NOMA
MCID: NM001
MIFTS: 42

Noma (NOMA) malady

Infectious diseases, Oral diseases categories

Summaries for Noma

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32MalaCards
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MalaCards: Noma, also known as cancrum oris, is related to stomatitis and ankylosis. An important gene associated with Noma is MIR146A (microRNA 146a), and among its related pathways are MicroRNAs in cancer and Hyaluronan uptake and degradation. The compound hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Noma

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8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Oral diseases


Characteristics (Orphanet epidemiological data):

48
noma:
Age of onset: Childhood


Aliases & Descriptions:

noma 8 42 48 60
cancrum oris 8 42 48
oro-facial gangrene 42 60
gangrenous stomatitis 8
noma neonatorum 42
oro-facial noma 42
oral gangrene 42


External Ids:

Disease Ontology8 DOID:9672
NCIt39 C34852
MeSH34 D009625
ICD9CM27 528.1
MESH via Orphanet35 D009625
ICD10 via Orphanet26 A69.0
SNOMED-CT via Orphanet57 18116006
UMLS via Orphanet61 C0028271

Related Diseases for Noma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Noma:



Diseases related to noma

Clinical Features for Noma

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Drugs & Therapeutics for Noma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Noma

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Anatomical Context for Noma

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32MalaCards
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MalaCards organs/tissues related to Noma:

32
Bone

Animal Models for Noma or affiliated genes

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Publications for Noma

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50PubMed
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Articles related to Noma:

(show top 50)    (show all 151)
idTitleAuthorsYear
1
Noma in an immunocompromised patient. (24192747)
2013
2
Noma (cancrum oris): a report of a case in a young AIDS patient with a review of the pathogenesis. (22907664)
2013
3
Special article: airway management in reconstructive surgery for noma (cancrum oris). (23733840)
2013
4
First experiences with simultaneous skeletal and soft tissue reconstruction of noma-related facial defects. (21780014)
2012
5
Acute necrotic stomatitis (noma) associated with methicillin-resistant Staphylococcus aureus infection in a newly acquired rhesus macaque (Macaca mulatta). (21332756)
2011
6
A case and review of noma. (21200428)
2010
7
Long-term results of trismus release in noma patients. (20541369)
2010
8
Lipids and carotid plaque in the Northern Manhattan Study (NOMAS). (20028534)
2009
9
Missing the forest for the trees in biomedical research: the example of noma. (18385341)
2008
10
Noma in Laos: stigma of severe poverty in rural Asia. (18385344)
2008
11
Reconstruction of the maxilla with prefabricated scapular flaps in noma patients. (18520882)
2008
12
Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine. (17908484)
2007
13
The use of the pedicled supraclavicular flap in noma reconstructive surgery. (16816717)
2006
14
Noma. (16980106)
2006
15
Noma. (16980109)
2006
16
Noma: life cycle of a devastating sore - case report and literature review. (16324228)
2005
17
The child's noma in an hospital center in Burkina Faso : Clinical features and course. (19617073)
2005
18
Free flap transfer for closure and interposition-arthroplasty in noma defects of the lateral face associated with bony ankylosis. (15346015)
2004
19
Report of an infant with noma (cancrum oris). (15235191)
2004
20
An estimation of the incidence of noma in north-west Nigeria. (12753633)
2003
21
Noma: experiences with a microvascular approach under West African conditions. (12973208)
2003
22
Unusual presentation of NOMA: a case report. (15259930)
2003
23
Neonatal noma: infamous laryngeal involvement. (12709155)
2003
24
Noma-like gangrenous cheilitis in a child with cyclic neutropenia associated with myeloperoxidase deficiency. (14651574)
2003
25
New split scar cheek flap in reconstruction of noma sequelae. (12946369)
2003
26
Is noma neonatorum a presentation of ecthyma gangrenosum in the newborn? (11791113)
2002
27
Cancrum oris (noma): Level of education and occupation of parents of affected children in Nigeria. (11372157)
2000
28
Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child. (12608242)
2000
29
Noma (cancrum oris): questions and answers. (10522212)
1999
30
Noma: public health problem in Senegal and epidemilogical surveillance. (10522215)
1999
31
Living conditions of children at risk for noma: Nigerian experience. (10522214)
1999
32
Noma: report of a case resulting in bony ankylosis of the maxilla and mandible. (10578195)
1999
33
Radial forearm fasciocutaneous free flap as a solution in case of Noma. (10023764)
1999
34
Cancrum oris (noma) in a patient with acute lymphoblastic leukaemia. A complication of chemotherapy induced neutropenia. (9619095)
1998
35
Necrotising infection of the orofacial tissues in neonates (noma neonatorum). Case report. (9785441)
1998
36
Cancrum oris (noma) in children. (9550277)
1998
37
Noma (cancrum oris) in human immunodeficiency virus/acquired immune deficiency syndrome patients: report of eight cases. (8811814)
1996
38
Noma neonatorum. (8935271)
1995
39
Noma in an unusual case of perforated appendicitis with pneumoperitoneum. (3430301)
1987
40
Noma in children with severe combined immunodeficiency. (3020218)
1986
41
Noma in a full-term neonate. (3874741)
1985
42
Noma: report of three adult cases. (6586177)
1983
43
Cutaneous complications during measles in Zairian children: noma-like postmeasles ulcerations. (7174180)
1982
44
A case of noma with membrane on the throat. (7319601)
1981
45
Epidemiological and biochemical studies of necrotizing ulcerative gingivitis and noma (cancrum oris) in Nigerian children. (4627235)
1972
46
Noma: report of case. (5239452)
1968
47
Use of an anticholinergic drug in the closure of an orofacial fistula due to noma. Report of a case. (4381773)
1967
48
Noma. Report of a case. (13762416)
1961
49
Noma or gangrenous stomatitis; report of a case. (13370100)
1956
50
Case report; noma. (20292529)
1947

Genetic Variations for Noma

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Expression for genes affiliated with Noma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Noma

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Pathways for genes affiliated with Noma

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29KEGG, 53Reactome
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Pathways related to Noma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7MIR221, MIR602, MIR122, MIR146A
2
Hide members
10.6HYAL2, HYAL1, HAS1
310.6HYAL2, HYAL1

Compounds for genes affiliated with Noma

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44Novoseek, 24HMDB
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Compounds related to Noma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hyaluronic acid44 2411.6HYAL2, HYAL1, HAS1

GO Terms for genes affiliated with Noma

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16Gene Ontology
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Cellular components related to Noma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.8HYAL1, MIA, ANG, WFDC2, KLK13

Biological processes related to Noma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1hyaluronan metabolic processGO:03021210.9HAS1, HYAL1, HYAL2
2cellular response to platelet-derived growth factor stimulusGO:03612010.8HYAL1, HAS1
3negative regulation of fibroblast migrationGO:01076410.8HAS1, HYAL2
4cellular response to UV-BGO:07149310.8HYAL2, HYAL1
5hyaluronan biosynthetic processGO:03021310.7HYAL1, HAS1
6response to reactive oxygen speciesGO:00030210.7HYAL2, HYAL1
7hyaluronan catabolic processGO:03021410.7HYAL2, HYAL1
8glycosaminoglycan metabolic processGO:03020310.6HAS1, HYAL2, HYAL1
9cellular response to interleukin-1GO:07134710.6HYAL2, HYAL1
10cellular response to fibroblast growth factor stimulusGO:04434410.5HYAL2, HYAL1
11response to antibioticGO:04667710.3HYAL1, HYAL2

Molecular functions related to Noma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hyaluronan synthase activityGO:05050110.6HYAL1, HAS1
2virus receptor activityGO:00161810.6HYAL2, HYAL1
3hyalurononglucosaminidase activityGO:00441510.5HYAL2, HYAL1
4Rac GTPase activator activityGO:03067510.3ARHGAP1, ARHGAP33

Products for genes affiliated with Noma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Noma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet