MCID: NNF001
MIFTS: 32

Non-Functioning Pancreatic Endocrine Tumor

Categories: Rare diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Non-Functioning Pancreatic Endocrine Tumor

MalaCards integrated aliases for Non-Functioning Pancreatic Endocrine Tumor:

Name: Non-Functioning Pancreatic Endocrine Tumor 12 14
Non Functioning Pancreatic Endocrine Tumor 50 42 69
Non-Functioning Endocrine Pancreatic Tumors 50
Non-Functioning Epts 50

Classifications:



External Ids:

Disease Ontology 12 DOID:7698
MeSH 42 C536126
NCIt 47 C45837
UMLS 69 C1334977

Summaries for Non-Functioning Pancreatic Endocrine Tumor

MalaCards based summary : Non-Functioning Pancreatic Endocrine Tumor, also known as non functioning pancreatic endocrine tumor, is related to persistent hyperplastic primary vitreous, autosomal recessive and malignant ovarian mixed epithelial neoplasm. An important gene associated with Non-Functioning Pancreatic Endocrine Tumor is SOX17 (SRY-Box 17), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Regulation of beta-cell development. The drugs Pancrelipase and pancreatin have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and cellular

Related Diseases for Non-Functioning Pancreatic Endocrine Tumor

Diseases related to Non-Functioning Pancreatic Endocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Related Disease Score Top Affiliating Genes
1 persistent hyperplastic primary vitreous, autosomal recessive 10.8 CHGA NEUROG3
2 malignant ovarian mixed epithelial neoplasm 10.7 CHGA SYP
3 ampulla of vater small cell carcinoma 10.7 CHGA SYP
4 spinal cord ependymoma 10.7 CHGA SYP
5 ludwig's angina 10.7 CHGA SYP
6 signet ring cell intrahepatic cholangiocarcinoma 10.7 CHGA SYP
7 childhood choriocarcinoma of the ovary 10.7 CHGA SYP
8 osteoblastoma 10.7 CHGA SYP
9 esophagus adenocarcinoma 10.7 CHGA SYP
10 basophilic carcinoma 10.7 CHGA SYP
11 cystitis cystica 10.7 CHGA SYP
12 small intestine cancer, childhood 10.7 CHGA SYP
13 neurogenic thoracic outlet syndrome 10.7 CHGA SYP
14 aicardi-goutieres syndrome 10.7 CHGA SYP
15 macular retinal edema 10.7 POU5F1 SOX2
16 diffuse infiltrative lymphocytosis syndrome 10.7 CHGA SYP
17 visual cortex disease 10.7 POU5F1 SOX2
18 congenital granular cell tumor 10.7 CHGA SYP
19 reticular pattern testicular yolk sac tumor 10.7 CHGA SYP
20 mast cell neoplasm 10.6 CHGA SYP
21 diffuse lipomatosis 10.6 CHGA SYP
22 pleomorphic xanthoastrocytoma 10.6 CHGA SYP
23 thyroid sarcoma 10.6 CHGA SYP
24 sudden sensorineural hearing loss 10.6 CHGA SYP
25 central nervous system hematologic cancer 10.6 CHGA SYP
26 pituitary dwarfism with large sella turcica 10.6 CHGA SYP
27 pneumonia 10.6 CHGA SYP
28 ethmoid sinus schneiderian papilloma 10.6 CHGA SYP
29 rete ovarii cystadenofibroma 10.6 CHGA SYP
30 pancreatic agenesis 10.6 CHGA SYP
31 nose disease 10.6 CHGA SYP
32 congenital mesoblastic nephroma 10.6 CHGA SYP
33 cowden syndrome 3 10.6 CHGA SYP
34 autoimmune enteropathy 10.6 CHGA GAST
35 hepatorenal syndrome 10.6 CHGA SYP
36 primary syphilis 10.6 CHGA GAST
37 bone giant cell sarcoma 10.6 CHGA GAST
38 tricuspid valve insufficiency 10.6 CHGA SYP
39 brain stem ependymoma 10.6 CHGA SYP
40 pediatric ependymoma 10.6 CHGA SYP
41 gliofibroma 10.5 CHGA SYP
42 group b strep disease in newborns 10.5 CHGA SYP
43 gorlin bushkell jensen syndrome 10.5 CHGA GAST
44 human t-cell leukemia virus type 1 10.5 CHGA SYP
45 central nervous system melanocytic neoplasm 10.5 CHGA SYP
46 calcific tendinitis 10.5 CHGA SYP
47 pneumothorax 10.5 POU5F1 SYP
48 bladder cancer, childhood 10.5 CHGA SYP
49 gastric gastrinoma 10.5 CHGA GAST
50 carcinoma of unknown primary site, childhood 10.5 CHGA SYP

Graphical network of the top 20 diseases related to Non-Functioning Pancreatic Endocrine Tumor:



Diseases related to Non-Functioning Pancreatic Endocrine Tumor

Symptoms & Phenotypes for Non-Functioning Pancreatic Endocrine Tumor

MGI Mouse Phenotypes related to Non-Functioning Pancreatic Endocrine Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 POU5F1 PPY PTF1A SOX2 SYP TOP2B
2 cellular MP:0005384 9.97 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
3 digestive/alimentary MP:0005381 9.86 FOXA2 GAST GHRL NEUROG3 POU5F1 PTF1A
4 endocrine/exocrine gland MP:0005379 9.85 CHGA FOXA2 GAST GHRL NEUROG3 NKX6-1
5 mortality/aging MP:0010768 9.7 CHGA FOXA2 GAST NEUROG3 NKX6-1 NKX6-2
6 normal MP:0002873 9.32 POU5F1 PTF1A SOX17 SOX2 SYP TOP2B

Drugs & Therapeutics for Non-Functioning Pancreatic Endocrine Tumor

Drugs for Non-Functioning Pancreatic Endocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved Phase 4 53608-75-6
2 pancreatin Phase 4
3 Fluorodeoxyglucose F18 Phase 4
4 lanreotide Approved Phase 3 108736-35-2
5
Somatostatin Approved Phase 3 38916-34-6, 51110-01-1 53481605
6 Hormone Antagonists Phase 3
7 Hormones Phase 3
8 Angiopeptin Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
10 Pharmaceutical Solutions Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Nonfunctional Pancreatic NET and PET Imaging Recruiting NCT02621541 Phase 4
2 Clinical Effectiveness of Serum Chromogranin A Levels on Diagnostic of Pancreatic Neuroendocrine Tumors Active, not recruiting NCT02759718 Phase 4
3 Study of Lanreotide Autogel 120 mg in Patients With Non-functioning Entero- Pancreatic Endocrine Tumour Completed NCT00842348 Phase 3 lanreotide (Autogel formulation)
4 Study of Lanreotide Autogel in Non-functioning Entero-pancreatic Endocrine Tumours Completed NCT00353496 Phase 3 lanreotide (Autogel formulation);Placebo
5 Non-functioning Pancreatic Neuroendocrine Tumors in MEN1: Somatostatin Analogs Versus NO Treatment Not yet recruiting NCT02705651 Phase 3 Somatostatin-Analog
6 Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor Withdrawn NCT02831179 Phase 1 Capecitabine;Temozolomide;Veliparib
7 An Analysis of Presentation and Outcome Following Treatment of Pancreatic Endocrine Neoplasms Completed NCT02400996
8 Asymptomatic Small Pancreatic Endocrine Neoplasms. Recruiting NCT03084770
9 Nonfunctioning Small (≤2 cm) Neuroendocrine Pancreatic Incidentaloma Not yet recruiting NCT03022188

Search NIH Clinical Center for Non-Functioning Pancreatic Endocrine Tumor

Cochrane evidence based reviews: non functioning pancreatic endocrine tumor

Genetic Tests for Non-Functioning Pancreatic Endocrine Tumor

Anatomical Context for Non-Functioning Pancreatic Endocrine Tumor

Publications for Non-Functioning Pancreatic Endocrine Tumor

Articles related to Non-Functioning Pancreatic Endocrine Tumor:

id Title Authors Year
1
Non-functioning pancreatic endocrine tumors: eleven-year experience in a single institute. ( 24965405 )
2014

Variations for Non-Functioning Pancreatic Endocrine Tumor

Expression for Non-Functioning Pancreatic Endocrine Tumor

Search GEO for disease gene expression data for Non-Functioning Pancreatic Endocrine Tumor.

Pathways for Non-Functioning Pancreatic Endocrine Tumor

GO Terms for Non-Functioning Pancreatic Endocrine Tumor

Cellular components related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 PTF1A SOX17 SOX2

Biological processes related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 transcription from RNA polymerase II promoter GO:0006366 9.91 NEUROG3 NKX6-1 POU5F1 PTF1A SOX2
2 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.88 NEUROG3 NKX6-1 NKX6-2 POU5F1 SOX17 SOX2
3 multicellular organism development GO:0007275 9.87 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
4 forebrain development GO:0030900 9.67 NEUROG3 SOX2 TOP2B
5 positive regulation of cell differentiation GO:0045597 9.61 NEUROG3 SOX17 SOX2
6 oligodendrocyte differentiation GO:0048709 9.57 NKX6-1 NKX6-2
7 pancreas development GO:0031016 9.56 NKX6-1 PTF1A
8 hindbrain development GO:0030902 9.55 NEUROG3 PTF1A
9 mRNA transcription from RNA polymerase II promoter GO:0042789 9.54 POU5F1 SOX17
10 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.5 FOXA2 NEUROG3 NKX6-1 POU5F1 PTF1A SOX17
11 endodermal cell fate specification GO:0001714 9.48 POU5F1 SOX2
12 positive regulation of glial cell differentiation GO:0045687 9.46 NKX6-1 NKX6-2
13 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification GO:0021913 9.37 NKX6-1 NKX6-2
14 negative regulation of glial cell differentiation GO:0045686 9.26 NKX6-1 NKX6-2
15 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification GO:0021912 9.16 NKX6-1 NKX6-2
16 endocrine pancreas development GO:0031018 8.92 FOXA2 NEUROG3 NKX6-1 NKX6-2
17 regulation of transcription, DNA-templated GO:0006355 10.13 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A

Molecular functions related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor activity, sequence-specific DNA binding GO:0003700 9.7 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 SOX17
2 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.62 FOXA2 NEUROG3 NKX6-1 NKX6-2
3 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.61 FOXA2 POU5F1 SOX17
4 DNA binding GO:0003677 9.61 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
5 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 9.54 NEUROG3 NKX6-1 NKX6-2
6 hormone activity GO:0005179 9.43 GAST GHRL PPY
7 miRNA binding GO:0035198 9.4 POU5F1 SOX2
8 sequence-specific DNA binding GO:0043565 9.17 FOXA2 NKX6-1 NKX6-2 POU5F1 PTF1A SOX17

Sources for Non-Functioning Pancreatic Endocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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