NOMA
MCID: NM001
MIFTS: 52

Noma (NOMA) malady

Rare diseases, Infectious diseases, Oral diseases categories

Summaries for Noma

About this section
Sources:
34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MalaCards: Noma, also known as cancrum oris, is related to cerebrovascular disease and stomatitis. An important gene associated with Noma is NGFR (nerve growth factor receptor), and among its related pathways are Netrin-1 signaling and Cell adhesion Cadherin mediated cell adhesion. The compounds taxifolin and mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Noma

About this section
Sources:
9Disease Ontology, 44NIH Rare Diseases, 50Orphanet, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH, 41NCIt, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Oral diseases


Characteristics (Orphanet epidemiological data):

50
noma:
Age of onset: Childhood


Aliases & Descriptions:

noma 9 44 50 63
cancrum oris 9 44 50
oro-facial gangrene 44 63
gangrenous stomatitis 9
noma neonatorum 44
oro-facial noma 44
oral gangrene 44


External Ids:

Disease Ontology9 DOID:9672
ICD9CM28 528.1
MeSH36 D009625
NCIt41 C34852
MESH via Orphanet37 D009625
ICD10 via Orphanet27 A69.0
SNOMED-CT via Orphanet60 18116006
UMLS via Orphanet64 C0028271

Related Diseases for Noma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Noma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1cerebrovascular disease29.9APOB, APOA1
2stomatitis10.3
3ankylosis10.3
4necrotizing fasciitis10.3
5fasciitis10.3
6gingivitis10.2
7acquired immunodeficiency syndrome10.1
8neutropenia10.1
9leukostasis10.1MPO
10hydrops fetalis10.1PTPN11
11diabetic neuropathy10.1NGFR, AGER
12chylomicron retention disease10.1APOB
13rhinitis10.1ALB
14peripheral vascular disease10.1MPO, ALB
15chronic myelomonocytic leukemia10.0MPO, PTPN11
16neurofibromatosis10.0PTPN11, NGFR
17alcoholic hepatitis10.0ALB, APOA1
18skin disease10.0ALB, MPO
19acatalasia10.0
20leukopenia10.0ALB, MPO
21arcus senilis10.0APOA1, APOB
22norum disease10.0APOB, APOA1
23familial hypertriglyceridemia10.0APOA1, APOB
24hypobetalipoproteinemia10.0APOA1, APOB
25hyperlipidemia type 310.0APOA1, APOB
26hyperalphalipoproteinemia10.0APOB, APOA1
27abetalipoproteinemia10.0APOA1, APOB
28coronary stenosis10.0APOA1, APOB
29amyloidosis10.0APOA1, ALB, AGER
30hypersensitivity reaction type ii disease10.0ALB, MPO, PTPN11
31familial hyperlipidemia10.0APOA1, APOB
32hypoalphalipoproteinemia10.0APOB, APOA1
33peritonitis10.0MPO, ALB
34cystic fibrosis10.0NGFR, MPO, ALB
35tangier disease10.0APOB, APOA1
36familial hypercholesterolemia10.0APOB, APOA1
37periodontitis10.0MPO, AGER
38familial combined hyperlipidemia10.0APOB, APOA1
39arteriosclerosis10.0APOB, APOA1
40alzheimer's disease10.0NGFR, APOB, AGER
41appendicitis10.0
42measles10.0
43ecthyma10.0
44kwashiorkor10.0
45necrotizing ulcerative gingivitis10.0
46verrucous carcinoma10.0
47cheilitis10.0
48laryngitis10.0
49leukemia10.0
50myiasis10.0

Graphical network of the top 20 diseases related to Noma:



Diseases related to noma

Symptoms for Noma

About this section

Drugs & Therapeutics for Noma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Noma

Drug clinical trials:

Search ClinicalTrials for Noma

Search NIH Clinical Center for Noma

Search CenterWatch for Noma

Genetic Tests for Noma

About this section

Anatomical Context for Noma

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Noma:

34
Bone

Animal Models for Noma or affiliated genes

About this section
Sources:
38MGI
See all sources

Publications for Noma

About this section
Sources:
53PubMed
See all sources

Articles related to Noma:

(show top 50)    (show all 150)
idTitleAuthorsYear
1
Noma in an immunocompromised patient. (24192747)
2013
2
Noma (cancrum oris): a report of a case in a young AIDS patient with a review of the pathogenesis. (22907664)
2013
3
Gillies fan flap for the reconstruction of an upper lip defect caused by noma: case presentation. (23674921)
2012
4
Noma-like lesion in a patient with acute promyelocytic leukemia. (23049328)
2011
5
A case and review of noma. (21200428)
2010
6
One-stage operation for noma-induced bilateral ankylosis accompanied with mouth verrucous carcinoma - a case report and review of literature. (20936195)
2010
7
Reconstruction of the maxilla with prefabricated scapular flaps in noma patients. (19483590)
2009
8
An oro-facial disease 'noma (cancrum oris)' in a Japanese monkey (Macaca fuscata): clinical signs, clinicopathological features, and response to treatment. (18822072)
2008
9
Recurrent noma (cancrum oris) in human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV and AIDS): report of a case. (18634964)
2008
10
Missing the forest for the trees in biomedical research: the example of noma. (18385341)
2008
11
The use of the pedicled supraclavicular flap in noma reconstructive surgery. (16816717)
2006
12
Noma (cancrum oris). (16829299)
2006
13
What is your interpretation of the lesion? Noma. (16892719)
2006
14
The single and double-folded supraclavicular island flap as a new therapy option in the treatment of large facial defects in noma patients. (15861062)
2005
15
Noma (orofacial gangrene). (16101886)
2005
16
Noma: life cycle of a devastating sore - case report and literature review. (16324228)
2005
17
Temporal relationship between the occurrence of fresh noma and the timing of linear growth retardation in Nigerian children. (15655015)
2005
18
Comments on: "Role of individual ionic current systems in ventricular cells hypothesized by a model study" by Matsuoka S, Sarai N, Kuratomi S, Ono K, and Noma A. Jpn J Physiol 53: 105-123, 2003. (15667675)
2004
19
Free flap transfer for closure and interposition-arthroplasty in noma defects of the lateral face associated with bony ankylosis. (15346015)
2004
20
Noma: a forgotten disease. (12848465)
2003
21
An estimation of the incidence of noma in north-west Nigeria. (12753633)
2003
22
Noma: experiences with a microvascular approach under West African conditions. (12973208)
2003
23
Noma: an "infectious" disease of unknown aetiology. (12837347)
2003
24
Prefabricated superficial temporal fascia flap combined with a submental flap in noma surgery. (11884812)
2002
25
Noma in a Nigerian adult. (12139171)
2002
26
Is noma neonatorum a presentation of ecthyma gangrenosum in the newborn? (11791113)
2002
27
International Association for Dental Research. Symposium on Noma. Nice, June 1998. (10522211)
1999
28
The World Health Organization initiative on noma. (10522217)
1999
29
Isolation of Fusobacterium necrophorum from cancrum oris (noma). (9988340)
1999
30
Noma (cancrum oris): questions and answers. (10522212)
1999
31
Noma: public health problem in Senegal and epidemilogical surveillance. (10522215)
1999
32
Cancrum oris (noma) in a patient with acute lymphoblastic leukaemia. A complication of chemotherapy induced neutropenia. (9619095)
1998
33
Noma: a review. (8988783)
1996
34
Noma neonatorum: an unusual case of noma involving a full-term neonate. (1421918)
1992
35
Fiberoptically guided intubation in children with gangrenous stomatitis (noma). (2382859)
1990
36
Noma in children with severe combined immunodeficiency. (3020218)
1986
37
Noma: report of three adult cases. (6586177)
1983
38
Herpetic primo-infection and noma-like ulceration in tropical Africa. (6307897)
1983
39
Noma in a nonhuman primate. (6944671)
1981
40
Noma neonatorum: Its aetiopathogenesis. (79084)
1978
41
Phospho- and glycosphingolipid metabolism in a rat neuri-noma clone (RN6) studied in tissue culture. (945936)
1976
42
Surgical repair of defects from noma (cancrum oris). (4586230)
1973
43
Epidemiological and biochemical studies of necrotizing ulcerative gingivitis and noma (cancrum oris) in Nigerian children. (4627235)
1972
44
Use of an anticholinergic drug in the closure of an orofacial fistula due to noma. Report of a case. (4381773)
1967
45
NOMA: ITS ASSOCIATION WITH NUTRITIONAL DEPRIVATION AND PHYSICAL DEBILITATION. REPORT OF A CASE. (14176600)
1964
46
Effect of cortisone and somatotrophic hormone upon the development of a noma-like condition in the rat. (13055242)
1953
47
Two cases of noma sequelae treated with scalp flaps. (13003564)
1952
48
A review of noma; report of a case treated with aureomycin. (14863869)
1951
49
Case report; noma. (20292529)
1947
50
Noma treated with penicillin. (20989840)
1946

Variations for Noma

About this section

Expression for genes affiliated with Noma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Noma

Search GEO for disease gene expression data for Noma.

Pathways for genes affiliated with Noma

About this section
Sources:
51PathCards, 56Reactome, 61Thomson Reuters, 39NCBI BioSystems Database, 31KEGG, 52PharmGKB, 13EMD Millipore, 54QIAGEN
See all sources

Pathways related to Noma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CDC42, PTPN11
29.8PTPN11, CDC42
3
Show member pathways
Vitamin B12 Metabolism39
9.8MPO, APOA1
4
Show member pathways
9.7APOB, APOA1
5
Show member pathways
9.7APOB, APOA1
69.7APOA1, APOB
79.7ARHGAP1, CDC42
89.7CDC42, ARHGAP1
99.6ALB, APOA1
109.6ALB, APOB
11
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.6CDC42, PTPN11, NGFR
12
Show member pathways
9.6NGFR, PTPN11, CDC42
139.6CDC42, PTPN11, NGFR
149.5AGER, MPO, APOB
15
Show member pathways
9.4ARHGAP1, CDC42, NGFR
16
Show member pathways
9.2ALB, APOB, APOA1
17
Show member pathways
9.2ALB, APOB, APOA1
189.2APOA1, APOB, ALB
19
Show member pathways
thioredoxin pathway39
8.9ALB, MPO, APOB, APOA1
20
Show member pathways
8.8CDC42, ARHGAP1, ARHGAP33
21
Show member pathways
8.6PTPN11, APOA1, APOB, ALB, CDC42
22
Show member pathways
7.4NGFR, PTPN11, APOA1, APOB, CDC42, ARHGAP1

Compounds for genes affiliated with Noma

About this section
Sources:
46Novoseek, 12DrugBank, 25HMDB, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience
See all sources

Compounds related to Noma according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1taxifolin4610.2MPO, APOB
2mechlorethamine4610.1APOA1, MPO
3n(epsilon)-(carboxymethyl)lysine4610.1AGER, ALB
4maxepa4610.1APOB, APOA1
5polyethylene glycol 60004610.1APOB, APOA1
6lynestrenol4610.1APOB, APOA1
7colestipol4610.1APOB, APOA1
8tolmetin46 1211.1MPO, ALB
9aopp4610.0MPO, ALB
10campesterol46 2511.0APOB, APOA1
11chloramine t4610.0MPO, APOA1
12pentosidine4610.0AGER, ALB
13iohexol469.9ALB, APOA1
14fenofibric acid46 3010.9APOB, APOA1
15desogestrel46 1210.9APOA1, APOB
16ampicillin46 1210.8ALB, MPO
17metformin46 52 1211.8AGER, APOB, APOA1
18gestodene46 1210.8APOA1, APOB
19lovastatin46 52 62 30 1213.7APOA1, APOB, CDC42
20ciprofibrate46 3010.7APOA1, APOB
21retinyl palmitate46 2510.7APOB, APOA1
22polyethylene glycol469.7ALB, MPO, APOA1
23fructosamine46 2510.7APOA1, APOB, ALB
24rosuvastatin46 52 30 1212.6APOA1, APOB, ALB
25captopril46 62 52 30 1213.6APOA1, APOB, ALB
26superoxide46 2510.6NGFR, MPO, CDC42, AGER
27prednisolone46 30 1211.6ALB, MPO, APOB
28alpha tocopherol469.6ALB, APOB, APOA1
29palmitate469.5ALB, APOB, APOA1
30homocysteine46 2510.5APOA1, APOB, ALB
31indomethacin46 30 62 1212.4NGFR, APOA1, MPO, ALB
32uric acid46 2510.4AGER, ALB, APOB, APOA1
33nadph46 2510.4NGFR, PTPN11, MPO, CDC42, AGER
34dextran sulfate469.4ALB, MPO, APOB, APOA1
35kininogen469.4APOA1, APOB, MPO, ALB
36vitamin b12469.4ALB, MPO, APOB, APOA1
37choline46 25 1211.3APOB, APOA1, NGFR
38acetylcholine46 52 30 25 1213.3NGFR, PTPN11, APOA1, MPO, CDC42
39fibrinogen469.3PTPN11, APOA1, APOB, ALB
40lactate469.2APOA1, APOB, MPO, ALB
41glutamate469.2NGFR, PTPN11, APOA1, APOB, CDC42
42heparin46 30 25 1212.1AGER, ALB, MPO, APOB
43creatinine469.1APOA1, APOB, MPO, ALB, AGER
44vegf469.0NGFR, PTPN11, APOB, MPO, CDC42, AGER
45alanine469.0CDC42, ALB, APOB, APOA1, PTPN11
46thyroxine46 259.9APOA1, APOB, ALB
47cholesterol46 30 25 1211.8NGFR, APOA1, APOB, ALB, CDC42, AGER
48serine468.6NGFR, PTPN11, APOA1, APOB, MPO, CDC42
49glucose468.5NGFR, PTPN11, APOA1, APOB, ALB, CDC42
50lipid468.5NGFR, PTPN11, APOA1, APOB, ALB, CDC42

GO Terms for genes affiliated with Noma

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Noma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:0716829.8APOB, APOA1
2very-low-density lipoprotein particleGO:0343619.6APOB, APOA1
3extracellular vesicular exosomeGO:0700628.5ARHGAP1, CDC42, ALB, MPO, APOA1
4extracellular regionGO:0055768.4NGFR, APOA1, APOB, ALB, AGER
5cytosolGO:0058297.5ARHGAP33, NGFR, PTPN11, APOA1, APOB, CDC42
6plasma membraneGO:0058867.5NGFR, APOA1, APOB, CDC42, AGER, ARHGAP1

Biological processes related to Noma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particle remodelingGO:0343749.9MPO, APOB
2lipoprotein biosynthetic processGO:0421589.9APOB, APOA1
3hair follicle morphogenesisGO:0310699.8NGFR, CDC42
4cholesterol transportGO:0303019.8APOB, APOA1
5cholesterol effluxGO:0333449.7APOB, APOA1
6lipoprotein metabolic processGO:0421579.4APOA1, APOB, ALB
7tRNA processingGO:0080339.0TRMT12, TYW3
8regulation of small GTPase mediated signal transductionGO:0510568.9CDC42, ARHGAP1, ARHGAP33
9small GTPase mediated signal transductionGO:0072648.8ARHGAP33, ARHGAP1, CDC42
10blood coagulationGO:0075968.8CDC42, ALB, APOB, APOA1, PTPN11

Molecular functions related to Noma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apolipoprotein A-I receptor bindingGO:0341919.8CDC42, APOA1
2cholesterol transporter activityGO:0171279.4APOB, APOA1
3Rac GTPase activator activityGO:0306759.1ARHGAP33, ARHGAP1
4protein bindingGO:0055156.6NGFR, PTPN11, APOA1, APOB, ALB, CDC42

Products for genes affiliated with Noma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Noma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet