NOMA
MCID: NM001
MIFTS: 37

Noma (NOMA) malady

Infectious, Oral categories

Summaries for Noma

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Noma, also known as cancrum oris, is related to stomatitis and ankylosis. An important gene associated with Noma is MIR146A (microRNA 146a), and among its related pathways are MicroRNAs in cancer and Hyaluronan uptake and degradation. The compound hyaluronic acid have been mentioned in the context of this disorder.

Aliases & Classifications for Noma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 49Orphanet, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Oral


Characteristics (Orphanet epidemiological data):

49
noma:
Age of onset: Childhood


Aliases & Descriptions:

noma 8 43 49 61
cancrum oris 8 43 49
oro-facial gangrene 43 61
gangrenous stomatitis 8
noma neonatorum 43
oro-facial noma 43
oral gangrene 43


External Ids:

Disease Ontology8 DOID:9672
NCIt40 C34852
MeSH35 D009625
ICD9CM27 528.1
MESH via Orphanet36 D009625
ICD10 via Orphanet26 A69.0
SNOMED-CT via Orphanet58 18116006
UMLS via Orphanet62 C0028271

Related Diseases for Noma

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Noma:



Diseases related to noma

Clinical Features for Noma

Drugs & Therapeutics for Noma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Noma

Drug clinical trials:

Search ClinicalTrials for Noma

Search NIH Clinical Center for Noma

Search CenterWatch for Noma

Genetic Tests for Noma

Anatomical Context for Noma

Animal Models for Noma or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Noma

Sources:
51PubMed
See all sources

Articles related to Noma:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
Microarray analysis of microbiota of gingival lesions in noma patients. (24086784)
2013
2
Gillies fan flap for the reconstruction of an upper lip defect caused by noma: case presentation. (23674921)
2012
3
Alleviating a Nomad's Anguish: Successful Treatment of a Case of Leg Mycetoma-A Case Report. (23243538)
2012
4
Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin. (22810622)
2012
5
Acute necrotic stomatitis (noma) associated with methicillin-resistant Staphylococcus aureus infection in a newly acquired rhesus macaque (Macaca mulatta). (21332756)
2011
6
Building centromeres: home sweet home or a nomadic existence? (20206496)
2010
7
One-stage operation for noma-induced bilateral ankylosis accompanied with mouth verrucous carcinoma - a case report and review of literature. (20936195)
2010
8
Long-term results of trismus release in noma patients. (20541369)
2010
9
Reconstruction of the maxilla with prefabricated scapular flaps in noma patients. (19483590)
2009
10
Recurrent noma (cancrum oris) in human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV and AIDS): report of a case. (18634964)
2008
11
The 'ngisipet' and trachoma prevention: solving the latrine problem in nomadic tribes. (18330442)
2007
12
Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine. (17908484)
2007
13
What is your interpretation of the lesion? Noma. (16892719)
2006
14
Noma--the ulcer of extreme poverty. (16421362)
2006
15
The use of the pedicled supraclavicular flap in noma reconstructive surgery. (16756246)
2006
16
Noma. (16980109)
2006
17
Noma (orofacial gangrene). (16101886)
2005
18
Temporal relationship between the occurrence of fresh noma and the timing of linear growth retardation in Nigerian children. (15655015)
2005
19
The child's noma in an hospital center in Burkina Faso : Clinical features and course. (19617073)
2005
20
Report of an infant with noma (cancrum oris). (15235191)
2004
21
Noma: a forgotten disease. (12848465)
2003
22
Noma: an "infectious" disease of unknown aetiology. (12837347)
2003
23
Noma (cancrum oris) associated with oral myiasis in an adult. (12945598)
2003
24
Noma: should we care? (12946367)
2003
25
Neonatal noma: infamous laryngeal involvement. (12709155)
2003
26
Noma-like gangrenous cheilitis in a child with cyclic neutropenia associated with myeloperoxidase deficiency. (14651574)
2003
27
New split scar cheek flap in reconstruction of noma sequelae. (12946369)
2003
28
Noma in a Nigerian adult. (12139171)
2002
29
Prevalent bacterial species and novel phylotypes in advanced noma lesions. (12037085)
2002
30
The World Health Organization initiative on noma. (10522217)
1999
31
Microbiological understandings and mysteries of noma (cancrum oris). (10522213)
1999
32
Cancrum oris (noma) in children. (9550277)
1998
33
Factors related to cervicitis in Qashghaee nomadic women of southern Iran. (9342804)
1997
34
One-stage reconstruction for defects caused by cancrum oris (noma). (9015536)
1997
35
Noma: a review. (8988783)
1996
36
Noma: clinical and evolutive aspect. (8986049)
1996
37
Noma (cancrum oris) in human immunodeficiency virus/acquired immune deficiency syndrome patients: report of eight cases. (8811814)
1996
38
Noma neonatorum. (8935271)
1995
39
Noma and noma neonatorum. (2311541)
1990
40
Noma in an unusual case of perforated appendicitis with pneumoperitoneum. (3430301)
1987
41
Noma--a case report. (3842833)
1985
42
Bacterial bone resorption in noma (gangrenous stomatitis). (6798179)
1981
43
Noma neonatorum: Its aetiopathogenesis. (79084)
1978
44
Phospho- and glycosphingolipid metabolism in a rat neuri-noma clone (RN6) studied in tissue culture. (945936)
1976
45
Surgical repair of defects from noma (cancrum oris). (4586230)
1973
46
Noma. (14033692)
1962
47
Noma. Report of a case. (13762416)
1961
48
Noma or gangrenous stomatitis; report of a case. (13370100)
1956
49
Effect of cortisone and somatotrophic hormone upon the development of a noma-like condition in the rat. (13055242)
1953
50
Noma treated with penicillin. (20989840)
1946

Genetic Variations for Noma

Expression for genes affiliated with Noma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Noma

Search GEO for disease gene expression data for Noma.

Pathways for genes affiliated with Noma

Sources:
30KEGG, 54Reactome
See all sources

Pathways related to Noma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7MIR221, MIR602, MIR122, MIR146A
2
Hide members
10.6HYAL2, HYAL1, HAS1
310.6HYAL2, HYAL1

Compounds for genes affiliated with Noma

Sources:
45Novoseek, 24HMDB
See all sources

Compounds related to Noma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hyaluronic acid45 2411.6HYAL2, HYAL1, HAS1

GO Terms for genes affiliated with Noma

Sources:
16Gene Ontology
See all sources

Cellular components related to Noma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.8HYAL1, MIA, ANG, WFDC2, KLK13

Biological processes related to Noma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1hyaluronan metabolic processGO:03021210.9HAS1, HYAL1, HYAL2
2cellular response to platelet-derived growth factor stimulusGO:03612010.8HYAL1, HAS1
3negative regulation of fibroblast migrationGO:01076410.8HAS1, HYAL2
4cellular response to UV-BGO:07149310.8HYAL2, HYAL1
5hyaluronan biosynthetic processGO:03021310.7HYAL1, HAS1
6response to reactive oxygen speciesGO:00030210.7HYAL2, HYAL1
7hyaluronan catabolic processGO:03021410.7HYAL2, HYAL1
8glycosaminoglycan metabolic processGO:03020310.6HAS1, HYAL2, HYAL1
9cellular response to interleukin-1GO:07134710.6HYAL2, HYAL1
10cellular response to fibroblast growth factor stimulusGO:04434410.5HYAL2, HYAL1
11response to antibioticGO:04667710.3HYAL1, HYAL2

Molecular functions related to Noma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hyaluronan synthase activityGO:05050110.6HYAL1, HAS1
2virus receptor activityGO:00161810.6HYAL2, HYAL1
3hyalurononglucosaminidase activityGO:00441510.5HYAL2, HYAL1
4Rac GTPase activator activityGO:03067510.3ARHGAP1, ARHGAP33

Products for genes affiliated with Noma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Noma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet