MCID: NNH001
MIFTS: 58

Non-Hodgkin Lymphoma malady

Cancer, Immune categories

Summaries for Non-Hodgkin Lymphoma

Sources:
47OMIM, 33MalaCards
See all sources

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MalaCards: Non-Hodgkin Lymphoma, also known as lymphoma, non-hodgkin, is related to follicular lymphoma and lymphoma, diffuse large cell. An important gene associated with Non-Hodgkin Lymphoma is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The drugs cisplatin and cisplatin pwdr and the compounds paraffin and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, t cells and b cells, and related mouse phenotypes are immune system and hematopoietic system.

Description from OMIM:47 605027

Aliases & Classifications for Non-Hodgkin Lymphoma

Sources:
8Disease Ontology, 31LifeMap Discovery™, 9diseasecard, 47OMIM, 61UMLS, 45Novoseek, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Immune


Aliases & Descriptions:

non-hodgkin lymphoma 8 31
lymphoma, non-hodgkin 9 47 61
lymphoma non-hodgkins 45


External Ids:

Disease Ontology8 DOID:0060060
OMIM47 605027
ICD1025 C85.7

Related Diseases for Non-Hodgkin Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Non-Hodgkin Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1follicular lymphoma31.2BCL2, BCL6, MS4A1
2lymphoma, diffuse large cell31.0MS4A1, BCL6, BCL2
3acute leukemia31.0CSF3
4mantle cell lymphoma31.0MDM2, BCL6, BCL2
5peripheral t-cell lymphoma30.8BCL6, MS4A1, LTA
6burkitt's lymphoma30.6BCL2, BCL6, MS4A1, MDM2
7b-cell lymphomas30.5CT49, MDM2, PRF1, MS4A1, NBN, BCL6
8anaplastic large cell lymphoma30.5BCL6, TNFSF8
9adenocarcinoma30.4BRAF, CT49, MDM2, BCL2
10familial non-hodgkin lymphoma30.4CASP10, BRAF
11ataxia telangiectasia30.4MDM2, NBN
12colorectal cancer30.4BCL2, NBN, MDM2, BRAF
13central nervous system lymphoma30.4BCL6
14bladder carcinoma30.1MDM2, LTA
15oral cancer30.1GSTM3, MDM2
16arthritis30.1LTA
17basal cell carcinoma30.1GSTM3, BCL2, LTA
18hodgkin lymphoma, childhood10.7
19hepatitis c10.7
20adult lymphoma10.7
21lymphoblastic lymphoma10.7
22bone lymphoma10.6
23pediatric lymphoma10.6
24colon lymphoma10.6
25t-cell leukemia10.6
26leukemia/lymphoma, t-cell10.6
27breast lymphoma10.5
28hepatitis c virus10.5
29hepatitis a10.5
30hematopoietic stem cell transplantation10.5
31kaposi's sarcoma10.5
32indolent b cell lymphoma10.5
33cryoglobulinemia10.4
34obstructive jaundice10.4
35gastric lymphoma10.4
36acquired immunodeficiency syndrome10.4
37orbit lymphoma10.4
38autoimmune hemolytic anemia10.4
39hepatitis d10.4
40leukemia, t-cell, chronic10.4
41liver lymphoma10.3
42heart lymphoma10.3
43ovarian lymphoma10.3
44progressive multifocal leukoencephalopathy10.3
45prostate lymphoma10.3
46diffuse large b-cell lymphoma10.3
47n syndrome10.3
48lymphoid leukemia10.3
49thyroid lymphoma10.3
50wiskott-aldrich syndrome10.3

Graphical network of the top 20 diseases related to Non-Hodgkin Lymphoma:



Diseases related to non-hodgkin lymphoma

Clinical Features for Non-Hodgkin Lymphoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

605027

Drugs & Therapeutics for Non-Hodgkin Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Non-Hodgkin Lymphoma

Drug clinical trials:

Search ClinicalTrials for Non-Hodgkin Lymphoma

Search NIH Clinical Center for Non-Hodgkin Lymphoma

Search CenterWatch for Non-Hodgkin Lymphoma

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Non-Hodgkin Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Non-Hodgkin Lymphoma

Anatomical Context for Non-Hodgkin Lymphoma

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Non-Hodgkin Lymphoma:

33
Bone marrow, T cells, B cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Non-Hodgkin Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Non-Hodgkin Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Non-Hodgkin Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.2BCL2, BRAF, CSF3, TNFSF8, MDM2, RHOH
2MP:000539712.0RHOH, MDM2, CSF3, BRAF, PRF1, LTA
3MP:000538411.8MDM2, RHOH, PRF1, LTA, MS4A1, NBN
4MP:000537011.1BRAF, MDM2, PRF1, SHMT1, LTA, BCL6
5MP:000200610.8BRAF, MDM2, SHMT1

Publications for Non-Hodgkin Lymphoma

Sources:
51PubMed
See all sources

Articles related to Non-Hodgkin Lymphoma:

(show all 18)
idTitleAuthorsYear
1
Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in non-Hodgkin lymphoma and significant correlations with lactic acid dehydrogenase and I^2-microglobulin. (23859015)
2013
2
Aspirin and other nonsteroidal anti-inflammatory drugs and risk of non-hodgkin lymphoma. (23329726)
2013
3
CD80 (B7.1) is expressed on both malignant B cells and nonmalignant stromal cells in non-Hodgkin lymphoma. (22076940)
2012
4
Pediatric nonlymphoblastic non-Hodgkin lymphoma: baseline, interim, and posttreatment PET/CT versus contrast-enhanced CT for evaluation--a prospective study. (22357895)
2012
5
Nonmyeloablative allogeneic stem cell transplantation for non-hodgkin lymphoma. (23006952)
2012
6
Nonbacterial thrombotic endocarditis in a child with non-Hodgkin's lymphoma. (22327229)
2012
7
Non-Hodgkin lymphoma related to hereditary nonpolyposis colorectal cancer in a patient with a novel heterozygous complex deletion in the MSH2 gene. (18181177)
2008
8
Use of nonsteroidal antiinflammatory drugs and non-Hodgkin lymphoma: a population-based case-control study. (16840523)
2006
9
Phase I/II trial of nonpegylated liposomal doxorubicin, cyclophosphamide, vincristine, and prednisone in the treatment of newly diagnosed aggressive non-Hodgkin's lymphoma. (16879771)
2006
10
Study of mutations in 5'-noncoding region of BCL-6 gene in B-cell non-Hodgkin's lymphomas]. (15256116)
2004
11
Nonmyeloablative allogeneic stem cell transplantation for refractory Hodgkin's lymphoma complicated by interleukin-2 responsive progressive multifocal leukoencephalopathy. (12185517)
2002
12
Unusual case presentation of lichen simplex chronicus, Hodgkin's lymphoma, and nonpuerperal hyperprolactinemia-galactorrhea. (11585377)
2001
13
Mobilized human CD34+ hematopoietic stem cells enhance tumor growth in a nonobese diabetic/severe combined immunodeficient mouse model of human non-Hodgkin's lymphoma. (11606408)
2001
14
Alterations on the 5' noncoding region of the BCL-6 gene are not correlated with BCL-6 protein expression in T cell non-Hodgkin lymphomas. (11742039)
2001
15
A phase II multicenter study of CAMPATH-1H antibody in previously treated patients with nonbulky non-Hodgkin's lymphoma. (11342359)
2001
16
Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma. (10803463)
2000
17
Mutation analysis of the 5' noncoding regulatory region of the BCL-6 gene in non-Hodgkin lymphoma: evidence for recurrent mutations and intraclonal heterogeneity. (10666217)
2000
18
Frequent mutation of the 5' noncoding region of the BCL-6 gene in acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas. (9160681)
1997

Genetic Variations for Non-Hodgkin Lymphoma

Expression for genes affiliated with Non-Hodgkin Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Non-Hodgkin Lymphoma

Search GEO for disease gene expression data for Non-Hodgkin Lymphoma.

Pathways for genes affiliated with Non-Hodgkin Lymphoma

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 56SinoBiological, 53R&D Systems, 12EMD Millipore
See all sources

Pathways related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5BRAF, CASP10, CSF3, TNFSF8, MDM2, LTA
2
Hide members
11.4BRAF, CASP10, CSF3, TNFSF8, LTA, BCL2
3
Hide members
11.2BCL2, LTA, PRF1, MDM2, CASP10
4
Hide members
11.2BCL2, LTA, MDM2, CASP10, BRAF
5
Hide members
11.2CASP10, CSF3, TNFSF8, LTA, BCL2
6
Hide members
11.2CSF3, TNFSF8, MDM2, LTA, BCL2
7
Hide members
11.1BCL2, LTA, TNFSF8, CASP10
811.1CASP10, MDM2, BCL6, BCL2
9
Apoptosis and survival Caspase cascade
Hide members
10.9BCL2, PRF1, CASP10
10
Hide members
10.9BCL2, LTA, PRF1
11
Hide members
10.9CASP10, MDM2, BCL2
1210.9BRAF, MDM2, BCL2
13
Hide members
10.9BCL2, MDM2, BRAF
1410.9CASP10, BCL6, BCL2

Compounds for genes affiliated with Non-Hodgkin Lymphoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 29IUPHAR
See all sources

Compounds related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1paraffin4511.9BRAF, CT49, MDM2, LTA, MS4A1, BCL6
2cyclophosphamide45 50 1113.7GSTM3, BCL2, BCL6, MS4A1, MDM2, CSF3
3cisplatin45 50 60 1114.7BRAF, CASP10, CSF3, MDM2, BCL2, GSTM3
4vegf4511.7BRAF, CSF3, CT49, MDM2, LTA, BCL2
5imatinib45 50 1113.6BRAF, CSF3, MDM2, BCL6, BCL2
6doxorubicin45 50 1113.5CSF3, MDM2, NBN, BCL6, BCL2
7serine4511.4CASP10, CT49, LTA, NBN
8retinoic acid45 2412.4BRAF, CSF3, CT49, LTA, BCL6, BCL2
9fludarabine45 1112.4BCL2, MS4A1, MDM2, CSF3
10rituximab45 50 1113.4CSF3, MS4A1, BCL6, BCL2
11mitomycin c4511.4CSF3, MDM2, NBN, BCL2
12vincristine45 50 1113.4CSF3, MDM2, BCL6, BCL2
13paclitaxel45 50 1113.4BRAF, CSF3, MDM2, BCL2
14agar4511.3PRF1, MDM2, CT49, BRAF
15etoposide45 50 60 1114.3BCL2, NBN, MDM2, CSF3
162-chlorodeoxyadenosine4511.2BCL2, MDM2, CSF3
17progesterone45 60 29 11 2415.2BRAF, CT49, MDM2, LTA, BCL2
18oligonucleotide4511.2BCL2, LTA, MDM2, CT49, BRAF
19daunorubicin45 50 1113.2CSF3, MDM2, BCL2
20irinotecan45 50 1113.1BRAF, CSF3, MDM2
21carboplatin45 50 1113.1BCL2, MDM2, CSF3
22rapamycin4511.0BCL2, NBN, MDM2, BRAF
23cycloheximide4511.0LTA
2410-hydroxycamptothecin4510.9BCL2, MDM2
25vinblastine45 50 1112.9MDM2
26estrogen4510.8BCL6
27thymidylate4510.6MDM2, SHMT1, BCL2

GO Terms for genes affiliated with Non-Hodgkin Lymphoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.8BCL6, NBN

Biological processes related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:00691511.3BCL2, CASP10, TNFSF8, PRF1, LTA, NBN
2response to iron ionGO:01003910.8BCL2, MDM2
3positive regulation of peptidyl-serine phosphorylationGO:03313810.6BCL2, CSF3, BRAF

Products for genes affiliated with Non-Hodgkin Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Non-Hodgkin Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet