NOMA
MCID: NM001
MIFTS: 53

Noma (NOMA) malady

Rare diseases, Infectious diseases, Oral diseases categories
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Summaries for Noma

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MalaCards based summary: Noma, also known as cancrum oris, is related to cerebrovascular disease and leukostasis. An important gene associated with Noma is NGFR (nerve growth factor receptor), and among its related pathways are Netrin-1 signaling and Cell adhesion Cadherin mediated cell adhesion. The compounds taxifolin and mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Noma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 62UMLS, 39NCIt, 57SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Noma, Aliases & Descriptions:

Name: Noma 8 42 48 62
Cancrum Oris 8 42 48 62
Oro-Facial Gangrene 42 62
Stomatitis, Gangrenous 62
 
Gangrenous Stomatitis 8
Noma Neonatorum 42
Oro-Facial Noma 42
Oral Gangrene 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Oral diseases


Characteristics (Orphanet epidemiological data):

48
cancrum oris:
Age of onset: Childhood


External Ids:

Disease Ontology8 DOID:9672
NCIt39 C34852
ICD9CM27 528.1
MeSH34 D009625
MESH via Orphanet35 D009625
ICD10 via Orphanet26 A69.0
UMLS via Orphanet63 C0028271

Related Diseases for Noma

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Diseases related to Noma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1cerebrovascular disease29.9APOB, APOA1
2leukostasis10.4MPO
3hydrops fetalis10.4PTPN11
4stomatitis10.3
5diabetic neuropathy10.3NGFR, AGER
6chylomicron retention disease10.3APOB
7rhinitis10.3ALB
8ankylosis10.3
9necrotizing fasciitis10.3
10fasciitis10.3
11gingivitis10.3
12peripheral vascular disease10.2MPO, ALB
13pdgfrb-associated chronic eosinophilic leukemia10.2MPO, PTPN11
14neurofibromatosis10.2PTPN11, NGFR
15neutropenia10.1
16acquired immunodeficiency syndrome10.1
17alcoholic hepatitis10.1ALB, APOA1
18skin disease10.1ALB, MPO
19leukopenia10.0ALB, MPO
20arcus senilis10.0APOA1, APOB
21acatalasia10.0
22norum disease10.0APOB, APOA1
23familial hypertriglyceridemia10.0APOA1, APOB
24hypobetalipoproteinemia10.0APOA1, APOB
25hyperlipidemia type 310.0APOA1, APOB
26hyperalphalipoproteinemia10.0APOB, APOA1
27abetalipoproteinemia10.0APOA1, APOB
28coronary stenosis10.0APOA1, APOB
29amyloidosis10.0APOA1, ALB, AGER
30hypersensitivity reaction type ii disease10.0ALB, MPO, PTPN11
31familial hyperlipidemia10.0APOA1, APOB
32hypoalphalipoproteinemia10.0APOB, APOA1
33peritonitis10.0MPO, ALB
34cystic fibrosis10.0NGFR, MPO, ALB
35tangier disease10.0APOB, APOA1
36leukemia10.0
37severe combined immunodeficiency10.0
38kwashiorkor10.0
39necrotizing ulcerative gingivitis10.0
40ecthyma10.0
41appendicitis10.0
42measles10.0
43verrucous carcinoma10.0
44cheilitis10.0
45laryngitis10.0
46myiasis10.0
47acute promyelocytic leukemia10.0
48myeloperoxidase deficiency10.0
49sepsis10.0
50familial hypercholesterolemia10.0APOB, APOA1

Graphical network of the top 20 diseases related to Noma:



Diseases related to noma

Symptoms for Noma

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Drugs & Therapeutics for Noma

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Drug clinical trials:

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Genetic Tests for Noma

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Anatomical Context for Noma

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MalaCards organs/tissues related to Noma:

32
Bone

Animal Models for Noma or affiliated genes

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Publications for Noma

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Articles related to Noma:

(show top 50)    (show all 154)
idTitleAuthorsYear
1
Acute gangrenous gingivitis--early stage noma. (24825288)
2014
2
Noma: a neglected enigma. (25104148)
2013
3
Noma in an immunocompromised patient. (24192747)
2013
4
Noma (cancrum oris): a report of a case in a young AIDS patient with a review of the pathogenesis. (22907664)
2013
5
Gillies fan flap for the reconstruction of an upper lip defect caused by noma: case presentation. (23674921)
2012
6
Noma-like lesion in a patient with acute promyelocytic leukemia. (23049328)
2011
7
A case and review of noma. (21200428)
2010
8
Reconstruction of the maxilla with prefabricated scapular flaps in noma patients. (19483590)
2009
9
An oro-facial disease 'noma (cancrum oris)' in a Japanese monkey (Macaca fuscata): clinical signs, clinicopathological features, and response to treatment. (18822072)
2008
10
Recurrent noma (cancrum oris) in human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV and AIDS): report of a case. (18634964)
2008
11
Missing the forest for the trees in biomedical research: the example of noma. (18385341)
2008
12
The use of the pedicled supraclavicular flap in noma reconstructive surgery. (16816717)
2006
13
Response to Taguchi and Noma on "relationship between directionality and orientation in drawings by young children and adults. (16671630)
2006
14
Noma (cancrum oris). (16829299)
2006
15
What is your interpretation of the lesion? Noma. (16892719)
2006
16
The single and double-folded supraclavicular island flap as a new therapy option in the treatment of large facial defects in noma patients. (15861062)
2005
17
Noma (orofacial gangrene). (16101886)
2005
18
Noma: life cycle of a devastating sore - case report and literature review. (16324228)
2005
19
Temporal relationship between the occurrence of fresh noma and the timing of linear growth retardation in Nigerian children. (15655015)
2005
20
Comments on: "Role of individual ionic current systems in ventricular cells hypothesized by a model study" by Matsuoka S, Sarai N, Kuratomi S, Ono K, and Noma A. Jpn J Physiol 53: 105-123, 2003. (15667675)
2004
21
Free flap transfer for closure and interposition-arthroplasty in noma defects of the lateral face associated with bony ankylosis. (15346015)
2004
22
Noma: a forgotten disease. (12848465)
2003
23
An estimation of the incidence of noma in north-west Nigeria. (12753633)
2003
24
Noma: experiences with a microvascular approach under West African conditions. (12973208)
2003
25
Noma: an "infectious" disease of unknown aetiology. (12837347)
2003
26
Prefabricated superficial temporal fascia flap combined with a submental flap in noma surgery. (11884812)
2002
27
Noma in a Nigerian adult. (12139171)
2002
28
Is noma neonatorum a presentation of ecthyma gangrenosum in the newborn? (11791113)
2002
29
International Association for Dental Research. Symposium on Noma. Nice, June 1998. (10522211)
1999
30
The World Health Organization initiative on noma. (10522217)
1999
31
Isolation of Fusobacterium necrophorum from cancrum oris (noma). (9988340)
1999
32
Noma (cancrum oris): questions and answers. (10522212)
1999
33
Noma: public health problem in Senegal and epidemilogical surveillance. (10522215)
1999
34
Cancrum oris (noma) in a patient with acute lymphoblastic leukaemia. A complication of chemotherapy induced neutropenia. (9619095)
1998
35
Fiberoptically guided intubation in children with gangrenous stomatitis (noma). (2382859)
1990
36
Noma in children with severe combined immunodeficiency. (3020218)
1986
37
Noma: report of three adult cases. (6586177)
1983
38
Herpetic primo-infection and noma-like ulceration in tropical Africa. (6307897)
1983
39
Noma in a nonhuman primate. (6944671)
1981
40
Noma neonatorum: Its aetiopathogenesis. (79084)
1978
41
Phospho- and glycosphingolipid metabolism in a rat neuri-noma clone (RN6) studied in tissue culture. (945936)
1976
42
Surgical repair of defects from noma (cancrum oris). (4586230)
1973
43
Epidemiological and biochemical studies of necrotizing ulcerative gingivitis and noma (cancrum oris) in Nigerian children. (4627235)
1972
44
Use of an anticholinergic drug in the closure of an orofacial fistula due to noma. Report of a case. (4381773)
1967
45
NOMA: ITS ASSOCIATION WITH NUTRITIONAL DEPRIVATION AND PHYSICAL DEBILITATION. REPORT OF A CASE. (14176600)
1964
46
Effect of cortisone and somatotrophic hormone upon the development of a noma-like condition in the rat. (13055242)
1953
47
Two cases of noma sequelae treated with scalp flaps. (13003564)
1952
48
A review of noma; report of a case treated with aureomycin. (14863869)
1951
49
Case report; noma. (20292529)
1947
50
Noma treated with penicillin. (20989840)
1946

Variations for Noma

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Expression for genes affiliated with Noma

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Expression patterns in normal tissues for genes affiliated with Noma

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Pathways for genes affiliated with Noma

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Pathways related to Noma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CDC42, PTPN11
29.8PTPN11, CDC42
3
Show member pathways
Vitamin B12 Metabolism37
9.8MPO, APOA1
4
Show member pathways
9.7APOB, APOA1
5
Show member pathways
9.7APOB, APOA1
69.7APOA1, APOB
79.7ARHGAP1, CDC42
89.7CDC42, ARHGAP1
99.6ALB, APOA1
109.6ALB, APOB
11
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.6CDC42, PTPN11, NGFR
12
Show member pathways
9.6NGFR, PTPN11, CDC42
139.6CDC42, PTPN11, NGFR
149.5AGER, MPO, APOB
15
Show member pathways
9.4ARHGAP1, CDC42, NGFR
16
Show member pathways
9.2ALB, APOB, APOA1
17
Show member pathways
9.2ALB, APOB, APOA1
189.2APOA1, APOB, ALB
19
Show member pathways
thioredoxin pathway37
8.9ALB, MPO, APOB, APOA1
20
Show member pathways
8.8CDC42, ARHGAP1, ARHGAP33
21
Show member pathways
8.6PTPN11, APOA1, APOB, ALB, CDC42
22
Show member pathways
7.4NGFR, PTPN11, APOA1, APOB, CDC42, ARHGAP1

Compounds for genes affiliated with Noma

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Compounds related to Noma according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1taxifolin4410.2MPO, APOB
2mechlorethamine4410.1APOA1, MPO
3n(epsilon)-(carboxymethyl)lysine4410.1AGER, ALB
4maxepa4410.1APOB, APOA1
5polyethylene glycol 60004410.1APOB, APOA1
6lynestrenol4410.1APOB, APOA1
7colestipol4410.1APOB, APOA1
8tolmetin44 1111.1MPO, ALB
9aopp4410.0MPO, ALB
10campesterol44 2411.0APOB, APOA1
11chloramine t4410.0MPO, APOA1
12pentosidine4410.0AGER, ALB
13iohexol449.9ALB, APOA1
14fenofibric acid44 2810.9APOB, APOA1
15desogestrel44 1110.9APOA1, APOB
16ampicillin44 1110.8ALB, MPO
17metformin44 50 1111.8AGER, APOB, APOA1
18gestodene44 1110.8APOA1, APOB
19lovastatin44 50 61 28 1113.7APOA1, APOB, CDC42
20ciprofibrate44 2810.7APOA1, APOB
21retinyl palmitate44 2410.7APOB, APOA1
22polyethylene glycol449.7ALB, MPO, APOA1
23fructosamine44 2410.7APOA1, APOB, ALB
24rosuvastatin44 50 28 1112.6APOA1, APOB, ALB
25captopril44 61 50 28 1113.6APOA1, APOB, ALB
26superoxide44 2410.6NGFR, MPO, CDC42, AGER
27prednisolone44 28 1111.6ALB, MPO, APOB
28alpha tocopherol449.6ALB, APOB, APOA1
29palmitate449.5ALB, APOB, APOA1
30homocysteine44 2410.5APOA1, APOB, ALB
31indomethacin44 28 61 1112.4NGFR, APOA1, MPO, ALB
32uric acid44 2410.4AGER, ALB, APOB, APOA1
33nadph44 2410.4NGFR, PTPN11, MPO, CDC42, AGER
34dextran sulfate449.4ALB, MPO, APOB, APOA1
35kininogen449.4APOA1, APOB, MPO, ALB
36vitamin b12449.4ALB, MPO, APOB, APOA1
37choline44 24 1111.3APOB, APOA1, NGFR
38acetylcholine44 50 28 24 1113.3NGFR, PTPN11, APOA1, MPO, CDC42
39fibrinogen449.3PTPN11, APOA1, APOB, ALB
40lactate449.2APOA1, APOB, MPO, ALB
41glutamate449.2NGFR, PTPN11, APOA1, APOB, CDC42
42heparin44 28 24 1112.1AGER, ALB, MPO, APOB
43creatinine449.1APOA1, APOB, MPO, ALB, AGER
44vegf449.0NGFR, PTPN11, APOB, MPO, CDC42, AGER
45alanine449.0CDC42, ALB, APOB, APOA1, PTPN11
46thyroxine44 249.9APOA1, APOB, ALB
47cholesterol44 28 24 1111.8NGFR, APOA1, APOB, ALB, CDC42, AGER
48serine448.6NGFR, PTPN11, APOA1, APOB, MPO, CDC42
49glucose448.5NGFR, PTPN11, APOA1, APOB, ALB, CDC42
50lipid448.5NGFR, PTPN11, APOA1, APOB, ALB, CDC42

GO Terms for genes affiliated with Noma

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Cellular components related to Noma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:0716829.8APOB, APOA1
2very-low-density lipoprotein particleGO:0343619.6APOB, APOA1
3extracellular vesicular exosomeGO:0700628.5ARHGAP1, CDC42, ALB, MPO, APOA1
4extracellular regionGO:0055768.4NGFR, APOA1, APOB, ALB, AGER
5cytosolGO:0058297.5ARHGAP33, NGFR, PTPN11, APOA1, APOB, CDC42
6plasma membraneGO:0058867.5NGFR, APOA1, APOB, CDC42, AGER, ARHGAP1

Biological processes related to Noma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particle remodelingGO:0343749.9MPO, APOB
2lipoprotein biosynthetic processGO:0421589.9APOB, APOA1
3hair follicle morphogenesisGO:0310699.8NGFR, CDC42
4cholesterol transportGO:0303019.8APOB, APOA1
5cholesterol effluxGO:0333449.7APOB, APOA1
6lipoprotein metabolic processGO:0421579.4APOA1, APOB, ALB
7tRNA processingGO:0080339.0TRMT12, TYW3
8regulation of small GTPase mediated signal transductionGO:0510568.9CDC42, ARHGAP1, ARHGAP33
9small GTPase mediated signal transductionGO:0072648.8ARHGAP33, ARHGAP1, CDC42
10blood coagulationGO:0075968.8CDC42, ALB, APOB, APOA1, PTPN11

Molecular functions related to Noma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apolipoprotein A-I receptor bindingGO:0341919.8CDC42, APOA1
2cholesterol transporter activityGO:0171279.4APOB, APOA1
3Rac GTPase activator activityGO:0306759.1ARHGAP33, ARHGAP1
4protein bindingGO:0055156.6NGFR, PTPN11, APOA1, APOB, ALB, CDC42

Products for genes affiliated with Noma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Noma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet