MCID: NDL013
MIFTS: 49

Nodular Regenerative Hyperplasia malady

Categories: Genetic diseases, Rare diseases, Liver diseases

Aliases & Classifications for Nodular Regenerative Hyperplasia

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Aliases & Descriptions for Nodular Regenerative Hyperplasia:

Name: Nodular Regenerative Hyperplasia 48 68
Nodular Regenerative Hyperplasia of the Liver 48 54
Portal Hypertension, Non-Cirrhotic 52 70
Non-Cirrhotic Nodulation 48 54
Non-Cirrhotic Nodular Transformation 48
 
Miliary Hepatocellular Adenomatosis 48
Non-Cirrhotic Portal Hypertension 48
Portal Hypertension, Noncirrhotic 70
Nodular Hyperplasia 68
Ncph 70

Characteristics:

Orphanet epidemiological data:

54
nodular regenerative hyperplasia of the liver:
Inheritance: Not applicable; Age of onset: Adult

Classifications:

Orphanet: 54 
Rare hepatic diseases


External Ids:

Orphanet54 ORPHA48372
ICD10 via Orphanet31 K76.8
MedGen37 CN237800
MeSH39 D006975

Summaries for Nodular Regenerative Hyperplasia

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UniProtKB/Swiss-Prot:70 Portal hypertension, non-cirrhotic: An autosomal recessive disorder characterized by portal hypertension associated with hepatosplenomegaly, in absence of cirrhosis, extrahepatic diseases, and splanchnic venous thrombosis. Portal hypertension is defined by a portal venous system pressure that is at least 5 mm Hg higher than the pressure in the inferior vena cava. High pressure in the portal venous system leads to shunting of blood through vessels that are poorly suited to carrying large blood volumes, resulting in collateral circulation and splenomegaly. NCPH patients show normal liver function.

MalaCards based summary: Nodular Regenerative Hyperplasia, also known as nodular regenerative hyperplasia of the liver, is related to portal hypertension and hepatitis, and has symptoms including hypertension, hepatic failure and Array. An important gene associated with Nodular Regenerative Hyperplasia is DGUOK (Deoxyguanosine Kinase), and among its related pathways are Th2 Differentiation Pathway and Dorso-ventral axis formation. Affiliated tissues include liver, prostate and bone marrow, and related mouse phenotypes are embryo and cardiovascular system.

Wikipedia:71 Nodular regenerative hyperplasia is a form of liver hyperplasia associated with portal hypertension more...

Description from OMIM:52 617068

Related Diseases for Nodular Regenerative Hyperplasia

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Graphical network of the top 20 diseases related to Nodular Regenerative Hyperplasia:



Diseases related to nodular regenerative hyperplasia

Symptoms & Phenotypes for Nodular Regenerative Hyperplasia

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Clinical features from OMIM:

617068

Human phenotypes related to Nodular Regenerative Hyperplasia:

 64 54
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypertension64 hallmark (90%) HP:0000822
2 hepatic failure64 hallmark (90%) HP:0001399
3 portal hypertension54 Occasional (29-5%)
4 abnormality of the hepatic vasculature54 Very frequent (99-80%)

MGI Mouse Phenotypes related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.2EFNB2, F3, JAG1, NOTCH1, NOTCH2
2MP:00053858.8EFNB2, F3, ITPA, JAG1, NOTCH1, NOTCH2
3MP:00107718.7EFNB2, F3, ITPA, JAG1, NOTCH1, NOTCH2
4MP:00053698.6EFNB2, F3, ITPA, JAG1, NOTCH1, NOTCH2
5MP:00053848.4EFNB2, F3, GFER, ITPA, JAG1, NOTCH1
6MP:00053918.3EFNB2, F3, JAG1, NOTCH1, NOTCH2
7MP:00053977.3EFNB2, F3, ITPA, JAG1, NOTCH1, NOTCH2
8MP:00053786.9EFNB2, F3, GFER, ITPA, JAG1, NOTCH1
9MP:00107686.8EFNB2, F3, GFER, ITPA, JAG1, NOTCH1

Drugs & Therapeutics for Nodular Regenerative Hyperplasia

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Drugs for Nodular Regenerative Hyperplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Caffeineapproved, NutraceuticalPhase 438058-08-22519
Synonyms:
07E4FB58-FD79-4175-8E3D-05BF96954522
1,3,7-Trimethyl-2,6-dioxopurine
1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione
1,3,7-Trimethylpurine-2,6-dione
1,3,7-Trimethylxanthine
1,3,7-trimethyl-2,6-dioxopurine
1,3,7-trimethylpurine-2,6-dione
1,3,7-trimethylxanthine
1-3-7-TRIMETHYLXANTHINE
1-Methyl-Theobromine
1-methyltheobromine
137X
1gfz
1l5q
1l7x
27602_FLUKA
2a3b
3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
3,7-dihydro-1,3,7-trimethyl-1H-purine
5-26-13-00558 (Beilstein)
58-08-2
7-Methyl Theophylline
7-Methyltheophylline
7-methyltheophylline
71701-02-5
75035_FLUKA
95789-13-2
A.S.A. and Codeine Compound
AC-12774
AC1L1DV2
AC1Q3Z23
ACon1_000085
AI3-20154
AKOS000121334
Alert-Pep
Alert-pep
Anacin Maximum Strength
Anhydrous caffeine
Anhydrous caffeine (JP15)
Anhydrous caffeine (TN)
Anoquan
BIDD:ER0554
BIDD:GT0632
BIDD:PXR0172
BIM-0050216.0001
BRD-K02404261-001-02-7
BRD-K02404261-001-03-5
BRN 0017705
BSPBio_001921
Berlin-Chemie Brand of Caffeine
Bio-0579
Bio1_000473
Bio1_000962
Bio1_001451
Bristol-Myers Squibb Brand of Caffeine
C 0750
C07481
C0750_SIAL
C1778_SIAL
C2042
C6035_FLUKA
C6035_SIGMA
C7731_SIAL
C8960_SIAL
CCRIS 1314
CFF
CHEBI:27732
CHEMBL113
CID2519
CU-01000012617-3
Cafamil
Cafcit
Cafecon
Cafeina
Cafergot
Cafeína
Caffedrine
Caffedrine Caplets
Caffein
Caffeina
Caffeina [Italian]
Caffeine (USP)
Caffeine (natural)
Caffeine Pure
Caffeine [BAN:JAN]
Caffeine solution
Caffeine, Anhydrous
Caffeine, Monohydrate
Caffeine, Synthetic
Caffeine, anhydrous
Caffeine, synthetic
Caffeinum
Caffine
Cafipel
Caféine
Coffein
Coffein [German]
Coffeine
Coffeinum
Coffeinum N
Coffeinum Purrum
Compound 65
D002110
D00528
DB00201
DHC Plus
DHCplus
Darvon Compound
Darvon Compound-65
Dasin
Dexitac
Dexitac Stay Alert Stimulant
Dhc Plus
Diurex
DivK1c_000730
Durvitan
EINECS 200-362-1
EU-0100228
Eldiatric C
Enerjets
Ercatab
Esgic
Esgic-Plus
FEMA No. 2224
Femcet
Fioricet
Fiorinal
GlaxoSmithKline Brand of Caffeine
Guaranine
HMS1920I09
HMS2091O11
HMS502E12
HSDB 36
Hycomine
Hycomine Compound
I14-4386
 
IDI1_000730
Invagesic
Invagesic Forte
KBio1_000730
KBio2_001781
KBio2_004349
KBio2_006917
KBio3_001141
KBioGR_002325
KBioSS_001781
Keep Alert
Kofein
Kofein [Czech]
Koffein
Koffein [German]
L000155
LS-237
Lanorinal
Lopac-C-0750
Lopac0_000228
MEGxp0_001350
MLS001055341
MLS001056714
MLS001066409
Mateina
Mateína
Maximum Strength Snapback Stimulant Powders
Medigesic Plus
Merck dura Brand of Caffeine
Methyltheobromide
Methyltheobromine
Methylxanthine theophylline
Midol Maximum Strength
Migergot
Miudol
MolMap_000054
MolPort-000-730-850
Monohydrate Caffeine
Monomethyl Derivative of Theophylline
Monomethyl derivative of Theophylline
NCGC00015208-01
NCGC00015208-02
NCGC00015208-04
NCGC00015208-14
NCGC00090699-01
NCGC00090699-02
NCGC00090699-03
NCGC00090699-04
NCGC00090699-05
NCGC00090699-06
NCGC00090699-07
NCGC00090699-08
NCGC00090699-09
NCGC00168808-01
NCGC00168808-02
NCI-C02733
NCIOpen2_008255
NINDS_000730
NSC 5036
NSC5036
Natural Caffeinum
Nix Nap
No Doz
No-Doz
Nodaca
Nodoz Maximum Strength Caplets
Norgesic
Norgesic Forte
Organex
Orphengesic
Orphengesic Forte
P-A-C Analgesic Tablets
PDSP1_001016
PDSP1_001235
PDSP2_001000
PDSP2_001219
Passauer Brand of Caffeine
Pep-Back
Percoffedrinol N
Percutafeine
Phensal
Pierre Fabre Brand of Caffeine
Probes1_000150
Probes2_000128
Propoxyphene
Propoxyphene Compound 65
Propoxyphene Compound-65
Quick Pep
Quick-Pep
Refresh'n
Republic Drug Brand of Caffeine
SDCCGMLS-0064595.P001
SDCCGMLS-0064595.P002
SK 65 Compound
SK-65 Compound
SMR000326667
SPBio_001222
SPECTRUM1500155
STK177283
Seid Brand of Caffeine
Spectrum2_001261
Spectrum3_000321
Spectrum4_001782
Spectrum5_000423
Spectrum_001301
Stim
Synalgos-Dc
TNP00310
Thein
Theine
Theobromine ME
Theobromine Me
Theophylline ME
Theophylline Me
Theophylline, 7-methyl
Thompson Brand 1 of Caffeine
Thompson Brand 2 of Caffeine
Tirend
Tri-Aqua
Triad
UNII-3G6A5W338E
Ultra Pep-Back
Vivarin
W222402_ALDRICH
WLN: T56 BN DN FNVNVJ B1 F1 H1
Wake-Up
Wigraine
Xanthine, 1,3,7-trimethyl
ZINC00001084
bmse000206
cafeine
caffeine
caffenium
component of Cafergot
nchembio.243-comp7
nchembio.63-comp5
nchembio774-comp2
teina
teína
2AnalgesicsPhase 411287
3MesalaminePhase 416089-57-6
4Calcium, DietaryPhase 45525
5Antirheumatic AgentsPhase 410627
6Analgesics, Non-NarcoticPhase 46260
7Anti-Inflammatory AgentsPhase 410355
8Anti-Inflammatory Agents, Non-SteroidalPhase 44295
9Peripheral Nervous System AgentsPhase 422776
10Calcium SupplementNutraceuticalPhase 454
11
Propranololapproved, investigationalPhase 3216525-66-64946
Synonyms:
(+-)-Propranolol
(1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol
(R)-(+)-propranolol
(S)-(-)-PROPRANOLOL
1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol
1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane
1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol
1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol
1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol
1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol
1-Isopropylamino-3-(1-naphthyloxy)-2-propanol
1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol
1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
13013-17-7
2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- (9CI)
2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- (9CI)
3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol
4199-09-1
4199-10-4
525-66-6
AB00053537
AC1L1JA4
AC1Q1QBV
AC1Q1QC0
AKOS000588816
AY 64043
AY-20694
Anaprilin
Anapriline
Angilol
Apsolol
Avlocardyl
BPBio1_001040
BRD-A10070317-003-06-9
BSPBio_000944
BSPBio_002682
Bedranol
Beprane
Berkolol
Beta Neg
Beta-Neg
Beta-Propranolol
Beta-Tablinen
Beta-Timelets
Betachron
Betadren
Betalong
Bio-0732
Bio1_000367
Bio1_000856
Bio1_001345
C07407
C16H21NO2
CBDivE_006180
CCRIS 3082
CHEBI:8499
CHEMBL27
CID4946
Cardinol
Caridolol
Corpendol
D,L-Propranolol
D08443
DB00571
DL-Propranolol hydrochloride
Deralin
DivK1c_000023
Dl-Propranolol Hydrochloride
Dociton
Duranol
EINECS 208-378-0
EINECS 235-867-6
Efektolol
Elbrol
Etalong
Euprovasin
Frekven
HMS2090L21
Herzbase
ICI 45520
IDI1_000023
INDERIDE-40/25
INDERIDE-80/25
Ikopal
Inderal
Inderal La
Inderal hydrochloride
Inderalici
Inderex
Inderide
Inderol
Indobloc
InnoPranXL
 
Innopran XL
Intermigran
KBio1_000023
KBio2_002515
KBio2_005083
KBio2_007651
KBio3_001766
KBio3_001902
KBio3_002993
KBioGR_001347
KBioGR_001684
KBioGR_002515
KBioSS_002523
Kemi
Kemi S
L000679
LS-122410
LS-184129
Lopac0_000896
Migrastat
MolPort-001-794-623
NCGC00015798-07
NCGC00024690-02
NCGC00024690-03
NINDS_000023
NSC91523
Naprilin
Obsidan
Obzidan
Oposim
Oprea1_304193
PDSP1_000767
PDSP1_001607
PDSP1_001608
PDSP2_000755
PDSP2_001591
PDSP2_001592
Prano-Puren
Pranolol
Prestwick0_000952
Prestwick1_000952
Prestwick2_000952
Prestwick3_000952
Pronovan
Propanalol
Propanix
Propanolol
Propanolol [INN-Spanish]
Prophylux
Propranalol
Propranolol
Propranolol (INN)
Propranolol (TN)
Propranolol Hcl
Propranolol Hcl Intensol
Propranolol Hydrochloride
Propranolol [INN:BAN]
Propranololo
Propranololo [DCIT]
Propranololum
Propranololum [INN-Latin]
Propranur
Proprasylyt
Pylapron
R,S-Propranolol Hydrochloride
Racemic propranolol
Rapynogen
Reducor
Reducor Line
Reducor line
SPBio_001361
SPBio_001658
SPBio_003093
STK735510
Sagittol
Sawatal
Servanolol
Sloprolol
Spectrum2_001301
Spectrum2_001699
Spectrum3_000883
Spectrum3_001071
Spectrum4_000974
Spectrum4_001222
Spectrum5_000751
Sumial
Tesnol
UNII-9Y8NXQ24VQ
b-Propranolol
beta-Propranolol
cMAP_000071
etalong
propranolol
propranololo
β-Propranolol
12Neurotransmitter AgentsPhase 317734
13Vasodilator AgentsPhase 33438
14Antihypertensive AgentsPhase 34095
15Adrenergic AntagonistsPhase 31535
16Anti-Arrhythmia AgentsPhase 32969
17Adrenergic AgentsPhase 35140
18Adrenergic beta-AntagonistsPhase 31154
19
Epinephrineapproved, vet_approved93351-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
20
Etomidateapproved6333125-97-236339, 667484
Synonyms:
(+)-Ethyl 1-(alpha-methylbenzyl)imidazole-5-carboxylate
(+)-Etomidate
(+)-ethyl 1-(α-methylbenzyl)imidazole-5-carboxylate
(+)-etomidate
(R)-(+)-1-(alpha-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester
(R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
(d)-Etomidate
1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
1-(1-Phenylethyl)-imidazole-5-carboxylic acid, ethyl ester
1-(alpha-Methylbenzyl)-1H-imidazole-5-carboxylic acid ethyl ester
15301-65-2
1H-Imidazole-5-carboxylic acid, 1-((1R)-1-phenylethyl)-, ethyl ester
3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester
3-(1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester
33125-97-2
AC-5898
AC1L1VLF
AC1Q34BV
AC1Q64LP
AKOS000548952
Absele
Amidate
Amidate (TN)
Amidate (pharmaceutical)
Amidate, Etomidate
BAS 01947657
BRN 0665833
C07522
C14H16N2O2
CHEBI:129025
CHEMBL23731
CID36339
CPD000010931
D-Etomidate
D005045
D00548
 
DB00292
EINECS 251-385-9
Ethnor
Ethomidate
Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate
Etomidate
Etomidate (USAN/INN)
Etomidate [USAN:BAN:INN]
Etomidato
Etomidato [INN-Spanish]
Etomidatum
Etomidatum [INN-Latin]
Etomidic acid
HMS1571A04
HMS1612G10
HMS2093P17
Hypnomidate
LS-78232
MLS000034952
MLS001240191
MolPort-000-917-569
Prestwick0_001041
Prestwick1_001041
Prestwick2_001041
R 16659
R 26490
R-(+)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate
R-26490
R26490
Radenarcon
Radenarkon
S1329_Selleck
SAM002548930
SBB066197
SMR000010931
SPBio_002901
UNII-Z22628B598
ethyl 3-(1-phenylethyl)imidazole-4-carboxylate
21Liver Extracts3868
22Racepinephrine933
23Hormones, Hormone Substitutes, and Hormone Antagonists12767
24Epinephryl borate933
25glucocorticoids4920
26Hormones13979
27Hormone Antagonists12778
28Central Nervous System Depressants12806
29Hypnotics and Sedatives2485
30Mydriatics763
31Vasoconstrictor Agents2027
32Respiratory System Agents4818
33Bronchodilator Agents2856
34Anti-Asthmatic Agents3369
35Adrenergic alpha-Agonists1625
36Adrenergic Agonists2877
37Adrenergic beta-Agonists1640
38Anesthetics9001
39Anesthetics, Intravenous2406
40Anesthetics, General2787
41Autonomic Agents9774

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1Clinical Management of Childhood Intestinal Lymphoid Nodular HyperplasiaUnknown statusNCT01789294Phase 4
2Comparison of Endoscopic Variceal Ligation (EVL) With Propranolol in Non Cirrhotic Portal Hypertension (NCPH)CompletedNCT01000779Phase 3
3Contrast Enhanced Ultrasound For The Evaluation Of Focal Liver LesionsUnknown statusNCT01329458
4Risk Factors for Variceal Bleeding in Egyptian Patients With Non-Cirrhotic Portal HypertensionCompletedNCT02635815
5Quantitative Real-time Ultrasound Elastography for Characterisation of Liver TumorsCompletedNCT02156700
6Configuration of a New Prostate Disease Nomogram Predicting Prostate Biopsy OutcomeCompletedNCT01826617
7Superb Microvascular Imaging in Focal Nodular HyperplasiaRecruitingNCT02737865
8Natural History of Noncirrhotic Portal HypertensionRecruitingNCT02417740
9Mutations of Glucocorticoid Receptor in Bilateral Adrenal HyperplasiaRecruitingNCT02810496
10Contrast Enhanced (CE) Ultrasound and CE Computed Tomography or CE Magnetic Resonance Imaging in Liver MassesRecruitingNCT00828607
11Evaluation of Patients With Liver DiseaseRecruitingNCT00001971
1211C-Metomidate PET Versus Adrenal Vein Sampling in Primary AldosteronismActive, not recruitingNCT01567111
13Evaluation of Gastroesophageal Varices by Transnasal Endoscopy.Enrolling by invitationNCT02767206

Search NIH Clinical Center for Nodular Regenerative Hyperplasia

Genetic Tests for Nodular Regenerative Hyperplasia

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Anatomical Context for Nodular Regenerative Hyperplasia

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MalaCards organs/tissues related to Nodular Regenerative Hyperplasia:

36
Liver, Prostate, Bone marrow, T cells, Bone, B cells, Fetal liver

Publications for Nodular Regenerative Hyperplasia

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Articles related to Nodular Regenerative Hyperplasia:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
A case of idiopathic portal hypertension associated with nodular regenerative hyperplasia-like nodule of the liver and mixed connective tissue disease. (27151480)
2016
2
The Prevalence of Nodular Regenerative Hyperplasia in Inflammatory Bowel Disease Patients Treated with Thioguanine Is Not Associated with Clinically Significant Liver Disease. (27482972)
2016
3
Ataxia telangiectasia associated with nodular regenerative hyperplasia. (27671921)
2016
4
Epigastric Pain in a Patient With Nodular Regenerative Hyperplasia. (26827806)
2016
5
A case of nodular regenerative hyperplasia of the liver combined with toxic hepatitis. (25603855)
2015
6
P437. Short term prevalence of nodular regenerative hyperplasia of the liver in IBD patients treated with allopurinol-thiopurine combination therapy. (25717925)
2015
7
Prevalence and clinical significance of nodular regenerative hyperplasia in liver biopsies. (26415006)
2015
8
Hepatic Lesions Caused by Large Granular Lymphocyte Leukemia in Fischer 344 Rats: Similar Morphologic Features and Morphogenesis to Those of Nodular Regenerative Hyperplasia (NRH) in the Human Liver. (25903270)
2015
9
Development of nodular regenerative hyperplasia (NRH) with portal hypertension following the administration of oxaliplatin for the recurrence of colon cancer. (25748953)
2015
10
Indolent cytotoxic T cell lymphoproliferation associated with nodular regenerative hyperplasia: a common liver lesion in the context of common variable immunodeficiency disorder. (26493984)
2015
11
Nodular Regenerative Hyperplasia in Patients Undergoing Liver Resection for Colorectal Metastases After Chemotherapy: Risk Factors, Preoperative Assessment and Clinical Impact. (25845431)
2015
12
Diagnosing Nodular Regenerative Hyperplasia of the Liver Is Thwarted by Low Interobserver Agreement. (26054009)
2015
13
Nodular Regenerative Hyperplasia after Liver Transplantation Complicated with Inferior Vena Cava Stenosis: a Clue for Etiopathogenesis? (26405712)
2015
14
Drug-induced nodular regenerative hyperplasia. (24879987)
2014
15
Nodular Regenerative Hyperplasia Causing Portal Hypertension in a Patient with Chronic Graft versus Host Disease: Response to Sirolimus. (24434665)
2014
16
Nodular Regenerative Hyperplasia After Treatment With Trastuzumab Emtansine. (24778392)
2014
17
Human immunodeficiency virus and nodular regenerative hyperplasia of liver: A systematic review. (24653794)
2014
18
Hepatocellular carcinoma and nodular regenerative hyperplasia after chemotherapy for metastatic colorectal carcinoma. (24604623)
2014
19
Splenic artery ligation for severe oxaliplatin induced portal hypertension: a way to improve postoperative course and allow adjuvant chemotherapy for colorectal liver metastases.: Letter to editor: comment about "Nodular regenerative hyperplasia (NRH) complicating oxaliplatin chemotherapy in patients undergoing resection of colorectal liver metastases". (24613742)
2014
20
Nodular regenerative hyperplasia of the liver and cutaneous T-cell lymphoma: an unreported association. (25075662)
2014
21
Concurrent liver hodgkin lymphoma and nodular regenerative hyperplasia on an explanted liver with clinical diagnosis of alcoholic cirrhosis at university hospital fundaciA^n santa fe de bogotA!. (24511402)
2014
22
Hepatopulmonary syndrome associated with nodular regenerative hyperplasia after liver transplantation in a child. (24820314)
2014
23
Lengthy follow-up after liver transplantation for nodular regenerative hyperplasia in human immunodeficiency virus-infected patients: does the disease recur? (24296606)
2013
24
Nodular regenerative hyperplasia in a patient with generalized essential telangiectasia: Endotheliopathy as causal factor. (24273032)
2013
25
Nodular regenerative hyperplasia (NRH) complicating oxaliplatin chemotherapy in patients undergoing resection of colorectal liver metastases. (24370284)
2013
26
Portal Hypertension, Nodular Regenerative Hyperplasia of the Liver, and Obstructive Portal Venopathy due to Metastatic Breast Cancer. (23984149)
2013
27
Nodular regenerative hyperplasia related portal hypertension in a patient with hypogammaglobulinaemia. (23801845)
2013
28
Downregulation of the Endothelial Genes Notch1 and EphrinB2 in Patients with Nodular Regenerative Hyperplasia. (23870033)
2013
29
Review article: the association between nodular regenerative hyperplasia, inflammatory bowel disease and thiopurine therapy. (24099468)
2013
30
Nodular regenerative hyperplasia in common variable immunodeficiency. (23420139)
2013
31
Patients with nodular regenerative hyperplasia should be considered for hepatocellular carcinoma screening. (23607291)
2013
32
Unusual Nodular Regenerative Hyperplasia Mimicking Liver Metastases in CEUS. (24327467)
2013
33
Familial occurrence of nodular regenerative hyperplasia of the liver. (23287953)
2013
34
Nodular regenerative hyperplasia of the liver as a complication of long-standing systemic-onset juvenile idiopathic arthritis. (24315465)
2013
35
Hepatoportal sclerosis (obliterative portal venopathy) and nodular regenerative hyperplasia in a patient with myasthenia gravis: A case report and review of the published work. (23675894)
2013
36
Hepatic hemodynamics in 24 patients with nodular regenerative hyperplasia and symptomatic portal hypertension. (22554152)
2012
37
Noncirrhotic Portal Hypertension due to Nodular Regenerative Hyperplasia Treated with Surgical Portacaval Shunt. (22956964)
2012
38
Diffuse Muscular Pain, Skin Tightening, and Nodular Regenerative Hyperplasia Revealing Paraneoplastic Amyopathic Dermatomyositis due to Testicular Cancer. (23316407)
2012
39
Nodular regenerative hyperplasia of the liver and portal thrombosis. (22880521)
2012
40
Clinical analysis of 15 cases of liver nodular regenerative hyperplasia. (22707296)
2012
41
Portal hypertension in nodular regenerative hyperplasia: a mixed bag! (22823913)
2012
42
Interstitial pneumonia and nodular regenerative hyperplasia of the liver as initial manifestations of polyarteritis nodosa. (22449674)
2012
43
The role of nucleoside and nucleotide analogues in nodular regenerative hyperplasia in HIV-infected patients: a case control study. (21056493)
2011
44
Nodular regenerative hyperplasia and portal hypertension in a patient with coeliac disease. (22606433)
2011
45
Nodular regenerative hyperplasia: evolving concepts on underdiagnosed cause of portal hypertension. (21472097)
2011
46
Nodular regenerative hyperplasia of the liver: coral atoll-like lesions on ultrasound are characteristic in predisposed patients. (21697407)
2011
47
Incidence of nodular regenerative hyperplasia in inflammatory bowel disease patients treated with azathioprine. (20848502)
2011
48
A patient with Crohn's disease and portal hypertension. Nodular regenerative hyperplasia. (21276765)
2011
49
Liver transplantation for the treatment of nodular regenerative hyperplasia. (21601542)
2011
50
Nodular regenerative hyperplasia of the liver associated with didanosine persists for years even after its interruption. (22696691)
2011

Variations for Nodular Regenerative Hyperplasia

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UniProtKB/Swiss-Prot genetic disease variations for Nodular Regenerative Hyperplasia:

70
id Symbol AA change Variation ID SNP ID
1DGUOKp.Asn46SerVAR_076980

Clinvar genetic disease variations for Nodular Regenerative Hyperplasia:

5
id Gene Variation Type Significance SNP ID Assembly Location
1DGUOKNM_080916.2(DGUOK): c.137A> G (p.Asn46Ser)SNVPathogenicrs763615602GRCh37Chr 2, 74154174: 74154174

Expression for genes affiliated with Nodular Regenerative Hyperplasia

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Search GEO for disease gene expression data for Nodular Regenerative Hyperplasia.

Pathways for genes affiliated with Nodular Regenerative Hyperplasia

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GO Terms for genes affiliated with Nodular Regenerative Hyperplasia

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Cellular components related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1adherens junctionGO:00059129.7JAG1, NOTCH1

Biological processes related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1cardiac septum morphogenesisGO:006041110.3JAG1, NOTCH1
2distal tubule developmentGO:007201710.3JAG1, NOTCH1
3negative regulation of cell differentiationGO:004559610.3JAG1, NOTCH1
4negative regulation of neuron differentiationGO:004566510.3JAG1, NOTCH1
5negative regulation of stem cell differentiationGO:200073710.3JAG1, NOTCH1
6neuronal stem cell population maintenanceGO:009715010.3JAG1, NOTCH1
7positive regulation of Notch signaling pathwayGO:004574710.1JAG1, NOTCH1
8cell fate determinationGO:000170910.1JAG1, NOTCH2
9cellular response to hydrogen peroxideGO:007030110.1F3, PCNA
10positive regulation of aorta morphogenesisGO:190384910.1EFNB2, NOTCH1
11response to muramyl dipeptideGO:003249510.1JAG1, NOTCH1
12tissue regenerationGO:00422469.8NOTCH1, NOTCH2
13Notch signaling involved in heart developmentGO:00613149.8JAG1, NOTCH1, NOTCH2
14Notch signaling pathwayGO:00072199.7JAG1, NOTCH1, NOTCH2
15venous blood vessel morphogenesisGO:00488459.6EFNB2, NOTCH1
16animal organ morphogenesisGO:00098879.6EFNB2, JAG1, NOTCH2
17pulmonary valve morphogenesisGO:00031849.6JAG1, NOTCH1, NOTCH2

Molecular functions related to Nodular Regenerative Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Notch bindingGO:00051129.7JAG1, NOTCH1

Sources for Nodular Regenerative Hyperplasia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet