NASH
MCID: NNL002
MIFTS: 50

Nonalcoholic Steatohepatitis (NASH) malady

Liver category

Summaries for Nonalcoholic Steatohepatitis

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Nonalcoholic steatohepatitis, or nash, is a common, often “silent” liver disease. it resembles alcoholic liver disease, but occurs in people who drink little or no alcohol. the major feature in nash is fat in the liver, along with inflammation and damage. most people with nash feel well and are not aware that they have a liver problem. nevertheless, nash can be severe and can lead to cirrhosis, in which the liver is permanently damaged and scarred and no longer able to work properly. nash most often occurs in people who are middle aged and overweight or obese. affected individuals may also have elevated levels of blood lipids (such as cholesterol and triglycerides) and many have diabetes or prediabetes. treatment is centered around working towards a healthy lifestyle, including weight reduction, dietary modification, increased activity and avoidance of alcohol and unnecessary medications. the underlying cause of nash remains unclear. last updated: 2/24/2012

MalaCards: Nonalcoholic Steatohepatitis, also known as non-alcoholic fatty liver disease, is related to fatty liver disease and insulin resistance. An important gene associated with Nonalcoholic Steatohepatitis is HFE (hemochromatosis), and among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Selected targets of HNF1. The compounds uric acid and fatty acid have been mentioned in the context of this disorder. Affiliated tissues include small intestine, kidney and liver, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Aliases & Classifications for Nonalcoholic Steatohepatitis

Sources:
43NIH Rare Diseases, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver


Aliases & Descriptions:

nonalcoholic steatohepatitis 43 61
non-alcoholic fatty liver disease 43 61
non-alcoholic steatohepatitis 43
nash 43


Related Diseases for Nonalcoholic Steatohepatitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Nonalcoholic Steatohepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1fatty liver disease31.4CYP2E1, SLC17A5, ADIPOQ
2insulin resistance31.2GPT, LEP, SLC17A5, GGT1, ADIPOQ, ADIPOR2
3hepatitis c31.1ABCB7, GPT, CYP2E1, HFE, LSL, TXN
4alcoholic hepatitis30.9KRT18, SLC17A5, GPT, GGT1
5alcoholic liver cirrhosis30.7HFE, GGT1, SLC17A5, LSL, CYP2E1, GPT
6hepatitis e30.7GPT
7hyperuricemia30.7GGT1, GPT, INS
8coronary artery disease,30.7RETN, INS, ADIPOQ, TXN, HFE
9polycystic ovary syndrome30.6LSL, RETN, INS, LEP, ADIPOQ
10hepatitis b30.5GPT, ABCB7, GGT1, SLC17A5
11atherosclerosis30.5TXN, LSL, NR1H4, ADIPOR2, ADIPOQ, PTX3
12colorectal cancer30.4KRT18, CYP2E1, KLRK1, TXN
13hyperhomocysteinemia30.4TXN
14coronary heart disease30.4ADIPOQ, LEP, INS, HFE, RETN, GGT1
15primary biliary cirrhosis30.4SLC17A5, GPT, NR1H4, GGT1
16glucose intolerance30.4ADIPOQ, LEP, GPT, INS, RETN, PCK2
17vascular disease30.4RETN, INS, ADIPOQ, NR1H4
18brain disease30.4SLC17A5, GPT, ABCB7
19celiac disease30.3HFE, KLRK1
20alzheimer's disease30.3INS, CYP2E1, TXN, GLP1R, HFE
21acute liver failure30.3SLC17A5, GPT
22porphyria cutanea tarda30.2HFE
23hemochromatosis30.2HFE
24portal hypertension30.2GPT, RETN, SLC17A5, GGT1
25viral hepatitis30.2HFE, GPT, ABCB7, SLC17A5, KRT18, GGT1
26morbid obesity30.2LSL, RETN, INS, LEP, ADIPOQ
27autoimmune hepatitis30.2GPT, KRT18, GGT1, SLC17A5
28adenoma30.2KRT18, GGT1, HFE, INS
29growth hormone deficiency30.2LEP, LSL, INS, ADIPOQ
30acanthosis nigricans30.2ADIPOQ, INS, LEP
31wilson disease30.2SLC17A5, GPT, HFE
32n syndrome10.8
33hepatitis a10.7
34hepatitis d10.5
35nutrition disease10.5
36lip disease10.4
37non-a-e hepatitis10.3
38hepatitis c virus10.3
39familial mediterranean fever10.3
40siderosis10.3
41irritable bowel syndrome10.3
42sclerosing cholangitis10.3
43bladder disease10.3
44primary sclerosing cholangitis10.3
45insulin-resistance type b10.3
46cardiovascular disease risk factor10.3
47m�ni�re disease10.3
48autonomic dysfunction10.3
49obesity, variation in10.3
50hypertension, diastolic10.3

Graphical network of the top 20 diseases related to Nonalcoholic Steatohepatitis:



Diseases related to nonalcoholic steatohepatitis

Clinical Features for Nonalcoholic Steatohepatitis

Drugs & Therapeutics for Nonalcoholic Steatohepatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nonalcoholic Steatohepatitis

Drug clinical trials:

Search ClinicalTrials for Nonalcoholic Steatohepatitis

Search NIH Clinical Center for Nonalcoholic Steatohepatitis

Search CenterWatch for Nonalcoholic Steatohepatitis

Genetic Tests for Nonalcoholic Steatohepatitis

Anatomical Context for Nonalcoholic Steatohepatitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Nonalcoholic Steatohepatitis:

33
Small intestine, Kidney, Liver, Thyroid, Breast, Ovary, Myeloid, T cells, B cells, Endothelial, Fetal liver, Fetal thyroid

Animal Models for Nonalcoholic Steatohepatitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Nonalcoholic Steatohepatitis

Sources:
51PubMed
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Articles related to Nonalcoholic Steatohepatitis:

(show top 50)    (show all 629)
idTitleAuthorsYear
1
Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes. (24375162)
2014
2
Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression. (24403518)
2014
3
Validation of terminal peptide of procollagen III for the detection and assessment of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease. (22930399)
2013
4
Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice. (23322710)
2013
5
Dietary treatment of nonalcoholic steatohepatitis. (23283181)
2013
6
Probucol ameliorates the development of nonalcoholic steatohepatitis in rats fed high-fat diets. (22878918)
2013
7
A case report of massive vaginal variceal hemorrhage in a patient with cirrhosis secondary to nonalcoholic steatohepatitis unresolved even after successful liver transplantation. (23267803)
2013
8
Usefulness of Gd-EOB-DTPA-enhanced MR imaging in the evaluation of simple steatosis and nonalcoholic steatohepatitis. (23172731)
2013
9
Increased hepatic oxidative DNA damage in patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. (23329365)
2013
10
Evolving aspects of liver transplantation for nonalcoholic steatohepatitis. (23652610)
2013
11
Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. (23592516)
2013
12
Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis. (23299969)
2013
13
Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis. (24157968)
2013
14
Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. (22326434)
2012
15
Intragastric balloon significantly improves nonalcoholic fatty liver disease activity score in obese patients with nonalcoholic steatohepatitis: a pilot study. (22840293)
2012
16
Reducing the load: the evolution and management of obesity and nonalcoholic steatohepatitis before liver transplantation. (22821716)
2012
17
Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis. (21745271)
2011
18
Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation. (21327395)
2011
19
A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis. (21145828)
2011
20
Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis. (21906580)
2011
21
Risk of nonalcoholic steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease and low visceral adiposity. (21145841)
2011
22
Nonalcoholic fatty liver disease activity score and Brunt's pathologic criteria for the diagnosis of nonalcoholic steatohepatitis: what do they mean and do they agree? (21618266)
2011
23
Major histocompatibility complex class I-related chains A and B (MIC A/B): a novel role in nonalcoholic steatohepatitis. (19998387)
2010
24
PPARgamma is essential for protection against nonalcoholic steatohepatitis. (20376096)
2010
25
Effects of docosahexaenoic acid in an experimental rat model of nonalcoholic steatohepatitis. (20625232)
2010
26
Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. (20631297)
2010
27
Thiazolidinedione therapy for nonalcoholic steatohepatitis: go, stop, or proceed with caution? (20101743)
2010
28
High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. (20607689)
2010
29
Adipokines in nonalcoholic steatohepatitis. (19968779)
2010
30
Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice. (20206177)
2010
31
Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease. (19938128)
2009
32
Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. (19637190)
2009
33
The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: two triggers for one disease? (19440711)
2009
34
Adipose tissue transplantation may be a potential treatment for diabetes, atherosclerosis and nonalcoholic steatohepatitis. (19046821)
2009
35
Adipokines in nonalcoholic steatohepatitis: from pathogenesis to implications in diagnosis and therapy. (19753129)
2009
36
Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis. (19672551)
2009
37
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. (19065650)
2009
38
Beneficial effects of Vitis coignetiae Pulliat leaves on nonalcoholic steatohepatitis in a rat model. (19404342)
2009
39
Adipohormones as prognostric markers in patients with nonalcoholic steatohepatitis (NASH). (19996485)
2009
40
Does the hormone of eternal youth protect against nonalcoholic steatohepatitis? (18792129)
2008
41
Multiple inflammatory and serum amyloid A positive telangiectatic hepatic adenomas with glycogenated nuclei arising in a background of nonalcoholic steatohepatitis. (18956299)
2008
42
Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice. (18848945)
2008
43
A comparison of treatments offered to patients with nonalcoholic steatohepatitis. (19032886)
2008
44
HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis. (17680648)
2007
45
High-fat emulsion-induced rat model of nonalcoholic steatohepatitis. (16624332)
2006
46
Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. (12717402)
2003
47
The risk factors of fibrosis in nonalcoholic steatohepatitis. (15526543)
2002
48
A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis. (11232700)
2001
49
Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. (11732005)
2001
50
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. (11266382)
2001

Genetic Variations for Nonalcoholic Steatohepatitis

Expression for genes affiliated with Nonalcoholic Steatohepatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Nonalcoholic Steatohepatitis

Search GEO for disease gene expression data for Nonalcoholic Steatohepatitis.

Pathways for genes affiliated with Nonalcoholic Steatohepatitis

Sources:
53R&D Systems, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology, 54Reactome
See all sources

Compounds for genes affiliated with Nonalcoholic Steatohepatitis

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 170)
idCompoundScoreTop Affiliating Genes
1uric acid45 2411.9ABCB7, HFE
2fatty acid4510.7SLC17A5, KRT18, PCK2, GLP1R, LSL
3glutamate4510.7ADIPOQ, ABCB7, PCK2, RETN, GPT
4beta-hydroxybutyrate4510.7LSL, LEP, ABCB7, SLC17A5, INS
5glucose4510.7NR1H4, LSL, GLP1R, ADIPOR2, KRT18, SLC17A5
6fenofibrate45 50 1112.7LEP, ADIPOQ, SLC17A5, GPT, INS, RETN
7ursodeoxycholic acid45 11 2412.7ABCB7, SLC17A5, NR1H4, CYP2E1, GPT, GGT1
8p0034510.7ADIPOR2, RETN, HFE, LSL
9bezafibrate45 29 1112.7INS, GPT, SLC17A5, GGT1, ADIPOQ
10c-peptide4510.7GLP1R, SLC17A5, LEP, INS, RETN, LSL
11thiazolidinedione4510.6ADIPOQ, LEP, INS, RETN, PCK2
12sibutramine45 1111.6LEP, INS, LSL, ADIPOQ
13pioglitazone45 50 29 1113.6GPT, ADIPOR2, ADIPOQ, GGT1, SLC17A5, LEP
14dhea4510.6LEP, NR1H4, ADIPOQ, RETN, LSL, INS
15troglitazone45 29 60 1113.6PCK2, SLC17A5, ADIPOQ, LEP, GPT, INS
16clozapine45 29 50 1113.6ADIPOQ, GGT1, LEP, LSL, CYP2E1, GPT
17metformin45 50 1112.6ADIPOQ, GGT1, SLC17A5, LEP, GPT, INS
18silymarin4510.6GGT1, ABCB7, GPT, CYP2E1, SLC17A5
19olanzapine50 45 29 11 2414.6ADIPOQ, LEP, INS, LSL, SLC17A5
20rosiglitazone45 50 29 11 2414.6PCK2, RETN, INS, GPT, ADIPOR2, ADIPOQ
21p0024510.6LSL, RETN, GPT, LEP, KRT18, ADIPOQ
22urea45 11 2412.6LSL, GGT1, KRT18, ABCB7, GPT, RETN
23acipimox45 2911.6INS, ADIPOQ, LSL, LEP
24fibrinogen4510.6LSL, GPT, RETN, ABCB7, KRT18, ADIPOQ
25ascorbic acid45 2411.6CYP2E1, ADIPOQ, LEP, GGT1, KRT18, SLC17A5
26nash4510.6INS, RETN, CYP2E1, HFE, LSL, GPT
27ethanol45 50 11 2413.6HFE, LSL, CYP2E1, GPT, ABCB7, SLC17A5
28thyroxine45 2411.6TXN, LSL, RETN, INS, GPT, LEP
29glycogen45 2411.6ABCB7, RETN, KRT18, ADIPOQ, SLC17A5, GPT
30vitamin a45 11 2412.6LEP, SLC17A5, GGT1, ADIPOQ, GPT, RETN
31nevirapine45 50 1112.6GPT, ABCB7, SLC17A5, GGT1
32dexamethasone45 50 29 1113.6TXN, PCK2, CYP2E1, RETN, ADIPOQ, PTX3
33sevoflurane45 1111.6SLC17A5, GPT, GGT1, CYP2E1
34betacarotene4510.5SLC17A5, CYP2E1, TXN, GGT1, LEP
35lactate4510.5GGT1, ADIPOQ, KRT18, SLC17A5, ABCB7, TXN
36aspartate4510.5ABCB7, SLC17A5, KRT18, GGT1, RETN, TXN
37creatinine4510.5LEP, ABCB7, SLC17A5, KRT18, GGT1, PTX3
38alanine4510.5INS, ABCB7, SLC17A5, KRT18, GGT1, RETN
39testosterone45 60 11 2413.5RETN, CYP2E1, HFE, NR1H4, LSL, TXN
40glycerol45 11 2412.5LEP, INS, CYP2E1, PCK2, ADIPOQ, LSL
41triacylglycerol4510.5INS, PCK2, LEP, ADIPOQ, LSL
42cholesterol45 29 11 2413.5ABCB7, LEP, GPT, INS, RETN, PCK2
43acetaminophen45 2 50 11 2414.5CYP2E1, GGT1, KRT18, SLC17A5, GPT
44arginine4510.4KLRK1, GPT, LEP, TXN, LSL, NR1H4
45lipid4510.4LEP, ABCB7, SLC17A5, KRT18, GGT1, ADIPOQ
46androstenedione45 2411.4LEP, INS, CYP2E1, LSL, ADIPOQ
47vitamin-e4510.3KRT18, GPT, ABCB7, GGT1, SLC17A5
48pravastatin45 50 29 11 2414.3LSL, GPT, LEP, ABCB7, ADIPOQ
49orlistat45 60 1112.3LSL, ADIPOQ, LEP, INS
50methotrexate45 50 1112.0LSL, ADIPOQ, GGT1, SLC17A5, LEP, GPT

GO Terms for genes affiliated with Nonalcoholic Steatohepatitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin receptor signaling pathwayGO:04662810.5INS, LEP
2glucose metabolic processGO:00600610.5ADIPOQ, LEP, INS, PCK2
3negative regulation of gluconeogenesisGO:04572110.5ADIPOQ, INS
4fatty acid oxidationGO:01939510.4ADIPOR2, ADIPOQ
5regulation of insulin secretionGO:05079610.4INS, LEP, GLP1R
6small molecule metabolic processGO:04428110.3GPT, INS, CYP2E1, PCK2, GLP1R, TXN
7positive regulation of cellular protein metabolic processGO:03227010.3ADIPOQ, INS
8energy reserve metabolic processGO:00611210.1LEP, INS, GLP1R

Molecular functions related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.4ADIPOQ, LEP, INS, RETN

Products for genes affiliated with Nonalcoholic Steatohepatitis

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Sources for Nonalcoholic Steatohepatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet