MCID: NM001
MIFTS: 42

Noma

Categories: Rare diseases, Infectious diseases, Oral diseases

Aliases & Classifications for Noma

MalaCards integrated aliases for Noma:

Name: Noma 12 50 56 42 14 69
Cancrum Oris 12 50 56
Oro-Facial Gangrene 50 69
Gangrenous Stomatitis 12
Noma Neonatorum 50
Oro-Facial Noma 50
Oral Gangrene 50

Characteristics:

Orphanet epidemiological data:

56
noma
Age of onset: Childhood;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9672
ICD10 33 A69.0
ICD9CM 35 528.1
MeSH 42 D009625
NCIt 47 C34852
Orphanet 56 ORPHA2700
MESH via Orphanet 43 D009625
UMLS via Orphanet 70 C0028271
ICD10 via Orphanet 34 A69.0
UMLS 69 C0028271

Summaries for Noma

MalaCards based summary : Noma, also known as cancrum oris, is related to acatalasemia and capillary leak syndrome, and has symptoms including oral manifestations An important gene associated with Noma is ARHGAP33 (Rho GTPase Activating Protein 33), and among its related pathways/superpathways are TGF-Beta Pathway and Development HGF signaling pathway. The drugs Estradiol and Progesterone have been mentioned in the context of this disorder. Affiliated tissues include myeloid, breast and heart, and related phenotypes are cellular and muscle

Related Diseases for Noma

Graphical network of the top 20 diseases related to Noma:



Diseases related to Noma

Symptoms & Phenotypes for Noma

UMLS symptoms related to Noma:


oral manifestations

MGI Mouse Phenotypes related to Noma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.56 PTN PTPN11 ALB ARHGAP1 IL18 MAPK7
2 muscle MP:0005369 9.17 ALB ARHGAP1 IL18 MAPK7 NGFR PGR

Drugs & Therapeutics for Noma

Drugs for Noma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
2
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
3
Alogliptin Approved Phase 3 850649-61-5 11450633
4
Darbepoetin alfa Approved, Investigational Phase 3 11096-26-7, 209810-58-2
5
Metformin Approved Phase 3 657-24-9 14219 4091
6
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
7
Exemestane Approved, Investigational Phase 3 107868-30-4 60198
8
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
9
Trastuzumab Approved, Investigational Phase 3 180288-69-1 9903
10
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
11
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
12
Lapatinib Approved March 2007, Investigational Phase 3 231277-92-2, 388082-78-8 208908 9941095
13 Contraceptive Agents Phase 3
14 Estradiol 17 beta-cypionate Phase 3
15 Estradiol 3-benzoate Phase 3
16 Estradiol valerate Phase 3 979-32-8
17 Estrogens Phase 3
18 Hormone Antagonists Phase 3
19 Hormones Phase 3
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
21 Polyestradiol phosphate Phase 3
22 Progestins Phase 3
23 Angiogenesis Inhibitors Phase 3
24 Dipeptidyl-Peptidase IV Inhibitors Phase 3
25 HIV Protease Inhibitors Phase 3
26 Hypoglycemic Agents Phase 3
27 Incretins Phase 3
28
protease inhibitors Phase 3
29 Hematinics Phase 3
30 insulin Phase 3
31 Insulin, Globin Zinc Phase 3
32 Aromatase Inhibitors Phase 3
33 Estrogen Antagonists Phase 3
34 Protein Kinase Inhibitors Phase 3
35 Steroid Synthesis Inhibitors Phase 3
36 Antimetabolites Phase 3
37 Antimetabolites, Antineoplastic Phase 3
38
Ranibizumab Approved 347396-82-1 459903
39 Angiogenesis Modulating Agents

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 POPART'MUS: Prevention of Post Partum Relapses With Progestin and Estradiol in Multiple Sclerosis Unknown status NCT00127075 Phase 3 nomegestrol acetate;estradiol;placebo
2 Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome Completed NCT00968708 Phase 3 Alogliptin;Placebo
3 RED-HF™ Trial - Reduction of Events With Darbepoetin Alfa in Heart Failure Trial Completed NCT00358215 Phase 3 Darbepoetin alfa;Placebo
4 Phase 3 Alogliptin Pediatric Study Recruiting NCT02856113 Phase 3 Alogliptin Benzoate;Placebo
5 A Study to Evaluate Pazopanib as an Adjuvant Treatment for Localized Renal Cell Carcinoma (RCC) Active, not recruiting NCT01235962 Phase 3 pazopanib;placebo
6 A Study to Compare the Safety and Efficacy of an Aromatase Inhibitor in Combination With Lapatinib, Trastuzumab or Both for the Treatment of Hormone Receptor Positive, HER2+ Metastatic Breast Cancer Active, not recruiting NCT01160211 Phase 3 lapatinib;trastuzumab;Aromatase inhibitor;lapatinib
7 LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus Lapatinib Active, not recruiting NCT00680901 Phase 3 Lapatinib;Placebo;Capecitabine;Oxaliplatin
8 A Three-part Study of Eltrombopag in Thrombocytopenic Subjects With Myelodysplastic Syndromes or Acute Myeloid Leukemia Completed NCT01440374 Phase 2 eltrombopag;placebo
9 Development of Intravitreal Ranibizumab by Determining the Pathogenesis of Macular Edema With Retinal Vein Occlusion Unknown status NCT02169648 ranibizumab
10 Fat Quality on Blood Lipids and Immune Response Completed NCT01679496
11 Stroke Incidence and Risk Factors in a Tri-ethnic Region Completed NCT03266952
12 Comparison of Non-nutritive Suck (NNS) Measures to Clinical Estimates of Suck and Feeding Readiness in Preterm Infants Completed NCT01069731
13 Evaluating Dysphagia in Neonates With CHD Recruiting NCT03045757
14 Supporting and Enhancing NICU Sensory Experiences (SENSE) Recruiting NCT03316547
15 Japanese Idiopathic Interstitial Pneumonias Registry Recruiting NCT03041623

Search NIH Clinical Center for Noma

Cochrane evidence based reviews: noma

Genetic Tests for Noma

Anatomical Context for Noma

MalaCards organs/tissues related to Noma:

39
Myeloid, Breast, Heart, Bone

Publications for Noma

Articles related to Noma:

(show top 50) (show all 182)
id Title Authors Year
1
Noma: Time to Address a Collective Moral Failure. ( 28115663 )
2017
2
Noma in an HIV infected patient in Guinea-Bissau: a case report. ( 28589415 )
2017
3
Management of noma: practice competence and knowledge among healthcare workers in a rural district of Zambia. ( 28678680 )
2017
4
Worst-Case Energy Efficiency Maximization in a 5G Massive MIMO-NOMA System. ( 28927019 )
2017
5
Noma: Overview of a Neglected Disease and Human Rights Violation. ( 28093536 )
2017
6
Noma as a complication of false teeth (Ebiino) extraction: a case report. ( 28412977 )
2017
7
Face of Noma and Extreme Poverty: Development of an Economic Index Derivable From Health Data. ( 28582299 )
2017
8
Noma in a patient with HIV. ( 28555591 )
2017
9
Cancrum oris (noma): An early sign of acute lymphoblastic leukemia relapse. ( 28799529 )
2017
10
Experimental demonstration of bidirectional NOMA-OFDMA visible light communications. ( 28241638 )
2017
11
Noma in a child with acute leukaemia: when the 'face of poverty' finds an ally. ( 26740267 )
2016
12
People living with facial disfigurement after having had noma disease: A systematic review of the literature. ( 26837690 )
2016
13
SERUM LEVELS OF FA^BROBLAST GROWTH FACTOR-23, OSTEOPROTEGERA^N AND RECEPTOR ACTA^VATOR OF NUCLEAR FACTOR KAPPA B LA^GAND (RANKL) A^N PATA^ENTS WA^H PROLACTA^NOMA. ( 27849387 )
2016
14
Facing noma. ( 27788987 )
2016
15
Serum soluble RAGE levels and carotid atherosclerosis: the Northern Manhattan Study (NOMAS). ( 25744702 )
2015
16
A Review on Noma: A Recent Update. ( 26573028 )
2015
17
NOMA-GAP/ARHGAP33 regulates synapse development and autistic-like behavior in the mouse. ( 25869807 )
2015
18
Apnoeic oxygenation in noma patients. ( 25959184 )
2015
19
Enabling Virtual Screening of Potent and Safer Antimicrobial Agents Against Noma: mtk-QSBER Model for Simultaneous Prediction of Antibacterial Activities and ADMET Properties. ( 25769968 )
2015
20
Noma Neonatorum From Multidrug-Resistant Pseudomonas aeruginosa: An Underestimated Threat? ( 26407438 )
2015
21
Cancrum Oris (Noma): The Role of Nutrition in Management. ( 28053869 )
2015
22
Noma: neglected, forgotten and a human rights issue. ( 25609756 )
2015
23
Noma: A disease of poverty presenting at an urban hospital in the United States. ( 27075129 )
2015
24
Bony fusion of the maxilla and mandible as a sequelae of noma: A rare case report. ( 26389063 )
2015
25
Paul Tessier facial reconstruction in 1970 Iran, a series of post-noma defects. ( 25817742 )
2015
26
Noma and Cervicofacial Necrotizing Fasciitis: Clinicopathological Differentiation and an Illustrative Case Report of Noma. ( 24304357 )
2014
27
Noma affected children from niger have distinct oral microbial communities based on high-throughput sequencing of 16S rRNA gene fragments. ( 25474262 )
2014
28
Plasma FGF23 and the risk of stroke: the Northern Manhattan Study (NOMAS). ( 24706015 )
2014
29
Acute gangrenous gingivitis--early stage noma. ( 24825288 )
2014
30
Noma (cancrum oris) in the South African context. ( 23647162 )
2014
31
A noma case study. ( 25668873 )
2014
32
Noma (cancrum oris): a report of a case in a young AIDS patient with a review of the pathogenesis. ( 22907664 )
2013
33
Noma: a neglected enigma. ( 25104148 )
2013
34
Special article: airway management in reconstructive surgery for noma (cancrum oris). ( 23733840 )
2013
35
Microarray analysis of microbiota of gingival lesions in noma patients. ( 24086784 )
2013
36
Noma neonatorum. ( 23667229 )
2013
37
Noma in an immunocompromised patient. ( 24192747 )
2013
38
Risk factors for noma disease: a 6-year, prospective, matched case-control study in Niger. ( 25104163 )
2013
39
Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin. ( 22810622 )
2012
40
Bacterial diversity in oral samples of children in niger with acute noma, acute necrotizing gingivitis, and healthy controls. ( 22413030 )
2012
41
First experiences with simultaneous skeletal and soft tissue reconstruction of noma-related facial defects. ( 21780014 )
2012
42
Noma in an Afghani child: a case report. ( 22381363 )
2012
43
Gillies fan flap for the reconstruction of an upper lip defect caused by noma: case presentation. ( 23674921 )
2012
44
Acute necrotic stomatitis (noma) associated with methicillin-resistant Staphylococcus aureus infection in a newly acquired rhesus macaque (Macaca mulatta). ( 21332756 )
2011
45
Association of serum soluble receptor for advanced glycation end-products with subclinical cerebrovascular disease: the Northern Manhattan Study (NOMAS). ( 21316677 )
2011
46
Noma-like lesion in a patient with acute promyelocytic leukemia. ( 23049328 )
2011
47
NOMA: A Preventable "Scourge" of African Children. ( 21243072 )
2010
48
CASE REPORT Journey of a Noma Face. ( 20628471 )
2010
49
Long-term results of trismus release in noma patients. ( 20541369 )
2010
50
Return of the waltzing flap in noma reconstructive surgery: revisiting the past in difficult circumstances. ( 19329369 )
2010

Variations for Noma

Expression for Noma

Search GEO for disease gene expression data for Noma.

Pathways for Noma

Pathways related to Noma according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 CDC42 CXCL8 IL18 MAPK7 NGFR PTN
2
Show member pathways
12.54 CDC42 MAPK7 NGFR PTPN11
3
Show member pathways
12.23 CDC42 CXCL8 IL18 MAPK7 NGFR PTN
4 11.91 CDC42 MAPK7 PTPN11
5
Show member pathways
11.87 CDC42 MAPK7 NGFR
6
Show member pathways
11.86 CXCL8 IL18 PTPN11
7 11.7 ARHGAP1 CDC42 MAPK7
8 11.66 CDC42 CXCL8 NGFR
9 11.58 CDC42 MAPK7 PTPN11
10 11.42 CDC42 MAPK7 NGFR PTPN11
11 11.37 CDC42 CXCL8 IL18
12
Show member pathways
11.12 CDC42 NGFR PTPN11
13 11.07 ARHGAP1 CDC42
14 11.03 ARHGAP1 CDC42
15 10.97 CDC42 MAPK7
16 10.84 IL18 PGR
17 10.69 CXCL8 PTN

GO Terms for Noma

Cellular components related to Noma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 8.62 ALB PTPN11

Biological processes related to Noma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon guidance GO:0007411 9.43 MAPK7 NGFR PTPN11
2 small GTPase mediated signal transduction GO:0007264 9.33 ARHGAP1 ARHGAP33 CDC42
3 regulation of small GTPase mediated signal transduction GO:0051056 9.13 ARHGAP1 ARHGAP33 CDC42
4 neurotrophin TRK receptor signaling pathway GO:0048011 8.62 NGFR PTPN11

Sources for Noma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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