NSCLC
MCID: NNS005
MIFTS: 67

Non-Small Cell Lung Carcinoma (NSCLC) malady

Genetic diseases (common), Cancer diseases, Respiratory diseases categories

Summaries for Non-Small Cell Lung Carcinoma

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Disease Ontology:9 A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.

MalaCards based summary: Non-Small Cell Lung Carcinoma, also known as nonsmall cell lung cancer, is related to lung cancer and interstitial lung disease. An important gene associated with Non-Small Cell Lung Carcinoma is EGFR (epidermal growth factor receptor), and among its related pathways are Dorso-ventral axis formation and EGFR Transactivation by Gastrin. The drugs hydroxyurea and vinorelbine and the compounds panitumumab and regorafenib have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and lymph node, and related mouse phenotypes are tumorigenesis and integument.

Wikipedia:64 Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung... more...

Description from OMIM:46 211980

Aliases & Classifications for Non-Small Cell Lung Carcinoma

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Non-Small Cell Lung Carcinoma, Aliases & Descriptions:

Name: Non-Small Cell Lung Carcinoma 31 9 11 61
Nonsmall Cell Lung Cancer 10 23 46
Non-Small Cell Lung Cancer 9 61
 
Nsclc 9 44
Carcinoma Non-Small Cell Lung 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology9 DOID:3908
NCIt39 C2926
SNOMED-CT56 254637007
MeSH34 D002289

Related Diseases for Non-Small Cell Lung Carcinoma

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Diseases related to Non-Small Cell Lung Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer31.2EGFR, PIK3CA, NKX2-1, KRAS
2interstitial lung disease31.0NKX2-1, EGFR
3pancreatic cancer30.8FASLG, KRAS, EGFR
4adenocarcinoma30.7EGFR, KRAS, PIK3CA, BRAF, XAGE1D, NKX2-1
5lung adenocarcinoma30.5EGFR, KRAS, XAGE1D, BRAF, PIK3CA, NKX2-1
6squamous cell carcinoma of the head and neck30.4EGFR, FASLG, PIK3CA
7ovarian cancer30.2KRAS, NKX2-1, FASLG, EGFR, BRAF, PIK3CA
8melanoma30.1BRAF, PPP2R1B, XAGE1D, PIK3CA, NKX2-1, KRAS
9glioblastoma multiforme30.1PIK3CA, EGFR, FASLG
10colorectal cancer29.7KRAS, PPP2R1B, EGFR, FASLG, PIK3CA, BRAF
11breast cancer29.2BRAF, EGFR, PPP2R1B, SLC22A18, KRAS, PIK3CA
12endotheliitis11.0
13mediastinitis10.7
14pulmonary fibrosis10.7
15idiopathic pulmonary fibrosis10.7
16retinoblastoma10.7
17lung cancer susceptibility10.6
18pulmonary blastoma10.6NKX2-1
19struma ovarii10.6NKX2-1
20thrombocytosis10.6
21pancreatitis10.6
22pneumothorax10.6
23spontaneous pneumothorax10.6
24nonsmall cell lung cancer, somatic10.5
25oligodendroglioma10.5EGFR, BRAF
26leukemia10.5
27paraneoplastic syndromes10.5
28neuroblastoma10.5
29toxic epidermal necrolysis10.5
30rhabdomyosarcoma10.5SLC22A18
31follicular thyroid carcinoma10.4BRAF, NKX2-1
32nonsmall cell lung cancer, response to tyrosine kinase inhibitor in10.4
33cardiofaciocutaneous syndrome10.4KRAS, BRAF
34chronic obstructive pulmonary disease10.4
35choroiditis10.4
36encephalitis10.4
37esophagitis10.4
38lung squamous cell carcinoma10.4
39thyroiditis10.4
40hypoxia10.4
41blindness10.4
42selection of therapeutic option in non-small cell lung carcinoma10.4
43costello syndrome10.4KRAS, BRAF
44wilms tumor10.4
45neuroendocrine carcinoma10.4
46large cell neuroendocrine carcinoma10.4
47xeroderma pigmentosum10.4
48conjunctivitis10.4
49pericardial effusion10.4
50mutagen sensitivity10.4

Graphical network of the top 20 diseases related to Non-Small Cell Lung Carcinoma:



Diseases related to non-small cell lung carcinoma

Symptoms for Non-Small Cell Lung Carcinoma

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Clinical features from OMIM:

211980

Drugs & Therapeutics for Non-Small Cell Lung Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Non-Small Cell Lung Carcinoma

Search NIH Clinical Center for Non-Small Cell Lung Carcinoma

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Non-Small Cell Lung Carcinoma

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Genetic tests related to Non-Small Cell Lung Carcinoma:

id Genetic test Affiliating Genes
1 Non-Small Cell Lung Cancer23

Anatomical Context for Non-Small Cell Lung Carcinoma

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MalaCards organs/tissues related to Non-Small Cell Lung Carcinoma:

32
Lung, Endothelial, Lymph node, Brain, Bone, Testes, Testis, T cells, Kidney, Thyroid, Bronchial epithelium, Bone marrow, Liver, Breast, Prostate, B cells, Pituitary, Neutrophil

Animal Models for Non-Small Cell Lung Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Non-Small Cell Lung Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.0EGFR, KRAS, NKX2-1, FASLG, BRAF, PIK3CA
2MP:001077110.0EGFR, KEAP1, KRAS, FASLG, BRAF, PIK3CA
3MP:00053889.9BRAF, FASLG, NKX2-1, KRAS, KEAP1, EGFR
4MP:00053819.8BRAF, FASLG, NKX2-1, KRAS, KEAP1, EGFR
5MP:00053799.7PIK3CA, BRAF, FASLG, NKX2-1, KRAS, EGFR

Publications for Non-Small Cell Lung Carcinoma

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Articles related to Non-Small Cell Lung Carcinoma:

(show top 50)    (show all 772)
idTitleAuthorsYear
1
Inonotus obliquus-derived polysaccharide inhibits the migration and invasion of human non-small cell lung carcinoma cells via suppression of MMP-2 and MMP-9. (25270791)
2014
2
Outcomes Treating Stage Iii Non-Small Cell Lung Carcinoma with Curative-Intent Radiotherapy and Concurrent Carboplatin-Paclitaxel Chemotherapy. (25353367)
2014
3
Long-term survival after surgical treatment of metachronous bilateral adrenal metastases of non-small cell lung carcinoma. (25317919)
2014
4
CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. (23877438)
2013
5
Radical treatment of synchronous oligometastatic non-small cell lung carcinoma (NSCLC): patient outcomes and prognostic factors. (23973202)
2013
6
Level of plasmacytoid dendritic cells is increased in non-small cell lung carcinoma. (24136746)
2013
7
Additional weekly Cetuximab to concurrent chemoradiotherapy in locally advanced non-small cell lung carcinoma: Efficacy and safety outcomes of a randomized, multi-center phase II study investigating. (24225233)
2013
8
ROS1 receptor tyrosine kinase, a druggable target, is frequently overexpressed in non-small cell lung carcinomas via genetic and epigenetic mechanisms. (22915320)
2013
9
Therapeutic strategy for advanced EGFR mutant non-small-cell lung carcinoma. (23911281)
2013
10
Utilization of p40 (I9Np63) with p63 and cytokeratin 5/6 immunohistochemistry in non-small cell lung carcinoma fine-needle aspiration biopsy. (24107322)
2013
11
Concomitant EGFR inhibitors combined with radiation for treatment of non-small cell lung carcinoma. (24083690)
2013
12
Non-small-cell lung carcinoma subtyping on cytology without the use of immunohistochemistry - can we meet the challenge? (22846184)
2012
13
Evaluation of carboplatin dosing in non-small cell lung carcinoma patients using Calvert formula and Cockroft and Gault equation for glomerular filtration rate estimation. (23162654)
2012
14
Higher expression of EphA2 and ephrin-A1 is related to favorable clinicopathological features in pathological stage I non-small cell lung carcinoma. (22236865)
2012
15
Disseminated herpes simplex virus infection following epidermal growth factor tyrosine kinase inhibitor therapy for non-small-cell lung carcinoma. (23157525)
2012
16
Synergistic antitumor effect of I^-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells. (21904777)
2011
17
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma. (21878121)
2011
18
Multiple myeloma emerging after prolonged gefitinib treatment for non-small cell lung carcinoma. (21516269)
2011
19
The prognostic value of intraepithelial and stromal CD3-, CD117- and CD138-positive cells in non-small cell lung carcinoma. (20477813)
2010
20
CYFRA21-1 can predict the sensitivity to chemoradiotherapy of non-small-cell lung carcinoma. (20649505)
2010
21
Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach. (20068099)
2010
22
Gefitinib in combination with gemcitabine and carboplatin in never smokers with non-small cell lung carcinoma: a retrospective analysis. (19546820)
2009
23
Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor. (19509246)
2009
24
The efficiency of single agent docetaxel in patients with platinum-refractory non-small cell lung carcinoma. (18320363)
2008
25
Co-expression patterns of tumor-associated antigen genes by non-small cell lung carcinomas: implications for immunotherapy. (18094614)
2008
26
Multi-arterial infusion chemotherapy for non-small cell lung carcinoma--significance of detecting feeding arteries and tumor staining. (18243405)
2008
27
Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report. (18700972)
2008
28
EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. (18242762)
2008
29
MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. (18602365)
2008
30
Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma. (17541031)
2007
31
Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma. (17545606)
2007
32
High frequency of p16 promoter methylation in non-small cell lung carcinomas from Chile. (18449464)
2007
33
Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma. (17299390)
2007
34
Lung tissue and tumour-infiltrating T lymphocytes in patients with non-small cell lung carcinoma and chronic obstructive pulmonary disease (COPD): moderate/severe versus mild stage of COPD. (17949407)
2007
35
Clinical and prognostic significance of podoplanin-positive lymphatic vessel density in non-small cell lung carcinoma]. (17327058)
2006
36
Time delay and its effect on survival in malaysian patients with non-small cell lung carcinoma. (22589589)
2006
37
Long-term outcome after resection of non-small cell lung carcinoma complicated by pneumoconiosis. (16998679)
2006
38
A case of recurrent non-small-cell lung carcinoma and paraneoplastic Cushing's syndrome. (16352372)
2006
39
Interleukin-8 in non-small cell lung carcinoma: relation with angiogenic pattern and p53 alterations. (16125276)
2005
40
Preclinical anti-tumor activity of XR5944 in combination with carboplatin or doxorubicin in non-small-cell lung carcinoma. (16162971)
2005
41
The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. (12819188)
2003
42
Expression of vascular endothelial growth factor mRNA in non-small-cell lung carcinomas. (9888482)
1999
43
Expression of vascular endothelial growth factor (VEGF) and its two receptors (VEGF-R1-Flt1 and VEGF-R2-Flk1/KDR) in non-small cell lung carcinomas (NSCLCs): correlation with angiogenesis and survival. (10440746)
1999
44
Prognostic value of basic fibroblast growth factor and its receptor (FGFR-1) in patients with non-small cell lung carcinomas. (9274456)
1997
45
Recurrence and death in non-small cell lung carcinomas: a prognostic model using pathological parameters, microvessel count, and gene protein products. (9816269)
1996
46
Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance. (8957065)
1996
47
Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma. (7606711)
1995
48
bcl-2 protein in non-small-cell lung carcinoma. (8264763)
1994
49
Overexpression of oncoproteins in non-small cell lung carcinomas of smokers. (8389672)
1993
50
Elevated expression of thymidylate synthase in doxorubicin resistant human non small cell lung carcinomas. (1338282)
1992

Variations for Non-Small Cell Lung Carcinoma

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UniProtKB/Swiss-Prot genetic disease variations for Non-Small Cell Lung Carcinoma:

63
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Clinvar genetic disease variations for Non-Small Cell Lung Carcinoma:

7
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> T (p.Gly12Cys)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
2PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
3PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
4BRAFNM_004333.4(BRAF): c.1789C> G (p.Leu597Val)single nucleotide variantPathogenicrs121913369GRCh37Chr 7, 140453146: 140453146
5FASLGNM_000639.1(FASLG): c.-844C=single nucleotide variantPathogenic, risk factorrs763110GRCh37Chr 1, 172627498: 172627498
6PPP2R1BNM_181699.2(PPP2R1B): c.269G> A (p.Gly90Asp)single nucleotide variantPathogenicrs1805076GRCh37Chr 11, 111635566: 111635566
7SLC22A18NM_183233.2(SLC22A18): c.698C> T (p.Ser233Phe)single nucleotide variantPathogenicrs121909071GRCh37Chr 11, 2939260: 2939260

Expression for genes affiliated with Non-Small Cell Lung Carcinoma

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LifeMap Discovery
Genes differentially expressed in tissues of Non-Small Cell Lung Carcinoma patients vs. healthy controls: 31 (show all 400)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1SFTPCsurfactant protein CLung-6.580.000
2CLDN18claudin 18Lung-6.410.000
3ADH1Balcohol dehydrogenase 1B (class I), beta polypeptideLung-6.180.000
4KRT6Akeratin 6ALung+5.850.000
5AGERadvanced glycosylation end product-specific receptorLung-5.700.000
6MMP12matrix metallopeptidase 12 (macrophage elastase)Lung+5.630.000
7CLIC5chloride intracellular channel 5Lung-5.510.000
8AQP4aquaporin 4Lung-5.290.000
9CYP4B1cytochrome P450, family 4, subfamily B, polypeptide 1Lung-5.270.000
10SPRR1Bsmall proline-rich protein 1BLung+5.250.000
11AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase)Lung+5.160.000
12MMP1matrix metallopeptidase 1 (interstitial collagenase)Lung+5.110.000
13KRT6Bkeratin 6BLung+5.100.000
14TMEM100transmembrane protein 100Lung-5.070.000
15FABP4fatty acid binding protein 4, adipocyteLung-5.030.000
16GKN2gastrokine 2Lung-4.990.000
17FAM107Afamily with sequence similarity 107, member ALung-4.950.000
18MT1Mmetallothionein 1MLung-4.940.000
19CPB2carboxypeptidase B2 (plasma)Lung-4.880.000
20KRT17keratin 17Lung+4.870.000
21S100A2S100 calcium binding protein A2Lung+4.840.000
22SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 5Lung+4.830.000
23GJB2gap junction protein, beta 2, 26kDaLung+4.780.000
24SPRR1Asmall proline-rich protein 1ALung+4.770.000
25KRT5keratin 5Lung+4.730.000
26GPM6Aglycoprotein M6ALung-4.710.000
27GREM1gremlin 1, DAN family BMP antagonistLung+4.690.000
28COL11A1collagen, type XI, alpha 1Lung+4.680.000
29TOP2Atopoisomerase (DNA) II alpha 170kDaLung+4.660.000
30GJB6gap junction protein, beta 6, 30kDaLung+4.620.000
31PEBP4phosphatidylethanolamine-binding protein 4Lung-4.610.000
32DSTdystoninLung+4.520.000
33TNNC1troponin C type 1 (slow)Lung-4.460.000
34DSG3desmoglein 3Lung+4.450.000
35FIGFc-fos induced growth factor (vascular endothelial growth factor D)Lung-4.430.000
36C19orf59chromosome 19 open reading frame 59Lung-4.430.000
37CLEC3BC-type lectin domain family 3, member BLung-4.420.000
38SPRR3small proline-rich protein 3Lung+4.360.000
39FCN3ficolin (collagen/fibrinogen domain containing) 3Lung-4.340.000
40PSAT1phosphoserine aminotransferase 1Lung+4.330.000
41SPP1secreted phosphoprotein 1Lung+4.320.000
42KRT15keratin 15Lung+4.300.000
43KRT14keratin 14Lung+4.300.000
44GPX2glutathione peroxidase 2 (gastrointestinal)Lung+4.290.000
45SLC2A1solute carrier family 2 (facilitated glucose transporter), member 1Lung+4.270.000
46WIF1WNT inhibitory factor 1Lung-4.270.000
47SOX2SRY (sex determining region Y)-box 2Lung+4.250.000
48ABCA8ATP-binding cassette, sub-family A (ABC1), member 8Lung-4.250.000
49ANLNanillin, actin binding proteinLung+4.210.000
50SFTPDsurfactant protein DLung-4.200.000
51CA4carbonic anhydrase IVLung-4.180.000
52CD36CD36 molecule (thrombospondin receptor)Lung-4.170.000
53ADAMTS8ADAM metallopeptidase with thrombospondin type 1 motif, 8Lung-4.150.000
54CDC20cell division cycle 20Lung+4.130.000
55CLCA2chloride channel accessory 2Lung+4.110.000
56INMTindolethylamine N-methyltransferaseLung-4.090.000
57MAMDC2MAM domain containing 2Lung-4.050.000
58TMPRSS4transmembrane protease, serine 4Lung+4.050.000
59TPX2TPX2, microtubule-associatedLung+4.040.000
60RRM2ribonucleotide reductase M2Lung+4.020.000
61SCN7Asodium channel, voltage-gated, type VII, alpha subunitLung-4.010.000
62VEPH1ventricular zone expressed PH domain-containing 1Lung-4.010.000
63LRRK2leucine-rich repeat kinase 2Lung-4.010.000
64CHRDL1chordin-like 1Lung-3.990.000
65BIRC5baculoviral IAP repeat containing 5Lung+3.980.000
66KRT16keratin 16Lung+3.980.000
67ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)Lung+3.960.000
68COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)Lung-3.950.000
69PTHLHparathyroid hormone-like hormoneLung+3.950.000
70SUSD2sushi domain containing 2Lung-3.940.000
71IGF2BP3insulin-like growth factor 2 mRNA binding protein 3Lung+3.930.000
72TCF21transcription factor 21Lung-3.920.000
73PGCprogastricsin (pepsinogen C)Lung-3.920.000
74SCGB1A1secretoglobin, family 1A, member 1 (uteroglobin)Lung-3.910.000
75CCNB1cyclin B1Lung+3.910.000
76TP63tumor protein p63Lung+3.880.000
77WDR72WD repeat domain 72Lung+3.860.000
78DSC3desmocollin 3Lung+3.850.000
79NTSneurotensinLung+3.840.000
80CXCL14chemokine (C-X-C motif) ligand 14Lung+3.820.000
81FHL1four and a half LIM domains 1Lung-3.810.000
82DSPdesmoplakinLung+3.800.000
83CCNB2cyclin B2Lung+3.800.000
84GPR87G protein-coupled receptor 87Lung+3.790.000
85SFTPA2surfactant protein A2Lung-3.790.000
86DLGAP5discs, large (Drosophila) homolog-associated protein 5Lung+3.780.000
87EDNRBendothelin receptor type BLung-3.780.000
88SFTA2surfactant associated 2Lung-3.760.000
89KIAA0101KIAA0101Lung+3.760.000
90ADRB1adrenoceptor beta 1Lung-3.750.000
91EMCNendomucinLung-3.750.000
92FOSBFBJ murine osteosarcoma viral oncogene homolog BLung-3.730.000
93FAM150Bfamily with sequence similarity 150, member BLung-3.720.000
94SFTA3surfactant associated 3Lung-3.720.000
95CXCL2chemokine (C-X-C motif) ligand 2Lung-3.710.000
96AGR3anterior gradient 3Lung-3.700.000
97PDK4pyruvate dehydrogenase kinase, isozyme 4Lung-3.700.000
98FOLR1folate receptor 1 (adult)Lung-3.700.000
99C2orf40chromosome 2 open reading frame 40Lung-3.700.000
100LPLlipoprotein lipaseLung-3.690.000
101UBE2Cubiquitin-conjugating enzyme E2CLung+3.680.000
102FAM83Dfamily with sequence similarity 83, member DLung+3.670.000
103FMO2flavin containing monooxygenase 2 (non-functional)Lung-3.670.000
104CALML3calmodulin-like 3Lung+3.670.000
105SULF1sulfatase 1Lung+3.660.000
106TRIM29tripartite motif containing 29Lung+3.660.000
107SERPINB3serpin peptidase inhibitor, clade B (ovalbumin), member 3Lung+3.650.000
108COL10A1collagen, type X, alpha 1Lung+3.650.000
109STXBP6syntaxin binding protein 6 (amisyn)Lung-3.630.000
110TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)Lung+3.630.000
111CTHRC1collagen triple helix repeat containing 1Lung+3.630.000
112NOSTRINnitric oxide synthase traffickingLung-3.630.000
113SCGB3A2secretoglobin, family 3A, member 2Lung-3.620.000
114PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)Lung+3.620.000
115SELEselectin ELung-3.610.000
116BUB1BBUB1 mitotic checkpoint serine/threonine kinase BLung+3.600.000
117SPRR2Bsmall proline-rich protein 2BLung+3.590.000
118LIMCH1LIM and calponin homology domains 1Lung-3.590.000
119MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)Lung+3.580.000
120C7complement component 7Lung-3.570.000
121SDPRserum deprivation responseLung-3.560.000
122HBBhemoglobin, betaLung-3.550.000
123PTPRBprotein tyrosine phosphatase, receptor type, BLung-3.540.000
124CDCA7cell division cycle associated 7Lung+3.540.000
125BTNL9butyrophilin-like 9Lung-3.520.000
126CENPFcentromere protein F, 350/400kDaLung+3.510.000
127COL1A1collagen, type I, alpha 1Lung+3.510.000
128UHRF1ubiquitin-like with PHD and ring finger domains 1Lung+3.510.000
129SERPINB13serpin peptidase inhibitor, clade B (ovalbumin), member 13Lung+3.500.000
130PLA2G1Bphospholipase A2, group IB (pancreas)Lung-3.500.000
131PBKPDZ binding kinaseLung+3.500.000
132ANKRD29ankyrin repeat domain 29Lung-3.500.000
133SFTPBsurfactant protein BLung-3.490.000
134CENPAcentromere protein ALung+3.480.000
135GINS1GINS complex subunit 1 (Psf1 homolog)Lung+3.480.000
136CEP55centrosomal protein 55kDaLung+3.480.000
137SFTA1Psurfactant associated 1, pseudogeneLung-3.460.000
138TTKTTK protein kinaseLung+3.460.000
139PRC1protein regulator of cytokinesis 1Lung+3.440.000
140C4BPAcomplement component 4 binding protein, alphaLung-3.440.000
141CDK1cyclin-dependent kinase 1Lung+3.430.000
142ZNF385Bzinc finger protein 385BLung-3.430.000
143HPGDhydroxyprostaglandin dehydrogenase 15-(NAD)Lung-3.420.000
144MELKmaternal embryonic leucine zipper kinaseLung+3.420.000
145PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 1Lung+3.410.000
146ADAM12ADAM metallopeptidase domain 12Lung+3.410.000
147S100A7S100 calcium binding protein A7Lung+3.390.000
148DARCDuffy blood group, atypical chemokine receptorLung-3.390.000
149HSD17B6hydroxysteroid (17-beta) dehydrogenase 6Lung-3.390.000
150KRT13keratin 13Lung+3.390.000
151CACNA2D2calcium channel, voltage-dependent, alpha 2/delta subunit 2Lung-3.390.000
152MARCOmacrophage receptor with collagenous structureLung-3.380.000
153MAGEA3melanoma antigen family A, 3Lung+3.370.000
154KCNK3potassium channel, subfamily K, member 3Lung-3.360.000
155SLC6A8solute carrier family 6 (neurotransmitter transporter), member 8Lung+3.360.000
156OLR1oxidized low density lipoprotein (lectin-like) receptor 1Lung-3.340.000
157NEK2NIMA-related kinase 2Lung+3.340.000
158CDKN3cyclin-dependent kinase inhibitor 3Lung+3.310.000
159MAGEA6melanoma antigen family A, 6Lung+3.310.000
160FERMT1fermitin family member 1Lung+3.300.000
161KIF2Ckinesin family member 2CLung+3.290.000
162GPIHBP1glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1Lung-3.290.000
163ABI3BPABI family, member 3 (NESH) binding proteinLung-3.290.000
164C16orf89chromosome 16 open reading frame 89Lung-3.290.000
165UBE2Tubiquitin-conjugating enzyme E2T (putative)Lung+3.280.000
166ZBTB16zinc finger and BTB domain containing 16Lung-3.270.000
167ADIRFadipogenesis regulatory factorLung-3.260.000
168HHIPhedgehog interacting proteinLung-3.260.000
169CCNA2cyclin A2Lung+3.250.000
170AFF3AF4/FMR2 family, member 3Lung-3.250.000
171SCARA5scavenger receptor class A, member 5 (putative)Lung-3.240.000
172UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)Lung+3.230.000
173BUB1BUB1 mitotic checkpoint serine/threonine kinaseLung+3.230.000
174FAM189A2family with sequence similarity 189, member A2Lung-3.220.000
175CA12carbonic anhydrase XIILung+3.220.000
176SIX1SIX homeobox 1Lung+3.220.000
177PITX1paired-like homeodomain 1Lung+3.210.000
178OGNosteoglycinLung-3.210.000
179ID4inhibitor of DNA binding 4, dominant negative helix-loop-helix proteinLung-3.200.000
180SCGB3A1secretoglobin, family 3A, member 1Lung-3.200.000
181FOXM1forkhead box M1Lung+3.190.000
182IL6interleukin 6 (interferon, beta 2)Lung-3.190.000
183GLDNgliomedinLung-3.180.000
184ACADLacyl-CoA dehydrogenase, long chainLung-3.170.000
185CDH3cadherin 3, type 1, P-cadherin (placental)Lung+3.160.000
186PPBPpro-platelet basic protein (chemokine (C-X-C motif) ligand 7)Lung-3.160.000
187PLAC9placenta-specific 9Lung-3.160.000
188HS6ST2heparan sulfate 6-O-sulfotransferase 2Lung+3.140.000
189POSTNperiostin, osteoblast specific factorLung+3.140.000
190NUSAP1nucleolar and spindle associated protein 1Lung+3.140.000
191CD52CD52 moleculeLung-3.130.000
192LEPRleptin receptorLung-3.120.000
193TRIP13thyroid hormone receptor interactor 13Lung+3.100.000
194ECT2epithelial cell transforming 2Lung+3.090.000
195STX11syntaxin 11Lung-3.080.000
196MFAP4microfibrillar-associated protein 4Lung-3.080.000
197GPX3glutathione peroxidase 3 (plasma)Lung-3.070.000
198WDR66WD repeat domain 66Lung+3.070.000
199DAPL1death associated protein-like 1Lung+3.060.000
200DLC1deleted in liver cancer 1Lung-3.050.000
201SELENBP1selenium binding protein 1Lung-3.050.000
202AK4adenylate kinase 4Lung+3.040.000
203MACROD2MACRO domain containing 2Lung-3.030.000
204CFDcomplement factor D (adipsin)Lung-3.030.000
205MMP10matrix metallopeptidase 10 (stromelysin 2)Lung+3.030.000
206C1orf116chromosome 1 open reading frame 116Lung-3.030.000
207ALOX5arachidonate 5-lipoxygenaseLung-3.020.000
208TEKTEK tyrosine kinase, endothelialLung-3.020.000
209KIF11kinesin family member 11Lung+3.020.000
210KIF4Akinesin family member 4ALung+3.010.000
211NAPSAnapsin A aspartic peptidaseLung-3.010.000
212SLC1A1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1Lung-3.010.000
213FLRT3fibronectin leucine rich transmembrane protein 3Lung-3.010.000
214CX3CR1chemokine (C-X3-C motif) receptor 1Lung-3.010.000
215TK1thymidine kinase 1, solubleLung+3.010.000
216PRR11proline rich 11Lung+3.000.000
217LMO3LIM domain only 3 (rhombotin-like 2)Lung-3.000.000
218IL33interleukin 33Lung-2.990.000
219CYP2B7Pcytochrome P450, family 2, subfamily B, polypeptide 7, pseudogeneLung-2.990.000
220HMGA2high mobility group AT-hook 2Lung+2.990.000
221MCM2minichromosome maintenance complex component 2Lung+2.980.000
222COL6A6collagen, type VI, alpha 6Lung-2.980.000
223PIGRpolymeric immunoglobulin receptorLung-2.970.000
224MMP11matrix metallopeptidase 11 (stromelysin 3)Lung+2.960.000
225PI3peptidase inhibitor 3, skin-derivedLung+2.960.000
226CLIC3chloride intracellular channel 3Lung-2.960.000
227FRYfurry homolog (Drosophila)Lung-2.960.000
228AOC3amine oxidase, copper containing 3Lung-2.960.000
229LYVE1lymphatic vessel endothelial hyaluronan receptor 1Lung-2.940.000
230AURKAaurora kinase ALung+2.940.000
231JAM2junctional adhesion molecule 2Lung-2.940.000
232RGCCregulator of cell cycleLung-2.930.000
233SCELsciellinLung-2.930.000
234MS4A7membrane-spanning 4-domains, subfamily A, member 7Lung-2.920.000
235CXCL13chemokine (C-X-C motif) ligand 13Lung+2.920.000
236ZWINTZW10 interacting kinetochore proteinLung+2.910.000
237NDC80NDC80 kinetochore complex componentLung+2.910.000
238CEACAM5carcinoembryonic antigen-related cell adhesion molecule 5Lung+2.900.000
239PIP5K1Bphosphatidylinositol-4-phosphate 5-kinase, type I, betaLung-2.890.000
240FBP1fructose-1,6-bisphosphatase 1Lung-2.890.000
241PLEKHH2pleckstrin homology domain containing, family H (with MyTH4 domain) member 2Lung-2.890.000
242SLC39A8solute carrier family 39 (zinc transporter), member 8Lung-2.880.000
243GPR133G protein-coupled receptor 133Lung-2.860.000
244KIF20Akinesin family member 20ALung+2.860.000
245ITGA8integrin, alpha 8Lung-2.860.000
246THBS2thrombospondin 2Lung+2.850.000
247CHI3L2chitinase 3-like 2Lung-2.840.000
248CAB39Lcalcium binding protein 39-likeLung-2.830.000
249NUF2NUF2, NDC80 kinetochore complex componentLung+2.830.000
250NDNFneuron-derived neurotrophic factorLung-2.820.000
251CAV1caveolin 1, caveolae protein, 22kDaLung-2.820.000
252NMUneuromedin ULung+2.810.000
253LAMP3lysosomal-associated membrane protein 3Lung-2.810.000
254HMGB3high mobility group box 3Lung+2.810.000
255DSG2desmoglein 2Lung+2.800.000
256GIMAP8GTPase, IMAP family member 8Lung-2.800.000
257FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptideLung-2.800.000
258ARHGAP6Rho GTPase activating protein 6Lung-2.800.000
259LRRN3leucine rich repeat neuronal 3Lung-2.800.000
260ROBO4roundabout, axon guidance receptor, homolog 4 (Drosophila)Lung-2.800.000
261LDB2LIM domain binding 2Lung-2.790.000
262ARNTL2aryl hydrocarbon receptor nuclear translocator-like 2Lung+2.790.000
263CXCL3chemokine (C-X-C motif) ligand 3Lung-2.790.000
264CDO1cysteine dioxygenase type 1Lung-2.770.000
265FOXA2forkhead box A2Lung-2.770.000
266CENPUcentromere protein ULung+2.760.000
267SESN3sestrin 3Lung+2.760.000
268IRF6interferon regulatory factor 6Lung+2.750.000
269ANXA3annexin A3Lung-2.750.000
270CD69CD69 moleculeLung-2.750.000
271WISP2WNT1 inducible signaling pathway protein 2Lung-2.750.000
272FNDC1fibronectin type III domain containing 1Lung+2.740.000
273VSIG4V-set and immunoglobulin domain containing 4Lung-2.740.000
274PTPN21protein tyrosine phosphatase, non-receptor type 21Lung-2.740.000
275GCOM1GRINL1A complex locus 1Lung-2.740.000
276FXYD1FXYD domain containing ion transport regulator 1Lung-2.730.000
277DEPDC1DEP domain containing 1Lung+2.730.000
278SRD5A1steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)Lung+2.730.000
279SLC46A2solute carrier family 46, member 2Lung-2.730.000
280CAPN3calpain 3, (p94)Lung-2.730.000
281C1orf162chromosome 1 open reading frame 162Lung-2.730.000
282FBXO32F-box protein 32Lung+2.730.000
283LYPD3LY6/PLAUR domain containing 3Lung+2.730.000
284KIF23kinesin family member 23Lung+2.720.000
285HIGD1BHIG1 hypoxia inducible domain family, member 1BLung-2.720.000
286MKI67marker of proliferation Ki-67Lung+2.720.000
287DNASE1L3deoxyribonuclease I-like 3Lung-2.720.000
288AQP1aquaporin 1 (Colton blood group)Lung-2.720.000
289GINS2GINS complex subunit 2 (Psf2 homolog)Lung+2.710.000
290ADAMDEC1ADAM-like, decysin 1Lung+2.710.000
291CAV2caveolin 2Lung-2.710.000
292PGM5phosphoglucomutase 5Lung-2.710.000
293RMI2RecQ mediated genome instability 2Lung+2.700.000
294ADTRPandrogen-dependent TFPI-regulating proteinLung-2.690.000
295RGS13regulator of G-protein signaling 13Lung-2.690.000
296FOXE1forkhead box E1 (thyroid transcription factor 2)Lung+2.690.000
297TMEM125transmembrane protein 125Lung-2.690.000
298FOXF1forkhead box F1Lung-2.690.000
299FANCIFanconi anemia, complementation group ILung+2.690.000
300PPP1R14Aprotein phosphatase 1, regulatory (inhibitor) subunit 14ALung-2.680.000
301ADRB2adrenoceptor beta 2, surfaceLung-2.680.000
302PPAP2Cphosphatidic acid phosphatase type 2CLung+2.670.000
303GATA6GATA binding protein 6Lung-2.670.000
304FCN1ficolin (collagen/fibrinogen domain containing) 1Lung-2.670.000
305NR4A2nuclear receptor subfamily 4, group A, member 2Lung-2.660.000
306HMMRhyaluronan-mediated motility receptor (RHAMM)Lung+2.660.000
307ERO1LERO1-like (S. cerevisiae)Lung+2.660.000
308SOX17SRY (sex determining region Y)-box 17Lung-2.660.000
309S100A12S100 calcium binding protein A12Lung-2.650.000
310ARRB1arrestin, beta 1Lung-2.650.000
311SORBS1sorbin and SH3 domain containing 1Lung-2.650.000
312MSR1macrophage scavenger receptor 1Lung-2.650.000
313RFC4replication factor C (activator 1) 4, 37kDaLung+2.650.000
314GBP6guanylate binding protein family, member 6Lung+2.650.000
315IGFBP3insulin-like growth factor binding protein 3Lung+2.650.000
316ANGPT1angiopoietin 1Lung-2.640.000
317OIP5Opa interacting protein 5Lung+2.640.000
318CSRNP1cysteine-serine-rich nuclear protein 1Lung-2.640.000
319CDC45cell division cycle 45Lung+2.630.000
320CDCA3cell division cycle associated 3Lung+2.630.000
321SOX7SRY (sex determining region Y)-box 7Lung-2.630.000
322TPPP3tubulin polymerization-promoting protein family member 3Lung-2.630.000
323FRMD3FERM domain containing 3Lung-2.630.000
324AURKBaurora kinase BLung+2.630.000
325RHOJras homolog family member JLung-2.630.000
326HPGDShematopoietic prostaglandin D synthaseLung-2.630.000
327LONRF3LON peptidase N-terminal domain and ring finger 3Lung-2.630.000
328IGSF9immunoglobulin superfamily, member 9Lung+2.630.000
329FGRfeline Gardner-Rasheed sarcoma viral oncogene homologLung-2.620.000
330GPR116G protein-coupled receptor 116Lung-2.610.000
331DPEP2dipeptidase 2Lung-2.610.000
332HJURPHolliday junction recognition proteinLung+2.610.000
333COCHcochlinLung+2.600.000
334PERPPERP, TP53 apoptosis effectorLung+2.600.000
335KIF14kinesin family member 14Lung+2.600.000
336NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseLung-2.600.000
337KAL1Kallmann syndrome 1 sequenceLung-2.590.000
338LIFRleukemia inhibitory factor receptor alphaLung-2.590.000
339FAM162Bfamily with sequence similarity 162, member BLung-2.590.000
340RRADRas-related associated with diabetesLung-2.590.000
341GADD45Bgrowth arrest and DNA-damage-inducible, betaLung-2.580.000
342ABCA3ATP-binding cassette, sub-family A (ABC1), member 3Lung-2.580.000
343KCNT2potassium channel, subfamily T, member 2Lung-2.580.000
344COL1A2collagen, type I, alpha 2Lung+2.580.000
345SPOCK2sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2Lung-2.580.000
346PRAMEpreferentially expressed antigen in melanomaLung+2.580.000
347GTSE1G-2 and S-phase expressed 1Lung+2.570.000
348MCM10minichromosome maintenance complex component 10Lung+2.570.000
349SPOCK1sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1Lung+2.570.000
350CRIP1cysteine-rich protein 1 (intestinal)Lung-2.570.000
351NTN4netrin 4Lung-2.570.000
352ATAD2ATPase family, AAA domain containing 2Lung+2.560.000
353IGFBP2insulin-like growth factor binding protein 2, 36kDaLung+2.560.000
354AGTR2angiotensin II receptor, type 2Lung-2.560.000
355MIR22HGMIR22 host gene (non-protein coding)Lung-2.560.000
356CDCA5cell division cycle associated 5Lung+2.560.000
357EZH2enhancer of zeste homolog 2 (Drosophila)Lung+2.560.000
358ZNF750zinc finger protein 750Lung+2.560.000
359WWC2WW and C2 domain containing 2Lung-2.550.000
360KANK3KN motif and ankyrin repeat domains 3Lung-2.550.000
361COL5A2collagen, type V, alpha 2Lung+2.550.000
362ECSCRendothelial cell surface expressed chemotaxis and apoptosis regulatorLung-2.540.000
363CYYR1cysteine/tyrosine-rich 1Lung-2.540.000
364CXCR2chemokine (C-X-C motif) receptor 2Lung-2.540.000
365BNC1basonuclin 1Lung+2.540.000
366SLC7A11solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11Lung+2.530.000
367UPK1Buroplakin 1BLung+2.530.001
368LY6Klymphocyte antigen 6 complex, locus KLung+2.520.000
369BCL11AB-cell CLL/lymphoma 11A (zinc finger protein)Lung+2.520.000
370RPL39Lribosomal protein L39-likeLung+2.510.000
371TMEM158transmembrane protein 158 (gene/pseudogene)Lung+2.500.000
372PLOD2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2Lung+2.500.000
373PTTG1pituitary tumor-transforming 1Lung+2.490.000
374TYMSthymidylate synthetaseLung+2.490.000
375SPAG5sperm associated antigen 5Lung+2.480.000
376MCM4minichromosome maintenance complex component 4Lung+2.480.000
377FGFBP1fibroblast growth factor binding protein 1Lung+2.480.000
378CHEK1checkpoint kinase 1Lung+2.470.000
379VSNL1visinin-like 1Lung+2.470.000
380PAICSphosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetaseLung+2.460.000
381NCAPGnon-SMC condensin I complex, subunit GLung+2.460.000
382COL3A1collagen, type III, alpha 1Lung+2.460.000
383APOBEC3Bapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3BLung+2.440.000
384LGR4leucine-rich repeat containing G protein-coupled receptor 4Lung+2.440.000
385CENPNcentromere protein NLung+2.440.000
386CCDC34coiled-coil domain containing 34Lung+2.430.000
387CD24CD24 moleculeLung+2.430.000
388NQO1NAD(P)H dehydrogenase, quinone 1Lung+2.420.000
389LY6Dlymphocyte antigen 6 complex, locus DLung+2.420.000
390GCLCglutamate-cysteine ligase, catalytic subunitLung+2.400.000
391EPT1ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)Lung+2.390.000
392CDC6cell division cycle 6Lung+2.390.000
393CASC5cancer susceptibility candidate 5Lung+2.390.000
394SLC16A1solute carrier family 16 (monocarboxylate transporter), member 1Lung+2.370.000
395CRABP2cellular retinoic acid binding protein 2Lung+2.360.000
396MFI2antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5Lung+2.360.000
397SLC7A5solute carrier family 7 (amino acid transporter light chain, L system), member 5Lung+2.360.000
398RHCGRh family, C glycoproteinLung+2.350.000
399HELLShelicase, lymphoid-specificLung+2.340.000
400COL12A1collagen, type XII, alpha 1Lung+2.340.000

Expression patterns in normal tissues for genes affiliated with Non-Small Cell Lung Carcinoma

Search GEO for disease gene expression data for Non-Small Cell Lung Carcinoma.

Pathways for genes affiliated with Non-Small Cell Lung Carcinoma

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Pathways related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3KRAS, EGFR
2
Show member pathways
EGFR-dependent Endothelin signaling events37
10.3EGFR, KRAS
310.3KRAS, BRAF
410.3PIK3CA, EGFR
510.3EGFR, PIK3CA
610.3BRAF, PIK3CA
710.3PIK3CA, BRAF
810.3KEAP1, PIK3CA
910.2BRAF, KRAS, EGFR
10
Show member pathways
10.2BRAF, KRAS, EGFR
11
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
10.2PIK3CA, BRAF, EGFR
1210.2PIK3CA, BRAF, EGFR
13
Show member pathways
10.2EGFR, BRAF, PIK3CA
1410.2EGFR, KRAS, PIK3CA
15
Show member pathways
10.2EGFR, KRAS, PIK3CA
16
Show member pathways
10.2EGFR, BRAF, PPP2R1B
17
Show member pathways
10.2PIK3CA, BRAF, KRAS
1810.2PIK3CA, BRAF, KRAS
19
Show member pathways
10.2PIK3CA, BRAF, KRAS
20
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway59
10.2KRAS, BRAF, PIK3CA
21
Show member pathways
10.2PPP2R1B, BRAF, KRAS
2210.2KRAS, BRAF, PPP2R1B
23
Show member pathways
Apoptosis and survival BAD phosphorylation59
Development Alpha 2 adrenergic receptor activation of ERK59
Chemotaxis CXCR4 signaling pathway59
10.2EGFR, PIK3CA, PPP2R1B
24
Show member pathways
MAPK signaling pathway37
10.1BRAF, FASLG, KRAS, EGFR
25
Show member pathways
10.1PIK3CA, BRAF, KRAS, EGFR
26
Show member pathways
10.1PIK3CA, BRAF, KRAS, EGFR
27
Show member pathways
Signaling Pathways in Glioblastoma37
10.1PIK3CA, BRAF, KRAS, EGFR
2810.1EGFR, KRAS, BRAF, PIK3CA
29
Show member pathways
10.1PIK3CA, BRAF, KRAS, EGFR
30
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
10.1PIK3CA, BRAF, KRAS, EGFR
31
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
10.1EGFR, KRAS, BRAF, PIK3CA
32
Show member pathways
10.1PIK3CA, BRAF, KRAS, EGFR
33
Show member pathways
Signal transduction PTEN pathway59
10.1PIK3CA, BRAF, KRAS, EGFR
34
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
10.1EGFR, KRAS, BRAF, PIK3CA
3510.1EGFR, KRAS, FASLG, PIK3CA
36
Show member pathways
Immune response CD16 signaling in NK cells59
10.1PIK3CA, BRAF, FASLG, KRAS
37
Show member pathways
10.1KRAS, BRAF, PIK3CA, PPP2R1B
38
Show member pathways
10.1KRAS, BRAF, PIK3CA, PPP2R1B
3910.1PIK3CA, MIR126, KRAS, EGFR
40
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
10.1PPP2R1B, PIK3CA, FASLG, KRAS
4110.1EGFR, KRAS, FASLG, BRAF, PIK3CA
4210.1EGFR, KRAS, FASLG, BRAF, PIK3CA
43
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
10.1PIK3CA, BRAF, FASLG, KRAS, EGFR
44
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
10.1PIK3CA, BRAF, FASLG, KRAS, EGFR
45
Show member pathways
10.1PIK3CA, BRAF, FASLG, KRAS, EGFR
4610.1PPP2R1B, PIK3CA, BRAF, KRAS, EGFR
47
Show member pathways
10.1PPP2R1B, PIK3CA, BRAF, KRAS, EGFR
4810.0PPP2R1B, PIK3CA, FASLG, KRAS, EGFR
49
Show member pathways
10.0PPP2R1B, PIK3CA, KRAS, KEAP1, EGFR

Compounds for genes affiliated with Non-Small Cell Lung Carcinoma

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Compounds related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1panitumumab44 50 1212.6EGFR, KRAS, BRAF
2regorafenib50 1211.6EGFR, KRAS, BRAF
3cetuximab44 50 1212.6EGFR, KRAS, BRAF
4crcs4410.6PIK3CA, BRAF, KRAS
5erlotinib44 50 1212.6EGFR, KRAS, PIK3CA
6iodide44 2511.6NKX2-1, BRAF, PIK3CA
7leucovorin44 50 1212.6EGFR, KRAS, FASLG
8ag 14784410.5PIK3CA, FASLG, EGFR
9gefitinib44 50 1212.5EGFR, KRAS, PIK3CA
105fluorouracil4410.5PIK3CA, FASLG, KRAS, EGFR
11irinotecan44 50 1212.5EGFR, KRAS, BRAF
12agar4410.5EGFR, FASLG, BRAF, PIK3CA
13imatinib44 50 1212.4PIK3CA, BRAF, FASLG, KRAS, EGFR
14paclitaxel44 50 1212.4EGFR, KRAS, FASLG, BRAF, PIK3CA
15rapamycin4410.4PIK3CA, BRAF, FASLG, KRAS, EGFR
16ly2940024410.4PIK3CA, BRAF, FASLG, KRAS, EGFR
17adpribose4410.4PIK3CA, FASLG, EGFR
18paraffin4410.4BRAF, FASLG, NKX2-1, KRAS, EGFR
19sodium iodide4410.4NKX2-1, BRAF
20cisplatin44 50 60 1213.4PIK3CA, BRAF, FASLG, KRAS, EGFR
21pd 98,0594410.3EGFR, FASLG, BRAF, PIK3CA
22o6-methylguanine4410.3KRAS, BRAF
23progesterone44 29 60 25 1214.3EGFR, NKX2-1, FASLG, BRAF, PIK3CA
24wortmannin4410.3PIK3CA, BRAF, FASLG, KRAS
25estrogen4410.3PIK3CA, BRAF, FASLG, NKX2-1, KRAS, EGFR
26retinoic acid44 2511.2PIK3CA, BRAF, FASLG, NKX2-1, KRAS, EGFR
27serine4410.1PPP2R1B, PIK3CA, BRAF, FASLG, NKX2-1, KRAS
28vegf4410.1PIK3CA, BRAF, FASLG, KRAS, EGFR
29phosphatidylinositol4410.1EGFR, KRAS, FASLG, BRAF, PIK3CA
30phosphoinositide4410.0PIK3CA, BRAF, KRAS, EGFR
31everolimus44 50 1212.0EGFR, PIK3CA

GO Terms for genes affiliated with Non-Small Cell Lung Carcinoma

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Cellular components related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:04512110.2EGFR, KRAS, PPP2R1B

Biological processes related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex cell migrationGO:02179510.4EGFR, NKX2-1
2fibroblast growth factor receptor signaling pathwayGO:00854310.3EGFR, KRAS, BRAF, PIK3CA
3Fc-epsilon receptor signaling pathwayGO:03809510.2EGFR, KRAS, PIK3CA
4neurotrophin TRK receptor signaling pathwayGO:04801110.1PIK3CA, BRAF, KRAS, EGFR
5negative regulation of neuron apoptotic processGO:04352410.1KRAS, BRAF, PIK3CA
6positive regulation of gene expressionGO:0106289.9BRAF, NKX2-1, KRAS

Molecular functions related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase kinase kinase activityGO:00470910.3EGFR, BRAF

Products for genes affiliated with Non-Small Cell Lung Carcinoma

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  • Antibodies
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Sources for Non-Small Cell Lung Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet