MCID: NDL001
MIFTS: 39

Nodular Malignant Melanoma malady

Summaries for Nodular Malignant Melanoma

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

MalaCards: Nodular Malignant Melanoma, also known as nodular melanoma, is related to squamous cell carcinoma and spitz nevus. An important gene associated with Nodular Malignant Melanoma is SOX10 (SRY (sex determining region Y)-box 10), and among its related pathways are Oxygen-dependent Asparagine Hydroxylation of Hypoxia-inducible Factor Alpha and TP53 network. The compounds cycloheximide and delta 7-pga1 have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and endothelial, and related mouse phenotypes are embryogenesis and skeleton.

Aliases & Classifications for Nodular Malignant Melanoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 57SNOMED-CT, 40NCIt
See all sources

Aliases & Descriptions:

nodular malignant melanoma 8 10
nodular melanoma 8 43 61


External Ids:

Disease Ontology8 DOID:10047
SNOMED-CT57 254731001, 2142002
NCIt40 C4225

Related Diseases for Nodular Malignant Melanoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.2CDKN1A, TYMP, MYC, HIF1A, VEGFA
2spitz nevus10.3
3lentigo maligna melanoma10.2
4rectum malignant melanoma10.2
5malignant eyelid melanoma10.2
6malignant acrospiroma10.2
7eccrine acrospiroma10.2
8nodular hidradenoma10.2
9acrospiroma10.2
10superficial spreading melanoma10.2
11cutaneous malignant melanoma10.2
12hypoxia10.2
13acral lentiginous melanoma10.0
14leiomyoma10.0TYMP
15neurofibroma10.0SOX10
16pilocytic astrocytoma10.0SOX10
17hepatitis b10.0TYMP
18hepatitis c10.0TYMP
19plasmacytoma10.0MYC
20hepatitis10.0TYMP
21tongue cancer10.0CDKN1A
22hemangioma10.0VEGFA
23thyroid cancer10.0CDKN1A
24paraganglioma10.0HIF1A
25retinopathy of prematurity10.0VEGFA
26colon adenocarcinoma10.0CDKN1A
27polycythemia10.0HIF1A
28cervical squamous cell carcinoma10.0CDKN1A, TYMP
29deficiency anemia10.0HIF1A, EPAS1
30endometriosis10.0TYMP, VEGFA
31pheochromocytoma10.0HIF1A, EPAS1
32von hippel-lindau disease10.0VEGFA, HIF1A
33laryngeal squamous cell carcinoma10.0VEGFA, CDKN1A
34rheumatoid arthritis10.0TYMP, VEGFA
35oral cancer10.0CDKN1A, HIF1A
36rectum cancer10.0CDKN1A, TYMP
37breast cancer10.0EPAS1, TYMP, MYC
38oligodendroglioma10.0CDKN1A, SOX10
39kidney rhabdoid cancer10.0VEGFA, HIF1A, TYMP
40gastric adenocarcinoma10.0HIF1A, MYC, TYMP
41retinal ischemia10.0HIF1A, VEGFA
42ischemia10.0HIF1A, VEGFA
43myeloma10.0CDKN1A, MYC, VEGFA
44glioblastoma multiforme10.0VEGFA, HIF1A, CDKN1A
45cervical cancer10.0HIF1A, MYC, TYMP, CDKN1A
46kidney cancer10.0VEGFA, HIF1A, TYMP, EPAS1
47bladder carcinoma10.0EPAS1, CDKN1A, TYMP, VEGFA
48astrocytoma10.0CDKN1A, TYMP, HIF1A, VEGFA
49malignant glioma10.0VEGFA, HIF1A, CDKN1A
50lung adenocarcinoma10.0VEGFA, HIF1A, TYMP, CDKN1A

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to nodular malignant melanoma

Clinical Features for Nodular Malignant Melanoma

Drugs & Therapeutics for Nodular Malignant Melanoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Nodular Malignant Melanoma

Drug clinical trials:

Search ClinicalTrials for Nodular Malignant Melanoma

Search NIH Clinical Center for Nodular Malignant Melanoma

Search CenterWatch for Nodular Malignant Melanoma

Genetic Tests for Nodular Malignant Melanoma

Anatomical Context for Nodular Malignant Melanoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Nodular Malignant Melanoma:

33
Lymph node, Skin, Endothelial

Animal Models for Nodular Malignant Melanoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Nodular Malignant Melanoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.7EPAS1, SOX10
2MP:00053909.4VEGFA, MYC, CDKN1A
3MP:00053718.9CDKN1A, MYC, HIF1A, VEGFA, SOX10
4MP:00053708.9EPAS1, CDKN1A, MYC, HIF1A, VEGFA

Publications for Nodular Malignant Melanoma

Sources:
51PubMed
See all sources

Articles related to Nodular Malignant Melanoma:

(show all 20)
idTitleAuthorsYear
1
A rare tumor of the face: malignant nodular hidradenoma with dermoscopic features mimicking amelanotic melanoma. (21561586)
2011
2
SOX10 expression in superficial spreading and nodular malignant melanomas. (20890226)
2010
3
Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. (21390477)
2010
4
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. (19550360)
2009
5
Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. (18319032)
2008
6
Nodular malignant melanoma with Spitz nevus-like pathological features finally confirmed by the pathological feature of the sentinel lymph node. (18078408)
2007
7
Immunohistochemical study of melanocytic differentiation antigens in cutaneous malignant melanoma. A comparison of six commercial antibodies and one non-commercial antibody in nodular melanoma, superficially spreading melanoma and lentigo maligna melanoma. (15233017)
2004
8
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. (14512791)
2003
9
c-MYC and nodular malignant melanoma. A case report. (10897006)
2000
10
Nodular malignant melanoma - Secondary to carcinoma rectum. (20944369)
1997
11
Digital occurrence of nodular malignant melanoma. (9110528)
1997
12
Analysis of ras mutations in human melanocytic lesions: activation of the ras gene seems to be associated with the nodular type of human malignant melanoma. (7860615)
1995
13
Nodular malignant melanoma. (1597831)
1992
14
Factor XIIIa in nodular malignant melanoma and Spitz naevi. (1979912)
1990
15
A comparative study of Spitz nevus and nodular malignant melanoma using image analysis cytometry. (3295064)
1987
16
Nodular malignant melanoma of upper eyelid. (6470506)
1984
17
Nodular malignant melanoma and multiple squamous cell carcinomas in a patient treated by photochemotherapy for psoriasis. (6439287)
1984
18
Nodular malignant melanoma: a distinct entity or a common end stage? (7149203)
1982
19
Clinical differentiation of adult-onset cavernous angioma from nodular malignant melanoma. (7369746)
1980
20
Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma. (50762)
1975

Genetic Variations for Nodular Malignant Melanoma

Expression for genes affiliated with Nodular Malignant Melanoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Nodular Malignant Melanoma

Search GEO for disease gene expression data for Nodular Malignant Melanoma.

Pathways for genes affiliated with Nodular Malignant Melanoma

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9EPAS1, HIF1A
29.8CDKN1A, MYC
39.8HIF1A, VEGFA
4
Development PDGF signaling via STATs and NF-kB
Hide members
9.6MYC, CDKN1A, EPAS1
59.5EPAS1, CDKN1A, HIF1A
6
Hide members
9.5EPAS1, HIF1A, VEGFA
7
Hide members
9.5EPAS1, HIF1A, VEGFA
8
Hide members
9.5CDKN1A, MYC, VEGFA
99.4VEGFA, HIF1A, CDKN1A
10
Hide members
9.2VEGFA, HIF1A, MYC, EPAS1
11
Hide members
9.2VEGFA, MYC, TYMP, CDKN1A
129.1VEGFA, HIF1A, MYC, CDKN1A
139.0IFNA8, VEGFA, MYC, CDKN1A
148.9VEGFA, HIF1A, MYC, CDKN1A, EPAS1

Compounds for genes affiliated with Nodular Malignant Melanoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.6TYMP
2delta 7-pga14510.3CDKN1A, MYC
3hrgbeta14510.2CDKN1A, MYC
43-(5-hydroxymethyl-2-furyl)-1-benzylindazole4510.2HIF1A, VEGFA
5pga24510.2CDKN1A, MYC
610-hydroxycamptothecin4510.2MYC, CDKN1A
7tomudex4510.1CDKN1A, TYMP
8mezerein4510.1MYC, CDKN1A
9everolimus50 45 1112.1MYC, VEGFA
10capecitabine45 50 1112.0VEGFA, TYMP
11su54164510.0VEGFA, HIF1A
12taxane459.9CDKN1A, TYMP, VEGFA
13mithramycin459.9VEGFA, MYC, CDKN1A
14oxaliplatin45 50 1111.9VEGFA, TYMP, CDKN1A
15vincristine45 50 1111.9TYMP, MYC, HIF1A
16ns 39845 6010.8VEGFA, HIF1A, CDKN1A
17arsenite45 2410.8CDKN1A, HIF1A, VEGFA
1815-deoxy-delta-12,14-prostaglandin j2459.8VEGFA, MYC, CDKN1A
19lactacystin459.8CDKN1A, MYC, HIF1A
20flavopiridol45 1110.8CDKN1A, HIF1A, VEGFA
21celecoxib45 60 29 50 11 2414.8VEGFA, HIF1A, CDKN1A
22thymidylate459.8VEGFA, TYMP, CDKN1A
23cobalt chloride459.8VEGFA, HIF1A
24geldanamycin45 50 60 1112.8VEGFA, HIF1A, CDKN1A
25adriamycin459.7CDKN1A, MYC, HIF1A
26resveratrol45 60 11 2412.7CDKN1A, HIF1A, VEGFA
273,3-diindolylmethane459.7CDKN1A, VEGFA
28camptothecin45 60 1111.7CDKN1A, MYC, HIF1A
29irinotecan45 50 1111.6CDKN1A, TYMP, HIF1A, VEGFA
30bortezomib45 1110.6VEGFA, HIF1A, MYC, CDKN1A
31pd 98,059459.6HIF1A, MYC, CDKN1A, EPAS1
325fluorouracil459.6CDKN1A, TYMP, HIF1A, VEGFA
33mg 13245 6010.6VEGFA, HIF1A, MYC, CDKN1A
34n acetylcysteine459.5VEGFA, HIF1A, MYC, CDKN1A
35egcg459.5CDKN1A, HIF1A, VEGFA
36rapamycin459.5VEGFA, HIF1A, MYC, CDKN1A
37imatinib45 50 1111.5CDKN1A, MYC, VEGFA
38genistein45 29 60 2 11 2414.4VEGFA, HIF1A, MYC, CDKN1A
39gemcitabine45 50 1111.3CDKN1A, TYMP, MYC, HIF1A, VEGFA
40docetaxel45 50 60 1112.3VEGFA, HIF1A, MYC, TYMP, CDKN1A
41tamoxifen45 50 29 1112.3CDKN1A, TYMP, MYC, HIF1A, VEGFA
42paclitaxel45 50 1111.3VEGFA, HIF1A, MYC, TYMP, CDKN1A
43ly294002459.3VEGFA, HIF1A, MYC, TYMP, CDKN1A
44doxorubicin45 50 1111.3VEGFA, HIF1A, MYC, TYMP, CDKN1A
45actinomycin d459.3VEGFA, HIF1A, MYC, TYMP, CDKN1A
46paraffin459.3VEGFA, HIF1A, MYC, TYMP, CDKN1A
47cisplatin45 50 60 1112.3VEGFA, HIF1A, MYC, TYMP, CDKN1A
48vegf459.0VEGFA, HIF1A, MYC, TYMP, CDKN1A, EPAS1
49thymidine45 2410.0HIF1A, MYC, TYMP, CDKN1A
50tyrosine458.5SEC23IP, EPAS1, CDKN1A, TYMP, MYC, HIF1A

GO Terms for genes affiliated with Nodular Malignant Melanoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.8EPAS1, CDKN1A, MYC, HIF1A, DIS3
2cytosolGO:0058297.6ALDH7A1, DIS3, HIF1A, TYMP, CDKN1A, EPAS1

Biological processes related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:04361910.1HIF1A, EPAS1
2positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141910.0VEGFA, HIF1A
3surfactant homeostasisGO:04312910.0VEGFA, EPAS1
4digestive tract morphogenesisGO:04854610.0SOX10, HIF1A
5dopaminergic neuron differentiationGO:0715429.9HIF1A, VEGFA
6cell maturationGO:0484699.9EPAS1, VEGFA, SOX10
7positive regulation of neuroblast proliferationGO:0020529.8HIF1A, VEGFA, SOX10
8regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.8VEGFA, HIF1A, EPAS1
9positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.8VEGFA, HIF1A
10cellular response to hypoxiaGO:0714569.7EPAS1, HIF1A, VEGFA
11embryonic placenta developmentGO:0018929.6HIF1A, EPAS1
12angiogenesisGO:0015259.5EPAS1, TYMP, HIF1A, VEGFA
13response to hypoxiaGO:0016669.4EPAS1, HIF1A, VEGFA
14negative regulation of apoptotic processGO:0430669.2CDKN1A, MYC, VEGFA, SOX10
15positive regulation of transcription from RNA polymerase II promoterGO:0459449.1SOX10, VEGFA, HIF1A, MYC, EPAS1

Molecular functions related to Nodular Malignant Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase bindingGO:0350359.9EPAS1, HIF1A
2platelet-derived growth factor receptor bindingGO:0051619.5TYMP, VEGFA
3transcription factor bindingGO:0081349.2EPAS1, MYC, HIF1A, SOX10

Products for genes affiliated with Nodular Malignant Melanoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nodular Malignant Melanoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet