MCID: NNH002
MIFTS: 27

Non-a-E Hepatitis malady

Summaries for Non-a-E Hepatitis

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Non-a-e hepatitis, sometimes referred to as hepatitis x, is a disease of the liver that is diagnosed when there is swelling of the liver (hepatitis) but examination and testing does not identify a cause.  symptoms of non-a-e hepatitis may include feeling tired or unwell (malaise), nausea, vomiting, pain in the abdomen, and fever.  non-a-e hepatitis usually goes away on its own, but it can become a chronic condition in a small proportion (12%) of affected individuals.  the cause of non-a-e hepatitis is currently unknown. last updated: 8/16/2012

MalaCards: Non-a-E Hepatitis, also known as viral hepatitis non-a,-b,-c,-d,-e, is related to hepatitis a and hepatitis c. An important gene associated with Non-a-E Hepatitis is AMACR (alpha-methylacyl-CoA racemase). The compounds monoethylglycinexylidide and ximelagatran have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and b cells.

Aliases & Classifications for Non-a-E Hepatitis

Sources:
43NIH Rare Diseases
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Aliases & Descriptions:

non-a-e hepatitis 43
viral hepatitis non-a,-b,-c,-d,-e 43
hepatitis x 43


Related Diseases for Non-a-E Hepatitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Non-a-E Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis a31.0F2
2hepatitis c30.9AMACR, SLC17A5, F2, GPT
3hepatitis e30.7GPT
4hepatitis b30.6F2, GPT, SLC17A5
5acute liver failure30.2GPT, SLC17A5, F2
6viral hepatitis30.2SLC17A5, F2, GPT
7hepatitis d10.6
8hepatitis c virus10.5
9aplastic anemia10.1
10biliary tract disease10.1
11hepatitis b virus infection10.1
12cystic fibrosis10.0AMACR
13galactosemia10.0F2
14thromboembolism10.0F2
15cholelithiasis10.0GPT
16tuberculosis10.0AMACR
17biliary atresia10.0GPT
18myelodysplastic syndromes10.0AMACR
19stomach cancer10.0AMACR
20melanoma10.0AMACR
21lipoma10.0AMACR
22peritonitis10.0F2
23cholecystitis10.0GPT
24disseminated intravascular coagulation10.0F2
25cryoglobulinemia10.0SLC17A5
26hyperthyroidism10.0SLC17A5
27prostate cancer10.0AMACR
28glucose intolerance10.0GPT
29pancreatitis10.0SLC17A5
30ischemia10.0SLC17A5
31hellp syndrome10.0SLC17A5, GPT
32pyridoxine deficiency10.0SLC17A5, GPT
33wilson disease10.0GPT, SLC17A5
34cholangitis10.0GPT, SLC17A5
35obstructive jaundice10.0GPT, SLC17A5
36acute pancreatitis10.0SLC17A5, GPT
37hypercholesterolemia10.0GPT, SLC17A5
38choledocholithiasis10.0SLC17A5, GPT
39scrub typhus10.0GPT, SLC17A5
40congenital generalized lipodystrophy type 310.0SLC17A5, GPT
41splenomegaly10.0GPT, SLC17A5
42alcohol abuse10.0GPT, SLC17A5
43familial hyperlipidemia10.0SLC17A5, GPT
44fatty liver disease10.0SLC17A5, GPT
45factor v leiden thrombophilia10.0AMACR, SLC17A5, F2
46portal hypertension10.0SLC17A5, F2, GPT
47bilirubin metabolic disorder10.0F2, GPT, SLC17A5
48alcoholic hepatitis10.0SLC17A5, F2, GPT
49cholestasis10.0F2, SLC17A5, GPT
50alcoholic liver cirrhosis10.0SLC17A5, F2, GPT

Graphical network of the top 20 diseases related to Non-a-E Hepatitis:



Diseases related to non-a-e hepatitis

Clinical Features for Non-a-E Hepatitis

Drugs & Therapeutics for Non-a-E Hepatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Non-a-E Hepatitis

Drug clinical trials:

Search ClinicalTrials for Non-a-E Hepatitis

Search NIH Clinical Center for Non-a-E Hepatitis

Search CenterWatch for Non-a-E Hepatitis

Genetic Tests for Non-a-E Hepatitis

Anatomical Context for Non-a-E Hepatitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Non-a-E Hepatitis:

33
Liver, T cells, B cells

Animal Models for Non-a-E Hepatitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Non-a-E Hepatitis

Sources:
51PubMed
See all sources

Articles related to Non-a-E Hepatitis:

(show all 22)
idTitleAuthorsYear
1
Recombinant Nonstructural 3 Protein, rNS3, of Hepatitis C Virus Along With Recombinant GP96 Induce IL-12, TNFI+ and I+5integrin Expression in Antigen Presenting Cells. (24032046)
2013
2
Alphavirus-based vaccines encoding nonstructural proteins of Hepatitis C virus induce robust and protective T cell responses. (24370701)
2013
3
Explaining differences in hepatitis C between U.S. veterans and nonveterans in treatment for substance abuse: results from a regression decomposition. (23869458)
2013
4
Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication. (23248316)
2013
5
Noninvasive diagnostic criteria for hepatocellular carcinoma in hepatic masses >2 cm in a hepatitis B virus-endemic area. (21745284)
2011
6
Relative etiological role of prior hepatitis B virus infection and nonalcoholic fatty liver disease in the development of non-B non-C hepatocellular carcinoma in a hepatitis B-endemic area. (22156481)
2011
7
Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1. (20971080)
2010
8
Evaluation of quantitative portal venous, hepatic arterial, and total hepatic tissue blood flow using xenon CT in alcoholic liver cirrhosis-comparison with liver cirrhosis related to hepatitis C virus and nonalcoholic steatohepatitis. (18986379)
2010
9
Measurement of liver elasticity with acoustic radiation force impulse (ARFI) technology: an alternative noninvasive method for staging liver fibrosis in viral hepatitis. (20306380)
2010
10
Liver fibrosis in viral hepatitis: noninvasive assessment with acoustic radiation force impulse imaging versus transient elastography. (19703889)
2009
11
Elevated serum levels of caspase-cleaved cytokeratin 18 (CK18-Asp396) in patients with nonalcoholic steatohepatitis and chronic hepatitis C. (19333204)
2009
12
Incidence of psychiatric side effects during pegylated interferon- alpha retreatment in nonresponder hepatitis C virus-infected patients. (17845538)
2007
13
Changes in gene expression during pegylated interferon and ribavirin therapy of chronic hepatitis C virus distinguish responders from nonresponders to antiviral therapy. (17267482)
2007
14
DNA immunization efficiently targets conserved functional domains of protease and ATPase/helicase of nonstructural 3 protein (NS3) of human hepatitis C virus. (12853154)
2003
15
Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein. (12743294)
2003
16
Early prediction of nonresponders to treatment with interferon alpha-2b and ribavirin in patients with chronic hepatitis C. (12945009)
2003
17
Effects of mutation in hepatitis C virus nonstructural protein 5A on interferon resistance mediated by inhibition of PKR kinase activity in mammalian cells. (11838900)
2001
18
Effect of the dose and duration of interferon-alpha therapy on the incidence of hepatocellular carcinoma in noncirrhotic patients with a nonsustained response to interferon for chronic hepatitis C. (11528252)
2001
19
Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo. (10644379)
2000
20
Comparative efficacy of interferon alfa in cirrhotic and noncirrhotic patients with non-A, non-B, C hepatitis. Le Groupe FranAsais pour l'Etude du Traitement des HAcpatites Chroniques NANB/C. (7907073)
1994
21
Antibody response to core, envelope and nonstructural hepatitis C virus antigens: comparison of immunocompetent and immunosuppressed patients. (7689528)
1993
22
Hepatocyte regeneration in acute fulminant and nonfulminant hepatitis: a study of proliferating cell nuclear antigen expression. (1372584)
1992

Genetic Variations for Non-a-E Hepatitis

Expression for genes affiliated with Non-a-E Hepatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Non-a-E Hepatitis

Search GEO for disease gene expression data for Non-a-E Hepatitis.

Pathways for genes affiliated with Non-a-E Hepatitis

Compounds for genes affiliated with Non-a-E Hepatitis

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Non-a-E Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1monoethylglycinexylidide459.8GPT, F2
2ximelagatran45 1110.8F2, GPT
3clarithromycin45 1110.7GPT, F2
4lamivudine45 1110.6SLC17A5, F2
5antipyrine45 1110.5SLC17A5, F2
6levonorgestrel45 60 29 1112.5SLC17A5, F2
7amiodarone45 50 29 1112.5F2, SLC17A5
85-hydroxytryptophol459.5GPT, SLC17A5
9alpha-hydroxybutyrate459.5SLC17A5, GPT
10d-galactosamine459.5SLC17A5, GPT
11lactulose459.4GPT, SLC17A5
12adefovir459.4GPT, SLC17A5
13glycocholate459.4GPT, SLC17A5
14tenofovir45 50 1111.4GPT, SLC17A5
15glycyrrhizin45 2910.4GPT, SLC17A5
16nash459.4SLC17A5, GPT
17lidocaine45 29 1111.4SLC17A5, F2
18nevirapine45 50 1111.4SLC17A5, GPT
19sevoflurane45 1110.4SLC17A5, GPT
20isoniazid50 45 1111.4SLC17A5, GPT
21digoxin45 50 60 11 2413.4F2, SLC17A5
22isoflurane45 1110.4SLC17A5, GPT
23ezetimibe45 1110.4SLC17A5, GPT
24flutamide45 60 1111.3SLC17A5, GPT
25rosuvastatin45 50 29 1112.3SLC17A5, GPT
26disulfiram45 60 1111.3GPT, SLC17A5
27bezafibrate45 29 1111.3GPT, SLC17A5
28phosphorus459.2SLC17A5, GPT
29risperidone29 45 50 60 11 2414.2GPT, SLC17A5
30valproate459.1GPT, SLC17A5
31pyridoxal 5-phosphate459.0SLC17A5, GPT
32rifampicin45 29 6011.0SLC17A5, GPT
33hepaplastin459.0F2, GPT, SLC17A5
34aminopyrine459.0F2, GPT, SLC17A5
35ursodeoxycholic acid45 11 2411.0F2, SLC17A5, GPT
36silymarin459.0F2, GPT, SLC17A5
37acetaminophen45 2 50 11 2412.9SLC17A5, F2, GPT
38pge1458.9GPT, F2, SLC17A5
39fenofibrate45 50 1110.9GPT, SLC17A5
40simvastatin45 50 60 29 11 2413.9F2, SLC17A5, GPT
41hyaluronic acid45 249.9GPT, SLC17A5, F2
42chloride458.9AMACR, SLC17A5, GPT
43methotrexate45 50 1110.9GPT, SLC17A5, F2
44n acetylcysteine458.9SLC17A5, F2, GPT
45fibrinogen458.9GPT, SLC17A5, F2
46cyclosporin a45 29 6010.8GPT, F2, SLC17A5
47lactate458.8GPT, F2, SLC17A5
48ribavirin45 50 1110.7GPT, SLC17A5
49creatinine458.7GPT, F2, SLC17A5
50aspartate458.6GPT, F2, SLC17A5

GO Terms for genes affiliated with Non-a-E Hepatitis

Products for genes affiliated with Non-a-E Hepatitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Non-a-E Hepatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet