sex determining region Y)-box 10), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and Notch signaling pathway. The compounds delta 7-pga1 and hrgbeta1 have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and endothelial, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Wikipedia:64 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

Related Diseases for Nodular Malignant Melanoma

About this section

Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma30.3CDKN1A, MYC, SOX10, HIF1A, VEGFA
2spitz nevus10.3
3superficial spreading melanoma10.3
4leukodystrophy10.3SOX10, TYMP
5lentigo maligna melanoma10.2
6eccrine acrospiroma10.2
7nodular hidradenoma10.2
8hidradenoma10.2
9psoriasis10.2
10acrospiroma10.2
11hypoxia10.2
12endotheliitis10.2
13rectal neoplasm10.2TYMP, CDKN1A
14cervical squamous cell carcinoma10.2TYMP, CDKN1A
15grade iii astrocytoma10.1VEGFA, TYMP
16laryngeal squamous cell carcinoma10.1CDKN1A, VEGFA
17acral lentiginous melanoma10.0
18keratoacanthoma10.0
19renal cell carcinoma10.0VEGFA, EPAS1
20retinal ischemia10.0VEGFA, HIF1A
21bladder cancer, somatic10.0CDKN1A, TYMP
22hemangioblastoma10.0HIF1A, VEGFA
23von hippel-lindau syndrome10.0VEGFA, HIF1A
24oligodendroglioma10.0CDKN1A, SOX10
25microvascular complications of diabetes 110.0HIF1A, VEGFA
26breast cancer10.0MYC, EPAS1, TYMP
27renal clear cell carcinoma9.9HIF1A, VEGFA
28microvascular complications of diabetes 59.9HIF1A, VEGFA
29squamous cell carcinoma, head and neck9.9CDKN1A, HIF1A, TYMP
30lung cancer9.8CDKN1A, MYC, VEGFA
31myeloma9.8VEGFA, MYC, CDKN1A
32gastric adenocarcinoma9.8TYMP, HIF1A, MYC
33glioblastoma multiforme9.8CDKN1A, HIF1A, VEGFA
34malignant glioma9.8CDKN1A, HIF1A, VEGFA
35prostate cancer9.7CDKN1A, MYC, HIF1A
36osteosarcoma, somatic9.7HIF1A, MYC, CDKN1A
37kidney cancer9.7TYMP, VEGFA, HIF1A, EPAS1
38lung cancer susceptibility 39.7TYMP, VEGFA, HIF1A, CDKN1A
39astrocytoma9.6TYMP, VEGFA, HIF1A, CDKN1A
40pancreatic cancer9.6CDKN1A, HIF1A, VEGFA, TYMP
41cervical cancer, somatic9.6CDKN1A, MYC, HIF1A, TYMP
42endometrial cancer9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
43stomach cancer9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
44glioblastoma9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
45gastric cancer, somatic9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
46ovarian cancer, somatic9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
47colorectal cancer9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
48tongue squamous cell carcinoma9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
49adenocarcinoma9.4CDKN1A, MYC, HIF1A, VEGFA, TYMP
50hepatocellular carcinoma9.2TYMP, VEGFA, HIF1A, EPAS1, MYC, CDKN1A

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to nodular malignant melanoma

Symptoms for Nodular Malignant Melanoma

About this section

Drugs & Therapeutics for Nodular Malignant Melanoma

About this section

Drug clinical trials:

Search ClinicalTrials for Nodular Malignant Melanoma

Search NIH Clinical Center for Nodular Malignant Melanoma

Genetic Tests for Nodular Malignant Melanoma

About this section

Anatomical Context for Nodular Malignant Melanoma

About this section

MalaCards organs/tissues related to Nodular Malignant Melanoma:

31
Skin, Lymph node, Endothelial

Animal Models for Nodular Malignant Melanoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Nodular Malignant Melanoma:

35 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7VEGFA, HIF1A, MYC, CDKN1A, SOX10
2MP:00053888.7CDKN1A, EPAS1, SOX10, HIF1A, VEGFA
3MP:00020068.7SOX10, CDKN1A, MYC, HIF1A, VEGFA
4MP:00053828.7VEGFA, HIF1A, SOX10, MYC, CDKN1A
5MP:00053708.6EPAS1, MYC, CDKN1A, HIF1A, VEGFA
6MP:00053818.6VEGFA, HIF1A, SOX10, MYC, CDKN1A
7MP:00053698.6CDKN1A, MYC, EPAS1, HIF1A, VEGFA
8MP:00053798.5CDKN1A, HIF1A, SOX10, VEGFA, MYC
9MP:00107718.5VEGFA, CDKN1A, MYC, SOX10, HIF1A
10MP:00053808.4HIF1A, VEGFA, EPAS1, MYC, CDKN1A, SOX10
11MP:00053908.4CDKN1A, TYMP, VEGFA, HIF1A, EPAS1, MYC
12MP:00030128.3MYC, VEGFA, SEC23IP, CDKN1A
13MP:00053878.2VEGFA, TYMP, HIF1A, EPAS1, MYC, CDKN1A
14MP:00053848.1CDKN1A, MYC, SOX10, VEGFA, TYMP, HIF1A
15MP:00053858.1HIF1A, VEGFA, EPAS1, MYC, CDKN1A
16MP:00036318.0TYMP, VEGFA, SOX10, EPAS1, CDKN1A, MYC
17MP:00053768.0HIF1A, TYMP, VEGFA, SOX10, EPAS1, MYC
18MP:00053788.0CDKN1A, MYC, EPAS1, SOX10, HIF1A, VEGFA
19MP:00107687.7VEGFA, G3BP2, HIF1A, SOX10, EPAS1, MYC

Publications for Nodular Malignant Melanoma

About this section

Articles related to Nodular Malignant Melanoma:

(show all 17)
idTitleAuthorsYear
1
Nodular malignant melanoma. Or maybe not? (24635092)
2014
2
SOX10 expression in superficial spreading and nodular malignant melanomas. (20890226)
2010
3
Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. (21390477)
2010
4
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. (19550360)
2009
5
Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. (18319032)
2008
6
Nodular malignant melanoma with Spitz nevus-like pathological features finally confirmed by the pathological feature of the sentinel lymph node. (18078408)
2007
7
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. (14512791)
2003
8
c-MYC and nodular malignant melanoma. A case report. (10897006)
2000
9
Nodular malignant melanoma - Secondary to carcinoma rectum. (20944369)
1997
10
Digital occurrence of nodular malignant melanoma. (9110528)
1997
11
Nodular malignant melanoma. (1597831)
1992
12
Factor XIIIa in nodular malignant melanoma and Spitz naevi. (1979912)
1990
13
A comparative study of Spitz nevus and nodular malignant melanoma using image analysis cytometry. (3295064)
1987
14
Nodular malignant melanoma of upper eyelid. (6470506)
1984
15
Nodular malignant melanoma and multiple squamous cell carcinomas in a patient treated by photochemotherapy for psoriasis. (6439287)
1984
16
Nodular malignant melanoma: a distinct entity or a common end stage? (7149203)
1982
17
Clinical differentiation of adult-onset cavernous angioma from nodular malignant melanoma. (7369746)
1980

Variations for Nodular Malignant Melanoma

About this section

Expression for genes affiliated with Nodular Malignant Melanoma

About this section
Search GEO for disease gene expression data for Nodular Malignant Melanoma.

Pathways for genes affiliated with Nodular Malignant Melanoma

About this section

Pathways related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MYC, CDKN1A
2
Show member pathways
Notch signaling pathway36
9.7CDKN1A, MYC
3
Show member pathways
9.7CDKN1A, MYC
49.7CDKN1A, MYC
59.6HIF1A, MYC
69.6EPAS1, VEGFA
79.6VEGFA, CDKN1A
89.6CDKN1A, VEGFA
9
Show member pathways
9.5HIF1A, VEGFA
109.5HIF1A, VEGFA
11
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway59
9.5HIF1A, VEGFA
12
Show member pathways
Angiogenesis36
9.5VEGFA, HIF1A
13
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.3MYC, EPAS1, CDKN1A
149.3HIF1A, EPAS1, CDKN1A
159.2VEGFA, MYC, CDKN1A
169.2VEGFA, MYC, CDKN1A
17
Show member pathways
9.2MYC, CDKN1A, VEGFA
189.2MYC, VEGFA, CDKN1A
19
Show member pathways
9.2EPAS1, VEGFA, HIF1A
209.2HIF1A, VEGFA, EPAS1
21
Show member pathways
VEGFR1 specific signals36
9.2VEGFA, HIF1A, EPAS1
229.1CDKN1A, VEGFA, HIF1A
23
Show member pathways
8.9SOX10, MYC, CDKN1A, HIF1A
24
Show member pathways
Signaling Pathways in Glioblastoma36
8.9TYMP, VEGFA, MYC, CDKN1A
25
Show member pathways
8.8CDKN1A, EPAS1, HIF1A, VEGFA
268.7HIF1A, CDKN1A, MYC, VEGFA
278.4HIF1A, EPAS1, VEGFA, CDKN1A, MYC
28
Show member pathways
8.1NMS, CDKN1A, VEGFA, HIF1A, MYC

Compounds for genes affiliated with Nodular Malignant Melanoma

About this section

Compounds related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1delta 7-pga14410.1MYC, CDKN1A
2hrgbeta14410.0MYC, CDKN1A
3pga24410.0MYC, CDKN1A
43-(5-hydroxymethyl-2-furyl)-1-benzylindazole449.9HIF1A, VEGFA
510-hydroxycamptothecin449.9CDKN1A, MYC
6tomudex449.8TYMP, CDKN1A
7mezerein449.8CDKN1A, MYC
8taxane449.7VEGFA, CDKN1A, TYMP
9oxaliplatin44 50 1111.6TYMP, VEGFA, CDKN1A
10mithramycin449.6CDKN1A, MYC, VEGFA
11vincristine44 50 1111.5TYMP, MYC, HIF1A
12carboplatin44 50 1111.5VEGFA, HIF1A, SOX10
13thymidylate449.5VEGFA, TYMP, CDKN1A
14lactacystin449.5CDKN1A, HIF1A, MYC
1515-deoxy-delta-12,14-prostaglandin j2449.5CDKN1A, MYC, VEGFA
16ns 39844 6010.5CDKN1A, HIF1A, VEGFA
17everolimus44 50 1111.5VEGFA, HIF1A, MYC
18flavopiridol44 1110.5HIF1A, VEGFA, CDKN1A
19celecoxib44 60 28 50 24 1114.5CDKN1A, VEGFA, HIF1A
20adriamycin449.4HIF1A, CDKN1A, MYC
21geldanamycin44 50 60 1112.4CDKN1A, VEGFA, HIF1A
22camptothecin44 60 1111.4HIF1A, MYC, CDKN1A
23resveratrol44 60 24 1112.3HIF1A, CDKN1A, VEGFA
24irinotecan44 50 1111.2CDKN1A, HIF1A, VEGFA, TYMP
25pd 98,059449.2MYC, CDKN1A, HIF1A, EPAS1
26egcg449.2CDKN1A, HIF1A, VEGFA
27su5416449.2HIF1A, VEGFA
285fluorouracil449.2HIF1A, CDKN1A, TYMP, VEGFA
29cyclophosphamide44 50 1111.2VEGFA, HIF1A, TYMP
30bortezomib44 50 1111.2VEGFA, MYC, CDKN1A, HIF1A
31thymidine44 2410.2CDKN1A, MYC, HIF1A, TYMP
32mg 13244 6010.1VEGFA, HIF1A, CDKN1A, MYC
33arsenite44 2410.1CDKN1A, MYC, HIF1A, VEGFA
34n acetylcysteine449.1VEGFA, CDKN1A, MYC, HIF1A
35rapamycin449.1VEGFA, HIF1A, MYC, CDKN1A
36imatinib44 50 1111.1CDKN1A, VEGFA, MYC
37genistein44 28 60 1 24 1114.0VEGFA, HIF1A, MYC, CDKN1A
38gemcitabine44 50 1110.8VEGFA, TYMP, HIF1A, MYC, CDKN1A
39tamoxifen44 50 28 1111.8VEGFA, HIF1A, MYC, TYMP, CDKN1A
40ly294002448.8CDKN1A, MYC, TYMP, VEGFA, HIF1A
41doxorubicin44 50 1110.8MYC, CDKN1A, HIF1A, VEGFA, TYMP
42actinomycin d448.8MYC, VEGFA, CDKN1A, TYMP, HIF1A
43paraffin448.8HIF1A, MYC, CDKN1A, VEGFA, TYMP
44cisplatin44 50 60 1111.8TYMP, CDKN1A, MYC, HIF1A, VEGFA
45cycloheximide448.8MYC, CDKN1A, HIF1A, VEGFA, TYMP
46estrogen448.7CDKN1A, MYC, HIF1A, VEGFA, TYMP
47docetaxel44 50 60 1111.5VEGFA, HIF1A, SOX10, MYC, CDKN1A, TYMP
48paclitaxel44 50 1110.5CDKN1A, MYC, SOX10, HIF1A, VEGFA, TYMP
49vegf448.5CDKN1A, EPAS1, HIF1A, VEGFA, MYC, TYMP
50tyrosine447.6TYMP, VEGFA, SEC23IP, MYC, EPAS1, HIF1A

GO Terms for genes affiliated with Nodular Malignant Melanoma

About this section

Cellular components related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00056548.9CDKN1A, MYC, EPAS1, HIF1A

Biological processes related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:004361910.0HIF1A, EPAS1
2digestive tract morphogenesisGO:004854610.0SOX10, HIF1A
3surfactant homeostasisGO:00431299.9VEGFA, EPAS1
4embryonic placenta developmentGO:00018929.9EPAS1, HIF1A
5neural crest cell migrationGO:00017559.9SOX10, HIF1A
6positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:00614199.8HIF1A, VEGFA
7dopaminergic neuron differentiationGO:00715429.8HIF1A, VEGFA
8positive regulation of fibroblast proliferationGO:00481469.8CDKN1A, MYC
9positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:00309499.8VEGFA, HIF1A
10positive regulation of mesenchymal cell proliferationGO:00020539.7MYC, VEGFA
11cell maturationGO:00484699.7SOX10, VEGFA, EPAS1
12outflow tract morphogenesisGO:00031519.6HIF1A, VEGFA
13lactationGO:00075959.6VEGFA, HIF1A
14regulation of gene expressionGO:00104689.6MYC, HIF1A
15positive regulation of neuroblast proliferationGO:00020529.6HIF1A, VEGFA, SOX10
16regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:00614189.5VEGFA, EPAS1, HIF1A
17positive regulation of endothelial cell proliferationGO:00019389.5VEGFA, HIF1A
18cellular response to hypoxiaGO:00714569.5EPAS1, HIF1A, VEGFA
19positive regulation of epithelial cell proliferationGO:00506799.4VEGFA, MYC
20response to hypoxiaGO:00016669.4EPAS1, VEGFA, HIF1A
21cellular iron ion homeostasisGO:00068799.3MYC, HIF1A
22angiogenesisGO:00015259.2EPAS1, TYMP, VEGFA, HIF1A
23negative regulation of apoptotic processGO:00430669.2CDKN1A, SOX10, VEGFA, MYC
24positive regulation of transcription from RNA polymerase II promoterGO:00459449.0MYC, VEGFA, HIF1A, EPAS1

Molecular functions related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor bindingGO:00051619.5TYMP, VEGFA
2histone acetyltransferase bindingGO:00350359.4EPAS1, HIF1A
3protein heterodimerization activityGO:00469829.2EPAS1, HIF1A, VEGFA
4transcription factor bindingGO:00081349.0MYC, EPAS1, SOX10, HIF1A

Sources for Nodular Malignant Melanoma

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet