MCID: NDL001
MIFTS: 40

Nodular Malignant Melanoma malady

Categories: Rare diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Nodular Malignant Melanoma

Aliases & Descriptions for Nodular Malignant Melanoma:

Name: Nodular Malignant Melanoma 12 14
Nodular Melanoma 12 50 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10047
NCIt 47 C4225
SNOMED-CT 64 2142002 254731001
UMLS 69 C0334424

Summaries for Nodular Malignant Melanoma

Disease Ontology : 12 A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.

MalaCards based summary : Nodular Malignant Melanoma, also known as nodular melanoma, is related to melanoma and neuropathy, hereditary sensory, type id. An important gene associated with Nodular Malignant Melanoma is XPR1 (Xenotropic And Polytropic Retrovirus Receptor 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and MicroRNAs in cancer. The drugs Bortezomib and Ceritinib have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and lymph node, and related phenotypes are shRNA abundance <= 50% and homeostasis/metabolism

Wikipedia : 71 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

Related Diseases for Nodular Malignant Melanoma

Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
id Related Disease Score Top Affiliating Genes
1 melanoma 10.3
2 neuropathy, hereditary sensory, type id 10.2 MMP14 MMP2
3 anisomastia 10.1 MMP14 MMP2
4 renal oncocytoma 10.1 HMOX1 MMP1 TIMP2
5 linear porokeratosis 10.1 MMP1 MMP14 MMP2
6 angiomyoma 10.1 MMP1 MMP2 TIMP2
7 adult neuronal ceroid lipofuscinosis 10.1 MMP1 MMP2 TIMP2
8 breast abscess 10.1 MMP1 MMP2 TIMP2
9 kleptomania 10.1 MMP1 MMP2
10 myalgia-eosinophilia syndrome associated with tryptophan 10.0 DSG1 DSG3
11 spinocerebellar ataxia, autosomal recessive 2 10.0 MMP1 MMP14 MMP2
12 mitochondrial encephalomyopathy 10.0 CDKN2A MMP14 MMP2
13 striated muscle rhabdoid tumor 10.0 CDKN2A MMP2 TIMP2
14 adenoid squamous cell carcinoma 10.0 CDKN2A MMP2 TIMP2
15 pediatric osteosarcoma 10.0 MMP1 MMP14 MMP2 TIMP2
16 mixed ductal-endocrine carcinoma 10.0 MMP1 MMP2 TIMP2
17 noonan syndrome 4 9.9 MMP1 MMP2
18 maxillary sinus cholesteatoma 9.9 CDKN1A CDKN2A MMP2
19 nasopharyngeal carcinoma 9.9 ATM CDKN1A CDKN2A
20 lattice corneal dystrophy 9.9 CDKN1A CDKN2A MMP2
21 immunodeficiency by defective expression of hla class 1 9.9 DSG1 DSG3
22 traumatic brain injury 9.9 CDKN2A MMP1 MMP14 MMP2
23 nodular cutaneous amyloidosis 9.9 CDKN2A MMP1 MMP2 TIMP2
24 in situ pulmonary adenocarcinoma 9.8 CDKN1A CDKN2A MMP1 MMP2
25 bardet-biedl syndrome 9.8 CDKN1A CDKN2A MMP2
26 spitz nevus 9.8
27 ladd syndrome 9.8 CDKN1A CDKN2A MMP2 TIMP2
28 nevoid hypermelanosis, linear and whorled 9.7 CDKN1A CDKN2A MMP1 MMP2 TIMP2
29 psoriasis 9.7
30 acrospiroma 9.7
31 hypoxia 9.7
32 endotheliitis 9.7
33 squamous cell carcinoma 9.7
34 nodular hidradenoma 9.7
35 vaginitis 9.7
36 hidradenoma 9.7
37 eccrine acrospiroma 9.7
38 subglottis neoplasm 7.9 ATM BLVRA CDKN1A CDKN2A DPP4 DSG1

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to Nodular Malignant Melanoma

Symptoms & Phenotypes for Nodular Malignant Melanoma

GenomeRNAi Phenotypes related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.32 ATM BLVRA CDKN1A DPP4 HMOX1 ITGB3

MGI Mouse Phenotypes related to Nodular Malignant Melanoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 ATM BLVRA CDKN1A CDKN2A DPP4 DSG3
2 cardiovascular system MP:0005385 10.06 ATM CDKN1A CDKN2A HMOX1 HMOX2 ITGB3
3 immune system MP:0005387 10.06 ATM CDKN1A CDKN2A DSG3 HMOX1 ITGB3
4 adipose tissue MP:0005375 9.91 CDKN1A DSG1 DSG3 HMOX1 MMP14 ATM
5 muscle MP:0005369 9.8 CDKN1A CDKN2A HMOX1 HMOX2 ITGB3 MMP14
6 neoplasm MP:0002006 9.63 ATM CDKN1A CDKN2A ITGB3 MMP1 MMP2
7 respiratory system MP:0005388 9.56 CDKN2A DSG3 HMOX1 HMOX2 ITGB3 MMP14
8 vision/eye MP:0005391 9.17 CDKN1A CDKN2A DSG1 DSG3 ITGB3 MMP14

Drugs & Therapeutics for Nodular Malignant Melanoma

Drugs for Nodular Malignant Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bortezomib Approved, Investigational Phase 4 179324-69-7 387447 93860
2
Ceritinib Approved Phase 4 1032900-25-6
3
Crizotinib Approved Phase 4 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
4
Dasatinib Approved, Investigational Phase 4 302962-49-8 3062316
5
Everolimus Approved Phase 4 159351-69-6 6442177
6
Gefitinib Approved, Investigational Phase 4 184475-35-2 123631
7
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
8
Olaparib Approved Phase 4 763113-22-0 23725625
9
Palbociclib Approved Phase 4 571190-30-2 11431660 5005498 5330286
10
Ramucirumab Approved, Investigational Phase 4 947687-13-0
11
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
12
Sorafenib Approved, Investigational Phase 4 284461-73-0 216239 406563
13
Sunitinib Approved, Investigational Phase 4 341031-54-7, 557795-19-4 5329102
14
Trametinib Approved Phase 4 871700-17-3 11707110
15
Vorinostat Approved, Investigational Phase 4 149647-78-9 5311
16
Lapatinib Approved March 2007, Investigational Phase 4 231277-92-2, 388082-78-8 208908 9941095
17 Anti-Infective Agents Phase 4,Phase 1
18 Anti-Bacterial Agents Phase 4
19 Antibiotics, Antitubercular Phase 4
20 Antifungal Agents Phase 4
21
Erlotinib Hydrochloride Phase 4 183319-69-9 176871
22 Imatinib Mesylate Phase 4 123596
23 Immunosuppressive Agents Phase 4
24 Poly(ADP-ribose) Polymerase Inhibitors Phase 4
25 Protein Kinase Inhibitors Phase 4
26
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
27
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
28
Etoposide Approved Phase 2 33419-42-0 36462
29
Ifosfamide Approved Phase 2 3778-73-2 3690
30
Mechlorethamine Approved Phase 2 51-75-2 4033
31
Pembrolizumab Approved Phase 2 1374853-91-4
32 Alkylating Agents Phase 2
33 Antimitotic Agents Phase 2
34 Antineoplastic Agents, Alkylating Phase 2
35 Antineoplastic Agents, Phytogenic Phase 2
36 Dermatologic Agents Phase 2
37 Etoposide phosphate Phase 2
38 Isophosphamide mustard Phase 2
39 Keratolytic Agents Phase 2
40 Podophyllotoxin Phase 2 518-28-5
41 Topoisomerase Inhibitors Phase 2
42
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
43 Antiviral Agents Phase 1
44 Ganciclovir triphosphate Phase 1
45 Nucleic Acid Synthesis Inhibitors Phase 1
46
Menthol Approved 2216-51-5 16666
47 Fluorodeoxyglucose F18
48 tyrosine Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Molecular Profiling and Matched Targeted Therapy for Patients With Metastatic Melanoma Not yet recruiting NCT02645149 Phase 4
2 Pembrolizumab and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma Recruiting NCT03077828 Phase 2
3 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2
4 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2
5 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1
6 cKIT, BRAF/NRAS Mutations in Advanced Melanoma : Clinical Outcome in Response to Tyrosine-kinase Inhibitors - KitMel Project Completed NCT01543113
7 Defining PET / CT Protocols With Optimized F18-FDG (Fluorodeoxyglucose) Dose, Focusing on Reduced Radiation Dose and Improved Image Quality Completed NCT02378337
8 Study of Families With Melanoma Recruiting NCT00445783

Search NIH Clinical Center for Nodular Malignant Melanoma

Genetic Tests for Nodular Malignant Melanoma

Anatomical Context for Nodular Malignant Melanoma

MalaCards organs/tissues related to Nodular Malignant Melanoma:

39
Skin, Endothelial, Lymph Node

Publications for Nodular Malignant Melanoma

Articles related to Nodular Malignant Melanoma:

(show all 19)
id Title Authors Year
1
Rare nodular malignant melanoma of the heel in the Caribbean: A case report. ( 28012339 )
2016
2
Vaginal Amelanotic Nodular Malignant Melanoma in A Middle-Aged Female: A Rare Case Report and Review of Literature. ( 26085744 )
2015
3
Nodular malignant melanoma. Or maybe not? ( 24635092 )
2014
4
Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. ( 21390477 )
2010
5
SOX10 expression in superficial spreading and nodular malignant melanomas. ( 20890226 )
2010
6
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. ( 19550360 )
2009
7
Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. ( 18319032 )
2008
8
Nodular malignant melanoma with Spitz nevus-like pathological features finally confirmed by the pathological feature of the sentinel lymph node. ( 18078408 )
2007
9
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. ( 14512791 )
2003
10
c-MYC and nodular malignant melanoma. A case report. ( 10897006 )
2000
11
Nodular malignant melanoma - Secondary to carcinoma rectum. ( 20944369 )
1997
12
Digital occurrence of nodular malignant melanoma. ( 9110528 )
1997
13
Nodular malignant melanoma. ( 1597831 )
1992
14
Factor XIIIa in nodular malignant melanoma and Spitz naevi. ( 1979912 )
1990
15
A comparative study of Spitz nevus and nodular malignant melanoma using image analysis cytometry. ( 3295064 )
1987
16
Nodular malignant melanoma and multiple squamous cell carcinomas in a patient treated by photochemotherapy for psoriasis. ( 6439287 )
1984
17
Nodular malignant melanoma of upper eyelid. ( 6470506 )
1984
18
Nodular malignant melanoma: a distinct entity or a common end stage? ( 7149203 )
1982
19
Clinical differentiation of adult-onset cavernous angioma from nodular malignant melanoma. ( 7369746 )
1980

Variations for Nodular Malignant Melanoma

Expression for Nodular Malignant Melanoma

Search GEO for disease gene expression data for Nodular Malignant Melanoma.

Pathways for Nodular Malignant Melanoma

Pathways related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.58 ITGB3 MMP1 MMP14 MMP2 TIMP2
2 12.31 ATM CDKN1A CDKN2A HMOX1 ITGB3
3 12 CDKN1A MMP1 MMP14 MMP2
4 11.8 ATM CDKN1A CDKN2A
5 11.78 ITGB3 MMP14 MMP2
6 11.75 CDKN1A CDKN2A MMP14
7 11.73 CDKN1A HMOX1 MMP1 MMP2
8
Show member pathways
11.62 MMP1 MMP14 MMP2 TIMP2
9 11.58 ATM CDKN1A CDKN2A
10 11.54 ATM CDKN1A CDKN2A MMP2
11 11.4 HMOX1 ITGB3 MMP2 TIMP2
12 11.38 CDKN1A CDKN2A MMP2
13 11.3 ATM CDKN1A MMP1
14 11.12 CDKN1A CDKN2A MMP1 MMP2
15 11.11 HMOX1 MMP1 MMP2
16 10.9 MMP1 MMP2
17
Show member pathways
10.78 ATM CDKN1A CDKN2A
18 10.71 MMP1 MMP14 MMP2 TIMP2

GO Terms for Nodular Malignant Melanoma

Cellular components related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.1 DSG1 MMP1 MMP14 MMP2 NES TIMP2
2 lamellipodium membrane GO:0031258 8.96 DPP4 ITGB3

Biological processes related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 9.58 DPP4 ITGB3 XPR1
2 extracellular matrix disassembly GO:0022617 9.56 MMP1 MMP14 MMP2 TIMP2
3 collagen catabolic process GO:0030574 9.54 MMP1 MMP14 MMP2
4 negative regulation of phosphorylation GO:0042326 9.48 CDKN1A CDKN2A
5 endothelial cell proliferation GO:0001935 9.46 HMOX1 MMP14
6 negative regulation of B cell proliferation GO:0030889 9.43 ATM CDKN2A
7 replicative senescence GO:0090399 9.33 ATM CDKN1A CDKN2A
8 heme oxidation GO:0006788 9.32 HMOX1 HMOX2
9 heme catabolic process GO:0042167 9.13 BLVRA HMOX1 HMOX2
10 response to hypoxia GO:0001666 9.1 ATM DPP4 HMOX1 HMOX2 MMP14 MMP2

Molecular functions related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.7 BLVRA CDKN1A DSG1 DSG3 HMOX1 HMOX2
2 serine-type endopeptidase activity GO:0004252 9.62 DPP4 MMP1 MMP14 MMP2
3 metalloendopeptidase activity GO:0004222 9.58 MMP1 MMP14 MMP2
4 protease binding GO:0002020 9.54 DPP4 ITGB3 TIMP2
5 virus receptor activity GO:0001618 9.33 DPP4 ITGB3 XPR1
6 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.26 CDKN1A CDKN2A
7 heme oxygenase (decyclizing) activity GO:0004392 8.62 HMOX1 HMOX2

Sources for Nodular Malignant Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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