MCID: NNH001
MIFTS: 66

Non-Hodgkin Lymphoma malady

Genetic diseases (common), Cancer diseases, Immune diseases categories
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Summaries for Non-Hodgkin Lymphoma

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47OMIM, 33MalaCards
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MalaCards: Non-Hodgkin Lymphoma, also known as lymphoma, non-hodgkin, is related to leukemia and chronic lymphocytic leukemia. An important gene associated with Non-Hodgkin Lymphoma is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Direct p53 effectors and FoxO signaling pathway. The drugs cisplatin and cisplatin pwdr and the compounds methylmethanesulfonate and mycophenolate mofetil have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Description from OMIM:47 605027

Aliases & Classifications for Non-Hodgkin Lymphoma

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8Disease Ontology, 31LifeMap Discovery™, 9diseasecard, 47OMIM, 62UMLS, 45Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

non-hodgkin lymphoma 8 31
lymphoma, non-hodgkin 9 47 62
lymphoma non-hodgkins 45


External Ids:

Disease Ontology8 DOID:0060060
OMIM47 605027
ICD1025 C85.7

Related Diseases for Non-Hodgkin Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Non-Hodgkin Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.5IGH, NBN, HPRT1, BCL6, CSF3, CASP10
2chronic lymphocytic leukemia31.2IGH, IGK, MS4A1, BCL6, CASP10, MDM2
3mantle cell lymphoma31.1BCL6, MDM2
4multiple myeloma31.0CSF3
5myeloma31.0IGH, BCL6, CSF3, LTA
6b-cell chronic lymphocytic leukemia30.8MS4A1, IGH
7burkitt's lymphoma30.8IGH, MS4A1, BCL6, MDM2
8familial non-hodgkin lymphoma30.7BRAF, CASP10
9lymphoblastic lymphoma30.7BCL6, MS4A1
10ataxia telangiectasia30.6MDM2, HPRT1, NBN
11follicular lymphoma30.6BCL6, MS4A1, IGH
12colorectal cancer30.5MDM2, HPRT1, BRAF, NBN
13breast cancer30.5NBN, BRAF, HPRT1, BCL6, CSF3, CASP10
14lymphoma, diffuse large cell30.3MS4A1, BCL6
15lung cancer30.3NBN, BRAF, HPRT1, CSF3, GSTM3, MDM2
16hodgkin's lymphoma30.3IGH, MS4A1, BCL6, CSF3, MDM2, LTA
17melanoma30.2NBN, BRAF, PRF1, HPRT1, CASP10, MDM2
18b-cell lymphomas30.2IGH, NBN, PRF1, MS4A1, BCL6, MDM2
19hepatitis10.8
20hepatitis c10.6
21hepatitis b10.5
22lymphoblastic leukemia10.5
23hematopoietic stem cell transplantation10.5
24neutropenia10.5
25pneumonia10.5
26cryoglobulinemia10.4
27acquired immunodeficiency syndrome10.4
28autoimmune hemolytic anemia10.4
29obstructive jaundice10.4
30hemolytic anemia10.4
31sarcoma10.4
32hepatitis c virus10.4
33endotheliitis10.4
34progressive multifocal leukoencephalopathy10.4
35acute leukemia10.4
36hairy cell leukemia10.4
37histiocytosis10.4
38meningitis10.4
39prostatitis10.4
40renal cell carcinoma10.4
41non-hodgkin lymphoma, during pregnancy10.4
42hepatitis b virus infection10.4
43langerhans-cell histiocytosis10.3
44panhypopituitarism10.3
45pemphigus10.3
46intussusception10.3
47kaposi's sarcoma10.3
48mycosis fungoides10.3
49invasive aspergillosis10.3
50wiskott-aldrich syndrome10.3

Graphical network of the top 20 diseases related to Non-Hodgkin Lymphoma:



Diseases related to non-hodgkin lymphoma

Symptoms for Non-Hodgkin Lymphoma

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47OMIM
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Clinical features from OMIM:

605027

Drugs & Therapeutics for Non-Hodgkin Lymphoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Genetic Tests for Non-Hodgkin Lymphoma

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Anatomical Context for Non-Hodgkin Lymphoma

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31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Non-Hodgkin Lymphoma:

33
B cells, T cells, Bone, Bone marrow, Breast, Myeloid, Endothelial, Prostate, Skin, Monocytes, Heart, Thyroid, Liver, Brain, Spinal cord, Tongue, Lymph node, B lymphoblasts, Nk cells, Kidney, Testes, Lung, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Non-Hodgkin Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Non-Hodgkin Lymphoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Non-Hodgkin Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.9MDM2, HPRT1, PRF1, BRAF, NBN
2MP:00053709.6BRAF, PRF1, HPRT1, BCL6, MDM2, LTA
3MP:00053979.3LTA, NBN, BRAF, PRF1, MS4A1, HPRT1
4MP:00053879.3NBN, BRAF, PRF1, MS4A1, HPRT1, BCL6
5MP:00028739.2BRAF, PRF1, HPRT1, BCL2L10, BCL6, RMRP

Publications for Non-Hodgkin Lymphoma

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Sources:
52PubMed
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Articles related to Non-Hodgkin Lymphoma:

(show top 50)    (show all 860)
idTitleAuthorsYear
1
Dietary patterns and the risk of non-Hodgkin lymphoma. (23659580)
2013
2
Primary non-Hodgkin lymphoma of the bladder. (24369199)
2013
3
Atrazine and nitrate in public drinking water supplies and non-hodgkin lymphoma in nebraska, USA. (23515852)
2013
4
Biodistribution and dosimetry of (177)Lu-tetulomab, a new radioimmunoconjugate for treatment of non-Hodgkin lymphoma. (23256748)
2013
5
External validation of a risk model of febrile neutropenia occurrence in patients with non-Hodgkin lymphoma. (23452152)
2013
6
Non-Hodgkin lymphoma as an uncommon cause of acute heart failure. (23503834)
2013
7
Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia. (24352795)
2013
8
90Yttrium-ibritumomab tiuxetan consolidation of first remission in advanced-stage follicular non-Hodgkin lymphoma: updated results after a median follow-up of 7.3 years from the International, Randomized, Phase III First-LineIndolent trial. (23547079)
2013
9
Long-Term Results of Autologous Hematopoietic Stem-Cell Transplantation After High-Dose 90Y-Ibritumomab Tiuxetan for Patients With Poor-Risk Non-Hodgkin Lymphoma Not Eligible for High-Dose BEAM. (23857974)
2013
10
Front-line immunochemotherapy for aggressive non-Hodgkin lymphoma using dose-dense rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone plus granulocyte-macrophage colony stimulating factor and pegfilgrastim as support. (22448918)
2012
11
Analysis of very elderly (a8Y80 years) non-hodgkin lymphoma: impact of functional status and co-morbidities on outcome. (22084970)
2012
12
The association of hepatitis B virus infection with B-cell non-Hodgkin lymphoma - a review. (22432084)
2012
13
Treatment option of bendamustine in combination with rituximab in elderly and frail patients with aggressive B-non-Hodgkin lymphoma: rational, efficacy, and tolerance. (22752146)
2012
14
Assessment of immunovirological features in HIV related non-Hodgkin lymphoma patients and their impact on outcome. (22244256)
2012
15
Cigarette smoking is associated with a small increase in the incidence of non-Hodgkin lymphoma: a meta-analysis of 24 observational studies. (22397720)
2012
16
Radiotherapy in stage I-III follicular non-Hodgkin lymphoma. Retrospective analysis of a series of 50 patients. (22349634)
2012
17
Long-term remission of paroxysmal nocturnal hemoglobinuria following chemoimmunotherapy for non-Hodgkin lymphoma. (22402359)
2012
18
Primary extra nodal non Hodgkin lymphoma: a 5 year retrospective analysis. (23244076)
2012
19
Results of the Japan Association of Childhood Leukemia Study (JACLS) NHL-98 protocol for the treatment of B-cell non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia in childhood. (21261497)
2011
20
Expression of serine 194-phosphorylated Fas-associated death domain protein correlates with proliferation in B-cell non-Hodgkin lymphomas. (21315423)
2011
21
Soluble IL-2RI+ facilitates IL-2-mediated immune responses and predicts reduced survival in follicular B-cell non-Hodgkin lymphoma. (21719603)
2011
22
Sexual well-being among survivors of non-Hodgkin lymphoma. (21875831)
2011
23
Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study. (20299965)
2010
24
KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma. (20519630)
2010
25
Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma. (19101572)
2009
26
Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. (19066394)
2009
27
Functional signatures identified in B-cell non-Hodgkin lymphoma profiles. (19863341)
2009
28
A 19-year follow-up of a patient with type 3 ectrodactyly-ectodermal dysplasia-clefting syndrome who developed non-Hodgkin lymphoma. (19716498)
2009
29
Interleukine-2 therapy does not increase the risk of Hodgkin or non-Hodgkin lymphoma in HIV-infected patients: results from FHDH ANRS CO4. (19131886)
2009
30
Non-Hodgkin lymphoma (NHL) in children with Nijmegen Breakage syndrome (NBS). (18937313)
2009
31
Fatal chylous ascites, pericarditis and extensive venous thrombosis, due to an aggressive T cell non-Hodgkin lymphoma. (18679682)
2009
32
Genetic variation in B-cell-activating factor is associated with an increased risk of developing B-cell non-Hodgkin lymphoma. (19383901)
2009
33
Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies. (19414860)
2009
34
The NF-kappaB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs. (18949621)
2008
35
Non-Hodgkin lymphoma related to hereditary nonpolyposis colorectal cancer in a patient with a novel heterozygous complex deletion in the MSH2 gene. (18181177)
2008
36
Soft tissue non-Hodgkin lymphoma of shoulder in a HIV patient: a report of a case and review of the literature. (18939988)
2008
37
Genetic polymorphisms in the proximal IL-10 promoter and susceptibility to non-Hodgkin lymphoma. (17990180)
2007
38
Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma. (16740140)
2006
39
Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut. (16738949)
2006
40
Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. (16857995)
2006
41
Inhibitory effect of triptolide on lymph node metastasis in patients with non-Hodgkin lymphoma by regulating SDF-1/CXCR4 axis in vitro. (17049119)
2006
42
A putative exonic splicing polymorphism in the BCL6 gene and the risk of non-Hodgkin lymphoma. (16264183)
2005
43
Alteration of SMRT tumor suppressor function in transformed non-Hodgkin lymphomas. (15930272)
2005
44
Intensive sequential chemotherapy with hematopoietic growth factor support for non-Hodgkin lymphoma in patients infected with the human immunodeficiency virus. (14770420)
2004
45
Expression profile and prognostic significance of CD24, p53 and p21 in lymphomas. A tissue microarray study of over 600 non-Hodgkin lymphomas]. (15455300)
2004
46
Genotyping of AR and PSA polymorphisms in a patient with Klinefelter syndrome, non-Hodgkin lymphoma, and adenocarcinoma of the prostate. (15350307)
2004
47
Therapy-related acute leukemia associated with involvement of 11q23 after high grade non-Hodgkin lymphoma. (9573684)
1998
48
Chemosensitive epidural spinal cord disease in non-Hodgkins lymphoma. (8649545)
1996
49
Immunohistochemistry of Hodgkin and non-Hodgkin lymphomas with emphasis on the diagnostic significance of the BNH9 antibody reactivity with anaplastic large cell (CD30 positive) lymphomas. (1330287)
1992
50
Familial non-Hodgkin lymphoma: histologic diversity and relation to other cancers. (276264)
1978

Variations for Non-Hodgkin Lymphoma

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Non-Hodgkin Lymphoma:

64
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly469AlaVAR_018620
2BRAFp.Gly469ArgVAR_018622
3BRAFp.Asp594GlyVAR_018624
4CASP10p.Ala414ValVAR_037430rs28936699

Clinvar genetic disease variations for Non-Hodgkin Lymphoma:

1 (show all 11)
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.974G> T (p.Gly325Val)single nucleotide variantPathogenic, Uncertain significancers121912659GRCh37Chr 17, 7576872: 7576872
2PRF1NM_001083116.1(PRF1): c.1122G> A (p.Trp374Ter)single nucleotide variantPathogenicrs104894176GRCh37Chr 10, 72358355: 72358355
3PRF1NM_001083116.1(PRF1): c.755A> G (p.Asn252Ser)single nucleotide variantPathogenicrs28933375GRCh37Chr 10, 72358722: 72358722
4BRAFNM_004333.4(BRAF): c.1405G> C (p.Gly469Arg)single nucleotide variantPathogenicrs121913357GRCh37Chr 7, 140481403: 140481403
5BRAFNM_004333.4(BRAF): c.1406G> C (p.Gly469Ala)single nucleotide variantPathogenicrs121913355GRCh37Chr 7, 140481402: 140481402
6BRAFNM_004333.4(BRAF): c.1781A> G (p.Asp594Gly)single nucleotide variantPathogenicrs121913338GRCh37Chr 7, 140453154: 140453154
7RAD54BNM_012415.3(RAD54B): c.1778A> G (p.Asn593Ser)single nucleotide variantPathogenicrs114216685GRCh37Chr 8, 95403868: 95403868
8RAD54LNM_001142548.1(RAD54L): c.1331T> A (p.Val444Glu)single nucleotide variantPathogenicrs121908689GRCh37Chr 1, 46738430: 46738430
9CASP10NM_032977.3(CASP10): c.1241C> T (p.Ala414Val)single nucleotide variantPathogenicrs28936699GRCh37Chr 2, 202074111: 202074111
10CASP10NM_032977.3(CASP10): c.769C> T (p.Gln257Ter)single nucleotide variantPathogenicrs121909775GRCh37Chr 2, 202070652: 202070652
11CASP10NM_032977.3(CASP10): c.1042_1043insA (p.Gly348Glufs)insertionPathogenicrs398122800GRCh37Chr 2, 202073912: 202073913

Expression for genes affiliated with Non-Hodgkin Lymphoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Non-Hodgkin Lymphoma

Search GEO for disease gene expression data for Non-Hodgkin Lymphoma.

Pathways for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 12EMD Millipore, 54R&D Systems, 53QIAGEN, 55Reactome
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Pathways related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CASP10, BCL6, MDM2
2
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
10.1BCL6, MDM2, BRAF
3
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
10.0IGH, IGK, MDM2
4
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.8BCL6, BRAF, IGK, IGH
5
Show member pathways
9.8MDM2, LTA, CASP10, CSF3, BRAF
6
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.8LTA, MDM2, CASP10, BCL2L10, PRF1
7
Show member pathways
Immune response CD16 signaling in NK cells60
9.7KIR2DL5A, PRF1, BRAF, IGK, IGH

Compounds for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1methylmethanesulfonate4510.4NBN, HPRT1, MDM2
2mycophenolate mofetil45 51 1112.3LTA, CSF3, HPRT1
3fludarabine45 51 1112.3MDM2, CSF3, MS4A1
4amifostine45 1111.3HPRT1, CSF3
5irinotecan45 51 1112.3BRAF, CSF3, MDM2
6bpde4510.3MDM2, HPRT1
7mitomycin c4510.3NBN, HPRT1, CSF3, MDM2
8hydroxyurea45 51 1112.3NBN, HPRT1, CSF3
9rituximab45 51 1112.3CSF3, BCL6, MS4A1
10valine4510.3MDM2, CSF3, HPRT1, BRAF
11imatinib45 51 1112.2BRAF, BCL6, CSF3, MDM2
12etoposide45 51 61 1113.2NBN, HPRT1, CSF3, MDM2
13paclitaxel45 51 1112.2MDM2, CASP10, CSF3, BRAF
14vincristine45 51 1112.2MDM2, CSF3, BCL6
156 mercaptopurine4510.2HPRT1, CSF3
16adriamycin4510.2MDM2, CSF3, HPRT1
17paraffin4510.1BRAF, MS4A1, BCL6, MDM2, LTA
18o6-methylguanine4510.1HPRT1, BRAF
19doxorubicin45 51 1112.1NBN, BCL6, CSF3, MDM2
20cycloheximide4510.0PRF1, BCL6, CSF3, MDM2, LTA
21cisplatin45 51 61 1113.0BRAF, HPRT1, CSF3, CASP10, GSTM3, MDM2
22cyclophosphamide45 51 1112.0MDM2, GSTM3, CSF3, BCL6, HPRT1, MS4A1
23enterotoxin459.9LTA, PRF1
24serine459.8NBN, BRAF, PRF1, HPRT1, BCL6, CASP10
25tyrosine459.6BCL6, CSF3, KIR2DL5A, MDM2, LTA, BRAF

GO Terms for genes affiliated with Non-Hodgkin Lymphoma

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16Gene Ontology
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Cellular components related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.2BCL6, NBN

Biological processes related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytolysisGO:01983510.2HPRT1, PRF1

Products for genes affiliated with Non-Hodgkin Lymphoma

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Non-Hodgkin Lymphoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet