MCID: NNH001
MIFTS: 72

Non-Hodgkin Lymphoma malady

Cancer diseases, Immune diseases categories

Summaries for Non-Hodgkin Lymphoma

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46OMIM, 32MalaCards
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MalaCards: Non-Hodgkin Lymphoma, also known as lymphoma, non-hodgkin, is related to leukemia and hepatitis. An important gene associated with Non-Hodgkin Lymphoma is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The drugs mercaptopurine and carmustine and the compounds paraffin and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Description from OMIM:46 605027

Aliases & Classifications for Non-Hodgkin Lymphoma

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Sources:
8Disease Ontology, 30LifeMap Discovery™, 9diseasecard, 46OMIM, 60UMLS, 44Novoseek, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

non-hodgkin lymphoma 8 30
lymphoma, non-hodgkin 9 46 60
lymphoma non-hodgkins 44


External Ids:

Disease Ontology8 DOID:0060060
OMIM46 605027
ICD1025 C85.7

Related Diseases for Non-Hodgkin Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Non-Hodgkin Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.4CASP10, CSF3, MDM2, LTA, NBN, BCL6
2hepatitis31.1LTA
3chronic lymphocytic leukemia31.1CASP10, MDM2, LTA, MS4A1, BCL6, BCL2
4acute leukemia31.0CSF3
5mantle cell lymphoma30.9MDM2, BCL6, BCL2
6myeloma30.8CSF3, LTA, BCL6, BCL2
7multiple myeloma30.7CSF3
8sarcoma30.6MDM2, BRAF
9neutropenia30.6CSF3
10pneumonia30.6PRF1, CSF3
11burkitt's lymphoma30.6BCL2, BCL6, MS4A1, MDM2
12anaplastic large cell lymphoma30.5BCL6, TNFSF8
13breast cancer30.4BRAF, CASP10, CSF3, MDM2, SHMT1, NBN
14adenocarcinoma30.4BRAF, CT49, MDM2, BCL2
15myeloid leukemia30.4BCL2, LTA, CSF3
16familial non-hodgkin lymphoma30.3CASP10, BRAF
17ataxia telangiectasia30.3MDM2, NBN
18colorectal cancer30.3BCL2, NBN, MDM2, BRAF
19central nervous system lymphoma30.3BCL6
20hodgkin's lymphoma30.1CSF3, TNFSF8, MDM2, LTA, MS4A1, BCL6
21melanoma30.1BRAF, CASP10, CT49, MDM2, PRF1, NBN
22lymphoma, diffuse large cell30.1MS4A1, BCL6, BCL2
23lung cancer30.1CSF3, BCL2
24bladder carcinoma30.1MDM2, LTA
25arthritis30.1LTA
26basal cell carcinoma30.1GSTM3, BCL2, LTA
27liposarcoma30.1MDM2
28rhabdomyosarcoma30.1MDM2
29malignant mesothelioma30.1CT49
30hepatitis c10.6
31hepatitis b10.6
32adult lymphoma10.6
33diffuse large b-cell lymphoma10.6
34bone lymphoma10.6
35pediatric lymphoma10.6
36hepatitis a10.6
37breast lymphoma10.5
38lymphoblastic leukemia10.5
39cryoglobulinemia10.4
40obstructive jaundice10.4
41gastric lymphoma10.4
42acquired immunodeficiency syndrome10.4
43orbit lymphoma10.4
44autoimmune hemolytic anemia10.4
45childhood leukemia10.4
46hemolytic anemia10.4
47liver lymphoma10.3
48heart lymphoma10.3
49ovarian lymphoma10.3
50progressive multifocal leukoencephalopathy10.3

Graphical network of the top 20 diseases related to Non-Hodgkin Lymphoma:



Diseases related to non-hodgkin lymphoma

Clinical Features for Non-Hodgkin Lymphoma

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Sources:
46OMIM
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Clinical features from OMIM:

605027

Drugs & Therapeutics for Non-Hodgkin Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Non-Hodgkin Lymphoma

Drug clinical trials:

Search ClinicalTrials for Non-Hodgkin Lymphoma

Search NIH Clinical Center for Non-Hodgkin Lymphoma

Search CenterWatch for Non-Hodgkin Lymphoma

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Non-Hodgkin Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Non-Hodgkin Lymphoma

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Anatomical Context for Non-Hodgkin Lymphoma

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Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Non-Hodgkin Lymphoma:

32
B cells, T cells, Bone, Bone marrow, Breast, Myeloid, Endothelial, Prostate, Skin, Monocytes, Liver, Heart, Spinal cord, Brain, Thyroid, B lymphoblasts, Nk cells, Tongue, Cervix, Testes, Ovary, Lung, Kidney, Lymph node, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Non-Hodgkin Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Non-Hodgkin Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Non-Hodgkin Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.2BCL2, BRAF, CSF3, TNFSF8, MDM2, RHOH
2MP:000539712.0RHOH, MDM2, CSF3, BRAF, PRF1, LTA
3MP:000538411.8MDM2, RHOH, PRF1, LTA, MS4A1, NBN
4MP:000537011.1BRAF, MDM2, PRF1, SHMT1, LTA, BCL6
5MP:000200610.8BRAF, MDM2, SHMT1

Publications for Non-Hodgkin Lymphoma

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Sources:
50PubMed
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Articles related to Non-Hodgkin Lymphoma:

(show top 50)    (show all 908)
idTitleAuthorsYear
1
High dose chemotherapy with autologous stem cell transplantation for patients with transformed B-cell non-Hodgkin lymphoma in the rituximab era. (24432894)
2014
2
Primary SjAPgren's syndrome and B-non-Hodgkin lymphoma: role of CD4+ T lymphocytopenia. (22886469)
2013
3
Somatic mutation of H3F3A, a chromatin remodeling gene, is rare in acute leukemias and non-Hodgkin lymphoma. (23116151)
2013
4
Orbital involvement by non-Hodgkin lymphoma NK T cells. (24332692)
2013
5
Early Determination of Prognosis by Interim 3'-Deoxy-3'-18F-Fluorothymidine PET in Patients with Non-Hodgkin Lymphoma. (24365650)
2013
6
Genetic Variations of Tumor Necrosis Factor -I+-308 and Lymphtoxin-I++252 in Non-Hodgkin Lymphoma and Acute Lymphoblastic Leukemia Patients. (24171078)
2013
7
Non-hodgkin B-cell lymphoma of the ovary in a child with Ataxia-telangiectasia. (23312583)
2013
8
Abdominal aortic aneurysm with bony erosion mimicking recurrent non-Hodgkin lymphoma on FDG PET/CT. (23143046)
2013
9
Occupational exposure to trichloroethylene and risk of non-Hodgkin lymphoma and its major subtypes: a pooled IinterLlymph analysis. (23881218)
2013
10
Characterization of insulin resistance in young adult survivors of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma. (22967316)
2013
11
Efficacy of pamidronate in children with low bone mineral density during and after chemotherapy for acute lymphoblastic leukemia and non-Hodgkin lymphoma. (23826578)
2013
12
Dietary intake of fruits and vegetables and overall survival in non-Hodgkin lymphoma. (23488609)
2013
13
Sex- and subtype-specific analysis of H2AFX polymorphisms in non-Hodgkin lymphoma. (24069324)
2013
14
Microvascular density in non-Hodgkin B-cell lymphomas measured using digital morphometry. (22395502)
2012
15
Socioeconomic position, treatment, and survival of non-Hodgkin lymphoma in Denmark--a nationwide study. (22315055)
2012
16
Spatial-temporal analysis of non-Hodgkin lymphoma risk using multiple residential locations. (22682442)
2012
17
Liver cancer and non-Hodgkin lymphoma in hepatitis C virus-infected patients: results from the DANVIR cohort study. (21780099)
2012
18
Association between polymorphic sites in thymidylate synthase gene and risk of non-Hodgkin lymphoma: a systematic review and pooled analysis. (22397721)
2012
19
Pediatric nonlymphoblastic non-Hodgkin lymphoma: baseline, interim, and posttreatment PET/CT versus contrast-enhanced CT for evaluation--a prospective study. (22357895)
2012
20
Plasma cytokine profiles at diagnosis in pediatric patients with non-hodgkin lymphoma. (22430582)
2012
21
Dose-escalated radioimmunotherapy as part of reduced intensity conditioning for allogeneic transplantation in patients with advanced high-grade non-Hodgkin lymphoma. (22504934)
2012
22
A Canadian perspective on bendamustine for the treatment of chronic lymphocytic leukemia and non-Hodgkin lymphoma. (22670095)
2012
23
Strongyloides stercoralis induced bilateral blood stained pleural effusion in patient with recurrent Non-Hodgkin lymphoma. (21602770)
2011
24
Ribosomal protein S6 is highly expressed in non-Hodgkin lymphoma and associates with mRNA containing a 5' terminal oligopyrimidine tract. (21102526)
2011
25
HMG-CoA reductase inhibitors (statins) use and risk of non-Hodgkin lymphoma in HIV-positive persons. (21681055)
2011
26
Clinical prognostic factors of diffuse large B cell non-Hodgkin lymphoma: a retrospective study. (22099932)
2011
27
Exposure to multiple pesticides and risk of non-Hodgkin lymphoma in men from six Canadian provinces. (21776232)
2011
28
Genetic polymorphisms of tumor necrosis factor-I+ and lymphotoxin-I+ in Chinese patients with non-Hodgkin lymphoma. (20957367)
2011
29
Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of non-Hodgkin lymphoma. (20131310)
2010
30
Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium. (20047977)
2010
31
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma. (19391036)
2009
32
A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma. (19029192)
2009
33
Activated T-cell-mediated immunotherapy with a chimeric receptor against CD38 in B-cell non-Hodgkin lymphoma. (19561535)
2009
34
Nephrotic syndrome and acute renal failure in non-Hodgkin lymphoplasmacytic lymphoma. (18214715)
2008
35
FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. (17895404)
2008
36
Genetic variation in H2AFX contributes to risk of non-Hodgkin lymphoma. (17548670)
2007
37
Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma. (16740140)
2006
38
Small B cell Non-Hodgkins Lymphoma in Pakistan. (16454131)
2006
39
Use of nonsteroidal antiinflammatory drugs and non-Hodgkin lymphoma: a population-based case-control study. (16840523)
2006
40
Prior medical conditions and medication use and risk of non-Hodgkin lymphoma in Connecticut United States women. (15141141)
2004
41
Epstein-Barr virus-associated B-cell non-Hodgkin lymphoma following treatment of hairy cell leukemia with cladribine. (14568909)
2003
42
Hidden gene amplifications in aggressive B-cell non-Hodgkin lymphomas detected by microarray-based comparative genomic hybridization. (12618769)
2003
43
Phase 1 study of interleukin-12 in combination with rituximab in patients with B-cell non-Hodgkin lymphoma. (11756154)
2002
44
Epstein-Barr virus-negative boys with non-Hodgkin lymphoma are mutated in the SH2D1A gene, as are patients with X-linked lymphoproliferative disease (XLP). (10556288)
1999
45
Therapy-related acute leukemia associated with involvement of 11q23 after high grade non-Hodgkin lymphoma. (9573684)
1998
46
Thiorphan stimulates clonal growth of GM-CFU in short-term cultures of bone marrow from a healthy donor and from patients with non-Hodgkin lymphoma. (9856287)
1998
47
Deregulation of BCL6 in non-Hodgkin lymphoma by insertion of IGH sequences in complex translocations involving band 3q27. (9824206)
1998
48
Differential expression of very late activation antigen-3 (VLA-3)/VLA-4 in B-cell non-Hodgkin lymphoma and B-cell chronic lymphocytic leukemia. (1586717)
1992
49
Follicular dendritic cells in non-Hodgkin-lymphoma express adhesion molecules complementary to ligands on neoplastic B-cells. (1482656)
1992
50
Myopathic carnitine deficiency associated with lymphocytic malignant non-Hodgkin lymphoma and monoclonal immunoglobulin G-K. (6471781)
1984

Genetic Variations for Non-Hodgkin Lymphoma

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Non-Hodgkin Lymphoma:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly469AlaVAR_018620
2BRAFp.Gly469ArgVAR_018622
3BRAFp.Asp594GlyVAR_018624
4CASP10p.Ala414ValVAR_037430rs28936699

Expression for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Non-Hodgkin Lymphoma

Search GEO for disease gene expression data for Non-Hodgkin Lymphoma.

Pathways for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 55SinoBiological, 52R&D Systems, 12EMD Millipore
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Pathways related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5BRAF, CASP10, CSF3, TNFSF8, MDM2, LTA
2
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11.4BRAF, CASP10, CSF3, TNFSF8, LTA, BCL2
3
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11.2BCL2, LTA, PRF1, MDM2, CASP10
4
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11.2BCL2, LTA, MDM2, CASP10, BRAF
5
Hide members
11.2CASP10, CSF3, TNFSF8, LTA, BCL2
6
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11.2CSF3, TNFSF8, MDM2, LTA, BCL2
7
Hide members
11.1BCL2, LTA, TNFSF8, CASP10
811.1CASP10, MDM2, BCL6, BCL2
9
Apoptosis and survival Caspase cascade
Hide members
10.9BCL2, PRF1, CASP10
10
Hide members
10.9BCL2, LTA, PRF1
11
Hide members
10.9CASP10, MDM2, BCL2
1210.9BRAF, MDM2, BCL2
13
Hide members
10.9BCL2, MDM2, BRAF
1410.9CASP10, BCL6, BCL2

Compounds for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1paraffin4411.9BRAF, CT49, MDM2, LTA, MS4A1, BCL6
2cyclophosphamide44 49 1113.7GSTM3, BCL2, BCL6, MS4A1, MDM2, CSF3
3cisplatin44 49 59 1114.7BRAF, CASP10, CSF3, MDM2, BCL2, GSTM3
4vegf4411.7BRAF, CSF3, CT49, MDM2, LTA, BCL2
5imatinib44 49 1113.6BRAF, CSF3, MDM2, BCL6, BCL2
6doxorubicin44 49 1113.5CSF3, MDM2, NBN, BCL6, BCL2
7serine4411.4CASP10, CT49, LTA, NBN
8retinoic acid44 2412.4BRAF, CSF3, CT49, LTA, BCL6, BCL2
9fludarabine44 1112.4BCL2, MS4A1, MDM2, CSF3
10rituximab44 49 1113.4CSF3, MS4A1, BCL6, BCL2
11mitomycin c4411.4CSF3, MDM2, NBN, BCL2
12vincristine44 49 1113.4CSF3, MDM2, BCL6, BCL2
13paclitaxel44 49 1113.4BRAF, CSF3, MDM2, BCL2
14agar4411.3PRF1, MDM2, CT49, BRAF
15etoposide44 49 59 1114.3BCL2, NBN, MDM2, CSF3
162-chlorodeoxyadenosine4411.2BCL2, MDM2, CSF3
17progesterone44 59 28 11 2415.2BRAF, CT49, MDM2, LTA, BCL2
18oligonucleotide4411.2BCL2, LTA, MDM2, CT49, BRAF
19daunorubicin44 49 1113.2CSF3, MDM2, BCL2
20irinotecan44 49 1113.1BRAF, CSF3, MDM2
21carboplatin44 49 1113.1BCL2, MDM2, CSF3
22rapamycin4411.0BCL2, NBN, MDM2, BRAF
23cycloheximide4411.0LTA
2410-hydroxycamptothecin4410.9BCL2, MDM2
25vinblastine44 49 1112.9MDM2
26estrogen4410.8BCL6
27thymidylate4410.6MDM2, SHMT1, BCL2

GO Terms for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
16Gene Ontology
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Cellular components related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.8BCL6, NBN

Biological processes related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:00691511.3BCL2, CASP10, TNFSF8, PRF1, LTA, NBN
2response to iron ionGO:01003910.8BCL2, MDM2
3positive regulation of peptidyl-serine phosphorylationGO:03313810.6BCL2, CSF3, BRAF

Products for genes affiliated with Non-Hodgkin Lymphoma

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  • Antibodies
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Sources for Non-Hodgkin Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet