NOMA
MCID: NM001
MIFTS: 42

Noma (NOMA) malady

Infectious diseases, Oral diseases categories

Summaries for Noma

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32MalaCards
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MalaCards: Noma, also known as cancrum oris, is related to stomatitis and ankylosis. An important gene associated with Noma is MIR146A (microRNA 146a), and among its related pathways are MicroRNAs in cancer and Hyaluronan uptake and degradation. The compound hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Noma

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8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Oral diseases


Characteristics (Orphanet epidemiological data):

48
noma:
Age of onset: Childhood


Aliases & Descriptions:

noma 8 42 48 60
cancrum oris 8 42 48
oro-facial gangrene 42 60
gangrenous stomatitis 8
noma neonatorum 42
oro-facial noma 42
oral gangrene 42


External Ids:

Disease Ontology8 DOID:9672
NCIt39 C34852
MeSH34 D009625
ICD9CM27 528.1
MESH via Orphanet35 D009625
ICD10 via Orphanet26 A69.0
SNOMED-CT via Orphanet57 18116006
UMLS via Orphanet61 C0028271

Related Diseases for Noma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Noma:



Diseases related to noma

Clinical Features for Noma

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Drugs & Therapeutics for Noma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Noma

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Anatomical Context for Noma

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32MalaCards
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MalaCards organs/tissues related to Noma:

32
Bone

Animal Models for Noma or affiliated genes

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Publications for Noma

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50PubMed
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Articles related to Noma:

(show top 50)    (show all 151)
idTitleAuthorsYear
1
Noma and Cervicofacial Necrotizing Fasciitis: Clinicopathological Differentiation and an Illustrative Case Report of Noma. (24304357)
2014
2
Noma neonatorum. (23667229)
2013
3
Gillies fan flap for the reconstruction of an upper lip defect caused by noma: case presentation. (23674921)
2012
4
Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin. (22810622)
2012
5
Bacterial diversity in oral samples of children in niger with acute noma, acute necrotizing gingivitis, and healthy controls. (22413030)
2012
6
Association of serum soluble receptor for advanced glycation end-products with subclinical cerebrovascular disease: the Northern Manhattan Study (NOMAS). (21316677)
2011
7
One-stage operation for noma-induced bilateral ankylosis accompanied with mouth verrucous carcinoma - a case report and review of literature. (20936195)
2010
8
Return of the waltzing flap in noma reconstructive surgery: revisiting the past in difficult circumstances. (19329369)
2010
9
Early outcome of noma surgery. (20332070)
2010
10
Reconstruction of the maxilla with prefabricated scapular flaps in noma patients. (19483590)
2009
11
Leaf concentrate. Undernutrition. AIDS. The elimination of NOMA (Cancrum oris)? (19154641)
2009
12
Recurrent noma (cancrum oris) in human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV and AIDS): report of a case. (18634964)
2008
13
Noma (cancrum oris) in human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV and AIDS): clinical experience in Zimbabwe. (18280380)
2008
14
Primary and secondary procedures in functional and aesthetic reconstruction of noma-associated complex central facial defects. (17572555)
2007
15
What is your interpretation of the lesion? Noma. (16892719)
2006
16
Noma (orofacial gangrene). (16101886)
2005
17
Pseudomonas sepsis with Noma: an association? (16129930)
2005
18
Noma: an elegy to innocence and youth. (16101868)
2005
19
Noma: a forgotten disease. (12848465)
2003
20
Noma: an "infectious" disease of unknown aetiology. (12837347)
2003
21
Noma in a Nigerian adult. (12139171)
2002
22
Clinical experience in the treatment of noma sequelae. (11358102)
2001
23
International Association for Dental Research. Symposium on Noma. Nice, June 1998. (10522211)
1999
24
The World Health Organization initiative on noma. (10522217)
1999
25
Epidemiology of the incidence of oro-facial noma: a study of cases in Dakar, Senegal, 1981-1993. (10674669)
1999
26
Surgical treatment of noma. (10522216)
1999
27
The need for action against oro-facial gangrene (noma) (9438464)
1997
28
One-stage reconstruction for defects caused by cancrum oris (noma). (9015536)
1997
29
Noma: a review. (8988783)
1996
30
Noma: clinical and evolutive aspect. (8986049)
1996
31
Noma (Cancrum Oris) associated with Kwashiorkor: a case report and review of the literature. (8830877)
1996
32
Noma neonatorum: an unusual case of noma involving a full-term neonate. (1421918)
1992
33
CT findings in noma. (3392291)
1988
34
Noma neonatorum. (3116121)
1987
35
Noma. (3608577)
1987
36
Noma--a case report. (3842833)
1985
37
Herpetic primo-infection and noma-like ulceration in tropical Africa. (6307897)
1983
38
Noma. Report of two cases. (6581458)
1983
39
Noma in Saguinus oedipus: a report of 2 cases. (6816990)
1982
40
Cancrum oris (noma): past and present. (6938548)
1981
41
Noma neonatorum. (612627)
1977
42
Phospho- and glycosphingolipid metabolism in a rat neuri-noma clone (RN6) studied in tissue culture. (945936)
1976
43
Surgical repair of defects from noma (cancrum oris). (4586230)
1973
44
Noma. (5237068)
1967
45
NOMA: ITS ASSOCIATION WITH NUTRITIONAL DEPRIVATION AND PHYSICAL DEBILITATION. REPORT OF A CASE. (14176600)
1964
46
Noma in Viet-Nam. (13943108)
1962
47
Surgical treatment of sequelae of gangrenous stomatitis (noma). (13245450)
1955
48
Effect of cortisone and somatotrophic hormone upon the development of a noma-like condition in the rat. (13055242)
1953
49
Plastic and reconstructive surgery; facial deformity caused by deep cicatrix with disappearance of the gingivolabial sulcus due to syphilitic noma]. (13117391)
1953
50
Noma treated with penicillin. (20989840)
1946

Genetic Variations for Noma

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Expression for genes affiliated with Noma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Noma

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Pathways for genes affiliated with Noma

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29KEGG, 53Reactome
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Pathways related to Noma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7MIR221, MIR602, MIR122, MIR146A
2
Hide members
10.6HYAL2, HYAL1, HAS1
310.6HYAL2, HYAL1

Compounds for genes affiliated with Noma

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44Novoseek, 24HMDB
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Compounds related to Noma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hyaluronic acid44 2411.6HYAL2, HYAL1, HAS1

GO Terms for genes affiliated with Noma

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16Gene Ontology
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Cellular components related to Noma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.8HYAL1, MIA, ANG, WFDC2, KLK13

Biological processes related to Noma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1hyaluronan metabolic processGO:03021210.9HYAL2, HYAL1, HAS1
2cellular response to platelet-derived growth factor stimulusGO:03612010.8HAS1, HYAL1
3negative regulation of fibroblast migrationGO:01076410.8HAS1, HYAL2
4cellular response to UV-BGO:07149310.8HYAL2, HYAL1
5hyaluronan biosynthetic processGO:03021310.7HYAL1, HAS1
6response to reactive oxygen speciesGO:00030210.7HYAL1, HYAL2
7hyaluronan catabolic processGO:03021410.7HYAL2, HYAL1
8glycosaminoglycan metabolic processGO:03020310.6HYAL2, HYAL1, HAS1
9cellular response to interleukin-1GO:07134710.6HYAL2, HYAL1
10cellular response to fibroblast growth factor stimulusGO:04434410.5HYAL1, HYAL2
11response to antibioticGO:04667710.3HYAL2, HYAL1

Molecular functions related to Noma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hyaluronan synthase activityGO:05050110.6HYAL1, HAS1
2virus receptor activityGO:00161810.6HYAL2, HYAL1
3hyalurononglucosaminidase activityGO:00441510.5HYAL2, HYAL1
4Rac GTPase activator activityGO:03067510.3ARHGAP1, ARHGAP33

Products for genes affiliated with Noma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Noma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet