MCID: NM001
MIFTS: 44

Noma malady

Rare diseases, Infectious diseases, Oral diseases categories

Aliases & Classifications for Noma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 47Orphanet, 60UMLS, 27ICD9CM, 33MeSH, 55SNOMED-CT, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Noma, Aliases & Descriptions:

Name: Noma 9 41 47 60
Cancrum Oris 9 41 47
Oro-Facial Gangrene 41 60
Gangrenous Stomatitis 9
 
Noma Neonatorum 41
Oro-Facial Noma 41
Oral Gangrene 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Oral diseases


Characteristics (Orphanet epidemiological data):

47
noma:
Age of onset: Childhood


External Ids:

Disease Ontology9 DOID:9672
ICD9CM27 528.1
MeSH33 D009625
NCIt38 C34852
Orphanet47 2700
MESH via Orphanet34 D009625
ICD10 via Orphanet26 A69.0
UMLS via Orphanet61 C0028271

Summaries for Noma

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MalaCards based summary: Noma, also known as cancrum oris, is related to cerebrovascular disease and leukostasis. An important gene associated with Noma is NGFR (nerve growth factor receptor), and among its related pathways are Netrin-1 signaling and Cell adhesion Cadherin mediated cell adhesion. The compounds taxifolin and mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are renal/urinary system and integument.

Related Diseases for Noma

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Diseases related to Noma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1cerebrovascular disease29.9APOB, APOA1
2leukostasis10.4MPO
3hydrops fetalis10.4PTPN11
4stomatitis10.3
5diabetic neuropathy10.3NGFR, AGER
6chylomicron retention disease10.3APOB
7ankylosis10.3
8necrotizing fasciitis10.3
9fasciitis10.3
10gingivitis10.3
11rhinitis10.3ALB
12peripheral vascular disease10.2MPO, ALB
13chronic myelomonocytic leukemia10.2MPO, PTPN11
14neurofibromatosis10.2NGFR, PTPN11
15neutropenia10.1
16acquired immunodeficiency syndrome10.1
17alcoholic hepatitis10.1APOA1, ALB
18skin disease10.1ALB, MPO
19leukopenia10.0MPO, ALB
20acatalasemia10.0
21arcus senilis10.0APOA1, APOB
22norum disease10.0APOA1, APOB
23hypertriglyceridemia10.0APOA1, APOB
24hypobetalipoproteinemia10.0APOB, APOA1
25hyperlipidemia type 310.0APOB, APOA1
26hyperalphalipoproteinemia10.0APOA1, APOB
27abetalipoproteinemia10.0APOA1, APOB
28coronary stenosis10.0APOB, APOA1
29amyloidosis10.0AGER, APOA1, ALB
30hypersensitivity reaction type ii disease10.0ALB, MPO, PTPN11
31familial hyperlipidemia10.0APOA1, APOB
32hypoalphalipoproteinemia10.0APOA1, APOB
33myeloperoxidase deficiency10.0
34leukemia10.0
35severe combined immunodeficiency10.0
36appendicitis10.0
37measles10.0
38ecthyma10.0
39kwashiorkor10.0
40necrotizing ulcerative gingivitis10.0
41verrucous carcinoma10.0
42cheilitis10.0
43laryngitis10.0
44myiasis10.0
45peritonitis10.0MPO, ALB
46cystic fibrosis10.0ALB, NGFR, MPO
47tangier disease10.0APOB, APOA1
48hypercholesterolemia, familial10.0APOB, APOA1
49periodontitis10.0MPO, AGER
50hyperlipidemia, familial combined10.0APOB, APOA1

Graphical network of the top 20 diseases related to Noma:



Diseases related to noma

Symptoms for Noma

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Drugs & Therapeutics for Noma

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Drug clinical trials:

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Genetic Tests for Noma

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Anatomical Context for Noma

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MalaCards organs/tissues related to Noma:

31
Bone

Animal Models for Noma or affiliated genes

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Publications for Noma

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Articles related to Noma:

(show top 50)    (show all 159)
idTitleAuthorsYear
1
Paul Tessier facial reconstruction in 1970 Iran, a series of post-noma defects. (25817742)
2015
2
Acute gangrenous gingivitis--early stage noma. (24825288)
2014
3
Noma: a neglected enigma. (25104148)
2013
4
Noma in an immunocompromised patient. (24192747)
2013
5
Noma (cancrum oris): a report of a case in a young AIDS patient with a review of the pathogenesis. (22907664)
2013
6
Gillies fan flap for the reconstruction of an upper lip defect caused by noma: case presentation. (23674921)
2012
7
Noma-like lesion in a patient with acute promyelocytic leukemia. (23049328)
2011
8
A case and review of noma. (21200428)
2010
9
Reconstruction of the maxilla with prefabricated scapular flaps in noma patients. (19483590)
2009
10
An oro-facial disease 'noma (cancrum oris)' in a Japanese monkey (Macaca fuscata): clinical signs, clinicopathological features, and response to treatment. (18822072)
2008
11
Recurrent noma (cancrum oris) in human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV and AIDS): report of a case. (18634964)
2008
12
Missing the forest for the trees in biomedical research: the example of noma. (18385341)
2008
13
The use of the pedicled supraclavicular flap in noma reconstructive surgery. (16816717)
2006
14
Response to Taguchi and Noma on "relationship between directionality and orientation in drawings by young children and adults. (16671630)
2006
15
Noma (cancrum oris). (16829299)
2006
16
What is your interpretation of the lesion? Noma. (16892719)
2006
17
The single and double-folded supraclavicular island flap as a new therapy option in the treatment of large facial defects in noma patients. (15861062)
2005
18
Noma (orofacial gangrene). (16101886)
2005
19
Noma: life cycle of a devastating sore - case report and literature review. (16324228)
2005
20
Temporal relationship between the occurrence of fresh noma and the timing of linear growth retardation in Nigerian children. (15655015)
2005
21
Comments on: "Role of individual ionic current systems in ventricular cells hypothesized by a model study" by Matsuoka S, Sarai N, Kuratomi S, Ono K, and Noma A. Jpn J Physiol 53: 105-123, 2003. (15667675)
2004
22
Free flap transfer for closure and interposition-arthroplasty in noma defects of the lateral face associated with bony ankylosis. (15346015)
2004
23
Noma: a forgotten disease. (12848465)
2003
24
An estimation of the incidence of noma in north-west Nigeria. (12753633)
2003
25
Noma: experiences with a microvascular approach under West African conditions. (12973208)
2003
26
Noma: an "infectious" disease of unknown aetiology. (12837347)
2003
27
Prefabricated superficial temporal fascia flap combined with a submental flap in noma surgery. (11884812)
2002
28
Noma in a Nigerian adult. (12139171)
2002
29
Is noma neonatorum a presentation of ecthyma gangrenosum in the newborn? (11791113)
2002
30
International Association for Dental Research. Symposium on Noma. Nice, June 1998. (10522211)
1999
31
The World Health Organization initiative on noma. (10522217)
1999
32
Isolation of Fusobacterium necrophorum from cancrum oris (noma). (9988340)
1999
33
Noma (cancrum oris): questions and answers. (10522212)
1999
34
Noma: public health problem in Senegal and epidemilogical surveillance. (10522215)
1999
35
Cancrum oris (noma) in a patient with acute lymphoblastic leukaemia. A complication of chemotherapy induced neutropenia. (9619095)
1998
36
Fiberoptically guided intubation in children with gangrenous stomatitis (noma). (2382859)
1990
37
Noma in children with severe combined immunodeficiency. (3020218)
1986
38
Noma: report of three adult cases. (6586177)
1983
39
Herpetic primo-infection and noma-like ulceration in tropical Africa. (6307897)
1983
40
Noma in a nonhuman primate. (6944671)
1981
41
Noma neonatorum: Its aetiopathogenesis. (79084)
1978
42
Phospho- and glycosphingolipid metabolism in a rat neuri-noma clone (RN6) studied in tissue culture. (945936)
1976
43
Surgical repair of defects from noma (cancrum oris). (4586230)
1973
44
Epidemiological and biochemical studies of necrotizing ulcerative gingivitis and noma (cancrum oris) in Nigerian children. (4627235)
1972
45
Use of an anticholinergic drug in the closure of an orofacial fistula due to noma. Report of a case. (4381773)
1967
46
NOMA: ITS ASSOCIATION WITH NUTRITIONAL DEPRIVATION AND PHYSICAL DEBILITATION. REPORT OF A CASE. (14176600)
1964
47
Effect of cortisone and somatotrophic hormone upon the development of a noma-like condition in the rat. (13055242)
1953
48
Two cases of noma sequelae treated with scalp flaps. (13003564)
1952
49
A review of noma; report of a case treated with aureomycin. (14863869)
1951
50
Case report; noma. (20292529)
1947

Variations for Noma

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Expression for genes affiliated with Noma

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Search GEO for disease gene expression data for Noma.

Pathways for genes affiliated with Noma

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Pathways related to Noma according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8PTPN11, CDC42
29.8PTPN11, CDC42
3
Show member pathways
Vitamin B12 Metabolism36
9.8APOA1, MPO
49.7APOB, APOA1
5
Show member pathways
9.7APOB, APOA1
6
Show member pathways
9.7APOA1, APOB
79.7CDC42, ARHGAP1
89.7ARHGAP1, CDC42
99.6ALB, APOA1
10
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.6CDC42, NGFR, PTPN11
11
Show member pathways
9.6NGFR, PTPN11, CDC42
129.6CDC42, PTPN11, NGFR
139.5MPO, APOB, AGER
14
Show member pathways
9.4ARHGAP1, CDC42, NGFR
15
Show member pathways
9.2APOB, APOA1, ALB
16
Show member pathways
9.2APOB, ALB, APOA1
17
Show member pathways
thioredoxin pathway36
8.9ALB, MPO, APOB, APOA1
18
Show member pathways
8.8ARHGAP1, CDC42, ARHGAP33
19
Show member pathways
8.6APOB, PTPN11, APOA1, ALB, CDC42
20
Show member pathways
7.4APOA1, ARHGAP1, CDC42, NGFR, PTPN11, APOB

Compounds for genes affiliated with Noma

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Compounds related to Noma according to GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1taxifolin4310.2APOB, MPO
2mechlorethamine4310.1MPO, APOA1
3n(epsilon)-(carboxymethyl)lysine4310.1ALB, AGER
4maxepa4310.1APOB, APOA1
5polyethylene glycol 60004310.1APOA1, APOB
6lynestrenol4310.1APOB, APOA1
7colestipol4310.1APOA1, APOB
8tolmetin43 1211.1MPO, ALB
9aopp4310.0ALB, MPO
10campesterol43 2411.0APOB, APOA1
11chloramine t4310.0APOA1, MPO
12iohexol439.9ALB, APOA1
13pentosidine439.9ALB, AGER
14fenofibric acid43 2810.9APOA1, APOB
15desogestrel43 1210.9APOA1, APOB
16ampicillin43 1210.8MPO, ALB
17metformin43 49 1211.8APOB, APOA1, AGER
18gestodene43 1210.8APOA1, APOB
19lovastatin43 49 59 28 1213.7APOA1, APOB, CDC42
20ciprofibrate43 2810.7APOA1, APOB
21retinyl palmitate43 2410.7APOA1, APOB
22polyethylene glycol439.7MPO, APOA1, ALB
23fructosamine43 2410.7ALB, APOB, APOA1
24rosuvastatin43 49 28 1212.6APOA1, ALB, APOB
25captopril43 59 49 28 1213.6APOA1, ALB, APOB
26superoxide43 2410.6AGER, CDC42, MPO, NGFR
27prednisolone43 28 1211.6ALB, APOB, MPO
28alpha tocopherol439.6APOA1, APOB, ALB
29palmitate439.5APOB, ALB, APOA1
30homocysteine43 2410.5APOA1, APOB, ALB
31indomethacin43 28 59 1212.4NGFR, MPO, APOA1, ALB
32uric acid43 2410.4APOA1, AGER, ALB, APOB
33nadph43 2410.4CDC42, NGFR, PTPN11, MPO, AGER
34dextran sulfate439.4MPO, APOA1, APOB, ALB
35kininogen439.4APOB, MPO, ALB, APOA1
36vitamin b12439.4APOA1, APOB, MPO, ALB
37choline43 24 1211.3APOB, NGFR, APOA1
38acetylcholine43 49 28 24 1213.3NGFR, PTPN11, APOA1, MPO, CDC42
39fibrinogen439.3APOB, APOA1, ALB, PTPN11
40lactate439.2ALB, APOB, MPO, APOA1
41glutamate439.2APOA1, CDC42, APOB, NGFR, PTPN11
42heparin43 28 24 1212.1APOB, MPO, ALB, AGER
43creatinine439.1APOA1, ALB, MPO, APOB, AGER
44vegf439.0NGFR, AGER, MPO, CDC42, APOB, PTPN11
45alanine439.0ALB, PTPN11, CDC42, APOB, APOA1
46thyroxine43 249.9APOA1, ALB, APOB
47cholesterol43 28 24 1211.8ALB, APOB, NGFR, CDC42, AGER, APOA1
48serine438.6NGFR, CDC42, APOA1, AGER, MPO, APOB
49glucose438.5APOA1, APOB, NGFR, AGER, ALB, CDC42
50lipid438.5CDC42, APOB, AGER, ALB, APOA1, PTPN11

GO Terms for genes affiliated with Noma

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Cellular components related to Noma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:00716829.8APOA1, APOB
2very-low-density lipoprotein particleGO:00343619.6APOA1, APOB
3extracellular vesicular exosomeGO:00700628.5CDC42, ALB, MPO, APOA1, ARHGAP1
4extracellular regionGO:00055768.4ALB, AGER, APOB, APOA1, NGFR
5cytosolGO:00058297.5CDC42, NGFR, PTPN11, APOA1, APOB, ARHGAP33
6plasma membraneGO:00058867.5APOB, APOA1, NGFR, CDC42, AGER, ARHGAP1

Biological processes related to Noma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particle remodelingGO:00343749.9MPO, APOB
2lipoprotein biosynthetic processGO:00421589.9APOB, APOA1
3hair follicle morphogenesisGO:00310699.8NGFR, CDC42
4cholesterol transportGO:00303019.8APOB, APOA1
5cholesterol effluxGO:00333449.7APOB, APOA1
6lipoprotein metabolic processGO:00421579.4APOA1, APOB, ALB
7tRNA processingGO:00080339.0TRMT12, TYW3
8regulation of small GTPase mediated signal transductionGO:00510568.9CDC42, ARHGAP1, ARHGAP33
9small GTPase mediated signal transductionGO:00072648.8ARHGAP33, ARHGAP1, CDC42
10blood coagulationGO:00075968.8CDC42, ALB, APOB, APOA1, PTPN11

Molecular functions related to Noma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apolipoprotein A-I receptor bindingGO:00341919.8APOA1, CDC42
2cholesterol transporter activityGO:00171279.4APOB, APOA1
3Rac GTPase activator activityGO:00306759.1ARHGAP33, ARHGAP1
4protein bindingGO:00055156.6NGFR, PTPN11, APOA1, APOB, ALB, CDC42

Products for genes affiliated with Noma

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Sources for Noma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet