NSCLC
MCID: NNS005
MIFTS: 58

Non-Small Cell Lung Carcinoma (NSCLC) malady

Respiratory diseases, Cancer diseases categories

Summaries for Non-Small Cell Lung Carcinoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung... more...

MalaCards: Non-Small Cell Lung Carcinoma, also known as nonsmall cell lung cancer, is related to colorectal cancer and lung adenocarcinoma. An important gene associated with Non-Small Cell Lung Carcinoma is EGFR (epidermal growth factor receptor), and among its related pathways are Development HGF signaling pathway and G-Beta Gamma Signaling. The drugs hydroxyurea and vinorelbine and the compounds panitumumab and cetuximab have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and lymph node, and related mouse phenotype pigmentation.

Description from OMIM:46 211980

Aliases & Classifications for Non-Small Cell Lung Carcinoma

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 9diseasecard, 22GTR, 46OMIM, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

non-small cell lung carcinoma 8 10 60
nonsmall cell lung cancer 9 22 46
nsclc 8 44
carcinoma non-small cell lung 44
non-small cell lung cancer 8


External Ids:

Disease Ontology8 DOID:3908
MeSH34 D002289
SNOMED-CT56 254637007
NCIt39 C2926

Related Diseases for Non-Small Cell Lung Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Non-Small Cell Lung Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer31.1BRAF, EGFR
2lung adenocarcinoma30.8EGFR, BRAF
3ovarian cancer30.5BRAF, EGFR
4colon cancer30.3EGFR, BRAF
5small cell carcinoma11.7
6lung small cell carcinoma11.7
7lung cancer10.9
8thoracic cancer10.8
9esophageal cancer10.8
10lung squamous cell carcinoma10.7
11squamous cell carcinoma10.7
12mediastinitis10.7
13pulmonary fibrosis10.7
14idiopathic pulmonary fibrosis10.6
15lung carcinoma in situ10.6
16in situ carcinoma10.6
17retinoblastoma10.6
18bone carcinoma10.6
19adrenal carcinoma10.6
20adenocarcinoma10.6
21thrombocytosis10.5
22melanoma10.5
23pancreatic cancer10.5
24pancreatitis10.5
25pneumothorax10.5
26nonsmall cell lung cancer, somatic10.5
27neuroendocrine carcinoma10.5
28lung superior sulcus carcinoma10.5
29gastric small cell carcinoma10.5
30lung occult small cell carcinoma10.5
31leukemia10.5
32transitional cell carcinoma10.5
33neuroblastoma10.5
34nonsmall cell lung cancer, response to tyrosine kinase inhibitor in10.4
35parathyroid carcinoma10.4
36lung lymphoma10.4
37large cell carcinoma10.4
38encephalitis10.4
39esophagitis10.4
40lung large cell carcinoma10.4
41obstructive lung disease10.4
42thyroiditis10.4
43central nervous system cancer10.4
44conjunctivitis10.4
45nervous system cancer10.4
46pericardial effusion10.4
47prostate cancer10.4
48small intestine cancer10.4
49spinal cancer10.4
50non-small cell lung cancer, childhood10.4

Graphical network of the top 20 diseases related to Non-Small Cell Lung Carcinoma:



Diseases related to non-small cell lung carcinoma

Clinical Features for Non-Small Cell Lung Carcinoma

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Sources:
46OMIM
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Clinical features from OMIM:

211980

Drugs & Therapeutics for Non-Small Cell Lung Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Non-Small Cell Lung Carcinoma

Drug clinical trials:

Search ClinicalTrials for Non-Small Cell Lung Carcinoma

Search NIH Clinical Center for Non-Small Cell Lung Carcinoma

Search CenterWatch for Non-Small Cell Lung Carcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Non-Small Cell Lung Carcinoma

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22GTR
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Genetic tests related to Non-Small Cell Lung Carcinoma:

id Genetic test Affiliating Genes
1 Non-Small Cell Lung Cancer22

Anatomical Context for Non-Small Cell Lung Carcinoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Non-Small Cell Lung Carcinoma:

32
Lung, Endothelial, Lymph node, Brain, Testes, Bone, T cells, Testis, Thyroid, Breast, Prostate, Bronchial epithelium, Kidney, B cells, Liver, Pituitary, Bone marrow

Animal Models for Non-Small Cell Lung Carcinoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Non-Small Cell Lung Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.1EGFR, BRAF

Publications for Non-Small Cell Lung Carcinoma

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Sources:
50PubMed
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Articles related to Non-Small Cell Lung Carcinoma:

(show top 50)    (show all 829)
idTitleAuthorsYear
1
Identification of a Subset of Human Non-Small Cell Lung Cancer Patients with High PI3KI^ and Low PTEN Expression, More Prevalent in Squamous Cell Carcinoma. (24284056)
2014
2
ROS1 receptor tyrosine kinase, a druggable target, is frequently overexpressed in non-small cell lung carcinomas via genetic and epigenetic mechanisms. (22915320)
2013
3
Performance of integrated positron emission tomography/computed tomography for mediastinal nodal staging in non-small cell lung carcinoma. (23566971)
2013
4
Quantitative chemical proteomics profiling differentiates erlotinib from gefitinib in EGFR wild-type non-small cell lung carcinoma cell lines. (23371860)
2013
5
Radiotherapy for stage III non-small-cell lung carcinoma in the elderly (age a8Y 70 years). (23891240)
2013
6
Minnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivo. (24143232)
2013
7
Strengthening context-dependent anticancer effects on non-small cell lung carcinoma by inhibition of both MET and EGFR. (23720767)
2013
8
Inhibition of Ephrin B3-mediated survival signaling contributes to increased cell death response of non-small cell lung carcinoma cells after combined treatment with ionizing radiation and PKC 412. (23303128)
2013
9
Negative regulation of AMP-activated protein kinase (AMPK) activity by macrophage migration inhibitory factor (MIF) family members in non-small cell lung carcinomas. (22988252)
2012
10
Coalterations of p53 and PTEN tumor suppressor genes in non-small cell lung carcinoma patients. (21146147)
2011
11
Toxicity of hypofractionated accelerated radiotherapy concurrent with chemotherapy for non-small cell carcinoma of the lung. (21676603)
2011
12
Computed tomography appearances of local recurrence after stereotactic body radiation therapy for stage I non-small-cell lung carcinoma. (20512542)
2010
13
Expression of alpha-tubulin and MDR1 and their correlation with the biological features of non-small cell lung carcinoma]. (20510079)
2010
14
Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas. (20889565)
2010
15
Discoidin domain receptor 1 is associated with poor prognosis of non-small cell lung carcinomas. (20596615)
2010
16
Sequential treatment of superior vena cava syndrome caused by of non-small cell carcinoma lung cancer (NSCLC) with vascular stenting and iodine-125 implantation. (19645521)
2009
17
Defining genomic alteration boundaries for a combined small cell and non-small cell lung carcinoma. (19179901)
2009
18
Co-overexpression of Met and hepatocyte growth factor promotes systemic metastasis in NCI-H460 non-small cell lung carcinoma cells. (20019837)
2009
19
Phase II study of oral vinorelbine in combination with carboplatin followed by consolidation therapy with oral vinorelbine as single-agent in unresectable localized or metastatic non-small cell lung carcinoma. (19095327)
2009
20
Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas. (19200615)
2009
21
Cranial prophylactic irradiation in locally advanced non-small cell lung carcinoma: current status and future perspectives. (19218826)
2009
22
Rescue of major histocompatibility-DR surface expression in retinoblastoma-defective, non-small cell lung carcinoma cells by the MS-275 histone deacetylase inhibitor. (19252299)
2009
23
MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. (18602365)
2008
24
A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. (18316555)
2008
25
Expression of glucose transporter in non-small cell lung carcinoma and its clinical significance]. (18422279)
2008
26
Prognostic factors in resected T3 non-small cell lung carcinoma: perineural invasion as a new prognostic factor. (18278684)
2008
27
Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma. (17453000)
2007
28
Palmar fasciitis and polyarthritis syndrome associated with non-small-cell lung carcinoma. (17310269)
2007
29
Impaired downregulation following erythropoietin receptor activation in non-small cell lung carcinoma. (17038666)
2007
30
Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins. (18038880)
2007
31
H-REV107-1 stimulates growth in non-small cell lung carcinomas via the activation of mitogenic signaling. (17003497)
2006
32
Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-small-cell lung carcinoma. (16959370)
2006
33
Paraneoplastic optic neuropathy in a patient with a non-small cell lung carcinoma: a case report. (15945016)
2005
34
Phase II study of a fixed dose-rate infusion of gemcitabine associated with docetaxel in advanced non-small-cell lung carcinoma. (15322824)
2005
35
DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas. (14661059)
2004
36
Multivariate analysis of factors predictive of brain metastases in localised non-small cell lung carcinoma. (15301872)
2004
37
Endobronchial brachytherapy and optimization of local disease control in medically inoperable non-small cell lung carcinoma: a matched-pair analysis. (15607149)
2004
38
Role of metallothionein expression in non-small cell lung carcinomas. (15638370)
2004
39
High expression of nitric oxide synthases is a favorable prognostic sign in non-small cell lung carcinoma. (14678024)
2003
40
Expression of heat shock proteins HSP70 and HSP27 in primary non-small cell lung carcinomas. An immunohistochemical study. (11396134)
2001
41
The angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomas. (10880843)
2000
42
Expression and clinical significance of p53 protein and p21(WAF1) in non-small-cell lung carcinoma]. (11866928)
2000
43
Quantitation by competitive PCR assay of vascular endothelial growth factor in non-small cell lung carcinomas. (9863024)
1999
44
Paracrine effects of hepatocyte growth factor/scatter factor on non-small-cell lung carcinoma cell lines. (9649128)
1998
45
p27KIP1 in human lung cancers: differential changes in small cell and non-small cell carcinomas. (9500468)
1998
46
Prognostic value of mutations and a germ line polymorphism of the p53 gene in non-small cell lung carcinoma: association with clinicopathological features. (9652798)
1998
47
Interrelationships between microvessel density, expression of VEGF and resistance to doxorubicin of non-small lung cell carcinoma. (8615611)
1996
48
bcl-2 protein in non-small-cell lung carcinoma. (8264763)
1994
49
Identification of genes differentially expressed in normal lung and non-small cell lung carcinoma tissue. (7923146)
1994
50
CD10/NEP in non-small cell lung carcinomas. Relationship to cellular proliferation. (7962523)
1994

Genetic Variations for Non-Small Cell Lung Carcinoma

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Non-Small Cell Lung Carcinoma:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Expression for genes affiliated with Non-Small Cell Lung Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Non-Small Cell Lung Carcinoma

Search GEO for disease gene expression data for Non-Small Cell Lung Carcinoma.

Pathways for genes affiliated with Non-Small Cell Lung Carcinoma

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Sources:
12EMD Millipore, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 59Tocris Bioscience, 49PharmGKB
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Pathways related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1EGFR, BRAF
2
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9.1EGFR, BRAF
3
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9.1EGFR, BRAF
49.1BRAF, EGFR
5
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9.1EGFR, BRAF
6
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9.1EGFR, BRAF
7
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9.1BRAF, EGFR
8
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9.1EGFR, BRAF
9
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9.1EGFR, BRAF
10
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9.1EGFR, BRAF
119.1EGFR, BRAF
12
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9.1BRAF, EGFR
13
Translation Insulin regulation of translation
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9.1EGFR, BRAF
14
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9.1EGFR, BRAF
15
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9.1EGFR, BRAF
16
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9.1BRAF, EGFR
179.1EGFR, BRAF
18
Hide members
9.1EGFR, BRAF
199.1EGFR, BRAF
20
Hide members
9.1BRAF, EGFR
219.1EGFR, BRAF
22
Hide members
9.1EGFR, BRAF
239.1BRAF, EGFR
24
Hide members
9.1EGFR, BRAF
259.1EGFR, BRAF
26
Hide members
9.1EGFR, BRAF
279.1EGFR, BRAF
289.1BRAF, EGFR
29
Hide members
9.1EGFR, BRAF
30
Hide members
9.1EGFR, BRAF
319.1EGFR, BRAF

Compounds for genes affiliated with Non-Small Cell Lung Carcinoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1panitumumab44 49 1111.4EGFR, BRAF
2cetuximab44 49 1111.4EGFR, BRAF
3sorafenib44 49 1111.4EGFR, BRAF
4irinotecan44 49 1111.4BRAF, EGFR
5geldanamycin44 49 59 1112.4EGFR, BRAF
6imatinib44 49 1111.4EGFR, BRAF
7agar449.3EGFR, BRAF
8sb 20358044 5910.3BRAF, EGFR
9paclitaxel44 49 1111.3EGFR, BRAF
10rapamycin449.2EGFR, BRAF
11pd 98,059449.2EGFR, BRAF
12ly294002449.1BRAF, EGFR
13cisplatin44 49 59 1112.1EGFR, BRAF
14phosphoinositide449.0EGFR, BRAF
15paraffin448.8EGFR, BRAF

GO Terms for genes affiliated with Non-Small Cell Lung Carcinoma

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16Gene Ontology
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Biological processes related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:0001869.1EGFR, BRAF
2neurotrophin TRK receptor signaling pathwayGO:0480119.1EGFR, BRAF
3positive regulation of ERK1 and ERK2 cascadeGO:0703749.0EGFR, BRAF
4fibroblast growth factor receptor signaling pathwayGO:0085438.8EGFR, BRAF

Molecular functions related to Non-Small Cell Lung Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1EGFR, BRAF

Products for genes affiliated with Non-Small Cell Lung Carcinoma

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  • Antibodies
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Sources for Non-Small Cell Lung Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet