MCID: NNH001
MIFTS: 72

Non-Hodgkin Lymphoma malady

Cancer diseases, Immune diseases categories

Summaries for Non-Hodgkin Lymphoma

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46OMIM, 32MalaCards
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MalaCards: Non-Hodgkin Lymphoma, also known as lymphoma, non-hodgkin, is related to leukemia and hepatitis. An important gene associated with Non-Hodgkin Lymphoma is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The drugs mercaptopurine and carmustine and the compounds paraffin and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related mouse phenotypes are immune system and hematopoietic system.

Description from OMIM:46 605027

Aliases & Classifications for Non-Hodgkin Lymphoma

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Sources:
8Disease Ontology, 30LifeMap Discovery™, 9diseasecard, 46OMIM, 60UMLS, 44Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

non-hodgkin lymphoma 8 30
lymphoma, non-hodgkin 9 46 60
lymphoma non-hodgkins 44


External Ids:

Disease Ontology8 DOID:0060060
OMIM46 605027
ICD1025 C85.7

Related Diseases for Non-Hodgkin Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Non-Hodgkin Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.4CASP10, CSF3, MDM2, LTA, NBN, BCL6
2hepatitis31.1LTA
3chronic lymphocytic leukemia31.1CASP10, MDM2, LTA, MS4A1, BCL6, BCL2
4acute leukemia31.0CSF3
5mantle cell lymphoma30.9MDM2, BCL6, BCL2
6myeloma30.8CSF3, LTA, BCL6, BCL2
7multiple myeloma30.7CSF3
8sarcoma30.6MDM2, BRAF
9neutropenia30.6CSF3
10pneumonia30.6PRF1, CSF3
11burkitt's lymphoma30.6BCL2, BCL6, MS4A1, MDM2
12anaplastic large cell lymphoma30.5BCL6, TNFSF8
13breast cancer30.4BRAF, CASP10, CSF3, MDM2, SHMT1, NBN
14adenocarcinoma30.4BRAF, CT49, MDM2, BCL2
15myeloid leukemia30.4BCL2, LTA, CSF3
16familial non-hodgkin lymphoma30.3CASP10, BRAF
17ataxia telangiectasia30.3MDM2, NBN
18colorectal cancer30.3BCL2, NBN, MDM2, BRAF
19central nervous system lymphoma30.3BCL6
20hodgkin's lymphoma30.1CSF3, TNFSF8, MDM2, LTA, MS4A1, BCL6
21melanoma30.1BRAF, CASP10, CT49, MDM2, PRF1, NBN
22lymphoma, diffuse large cell30.1MS4A1, BCL6, BCL2
23lung cancer30.1CSF3, BCL2
24bladder carcinoma30.1MDM2, LTA
25arthritis30.1LTA
26basal cell carcinoma30.1GSTM3, BCL2, LTA
27liposarcoma30.1MDM2
28rhabdomyosarcoma30.1MDM2
29malignant mesothelioma30.1CT49
30hepatitis c10.6
31hepatitis b10.6
32adult lymphoma10.6
33diffuse large b-cell lymphoma10.6
34bone lymphoma10.6
35pediatric lymphoma10.6
36hepatitis a10.6
37breast lymphoma10.5
38lymphoblastic leukemia10.5
39cryoglobulinemia10.4
40obstructive jaundice10.4
41gastric lymphoma10.4
42acquired immunodeficiency syndrome10.4
43orbit lymphoma10.4
44autoimmune hemolytic anemia10.4
45childhood leukemia10.4
46hemolytic anemia10.4
47liver lymphoma10.3
48heart lymphoma10.3
49ovarian lymphoma10.3
50progressive multifocal leukoencephalopathy10.3

Graphical network of the top 20 diseases related to Non-Hodgkin Lymphoma:



Diseases related to non-hodgkin lymphoma

Clinical Features for Non-Hodgkin Lymphoma

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Sources:
46OMIM
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Clinical features from OMIM:

605027

Drugs & Therapeutics for Non-Hodgkin Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Non-Hodgkin Lymphoma

Drug clinical trials:

Search ClinicalTrials for Non-Hodgkin Lymphoma

Search NIH Clinical Center for Non-Hodgkin Lymphoma

Search CenterWatch for Non-Hodgkin Lymphoma

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Non-Hodgkin Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Non-Hodgkin Lymphoma

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Anatomical Context for Non-Hodgkin Lymphoma

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Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Non-Hodgkin Lymphoma:

32
B cells, T cells, Bone, Bone marrow, Breast, Myeloid, Endothelial, Monocytes, Heart, Prostate, Liver, Skin, Brain, Spinal cord, Thyroid, Cervix, Nk cells, Pituitary, Testes, Lung, Lymph node, Kidney, Tongue, Ovary, B lymphoblasts

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Non-Hodgkin Lymphoma:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Non-Hodgkin Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Non-Hodgkin Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.2BCL2, BRAF, CSF3, TNFSF8, MDM2, RHOH
2MP:000539712.0RHOH, MDM2, CSF3, BRAF, PRF1, LTA
3MP:000538411.8MDM2, RHOH, PRF1, LTA, MS4A1, NBN
4MP:000537011.1BRAF, MDM2, PRF1, SHMT1, LTA, BCL6
5MP:000200610.8BRAF, MDM2, SHMT1

Publications for Non-Hodgkin Lymphoma

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Sources:
50PubMed
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Articles related to Non-Hodgkin Lymphoma:

(show top 50)    (show all 908)
idTitleAuthorsYear
1
90Yttrium-ibritumomab tiuxetan consolidation of first remission in advanced-stage follicular non-Hodgkin lymphoma: updated results after a median follow-up of 7.3 years from the International, Randomized, Phase III First-LineIndolent trial. (23547079)
2013
2
Successful surgical treatment for pulmonary crystal-storing histiocytosis following the onset of gastric non-hodgkin lymphoma. (24369227)
2013
3
Mapping of the IRF8 gene identifies a 3'UTR variant associated with risk of chronic lymphocytic leukemia but not other common non-Hodgkin lymphoma subtypes. (23307532)
2013
4
Non-Hodgkin lymphoma in the periapical region of a mandibular canine. (23683289)
2013
5
Pre-diagnosis cigarette smoking and overall survival in non-Hodgkin lymphoma. (23909494)
2013
6
Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non-Hodgkin lymphoma: results of a phase I/II study evaluating the immunoconjugate inotuzumab ozogamicin with rituximab. (23295790)
2013
7
Case-control study of risk factors for Non-Hodgkin lymphoma in Mumbai, India. (23621236)
2013
8
Correlation between increased circulating endothelial progenitor cells and stage of non-Hodgkin lymphoma. (23592145)
2013
9
Central pontine myelinolysis in a patient with non-Hodgkin lymphoma. (23384152)
2013
10
Hepatitis B infection increases the risk of non-Hodgkin lymphoma: a meta-analysis of observational studies. (23809055)
2013
11
Polymorphisms in DNA repair pathway genes, body mass index, and risk of non-Hodgkin lymphoma. (23619945)
2013
12
Postmenopausal hormone therapy and non-Hodgkin lymphoma: a pooled analysis of InterLymph case-control studies. (22967995)
2013
13
Analysis of very elderly (a8Y80 years) non-hodgkin lymphoma: impact of functional status and co-morbidities on outcome. (22084970)
2012
14
Self-reported history of infections and the risk of non-Hodgkin lymphoma: an InterLymph pooled analysis. (22266776)
2012
15
RIT with Y90-Ibritumomab Tiuxetan in Follicular Non-Hodgkin Lymphoma: Evaluation of Recent Outcomes in a Single Institution. (23049552)
2012
16
The characterization of PDGFR-alpha and PDGFR-beta expression in malignant non-Hodgkin lymphoma. (23188435)
2012
17
Fine needle cytology, infectious diseases and non-Hodgkin lymphoma. (23069693)
2012
18
Impact of palifermin on mucosal toxicity in autologous stem cell transplants using busulfan-melphalan conditioning chemotherapy for Hodgkin and non-Hodgkin lymphoma. (22204452)
2012
19
Pediatric non-Hodgkin lymphoma: a retrospective 14-year experience with Berlin-Frankfurt-MA1nster (BFM) protocols from a tertiary care hospital in Serbia. (22376014)
2012
20
Endobronchial involvement in non-Hodgkin lymphoma. (23207359)
2012
21
Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies. (22496152)
2012
22
Hepatitis C virus cryoglobulinemia and non-hodgkin lymphoma. (22509184)
2012
23
Null phenotype non-Hodgkin lymphoma presenting as a large chest wall mass: case report. (23396644)
2012
24
Epidemiology, Diagnosis, and Treatment of HIV-Associated Non-Hodgkin Lymphoma in Resource-Limited Settings. (22548067)
2012
25
Hepatitis C and non-Hodgkin lymphoma: the clinical perspective. (22120959)
2012
26
Severe left main coronary stenosis in a young female patient, 6 years after mediastinal radiation therapy for non-Hodgkin lymphoma: assessment by coronary angiography and intravascular ultrasound. (22286318)
2012
27
Risk Factors of Non-Hodgkin Lymphoma. (22059093)
2011
28
High serum angiogenin at diagnosis predicts for failure on long-term treatment response and for poor overall survival in non-Hodgkin lymphoma. (21439815)
2011
29
Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies. (20813000)
2010
30
Phase 2 study of intrathecal, long-acting liposomal cytarabine in the prophylaxis of lymphomatous meningitis in human immunodeficiency virus-related non-Hodgkin lymphoma. (20108270)
2010
31
Leptospirosis in a case of non-Hodgkin lymphoma. (21252467)
2010
32
A 19-year follow-up of a patient with type 3 ectrodactyly-ectodermal dysplasia-clefting syndrome who developed non-Hodgkin lymphoma. (19716498)
2009
33
Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma. (19396635)
2009
34
Total body irradiation, etoposide, cyclophosphamide, and autologous peripheral blood stem-cell transplantation followed by randomization to therapy with interleukin-2 versus observation for patients with non-Hodgkin lymphoma: results of a phase 3 randomized trial by the Southwest Oncology Group (SWOG 9438). (18256325)
2008
35
Association between folate-metabolizing pathway polymorphism and non-Hodgkin lymphoma. (18042267)
2008
36
Role of gelatinases (MMP-2 and MMP-9), TIMP-1, vascular endothelial growth factor (VEGF), and microvessel density on the clinicopathological behavior of childhood non-Hodgkin lymphoma. (18231955)
2008
37
One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia. (17891500)
2007
38
Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. (17827388)
2007
39
Recombinant interleukin-2 significantly augments activity of rituximab in human tumor xenograft models of B-cell non-Hodgkin lymphoma. (17198084)
2007
40
Polymorphisms in immune function genes and risk of non-Hodgkin lymphoma: findings from the New South Wales non-Hodgkin Lymphoma Study. (17056605)
2007
41
cFLIP expression correlates with tumour progression and patient outcome in non-Hodgkin lymphomas of low grade of malignancy. (16445828)
2006
42
Familial aggregation of lymphoplasmacytic lymphoma with non-Hodgkin lymphoma and other neoplasms. (16224483)
2005
43
Primary non-Hodgkin lymphoma of the humerus following traumatic injury: case report. (14579239)
2003
44
Human leukocyte antigens class II and tumor necrosis factor genetic polymorphisms are independent predictors of non-Hodgkin lymphoma outcome. (12351419)
2002
45
Translocation (1;11)(q23;p15), a novel simple variant of translocation (7;11)(p15;p15), in a patient with AML (M2) accompanied by non-Hodgkin lymphoma and gastric cancer. (10700860)
2000
46
How reliable is histologic examination of bone marrow trephine biopsy specimens for the staging of non-Hodgkin lymphoma? A study of hairy cell leukemia and mantle cell lymphoma involvement of the bone marrow trephine specimen by histologic, immunohistochemical, and polymerase chain reaction techniques. (9930138)
1999
47
New agents for the treatment of multiple myeloma and non-Hodgkin lymphoma. (1638466)
1992
48
Simultaneous assay of adenosine deaminase and purine nucleoside phosphorylase activity as possible biochemical means to detect non-Hodgkin lymphomas of the oral cavity. (1606542)
1992
49
Primary non-Hodgkin malignant lymphoma of the breast. An immunohistochemical study of seven patients and literature review of 152 patients with breast lymphoma in Japan. (1423175)
1992
50
Richter's syndrome with identical immunoglobulin gene rearrangements in the chronic lymphocytic leukemia and the supervening non-Hodgkin lymphoma. (2811481)
1989

Genetic Variations for Non-Hodgkin Lymphoma

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Non-Hodgkin Lymphoma:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly469AlaVAR_018620
2BRAFp.Gly469ArgVAR_018622
3BRAFp.Asp594GlyVAR_018624
4CASP10p.Ala414ValVAR_037430rs28936699

Expression for genes affiliated with Non-Hodgkin Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Non-Hodgkin Lymphoma

Search GEO for disease gene expression data for Non-Hodgkin Lymphoma.

Pathways for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 55SinoBiological, 52R&D Systems, 12EMD Millipore
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Pathways related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5BRAF, CASP10, CSF3, TNFSF8, MDM2, LTA
2
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11.4BRAF, CASP10, CSF3, TNFSF8, LTA, BCL2
3
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11.2BCL2, LTA, PRF1, MDM2, CASP10
4
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11.2BCL2, LTA, MDM2, CASP10, BRAF
5
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11.2CASP10, CSF3, TNFSF8, LTA, BCL2
6
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11.2CSF3, TNFSF8, MDM2, LTA, BCL2
7
Hide members
11.1BCL2, LTA, TNFSF8, CASP10
811.1CASP10, MDM2, BCL6, BCL2
9
Apoptosis and survival Caspase cascade
Hide members
10.9BCL2, PRF1, CASP10
10
Hide members
10.9BCL2, LTA, PRF1
11
Hide members
10.9CASP10, MDM2, BCL2
1210.9BRAF, MDM2, BCL2
13
Hide members
10.9BCL2, MDM2, BRAF
1410.9CASP10, BCL6, BCL2

Compounds for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1paraffin4411.9BRAF, CT49, MDM2, LTA, MS4A1, BCL6
2cyclophosphamide44 49 1113.7GSTM3, BCL2, BCL6, MS4A1, MDM2, CSF3
3cisplatin44 49 59 1114.7BRAF, CASP10, CSF3, MDM2, BCL2, GSTM3
4vegf4411.7BRAF, CSF3, CT49, MDM2, LTA, BCL2
5imatinib44 49 1113.6BRAF, CSF3, MDM2, BCL6, BCL2
6doxorubicin44 49 1113.5CSF3, MDM2, NBN, BCL6, BCL2
7serine4411.4CASP10, CT49, LTA, NBN
8retinoic acid44 2412.4BRAF, CSF3, CT49, LTA, BCL6, BCL2
9fludarabine44 1112.4BCL2, MS4A1, MDM2, CSF3
10rituximab44 49 1113.4CSF3, MS4A1, BCL6, BCL2
11mitomycin c4411.4CSF3, MDM2, NBN, BCL2
12vincristine44 49 1113.4CSF3, MDM2, BCL6, BCL2
13paclitaxel44 49 1113.4BRAF, CSF3, MDM2, BCL2
14agar4411.3PRF1, MDM2, CT49, BRAF
15etoposide44 49 59 1114.3BCL2, NBN, MDM2, CSF3
162-chlorodeoxyadenosine4411.2BCL2, MDM2, CSF3
17progesterone44 59 28 11 2415.2BRAF, CT49, MDM2, LTA, BCL2
18oligonucleotide4411.2BCL2, LTA, MDM2, CT49, BRAF
19daunorubicin44 49 1113.2CSF3, MDM2, BCL2
20irinotecan44 49 1113.1BRAF, CSF3, MDM2
21carboplatin44 49 1113.1BCL2, MDM2, CSF3
22rapamycin4411.0BCL2, NBN, MDM2, BRAF
23cycloheximide4411.0LTA
2410-hydroxycamptothecin4410.9BCL2, MDM2
25vinblastine44 49 1112.9MDM2
26estrogen4410.8BCL6
27thymidylate4410.6MDM2, SHMT1, BCL2

GO Terms for genes affiliated with Non-Hodgkin Lymphoma

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Sources:
16Gene Ontology
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Cellular components related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.8BCL6, NBN

Biological processes related to Non-Hodgkin Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apoptotic processGO:00691511.3BCL2, CASP10, TNFSF8, PRF1, LTA, NBN
2response to iron ionGO:01003910.8BCL2, MDM2
3positive regulation of peptidyl-serine phosphorylationGO:03313810.6BCL2, CSF3, BRAF

Products for genes affiliated with Non-Hodgkin Lymphoma

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  • Antibodies
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Sources for Non-Hodgkin Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet