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Non-hodgkin Lymphoma malady
28 drugs, 610 genes, 23 tissues, 1058 related diseases, 28 phenotypes, 1010 articles, clinical trials.

Summaries for Non-hodgkin Lymphoma

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22MalaCards
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MalaCards: Non-hodgkin Lymphoma, also known as lymphoma, non-hodgkin, is related to leukemia and carcinoma. An important gene associated with Non-hodgkin Lymphoma is BCL7A (B-cell CLL/lymphoma 7A), and among its related pathways are STAT3 Pathway and TNF Superfamily Pathway. The drugs bleomycin sulfate and mitoxantrone and the compounds calcium and oxygen have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and lung, and related mouse phenotypes are cellular and hematopoietic system.

Aliases & Descriptions for Non-hodgkin Lymphoma

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6Disease Ontology, 7diseasecard, 8DISEASES, 43UMLS, 33OMIM, 32Novoseek
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Aliases & Descriptions:

non-hodgkin lymphoma 6 7 8
lymphoma, non-hodgkin 33 43
lymphoma non-hodgkins 32
lymphoma 43

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Related Diseases for Non-hodgkin Lymphoma

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13GeneCards, 14GeneDecks
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Diseases related to non-hodgkin lymphoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1055)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia79.9PIM2, PIK3CA, PIM1, SH2D1A, RFC1, NCF2
2carcinoma71.5PIM2, PIK3CA, PIM1, RFC1, NCF2, NCOR2
3lymphocytic leukemia64.0PIM2, PIK3CA, REL, RELB, KIR2DL1, KIR2DL3
4diffuse large b-cell lymphoma57.7PIK3CA, PIM1, REL, CNR2, RB1, NBN
5b-cell non-hodgkin lymphoma57.5SH2D1A, RB1, RBBP7, VEGFA, MYC, BMI1
6prostatitis57.3PIM2, PIK3CA, PIM1, RFC1, NCOR2, PDCD1
7myeloid leukemia53.7PIM2, PIK3CA, PIM1, NCOR2, PDCD1, KIR2DS3
8adenocarcinoma53.1PIM2, PIK3CA, PIM1, CNR1, KITLG, PCNA
9hepatocellular carcinoma52.1PIM2, PIK3CA, PDCD1, RELB, CNR1, CNR2
10hodgkin's lymphoma51.8SH2D1A, REL, BSG, BRCA1, BMI1, RAG1
11myeloma50.8PIM2, PIK3CA, NCOR2, REL, RELB, KITLG
12arthritis50.5SH2D1A, RFC1, NCF4, PDCD1, REL, RELB
13pancreatitis50.1PIK3CA, PIM1, NCF2, CNR1, CNR2, KITLG
14gastric cancer50.0PIK3CA, PIM1, RFC1, PCNA, RB1, SELE
15melanoma49.9PIK3CA, PIM1, PDCD1, REL, RELB, KIR3DL2
16multiple myeloma49.8PIK3CA, NCOR2, REL, RELB, KITLG, KIR3DS1
17neuronitis49.3PIK3CA, PIM1, SH2D1A, NCF2, NCF4, NCOR2
18lymphoblastic leukemia49.2PIK3CA, RFC1, KITLG, KIR3DL1, PCNA, RB1
19leukemia/lymphoma48.2PIM2, PIK3CA, RFC1, PDCD1, REL, KITLG
20chronic lymphocytic leukemia48.0REL, SELL, MYB, BIRC2, BIRC3, BIRC5
21b-cell lymphomas46.9PIM1, REL, CNR1, RB1, NBN, MYC
22lupus erythematosus46.8NCF2, PDCD1, REL, KIR2DS3, KIR2DS5, KIR2DL1
23acute leukemia46.7PIK3CA, NCOR2, KITLG, RB1, SELL, NAT2
24thyroiditis46.5PIK3CA, RFC1, NCOR2, CNR2, KITLG, PCNA
25adult t-cell leukemia45.6PIM1, KIR2DL1, KIR2DL3, MYC, MYB, PAX5
26follicular lymphoma45.3REL, MYC, MYB, BMI1, BIRC2, BIRC3
27cervicitis45.1PIK3CA, RFC1, PDCD1, CNR1, KIR3DL2, KIR2DL1
28tuberculosis45.0PIM2, PIM1, SH2D1A, PDCD1, RELB, KIR2DL1
29lung carcinoma44.9PIK3CA, PCNA, RB1, RBL2, NBN, SELL
30acute myeloid leukemia44.4PIM2, PIK3CA, PIM1, NCOR2, KIR2DL3, KITLG
31burkitt's lymphoma44.2SH2D1A, MYC, MYCN, MYB, BMI1, BMP6
32mantle cell lymphoma44.1PIM2, PIK3CA, PIM1, CNR1, CNR2, RB1
33sarcoma42.7PIK3CA, RELB, KITLG, PCNA, RB1, RBL2
34acute lymphoblastic leukemia42.2KITLG, KIR3DL1, RB1, NBN, SELL, LMO2
35colon cancer42.1PIK3CA, RFC1, NCOR2, CNR1, CNR2, PCNA
36squamous cell carcinoma41.9PIK3CA, PIM1, PCNA, RB1, RBL2, NBN
37neuroblastoma41.8PIK3CA, NCF2, NCOR2, CNR1, KIR2DS3, KIR2DS5
38central nervous system lymphoma41.8PIM1, RB1, VEGFA, MYC, BIRC5, PAX5
39nasopharyngitis41.4PIK3CA, PDCD1, RELB, KIR2DS5, KIR2DL1, KIR2DL3
40malt lymphoma41.3MYC, BIRC2, BIRC3, BCL10, BCL2, BCL6
41cutaneous t cell lymphoma41.3SELE, SELL, MYB, BIRC5, BAX, CDKN2B
42leukemia/lymphoma, t-cell40.4PIM2, KITLG, RB1, NBN, MYC, MYCN
43peripheral t-cell lymphoma40.3PAX5, BCL3, BCL6, LEF1, MS4A1, CD5
44anemia39.1PIM1, SH2D1A, PDCD1, KITLG, PCNA, RB1
45immunodeficiency39.0PDCD1, KIR3DL1, SELL, BMP6, PARP1, BCR
46anaplastic large cell lymphoma38.9PIK3CA, PCNA, RB1, BSG, MYC, BIRC2
47t-cell leukemia38.8REL, LMO2, MYC, MYB, RAG1, RAF1
48breast carcinoma38.7PIK3CA, CNR2, KITLG, PCNA, RB1, RBL2
49primary effusion lymphoma38.7PIK3CA, SELL, SELPLG, BSG, VEGFA, VDR
50hypoxia38.4PIK3CA, PIM1, KITLG, PCNA, RB1, NBN

Graphical network of the top 20 diseases related to non-hodgkin lymphoma:



Graphical network of diseases related to non-hodgkin lymphoma

Clinical Features for Non-hodgkin Lymphoma

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Drugs & Therapeutics for Non-hodgkin Lymphoma

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for non-hodgkin lymphoma

Drug clinical trials:

Search ClinicalTrials for non-hodgkin lymphoma

Search NIH Clinical Center for non-hodgkin lymphoma

Search CenterWatch for non-hodgkin lymphoma

Inferred drug relations via UMLS/NDF-RT:

43 28 aldesleukin, asparaginase, bleomycin, bleomycin sulfate, carmustine, chlorambucil, cisplatin, cisplatin pwdr [va product], cladribine, cytarabine, cytarabine liposome, doxorubicin hydrochloride, fludarabine, fludarabine phosphate, ifosfamide, irinotecan, irinotecan hydrochloride, lomustine, mercaptopurine, mitoxantrone, mitoxantrone hydrochloride, pegaspargase, procarbazine, procarbazine hydrochloride, sargramostim, thiotepa, vincristine, vincristine sulfate

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-Cell-Based therapeutic approaches for non-hodgkin lymphoma:
Blood stem cell transplantation in Hodgkin's/non-Hodgkin's lymphoma, multiple myeloma or chronic lymphocytic leukemia patients
Embryonic/Adult Cultured Cells Related to non-hodgkin lymphoma:
Peripheral blood/mobilized hematopoietic stem cells, PMIDs: 19015394, 17916744, 18794548

Genetic Tests for Non-hodgkin Lymphoma

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Anatomical Context for Non-hodgkin Lymphoma

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21LifeMap Discovery™, 22MalaCards
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MalaCards organs/tissues related to non-hodgkin lymphoma:

22
Brain, Kidney, Lung, Spleen, Lymph node, Bone marrow, Heart, Small intestine, Colon, Thyroid, Breast, Prostate, Testis, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Testis germ

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Embryonic and adult cells/anatomical compartments related to non-hodgkin lymphoma:
id Organ / Tissue -> Anatomical Compartment -> Cell Relevance
1 Bone -> Bone Marrow -> Hematopoietic Stem Cells Potential therapeutic candidate
2 Blood -> Peripheral Blood -> Mature B Cells Potential therapeutic candidate, affected by disease

Phenotypes for genes affiliated with Non-hodgkin Lymphoma

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25MGI
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MGI Mouse Phenotypes related to non-hodgkin lymphoma:

25 (show all 28)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1cellular phenotypeMP:000538428.0PIM2, PIK3CA, PIM1, SH2D1A, NCOR2, PDCD1
2hematopoietic system phenotypeMP:000539726.2PIM2, PIM1, SH2D1A, PDCD1, PCNA, NBN
3mortality/agingMP:001076823.6PIK3CA, NCF4, NCOR2, PDCD1, REL, RELB
4homeostasis/metabolism phenotypeMP:000537622.4PIK3CA, NCOR2, REL, RELB, CNR1, KITLG
5immune system phenotypeMP:000538722.1PIM2, SH2D1A, NCF4, REL, RELB, CNR2
6growth/size phenotypeMP:000537820.6PIM2, PIK3CA, PIM1, NCOR2, REL, RELB
7integument phenotypeMP:001077117.5REL, RELB, CNR1, CNR2, KITLG, RB1
8normal phenotypeMP:000287317.2RBL2, SELE, SERPING1, NAT1, BRAF, BRCA1
9nervous system phenotypeMP:000363116.8PDCD1, REL, CNR1, KITLG, RB1, RBL2
10tumorigenesisMP:000200616.2PIK3CA, KITLG, RB1, RBL2, NBN, SELL
11cardiovascular system phenotypeMP:000538516.0PIK3CA, NCOR2, PDCD1, REL, RELB, KITLG
12digestive/alimentary phenotypeMP:000538115.5NCOR2, REL, RELB, KITLG, RB1, BRAF
13reproductive system phenotypeMP:000538915.4PIK3CA, RBL2, NBN, NAT1, BRCA1, VEGFA
14behavior/neurological phenotypeMP:000538615.0PIK3CA, NCOR2, RELB, CNR1, RB1, NBN
15embryogenesis phenotypeMP:000538014.8PIK3CA, REL, RBBP7, RBL2, NBN, NAT1
16skeleton phenotypeMP:000539014.4REL, CNR1, KITLG, RB1, RBL2, BRAF
17no phenotypic analysisMP:000301213.9CNR1, PCNA, RB1, RBL2, VEGFA, MYC
18renal/urinary system phenotypeMP:000536713.8PDCD1, SELPLG, BRAF, BRCA1, LMO2, MYCN
19endocrine/exocrine gland phenotypeMP:000537913.8RELB, RBL2, NBN, SELL, BRCA1, RAD50
20liver/biliary system phenotypeMP:000537013.6NCOR2, REL, RELB, VEGFA, LMO2, MYCN
21craniofacial phenotypeMP:000538213.6NCOR2, KITLG, NBN, MYCN, BMI1, RASA1
22respiratory system phenotypeMP:000538813.3REL, RELB, SELL, BRCA1, MYCN, RAG1
23vision/eye phenotypeMP:000539112.9PIK3CA, PDCD1, KITLG, RB1, RBL2, SELE
24limbs/digits/tail phenotypeMP:000537112.2RELB, KITLG, RB1, RBL2, BRCA1, VEGFA
25muscle phenotypeMP:000536911.0PIK3CA, PDCD1, RELB, RB1, RBL2, BRAF
26other phenotypeMP:000539510.9RELB, CNR1, CLU, KDR, LEPR, LDLR
27hearing/vestibular/ear phenotypeMP:000537710.8KITLG, RB1, VDR, MYC, RAG1, RASA1
28adipose tissue phenotypeMP:00053758.9PIK3CA, NCOR2, CNR1, RB1, BRAF, BRCA1

Publications for genes affiliated with Non-hodgkin Lymphoma

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35PubMed
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Articles related to non-hodgkin lymphoma:

(show top 50)    (show all 1010)
idTitleAuthorsYearAffiliating Genes
1Serum thymidine kinase 1 concentration as a prognosti c factor of chemotherapy-treated non-Hodgkin's lymphoma patients. (20140744)Pan Z.L.... Skog S.2010TK1
2Absence of tumor-specific over-expression of Polo-lik e kinase 1 (Plk1) in major non-Hodgkin lymphoma and relatively low expression o f Plk1 in nasal NK/T cell lymphoma. (19452252)Imai H.... Oshimi K.2009PLK1
3Pharmacokinetics and pharmacodynamics of plerixafor in patients with non-Hodgkin lymphoma and multiple myeloma. (19135941)Stewart D.A.... Calandra G.2009CSF3
4High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma. (18929412)Green M.... Griffiths L.2009BCL2, BACH2
5Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies. (19414860)Lan Q.... Wang S.S.2009CASP1, CASP3, CASP10
6AMD3100 plus G-CSF can successfully mobilize CD34+ cells from non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma patients previously failing mobilization with chemotherapy and/or cytokine treatment: compassionate use data. (17994119)Calandra G.... Bridger G.2008CSF3
7Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas. (19064398)Schain F.... Sjoberg J.2008CYSLTR1
8One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia. (17891500)Lee K.M.... Armstrong B.K.2007TYMS, CBS, MTR
9Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. (17827388)Cerhan J.R.... Slager S.L.2007ITGB3, CREB1, MAP3K5
10A systematic evaluation of the ataxia telangiectasia mutated gene does not show an association with non-Hodgkin lymphoma. (17640065)Sipahimalani P.... Brooks-Wilson A.R.2007ATM
11Early-mid treatment C-reactive protein level is a prognostic factor in aggressive non-Hodgkin's lymphoma. (17635239)Herishanu Y.... Naparstek E.2007CRP
12Tumor necrosis factor promoter gene polymorphism associated with increased susceptibility to non-Hodgkin's lymphomas. (17087739)Bel Hadj Jrad B.... Chouchane L.2007TNF
13Bortezomib sensitizes non-Hodgkin's lymphoma cells to apoptosis induced by antibodies to tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptors TRAIL-R1 and TRAIL-R2. (17875785)Smith M.R.... Joshi I.2007TNFRSF10B, TNFSF10
14Immune mechanisms in non-Hodgkin lymphoma: joint effects of the TNF G308A and IL10 T3575A polymorphisms with non-Hodgkin lymphoma risk factors. (17510437)Wang S.S.... Hartge P.2007TNF, IL10
15Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma. (17096334)Zhu Y.... Zheng T.2007NPAS2
16Polymorphisms in immune function genes and risk of non-Hodgkin lymphoma: findings from the New South Wales non-Hodgkin Lymphoma Study. (17056605)Purdue M.P.... Armstrong B.K.2007TNF
17Inhibitory effect of triptolide on lymph node metastasis in patients with non-Hodgkin lymphoma by regulating SDF-1/CXCR4 axis in vitro. (17049119)Zhang C.... Chen Y.2006CXCR4
18CA125 expression in patients with non-Hodgkin's lymphoma. (16923563)Wei G.... Qiaohua Z.2006MUC16
19Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. (16389181)Rothman N.... Nieters A.2006TNF, IL6, IL2
20t(14;22)(q32;q11) in non-Hodgkin lymphoma and myeloid leukaemia: molecular cytogenetic investigations. (16156854)Aamot H.V.... Heim S.2005BCR, IGH@
21Intensive sequential chemotherapy with hematopoietic growth factor support for non-Hodgkin lymphoma in patients infected with the human immunodeficiency virus. (14770420)Costello R.T.... Gastaut J.A.2004IL3
22Lack of prognostic significance of BCL2 and p53 protein overexpression in elderly patients with diffuse large B-cell non-Hodgkin's lymphoma: results from a population-based non-Hodgkin's lymphoma registry. (15061204)Maartense E.... Noordijk E.M.2004TP53, BCL2
23Mediators of inflammation correlate with microalbuminuria in patients with non-Hodgkin's lymphoma. (12694249)Pedersen L.M.... rensen P.G.2003CRP
24Association between xenobiotic gene polymorphisms and non-Hodgkin's lymphoma risk. (12139735)Kerridge I.... Spencer A.2002CYP1A1, NAT1, GSTT1
25Expression of anaplastic lymphoma kinase in non-Hodgkin's lymphomas and other malignant neoplasms. Biological, diagnostic, and clinical implications. (14569815)Wasik M.A.2002ALK
26Alterations on the 5' noncoding region of the BCL-6 gene are not correlated with BCL-6 protein expression in T cell non-Hodgkin lymphomas. (11742039)Kerl K.... Borisch B.2001BCL6
27Cost-Effectiveness of interferon alfa-2b added to chemotherapy for high-tumor-burden follicular non-Hodgkin's lymphoma. (11426529)Wirt D.P.... Beck J.R.2001IFNA1
28Non-Hodgkin's lymphoma of the ascending colon in a patient with becker muscular dystrophy: report of a case. (11766073)Uotani H.... Tsukada K.2001CHKB
29Differential gene expression in B-cell non-Hodgkin's lymphoma of SIV-infected monkey. (10659056)Tarantul V.Z.... Bodemer W.2000RPS3A, MT-CO2
30Expression of prolactin and prolactin receptors by non-Hodgkin's lymphoma cells. (10585595)Matera L.... Vonderhaar B.K.2000IL2
31The biological markers of non-Hodgkin's lymphomas: their role in diagnosis, prognostic assessment and therapeutic strategy. (10569136)Morra E.1999B2M
32Upregulation of nucleobindin expression in human-activated lymphocytes and non-Hodgkin's lymphoma. (9589460)Kubota T.... Maruyama K.1998NUCB1
33The t(2;3)(q21;q27) translocation in non-Hodgkin's lymphoma displays BCL6 mutations in the 5' regulatory region and chromosomal breakpoints distant from the gene. (9796700)Chen W.... Chaganti R.S.1998BCL6
34Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis. (9531598)Plumas J.... Bensa J.C.1998FAS
35A phase I/II trial of paclitaxel for non-Hodgkin's lymphoma followed by paclitaxel plus quinine in drug-resistant disease. (9510499)Miller T.P.... Salmon S.E.1998ABCB1
36Analysis of p53 gene deletions in patients with non-Hodgkin's lymphoma by dual-colour fluorescence in-situ hybridization. (9326189)Clodi K.... Andreeff M.1997TP53
37Frequent hepatic involvement in adult T cell leukemia: comparison with non-Hodgkin's lymphoma. (9322895)Yamada Y.... Tomonaga M.1997GPT
38Expression of cytotoxic molecules in intestinal T-cell lymphomas. The German Study Group on Intestinal Non-Hodgkin Lymphoma. (9349234)Daum S.... Stein H.1997GZMB
39HOXC4, HOXC5, and HOXC6 expression in non-Hodgkin's lymphoma: preferential expression of the HOXC5 gene in primary cutaneous anaplastic T-cell and oro-gastrointestinal tract mucosa-associated B-cell lymphomas. (9354682)Bijl J.J.... Meijer C.J.1997HOXC6, HOXC4, HOXC5
40Recombinant human erythropoietin in transfusion-depen dent anemic patients with multiple myeloma and non-Hodgkin's lymphoma--a random ized multicenter study. The European Study Group of Erythropoietin (Epoetin Bet a) Treatment in Multiple Myeloma and Non-Hodgkin's Lymphoma. (8639883)Osterborg A.... Peest D.1996EPO
41High-dose CHOP as initial therapy for patients with p oor-prognosis aggressive non-Hodgkin's lymphoma: a dose-finding pilot study. (8523055)Shipp M.A.... Shulman L.N.1995CSF3
42Granulocyte colony-stimulating factor (G-CSF) allows the delivery of effective doses of CHOP and CVP regimens in non-Hodgkin lymphomas. (7540461)Silvestri F.... Baccarani M.1995CSF3
43Molecular cloning of a novel 11q23 breakpoint associated with non-Hodgkin's lymphoma. (8108133)Meerabux J.M.... Young B.D.1994MLL, DDX6
44Salvage chemotherapy for relapsed/refractory aggressive non-Hodgkin's lymphoma with a combination of dexamethasone, etoposide, ifosfamide and carboplatin (8065017)Okamoto M.... Ino T.1994CSF3
45Non-Hodgkin's lymphoma in four children infected with the human immunodeficiency virus. Association with Epstein-Barr Virus and trea tment. (8275430)Nadal D.... Seger R.A.1994TRB@
46Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44. (8459220)Koopman G.... Pals S.T.1993CD44
47Detection of oncogene rearrangements in human non-Hodgkin's lymphomas. (1485535)Kondo E.... Takahashi K.1992MYC, BCL2, CCND1
48Immunohistochemical determination of glycoprotein P in 60 non-Hodgkin's lymphomas (1684340)Pileri S.... Baccarani M.1991ABCB11
49Molecular pathogenesis of AIDS-associated non-Hodgkin's lymphoma. (2022596)Shiramizu B.... McGrath M.S.1991MYC
50Analysis of T-cell receptor and immunoglobulin gene rearrangements in the diagnosis of Hodgkin's and non-Hodgkin's lymphoma. (2391586)Gledhill S.... Jarrett R.F.1990TRB@

Expression for genes affiliated with Non-hodgkin Lymphoma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Non-hodgkin Lymphoma

Pathways for genes affiliated with Non-hodgkin Lymphoma

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36QIAGEN, 20KEGG, 10EMD Millipore, 41Thomson Reuters, 37R&D Systems
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Pathways related to non-hodgkin lymphoma according to GeneDecks:

(show top 50)    (show all 262)
idPathwayScoreTop Affiliating Genes
1STAT3 Pathway3615.0PIM1, BRAF, MYC, BMP6, RAF1, RAC1
2TNF Superfamily Pathway3613.4CHUK, MAPK11, IKBKB, CASP7, CASP10, CASP3
3Cytokine-cytokine receptor interaction2012.9KITLG, VEGFA, VEGFC, KDR, LEP, LEPR
4Apoptosis and survival FAS signaling cascades1012.7BID, BIRC2, PARP1, BCL2, BCL2L11, BAX
5Small cell lung cancer2012.7PIK3CA, RB1, MYC, BIRC2, BIRC3, BCL2
6Apoptosis and survival_FAS signaling cascades4112.7BID, BIRC2, PARP1, BCL2, BCL2L11, BAX
7Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins1012.6RAF1, BID, BIK, BCL2, BCL2A1, BCL2L1
8PEDF Induced Signaling3612.6BRAF, BMP6, RAF1, BCL2, BCL2L1, CHUK
9Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins4112.6RAF1, BID, BIK, BCL2, BCL2A1, BCL2L1
10RAR-Gamma-RXR-Alpha Degradation3612.5CD80, IL12A, IL15, IL16, IL2, IL3
11TRAF Pathway3612.5BIRC2, BIRC3, CHUK, IL12A, IL12B, IL1A
12Signal transduction_AKT signaling4112.5PIK3CA, REL, RELB, PCNA, MYC, BCL2L1
13Apoptotic Pathways Triggered By HIV13612.5BID, BIRC2, BIRC3, BCL2, BCL2L1, CHUK
14Apoptosis and survival APRIL and BAFF signaling1012.4RELB, BCL2, BCL2A1, BCL2L1, CHUK, FCER2
15Development_Notch Signaling Pathway4112.3NCOR2, REL, RBBP7, FBXW7, TP63, TP73
16Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway4112.2REL, RELB, BIRC2, BIRC3, BIRC5, CHUK
17Viral myocarditis2012.2RAC1, RAC2, BID, CD28, CD86, CD40LG
18TNF Signaling3612.2BID, BIRC2, BIRC3, CHUK, BAG4, APAF1
19Apoptosis through Death Receptors3612.2BID, BIRC2, BIRC3, BCL2, CHUK, BAX
20Development Notch Signaling Pathway1012.1NCOR2, REL, RBBP7, FBXW7, TP73, DLL1
21Immune response_BCR pathway4112.1PIK3CA, REL, RELB, RAC1, BCL2L1, BCL6
22Cell cycle Cell cycle (generic schema)1012.0RB1, RBL2, CDK6, CDK2, CDC25C, CDC25B
23Development_NOTCH1-mediated pathway for NF-KB activity modulation4112.0NCOR2, REL, RELB, RBBP7, CHUK, IL1A
24Cell cycle_Cell cycle (generic schema)4112.0RB1, RBL2, CDK6, CDK2, CDC25C, CDC25B
25Autoimmune thyroid disease2011.8CD28, CD86, CD40LG, CD80, CD40, GZMB
26Ceramide Pathway3611.8RAF1, BAD, CASP7, CASP10, CASP3, CASP4
27G1-S Phase Transition3611.7RB1, ATM, CDK6, CDKN1A, CDKN2C, CDK2
28T cell receptor signaling pathway2011.7PIK3CA, PDCD1, RAF1, BCL10, CHUK, CD28
29Cyclins and Cell Cycle Regulation3611.7RB1, RAF1, ATM, CDK6, CDKN1A, CDKN2C
30Rho Family GTPases3611.6NCF2, KITLG, VEGFC, BMP6, RAF1, RAC1
31Toxoplasmosis2011.6PIK3CA, BIRC2, BIRC3, BCL2, BCL2L1, CHUK
32PAK Pathway3611.6KITLG, VEGFC, BMP6, RAC1, RAC2, KDR
33TNFR1 Pathway3611.5BID, BIRC2, BIRC3, CHUK, BAG4, APAF1
34Acute myeloid leukemia2011.5PIM2, PIK3CA, PIM1, BRAF, MYC, RAF1
35DR3 Signaling3611.5BID, BIRC2, BIRC3, CHUK, BAG4, APAF1
36Development_IGF-1 receptor signaling4111.3PIK3CA, REL, RELB, MYC, RAF1, BCL2L1
37Development IGF-RI signaling1011.2PIK3CA, REL, RELB, MYC, RAF1, BCL2L1
38Signal transduction AKT signaling1011.2REL, RELB, IRS1, IKBKB, NFKB2
39Chronic myeloid leukemia2011.0PIK3CA, RB1, BRAF, MYC, RAF1, BCL2L1
40DHA Signaling3611.0KITLG, VEGFC, BMP6, BID, BIK, KDR
41Rheumatoid arthritis2010.9VEGFA, CD28, CD86, CD80, ITGB2, FLT1
42TGF-Beta Pathway3610.8KITLG, VEGFC, BMP6, KDR, BCL2, BAX
43Chagas disease (American trypanosomiasis)2010.8PIK3CA, CHUK, CFLAR, IL10, IL12A, IL12B
44Cellular Apoptosis Pathway3610.8KITLG, VEGFC, BMP6, BID, BIRC2, KDR
45Colorectal Cancer Metastasis3610.7BRAF, MYC, BIRC5, BCL2L1, LEF1, BAX
46Type I diabetes mellitus2010.7CD28, CD86, CD80, GZMB, INS, IL12A
47p53 Mediated Apoptosis3610.6KITLG, VEGFC, BMP6, BID, KDR, BCL2
48NF-KappaB Family Pathway3610.3REL, RELB, KITLG, VEGFC, BMP6, KDR
49TGF-beta Signaling Pathways3710.1NCOR2, REL, RELB, BRAF, MYC, RAF1
50p70S6K Signaling368.6KITLG, VEGFC, BMP6, RAF1, RAC1, RAC2

Compounds for genes affiliated with Non-hodgkin Lymphoma

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to non-hodgkin lymphoma according to GeneDecks:

(show top 50)    (show all 465)
idCompoundScoreTop Affiliating Genes
1calcium32 9 18 9 25.9PIM1, SH2D1A, NCF2, REL, CNR1, KITLG
2oxygen32 18 20.3NCF2, NCF4, KITLG, RB1, SELPLG, BRCA1
3atp32 17.6PIK3CA, PIM1, RFC1, NCF2, KIR3DL1, RB1
4actinomycin d32 14.0PIK3CA, KITLG, RB1, SELE, VEGFA, VDR
55fluorouracil32 13.8PIK3CA, KITLG, PCNA, RB1, SELE, BRCA1
6fludarabine32 9 9 15.8BID, BIRC2, BIRC3, BIRC5, PARP1, BCL2
7cholesterol32 9 18 9 16.6PIK3CA, CNR2, KITLG, RB1, SELE, SELPLG
8adp32 18 14.5PIM2, PIK3CA, PIM1, RFC1, SELPLG, BRAF
912-o-tetradecanoylphorbol 13-acetate32 13.3RB1, BRAF, MYC, BMP6, RAG1, RAF1
10daunorubicin32 9 9 14.9KITLG, MYC, RAF1, BIRC5, BCL2, BCL2L1
11dutp32 12.8PCNA, BIRC5, CLU, PARP1, BCL2, BCL2L1
12lactate32 12.5PIK3CA, KITLG, PCNA, SELE, SELL, BSG
13calcitriol32 42 9 18 9 16.5KITLG, RB1, VDR, MYC, BMP6, CLU
14gemcitabine32 34 9 9 15.4PCNA, BRCA1, VEGFA, BNIP3, MYC, BID
15valine32 12.3BRAF, RAF1, RAC1, MTHFR, MTR, B2M
16lovastatin32 42 9 9 15.1RB1, RAF1, RAC1, CHKB, LDLR, XIAP
17matrigel32 12.0PIK3CA, RB1, SELE, BSG, BRAF, VEGFA
18lysine32 11.9REL, KIR3DL1, SET, BRCA1, MYB, CHKB
19adenylate32 11.8PIK3CA, CNR1, CNR2, KITLG, SELE, VDR
20chloramphenicol32 9 9 13.8REL, SELE, VDR, MYC, MYCN, MYB
21sp 60012532 42 12.7BID, BIK, BIRC2, BIRC3, CDKN1A, CD40
22indole-3-carbinol32 11.7BRCA1, BIRC5, PARP1, BCL2, BCL2L1, BAX
23okt332 11.7SELE, BMP6, LBR, CD79A, CD40LG, ITGB2
24azathioprine32 34 9 9 14.6PCNA, RAC1, CHKB, MTHFR, CD79A, CDKN2B
25isoproterenol32 9 9 13.6SELL, BRAF, RAF1, LBR, AR, INSR
26phenobarbital32 9 9 13.6PCNA, MYC, GSTM1, GPT, ALPP, AKR1A1
27fatty acid32 11.6BRAF, BRCA1, BNIP3, MYB, CLU, LEP
28pentoxifylline32 9 9 13.5SELL, BMP6, LBR, MPO, CD14, ITGA4
29dopamine32 9 18 9 14.5PIK3CA, SELE, MYCN, BMP6, RAF1, CLU
30theophylline32 9 18 9 14.5SELL, MYC, RAF1, CHKB, B2M, CD79A
31geldanamycin32 9 9 13.4PIM1, BRAF, VEGFA, RAF1, BIRC5, PARP1
32thapsigargin32 42 12.4CNR1, PCNA, MYB, RAF1, BCL2, BCL2L1
33simvastatin32 34 42 9 18 9 16.4KITLG, SELE, SELL, VEGFA, BMP6, RAC1
34nocodazole32 42 9 9 14.4BRCA1, RAF1, RAN, RAC1, BIRC5, CHEK2
35retinoid32 11.4NCOR2, SELL, VDR, MYC, MYCN, MYB
36phenylalanine32 11.4SELPLG, RASA1, BCR, LBR, CD28, MME
37formaldehyde32 18 12.3PCNA, RB1, SELE, SELL, MUC1, B2M
38agar32 11.2PIK3CA, KITLG, RB1, BRAF, BRCA1, MYCN
39mannitol32 9 9 12.9CHKB, B2M, CD40LG, CDKN3, IRS1, FGF2
40fluvastatin32 34 9 9 13.9RAC1, CHKB, LDLR, CD40, MMP9, IL1A
41chloroquine32 34 9 9 13.8BRCA1, BMP6, RAF1, LDLR, B2M, CD79A
42peroxynitrite32 10.6NAT1, PARP1, CHKB, MPO, CDC25C, GSR
43polyethylene glycol32 10.6KITLG, SELE, CHKB, MUC1, MPO, INSR
44il-1232 10.5CD86, CD40LG, IL10, IL12B, IL13, IL15
45pravastatin32 34 9 18 9 14.1SELE, RAC1, CHKB, LDLR, IL6, CYP2D6
46pge232 10.1SELE, RAF1, RAC1, LDLR, MT-CO2, CD69
47sodium nitroprusside32 10.0PCNA, MYB, BMP6, CD40, MME, IRS1
48rottlerin32 42 10.9RAC1, PARP1, XIAP, CDK6, CD36, CD40LG
49diphenyleneiodonium32 9.9NCF2, VEGFA, RAC1, MPO, CDKN3, INSR
50pioglitazone32 9 9 11.5NCOR2, BSG, VEGFA, LEP, CFD, CD40

GO Terms for genes affiliated with Non-hodgkin Lymphoma

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Sources:
12Gene Ontology
See all sources

Cellular components related to non-hodgkin lymphoma according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573720.9PIM1, SH2D1A, NCF2, KITLG, PCNA, RBL2
2plasma membraneGO:00588620.8PIM1, PDCD1, CNR1, CNR2, KIR3DL2, KIR2DL1
3nucleusGO:00563420.6PIM1, NCOR2, RELB, PCNA, RB1, RBL2
4cytosolGO:00582919.8PIK3CA, NCF2, NCF4, REL, RELB, SET
5integral to plasma membraneGO:00588716.9CNR1, CNR2, KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1
6external side of plasma membraneGO:00989714.6SELL, KDR, LDLR, B2M, CD28, CD79A
7nucleoplasmGO:00565414.2RFC1, NCOR2, REL, PCNA, RB1, RBBP7
8extracellular regionGO:00557612.0KITLG, SERPING1, VEGFA, VEGFC, CLU, KDR
9cell surfaceGO:00998611.2VEGFA, LDLR, CD36, CD14, CD59, CD44
10extracellular spaceGO:00561510.8KITLG, SELE, VEGFA, VEGFC, BMP6, CLU
11membrane raftGO:0451219.8SELE, BSG, BCL10, CD79A, CD36, CD14

Biological processes related to non-hodgkin lymphoma according to GeneDecks:

(show top 50)    (show all 60)
idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:00691516.9PIM1, PDCD1, NBN, BRCA1, BNIP2, BNIP3
2immune responseGO:00695516.6NCF4, CNR2, KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1
3innate immune responseGO:04508714.8NCF2, SERPING1, CLU, BCL10, BCL2, BCL2L1
4signal transductionGO:00716514.5PDCD1, KITLG, VEGFC, VDR, RAF1, RAN
5induction of apoptosisGO:00691713.9BNIP3, BIK, BCL10, BCL2L11, BCL2L13, BCLAF1
6regulation of immune responseGO:05077613.5KIR3DL2, KIR2DL1, KIR2DL3, KIR3DL1, KIR2DS2, KIR2DS1
7anti-apoptosisGO:00691613.2PIM2, PIK3CA, BRAF, BNIP2, BNIP3, BIRC2
8virus-host interactionGO:01904813.2RB1, BNIP3, RAN, BECN1, KDR, LDLR
9response to DNA damage stimulusGO:00697412.8BRCA1, MYC, RAD50, BLM, BCL2, BCL3
10cell proliferationGO:00828312.7PIM2, PIM1, KITLG, PCNA, RBBP7, NBN
11positive regulation of apoptotic processGO:04306512.7CNR1, BID, CLU, BCL2L11, BCL6, BCLAF1
12complement activation, classical pathwayGO:00695812.6SERPING1, CLU, CD55, CD46, MBL2, MASP2
13induction of apoptosis by intracellular signalsGO:00862912.5BNIP3, MYC, BID, CLU, BCL2, BCL2L1
14activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691912.4MYC, BCL2L10, BCL2L11, BCL2L13, BAD, BAX
15cellular defense responseGO:00696812.4SH2D1A, NCF2, KIR2DS3, KIR3DL2, BECN1, BCL10
16induction of apoptosis by extracellular signalsGO:00862412.4VDR, RAC1, BCL2L11, BAD, BAK1, BAX
17activation of pro-apoptotic gene productsGO:00863312.4MYC, BID, BCL2, BCL2L11, BAD, BAK1
18complement activationGO:00695612.3CLU, CFB, CFD, CFH, CFHR1, MBL2
19regulation of apoptotic processGO:04298112.3BRCA1, RAF1, BIRC5, BCL2L14, BCL3, FLT3
20positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312312.1PIM2, REL, BIRC2, BIRC3, BCL10, CHUK
21positive regulation of transcription from RNA polymerase II promoterGO:04594412.1RB1, BRCA1, VEGFA, VDR, LMO2, MYC
22inflammatory responseGO:00695412.0CNR2, SELE, BMP6, RAC1, CHUK, S100A8
23response to drugGO:04249312.0NCF2, NBN, VEGFC, MYC, BCL2, MVP
24release of cytochrome c from mitochondriaGO:00183611.9MYC, BID, CLU, BCL2, BCL2L1, BAK1
25negative regulation of apoptotic processGO:04306611.9PIM1, BRAF, VEGFA, MYC, RAF1, BIRC2
26positive regulation of B cell proliferationGO:03089011.9BCL2, BCL6, CDKN1A, CD40LG, CD40, CD38
27cellular response to mechanical stimulusGO:07126011.8BNIP3, BCL10, BAD, BAK1, CD40, ITGB1
28response to organic cyclic compoundGO:01407011.8NCF2, LEF1, BAK1, MSH2, CDKN1A, CDK1
29positive regulation of transcription, DNA-dependentGO:04589311.8PIM2, REL, RB1, BRCA1, MYC, MYB
30positive regulation of neuron apoptotic processGO:04352511.7NCF2, BCL2L11, BAG1, BAX, ATM, FASLG
31response to lipopolysaccharideGO:03249611.6NCF2, CNR1, CNR2, SELE, S100A8, MMP9
32response to toxinGO:00963611.5BCL2, BAX, XPA, CDKN1A, CDK1, ASNS
33cell surface receptor signaling pathwayGO:00716611.4BSG, BIRC2, BIRC3, LEPR, BAG1, CD28
34cytokine-mediated signaling pathwayGO:01922111.2BAD, B2M, CEBPA, CD44, IRF4, FLT3
35negative regulation of cell proliferationGO:00828511.1PIM2, VDR, RAF1, BECN1, BCL6, BAK1
36positive regulation of cell proliferationGO:00828411.0NBN, VEGFA, VEGFC, MYC, RAC2, BIRC5
37phosphatidylinositol-mediated signalingGO:04801510.9PIK3CA, PCNA, CHUK, BAD, MTOR, AURKA
38organ regenerationGO:03110010.8LEF1, LCP1, BAK1, CEBPA, CDKN1A, CDK1
39fibroblast growth factor receptor signaling pathwayGO:00854310.6PIK3CA, BRAF, RAF1, CHUK, BAD, MTOR
40positive regulation of NF-kappaB transcription factor activityGO:05109210.6CLU, BCL10, CHUK, CD40, AR, INS
41nerve growth factor receptor signaling pathwayGO:04801110.6PIK3CA, BRAF, RAF1, RAC1, BCL2L11, CHUK
42activation of MAPK activityGO:00018710.6CDK1, INSR, FGF2, IL1B, MAPK11, MAPK1
43response to ethanolGO:04547110.4CNR1, BCL2, BAK1, S100A8, CD27, CDK1
44agingGO:00756810.2NCF2, CNR1, VDR, BAK1, IL15, IL1B
45response to hypoxiaGO:00166610.1VEGFA, BNIP3, RAF1, BCL2, LEP, ATM
46blood coagulationGO:00759610.1PIK3CA, SELL, SELPLG, SERPING1, BSG, VEGFA
47positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.8KITLG, VEGFA, MTOR, CD36, CD80, CD44
48platelet activationGO:0301689.1PIK3CA, SERPING1, VEGFA, VEGFC, RAF1, RAC1
49positive regulation of nitric oxide biosynthetic processGO:0454298.6INS, INSR, IL1B, IFNG, ICAM1, HSP90AA1
50MAPK cascadeGO:0001658.6MYC, RAF1, CDK1, INS, FGFR1, IL1B

Molecular functions related to non-hodgkin lymphoma according to GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551527.7SKI, ABL1, ABT1, C6, EIF4E, H2AFX
2protein kinase bindingGO:01990113.5PTEN, TP73, TP53, IKBKB, CCND1, CCND3
3receptor activityGO:00487212.6ICAM1, HTR3A, TNFRSF10A, TNFRSF10B, TNFRSF13B, TNFRSF17
4protein homodimerization activityGO:04280312.4CRP, RIPK2, WRN, ADIPOQ, EPHX2, CPQ
5identical protein bindingGO:04280212.2TNF, TP73, TP63, TP53, TRADD, TRAF2
6protein heterodimerization activityGO:04698212.1TOP2A, AHR, EGFR, CYBA, OTX2, TP53
7receptor bindingGO:00510212.0LTA, NOS2, CTNND1, TNFSF8, TNFSF13B, TNFSF10
8cytokine activityGO:00512511.5KITLG, VEGFA, BMP6, CD70, CD40LG, FLT3LG
9transmembrane signaling receptor activityGO:00488811.2TNFRSF8, SPN, CR2, EGFR, TLR1, TLR10
10enzyme bindingGO:01989910.5NOTCH1, NOD2, PPARG, CYP2E1, CYP2C19, CYP1A2

Sources for Non-hodgkin Lymphoma

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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