NOMA
MCID: NM001
MIFTS: 42

Noma (NOMA) malady

Categories: Rare diseases, Infectious diseases, Oral diseases

Aliases & Classifications for Noma

Aliases & Descriptions for Noma:

Name: Noma 12 50 56 42 14 69
Cancrum Oris 12 50 56
Oro-Facial Gangrene 50 69
Gangrenous Stomatitis 12
Noma Neonatorum 50
Oro-Facial Noma 50
Oral Gangrene 50

Characteristics:

Orphanet epidemiological data:

56
noma
Age of onset: Childhood;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9672
ICD10 33 A69.0
ICD9CM 35 528.1
MeSH 42 D009625
NCIt 47 C34852
Orphanet 56 ORPHA2700
UMLS via Orphanet 70 C0028271
ICD10 via Orphanet 34 A69.0
MESH via Orphanet 43 D009625
UMLS 69 C0028271

Summaries for Noma

MalaCards based summary : Noma, also known as cancrum oris, is related to acatalasemia and capillary leak syndrome, and has symptoms including oral manifestations An important gene associated with Noma is ARHGAP33 (Rho GTPase Activating Protein 33), and among its related pathways/superpathways are TGF-Beta Pathway and Development HGF signaling pathway. The drugs Progesterone and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are cellular and adipose tissue

Related Diseases for Noma

Graphical network of the top 20 diseases related to Noma:



Diseases related to Noma

Symptoms & Phenotypes for Noma

UMLS symptoms related to Noma:


oral manifestations

MGI Mouse Phenotypes related to Noma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 PTPN11 TNFRSF1A ALB ARHGAP1 IL18 MAPK7
2 adipose tissue MP:0005375 9.72 ARHGAP1 IL18 NGFR PTPN11 TNFRSF1A
3 digestive/alimentary MP:0005381 9.63 ALB IL18 MAPK7 NGFR PTPN11 TNFRSF1A
4 integument MP:0010771 9.5 ARHGAP1 IL18 MAPK7 NGFR PGR PTPN11
5 muscle MP:0005369 9.23 NGFR PGR PTPN11 TNFRSF1A ALB ARHGAP1

Drugs & Therapeutics for Noma

Drugs for Noma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
2
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757 53477783
3
Alogliptin Approved Phase 3 850649-61-5 11450633
4
Darbepoetin alfa Approved, Investigational Phase 3 11096-26-7, 209810-58-2
5
Metformin Approved Phase 3 657-24-9 14219 4091
6
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 6857599, 9887054 43805
7
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
8
Lapatinib Approved March 2007, Investigational Phase 3,Phase 2 231277-92-2, 388082-78-8 208908 9941095
9 Progestins Phase 3
10 Estradiol valerate Phase 3 979-32-8
11 Contraceptive Agents Phase 3
12 Hormone Antagonists Phase 3,Phase 2
13 Hormones Phase 3,Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
15 Estradiol 17 beta-cypionate Phase 3
16 Estradiol 3-benzoate Phase 3
17 Estrogens Phase 3,Phase 2
18 Polyestradiol phosphate Phase 3
19
protease inhibitors Phase 3
20 HIV Protease Inhibitors Phase 3
21 Hematinics Phase 3
22 Dipeptidyl-Peptidase IV Inhibitors Phase 3
23 Hypoglycemic Agents Phase 3
24 Incretins Phase 3
25 insulin Phase 3
26 Insulin, Globin Zinc Phase 3
27 Protein Kinase Inhibitors Phase 3,Phase 2
28 Antimetabolites Phase 3
29 Antimetabolites, Antineoplastic Phase 3
30
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
31
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
32 Steroid Synthesis Inhibitors Phase 2
33 Estrogen Antagonists Phase 2
34 Aromatase Inhibitors Phase 2
35 Imatinib Mesylate Phase 2 123596
36 Orange Nutraceutical Phase 2
37
Ranibizumab Approved 347396-82-1 459903
38
Exemestane Approved, Investigational 107868-30-4 60198
39
Letrozole Approved, Investigational 112809-51-5 3902
40
Anastrozole Approved, Investigational 120511-73-1 2187
41 Angiogenesis Inhibitors
42 Angiogenesis Modulating Agents

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 POPART'MUS: Prevention of Post Partum Relapses With Progestin and Estradiol in Multiple Sclerosis Unknown status NCT00127075 Phase 3
2 Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome Completed NCT00968708 Phase 3
3 RED-HF™ Trial - Reduction of Events With Darbepoetin Alfa in Heart Failure Trial Completed NCT00358215 Phase 3
4 Phase 3 Alogliptin Pediatric Study Recruiting NCT02856113 Phase 3
5 LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus Lapatinib Active, not recruiting NCT00680901 Phase 3
6 A Three-part Study of Eltrombopag in Thrombocytopenic Subjects With Myelodysplastic Syndromes or Acute Myeloid Leukemia Completed NCT01440374 Phase 2
7 Evaluation of Biomarkers Associated With Response to Subsequent Therapies in Subjects With HER2-Positive Metastatic Breast Cancer Recruiting NCT02213042 Phase 2
8 Study of Dasatinib vs Imatinib in Patients With Chronic Myeloid Leukemia (CML) Who Did Not Have Favorable Response to Imatinib Active, not recruiting NCT01593254 Phase 2
9 Development of Intravitreal Ranibizumab by Determining the Pathogenesis of Macular Edema With Retinal Vein Occlusion Unknown status NCT02169648
10 Fat Quality on Blood Lipids and Immune Response Completed NCT01679496
11 Comparison of Non-nutritive Suck (NNS) Measures to Clinical Estimates of Suck and Feeding Readiness in Preterm Infants Completed NCT01069731
12 Evaluating Dysphagia in Neonates With CHD Recruiting NCT03045757
13 Japanese Idiopathic Interstitial Pneumonias Registry Recruiting NCT03041623
14 A Study to Compare the Safety and Efficacy of an Aromatase Inhibitor in Combination With Lapatinib, Trastuzumab or Both for the Treatment of Hormone Receptor Positive, HER2+ Metastatic Breast Cancer Active, not recruiting NCT01160211

Search NIH Clinical Center for Noma

Cochrane evidence based reviews: noma

Genetic Tests for Noma

Anatomical Context for Noma

MalaCards organs/tissues related to Noma:

39
Bone

Publications for Noma

Articles related to Noma:

(show top 50) (show all 171)
id Title Authors Year
1
Noma in a child with acute leukaemia: when the 'face of poverty' finds an ally. ( 26740267 )
2016
2
People living with facial disfigurement after having had noma disease: A systematic review of the literature. ( 26837690 )
2016
3
Facing noma. ( 27788987 )
2016
4
SERUM LEVELS OF FA^BROBLAST GROWTH FACTOR-23, OSTEOPROTEGERA^N AND RECEPTOR ACTA^VATOR OF NUCLEAR FACTOR KAPPA B LA^GAND (RANKL) A^N PATA^ENTS WA^H PROLACTA^NOMA. ( 27849387 )
2016
5
A Review on Noma: A Recent Update. ( 26573028 )
2015
6
NOMA-GAP/ARHGAP33 regulates synapse development and autistic-like behavior in the mouse. ( 25869807 )
2015
7
Apnoeic oxygenation in noma patients. ( 25959184 )
2015
8
Paul Tessier facial reconstruction in 1970 Iran, a series of post-noma defects. ( 25817742 )
2015
9
Noma Neonatorum From Multidrug-Resistant Pseudomonas aeruginosa: An Underestimated Threat? ( 26407438 )
2015
10
Enabling Virtual Screening of Potent and Safer Antimicrobial Agents Against Noma: mtk-QSBER Model for Simultaneous Prediction of Antibacterial Activities and ADMET Properties. ( 25769968 )
2015
11
Serum soluble RAGE levels and carotid atherosclerosis: the Northern Manhattan Study (NOMAS). ( 25744702 )
2015
12
Noma: A disease of poverty presenting at an urban hospital in the United States. ( 27075129 )
2015
13
Cancrum Oris (Noma): The Role of Nutrition in Management. ( 28053869 )
2015
14
Bony fusion of the maxilla and mandible as a sequelae of noma: A rare case report. ( 26389063 )
2015
15
Noma: neglected, forgotten and a human rights issue. ( 25609756 )
2015
16
Noma affected children from niger have distinct oral microbial communities based on high-throughput sequencing of 16S rRNA gene fragments. ( 25474262 )
2014
17
Noma (cancrum oris) in the South African context. ( 23647162 )
2014
18
Plasma FGF23 and the risk of stroke: the Northern Manhattan Study (NOMAS). ( 24706015 )
2014
19
Noma and Cervicofacial Necrotizing Fasciitis: Clinicopathological Differentiation and an Illustrative Case Report of Noma. ( 24304357 )
2014
20
Acute gangrenous gingivitis--early stage noma. ( 24825288 )
2014
21
A noma case study. ( 25668873 )
2014
22
Noma in an immunocompromised patient. ( 24192747 )
2013
23
Noma: a neglected enigma. ( 25104148 )
2013
24
Noma (cancrum oris): a report of a case in a young AIDS patient with a review of the pathogenesis. ( 22907664 )
2013
25
Microarray analysis of microbiota of gingival lesions in noma patients. ( 24086784 )
2013
26
Special article: airway management in reconstructive surgery for noma (cancrum oris). ( 23733840 )
2013
27
Noma neonatorum. ( 23667229 )
2013
28
Risk factors for noma disease: a 6-year, prospective, matched case-control study in Niger. ( 25104163 )
2013
29
Noma in an Afghani child: a case report. ( 22381363 )
2012
30
Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin. ( 22810622 )
2012
31
First experiences with simultaneous skeletal and soft tissue reconstruction of noma-related facial defects. ( 21780014 )
2012
32
Bacterial diversity in oral samples of children in niger with acute noma, acute necrotizing gingivitis, and healthy controls. ( 22413030 )
2012
33
Gillies fan flap for the reconstruction of an upper lip defect caused by noma: case presentation. ( 23674921 )
2012
34
Association of serum soluble receptor for advanced glycation end-products with subclinical cerebrovascular disease: the Northern Manhattan Study (NOMAS). ( 21316677 )
2011
35
Acute necrotic stomatitis (noma) associated with methicillin-resistant Staphylococcus aureus infection in a newly acquired rhesus macaque (Macaca mulatta). ( 21332756 )
2011
36
Noma-like lesion in a patient with acute promyelocytic leukemia. ( 23049328 )
2011
37
Treatment of Noma: medical missions in Ethiopia. ( 20186205 )
2010
38
NOMA: A Preventable "Scourge" of African Children. ( 21243072 )
2010
39
One-stage operation for noma-induced bilateral ankylosis accompanied with mouth verrucous carcinoma - a case report and review of literature. ( 20936195 )
2010
40
A case and review of noma. ( 21200428 )
2010
41
Long-term results of trismus release in noma patients. ( 20541369 )
2010
42
Early outcome of noma surgery. ( 20332070 )
2010
43
CASE REPORT Journey of a Noma Face. ( 20628471 )
2010
44
Return of the waltzing flap in noma reconstructive surgery: revisiting the past in difficult circumstances. ( 19329369 )
2010
45
Lockjaw treatment after noma in the third world. ( 19816374 )
2009
46
Lipids and carotid plaque in the Northern Manhattan Study (NOMAS). ( 20028534 )
2009
47
Reconstruction of the maxilla with prefabricated scapular flaps in noma patients. ( 19483590 )
2009
48
Missing the forest for the trees in biomedical research: the example of noma. ( 18385341 )
2008
49
Recurrent noma (cancrum oris) in human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV and AIDS): report of a case. ( 18634964 )
2008
50
An oro-facial disease 'noma (cancrum oris)' in a Japanese monkey (Macaca fuscata): clinical signs, clinicopathological features, and response to treatment. ( 18822072 )
2008

Variations for Noma

Expression for Noma

Search GEO for disease gene expression data for Noma.

Pathways for Noma

Pathways related to Noma according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 CDC42 CXCL8 IL18 MAPK7 NGFR PTPN11
2
Show member pathways
12.55 CDC42 MAPK7 NGFR PTPN11
3
Show member pathways
12.54 CXCL8 IL18 PTPN11 TNFRSF1A
4
Show member pathways
12.23 CDC42 CXCL8 IL18 MAPK7 NGFR PTPN11
5 11.91 CDC42 MAPK7 PTPN11
6
Show member pathways
11.89 CDC42 MAPK7 TNFRSF1A
7
Show member pathways
11.87 CDC42 MAPK7 NGFR
8
Show member pathways
11.86 CXCL8 IL18 PTPN11
9 11.72 ARHGAP1 CDC42 MAPK7
10 11.69 CDC42 CXCL8 NGFR
11 11.61 CDC42 MAPK7 PTPN11
12 11.43 CDC42 CXCL8 IL18
13 11.42 CDC42 MAPK7 NGFR PTPN11
14
Show member pathways
11.22 CDC42 NGFR PTPN11
15 11.1 NGFR TNFRSF1A
16 11.09 ARHGAP1 CDC42
17 11.05 ARHGAP1 CDC42
18 11.02 CXCL8 IL18 TNFRSF1A
19 10.97 CDC42 MAPK7
20 10.84 IL18 PGR

GO Terms for Noma

Biological processes related to Noma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.62 CXCL8 IL18 NGFR TNFRSF1A
2 axon guidance GO:0007411 9.54 MAPK7 NGFR PTPN11
3 signal transduction GO:0007165 9.5 ARHGAP1 ARHGAP33 CXCL8 MAPK7 NGFR PGR
4 inflammatory response GO:0006954 9.46 CXCL8 IL18 NGFR TNFRSF1A
5 regulation of small GTPase mediated signal transduction GO:0051056 9.43 ARHGAP1 ARHGAP33 CDC42
6 neurotrophin TRK receptor signaling pathway GO:0048011 8.62 NGFR PTPN11

Molecular functions related to Noma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.73 ALB ARHGAP1 ARHGAP33 CDC42 CXCL8 IL18
2 tumor necrosis factor-activated receptor activity GO:0005031 8.62 NGFR TNFRSF1A

Sources for Noma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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