MCID: NNF001
MIFTS: 35

Non-Functioning Pancreatic Endocrine Tumor

Categories: Rare diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Non-Functioning Pancreatic Endocrine Tumor

MalaCards integrated aliases for Non-Functioning Pancreatic Endocrine Tumor:

Name: Non-Functioning Pancreatic Endocrine Tumor 12 14
Non Functioning Pancreatic Endocrine Tumor 49 41 69
Non-Functioning Endocrine Pancreatic Tumors 49
Non-Functioning Epts 49

Classifications:



External Ids:

Disease Ontology 12 DOID:7698
MeSH 41 C536126
NCIt 46 C45837
UMLS 69 C1334977

Summaries for Non-Functioning Pancreatic Endocrine Tumor

MalaCards based summary : Non-Functioning Pancreatic Endocrine Tumor, also known as non functioning pancreatic endocrine tumor, is related to diarrhea 4, malabsorptive, congenital and ureter small cell carcinoma. An important gene associated with Non-Functioning Pancreatic Endocrine Tumor is SOX17 (SRY-Box 17), and among its related pathways/superpathways are Developmental Biology and Mesodermal Commitment Pathway. The drugs Pancrelipase and Fluorodeoxyglucose F18 have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and cellular

Related Diseases for Non-Functioning Pancreatic Endocrine Tumor

Diseases related to Non-Functioning Pancreatic Endocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 diarrhea 4, malabsorptive, congenital 10.5 CHGA NEUROG3
2 ureter small cell carcinoma 10.4 CHGA SYP
3 esophageal neuroendocrine tumor 10.4 CHGA SYP
4 urinary bladder small cell neuroendocrine carcinoma 10.4 CHGA SYP
5 ovarian large-cell neuroendocrine carcinoma 10.4 CHGA SYP
6 auditory system cancer 10.4 CHGA SYP
7 adenoma of the pancreas 10.4 CHGA SYP
8 acinar cell cystadenocarcinoma 10.4 CHGA SYP
9 peritoneal serous adenocarcinoma 10.4 CHGA SYP
10 cellular ependymoma 10.4 CHGA SYP
11 gallbladder small cell carcinoma 10.4 CHGA SYP
12 primary hepatic neuroendocrine carcinoma 10.4 CHGA SYP
13 small cell carcinoma of the bladder 10.4 CHGA SYP
14 gastrointestinal neuroendocrine tumor 10.4 CHGA SYP
15 pulmonary large cell neuroendocrine carcinoma 10.4 CHGA SYP
16 atypical follicular adenoma 10.4 CHGA SYP
17 central nervous system germ cell tumor 10.4 POU5F1 SOX2
18 chordoid meningioma 10.4 CHGA SYP
19 ovarian embryonal carcinoma 10.4 POU5F1 SOX2
20 olfactory nerve neoplasm 10.4 CHGA SYP
21 pancreatic serous cystadenoma 10.4 CHGA SYP
22 cauda equina neoplasm 10.4 CHGA SYP
23 conventional angiosarcoma 10.4 CHGA SYP
24 autoimmune atrophic gastritis 10.4 CHGA GAST
25 subependymoma 10.4 CHGA SYP
26 gastrointestinal neuroendocrine benign tumor 10.4 CHGA GAST
27 gastric neuroendocrine neoplasm 10.4 CHGA GAST
28 pulmonary sclerosing hemangioma 10.4 CHGA SYP
29 pineocytoma 10.4 CHGA SYP
30 gastric squamous cell carcinoma 10.4 CHGA SYP
31 gastric small cell carcinoma 10.4 CHGA SYP
32 pancreatoblastoma 10.4 CHGA SYP
33 small cell neuroendocrine carcinoma 10.4 CHGA SYP
34 pulmonary blastoma 10.4 CHGA SYP
35 pleomorphic xanthoastrocytoma 10.3 CHGA SYP
36 goblet cell carcinoid 10.3 CHGA GAST
37 carcinoid tumors, intestinal 10.3 CHGA SYP
38 ureter, cancer of 10.3 CHGA SYP
39 tanycytic ependymoma 10.3 CHGA SYP
40 hyperinsulinemic hypoglycemia, familial, 2 10.3 CHGA GAST
41 papillary ependymoma 10.3 CHGA SYP
42 cranial nerve malignant neoplasm 10.3 CHGA SYP
43 malignant teratoma 10.3 POU5F1 SYP
44 vipoma 10.3 CHGA GAST
45 sclerosing hemangioma 10.3 CHGA SYP
46 central neurocytoma 10.3 CHGA SYP
47 pancreatic cystadenocarcinoma 10.3 CHGA SYP
48 binswanger's disease 10.3 CHGA SYP
49 carcinoid syndrome 10.3 CHGA SYP
50 pineoblastoma 10.3 POU5F1 SYP

Graphical network of the top 20 diseases related to Non-Functioning Pancreatic Endocrine Tumor:



Diseases related to Non-Functioning Pancreatic Endocrine Tumor

Symptoms & Phenotypes for Non-Functioning Pancreatic Endocrine Tumor

MGI Mouse Phenotypes related to Non-Functioning Pancreatic Endocrine Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 FOXA2 GHRL NKX6-1 NKX6-2 POU5F1 PPY
2 cellular MP:0005384 10.02 SOX2 TOP2B PTF1A SOX17 FOXA2 NEUROG3
3 endocrine/exocrine gland MP:0005379 9.96 CHGA FOXA2 GAST GHRL NEUROG3 NKX6-1
4 digestive/alimentary MP:0005381 9.92 SOX17 SOX2 FOXA2 GAST GHRL NEUROG3
5 mortality/aging MP:0010768 9.9 CHGA FOXA2 GAST NEUROG3 NKX6-1 NKX6-2
6 no phenotypic analysis MP:0003012 9.43 NEUROG3 NKX6-1 PTF1A SOX17 SOX2 CHGA
7 normal MP:0002873 9.32 FOXA2 GHRL NEUROG3 NKX6-2 POU5F1 PTF1A

Drugs & Therapeutics for Non-Functioning Pancreatic Endocrine Tumor

Drugs for Non-Functioning Pancreatic Endocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 4 53608-75-6
2 Fluorodeoxyglucose F18 Phase 4
3 pancreatin Phase 4
4
Somatostatin Approved, Investigational Phase 3 38916-34-6, 51110-01-1 53481605
5
Everolimus Approved Phase 3 159351-69-6 6442177
6
Sirolimus Approved, Investigational Phase 3 53123-88-9 46835353 6436030 5284616
7 Hormone Antagonists Phase 3
8 Hormones Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
10 Immunosuppressive Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nonfunctional Pancreatic NET and PET Imaging Recruiting NCT02621541 Phase 4
2 Clinical Effectiveness of Serum Chromogranin A Levels on Diagnostic of Pancreatic Neuroendocrine Tumors Active, not recruiting NCT02759718 Phase 4
3 Non-functioning Pancreatic Neuroendocrine Tumors in MEN1: Somatostatin Analogs Versus NO Treatment Not yet recruiting NCT02705651 Phase 3 Somatostatin-Analog
4 Cabozantinib S-malate in Treating Patients With Neuroendocrine Tumors Previously Treated With Everolimus That Are Locally Advanced, Metastatic, or Cannot Be Removed by Surgery Not yet recruiting NCT03375320 Phase 3 Cabozantinib S-malate
5 Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor Withdrawn NCT02831179 Phase 1 Capecitabine;Temozolomide;Veliparib
6 Asymptomatic Small Pancreatic Endocrine Neoplasms. Recruiting NCT03084770

Search NIH Clinical Center for Non-Functioning Pancreatic Endocrine Tumor

Cochrane evidence based reviews: non functioning pancreatic endocrine tumor

Genetic Tests for Non-Functioning Pancreatic Endocrine Tumor

Anatomical Context for Non-Functioning Pancreatic Endocrine Tumor

Publications for Non-Functioning Pancreatic Endocrine Tumor

Articles related to Non-Functioning Pancreatic Endocrine Tumor:

# Title Authors Year
1
Non-functioning pancreatic endocrine tumors: eleven-year experience in a single institute. ( 24965405 )
2014

Variations for Non-Functioning Pancreatic Endocrine Tumor

Expression for Non-Functioning Pancreatic Endocrine Tumor

Search GEO for disease gene expression data for Non-Functioning Pancreatic Endocrine Tumor.

Pathways for Non-Functioning Pancreatic Endocrine Tumor

GO Terms for Non-Functioning Pancreatic Endocrine Tumor

Cellular components related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 PTF1A SOX17 SOX2

Biological processes related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.91 NEUROG3 NKX6-1 POU5F1 PTF1A SOX2
2 multicellular organism development GO:0007275 9.87 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.85 NEUROG3 NKX6-1 NKX6-2 POU5F1 SOX17 SOX2
4 forebrain development GO:0030900 9.67 NEUROG3 SOX2 TOP2B
5 positive regulation of cell differentiation GO:0045597 9.61 NEUROG3 SOX17 SOX2
6 oligodendrocyte differentiation GO:0048709 9.57 NKX6-1 NKX6-2
7 pancreas development GO:0031016 9.56 NKX6-1 PTF1A
8 hindbrain development GO:0030902 9.55 NEUROG3 PTF1A
9 mRNA transcription by RNA polymerase II GO:0042789 9.54 POU5F1 SOX17
10 positive regulation of transcription by RNA polymerase II GO:0045944 9.5 FOXA2 NEUROG3 NKX6-1 POU5F1 PTF1A SOX17
11 endodermal cell fate specification GO:0001714 9.48 POU5F1 SOX2
12 positive regulation of glial cell differentiation GO:0045687 9.46 NKX6-1 NKX6-2
13 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification GO:0021913 9.4 NKX6-1 NKX6-2
14 negative regulation of glial cell differentiation GO:0045686 9.26 NKX6-1 NKX6-2
15 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification GO:0021912 9.16 NKX6-1 NKX6-2
16 endocrine pancreas development GO:0031018 8.92 FOXA2 NEUROG3 NKX6-1 NKX6-2
17 regulation of transcription, DNA-templated GO:0006355 10.13 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A

Molecular functions related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.81 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.62 FOXA2 NEUROG3 NKX6-1 NKX6-2
3 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.61 FOXA2 POU5F1 SOX17
4 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001078 9.54 NEUROG3 NKX6-1 NKX6-2
5 DNA binding transcription factor activity GO:0003700 9.5 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 SOX17
6 hormone activity GO:0005179 9.43 GAST GHRL PPY
7 miRNA binding GO:0035198 9.4 POU5F1 SOX2
8 sequence-specific DNA binding GO:0043565 9.17 FOXA2 NKX6-1 NKX6-2 POU5F1 PTF1A SOX17

Sources for Non-Functioning Pancreatic Endocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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