NSCLC
MCID: NNS005
MIFTS: 43

Non-Small Cell Lung Carcinoma (NSCLC) malady

Summaries for Non-Small Cell Lung Carcinoma

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung... more...

MalaCards: Non-Small Cell Lung Carcinoma, also known as nonsmall cell lung cancer, is related to adenocarcinoma and thyroid cancer. An important gene associated with Non-Small Cell Lung Carcinoma is EGFR (epidermal growth factor receptor). The drugs hydroxyurea and vinorelbine and the compounds sodium iodide and panitumumab have been mentioned in the context of this disorder.

Description from OMIM:47 211980

Aliases & Classifications for Non-Small Cell Lung Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 9diseasecard, 22GTR, 47OMIM, 35MeSH, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

non-small cell lung carcinoma 8 10 61
nonsmall cell lung cancer 9 22 47
nsclc 8 45
carcinoma non-small cell lung 45
non-small cell lung cancer 8


External Ids:

Disease Ontology8 DOID:3908
MeSH35 D002289
SNOMED-CT57 254637007
NCIt40 C2926

Related Diseases for Non-Small Cell Lung Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Non-Small Cell Lung Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.9BRAF, CTAG1B, EGFR, MAGEA4, XAGE1D, NKX2-1
2thyroid cancer29.9BRAF, NKX2-1
3small cell carcinoma11.7
4lung cancer, somatic10.9
5thoracic cancer10.8
6colorectal cancer10.8
7squamous cell carcinoma10.7
8idiopathic pulmonary fibrosis10.7
9radiation induced cancer10.7
10bone marrow cancer10.7
11colon cancer, advanced10.6
12adrenal carcinoma10.6
13germ cell cancer10.6
14bone carcinoma10.6
15nonsmall cell lung cancer, somatic10.6
16thrombocytosis10.5
17spontaneous pneumothorax10.5
18cardia cancer10.5
19toxic epidermal necrolysis10.5
20lung cancer, egfr-related10.5
21neuroendocrine carcinoma10.5
22lung superior sulcus carcinoma10.5
23gastric small cell carcinoma10.5
24lung occult small cell carcinoma10.5
25large cell carcinoma10.5
26nonsmall cell lung cancer, response to tyrosine kinase inhibitor in10.4
27spinal cancer10.4
28wilms tumor10.4
29mutagen sensitivity10.4
30non-small cell lung cancer, childhood10.4
31thromboembolism10.4
32cancer progression/metastasis10.4
33venous thromboembolism10.4
34leukopenia10.4
35parathyroid carcinoma10.4
36lung carcinoma in situ10.4
37colon small cell carcinoma10.4
38lung lymphoma10.4
39bronchogenic carcinoma10.4
40t-cell leukemia10.4
41anaplastic small cell lymphoma10.4
42hypoxia10.4
43pulmonary disease, chronic obstructive10.4
44somatostatin analog10.4
45pharyngitis10.3
46xeroderma pigmentosum, group b10.3
47lung cancer susceptibility 510.3
48paronychia10.2
49acute interstitial pneumonia10.2
50myelitis10.2

Graphical network of the top 20 diseases related to Non-Small Cell Lung Carcinoma:



Diseases related to non-small cell lung carcinoma

Clinical Features for Non-Small Cell Lung Carcinoma

Sources:
47OMIM
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Clinical features from OMIM:

211980

Drugs & Therapeutics for Non-Small Cell Lung Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Non-Small Cell Lung Carcinoma

Drug clinical trials:

Search ClinicalTrials for Non-Small Cell Lung Carcinoma

Search NIH Clinical Center for Non-Small Cell Lung Carcinoma

Search CenterWatch for Non-Small Cell Lung Carcinoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Non-Small Cell Lung Carcinoma

Sources:
22GTR
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Genetic tests related to Non-Small Cell Lung Carcinoma:

id Genetic test Affiliating Genes
1 Non-small Cell Lung Cancer22

Anatomical Context for Non-Small Cell Lung Carcinoma

Animal Models for Non-Small Cell Lung Carcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Non-Small Cell Lung Carcinoma

Sources:
51PubMed
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Articles related to Non-Small Cell Lung Carcinoma:

idTitleAuthorsYear
1
Circadian variability of pharmacokinetics of cisplatin in patients with non-small-cell lung carcinoma: analysis with the NONMEM program. (24061864)
2013
2
Evaluation of treatment response after nonoperative therapy for early-stage non-small cell lung carcinoma. (21263266)
2011
3
A review of noninvasive staging of the mediastinum for non-small cell lung carcinoma. (21986265)
2011
4
Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women. (20802022)
2010
5
Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma. (19273703)
2009
6
Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells. (17638906)
2007
7
Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line. (13679859)
2003
8
Comparison of DNA topoisomerase II alpha expression in small cell and nonsmall cell carcinoma of the lung. In search of a mechanism of chemotherapeutic response. (8756364)
1996
9
Nonconstitutive expression of the gastrin-releasing peptide autocrine growth system in human small cell lung carcinoma NCI-H345 cells. (8732666)
1996

Genetic Variations for Non-Small Cell Lung Carcinoma

Expression for genes affiliated with Non-Small Cell Lung Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Non-Small Cell Lung Carcinoma

Search GEO for disease gene expression data for Non-Small Cell Lung Carcinoma.

Pathways for genes affiliated with Non-Small Cell Lung Carcinoma

Compounds for genes affiliated with Non-Small Cell Lung Carcinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sodium iodide4510.7NKX2-1, BRAF
2panitumumab45 50 1112.4EGFR, BRAF

GO Terms for genes affiliated with Non-Small Cell Lung Carcinoma

Sources:
16Gene Ontology
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Biological processes related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex cell migrationGO:02179510.7NKX2-1, EGFR

Products for genes affiliated with Non-Small Cell Lung Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Non-Small Cell Lung Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet