NSCLC
MCID: NNS005
MIFTS: 69

Non-Small Cell Lung Carcinoma (NSCLC) malady

Genetic diseases (common), Cancer diseases, Respiratory diseases categories
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Summaries for Non-Small Cell Lung Carcinoma

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Disease Ontology:8 A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.

MalaCards based summary: Non-Small Cell Lung Carcinoma, also known as nonsmall cell lung cancer, is related to lung cancer and interstitial lung disease. An important gene associated with Non-Small Cell Lung Carcinoma is EGFR (epidermal growth factor receptor), and among its related pathways are EGFR Transactivation by Gastrin and Dorso-ventral axis formation. The drugs hydroxyurea and vinorelbine and the compounds panitumumab and regorafenib have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and lymph node, and related mouse phenotypes are tumorigenesis and integument.

Wikipedia:65 Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung... more...

Description from OMIM:46 211980

Aliases & Classifications for Non-Small Cell Lung Carcinoma

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Non-Small Cell Lung Carcinoma, Aliases & Descriptions:

Name: Non-Small Cell Lung Carcinoma 30 8 10 62
Nonsmall Cell Lung Cancer 9 22 46
Non-Small Cell Lung Cancer 8 62
 
Nsclc 8 44
Carcinoma Non-Small Cell Lung 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:3908
NCIt39 C2926
SNOMED-CT57 254637007
MeSH34 D002289

Related Diseases for Non-Small Cell Lung Carcinoma

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Diseases related to Non-Small Cell Lung Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer31.2EGFR, PIK3CA, NKX2-1, KRAS
2interstitial lung disease31.0NKX2-1, EGFR
3pancreatic cancer30.8FASLG, KRAS, EGFR
4adenocarcinoma30.7EGFR, KRAS, PIK3CA, BRAF, XAGE1D, NKX2-1
5lung adenocarcinoma30.5EGFR, KRAS, XAGE1D, BRAF, PIK3CA, NKX2-1
6squamous cell carcinoma of the head and neck30.4EGFR, FASLG, PIK3CA
7ovarian cancer30.2KRAS, NKX2-1, FASLG, EGFR, BRAF, PIK3CA
8melanoma30.1BRAF, PPP2R1B, XAGE1D, PIK3CA, NKX2-1, KRAS
9glioblastoma multiforme30.1PIK3CA, EGFR, FASLG
10colorectal cancer29.7KRAS, PPP2R1B, EGFR, FASLG, PIK3CA, BRAF
11breast cancer29.2BRAF, EGFR, PPP2R1B, SLC22A18, KRAS, PIK3CA
12endotheliitis11.0
13mediastinitis10.7
14pulmonary fibrosis10.7
15idiopathic pulmonary fibrosis10.7
16retinoblastoma10.7
17lung cancer susceptibility10.6
18pulmonary blastoma10.6NKX2-1
19struma ovarii10.6NKX2-1
20thrombocytosis10.6
21pancreatitis10.6
22pneumothorax10.6
23spontaneous pneumothorax10.6
24nonsmall cell lung cancer, somatic10.5
25oligodendroglioma10.5EGFR, BRAF
26leukemia10.5
27paraneoplastic syndromes10.5
28neuroblastoma10.5
29toxic epidermal necrolysis10.5
30rhabdomyosarcoma10.5SLC22A18
31nonsmall cell lung cancer, response to tyrosine kinase inhibitor in10.4
32follicular thyroid carcinoma10.4BRAF, NKX2-1
33cardiofaciocutaneous syndrome10.4KRAS, BRAF
34chronic obstructive pulmonary disease10.4
35choroiditis10.4
36encephalitis10.4
37esophagitis10.4
38lung squamous cell carcinoma10.4
39thyroiditis10.4
40hypoxia10.4
41blindness10.4
42selection of therapeutic option in non-small cell lung carcinoma10.4
43costello syndrome10.4KRAS, BRAF
44wilms tumor10.4
45neuroendocrine carcinoma10.4
46large cell neuroendocrine carcinoma10.4
47xeroderma pigmentosum10.4
48conjunctivitis10.4
49pericardial effusion10.4
50mutagen sensitivity10.4

Graphical network of the top 20 diseases related to Non-Small Cell Lung Carcinoma:



Diseases related to non-small cell lung carcinoma

Symptoms for Non-Small Cell Lung Carcinoma

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Clinical features from OMIM:

211980

Drugs & Therapeutics for Non-Small Cell Lung Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Non-Small Cell Lung Carcinoma

Search NIH Clinical Center for Non-Small Cell Lung Carcinoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Non-Small Cell Lung Carcinoma

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Genetic tests related to Non-Small Cell Lung Carcinoma:

id Genetic test Affiliating Genes
1 Non-Small Cell Lung Cancer22

Anatomical Context for Non-Small Cell Lung Carcinoma

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MalaCards organs/tissues related to Non-Small Cell Lung Carcinoma:

32
Lung, Endothelial, Lymph node, Brain, Bone, Testes, Testis, T cells, Kidney, Thyroid, Bronchial epithelium, Bone marrow, Liver, Breast, Prostate, B cells, Pituitary, Neutrophil

Animal Models for Non-Small Cell Lung Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Non-Small Cell Lung Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.0PIK3CA, BRAF, FASLG, NKX2-1, KRAS, EGFR
2MP:001077110.0PIK3CA, BRAF, KRAS, KEAP1, EGFR, FASLG
3MP:00053889.9KEAP1, KRAS, NKX2-1, FASLG, BRAF, EGFR
4MP:00053819.8BRAF, EGFR, KEAP1, KRAS, NKX2-1, FASLG
5MP:00053799.7KRAS, NKX2-1, FASLG, BRAF, PIK3CA, EGFR

Publications for Non-Small Cell Lung Carcinoma

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Articles related to Non-Small Cell Lung Carcinoma:

(show top 50)    (show all 772)
idTitleAuthorsYear
1
Inonotus obliquus-derived polysaccharide inhibits the migration and invasion of human non-small cell lung carcinoma cells via suppression of MMP-2 and MMP-9. (25270791)
2014
2
Outcomes Treating Stage Iii Non-Small Cell Lung Carcinoma with Curative-Intent Radiotherapy and Concurrent Carboplatin-Paclitaxel Chemotherapy. (25353367)
2014
3
Long-term survival after surgical treatment of metachronous bilateral adrenal metastases of non-small cell lung carcinoma. (25317919)
2014
4
CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. (23877438)
2013
5
Radical treatment of synchronous oligometastatic non-small cell lung carcinoma (NSCLC): patient outcomes and prognostic factors. (23973202)
2013
6
Level of plasmacytoid dendritic cells is increased in non-small cell lung carcinoma. (24136746)
2013
7
Additional weekly Cetuximab to concurrent chemoradiotherapy in locally advanced non-small cell lung carcinoma: Efficacy and safety outcomes of a randomized, multi-center phase II study investigating. (24225233)
2013
8
ROS1 receptor tyrosine kinase, a druggable target, is frequently overexpressed in non-small cell lung carcinomas via genetic and epigenetic mechanisms. (22915320)
2013
9
Therapeutic strategy for advanced EGFR mutant non-small-cell lung carcinoma. (23911281)
2013
10
Utilization of p40 (I9Np63) with p63 and cytokeratin 5/6 immunohistochemistry in non-small cell lung carcinoma fine-needle aspiration biopsy. (24107322)
2013
11
Concomitant EGFR inhibitors combined with radiation for treatment of non-small cell lung carcinoma. (24083690)
2013
12
Non-small-cell lung carcinoma subtyping on cytology without the use of immunohistochemistry - can we meet the challenge? (22846184)
2012
13
Evaluation of carboplatin dosing in non-small cell lung carcinoma patients using Calvert formula and Cockroft and Gault equation for glomerular filtration rate estimation. (23162654)
2012
14
Higher expression of EphA2 and ephrin-A1 is related to favorable clinicopathological features in pathological stage I non-small cell lung carcinoma. (22236865)
2012
15
Disseminated herpes simplex virus infection following epidermal growth factor tyrosine kinase inhibitor therapy for non-small-cell lung carcinoma. (23157525)
2012
16
Synergistic antitumor effect of I^-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells. (21904777)
2011
17
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma. (21878121)
2011
18
Multiple myeloma emerging after prolonged gefitinib treatment for non-small cell lung carcinoma. (21516269)
2011
19
The prognostic value of intraepithelial and stromal CD3-, CD117- and CD138-positive cells in non-small cell lung carcinoma. (20477813)
2010
20
CYFRA21-1 can predict the sensitivity to chemoradiotherapy of non-small-cell lung carcinoma. (20649505)
2010
21
Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach. (20068099)
2010
22
Gefitinib in combination with gemcitabine and carboplatin in never smokers with non-small cell lung carcinoma: a retrospective analysis. (19546820)
2009
23
Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor. (19509246)
2009
24
The efficiency of single agent docetaxel in patients with platinum-refractory non-small cell lung carcinoma. (18320363)
2008
25
Co-expression patterns of tumor-associated antigen genes by non-small cell lung carcinomas: implications for immunotherapy. (18094614)
2008
26
Multi-arterial infusion chemotherapy for non-small cell lung carcinoma--significance of detecting feeding arteries and tumor staining. (18243405)
2008
27
Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report. (18700972)
2008
28
EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. (18242762)
2008
29
MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. (18602365)
2008
30
Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma. (17541031)
2007
31
Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma. (17545606)
2007
32
High frequency of p16 promoter methylation in non-small cell lung carcinomas from Chile. (18449464)
2007
33
Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma. (17299390)
2007
34
Lung tissue and tumour-infiltrating T lymphocytes in patients with non-small cell lung carcinoma and chronic obstructive pulmonary disease (COPD): moderate/severe versus mild stage of COPD. (17949407)
2007
35
Clinical and prognostic significance of podoplanin-positive lymphatic vessel density in non-small cell lung carcinoma]. (17327058)
2006
36
Time delay and its effect on survival in malaysian patients with non-small cell lung carcinoma. (22589589)
2006
37
Long-term outcome after resection of non-small cell lung carcinoma complicated by pneumoconiosis. (16998679)
2006
38
A case of recurrent non-small-cell lung carcinoma and paraneoplastic Cushing's syndrome. (16352372)
2006
39
Interleukin-8 in non-small cell lung carcinoma: relation with angiogenic pattern and p53 alterations. (16125276)
2005
40
Preclinical anti-tumor activity of XR5944 in combination with carboplatin or doxorubicin in non-small-cell lung carcinoma. (16162971)
2005
41
The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. (12819188)
2003
42
Expression of vascular endothelial growth factor mRNA in non-small-cell lung carcinomas. (9888482)
1999
43
Expression of vascular endothelial growth factor (VEGF) and its two receptors (VEGF-R1-Flt1 and VEGF-R2-Flk1/KDR) in non-small cell lung carcinomas (NSCLCs): correlation with angiogenesis and survival. (10440746)
1999
44
Prognostic value of basic fibroblast growth factor and its receptor (FGFR-1) in patients with non-small cell lung carcinomas. (9274456)
1997
45
Recurrence and death in non-small cell lung carcinomas: a prognostic model using pathological parameters, microvessel count, and gene protein products. (9816269)
1996
46
Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance. (8957065)
1996
47
Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma. (7606711)
1995
48
bcl-2 protein in non-small-cell lung carcinoma. (8264763)
1994
49
Overexpression of oncoproteins in non-small cell lung carcinomas of smokers. (8389672)
1993
50
Elevated expression of thymidylate synthase in doxorubicin resistant human non small cell lung carcinomas. (1338282)
1992

Variations for Non-Small Cell Lung Carcinoma

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UniProtKB/Swiss-Prot genetic disease variations for Non-Small Cell Lung Carcinoma:

64
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Clinvar genetic disease variations for Non-Small Cell Lung Carcinoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> T (p.Gly12Cys)single nucleotide variantPathogenicrs121913530GRCh37Chr 12, 25398285: 25398285
2PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
3PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
4BRAFNM_004333.4(BRAF): c.1789C> G (p.Leu597Val)single nucleotide variantPathogenicrs121913369GRCh37Chr 7, 140453146: 140453146
5FASLGNM_000639.1(FASLG): c.-844C=single nucleotide variantPathogenicrs763110GRCh37Chr 1, 172627498: 172627498
6PPP2R1BNM_181699.2(PPP2R1B): c.269G> A (p.Gly90Asp)single nucleotide variantPathogenicrs1805076GRCh37Chr 11, 111635566: 111635566
7SLC22A18NM_183233.2(SLC22A18): c.698C> T (p.Ser233Phe)single nucleotide variantPathogenicrs121909071GRCh37Chr 11, 2939260: 2939260

Expression for genes affiliated with Non-Small Cell Lung Carcinoma

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Expression patterns in normal tissues for genes affiliated with Non-Small Cell Lung Carcinoma

Search GEO for disease gene expression data for Non-Small Cell Lung Carcinoma.

Pathways for genes affiliated with Non-Small Cell Lung Carcinoma

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Pathways related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
EGFR-dependent Endothelin signaling events37
10.3KRAS, EGFR
210.3EGFR, KRAS
310.3KRAS, BRAF
410.3PIK3CA, EGFR
510.3EGFR, PIK3CA
610.3BRAF, PIK3CA
710.3BRAF, PIK3CA
810.3KEAP1, PIK3CA
9
Show member pathways
10.2BRAF, KRAS, EGFR
1010.2KRAS, BRAF, EGFR
11
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
10.2EGFR, PIK3CA, BRAF
12
Show member pathways
10.2EGFR, BRAF, PIK3CA
1310.2EGFR, BRAF, PIK3CA
14
Show member pathways
10.2PIK3CA, KRAS, EGFR
1510.2PIK3CA, KRAS, EGFR
16
Show member pathways
10.2PPP2R1B, BRAF, EGFR
17
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
10.2KRAS, PIK3CA, BRAF
18
Show member pathways
10.2PIK3CA, BRAF, KRAS
1910.2KRAS, BRAF, PIK3CA
20
Show member pathways
10.2KRAS, BRAF, PIK3CA
2110.2PPP2R1B, KRAS, BRAF
22
Show member pathways
10.2PPP2R1B, KRAS, BRAF
23
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
10.2EGFR, PIK3CA, PPP2R1B
24
Show member pathways
MAPK signaling pathway37
10.1FASLG, EGFR, KRAS, BRAF
25
Show member pathways
10.1BRAF, KRAS, EGFR, PIK3CA
26
Show member pathways
10.1KRAS, EGFR, BRAF, PIK3CA
27
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
10.1PIK3CA, KRAS, BRAF, EGFR
28
Show member pathways
10.1PIK3CA, EGFR, KRAS, BRAF
29
Show member pathways
Signaling Pathways in Glioblastoma37
10.1PIK3CA, BRAF, KRAS, EGFR
3010.1EGFR, KRAS, BRAF, PIK3CA
31
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
10.1EGFR, KRAS, BRAF, PIK3CA
32
Show member pathways
10.1KRAS, PIK3CA, EGFR, BRAF
33
Show member pathways
Signal transduction PTEN pathway60
10.1PIK3CA, BRAF, EGFR, KRAS
34
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
10.1EGFR, BRAF, PIK3CA, KRAS
3510.1EGFR, PIK3CA, FASLG, KRAS
36
Show member pathways
Immune response CD16 signaling in NK cells60
10.1KRAS, BRAF, PIK3CA, FASLG
37
Show member pathways
10.1PIK3CA, PPP2R1B, KRAS, BRAF
38
Show member pathways
10.1BRAF, PPP2R1B, KRAS, PIK3CA
3910.1MIR126, EGFR, PIK3CA, KRAS
40
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
10.1KRAS, PPP2R1B, PIK3CA, FASLG
41
Show member pathways
10.1BRAF, PIK3CA, EGFR, KRAS, FASLG
42
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
10.1EGFR, KRAS, FASLG, BRAF, PIK3CA
4310.1BRAF, KRAS, FASLG, PIK3CA, EGFR
44
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
10.1BRAF, FASLG, KRAS, EGFR, PIK3CA
4510.1EGFR, PIK3CA, FASLG, BRAF, KRAS
4610.1PPP2R1B, BRAF, PIK3CA, KRAS, EGFR
47
Show member pathways
10.1EGFR, PPP2R1B, PIK3CA, BRAF, KRAS
4810.0PIK3CA, KRAS, PPP2R1B, EGFR, FASLG
49
Show member pathways
10.0PPP2R1B, PIK3CA, KRAS, KEAP1, EGFR

Compounds for genes affiliated with Non-Small Cell Lung Carcinoma

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Compounds related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1panitumumab44 50 1112.6EGFR, BRAF, KRAS
2regorafenib50 1111.6KRAS, BRAF, EGFR
3cetuximab44 50 1112.6BRAF, KRAS, EGFR
4crcs4410.6KRAS, BRAF, PIK3CA
5erlotinib44 50 1112.6PIK3CA, KRAS, EGFR
6iodide44 2411.6PIK3CA, NKX2-1, BRAF
7leucovorin44 50 1112.6KRAS, EGFR, FASLG
8ag 14784410.5FASLG, EGFR, PIK3CA
9gefitinib44 50 1112.5KRAS, EGFR, PIK3CA
105fluorouracil4410.5EGFR, KRAS, FASLG, PIK3CA
11irinotecan44 50 1112.5EGFR, KRAS, BRAF
12agar4410.5FASLG, PIK3CA, EGFR, BRAF
13imatinib44 50 1112.4BRAF, FASLG, PIK3CA, EGFR, KRAS
14paclitaxel44 50 1112.4KRAS, EGFR, BRAF, FASLG, PIK3CA
15rapamycin4410.4FASLG, BRAF, EGFR, KRAS, PIK3CA
16ly2940024410.4FASLG, PIK3CA, KRAS, EGFR, BRAF
17adpribose4410.4EGFR, FASLG, PIK3CA
18paraffin4410.4FASLG, KRAS, EGFR, NKX2-1, BRAF
19sodium iodide4410.4BRAF, NKX2-1
20cisplatin44 50 61 1113.4KRAS, FASLG, BRAF, PIK3CA, EGFR
21pd 98,0594410.3FASLG, PIK3CA, BRAF, EGFR
22o6-methylguanine4410.3KRAS, BRAF
23progesterone44 28 61 24 1114.3EGFR, NKX2-1, FASLG, BRAF, PIK3CA
24wortmannin4410.3BRAF, FASLG, KRAS, PIK3CA
25estrogen4410.3KRAS, FASLG, NKX2-1, BRAF, PIK3CA, EGFR
26retinoic acid44 2411.2PIK3CA, FASLG, NKX2-1, KRAS, BRAF, EGFR
27serine4410.1PPP2R1B, EGFR, KRAS, NKX2-1, PIK3CA, BRAF
28vegf4410.1BRAF, FASLG, KRAS, EGFR, PIK3CA
29phosphatidylinositol4410.1FASLG, KRAS, EGFR, PIK3CA, BRAF
30phosphoinositide4410.0BRAF, PIK3CA, KRAS, EGFR
31everolimus44 50 1112.0EGFR, PIK3CA

GO Terms for genes affiliated with Non-Small Cell Lung Carcinoma

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Cellular components related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:04512110.2EGFR, KRAS, PPP2R1B

Biological processes related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex cell migrationGO:02179510.4EGFR, NKX2-1
2fibroblast growth factor receptor signaling pathwayGO:00854310.3EGFR, KRAS, BRAF, PIK3CA
3Fc-epsilon receptor signaling pathwayGO:03809510.2KRAS, PIK3CA, EGFR
4neurotrophin TRK receptor signaling pathwayGO:04801110.1BRAF, KRAS, EGFR, PIK3CA
5negative regulation of neuron apoptotic processGO:04352410.1KRAS, BRAF, PIK3CA
6positive regulation of gene expressionGO:0106289.9BRAF, NKX2-1, KRAS

Molecular functions related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase kinase kinase activityGO:00470910.3EGFR, BRAF

Products for genes affiliated with Non-Small Cell Lung Carcinoma

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Sources for Non-Small Cell Lung Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet