NSCLC
MCID: NNS005
MIFTS: 58

Non-Small Cell Lung Carcinoma (NSCLC) malady

Respiratory diseases, Cancer diseases categories

Summaries for Non-Small Cell Lung Carcinoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung... more...

MalaCards: Non-Small Cell Lung Carcinoma, also known as nonsmall cell lung cancer, is related to colorectal cancer and lung adenocarcinoma. An important gene associated with Non-Small Cell Lung Carcinoma is EGFR (epidermal growth factor receptor), and among its related pathways are Development HGF signaling pathway and G-Beta Gamma Signaling. The drugs hydroxyurea and vinorelbine and the compounds panitumumab and cetuximab have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and lymph node, and related mouse phenotype pigmentation.

Description from OMIM:46 211980

Aliases & Classifications for Non-Small Cell Lung Carcinoma

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 9diseasecard, 22GTR, 46OMIM, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

non-small cell lung carcinoma 8 10 60
nonsmall cell lung cancer 9 22 46
nsclc 8 44
carcinoma non-small cell lung 44
non-small cell lung cancer 8


External Ids:

Disease Ontology8 DOID:3908
MeSH34 D002289
SNOMED-CT56 254637007
NCIt39 C2926

Related Diseases for Non-Small Cell Lung Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Non-Small Cell Lung Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer31.1BRAF, EGFR
2lung adenocarcinoma30.8EGFR, BRAF
3ovarian cancer30.5BRAF, EGFR
4colon cancer30.3EGFR, BRAF
5small cell carcinoma11.7
6lung small cell carcinoma11.7
7lung cancer10.9
8thoracic cancer10.8
9esophageal cancer10.8
10lung squamous cell carcinoma10.7
11squamous cell carcinoma10.7
12mediastinitis10.7
13pulmonary fibrosis10.7
14idiopathic pulmonary fibrosis10.6
15lung carcinoma in situ10.6
16in situ carcinoma10.6
17retinoblastoma10.6
18bone carcinoma10.6
19adrenal carcinoma10.6
20adenocarcinoma10.6
21thrombocytosis10.5
22melanoma10.5
23pancreatic cancer10.5
24pancreatitis10.5
25pneumothorax10.5
26nonsmall cell lung cancer, somatic10.5
27neuroendocrine carcinoma10.5
28lung superior sulcus carcinoma10.5
29gastric small cell carcinoma10.5
30lung occult small cell carcinoma10.5
31leukemia10.5
32transitional cell carcinoma10.5
33neuroblastoma10.5
34nonsmall cell lung cancer, response to tyrosine kinase inhibitor in10.4
35parathyroid carcinoma10.4
36lung lymphoma10.4
37large cell carcinoma10.4
38encephalitis10.4
39esophagitis10.4
40lung large cell carcinoma10.4
41obstructive lung disease10.4
42thyroiditis10.4
43central nervous system cancer10.4
44conjunctivitis10.4
45nervous system cancer10.4
46pericardial effusion10.4
47prostate cancer10.4
48small intestine cancer10.4
49spinal cancer10.4
50non-small cell lung cancer, childhood10.4

Graphical network of the top 20 diseases related to Non-Small Cell Lung Carcinoma:



Diseases related to non-small cell lung carcinoma

Clinical Features for Non-Small Cell Lung Carcinoma

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Sources:
46OMIM
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Clinical features from OMIM:

211980

Drugs & Therapeutics for Non-Small Cell Lung Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Non-Small Cell Lung Carcinoma

Drug clinical trials:

Search ClinicalTrials for Non-Small Cell Lung Carcinoma

Search NIH Clinical Center for Non-Small Cell Lung Carcinoma

Search CenterWatch for Non-Small Cell Lung Carcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Non-Small Cell Lung Carcinoma

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22GTR
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Genetic tests related to Non-Small Cell Lung Carcinoma:

id Genetic test Affiliating Genes
1 Non-Small Cell Lung Cancer22

Anatomical Context for Non-Small Cell Lung Carcinoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Non-Small Cell Lung Carcinoma:

32
Lung, Endothelial, Lymph node, Brain, Bone, Testes, T cells, Testis, Thyroid, Prostate, Breast, Bronchial epithelium, Kidney, Liver, B cells, Bone marrow, Pituitary

Animal Models for Non-Small Cell Lung Carcinoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Non-Small Cell Lung Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.1EGFR, BRAF

Publications for Non-Small Cell Lung Carcinoma

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Sources:
50PubMed
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Articles related to Non-Small Cell Lung Carcinoma:

(show top 50)    (show all 829)
idTitleAuthorsYear
1
Pharmacokinetic and pharmacodynamic study of Gefitinib in a mouse model of non-small-cell lung carcinoma with brain metastasis. (24011632)
2013
2
Expression of adiponectin receptor 1 is indicative of favorable prognosis in non-small cell lung carcinoma. (23358237)
2013
3
Recurrent inactivating mutations of ARID2 in non-small cell lung carcinoma. (23047306)
2013
4
Autophagy and Bcl-2/BNIP3 death regulatory pathway in non-small cell lung carcinomas. (23216071)
2013
5
EGFR mutation status in brain metastases of non-small cell lung carcinoma. (23086434)
2013
6
Gene Expression Profile of the A549 Human Non-Small Cell Lung Carcinoma Cell Line following Treatment with the Seeds of Descurainia sophia, a Potential Anticancer Drug. (23935669)
2013
7
Baseline and post-surgery endothelial progenitor cell levels in patients with early-stage non-small-cell lung carcinoma: impact on cancer recurrence and survival. (23882070)
2013
8
EURTAC first line therapy for non small cell lung carcinoma in epidermal growth factor receptor mutation positive patients: A choice between two TKIs. (22833833)
2012
9
STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma. (22319590)
2012
10
Tumour heterogeneity in non-small cell lung carcinoma assessed by CT texture analysis: a potential marker of survival. (22086561)
2012
11
Immunohistochemical evaluation of inhibin-alpha in non-small-cell lung carcinomas--a pitfall in diagnosing metastatic pulmonary carcinomas. (22585605)
2012
12
Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma. (20434789)
2011
13
Induction of apoptosis by 15d-PGJ2 via ROS formation: an alternative pathway without PPARI^ activation in non-small cell lung carcinoma A549 cells. (21396480)
2011
14
Detection of epidermal growth factor receptor mutations in non-small-cell lung carcinoma by direct sequencing and correlations with clinicopathological characteristics and sample types]. (22321541)
2011
15
EGFR mutation is a better predictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry. (20472851)
2010
16
Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women. (20802022)
2010
17
Consumption of S-Allylcysteine Inhibits the Growth of Human Non-Small-Cell Lung Carcinoma in a Mouse Xenograft Model. (20866043)
2010
18
Non-small cell lung carcinoma of the superior sulcus: The evolution of treatment outcomes with multimodality treatment at a single institution. (20191604)
2010
19
Utility of plasma tumour necrosis factor-alpha and transforming growth factor-beta1 as predictors of survival and treatment outcome in advanced non-small cell lung carcinoma. (20486867)
2010
20
Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata mycelia are mediated by down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell. (19995598)
2010
21
Refining the diagnosis and EGFR status of non-small cell lung carcinoma in biopsy and cytologic material, using a panel of mucin staining, TTF-1, cytokeratin 5/6, and P63, and EGFR mutation analysis. (20068475)
2010
22
Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non-small cell lung carcinomas. (19386350)
2009
23
The prognostic value of intraepithelial and stromal innate immune system cells in non-small cell lung carcinoma. (19723145)
2009
24
Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report. (18700972)
2008
25
Differential sensitivity of A549 non-small lung carcinoma cell responses to epidermal growth factor receptor pathway inhibitors. (18296914)
2008
26
The prognostic value of carcinoembryonic antigen in T1N1M0 and T2N1M0 non-small cell carcinoma of the lung. (17643308)
2007
27
Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma. (17299390)
2007
28
Simultaneous expression of c-erbB-1, c-erbB-2, c-erbB-3 and c-erbB-4 receptors in non-small-cell lung carcinomas: correlation with clinical outcome. (17442448)
2007
29
Association of CD133 and endothelin-converting enzyme expressions with prognosis of non-small cell lung carcinoma]. (17545092)
2007
30
Gefitinib and high-dose fractionated radiotherapy for carcinomatous encephalitis from non-small cell lung carcinoma. (19707341)
2007
31
ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis. (16052521)
2006
32
Interstitial lung disease associated with epidermal growth factor receptor tyrosine kinase inhibitor therapy in non-small-cell lung carcinoma. (17239288)
2006
33
Clinicopathological significance of BGP expression in non-small-cell lung carcinoma: relationship with histological type, microvessel density and patients' survival. (17393985)
2006
34
Bullous dermatosis associated with gemcitabine therapy for non-small-cell lung carcinoma. (16434173)
2006
35
Toxicity and outcome results of RTOG 9311: a phase I-II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small-cell lung carcinoma. (15667949)
2005
36
Expression of endothelin-1 is related to poor prognosis in non-small cell lung carcinoma. (16298124)
2005
37
Advanced age does not exclude lobectomy for non-small cell lung carcinoma. (16236941)
2005
38
ED-B fibronectin in non-small cell lung carcinoma. (16203624)
2005
39
The role of FDG-PET in the management of non-small cell lung carcinoma. (15098629)
2004
40
Sealing of the mediastinum with a local hemostyptic agent reduces chest tube duration after complete mediastinal lymph node dissection for stage I and II non-small cell lung carcinoma. (14992920)
2004
41
Transcriptional activity of surfactant-apoproteins A1 and A2 in non small cell lung carcinomas and tumor-free lung tissues]. (15216431)
2004
42
The role of epidermal growth factor receptor in advanced non-small cell lung carcinoma. (14649327)
2003
43
Deregulated expression of c-mos in non-small cell lung carcinomas: relationship with p53 status, genomic instability, and tumor kinetics. (11212247)
2001
44
Alterations of p14ARF, p53, and p73 genes involved in the E2F-1-mediated apoptotic pathways in non-small cell lung carcinoma. (11454718)
2001
45
Evaluations of p53 immunoreactivity, nucleolar organizer regions, and proliferating cell nuclear antigen in non-small cell lung carcinoma. (10769714)
2000
46
A review of ifosfamide and vinorelbine in advanced non-small cell carcinoma of the lung. (9535205)
1998
47
Epidermal growth factor receptors and their ligands in non-small-cell lung carcinoma]. (9662999)
1998
48
Detection of occult micrometastases in non-small cell lung carcinoma by reverse transcriptase-polymerase chain reaction. (9631789)
1998
49
Effects of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonists on the growth of human small-cell and non-small-cell lung carcinomas in nude mice. (7947094)
1994
50
Proto-oncogene and growth factor/receptor expression in the establishment of primary human non-small cell lung carcinoma cell lines. (8382008)
1993

Genetic Variations for Non-Small Cell Lung Carcinoma

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Non-Small Cell Lung Carcinoma:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Expression for genes affiliated with Non-Small Cell Lung Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Non-Small Cell Lung Carcinoma

Search GEO for disease gene expression data for Non-Small Cell Lung Carcinoma.

Pathways for genes affiliated with Non-Small Cell Lung Carcinoma

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Sources:
12EMD Millipore, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 59Tocris Bioscience, 49PharmGKB
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Pathways related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1EGFR, BRAF
2
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9.1EGFR, BRAF
3
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9.1EGFR, BRAF
49.1BRAF, EGFR
5
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9.1EGFR, BRAF
6
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9.1EGFR, BRAF
7
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9.1BRAF, EGFR
8
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9.1EGFR, BRAF
9
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9.1EGFR, BRAF
10
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9.1EGFR, BRAF
119.1EGFR, BRAF
12
Hide members
9.1BRAF, EGFR
13
Translation Insulin regulation of translation
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9.1EGFR, BRAF
14
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9.1EGFR, BRAF
15
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9.1EGFR, BRAF
16
Hide members
9.1BRAF, EGFR
179.1EGFR, BRAF
18
Hide members
9.1EGFR, BRAF
199.1EGFR, BRAF
20
Hide members
9.1BRAF, EGFR
219.1EGFR, BRAF
22
Hide members
9.1EGFR, BRAF
239.1BRAF, EGFR
24
Hide members
9.1EGFR, BRAF
259.1EGFR, BRAF
26
Hide members
9.1EGFR, BRAF
279.1EGFR, BRAF
289.1BRAF, EGFR
29
Hide members
9.1EGFR, BRAF
30
Hide members
9.1EGFR, BRAF
319.1EGFR, BRAF

Compounds for genes affiliated with Non-Small Cell Lung Carcinoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1panitumumab44 49 1111.4EGFR, BRAF
2cetuximab44 49 1111.4EGFR, BRAF
3sorafenib44 49 1111.4EGFR, BRAF
4irinotecan44 49 1111.4BRAF, EGFR
5geldanamycin44 49 59 1112.4EGFR, BRAF
6imatinib44 49 1111.4EGFR, BRAF
7agar449.3EGFR, BRAF
8sb 20358044 5910.3BRAF, EGFR
9paclitaxel44 49 1111.3EGFR, BRAF
10rapamycin449.2EGFR, BRAF
11pd 98,059449.2EGFR, BRAF
12ly294002449.1BRAF, EGFR
13cisplatin44 49 59 1112.1EGFR, BRAF
14phosphoinositide449.0EGFR, BRAF
15paraffin448.8EGFR, BRAF

GO Terms for genes affiliated with Non-Small Cell Lung Carcinoma

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16Gene Ontology
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Biological processes related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:0001869.1EGFR, BRAF
2neurotrophin TRK receptor signaling pathwayGO:0480119.1EGFR, BRAF
3positive regulation of ERK1 and ERK2 cascadeGO:0703749.0EGFR, BRAF
4fibroblast growth factor receptor signaling pathwayGO:0085438.8EGFR, BRAF

Molecular functions related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1EGFR, BRAF

Products for genes affiliated with Non-Small Cell Lung Carcinoma

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  • Antibodies
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  • Antibodies

Sources for Non-Small Cell Lung Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet