MCID: NNH001
MIFTS: 72

Non-Hodgkin Lymphoma malady

Cancer diseases, Immune diseases categories

Summaries for Non-Hodgkin Lymphoma

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46OMIM, 32MalaCards
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MalaCards: Non-Hodgkin Lymphoma, also known as lymphoma, non-hodgkin, is related to leukemia and hepatitis. An important gene associated with Non-Hodgkin Lymphoma is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The drugs mercaptopurine and carmustine and the compounds paraffin and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Description from OMIM:46 605027

Aliases & Classifications for Non-Hodgkin Lymphoma

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Sources:
8Disease Ontology, 30LifeMap Discovery™, 9diseasecard, 46OMIM, 60UMLS, 44Novoseek, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

non-hodgkin lymphoma 8 30
lymphoma, non-hodgkin 9 46 60
lymphoma non-hodgkins 44


External Ids:

Disease Ontology8 DOID:0060060
OMIM46 605027
ICD1025 C85.7

Related Diseases for Non-Hodgkin Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Non-Hodgkin Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.4CASP10, CSF3, MDM2, LTA, NBN, BCL6
2hepatitis31.1LTA
3chronic lymphocytic leukemia31.1CASP10, MDM2, LTA, MS4A1, BCL6, BCL2
4acute leukemia31.0CSF3
5mantle cell lymphoma30.9MDM2, BCL6, BCL2
6myeloma30.8CSF3, LTA, BCL6, BCL2
7multiple myeloma30.7CSF3
8sarcoma30.6MDM2, BRAF
9neutropenia30.6CSF3
10pneumonia30.6PRF1, CSF3
11burkitt's lymphoma30.6BCL2, BCL6, MS4A1, MDM2
12anaplastic large cell lymphoma30.5BCL6, TNFSF8
13breast cancer30.4BRAF, CASP10, CSF3, MDM2, SHMT1, NBN
14adenocarcinoma30.4BRAF, CT49, MDM2, BCL2
15myeloid leukemia30.4BCL2, LTA, CSF3
16familial non-hodgkin lymphoma30.3CASP10, BRAF
17ataxia telangiectasia30.3MDM2, NBN
18colorectal cancer30.3BCL2, NBN, MDM2, BRAF
19central nervous system lymphoma30.3BCL6
20hodgkin's lymphoma30.1CSF3, TNFSF8, MDM2, LTA, MS4A1, BCL6
21melanoma30.1BRAF, CASP10, CT49, MDM2, PRF1, NBN
22lymphoma, diffuse large cell30.1MS4A1, BCL6, BCL2
23lung cancer30.1CSF3, BCL2
24bladder carcinoma30.1MDM2, LTA
25arthritis30.1LTA
26basal cell carcinoma30.1GSTM3, BCL2, LTA
27liposarcoma30.1MDM2
28rhabdomyosarcoma30.1MDM2
29malignant mesothelioma30.1CT49
30hepatitis c10.6
31hepatitis b10.6
32adult lymphoma10.6
33diffuse large b-cell lymphoma10.6
34bone lymphoma10.6
35pediatric lymphoma10.6
36hepatitis a10.6
37breast lymphoma10.5
38lymphoblastic leukemia10.5
39cryoglobulinemia10.4
40obstructive jaundice10.4
41gastric lymphoma10.4
42acquired immunodeficiency syndrome10.4
43orbit lymphoma10.4
44autoimmune hemolytic anemia10.4
45childhood leukemia10.4
46hemolytic anemia10.4
47liver lymphoma10.3
48heart lymphoma10.3
49ovarian lymphoma10.3
50progressive multifocal leukoencephalopathy10.3

Graphical network of the top 20 diseases related to Non-Hodgkin Lymphoma:



Diseases related to non-hodgkin lymphoma

Clinical Features for Non-Hodgkin Lymphoma

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Sources:
46OMIM
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Clinical features from OMIM:

605027

Drugs & Therapeutics for Non-Hodgkin Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Non-Hodgkin Lymphoma

Drug clinical trials:

Search ClinicalTrials for Non-Hodgkin Lymphoma

Search NIH Clinical Center for Non-Hodgkin Lymphoma

Search CenterWatch for Non-Hodgkin Lymphoma

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Non-Hodgkin Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Non-Hodgkin Lymphoma

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Anatomical Context for Non-Hodgkin Lymphoma

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Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Non-Hodgkin Lymphoma:

32
B cells, T cells, Bone, Bone marrow, Breast, Myeloid, Endothelial, Prostate, Skin, Monocytes, Liver, Heart, Spinal cord, Brain, Thyroid, B lymphoblasts, Nk cells, Tongue, Cervix, Testes, Ovary, Lung, Kidney, Lymph node, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Non-Hodgkin Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Non-Hodgkin Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Non-Hodgkin Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.2BCL2, BRAF, CSF3, TNFSF8, MDM2, RHOH
2MP:000539712.0RHOH, MDM2, CSF3, BRAF, PRF1, LTA
3MP:000538411.8MDM2, RHOH, PRF1, LTA, MS4A1, NBN
4MP:000537011.1BRAF, MDM2, PRF1, SHMT1, LTA, BCL6
5MP:000200610.8BRAF, MDM2, SHMT1

Publications for Non-Hodgkin Lymphoma

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Sources:
50PubMed
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Articles related to Non-Hodgkin Lymphoma:

(show top 50)    (show all 908)
idTitleAuthorsYear
1
Primary non-Hodgkin lymphoma in the pterygopalatine fossa. A peculiar diagnosis with a minimally invasive endoscopic approach. (23743538)
2014
2
Anemia in diffuse large B-cell non-Hodgkin lymphoma: the role of interleukin-6, hepcidin and erythropoietin. (23647063)
2014
3
Lifestyle factors, autoimmune disease and family history in prognosis of non-hodgkin lymphoma overall and subtypes. (23160780)
2013
4
B-cell non-Hodgkin lymphoma of the ethmoid sinus. (23670337)
2013
5
Darbepoetin alfa administration in patients with non-Hodgkin lymphoma and chemotherapy-induced anemia receiving (A+R) CHOP. (22980138)
2013
6
Bortezomib may be safely combined with Y-90-ibritumomab tiuxetan in patients with relapsed/refractory follicular non-Hodgkin lymphoma: a phase I trial of combined induction therapy and bortezomib consolidation. (22906230)
2013
7
Preliminary results of radiotherapy for primary intraocular non-Hodgkin lymphoma. (23343177)
2013
8
Investigation of epstein-barr virus as a potential cause of B-cell non-Hodgkin lymphoma in a prospective cohort. (23885038)
2013
9
Lupus nephritis and non-Hodgkin lymphoma simultaneously diagnosed in a patient on methimazole. (23263868)
2013
10
What is the role of stem-cell transplantation for follicular non-hodgkin lymphoma in the rituximab era? (23547074)
2013
11
Raising awareness of non-Hodgkin lymphoma in HIV-infected adolescents: report of 2 cases in the HAART era. (23426000)
2013
12
Anti-CD20 and CD22 therapy is effective in non-Hodgkin lymphoma. (23475897)
2013
13
Epidemiology of non-Hodgkin lymphoma. (23958141)
2013
14
Rituximab plus bendamustine for the treatment of aggressive non-hodgkin lymphoma patients with severe liver impairment. (23598989)
2013
15
Gemcitabine and vinorelbine chemotherapy for refractory or relapsing aggressive non-Hodgkin lymphoma. (22422565)
2012
16
Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma. (22649007)
2012
17
Pesticide use, immunologic conditions, and risk of non-Hodgkin lymphoma in Canadian men in six provinces. (22396152)
2012
18
Prognosis and outcome of non-Hodgkin lymphoma in primary SjAPgren syndrome. (22198497)
2012
19
Polymorphisms in immune function genes and non-Hodgkin lymphoma survival. (22113576)
2012
20
Is rituximab approved in pediatric non Hodgkin lymphoma? (22700674)
2012
21
Roles and limitations of FDG PET in pediatric non-Hodgkin lymphoma. (22691506)
2012
22
Lymphoma, thymoma and the wooden man: stiff-person syndrome post-thymoma excision and non-Hodgkin lymphoma remission. (22356495)
2012
23
Current understanding of lifestyle and environmental factors and risk of non-hodgkin lymphoma: an epidemiological update. (23008714)
2012
24
An unusual presentation of primary rib non hodgkins lymphoma masquerading as male breast cancer. (24293968)
2012
25
Reduced pretreatment ovarian reserve in premenopausal female patients with Hodgkin lymphoma or non-Hodgkin-lymphoma--evaluation by using antimA1llerian hormone and retrieved oocytes. (22607891)
2012
26
Sexual well-being among survivors of non-Hodgkin lymphoma. (21875831)
2011
27
Erratum: Non-Hodgkin lymphoma presenting with numb chin syndrome. (22110559)
2011
28
Prediagnostic serum levels of cytokines and other immune markers and risk of non-hodgkin lymphoma. (21632552)
2011
29
Spatial-temporal analysis of non-Hodgkin lymphoma in the NCI-SEER NHL case-control study. (21718483)
2011
30
No association between the TP53 codon 72 polymorphism and risk or prognosis of Hodgkin and non-Hodgkin lymphoma. (21546086)
2011
31
SUVmax in FDG-PET at the biopsy site correlates with the proliferation potential of tumor cells in non-Hodgkin lymphoma. (20038236)
2010
32
Immunohistochemical localization of cellular NFATc1 does not predict clinical responses to ciclosporin in subcutaneous panniculitis-like T-cell non-Hodgkin lymphoma. (20096007)
2010
33
Langerhans cell histiocytosis in a child with non-Hodgkin lymphoma. (20628318)
2010
34
TERC telomerase subunit gene copy number in different disease stages of non-hodgkin lymphoma and in hepatitis C. (20121548)
2010
35
Treatment of therapy-related acute myeloid leukemia occurring in elderly non-Hodgkin lymphoma patients with low-dose cytarabine, aclarubicin and granulocyte colony-stimulating factor. (18472159)
2009
36
Genetic polymorphisms in glutathione S-transferases and cytochrome P450s, tobacco smoking, and risk of non-Hodgkin lymphoma. (19338043)
2009
37
P38 mitogen activated protein kinase expression and regulation by interleukin-4 in human B cell non-Hodgkin lymphomas. (20309428)
2009
38
Serum level of soluble human leukocyte antigen-G molecules in non-Hodgkin lymphoma: does it have a prognostic value? (18608865)
2008
39
Expansion of Vdelta1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16-binding proteins. (16973957)
2007
40
Inhibitory effect of triptolide on lymph node metastasis in patients with non-Hodgkin lymphoma by regulating SDF-1/CXCR4 axis in vitro. (17049119)
2006
41
Association between telomere length and BCL2 gene rearrangements in low- and high-grade non-Hodgkin lymphomas. (17074584)
2006
42
t(14;22)(q32;q11) in non-Hodgkin lymphoma and myeloid leukaemia: molecular cytogenetic investigations. (16156854)
2005
43
Intensive sequential chemotherapy with hematopoietic growth factor support for non-Hodgkin lymphoma in patients infected with the human immunodeficiency virus. (14770420)
2004
44
Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma. (15159310)
2004
45
Pulmonary asbestosis associated to pleural non-Hodgkin lymphoma. (10228504)
1999
46
Involvement of BCL6 in chromosomal aberrations affecting band 3q27 in B-cell non-Hodgkin lymphoma. (9824205)
1998
47
Expression of cytotoxic molecules in intestinal T-cell lymphomas. The German Study Group on Intestinal Non-Hodgkin Lymphoma. (9349234)
1997
48
Presence of the bcl-2 protein and apoptosis in non-Hodgkin lymphomas with diffuse growth pattern. (7790118)
1995
49
t(8;13) (p11;q12) translocation in a myeloproliferative disorder associated with a T-cell non-Hodgkin lymphoma. (7918088)
1994
50
Precursor Langerhans cell histiocytosis. An unusual histiocytic proliferation in a patient with persistent non-Hodgkin lymphoma and terminal acute monocytic leukemia. (1617604)
1992

Genetic Variations for Non-Hodgkin Lymphoma

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Non-Hodgkin Lymphoma:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly469AlaVAR_018620
2BRAFp.Gly469ArgVAR_018622
3BRAFp.Asp594GlyVAR_018624
4CASP10p.Ala414ValVAR_037430rs28936699

Expression for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Non-Hodgkin Lymphoma

Search GEO for disease gene expression data for Non-Hodgkin Lymphoma.

Pathways for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 55SinoBiological, 52R&D Systems, 12EMD Millipore
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Pathways related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5BRAF, CASP10, CSF3, TNFSF8, MDM2, LTA
2
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11.4BRAF, CASP10, CSF3, TNFSF8, LTA, BCL2
3
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11.2BCL2, LTA, PRF1, MDM2, CASP10
4
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11.2BCL2, LTA, MDM2, CASP10, BRAF
5
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11.2CASP10, CSF3, TNFSF8, LTA, BCL2
6
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11.2CSF3, TNFSF8, MDM2, LTA, BCL2
7
Hide members
11.1BCL2, LTA, TNFSF8, CASP10
811.1CASP10, MDM2, BCL6, BCL2
9
Apoptosis and survival Caspase cascade
Hide members
10.9BCL2, PRF1, CASP10
10
Hide members
10.9BCL2, LTA, PRF1
11
Hide members
10.9CASP10, MDM2, BCL2
1210.9BRAF, MDM2, BCL2
13
Hide members
10.9BCL2, MDM2, BRAF
1410.9CASP10, BCL6, BCL2

Compounds for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
See all sources

Compounds related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1paraffin4411.9BRAF, CT49, MDM2, LTA, MS4A1, BCL6
2cyclophosphamide44 49 1113.7GSTM3, BCL2, BCL6, MS4A1, MDM2, CSF3
3cisplatin44 49 59 1114.7BRAF, CASP10, CSF3, MDM2, BCL2, GSTM3
4vegf4411.7BRAF, CSF3, CT49, MDM2, LTA, BCL2
5imatinib44 49 1113.6BRAF, CSF3, MDM2, BCL6, BCL2
6doxorubicin44 49 1113.5CSF3, MDM2, NBN, BCL6, BCL2
7serine4411.4CASP10, CT49, LTA, NBN
8retinoic acid44 2412.4BRAF, CSF3, CT49, LTA, BCL6, BCL2
9fludarabine44 1112.4BCL2, MS4A1, MDM2, CSF3
10rituximab44 49 1113.4CSF3, MS4A1, BCL6, BCL2
11mitomycin c4411.4CSF3, MDM2, NBN, BCL2
12vincristine44 49 1113.4CSF3, MDM2, BCL6, BCL2
13paclitaxel44 49 1113.4BRAF, CSF3, MDM2, BCL2
14agar4411.3PRF1, MDM2, CT49, BRAF
15etoposide44 49 59 1114.3BCL2, NBN, MDM2, CSF3
162-chlorodeoxyadenosine4411.2BCL2, MDM2, CSF3
17progesterone44 59 28 11 2415.2BRAF, CT49, MDM2, LTA, BCL2
18oligonucleotide4411.2BCL2, LTA, MDM2, CT49, BRAF
19daunorubicin44 49 1113.2CSF3, MDM2, BCL2
20irinotecan44 49 1113.1BRAF, CSF3, MDM2
21carboplatin44 49 1113.1BCL2, MDM2, CSF3
22rapamycin4411.0BCL2, NBN, MDM2, BRAF
23cycloheximide4411.0LTA
2410-hydroxycamptothecin4410.9BCL2, MDM2
25vinblastine44 49 1112.9MDM2
26estrogen4410.8BCL6
27thymidylate4410.6MDM2, SHMT1, BCL2

GO Terms for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
16Gene Ontology
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Cellular components related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.8BCL6, NBN

Biological processes related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:00691511.3BCL2, CASP10, TNFSF8, PRF1, LTA, NBN
2response to iron ionGO:01003910.8BCL2, MDM2
3positive regulation of peptidyl-serine phosphorylationGO:03313810.6BCL2, CSF3, BRAF

Products for genes affiliated with Non-Hodgkin Lymphoma

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  • Antibodies
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Sources for Non-Hodgkin Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet