NSCLC
MCID: NNS005
MIFTS: 58

Non-Small Cell Lung Carcinoma (NSCLC) malady

Genetic diseases (common), Cancer diseases, Respiratory diseases categories

Summaries for Non-Small Cell Lung Carcinoma

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung... more...

MalaCards: Non-Small Cell Lung Carcinoma, also known as nonsmall cell lung cancer, is related to lung cancer and interstitial lung disease. An important gene associated with Non-Small Cell Lung Carcinoma is EGFR (epidermal growth factor receptor), and among its related pathways are G protein signaling K RAS regulation pathway and Development EGFR signaling pathway. The drugs hydroxyurea and vinorelbine and the compounds panitumumab and cetuximab have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and lymph node.

Description from OMIM:48 211980

Aliases & Classifications for Non-Small Cell Lung Carcinoma

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 46Novoseek, 10diseasecard, 23GTR, 48OMIM, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

non-small cell lung carcinoma 9 11 63
nonsmall cell lung cancer 10 23 48
nsclc 9 46
carcinoma non-small cell lung 46
non-small cell lung cancer 9


External Ids:

Disease Ontology9 DOID:3908
NCIt41 C2926
SNOMED-CT59 254637007
MeSH36 D002289

Related Diseases for Non-Small Cell Lung Carcinoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Non-Small Cell Lung Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer31.1BRAF, XAGE1D, NKX2-1, KEAP1, EGFR
2interstitial lung disease30.5EGFR, NKX2-1
3lung adenocarcinoma30.3BRAF, XAGE1D, NKX2-1, EGFR
4endotheliitis11.0
5mediastinitis10.7
6pulmonary fibrosis10.7
7idiopathic pulmonary fibrosis10.7
8colorectal cancer10.7
9retinoblastoma10.6
10adenocarcinoma10.6
11thrombocytosis10.5
12melanoma10.5
13pancreatitis10.5
14pneumothorax10.5
15spontaneous pneumothorax10.5
16lung cancer susceptibility10.5
17nonsmall cell lung cancer, somatic10.5
18leukemia10.5
19paraneoplastic syndromes10.5
20neuroblastoma10.5
21toxic epidermal necrolysis10.5
22nonsmall cell lung cancer, response to tyrosine kinase inhibitor in10.4
23bronchogenic carcinoma10.4
24encephalitis10.4
25esophagitis10.4
26thyroiditis10.4
27hypoxia10.4
28blindness10.4
29neuroendocrine carcinoma10.4
30large cell neuroendocrine carcinoma10.4
31conjunctivitis10.4
32pancreatic cancer10.4
33pericardial effusion10.4
34wilms tumor10.4
35mutagen sensitivity10.4
36non-small cell lung cancer, childhood10.4
37thromboembolism10.4
38venous thromboembolism10.4
39leukopenia10.4
40pharyngitis10.3
41hypogonadism10.3
42mononeuritis multiplex10.3
43membranous glomerulonephritis10.3
44lung giant cell carcinoma10.3
45choroiditis10.3
46cushing's syndrome10.3
47pulmonary sclerosing hemangioma10.3
48pancytopenia10.3
49chronic lymphocytic leukemia10.3
50diabetes mellitus10.3

Graphical network of the top 20 diseases related to Non-Small Cell Lung Carcinoma:



Diseases related to non-small cell lung carcinoma

Symptoms for Non-Small Cell Lung Carcinoma

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Sources:
48OMIM
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Clinical features from OMIM:

211980

Drugs & Therapeutics for Non-Small Cell Lung Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Non-Small Cell Lung Carcinoma

Drug clinical trials:

Search ClinicalTrials for Non-Small Cell Lung Carcinoma

Search NIH Clinical Center for Non-Small Cell Lung Carcinoma

Search CenterWatch for Non-Small Cell Lung Carcinoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Non-Small Cell Lung Carcinoma

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23GTR
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Genetic tests related to Non-Small Cell Lung Carcinoma:

id Genetic test Affiliating Genes
1 Non-Small Cell Lung Cancer23

Anatomical Context for Non-Small Cell Lung Carcinoma

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Sources:
34MalaCards
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MalaCards organs/tissues related to Non-Small Cell Lung Carcinoma:

34
Lung, Endothelial, Lymph node, Brain, Bone, Testes, T cells, Testis, Breast, Thyroid, Kidney, B cells, Prostate, Bronchial epithelium, Liver, Bone marrow, Pituitary

Animal Models for Non-Small Cell Lung Carcinoma or affiliated genes

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Publications for Non-Small Cell Lung Carcinoma

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Sources:
53PubMed
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Articles related to Non-Small Cell Lung Carcinoma:

(show top 50)    (show all 755)
idTitleAuthorsYear
1
CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. (23877438)
2013
2
Radical treatment of synchronous oligometastatic non-small cell lung carcinoma (NSCLC): patient outcomes and prognostic factors. (23973202)
2013
3
Knockdown of copper chaperone antioxidant-1 by RNA interference inhibits copper-stimulated proliferation of non-small cell lung carcinoma cells. (23624903)
2013
4
Level of plasmacytoid dendritic cells is increased in non-small cell lung carcinoma. (24136746)
2013
5
Additional weekly Cetuximab to concurrent chemoradiotherapy in locally advanced non-small cell lung carcinoma: Efficacy and safety outcomes of a randomized, multi-center phase II study investigating. (24225233)
2013
6
ROS1 receptor tyrosine kinase, a druggable target, is frequently overexpressed in non-small cell lung carcinomas via genetic and epigenetic mechanisms. (22915320)
2013
7
Therapeutic strategy for advanced EGFR mutant non-small-cell lung carcinoma. (23911281)
2013
8
Utilization of p40 (I9Np63) with p63 and cytokeratin 5/6 immunohistochemistry in non-small cell lung carcinoma fine-needle aspiration biopsy. (24107322)
2013
9
Concomitant EGFR inhibitors combined with radiation for treatment of non-small cell lung carcinoma. (24083690)
2013
10
Non-small-cell lung carcinoma subtyping on cytology without the use of immunohistochemistry - can we meet the challenge? (22846184)
2012
11
Evaluation of carboplatin dosing in non-small cell lung carcinoma patients using Calvert formula and Cockroft and Gault equation for glomerular filtration rate estimation. (23162654)
2012
12
Higher expression of EphA2 and ephrin-A1 is related to favorable clinicopathological features in pathological stage I non-small cell lung carcinoma. (22236865)
2012
13
Disseminated herpes simplex virus infection following epidermal growth factor tyrosine kinase inhibitor therapy for non-small-cell lung carcinoma. (23157525)
2012
14
Synergistic antitumor effect of I^-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells. (21904777)
2011
15
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma. (21878121)
2011
16
Multiple myeloma emerging after prolonged gefitinib treatment for non-small cell lung carcinoma. (21516269)
2011
17
The prognostic value of intraepithelial and stromal CD3-, CD117- and CD138-positive cells in non-small cell lung carcinoma. (20477813)
2010
18
CYFRA21-1 can predict the sensitivity to chemoradiotherapy of non-small-cell lung carcinoma. (20649505)
2010
19
Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach. (20068099)
2010
20
Gefitinib in combination with gemcitabine and carboplatin in never smokers with non-small cell lung carcinoma: a retrospective analysis. (19546820)
2009
21
Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor. (19509246)
2009
22
The efficiency of single agent docetaxel in patients with platinum-refractory non-small cell lung carcinoma. (18320363)
2008
23
Co-expression patterns of tumor-associated antigen genes by non-small cell lung carcinomas: implications for immunotherapy. (18094614)
2008
24
Multi-arterial infusion chemotherapy for non-small cell lung carcinoma--significance of detecting feeding arteries and tumor staining. (18243405)
2008
25
Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report. (18700972)
2008
26
EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. (18242762)
2008
27
MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. (18602365)
2008
28
Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma. (17541031)
2007
29
Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma. (17545606)
2007
30
High frequency of p16 promoter methylation in non-small cell lung carcinomas from Chile. (18449464)
2007
31
Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma. (17299390)
2007
32
Lung tissue and tumour-infiltrating T lymphocytes in patients with non-small cell lung carcinoma and chronic obstructive pulmonary disease (COPD): moderate/severe versus mild stage of COPD. (17949407)
2007
33
Clinical and prognostic significance of podoplanin-positive lymphatic vessel density in non-small cell lung carcinoma]. (17327058)
2006
34
Time delay and its effect on survival in malaysian patients with non-small cell lung carcinoma. (22589589)
2006
35
Long-term outcome after resection of non-small cell lung carcinoma complicated by pneumoconiosis. (16998679)
2006
36
A case of recurrent non-small-cell lung carcinoma and paraneoplastic Cushing's syndrome. (16352372)
2006
37
Interleukin-8 in non-small cell lung carcinoma: relation with angiogenic pattern and p53 alterations. (16125276)
2005
38
Preclinical anti-tumor activity of XR5944 in combination with carboplatin or doxorubicin in non-small-cell lung carcinoma. (16162971)
2005
39
Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas. (16103075)
2005
40
The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. (12819188)
2003
41
Expression of vascular endothelial growth factor mRNA in non-small-cell lung carcinomas. (9888482)
1999
42
Expression of vascular endothelial growth factor (VEGF) and its two receptors (VEGF-R1-Flt1 and VEGF-R2-Flk1/KDR) in non-small cell lung carcinomas (NSCLCs): correlation with angiogenesis and survival. (10440746)
1999
43
Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma. (9850082)
1998
44
Prognostic value of basic fibroblast growth factor and its receptor (FGFR-1) in patients with non-small cell lung carcinomas. (9274456)
1997
45
Recurrence and death in non-small cell lung carcinomas: a prognostic model using pathological parameters, microvessel count, and gene protein products. (9816269)
1996
46
Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance. (8957065)
1996
47
Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma. (7606711)
1995
48
bcl-2 protein in non-small-cell lung carcinoma. (8264763)
1994
49
Overexpression of oncoproteins in non-small cell lung carcinomas of smokers. (8389672)
1993
50
Elevated expression of thymidylate synthase in doxorubicin resistant human non small cell lung carcinomas. (1338282)
1992

Variations for Non-Small Cell Lung Carcinoma

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Non-Small Cell Lung Carcinoma:

65
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Clinvar genetic disease variations for Non-Small Cell Lung Carcinoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> T (p.Gly12Cys)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
2PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
3PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
4BRAFNM_004333.4(BRAF): c.1799T> A (p.Val600Glu)single nucleotide variantPathogenicrs113488022GRCh37Chr 7, 140453136: 140453136
5BRAFNM_004333.4(BRAF): c.1789C> G (p.Leu597Val)single nucleotide variantPathogenicrs121913369GRCh37Chr 7, 140453146: 140453146
6FASLGNM_000639.1(FASLG): c.-844C=single nucleotide variantPathogenic, risk factorrs763110GRCh37Chr 1, 172627498: 172627498
7PPP2R1BNM_181699.2(PPP2R1B): c.269G> A (p.Gly90Asp)single nucleotide variantPathogenicrs1805076GRCh37Chr 11, 111635566: 111635566
8SLC22A18NM_183233.2(SLC22A18): c.698C> T (p.Ser233Phe)single nucleotide variantPathogenicrs121909071GRCh37Chr 11, 2939260: 2939260

Expression for genes affiliated with Non-Small Cell Lung Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Non-Small Cell Lung Carcinoma

Search GEO for disease gene expression data for Non-Small Cell Lung Carcinoma.

Pathways for genes affiliated with Non-Small Cell Lung Carcinoma

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Sources:
51PathCards, 61Thomson Reuters, 54QIAGEN, 56Reactome
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Pathways related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2EGFR, BRAF
2
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
10.0ARTN, EGFR, BRAF

Compounds for genes affiliated with Non-Small Cell Lung Carcinoma

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB
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Compounds related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1panitumumab46 52 1212.3EGFR, BRAF
2cetuximab46 52 1212.2EGFR, BRAF
3sodium iodide4610.2NKX2-1, BRAF
4regorafenib52 1211.1BRAF, EGFR
5iodide46 2510.9NKX2-1, BRAF

GO Terms for genes affiliated with Non-Small Cell Lung Carcinoma

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17Gene Ontology
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Biological processes related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex cell migrationGO:02179510.2EGFR, NKX2-1

Molecular functions related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase kinase kinase activityGO:00470910.2EGFR, BRAF

Products for genes affiliated with Non-Small Cell Lung Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Non-Small Cell Lung Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet