Nonalcoholic Steatohepatitis (NASH) malady

Liver diseases category

Summaries for Nonalcoholic Steatohepatitis

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Nonalcoholic steatohepatitis, or nash, is a common, often “silent” liver disease. it resembles alcoholic liver disease, but occurs in people who drink little or no alcohol. the major feature in nash is fat in the liver, along with inflammation and damage. most people with nash feel well and are not aware that they have a liver problem. nevertheless, nash can be severe and can lead to cirrhosis, in which the liver is permanently damaged and scarred and no longer able to work properly. nash most often occurs in people who are middle aged and overweight or obese. affected individuals may also have elevated levels of blood lipids (such as cholesterol and triglycerides) and many have diabetes or prediabetes. treatment is centered around working towards a healthy lifestyle, including weight reduction, dietary modification, increased activity and avoidance of alcohol and unnecessary medications. the underlying cause of nash remains unclear. last updated: 2/24/2012

MalaCards: Nonalcoholic Steatohepatitis, also known as non-alcoholic fatty liver disease, is related to hepatitis and fatty liver disease. An important gene associated with Nonalcoholic Steatohepatitis is HFE (hemochromatosis), and among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Selected targets of HNF1. The compounds uric acid and fatty acid have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Aliases & Classifications for Nonalcoholic Steatohepatitis

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42NIH Rare Diseases, 60UMLS
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Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases

Aliases & Descriptions:

nonalcoholic steatohepatitis 42 60
non-alcoholic fatty liver disease 42 60
non-alcoholic steatohepatitis 42
nash 42

Related Diseases for Nonalcoholic Steatohepatitis

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17GeneCards, 18GeneDecks
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Diseases related to Nonalcoholic Steatohepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.6SLC17A5, GPT
2fatty liver disease31.4CYP2E1, SLC17A5, ADIPOQ
3obesity31.3ADIPOR2, ADIPOQ, GGT1, LSL, NR1H4, HFE
4hepatocellular carcinoma31.1KLRK1, CYP2E1, TXN, HFE, INS, GPT
5hepatitis c31.1ABCB7, GPT, CYP2E1, HFE, LSL, TXN
6diabetes mellitus30.9GLP1R, HFE, NR1H4, LSL, TXN, PCK2
7alcoholic hepatitis30.9KRT18, SLC17A5, GPT, GGT1
8liver cirrhosis30.8RETN, CYP2E1, HFE, LSL, GPT, ABCB7
9type 2 diabetes mellitus30.7ADIPOQ, GGT1, SLC17A5, LEP, GPT, LSL
10essential hypertension30.7RETN, ADIPOQ, INS, LEP
11alcoholic liver cirrhosis30.7HFE, GGT1, SLC17A5, LSL, CYP2E1, GPT
12hyperuricemia30.6GGT1, GPT, INS
13coronary artery disease30.6RETN, INS, ADIPOQ, TXN, HFE
14polycystic ovary syndrome30.6LSL, RETN, INS, LEP, ADIPOQ
16pancreatitis30.4CYP2E1, INS, SLC17A5, GGT1
17lipodystrophy30.4RETN, ADIPOQ, LEP, INS, LSL
18atherosclerosis30.4TXN, LSL, NR1H4, ADIPOR2, ADIPOQ, PTX3
19alcohol dependence30.4GGT1
20colorectal cancer30.4KRT18, CYP2E1, KLRK1, TXN
22primary biliary cirrhosis30.4SLC17A5, GPT, NR1H4, GGT1
23cholangitis30.4GGT1, GPT, SLC17A5
24glucose intolerance30.4ADIPOQ, LEP, GPT, INS, RETN, PCK2
25vascular disease30.4RETN, INS, ADIPOQ, NR1H4
26brain disease30.4SLC17A5, GPT, ABCB7
27celiac disease30.3HFE, KLRK1
29alzheimer's disease30.3INS, CYP2E1, TXN, GLP1R, HFE
30acute liver failure30.2SLC17A5, GPT
33porphyria cutanea tarda30.2HFE
35portal hypertension30.2GPT, RETN, SLC17A5, GGT1
36hypertension30.2INS, LEP, RETN, GGT1
37viral hepatitis30.2HFE, GPT, ABCB7, SLC17A5, KRT18, GGT1
38morbid obesity30.2LSL, RETN, INS, LEP, ADIPOQ
39cholangiocarcinoma30.2KRT18, GGT1
40autoimmune hepatitis30.2GPT, KRT18, GGT1, SLC17A5
41adenoma30.2KRT18, GGT1, HFE, INS
42hepatitis b30.2GPT, ABCB7, GGT1, SLC17A5
43acanthosis nigricans30.2ADIPOQ, INS, LEP
44breast cancer30.2NR1H4, INS, KRT18, ADIPOR2, TXN, CYP2E1
45leukemia29.9HFE, CYP2E1, KLRK1
46cholestasis29.9NR1H4, GPT, ABCB7, SLC17A5, GGT1
47liver disease11.0
48hepatitis a10.7
49ovarian disease10.4

Graphical network of the top 20 diseases related to Nonalcoholic Steatohepatitis:

Diseases related to nonalcoholic steatohepatitis

Clinical Features for Nonalcoholic Steatohepatitis

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Drugs & Therapeutics for Nonalcoholic Steatohepatitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Nonalcoholic Steatohepatitis

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Anatomical Context for Nonalcoholic Steatohepatitis

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MalaCards organs/tissues related to Nonalcoholic Steatohepatitis:


Animal Models for Nonalcoholic Steatohepatitis or affiliated genes

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MGI Mouse Phenotypes related to Nonalcoholic Steatohepatitis:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.4PTX3, GLP1R
2MP:000537010.3ADIPOR2, NR1H4, HFE, CYP2E1, RETN, INS
3MP:000537610.1RETN, CYP2E1, GLP1R, HFE, NR1H4, INS
4MP:001076810.1CYP2E1, HFE, NR1H4, TXN, KLRK1, INS
5MP:000537810.1NR1H4, HFE, INS, LEP, ABCB7, SLC17A5
6MP:00053879.9KLRK1, NR1H4, HFE, INS, IL13RA2, LEP

Publications for Nonalcoholic Steatohepatitis

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Genetic Variations for Nonalcoholic Steatohepatitis

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Expression for genes affiliated with Nonalcoholic Steatohepatitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nonalcoholic Steatohepatitis

Search GEO for disease gene expression data for Nonalcoholic Steatohepatitis.

Pathways for genes affiliated with Nonalcoholic Steatohepatitis

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52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology, 53Reactome
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Compounds for genes affiliated with Nonalcoholic Steatohepatitis

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 170)
idCompoundScoreTop Affiliating Genes
1uric acid44 2411.9ABCB7, HFE
2fatty acid4410.7SLC17A5, KRT18, PCK2, GLP1R, LSL
3glutamate4410.7ADIPOQ, ABCB7, PCK2, RETN, GPT
4beta-hydroxybutyrate4410.7LSL, LEP, ABCB7, SLC17A5, INS
5glucose4410.7NR1H4, LSL, GLP1R, ADIPOR2, KRT18, SLC17A5
6fenofibrate44 49 1112.7LEP, ADIPOQ, SLC17A5, GPT, INS, RETN
7ursodeoxycholic acid44 11 2412.7ABCB7, SLC17A5, NR1H4, CYP2E1, GPT, GGT1
8p0034410.7ADIPOR2, RETN, HFE, LSL
9bezafibrate44 28 1112.7INS, GPT, SLC17A5, GGT1, ADIPOQ
10c-peptide4410.7GLP1R, SLC17A5, LEP, INS, RETN, LSL
11thiazolidinedione4410.6ADIPOQ, LEP, INS, RETN, PCK2
12sibutramine44 1111.6LEP, INS, LSL, ADIPOQ
13pioglitazone44 49 28 1113.6GPT, ADIPOR2, ADIPOQ, GGT1, SLC17A5, LEP
14dhea4410.6LEP, NR1H4, ADIPOQ, RETN, LSL, INS
15troglitazone44 28 59 1113.6PCK2, SLC17A5, ADIPOQ, LEP, GPT, INS
16clozapine44 28 49 1113.6ADIPOQ, GGT1, LEP, LSL, CYP2E1, GPT
17metformin44 49 1112.6ADIPOQ, GGT1, SLC17A5, LEP, GPT, INS
18silymarin4410.6GGT1, ABCB7, GPT, CYP2E1, SLC17A5
19olanzapine49 44 28 11 2414.6ADIPOQ, LEP, INS, LSL, SLC17A5
20rosiglitazone44 49 28 11 2414.6PCK2, RETN, INS, GPT, ADIPOR2, ADIPOQ
21p0024410.6LSL, RETN, GPT, LEP, KRT18, ADIPOQ
22urea44 11 2412.6LSL, GGT1, KRT18, ABCB7, GPT, RETN
23acipimox44 2811.6INS, ADIPOQ, LSL, LEP
24fibrinogen4410.6LSL, GPT, RETN, ABCB7, KRT18, ADIPOQ
25ascorbic acid44 2411.6CYP2E1, ADIPOQ, LEP, GGT1, KRT18, SLC17A5
26nash4410.6INS, RETN, CYP2E1, HFE, LSL, GPT
27ethanol44 49 11 2413.6HFE, LSL, CYP2E1, GPT, ABCB7, SLC17A5
28thyroxine44 2411.6TXN, LSL, RETN, INS, GPT, LEP
29glycogen44 2411.6ABCB7, RETN, KRT18, ADIPOQ, SLC17A5, GPT
30vitamin a44 11 2412.6LEP, SLC17A5, GGT1, ADIPOQ, GPT, RETN
31nevirapine44 49 1112.6GPT, ABCB7, SLC17A5, GGT1
32dexamethasone44 49 28 1113.6TXN, PCK2, CYP2E1, RETN, ADIPOQ, PTX3
33sevoflurane44 1111.6SLC17A5, GPT, GGT1, CYP2E1
34betacarotene4410.5SLC17A5, CYP2E1, TXN, GGT1, LEP
35lactate4410.5GGT1, ADIPOQ, KRT18, SLC17A5, ABCB7, TXN
36aspartate4410.5ABCB7, SLC17A5, KRT18, GGT1, RETN, TXN
37creatinine4410.5LEP, ABCB7, SLC17A5, KRT18, GGT1, PTX3
38alanine4410.5INS, ABCB7, SLC17A5, KRT18, GGT1, RETN
39testosterone44 59 11 2413.5RETN, CYP2E1, HFE, NR1H4, LSL, TXN
40glycerol44 11 2412.5LEP, INS, CYP2E1, PCK2, ADIPOQ, LSL
41triacylglycerol4410.5INS, PCK2, LEP, ADIPOQ, LSL
42cholesterol44 28 11 2413.5ABCB7, LEP, GPT, INS, RETN, PCK2
43acetaminophen44 2 49 11 2414.5CYP2E1, GGT1, KRT18, SLC17A5, GPT
44arginine4410.4KLRK1, GPT, LEP, TXN, LSL, NR1H4
45lipid4410.4LEP, ABCB7, SLC17A5, KRT18, GGT1, ADIPOQ
46androstenedione44 2411.4LEP, INS, CYP2E1, LSL, ADIPOQ
47vitamin-e4410.3KRT18, GPT, ABCB7, GGT1, SLC17A5
48pravastatin44 49 28 11 2414.3LSL, GPT, LEP, ABCB7, ADIPOQ
49orlistat44 59 1112.3LSL, ADIPOQ, LEP, INS
50methotrexate44 49 1112.0LSL, ADIPOQ, GGT1, SLC17A5, LEP, GPT

GO Terms for genes affiliated with Nonalcoholic Steatohepatitis

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16Gene Ontology
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Biological processes related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin receptor signaling pathwayGO:04662810.5INS, LEP
2glucose metabolic processGO:00600610.5ADIPOQ, LEP, INS, PCK2
3negative regulation of gluconeogenesisGO:04572110.5ADIPOQ, INS
4fatty acid oxidationGO:01939510.4ADIPOR2, ADIPOQ
5regulation of insulin secretionGO:05079610.4LEP, INS, GLP1R
6small molecule metabolic processGO:04428110.3TXN, GLP1R, PCK2, CYP2E1, INS, GPT
7positive regulation of cellular protein metabolic processGO:03227010.3INS, ADIPOQ
8energy reserve metabolic processGO:00611210.1LEP, INS, GLP1R

Molecular functions related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.4ADIPOQ, LEP, INS, RETN

Products for genes affiliated with Nonalcoholic Steatohepatitis

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  • Antibodies
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Sources for Nonalcoholic Steatohepatitis

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26ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
61UMLS via Orphanet