MCID: NDL013
MIFTS: 42

Nodular Regenerative Hyperplasia malady

Liver diseases category

Summaries for Nodular Regenerative Hyperplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Nodular regenerative hyperplasia is a form of liver hyperplasia associated with portal hypertension. more...

MalaCards: Nodular Regenerative Hyperplasia, also known as nodular regenerative hyperplasia of the liver, is related to hypertension and hepatitis, and has symptoms including hepatocellular liver disease/hepatic failureand chronic arterial hypertension. An important gene associated with Nodular Regenerative Hyperplasia is GFER (growth factor, augmenter of liver regeneration), and among its related pathways are Pre-NOTCH Processing in Golgi and Post-transcriptional Silencing By Small RNAs. The compounds propylthiouracil and aspartate have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are vision/eye and endocrine/exocrine gland.

Aliases & Classifications for Nodular Regenerative Hyperplasia

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42NIH Rare Diseases, 48Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48

Aliases & Descriptions:

nodular regenerative hyperplasia 42
nodular regenerative hyperplasia of the liver 42 48
non-cirrhotic nodulation 42 48
non-cirrhotic nodular transformation 42
miliary hepatocellular adenomatosis 42
non-cirrhotic portal hypertension 42


External Ids:

ICD10 via Orphanet26 K76.8

Related Diseases for Nodular Regenerative Hyperplasia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Nodular Regenerative Hyperplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.3GGT1, NOTCH1
2hepatitis31.1GGT1
3inflammatory bowel disease30.9IL6, IL6R, TPMT, ITPA
4hepatocellular carcinoma30.8IL6, NOTCH1, GGT1, JAG1, PCNA, IL6R
5liver cirrhosis30.8GGT1, IL6R
6lupus erythematosus30.8APOH, F3
7systemic lupus erythematosus30.7APOH, IL6, F3, TPMT
8vasculitis30.5APOH, TPMT
9arthritis30.5IL6R, IL6
10cholestasis30.5JAG1, NOTCH2, GGT1
11pancreatitis30.5TPMT, IL6, GGT1, ITPA
12adenoma30.4IL6R, PCNA, GGT1
13sjogren's syndrome30.2APOH
14autoimmune hepatitis30.2TPMT
15multiple myeloma30.2IL6R, IL6
16diabetes mellitus30.2IL6, GGT1
17myeloma30.2NOTCH1, IL6R, IL6
18multiple sclerosis30.2JAG1, TPMT, IL6, IL6R
19ulcerative colitis30.2TPMT, IL6R, ITPA, IL6
20rheumatoid arthritis30.2APOH, IL6, IL6R, TPMT
21leukemia30.2IL6, NOTCH1, TPMT, IL6R
22connective tissue disease30.2IL6, F3, APOH
23breast cancer30.2NOTCH2, IL6R, JAG1, PCNA, NOTCH1
24vascular disease30.2F3, IL6, PCNA, APOH
25portal hypertension10.9
26liver disease10.8
27primary biliary cirrhosis10.6
28hepatitis a10.6
29peliosis hepatis10.5
30felty's syndrome10.5
31celiac disease10.5
32hepatopulmonary syndrome10.4
33common variable immunodeficiency10.4
34polyarteritis nodosa10.4
35glomerulonephritis10.4
36primary pulmonary hypertension10.3
37membranous glomerulonephritis10.3
38macroglobulinemia10.3
39myasthenia gravis10.3
40membranoproliferative glomerulonephritis10.3
41dyskeratosis congenita10.3
42hypersplenism10.3
43hypertensive retinopathy10.3
44graft versus host disease10.2
45crohn's disease10.2
46antiphospholipid syndrome10.2
47idiopathic pulmonary fibrosis10.2
48mucopolysaccharidosis i10.2
49visceral leishmaniasis10.2
50sickle cell anemia10.2

Graphical network of the top 20 diseases related to Nodular Regenerative Hyperplasia:



Diseases related to nodular regenerative hyperplasia

Clinical Features for Nodular Regenerative Hyperplasia

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Sources:
48Orphanet
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Symptoms:

48
  • hepatocellular liver disease/hepatic failure
  • chronic arterial hypertension

Drugs & Therapeutics for Nodular Regenerative Hyperplasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nodular Regenerative Hyperplasia

Drug clinical trials:

Search ClinicalTrials for Nodular Regenerative Hyperplasia

Search NIH Clinical Center for Nodular Regenerative Hyperplasia

Search CenterWatch for Nodular Regenerative Hyperplasia

Genetic Tests for Nodular Regenerative Hyperplasia

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Anatomical Context for Nodular Regenerative Hyperplasia

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32MalaCards
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MalaCards organs/tissues related to Nodular Regenerative Hyperplasia:

32
Liver

Animal Models for Nodular Regenerative Hyperplasia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nodular Regenerative Hyperplasia:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.8NOTCH2, JAG1
2MP:00053799.2IL6, IL6R, NOTCH1
3MP:00053699.0JAG1, ITPA, F3, NOTCH1
4MP:00107718.4JAG1, IL6, NOTCH1, GGT1
5MP:00053708.1JAG1, IL6, IL6R, NOTCH1, NOTCH2
6MP:00053767.9APOH, JAG1, NOTCH1, NOTCH2, GGT1, TPMT
7MP:00053847.4NOTCH2, NOTCH1, F3, IL6, PCNA, ITPA
8MP:00053876.7PCNA, IL6, IL6R, F3, NOTCH1, NOTCH2
9MP:00053976.5JAG1, ITPA, PCNA, IL6, F3, NOTCH1
10MP:00053786.1TPMT, JAG1, ITPA, PCNA, IL6, IL6R
11MP:00107686.1APOH, JAG1, ITPA, PCNA, IL6, F3

Publications for Nodular Regenerative Hyperplasia

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Genetic Variations for Nodular Regenerative Hyperplasia

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Expression for genes affiliated with Nodular Regenerative Hyperplasia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nodular Regenerative Hyperplasia

Search GEO for disease gene expression data for Nodular Regenerative Hyperplasia.

Pathways for genes affiliated with Nodular Regenerative Hyperplasia

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Sources:
53Reactome, 29KEGG, 51QIAGEN, 4Cell Signaling Technology, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Nodular Regenerative Hyperplasia according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7NOTCH2, NOTCH1
2
Hide members
9.7NOTCH2, NOTCH1
39.7NOTCH2, NOTCH1
4
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
9.5IL6R, IL6
5
Hide members
9.4NOTCH2, NOTCH1, JAG1
6
Hide members
9.4NOTCH2, NOTCH1, JAG1
79.4NOTCH2, NOTCH1, JAG1
89.4NOTCH2, NOTCH1, JAG1
99.4NOTCH2, NOTCH1, JAG1
109.4JAG1, NOTCH1, NOTCH2
11
Hide members
9.4JAG1, NOTCH1, NOTCH2
12
Hide members
9.4JAG1, NOTCH1, NOTCH2
13
Hide members
9.0IL6R, GFER, NOTCH1, NOTCH2
14
Hide members
8.4IL6, IL6R, GFER, NOTCH1, NOTCH2

Compounds for genes affiliated with Nodular Regenerative Hyperplasia

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Sources:
44Novoseek, 2BitterDB, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Nodular Regenerative Hyperplasia according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1112.5APOH
2aspartate4410.3NOTCH1
3heparin44 28 11 2413.3APOH
46 thioguanine4410.1TPMT, ITPA
5thiopurine4410.0TPMT, ITPA
66 mercaptopurine4410.0TPMT, ITPA
7kaolin449.9APOH, F3
8tocilizumab44 1110.9IL6, IL6R
9coumarins449.9F3, APOH
10inosine triphosphate44 2410.8TPMT, ITPA
11ptca449.8APOH
12warfarin44 49 11 2412.6APOH, F3, TPMT
13ticlopidine44 1110.5APOH, F3
14rituximab44 49 1111.4IL6R, IL6, APOH
15diethylnitrosamine449.4GGT1, PCNA
16dextran sulfate449.3F3, IL6, APOH
17hcec449.3GGT1, IL6
18arsenite44 2410.2GGT1, PCNA
19prednisolone44 28 1111.2APOH, IL6, IL6R, TPMT
20lycopene44 2410.1GGT1, PCNA
21endotoxin449.1APOH, IL6, F3
22cyclophosphamide44 49 1111.1APOH, PCNA, F3, TPMT
23vitamin b12449.1GGT1, PCNA, APOH
24betacarotene449.1APOH, PCNA, GGT1
25histamine44 28 2411.0TPMT, IL6R, IL6, PCNA
26cyclosporin a44 28 5910.9PCNA, IL6, IL6R, TPMT
27fibrinogen448.9APOH, IL6, IL6R, F3
28pentoxifylline44 119.9GGT1, F3, IL6
29tacrolimus44 49 1110.7TPMT, GGT1, F3, PCNA
30azathioprine44 49 2 1111.5APOH, ITPA, PCNA, GGT1, TPMT
31creatinine448.4APOH, IL6R, F3, GGT1, TPMT
32lactate448.4APOH, PCNA, IL6, GGT1
33retinoic acid44 249.2NOTCH1, F3, IL6R, IL6, PCNA
34dexamethasone44 49 28 1111.0GGT1, NOTCH1, IL6R, IL6, PCNA
35alanine448.0PCNA, IL6, F3, GGT1, TPMT
36vegf448.0APOH, PCNA, IL6, IL6R, F3, NOTCH1
37methotrexate44 49 119.5TPMT, GGT1, IL6R, IL6, PCNA, ITPA

GO Terms for genes affiliated with Nodular Regenerative Hyperplasia

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16Gene Ontology
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Cellular components related to Nodular Regenerative Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor complexGO:0058969.2IL6, IL6R
2cell surfaceGO:0099868.3NOTCH2, NOTCH1, F3, IL6R, APOH
3extracellular regionGO:0055768.1NOTCH2, NOTCH1, GFER, IL6R, IL6, JAG1

Biological processes related to Nodular Regenerative Hyperplasia according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1distal tubule developmentGO:07201710.0JAG1, NOTCH1
2negative regulation of stem cell differentiationGO:200073710.0NOTCH1, JAG1
3cell fate determinationGO:00170910.0NOTCH2, JAG1
4cardiac septum morphogenesisGO:06041110.0JAG1, NOTCH1
5response to muramyl dipeptideGO:03249510.0JAG1, NOTCH1
6neuronal stem cell maintenanceGO:0971509.9NOTCH1, JAG1
7hepatic immune responseGO:0023849.8IL6R, IL6
8negative regulation of collagen biosynthetic processGO:0329669.8IL6, IL6R
9neutrophil mediated immunityGO:0024469.7IL6, IL6R
10interleukin-6-mediated signaling pathwayGO:0701029.7IL6R, IL6
11pulmonary valve morphogenesisGO:0031849.7NOTCH2, NOTCH1, JAG1
12Notch signaling involved in heart developmentGO:0613149.7NOTCH2, NOTCH1, JAG1
13Notch receptor processingGO:0072209.7JAG1, NOTCH1, NOTCH2
14positive regulation of leukocyte chemotaxisGO:0026909.7IL6, IL6R
15bone remodelingGO:0468499.6NOTCH2, IL6
16positive regulation of JAK-STAT cascadeGO:0464279.5NOTCH1, IL6
17Notch signaling pathwayGO:0072199.5JAG1, NOTCH1, NOTCH2
18positive regulation of chemokine productionGO:0327229.5IL6, IL6R
19positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.5IL6R, IL6
20monocyte chemotaxisGO:0025489.4IL6, IL6R
21defense response to Gram-negative bacteriumGO:0508299.2IL6R, IL6

Molecular functions related to Nodular Regenerative Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3GFER, IL6, JAG1
2interleukin-6 receptor bindingGO:0051389.2IL6R, IL6

Products for genes affiliated with Nodular Regenerative Hyperplasia

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  • Antibodies
  • Proteins
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Sources for Nodular Regenerative Hyperplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet