MCID: NDL001
MIFTS: 40

Nodular Malignant Melanoma malady

Rare diseases category

Summaries for Nodular Malignant Melanoma

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Disease Ontology:9 A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule.

MalaCards based summary: Nodular Malignant Melanoma, also known as nodular melanoma, is related to melanoma and spitz nevus. An important gene associated with Nodular Malignant Melanoma is SOX10 (SRY (sex determining region Y)-box 10), and among its related pathways are Notch signaling pathway and TP53 network. The compounds delta 7-pga1 and hrgbeta1 have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and endothelial, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Wikipedia:63 Nodular melanoma (NM) is the most aggressive form of melanoma. It tends to grow more rapidly in... more...

Aliases & Classifications for Nodular Malignant Melanoma

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Nodular Malignant Melanoma, Aliases & Descriptions:

Name: Nodular Malignant Melanoma 9 11
 
Nodular Melanoma 9 41 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:10047
SNOMED-CT55 2142002, 254731001
NCIt38 C4225

Related Diseases for Nodular Malignant Melanoma

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Diseases related to Nodular Malignant Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma30.3CDKN1A, MYC, SOX10, HIF1A, VEGFA
2spitz nevus10.3
3superficial spreading melanoma10.3
4leukodystrophy10.3SOX10, TYMP
5lentigo maligna melanoma10.2
6eccrine acrospiroma10.2
7nodular hidradenoma10.2
8hidradenoma10.2
9psoriasis10.2
10acrospiroma10.2
11hypoxia10.2
12endotheliitis10.2
13rectal neoplasm10.2TYMP, CDKN1A
14cervical squamous cell carcinoma10.2TYMP, CDKN1A
15grade iii astrocytoma10.1VEGFA, TYMP
16laryngeal squamous cell carcinoma10.1CDKN1A, VEGFA
17acral lentiginous melanoma10.0
18keratoacanthoma10.0
19renal cell carcinoma10.0VEGFA, EPAS1
20retinal ischemia10.0VEGFA, HIF1A
21bladder cancer, somatic10.0CDKN1A, TYMP
22hemangioblastoma10.0HIF1A, VEGFA
23von hippel-lindau syndrome10.0VEGFA, HIF1A
24oligodendroglioma10.0CDKN1A, SOX10
25microvascular complications of diabetes 110.0HIF1A, VEGFA
26breast cancer10.0MYC, EPAS1, TYMP
27renal clear cell carcinoma9.9HIF1A, VEGFA
28microvascular complications of diabetes 59.9HIF1A, VEGFA
29squamous cell carcinoma, head and neck9.9CDKN1A, HIF1A, TYMP
30lung cancer9.8CDKN1A, MYC, VEGFA
31myeloma9.8VEGFA, MYC, CDKN1A
32gastric adenocarcinoma9.8TYMP, HIF1A, MYC
33glioblastoma multiforme9.8CDKN1A, HIF1A, VEGFA
34malignant glioma9.8CDKN1A, HIF1A, VEGFA
35prostate cancer9.7CDKN1A, MYC, HIF1A
36osteosarcoma, somatic9.7HIF1A, MYC, CDKN1A
37kidney cancer9.7TYMP, VEGFA, HIF1A, EPAS1
38lung cancer susceptibility 39.7TYMP, VEGFA, HIF1A, CDKN1A
39astrocytoma9.6TYMP, VEGFA, HIF1A, CDKN1A
40pancreatic cancer9.6CDKN1A, HIF1A, VEGFA, TYMP
41cervical cancer, somatic9.6CDKN1A, MYC, HIF1A, TYMP
42endometrial cancer9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
43stomach cancer9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
44glioblastoma9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
45gastric cancer, somatic9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
46ovarian cancer, somatic9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
47colorectal cancer9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
48tongue squamous cell carcinoma9.4TYMP, VEGFA, HIF1A, MYC, CDKN1A
49adenocarcinoma9.4CDKN1A, MYC, HIF1A, VEGFA, TYMP
50hepatocellular carcinoma9.2TYMP, VEGFA, HIF1A, EPAS1, MYC, CDKN1A

Graphical network of the top 20 diseases related to Nodular Malignant Melanoma:



Diseases related to nodular malignant melanoma

Symptoms for Nodular Malignant Melanoma

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Drugs & Therapeutics for Nodular Malignant Melanoma

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Drug clinical trials:

Search ClinicalTrials for Nodular Malignant Melanoma

Search NIH Clinical Center for Nodular Malignant Melanoma

Genetic Tests for Nodular Malignant Melanoma

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Anatomical Context for Nodular Malignant Melanoma

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MalaCards organs/tissues related to Nodular Malignant Melanoma:

31
Skin, Lymph node, Endothelial

Animal Models for Nodular Malignant Melanoma or affiliated genes

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MGI Mouse Phenotypes related to Nodular Malignant Melanoma:

35 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7VEGFA, HIF1A, SOX10, MYC, CDKN1A
2MP:00053888.7VEGFA, HIF1A, SOX10, EPAS1, CDKN1A
3MP:00020068.7VEGFA, HIF1A, SOX10, MYC, CDKN1A
4MP:00053828.7CDKN1A, MYC, SOX10, HIF1A, VEGFA
5MP:00053708.6VEGFA, HIF1A, EPAS1, MYC, CDKN1A
6MP:00053818.6VEGFA, HIF1A, SOX10, MYC, CDKN1A
7MP:00053698.6VEGFA, HIF1A, EPAS1, MYC, CDKN1A
8MP:00053798.5VEGFA, HIF1A, SOX10, MYC, CDKN1A
9MP:00107718.5VEGFA, HIF1A, SOX10, MYC, CDKN1A
10MP:00053808.4VEGFA, HIF1A, SOX10, EPAS1, MYC, CDKN1A
11MP:00053908.4CDKN1A, MYC, EPAS1, HIF1A, VEGFA, TYMP
12MP:00030128.3CDKN1A, MYC, SEC23IP, VEGFA
13MP:00053878.2TYMP, VEGFA, HIF1A, EPAS1, MYC, CDKN1A
14MP:00053848.1TYMP, VEGFA, HIF1A, SOX10, MYC, CDKN1A
15MP:00053858.1VEGFA, HIF1A, EPAS1, MYC, CDKN1A
16MP:00036318.0TYMP, VEGFA, HIF1A, SOX10, EPAS1, MYC
17MP:00053768.0TYMP, VEGFA, HIF1A, SOX10, EPAS1, MYC
18MP:00053788.0VEGFA, HIF1A, SOX10, EPAS1, MYC, CDKN1A
19MP:00107687.7G3BP2, VEGFA, HIF1A, SOX10, EPAS1, MYC

Publications for Nodular Malignant Melanoma

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Articles related to Nodular Malignant Melanoma:

(show all 17)
idTitleAuthorsYear
1
Nodular malignant melanoma. Or maybe not? (24635092)
2014
2
SOX10 expression in superficial spreading and nodular malignant melanomas. (20890226)
2010
3
Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. (21390477)
2010
4
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. (19550360)
2009
5
Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. (18319032)
2008
6
Nodular malignant melanoma with Spitz nevus-like pathological features finally confirmed by the pathological feature of the sentinel lymph node. (18078408)
2007
7
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. (14512791)
2003
8
c-MYC and nodular malignant melanoma. A case report. (10897006)
2000
9
Nodular malignant melanoma - Secondary to carcinoma rectum. (20944369)
1997
10
Digital occurrence of nodular malignant melanoma. (9110528)
1997
11
Nodular malignant melanoma. (1597831)
1992
12
Factor XIIIa in nodular malignant melanoma and Spitz naevi. (1979912)
1990
13
A comparative study of Spitz nevus and nodular malignant melanoma using image analysis cytometry. (3295064)
1987
14
Nodular malignant melanoma of upper eyelid. (6470506)
1984
15
Nodular malignant melanoma and multiple squamous cell carcinomas in a patient treated by photochemotherapy for psoriasis. (6439287)
1984
16
Nodular malignant melanoma: a distinct entity or a common end stage? (7149203)
1982
17
Clinical differentiation of adult-onset cavernous angioma from nodular malignant melanoma. (7369746)
1980

Variations for Nodular Malignant Melanoma

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Expression for genes affiliated with Nodular Malignant Melanoma

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Search GEO for disease gene expression data for Nodular Malignant Melanoma.

Pathways for genes affiliated with Nodular Malignant Melanoma

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Pathways related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Notch signaling pathway36
9.7CDKN1A, MYC
2
Show member pathways
9.7CDKN1A, MYC
39.7CDKN1A, MYC
49.7CDKN1A, MYC
59.6MYC, HIF1A
69.6EPAS1, VEGFA
79.6VEGFA, CDKN1A
89.6CDKN1A, VEGFA
9
Show member pathways
9.5HIF1A, VEGFA
109.5HIF1A, VEGFA
11
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway58
9.5HIF1A, VEGFA
12
Show member pathways
Angiogenesis36
9.5HIF1A, VEGFA
13
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.3EPAS1, MYC, CDKN1A
149.3CDKN1A, EPAS1, HIF1A
159.2VEGFA, MYC, CDKN1A
169.2VEGFA, MYC, CDKN1A
17
Show member pathways
9.2CDKN1A, MYC, VEGFA
189.2CDKN1A, MYC, VEGFA
19
Show member pathways
9.2VEGFA, HIF1A, EPAS1
20
Show member pathways
VEGFR1 specific signals36
9.2EPAS1, HIF1A, VEGFA
219.2VEGFA, HIF1A, EPAS1
229.1VEGFA, HIF1A, CDKN1A
23
Show member pathways
8.9HIF1A, SOX10, MYC, CDKN1A
24
Show member pathways
Signaling Pathways in Glioblastoma36
8.9TYMP, VEGFA, MYC, CDKN1A
25
Show member pathways
8.8CDKN1A, EPAS1, HIF1A, VEGFA
268.7VEGFA, HIF1A, MYC, CDKN1A
278.4CDKN1A, MYC, EPAS1, HIF1A, VEGFA
28
Show member pathways
8.1VEGFA, HIF1A, MYC, NMS, CDKN1A

Compounds for genes affiliated with Nodular Malignant Melanoma

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Compounds related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1delta 7-pga14310.1MYC, CDKN1A
2hrgbeta14310.0MYC, CDKN1A
3pga24310.0MYC, CDKN1A
43-(5-hydroxymethyl-2-furyl)-1-benzylindazole439.9HIF1A, VEGFA
510-hydroxycamptothecin439.9CDKN1A, MYC
6tomudex439.8TYMP, CDKN1A
7mezerein439.8CDKN1A, MYC
8taxane439.7VEGFA, CDKN1A, TYMP
9oxaliplatin43 49 1211.6TYMP, VEGFA, CDKN1A
10mithramycin439.6CDKN1A, MYC, VEGFA
11vincristine43 49 1211.5TYMP, MYC, HIF1A
12carboplatin43 49 1211.5VEGFA, HIF1A, SOX10
13thymidylate439.5VEGFA, TYMP, CDKN1A
14lactacystin439.5CDKN1A, HIF1A, MYC
1515-deoxy-delta-12,14-prostaglandin j2439.5CDKN1A, MYC, VEGFA
16ns 39843 5910.5CDKN1A, HIF1A, VEGFA
17everolimus43 49 1211.5VEGFA, HIF1A, MYC
18flavopiridol43 1210.5HIF1A, VEGFA, CDKN1A
19celecoxib43 59 28 49 24 1214.5CDKN1A, VEGFA, HIF1A
20adriamycin439.4HIF1A, CDKN1A, MYC
21geldanamycin43 49 59 1212.4CDKN1A, VEGFA, HIF1A
22camptothecin43 59 1211.4HIF1A, MYC, CDKN1A
23resveratrol43 59 24 1212.3HIF1A, CDKN1A, VEGFA
24irinotecan43 49 1211.2CDKN1A, HIF1A, VEGFA, TYMP
25pd 98,059439.2MYC, CDKN1A, HIF1A, EPAS1
26egcg439.2CDKN1A, HIF1A, VEGFA
27su5416439.2HIF1A, VEGFA
285fluorouracil439.2HIF1A, CDKN1A, TYMP, VEGFA
29cyclophosphamide43 49 1211.2VEGFA, HIF1A, TYMP
30bortezomib43 49 1211.2VEGFA, MYC, CDKN1A, HIF1A
31thymidine43 2410.2CDKN1A, MYC, HIF1A, TYMP
32mg 13243 5910.1VEGFA, HIF1A, CDKN1A, MYC
33arsenite43 2410.1CDKN1A, MYC, HIF1A, VEGFA
34n acetylcysteine439.1VEGFA, CDKN1A, MYC, HIF1A
35rapamycin439.1VEGFA, HIF1A, MYC, CDKN1A
36imatinib43 49 1211.1CDKN1A, VEGFA, MYC
37genistein43 28 59 2 24 1214.0VEGFA, HIF1A, MYC, CDKN1A
38gemcitabine43 49 1210.8VEGFA, TYMP, HIF1A, MYC, CDKN1A
39tamoxifen43 49 28 1211.8VEGFA, HIF1A, MYC, TYMP, CDKN1A
40ly294002438.8CDKN1A, MYC, TYMP, VEGFA, HIF1A
41doxorubicin43 49 1210.8MYC, CDKN1A, HIF1A, VEGFA, TYMP
42actinomycin d438.8MYC, VEGFA, CDKN1A, TYMP, HIF1A
43paraffin438.8HIF1A, MYC, CDKN1A, VEGFA, TYMP
44cisplatin43 49 59 1211.8TYMP, CDKN1A, MYC, HIF1A, VEGFA
45cycloheximide438.8MYC, CDKN1A, HIF1A, VEGFA, TYMP
46estrogen438.7CDKN1A, MYC, HIF1A, VEGFA, TYMP
47docetaxel43 49 59 1211.5VEGFA, HIF1A, SOX10, MYC, CDKN1A, TYMP
48paclitaxel43 49 1210.5CDKN1A, MYC, SOX10, HIF1A, VEGFA, TYMP
49vegf438.5CDKN1A, EPAS1, HIF1A, VEGFA, MYC, TYMP
50tyrosine437.6TYMP, VEGFA, SEC23IP, MYC, EPAS1, HIF1A

GO Terms for genes affiliated with Nodular Malignant Melanoma

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Cellular components related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00056548.9CDKN1A, MYC, EPAS1, HIF1A

Biological processes related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:004361910.0EPAS1, HIF1A
2digestive tract morphogenesisGO:004854610.0SOX10, HIF1A
3surfactant homeostasisGO:00431299.9VEGFA, EPAS1
4embryonic placenta developmentGO:00018929.9EPAS1, HIF1A
5neural crest cell migrationGO:00017559.9HIF1A, SOX10
6positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:00614199.8VEGFA, HIF1A
7dopaminergic neuron differentiationGO:00715429.8HIF1A, VEGFA
8positive regulation of fibroblast proliferationGO:00481469.8CDKN1A, MYC
9positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:00309499.8HIF1A, VEGFA
10positive regulation of mesenchymal cell proliferationGO:00020539.7MYC, VEGFA
11outflow tract morphogenesisGO:00031519.7VEGFA, HIF1A
12cell maturationGO:00484699.7VEGFA, SOX10, EPAS1
13lactationGO:00075959.6HIF1A, VEGFA
14regulation of gene expressionGO:00104689.6HIF1A, MYC
15positive regulation of neuroblast proliferationGO:00020529.6SOX10, HIF1A, VEGFA
16regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:00614189.5EPAS1, HIF1A, VEGFA
17positive regulation of endothelial cell proliferationGO:00019389.5HIF1A, VEGFA
18cellular response to hypoxiaGO:00714569.5EPAS1, HIF1A, VEGFA
19positive regulation of epithelial cell proliferationGO:00506799.4MYC, VEGFA
20response to hypoxiaGO:00016669.4VEGFA, HIF1A, EPAS1
21cellular iron ion homeostasisGO:00068799.3MYC, HIF1A
22angiogenesisGO:00015259.2EPAS1, HIF1A, VEGFA, TYMP
23negative regulation of apoptotic processGO:00430669.2CDKN1A, MYC, SOX10, VEGFA
24positive regulation of transcription from RNA polymerase II promoterGO:00459449.0VEGFA, HIF1A, EPAS1, MYC

Molecular functions related to Nodular Malignant Melanoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor bindingGO:00051619.5TYMP, VEGFA
2histone acetyltransferase bindingGO:00350359.4EPAS1, HIF1A
3protein heterodimerization activityGO:00469829.2EPAS1, HIF1A, VEGFA
4transcription factor bindingGO:00081349.0MYC, EPAS1, SOX10, HIF1A

Products for genes affiliated with Nodular Malignant Melanoma

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Sources for Nodular Malignant Melanoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet