Non-small Cell Lung Carcinoma malady

Wikipedia: Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung...⁴⁴ more...

MalaCards: Non-small Cell Lung Carcinoma, also known as nonsmall cell lung cancer, is related to carcinoma and lung carcinoma. An important gene associated with Non-small Cell Lung Carcinoma is BRAF (v-raf murine sarcoma viral oncogene homolog B1), and among its related pathways are PTEN Pathway and Renal cell carcinoma. The drugs hydroxyurea and vinorelbine and the compounds glucose and atp have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and thyroid, and related mouse phenotypes are mortality/aging and growth/size.

OMIM: 211980

Aliases & Descriptions:

non-small cell lung carcinoma 6 8 nonsmall cell lung cancer 7 33 nsclc 6 32 non-small cell lung cancer (disorder) 6

carcinoma, non-small-cell lung 43 carcinoma non-small cell lung 32 carcinoma of lung 43

Diseases related to non-small cell lung carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 865)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	49.1	PIGR, RELA, KIT, VSNL1, SFTPA1, SFTPB
2	lung carcinoma	45.8	SFTPB, SFTPD, PCNA, RB1, NAPSA, BRAF
3	adenocarcinoma	34.6	PIGR, RELA, KIT, SFTPB, SFTPC, SFTPD
4	squamous cell carcinoma	34.2	RBP1, LGALS3, CD44, CDH1, MMP7, MKI67
5	small cell carcinoma	33.3	KIT, PCNA, RB1, VIM, VEGFA, RASSF1
6	mediastinitis	33.0	KIT, PCNA, VIM, VEGFC, MYC, MPO
7	pulmonary sclerosing hemangioma	32.2	SFTPA1, SFTPB, MYC, CHGA, MUC1, CDH1
8	xeroderma pigmentosum	32.0	PCNA, PARP1, BCL2, BAX, CDKN2A, MMP1
9	pituitary tumor	32.0	RB1, BMP2, PBX1, LGALS3, CHGA, CDKN1B
10	sclerosing hemangioma	31.9	SFTPA1, SFTPB, RB1, NAPSA, MYC, CHGA
11	small-cell cancer of lung	31.8	KIT, RB1, VHL, VEGFC, MYC, MYCL1
12	dna topoisomerase i	31.6	PARP1, JUN, CDKN2A, MKI67, FGF2, IL1B
13	lung giant cell carcinoma	31.2	PCNA, CDKN2A, CDH1, MMP2, IL8, KRT18
14	hemangioma	31.1	RELA, SFTPA1, SFTPB, RB1, VHL, VEGFA
15	bronchogenic carcinoma	30.9	CEACAM5, CDKN1A, CDKN2A, IL10, MDM2, ENO2
16	t-cell leukemia	30.1	RELA, MYC, RAF1, BIRC3, BIRC5, BCL2
17	retinoblastoma	29.9	KIT, PCNA, RB1, VIM, VHL, VEGFA
18	chronic obstructive pulmonary disease	29.8	SFTPB, SFTPD, PARP1, MPO, MMP1, MMP9
19	ovarian mucinous neoplasm	29.6	MUC16, LAMC2, MMP7, MMP9, TP53, WT1
20	neuroendocrine carcinoma	29.6	KIT, CHGA, MUC1, CEACAM5, CDH1, MMP7
21	merkel cell carcinoma	29.4	KIT, KDR, CHGA, MUC1, FHIT, ENO2
22	lung occult squamous cell carcinoma	29.1	PCNA, BRAF, CLDN7, BCL2, S100A2, S100A4
23	thyroiditis	29.0	RELA, KIT, SFTPA1, SFTPB, SFTPC, SFTPD
24	hypoxia	28.9	RELA, KIT, SFTPA1, SFTPB, SFTPC, PCNA
25	thyroid cancer	28.8	BRAF, LGALS3, S100A4, APC, TP63, TERT
26	glioblastoma	28.5	RB1, VHL, VEGFA, BIRC5, PARP1, KDR
27	ataxia	28.3	VSNL1, PCNA, VIM, MYC, RARA, BIRC2
28	leukemia	28.2	RELA, KIT, SFTPD, PCNA, RB1, RBP1
29	ataxia telangiectasia	28.1	PCNA, VIM, MYC, BIRC2, PARP1, BCL2
30	esophageal squamous cell carcinoma	28.1	RELA, KIT, PCNA, RB1, RBP1, VHL
31	esophagitis	27.8	RELA, KIT, SFTPD, PCNA, RB1, RBP1
32	malignant mesothelioma	27.7	KIT, SFTPB, PCNA, RB1, VIM, NAPSA
33	pulmonary disease	27.4	SFTPA1, SFTPB, SFTPC, SFTPD, PCNA, VEGFA
34	lung adenocarcinoma	26.7	SFTPB, SFTPC, SFTPD, RB1, NAPSA, BRAF
35	copd	26.4	RELA, SFTPB, SFTPD, VEGFA, BMP6, RARA
36	neuronitis	25.5	RELA, KIT, VSNL1, PCNA, RB1, VIM
37	lung cancer susceptibility	24.1	SFTPD, PCNA, VEGFA, MYC, MYCL1, RASSF1
38	non-hodgkin lymphoma	14.8	MYC, BIRC2, BIRC3, BIRC5, BCL2, BCL2L1
39	thyroid medullary carcinoma	14.7	BRAF, VEGFC, LGALS3, CKS1B, CHGA, CEACAM5
40	chronic lymphocytic leukemia	14.7	BIRC2, BIRC3, BIRC5, BCL2, BCL2L1, BAK1
41	lung benign neoplasm	14.6	SFTPB, SFTPC, SFTPD, RB1, BMP2, BMP4
42	urinary bladder cancer	14.6	RB1, RASSF1, BIRC5, KDR, CDKN1A, CDK2
43	papillary renal cell carcinoma	14.5	KIT, PCNA, VHL, VEGFA, VEGFC, RASSF1
44	ovarian cancer	14.5	RB1, CDKN1A, CDK2, CDKN2B, CDKN1B, CDKN2A
45	pancreatic endocrine tumors	14.5	VHL, VEGFC, RARB, BCL2, CHGA, CEACAM5
46	hodgkin's lymphoma	14.5	SERPINB9, BIRC2, BIRC3, BCL2, BCL2L1, XIAP
47	basal cell carcinoma	14.5	RARA, BCL2, LGALS3, BAK1, BAX, LAMC2
48	b-cell lymphomas	14.5	RB1, MYC, BIRC2, BIRC3, BIRC5, PARP1
49	alveolar rhabdomyosarcoma	14.5	RB1, VIM, XAGE1A, XAGE1B, XAGE1C, XAGE1D
50	large cell carcinoma	14.5	BCL2, CHGA, BAK1, BAX, ENO2, TP53

Clinical features from OMIM: 211980

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 docetaxel, hydroxyurea, irinotecan, irinotecan hydrochloride, topotecan, topotecan hydrochloride, vinorelbine, vinorelbine tartrate

MalaCards organs/tissues related to non-small cell lung carcinoma:

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MGI Mouse Phenotypes related to non-small cell lung carcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	11.7	RELA, SFTPB, SFTPC, SFTPD, RB1, SEMA5A
2	growth/size phenotype	MP:0005378	11.6	RELA, KIT, SFTPC, SFTPD, RB1, RBP1
3	hematopoietic system phenotype	MP:0005397	11.4	PIGR, KIT, PCNA, RBP1, SERPINB9, BRAF
4	embryogenesis phenotype	MP:0005380	11.3	KIT, VIM, BRAF, VHL, MYC, BMPR2
5	endocrine/exocrine gland phenotype	MP:0005379	11.3	CDKN2B, CDKN1B, CDC25B, ING2, FGFR1, APAF1
6	craniofacial phenotype	MP:0005382	11.1	KIT, BMP4, PBX1, PBX2, LAMB3, ITGB8
7	renal/urinary system phenotype	MP:0005367	11.1	KIT, BRAF, VHL, BMP4, RARA, RARB
8	respiratory system phenotype	MP:0005388	11.1	SFTPC, SFTPD, BMPR2, TP63, PLA2G4A, NOG
9	no phenotypic analysis	MP:0003012	10.9	SFTPC, PCNA, RB1, SEMA5A, VEGFA, MYC
10	immune system phenotype	MP:0005387	10.8	PIGR, KIT, RBP1, SERPINB9, VIM, BRAF
11	normal phenotype	MP:0002873	10.6	RELA, SEMA5A, BRAF, VHL, VEGFA, MYC
12	limbs/digits/tail phenotype	MP:0005371	10.4	RELA, KIT, RB1, VHL, VEGFA, BMP2
13	liver/biliary system phenotype	MP:0005370	10.3	KIT, RBP1, VHL, VEGFA, BMP4, PBX1
14	cellular phenotype	MP:0005384	10.3	RELA, KIT, PCNA, RB1, SERPINB9, VIM
15	behavior/neurological phenotype	MP:0005386	10.2	KIT, SFTPB, SFTPC, RB1, VIM, BRAF
16	pigmentation phenotype	MP:0001186	10.2	KIT, RB1, RBP1, BRAF, MYC, USF2
17	digestive/alimentary phenotype	MP:0005381	10.1	PIGR, KIT, RB1, BRAF, VHL, VEGFA
18	hearing/vestibular/ear phenotype	MP:0005377	10.0	KIT, RB1, RBP1, MYC, BMP2, BMP4
19	integument phenotype	MP:0010771	9.9	RELA, KIT, RB1, BRAF, VHL, MYC
20	other phenotype	MP:0005395	9.9	RARA, RARB, PBX1, KDR, LAMC2, CDKN2A
21	skeleton phenotype	MP:0005390	9.7	RELA, KIT, RB1, BRAF, VHL, VEGFA
22	nervous system phenotype	MP:0003631	9.6	RELA, KIT, RB1, RBP1, SEMA5A, BRAF
23	adipose tissue phenotype	MP:0005375	9.5	RB1, BRAF, MYC, BCL2, SAT1, CDKN1A
24	reproductive system phenotype	MP:0005389	9.4	PIGR, SFTPC, RBP1, VHL, VEGFA, BMP2
25	vision/eye phenotype	MP:0005391	8.8	RELA, KIT, SFTPC, RB1, RBP1, SEMA5A
26	homeostasis/metabolism phenotype	MP:0005376	8.2	PIGR, RELA, KIT, SFTPB, SFTPD, RB1
27	muscle phenotype	MP:0005369	8.1	RELA, KIT, RB1, VIM, BRAF, VHL
28	tumorigenesis	MP:0002006	7.9	KIT, SFTPC, RB1, BRAF, VHL, MYC
29	cardiovascular system phenotype	MP:0005385	7.2	RELA, KIT, SFTPC, RB1, SEMA5A, VIM

Articles related to non-small cell lung carcinoma:

(show top 50)    (show all 350)

id	Title	Authors	Year	Affiliating Genes
1	The prognostic value of RASSF1A promoter hypermethyla tion in non-small cell lung carcinoma: a systematic review and meta-analysis. (21156971)	Wang J.... Bi J.	2011	RASSF1
2	Increased VEGFR-2 gene copy is associated with chemor esistance and shorter survival in patients with non-small-cell lung carcinoma w ho receive adjuvant chemotherapy. (21724587)	Yang F.... Wistuba I.I.	2011	KDR
3	The expression of ADAM23 and its correlation with pro moter methylation in non-small-cell lung carcinoma. (21429053)	Hu C.... Zhou J.	2011	ADAM23
4	Aberrant promoter methylation of FBLN-3 gene and clin icopathological significance in non-small cell lung carcinoma. (19913326)	Wang R.... Chen L.B.	2010	EFEMP1
5	Pinpointing Pin1 in non-small cell lung carcinoma. (20023388)	Catanzaro J.... Zong W.X.	2010	NRP1
6	CD24, a novel cancer biomarker, predicting disease-fr ee survival of non-small cell lung carcinomas: a retrospective study of prognos tic factor analysis from the viewpoint of forthcoming (seventh) new TNM classif ication. (20354454)	Lee H.J.... Chung J.H.	2010	CD24
7	Porcupine expression is associated with the expressio n of S100P and other cancer-related molecules in non-small cell lung carcinoma. (20198348)	Bartling B.... Hofmann H.S.	2010	CTNNB1, JUN, S100P
8	Overexpression of hedgehog pathway molecules and FOXM 1 in non-small cell lung carcinomas. (19200615)	Gialmanidis I.P.... Papadaki H.	2009	GLI1, PTCH1, FOXM1
9	Review article: a reevaluation of the clinical significance of histological subtyping of non--small-cell lung carcinoma: diagnostic algorithms in the era of personalized treatments. (19443885)	Rossi G.... Papotti M.	2009	TP63, KRT7, NKX2-1
10	Synergistic effects of the purine analog sulfinosine and curcumin on the multidrug resistant human non-small cell lung carcinoma cel l line (NCI-H460/R). (18414057)	Andjelkovic T.... Ruzdijic S.	2008	ABCB1
11	EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. (18242762)	Shinmura K.... Sugimura H.	2008	TP53, KRAS, ALK
12	Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase. (18684922)	Coleman A.M.... Mitchell R.A.	2008	MIF, DDT
13	Erythropoietin receptor expression in non-small cell lung carcinoma: a question of antibody specificity. (17110616)	Brown W.M.... Lappin T.R.	2007	EPOR, HSPA1B
14	c-Met and HGF expression in non-small-cell lung carcinomas (17598453)	Korobko I.V.... Svwrdlov E.D.	2007	MET, HGF
15	S100A2-S100P expression profile and diagnosis of non-small cell lung carcinoma: impairment by advanced tumour stages and neoadjuvant chemotherapy. (17689067)	Bartling B.... Simm A.	2007	S100A4, S100A2
16	H-REV107-1 stimulates growth in non-small cell lung carcinomas via the activation of mitogenic signaling. (17003497)	Nazarenko I.... Sers C.	2006	PLA2G16
17	Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas. (16103075)	Shikada Y.... Sueishi K.	2005	VEGFA
18	Peroxisome proliferator-activated receptor-gamma ligands inhibit alpha5 integrin gene transcription in non-small cell lung carcinoma cells. (15677767)	Han S.... Roman J.	2005	EGF, PPARG, JUN
19	The functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma. (15930031)	Zhang J.... Kuang G.	2005	MMP7
20	No association between the C-1562T polymorphism in the promoter of matrix metalloproteinase-9 gene and non-small cell lung carcinoma. (15949868)	Wang Y.... Zhang J.	2005	MMP9
21	DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas. (14661059)	Yuan B.Z.... Reynolds S.H.	2004	DLC1
22	Expression and significance of telomerase reverse transcriptase and its regulators in non-small cell lung carcinoma (15025956)	Chen T.X.... Liu L.	2004	MYC, TP53, TERT
23	Absence of mutations in the VHL gene but frequent loss of heterozygosity at 3p25-26 in non-small cell lung carcinomas. (12609565)	Miyakis S.... Field J.K.	2003	VHL
24	Differential expression of inducible nitric oxide synthase and peroxisome proliferator-activated receptor gamma in non-small cell lung carcinoma. (12763220)	Lee T.W.... Yim A.P.	2003	PPARG, NOS2
25	Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line. (14499626)	Viktorsson K.... Shoshan M.C.	2003	MAPK8, BAX, BAK1
26	GST M1 and CYP1A1 gene polymorphism and daily fruit consumption in Turkish patients with non-small cell lung carcinomas. (14758730)	Ozturk O.... Gurses A.	2003	CYP1A1, GSTM1
27	Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells. (12243753)	Ekedahl J.... Zhivotovsky B.	2002	XIAP, BIRC2, BIRC3
28	Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells. (11948400)	Satoh T.... Mori M.	2002	PPARG, DDIT3
29	Prognostic factors and c-erbB-2 expression in non-small-cell lung carcinoma (c-erbB-2 in non-small cell lung carcinoma). (11847606)	Bakir K.... Elbeyli L.	2002	ERBB2
30	Significance and expression of vascular endothelial growth factor and E-cadherin in non-small cell lung Carcinomas. (12411157)	Mei T.... Ma Y.	2002	CDH1, VEGFA
31	Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas. (11986780)	Hirsch F.R.... Bunn P.A.	2002	ERBB2
32	Defective caspase-3 relocalization in non-small cell lung carcinoma. (11420700)	Joseph B.... Zhivotovsky B.	2001	CASP3, PARP1, CASP9
33	Bcl-2 expression as an apoptotic index in non small cell lung carcinomas. (11286130)	Kalogeraki A.... Delides G.S.	2001	BCL2
34	Expression of caspases-3, -6 and -8 and their relation to apoptosis in non-small cell lung carcinoma. (11410865)	TAPrmAonen-NAopAonkangas U.... PAoAokkAP P.	2001	CASP3, CASP8, CASP6
35	Relationship of the K-ras/c-mos expression patterns w ith angiogenesis in non-small cell lung carcinomas. (11778648)	Zacharatos P.... Gorgoulis V.G.	2001	VEGFA
36	Cell proliferation and apoptosis in stage III inoperable non-small cell lung carcinoma treated by radiotherapy. (10927139)	Langendijk H.... Wouters M.	2000	BCL2, TOP2A
37	Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma. (11156228)	Marrogi A.J.... Harris C.C.	2000	VEGFA, PTGS2, NOS2
38	Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein. (10413104)	Schnier J.B.... Senderowicz A.M.	1999	ALDH1A1
39	PD-ECGF, bFGF, and VEGF expression in non-small cell lung carcinomas and their association with lymph node metastasis. (10216471)	Volm M.... Mattern J.	1999	FGF2, VEGFA, TYMP
40	Serum anti-p53 autoantibodies in primary resected non-small-cell lung carcinoma. (9756419)	Iizasa T.... Ohwada H.	1998	TP53
41	Prognostic value of mutations and a germ line polymorphism of the p53 gene in non-small cell lung carcinoma: association with clinicopathological features. (9652798)	Tagawa M.... Kimura H.	1998	TP53
42	Mitomycin C, vinorelbine, carboplatin plus granulocyte-macrophage colony-stimulating factor for treatment of advanced non-small cell lung carcinoma. (9778620)	Hejna M.... Scheithauer W.	1998	CSF2
43	Angiogenesis correlates with vascular endothelial growth factor expression but not with Ki-ras oncogene activation in non-small cell lung carcinoma. (9815567)	Tsao M.S.... Viallet J.	1997	VEGFA
44	Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells. (9354460)	Sun S.Y.... Lotan R.	1997	RARS
45	Resistance to interleukin 6 in human non-small cell lung carcinoma cell lines: role of receptor components. (8809410)	Ganapathi M.K.... Kawamura K.	1996	IL6, IL6R
46	Heat shock (hsp70) and resistance proteins in non-small cell lung carcinomas. (7656230)	Volm M.... Stammler G.	1995	CAT, HSPA4
47	Surfactant protein gene expression in metastatic and micrometastatic pulmonary adenocarcinomas and other non-small cell lung carcinomas: detection by reverse transcriptase-polymerase chain reaction. (7671236)	Betz C.... MA1ller-Hermelink H.K.	1995	SFTPD, SFTPB, SFTPC
48	Identification of genes differentially expressed in normal lung and non-small cell lung carcinoma tissue. (7923146)	Schraml P.... Ludwig C.U.	1994	GLUL, ACTB
49	bcl-2 protein in non-small-cell lung carcinoma. (8264763)	Katz H.R.	1994	BCL2
50	Transient stabilization of p53 in non-small cell lung carcinoma cultures arrested for growth by retinoic acid. (8082749)	Maxwell S.A.... Mukhopadhyay T.	1994	TP53

Genes related to non-small cell lung carcinoma according to GeneCards:

(show top 50)    (show all 336)

id	Symbol	Description	Score	GeneCards Section Context
1	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.1	Summaries, Publications
2	LOC100506431	B2 RNA	11.0	Publications
3	CT45A2	cancer/testis antigen family 45, member A2	11.0	Orthologs
4	CT45A4	cancer/testis antigen family 45, member A4	11.0	Orthologs
5	MIR126	microRNA 126	11.0	Publications
6	TUSC1	tumor suppressor candidate 1	11.0	Expressions
7	SEPHS2	selenophosphate synthetase 2	11.0	Publications
8	DDT	D-dopachrome tautomerase	11.0	Publications
9	CTAG1A	cancer/testis antigen 1A	11.0	Publications
10	CT45A6	cancer/testis antigen family 45, member A6	11.0	Orthologs
11	CT45A1	cancer/testis antigen family 45, member A1	11.0	Orthologs
12	CT45A5	cancer/testis antigen family 45, member A5	11.0	Orthologs
13	CT45A3	cancer/testis antigen family 45, member A3	11.0	Orthologs
14	PORCN	porcupine homolog (Drosophila)	11.0	Publications
15	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	11.0	Publications
16	CHMP3	charged multivesicular body protein 3	11.0	Publications
17	S100P	S100 calcium binding protein P	11.0	Publications
18	TPBG	trophoblast glycoprotein	11.0	Publications
19	CTAG2	cancer/testis antigen 2	11.0	Expressions
20	HBXIP	hepatitis B virus x interacting protein	11.0	Publications
21	NAPSA	napsin A aspartic peptidase	11.0	Publications
22	XAGE1D	X antigen family, member 1D	11.0
23	PBX2	pre-B-cell leukemia homeobox 2	11.0	Publications
24	XAGE1C	X antigen family, member 1C	11.0
25	XAGE1B	X antigen family, member 1B	11.0
26	XAGE1A	X antigen family, member 1A	11.0
27	ING2	inhibitor of growth family, member 2	11.0	Publications
28	ADAM8	ADAM metallopeptidase domain 8	11.0	Publications
29	XAGE1E	X antigen family, member 1E	11.0
30	S100A2	S100 calcium binding protein A2	11.0	Publications
31	CLDN7	claudin 7	11.0	Publications
32	CKS1B	CDC28 protein kinase regulatory subunit 1B	11.0	Publications
33	MYCL1	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	11.0	Publications
34	NKX2-1	NK2 homeobox 1	11.0	Publications
35	CD24	CD24 molecule	11.0	Publications
36	DDX26B	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	11.0	Orthologs
37	SAGE1	sarcoma antigen 1	11.0	Orthologs
38	MAGEA4	melanoma antigen family A, 4	11.0	Publications
39	DUSP6	dual specificity phosphatase 6	11.0	Publications
40	CTAG1B	cancer/testis antigen 1B	11.0	Publications
41	MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2	11.0	Publications
42	NBPF3	neuroblastoma breakpoint family, member 3	11.0	Expressions
43	PIGR	polymeric immunoglobulin receptor	11.0	Publications
44	EPOR	erythropoietin receptor	11.0	Publications
45	DMTF1	cyclin D binding myb-like transcription factor 1	11.0	Expressions
46	PLA2G16	phospholipase A2, group XVI	11.0	Publications
47	RHOC	ras homolog family member C	11.0	Publications
48	EFS	embryonal Fyn-associated substrate	11.0	Publications
49	HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	11.0	Publications
50	SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	11.0	Publications

Pathways related to non-small cell lung carcinoma according to GeneDecks:

(show top 50)    (show all 287)

id	Pathway	Score	Top Affiliating Genes
1	PTEN Pathway36	11.2	KIT, SEMA5A, BRAF, VEGFC, BMP2, BMP4
2	Renal cell carcinoma20	11.2	VHL, RAF1, RAP1B, JUN, FIGF, MET
3	Melanoma20	11.1	RB1, BRAF, RAF1, CDKN1A, CDKN2A, CDH1
4	Tyrosine Kinases / Adaptors3	11.0	KIT, VEGFC, KDR, YES1, FLT1, FLT4
5	Paxillin Interactions36	11.0	KIT, SEMA5A, VEGFC, BMP2, BMP4, KDR
6	Pancreatic cancer20	11.0	RALBP1
7	Ras Pathway36	10.9	KIT, SEMA5A, BRAF, VEGFC, BMP2, BMP4
8	Development_HGF signaling pathway41	10.9	RAF1, SDC1, JUN, CDH1, FOS, MET
9	ILK Signaling36	10.9	KIT, SEMA5A, VIM, VEGFC, BMP2, BMP4
10	Focal adhesion20	10.8	BRAF, VEGFC, RAF1, RAP1B, BIRC2, BIRC3
11	CDC42 Pathway36	10.8	KIT, RAF1, PARD6A, KDR, JUN, CDH1
12	p53 Signaling36	10.7	BCL2, BAX, CDKN1A, FOS, MDM2, MAPK8
13	Transcription P53 signaling pathway10	10.7	RELA, VEGFA, CDK2, CDKN2A, MAPK8, MAPK9
14	Transcription_P53 signaling pathway41	10.6	RELA, RB1, VEGFA, KDR, BCL2, CDKN1A
15	ErbB2-ErbB3 Heterodimers36	10.6	RAF1, ERBB3, ERBB2, RPS6KB1, E2F1
16	ErbB signaling pathway20	10.6	BRAF, MYC, RAF1, JUN, CDKN1A, CDKN1B
17	Chronic myeloid leukemia20	10.5	RELA, RB1, BRAF, MYC, RAF1, BCL2L1
18	eIF2 Pathway36	10.4	KIT, SEMA5A, BRAF, VEGFC, BMP4, BMP6
19	Apoptosis and survival_FAS signaling cascades41	10.2	BIRC2, PARP1, BCL2, BAX, XIAP, CFLAR
20	Pancreatic Adenocarcinoma36	10.2	KIT, RB1, SEMA5A, BRAF, VEGFC, BMP2
21	Molecular Mechanisms of Cancer36	10.2	RB1, SEMA5A, VEGFC, MYC, BMP2, BMP4
22	Regulation of eIF4 and p70S6K36	10.2	VEGFC, BMP2, BMP4, BAX, ITGB8, FIGF
23	Prostate cancer20	10.2	RELA, RB1, BRAF, RAF1, BCL2, CDKN1A
24	Activation of PKA through GPCR36	10.1	KIT, SEMA5A, BRAF, VEGFC, BMP2, BMP4
25	Endometrial cancer20	10.1	BRAF, MYC, RAF1, CDH1, MLH1, APC
26	Activation of cAMP-Dependent PKA36	10.0	SEMA5A, VEGFC, BMP2, BMP4, RAF1, RAP1B
27	Small cell lung cancer20	10.0	RELA, RB1, MYC, RARB, BIRC2, BIRC3
28	PPAR Pathway36	10.0	KIT, SEMA5A, VEGFC, BMP2, BMP4, RAF1
29	Rac1 Pathway36	10.0	SEMA5A, BMP4, BMP6, RAF1, PARD6A, KDR
30	Epithelial Adherens Junctions36	10.0	SEMA5A, VEGFC, BMP2, BMP4, BMP6, RAP1B
31	Apoptosis and survival FAS signaling cascades10	9.9	BIRC2, PARP1, BCL2, BAX, XIAP, CFLAR
32	EGF Pathway36	9.9	BRAF, MYC, RAF1, MUC1, JUN, CDH1
33	IL-6 Pathway36	9.8	BRAF, BMP2, BMP4, BMP6, RAF1, BAX
34	Mitochondrial Apoptosis36	9.7	KIT, SEMA5A, VEGFC, BMP2, BMP4, BMP6
35	ERK5 Signaling36	9.7	KIT, SEMA5A, VEGFC, MYC, BMP2, BMP4
36	eNOS Signaling36	9.7	KIT, SEMA5A, BMP2, BMP6, FLT4, FIGF
37	Apoptosis20	9.6	RELA, BIRC2, BIRC3, BCL2, BCL2L1, BAX
38	Intracellular Calcium Signaling36	9.5	KIT, SEMA5A, VEGFC, BMP2, BMP4, BMP6
39	Nanog in Mammalian ESC Pluripotency36	9.3	KIT, SEMA5A, BRAF, VEGFC, BMP2, BMP4
40	Colorectal Cancer Metastasis36	9.1	BRAF, MYC, BIRC5, BCL2L1, BAX, MSH2
41	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	9.0	RELA, MYC, RAF1, BCL2, BAX, JUN
42	DHA Signaling36	9.0	KIT, SEMA5A, VEGFC, BMP2, BMP4, BMP6
43	ERK Signaling36	8.6	KIT, SEMA5A, BRAF, VEGFC, MYC, BMP2
44	MAPK Family Pathway36	8.6	SEMA5A, BRAF, VEGFC, BMP2, BMP4, BMP6
45	MIF Regulation of Innate Immune Cells36	8.2	BMP2, BMP4, BMP6, BCL2, BAX, JUN
46	p38 Signaling36	8.1	KIT, SEMA5A, VEGFC, BMP2, BMP4, BMP6
47	PAK Pathway36	8.1	KIT, SEMA5A, VEGFC, BMP2, BMP4, BMP6
48	Chagas disease (American trypanosomiasis)20	8.0	RELA, CFLAR, JUN, FOS, IRAK1, IL10
49	PEDF Induced Signaling36	7.9	RELA, BRAF, BMP2, BMP4, BMP6, RAF1
50	JAK-STAT Pathway36	7.8	KIT, SEMA5A, VEGFC, MYC, BMP2, BMP4

Compounds related to non-small cell lung carcinoma according to GeneDecks:

(show top 50)    (show all 472)

id	Compound	Score	Top Affiliating Genes
1	glucose32	12.4	KIT, BRAF, VHL, VEGFC, PARD6A, MUC16
2	atp32	11.7	KIT, SFTPB, RB1, SEPHS2, BRAF, VCP
3	proline32	11.7	VIM, VHL, LGALS3, MSH2, CDH1, MMP2
4	calcium32 9 18 9	14.6	PIGR, RELA, KIT, SFTPA1, SFTPB, SFTPC
5	p00332	11.3	KIT, RB1, RASSF1, CHGA, MVP, CEACAM5
6	glyceraldehyde 3-phosphate32	10.9	VEGFC, RARS, BIRC5, LGALS3, SAT1, CEACAM5
7	hoechst 3334232	10.8	SFTPB, PCNA, BIRC5, PARP1, BCL2, BAX
8	dmso32	10.8	VIM, BMP6, CHGA, MMP3, MMP7, F3
9	methionine32	10.6	KIT, SFTPC, VIM, RASSF1, CHGA, MTAP
10	cysteine32	10.6	SFTPB, SFTPC, SFTPD, PCNA, BMP4, RARA
11	manumycin32	10.6	RAF1, MAPK8, HRAS, SRC, EGF, EGFR
12	sorafenib32 9 9	12.6	KIT, BRAF, VHL, VEGFA, RAF1, BIRC3
13	leptomycin b32	10.4	BIRC5, LGALS3, CDKN1A, CDKN1B, CDC25B, CDH1
14	dihydrotestosterone32 9 18 9	13.4	VIM, BMP2, BMP6, CDK2, FGF2, FAS
15	roscovitine32	10.4	PCNA, VIM, BIRC5, PARP1, BCL2L1, XIAP
16	phosphotyrosine32	10.4	KIT, RAF1, KDR, YES1, CDK2, CDKN3
17	nocodazole32 42 9 9	13.3	PIGR, VIM, RAF1, BIRC5, CDKN1A, CDKN3
18	retinoid32	10.3	SFTPB, RBP1, VIM, MYC, BMP2, BMP4
19	progestin32	10.3	VIM, VEGFA, KDR, CDH1, CCND1, ESR2
20	paraffin32	10.2	RELA, KIT, SFTPB, PCNA, RB1, RBP1
21	nitric oxide32 9 18 9	13.2	KIT, SFTPB, SFTPD, RB1, VHL, VEGFC
22	sulindac sulfide32	10.1	PCNA, BMP6, BCL2, BCL2L1, BAX, JUN
23	adp32 18	11.1	KIT, BRAF, VCP, BMPR2, RAF1, RAP1B
24	pd 16931632	10.0	VEGFA, BMP4, PARP1, BCL2, MAPK8, MAPK1
25	adpribose32	10.0	PCNA, RB1, BIRC5, PARP1, BCL2, BCL2L1
26	betacarotene32	9.9	PCNA, RB1, RBP1, RARA, RARS, RARB
27	3,3-diindolylmethane32	9.9	VEGFA, BIRC5, PARP1, BAX, CFLAR, CDKN1A
28	phorbol32	9.9	MYC, RAF1, CHGA, JUN, CDKN1A, CDK2
29	calcitriol32 42 9 18 9	13.9	RB1, MYC, BMP2, BMP6, RARA, RARS
30	silymarin32	9.9	PCNA, VEGFA, BMP6, BIRC5, PARP1, JUN
31	dfmo32	9.9	MYC, BIRC3, SAT1, CDKN1A, CDK2, CDH1
32	okadaic acid32 42	10.8	RELA, RB1, VIM, MYC, BMP6, RAF1
33	trastuzumab32 34 9 9	12.8	KIT, VEGFC, RAF1, BIRC5, KDR, MUC1
34	n-(4-hydroxyphenyl)retinamide32	9.8	RB1, RBP1, VIM, MYC, BMP6, RARA
35	4-hydroxytamoxifen32	9.8	SERPINB9, MYC, PARP1, JUN, FASLG, MAPK1
36	doxycycline32 9 9	11.7	SFTPB, SFTPC, CDK2, CDKN2B, CDKN2A, MMP1
37	aspartate32	9.5	PCNA, VIM, BRAF, BMP6, RARA, RAF1
38	tetracycline32 9 9	11.5	SFTPC, RB1, BMP2, SAT1, CDK2, CDKN2A
39	parthenolide32	9.0	BIRC3, BCL2L1, MMP9, IL6, IL8, FASLG
40	arsenite32 18	10.0	PCNA, VEGFA, MYC, RARA, BIRC2, BIRC5
41	prostacyclin32	9.0	VEGFA, BMP6, KDR, FLT1, FGF2, IL10
42	arachidonic acid32 9 18 9	11.9	VIM, BCL2L1, CDH1, FOS, MIF, GRP
43	tamoxifen32 34 9 9	11.8	PCNA, SERPINB9, VIM, VEGFA, MYC, BMP6
44	imatinib32 34 9 9	11.7	KIT, BRAF, VEGFA, MYC, BMP6, RARA
45	4-hydroxynonenal32 18	9.7	MYC, RALBP1, PARP1, BAX, MPO, JUN
46	thalidomide32 42 9 9	11.0	VEGFA, BIRC2, BIRC3, BIRC5, KDR, BCL2L1
47	thymidine32 18	9.0	KIT, SFTPB, SFTPD, PCNA, RB1, VEGFC
48	15-deoxy-delta-12,14-prostaglandin j232	7.8	VEGFA, MYC, BMP6, BIRC2, BIRC5, BCL2L1
49	hydrocortisone32 9 9	9.2	VIM, BMP6, PBX1, KDR, MUC1, MMP1
50	curcumin32	7.0	VEGFA, MYC, RAF1, BIRC2, BIRC3, BIRC5

Cellular components related to non-small cell lung carcinoma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	11.4	PLAUR, SSTR2, DDR2, DDR1, PTPRA, TEK
2	cytoplasm	GO:005737	11.2	AIF1, SSTR2, CTAG1A, CTNNB1, PPIG, NR1H2
3	nucleoplasm	GO:005654	10.6	RELA, PCNA, RB1, VHL, MYC, RARA
4	nucleus	GO:005634	10.6	CCND1, TP53, TP63, TP73, PTEN, PTGS2
5	perinuclear region of cytoplasm	GO:048471	10.3	KRT18, RPS6KB1, NOS2, NOS1, PLA2G16, EGFR
6	caveola	GO:005901	9.9	SLC2A1, TGFBR2, SRC, DLC1, PTGS2, PTCH1
7	cytosol	GO:005829	9.8	NQO1, TYMP, TYMS, TK1, STAT3, STAT5B
8	cell surface	GO:009986	9.8	PLAU, PLAUR, RPS6KB1, ABCB1, TIMP2, TGFA
9	extracellular region	GO:005576	9.1	PIGR, SFTPA1, SFTPD, VEGFA, VEGFC, BMP2
10	plasma membrane	GO:005886	9.1	NFE2L2, RHOA, RHOC, RHOD, KRAS, EDNRB
11	extracellular space	GO:005615	8.4	SST, EPO, HGF, PLAU, NOG, EDN1

Biological processes related to non-small cell lung carcinoma according to GeneDecks:

(show top 50)    (show all 79)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:043154	11.2	SERPINB9, VEGFA, RAF1, BIRC5, XIAP, CD27
2	cell proliferation	GO:008283	11.1	PCNA, RAF1, RAP1B, BCL2L1, CKS1B, BAK1
3	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	11.0	KIT, KDR, FLT1, FGFR1, ANGPT1, F2R
4	response to organic cyclic compound	GO:014070	10.9	BMP4, BAK1, MSH2, JUN, CDKN1A, MET
5	activation of MAPKK activity	GO:000186	10.8	BMP4, RAF1, F2R, CRK
6	positive regulation of endothelial cell migration	GO:010595	10.8	VEGFA, BMP4, BMPR2, KDR, FLT4, ANGPT1
7	peptidyl-tyrosine phosphorylation	GO:018108	10.8	KIT, KDR, FLT1, FLT4, FGFR1, TEK
8	induction of apoptosis by intracellular signals	GO:008629	10.7	MYC, BCL2, BCL2L1, BAK1, BAX, XIAP
9	angiogenesis	GO:001525	10.7	VEGFA, VEGFC, KDR, SAT1, CEACAM1, JUN
10	positive regulation of endothelial cell proliferation	GO:001938	10.7	VEGFA, BMP2, BMP4, BMP6, BMPR2, KDR
11	negative regulation of neuron apoptotic process	GO:043524	10.7	BRAF, BCL2, BCL2L1, BAX, MSH2, JUN
12	Ras protein signal transduction	GO:007265	10.6	RB1, RAF1, RASSF1, CDKN1A, CDK2, CDKN2A
13	positive regulation of gene expression	GO:010628	10.6	KIT, BRAF, VEGFA, BMP2, CD44, MET
14	release of cytochrome c from mitochondria	GO:001836	10.5	MYC, BCL2, BCL2L1, BAK1, BAX, JUN
15	positive regulation of neuron apoptotic process	GO:043525	10.5	BAX, JUN, FASLG, CASP3, CASP6, CASP9
16	activation of pro-apoptotic gene products	GO:008633	10.5	MYC, BCL2, BAK1, BAX, GZMB, FASLG
17	negative regulation of transcription from RNA polymerase II promoter	GO:000122	10.4	VHL, MYC, BMP2, BMP4, RARB, PARP1
18	response to mechanical stimulus	GO:009612	10.3	BMP2, BMP4, JUN, MMP9, ANGPT2, F3
19	heart development	GO:007507	10.3	PCNA, BMP2, RAF1, CASP3, CASP8, ERBB3
20	positive regulation of cell migration	GO:030335	10.2	VEGFA, BMP2, KDR, FLT1, APC, F3
21	cell cycle arrest	GO:007050	10.2	RB1, MYC, RASSF1, MSH2, CDKN1A, CDKN2B
22	response to lipopolysaccharide	GO:032496	10.2	SFTPB, SFTPC, JUN, MMP9, IRAK1, IL1A
23	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.1	BRAF, BMP2, BMP4, KDR, CD44, FLT4
24	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.1	VCP, MYC, BAX, CDKN1B, CDKN2A, APAF1
25	positive regulation of angiogenesis	GO:045766	10.1	VEGFA, KDR, MMP9, FLT1, FGF2, IL1A
26	positive regulation of peptidyl-serine phosphorylation	GO:033138	10.0	BRAF, VEGFA, RAF1, BCL2, CD44, MIF
27	negative regulation of apoptotic process	GO:043066	10.0	RELA, BRAF, VEGFA, MYC, BMP4, RAF1
28	positive regulation of smooth muscle cell proliferation	GO:048661	10.0	BMP4, JUN, FLT1, IL6, IL6R, AIF1
29	epidermal growth factor receptor signaling pathway	GO:007173	9.9	RAF1, CDKN1B, MDM2, MAPK1, CASP9, HRAS
30	positive regulation of epithelial cell proliferation	GO:050679	9.9	VEGFC, MYC, BMP4, BMP6, HRAS, ERBB2
31	positive regulation of apoptotic process	GO:043065	9.7	BMP2, BMP4, RARB, BAK1, BAX, MMP9
32	positive regulation of protein phosphorylation	GO:001934	9.7	VEGFA, BMP2, BMP4, FLT4, IL1B, ENG
33	apoptotic process	GO:006915	9.7	VIM, RAF1, BIRC2, BIRC3, BIRC5, BCL2
34	induction of apoptosis	GO:006917	9.7	BAX, CD27, CDKN1B, CDKN2A, FASLG, FAS
35	response to drug	GO:042493	9.6	VEGFC, MYC, BCL2, MVP, BAK1, MSH2
36	response to estradiol stimulus	GO:032355	9.6	BMP4, RARA, MMP9, IL1B, ENO2, F3
37	positive regulation of MAP kinase activity	GO:043406	9.6	VEGFA, CD24, FLT1, FGFR1, ERBB2, TNF
38	response to hypoxia	GO:001666	9.5	SFTPB, VEGFA, BMP2, RAF1, USF1, BCL2
39	positive regulation of cell proliferation	GO:008284	9.4	KIT, VEGFA, VEGFC, MYC, RARA, BIRC5
40	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.4	RELA, RB1, VEGFA, MYC, BMP2, BMP4
41	blood coagulation	GO:007596	9.4	VEGFA, VEGFC, RAF1, RAP1B, YES1, CDK2
42	platelet activation	GO:030168	9.3	VEGFA, VEGFC, RAF1, RAP1B, FIGF, IL6
43	anti-apoptosis	GO:006916	9.3	RELA, SERPINB9, BRAF, VHL, BIRC2, BIRC3
44	positive regulation of cell division	GO:051781	9.3	VEGFA, VEGFC, FIGF, FGF2, IL1A, IL1B
45	aging	GO:007568	9.1	BAK1, JUN, IL1B, FAS, F3, DDIT3
46	response to glucocorticoid stimulus	GO:051384	9.0	SFTPB, SFTPC, IL10, IL1B, IL6, FAS
47	signal transduction	GO:007165	8.8	KIT, VEGFC, RARA, RARB, RAF1, RALBP1
48	negative regulation of cell proliferation	GO:008285	8.6	VHL, BMP2, BMP4, RARB, RAF1, BAK1
49	positive regulation of transcription, DNA-dependent	GO:045893	8.2	RELA, RB1, VHL, MYC, BMP2, BMP4
50	inflammatory response	GO:006954	8.0	RELA, KIT, BMP2, BMP6, FOS, MIF

Molecular functions related to non-small cell lung carcinoma according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:042803	11.0	NOS2, NOG, SMAD4, PTGS2, TERT, ERBB3
2	ATP binding	GO:005524	10.9	DDR1, DDR2, SRC, RPS6KB1, EGFR, TEK
3	chemoattractant activity	GO:042056	10.8	FGF2, FIGF, MIF, BMP4, VEGFC, VEGFA
4	transmembrane receptor protein tyrosine kinase activity	GO:004714	10.7	TEK, DDR1, DDR2, EGFR, TIE1, ERBB2
5	protein binding	GO:005515	10.7	ADAM23, EFEMP1, RIPK1, NEDD4, NKX2-1, NME1
6	identical protein binding	GO:042802	10.6	S100A4, BAX, BAK1, BCL2L1, BCL2, CLDN7
7	sequence-specific DNA binding	GO:043565	10.4	HIF1A, WT1, NFE2L2, SMAD4, SNAI1, AHR
8	protein heterodimerization activity	GO:046982	10.4	HGF, NPM1, TGFB2, TGFB1, TOP2A, TWIST1
9	transcription factor binding	GO:008134	10.3	HMGB1, TP53, TP73, DDIT3, CTNNB1, HIF1A
10	protein kinase binding	GO:019901	10.1	CCND1, HSPB1, TP53, TP73, PTEN, ACTB
11	enzyme binding	GO:019899	9.7	CSF3, MSH2, YES1, BIRC5, USF1, RARA
12	transcription regulatory region DNA binding	GO:044212	9.7	PPARG, SMAD4, WT1, HIF1A, AHR, TFAP2A
13	growth factor activity	GO:008083	8.7	TYMP, TGFA, TGFB1, TGFB2, TFF1, CSF2
14	cytokine activity	GO:005125	8.1	FASLG, HMGB1, TNF, TNFSF10, EDN1, TGFB2