MCID: NNL002
MIFTS: 45

Nonalcoholic Steatohepatitis malady

Rare diseases, Liver diseases categories

Summaries for Nonalcoholic Steatohepatitis

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NIH Rare Diseases:41 Nonalcoholic steatohepatitis, or nash, is a common, often “silent” liver disease. it resembles alcoholic liver disease, but occurs in people who drink little or no alcohol. the major feature in nash is fat in the liver, along with inflammation and damage. most people with nash feel well and are not aware that they have a liver problem. nevertheless, nash can be severe and can lead to cirrhosis, in which the liver is permanently damaged and scarred and no longer able to work properly. nash most often occurs in people who are middle aged and overweight or obese. affected individuals may also have elevated levels of blood lipids (such as cholesterol and triglycerides) and many have diabetes or prediabetes. treatment is centered around working towards a healthy lifestyle, including weight reduction, dietary modification, increased activity and avoidance of alcohol and unnecessary medications. the underlying cause of nash remains unclear. last updated: 2/24/2012

MalaCards based summary: Nonalcoholic Steatohepatitis, also known as non-alcoholic fatty liver disease, is related to hepatitis and fatty liver disease. An important gene associated with Nonalcoholic Steatohepatitis is SLC17A5 (solute carrier family 17 (acidic sugar transporter), member 5), and among its related pathways are Signaling events mediated by PTP1B and Selected targets of C EBPbeta. The compounds beta-hydroxybutyrate and stavudine have been mentioned in the context of this disorder. Affiliated tissues include liver, ovary and testes, and related mouse phenotypes are adipose tissue and cellular.

Aliases & Classifications for Nonalcoholic Steatohepatitis

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Nonalcoholic Steatohepatitis, Aliases & Descriptions:

Name: Nonalcoholic Steatohepatitis 41 60
Non-Alcoholic Fatty Liver Disease 41 60
 
Non-Alcoholic Steatohepatitis 41
Nash 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Liver diseases


Related Diseases for Nonalcoholic Steatohepatitis

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Diseases related to Nonalcoholic Steatohepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.6CYP2E1, GPT, HFE, SLC17A5
2fatty liver disease31.4CYP2E1, ADIPOQ, SLC17A5
3alcoholic hepatitis31.1GPT, KRT18, SLC17A5
4hyperuricemia31.0GPT, INS
5liver disease31.0CYP2E1, KRT18, HFE, LEP, INS
6siderosis31.0GPT, HFE
7cholangitis30.9SLC17A5, GPT
8acute liver failure30.9SLC17A5, GPT
9polycystic ovary syndrome30.9INS, LEP
10hypopituitarism30.8LEP, INS
11obstructive sleep apnea30.8LEP, ADIPOQ
12hepatitis c30.8CYP2E1, GPT, HFE, KRT18, SLC17A5
13portal hypertension30.7GPT, RETN, SLC17A5
14pancreatitis30.7CYP2E1, INS, SLC17A5
15hepatitis b30.6SLC17A5, GPT
16autoimmune hepatitis30.6GPT, KRT18, SLC17A5
17morbid obesity30.6LEP, INS
18hepatocellular carcinoma30.5CYP2E1, GPT, INS, HFE, KRT18, SLC17A5
19viral hepatitis30.4GPT, HFE, KRT18, SLC17A5
20acanthosis nigricans30.3ADIPOQ, LEP, INS
21lipodystrophy30.3INS, LEP, ADIPOQ, RETN
22growth hormone deficiency30.3INS, LEP, ADIPOQ
23atherosclerosis30.3INS, LEP, ADIPOQ, RETN
24alcoholic liver cirrhosis30.2CYP2E1, GPT, HFE, SLC17A5
25coronary artery disease30.0INS, ADIPOR1, ADIPOQ, RETN, HFE
26glucose intolerance30.0RETN, ADIPOQ, LEP, INS, GPT
27obesity29.7ADIPOQ, ADIPOR1, LEP, INS, GPT, CYP2E1
28breast cancer29.4CYP2E1, INS, LEP, ADIPOR1, KRT18
29liver cirrhosis29.2CYP2E1, GPT, ADIPOQ, RETN, HFE, KRT18
30hepatitis c virus10.6
31fascioliasis10.5SLC17A5
32rabson-mendenhall syndrome10.5INS
33autonomic dysfunction10.5
34blindness10.5
35pyridoxine deficiency10.4SLC17A5, GPT
36ischemia10.4
37sleep apnea10.4
38vaginitis10.4
39obstructive jaundice10.4GPT, SLC17A5
40choledocholithiasis10.4SLC17A5, GPT
41hellp syndrome10.4GPT, SLC17A5
42scrub typhus10.3GPT, SLC17A5
43hepatic encephalopathy10.3GPT, SLC17A5
44bilirubin metabolic disorder10.3GPT, SLC17A5
45splenomegaly10.3GPT, SLC17A5
46adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency10.3SLC17A5, GPT
47colorectal cancer10.3
48pulmonary function10.3
49primary biliary cirrhosis10.3
50hyperhomocysteinemia10.3

Graphical network of the top 20 diseases related to Nonalcoholic Steatohepatitis:



Diseases related to nonalcoholic steatohepatitis

Symptoms for Nonalcoholic Steatohepatitis

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Drugs & Therapeutics for Nonalcoholic Steatohepatitis

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Drug clinical trials:

Search ClinicalTrials for Nonalcoholic Steatohepatitis

Search NIH Clinical Center for Nonalcoholic Steatohepatitis

Genetic Tests for Nonalcoholic Steatohepatitis

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Anatomical Context for Nonalcoholic Steatohepatitis

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MalaCards organs/tissues related to Nonalcoholic Steatohepatitis:

31
Liver, Ovary, Testes, Small intestine, Kidney, T cells, Bone, Thyroid, Breast, Myeloid, Endothelial

Animal Models for Nonalcoholic Steatohepatitis or affiliated genes

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MGI Mouse Phenotypes related to Nonalcoholic Steatohepatitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.1INS, LEP, ADIPOR1, ADIPOQ, RETN
2MP:00053847.8SLC17A5, HFE, ADIPOQ, ADIPOR1, LEP, INS
3MP:00053787.2INS, LEP, ADIPOR1, ADIPOQ, HFE, KRT18
4MP:00053867.0CYP2E1, INS, LEP, ADIPOR1, ADIPOQ, HFE
5MP:00107686.7CYP2E1, INS, LEP, ADIPOQ, HFE, KRT18
6MP:00053766.7CYP2E1, INS, LEP, ADIPOR1, ADIPOQ, RETN
7MP:00053706.6KRT18, CYP2E1, INS, LEP, ADIPOR1, ADIPOQ

Publications for Nonalcoholic Steatohepatitis

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Articles related to Nonalcoholic Steatohepatitis:

(show top 50)    (show all 654)
idTitleAuthorsYear
1
Weight Loss via Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis. (25865049)
2015
2
P2X7 Receptor as a Key Player in Oxidative Stress-Driven Cell Fate in Nonalcoholic Steatohepatitis. (25815106)
2015
3
High-fat diet decreases activity of the oxidative phosphorylation complexes and causes nonalcoholic steatohepatitis in mice. (25261569)
2014
4
Complement alternative pathway activation in human nonalcoholic steatohepatitis. (25299043)
2014
5
Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes. (24375162)
2014
6
Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. (23832448)
2014
7
Modeling Human Nonalcoholic Steatohepatitis-Associated Changes in Drug Transporter Expression Using Experimental Rodent Models. (24384915)
2014
8
Author reply: comment to "atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-I+-lowering property". (22909420)
2013
9
Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis. (24066058)
2013
10
Immune therapy for nonalcoholic steatohepatitis: are we there yet? (23442833)
2013
11
Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. (23640861)
2013
12
Cytokeratin 18, alanine aminotransferase, platelets and triglycerides predict the presence of nonalcoholic steatohepatitis. (24324749)
2013
13
Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. (22915297)
2012
14
The effects of long-term melatonin treatment on plasma liver enzymes levels and plasma concentrations of lipids and melatonin in patients with nonalcoholic steatohepatitis: a pilot study. (22460459)
2012
15
Liver: new biomarker identified for nonalcoholic steatohepatitis. (22371214)
2012
16
Nonalcoholic steatohepatitis versus steatosis: adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism. (22684858)
2012
17
Excellent posttransplant survival for patients with nonalcoholic steatohepatitis in the United States. (21932374)
2012
18
Noninvasive clinical model for the diagnosis of nonalcoholic steatohepatitis in overweight and morbidly obese patients undergoing bariatric surgery. (23294957)
2012
19
Serologic predictors of nonalcoholic steatohepatitis in a population undergoing bariatric surgery. (21865094)
2012
20
Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-I+ production. (23066023)
2012
21
Centrizonal arteries and microvessels in nonalcoholic steatohepatitis. (21836480)
2011
22
Adiponectin suppresses endoplasmic reticulum stress in nonalcoholic steatohepatitis. (22977616)
2011
23
Osteopontin: a missing link between hedgehog signaling and fibrosis in nonalcoholic steatohepatitis. (21274859)
2011
24
Major histocompatibility complex class I-related chains A and B (MIC A/B): a novel role in nonalcoholic steatohepatitis. (19998387)
2010
25
Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis. (20556839)
2010
26
Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice. (20566747)
2010
27
Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content. (20357081)
2010
28
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. (19914374)
2010
29
Serum cytokeratin-18 fragment level: a noninvasive biomarker for not only nonalcoholic steatohepatitis, but also alcoholic steatohepatitis. (20041411)
2010
30
PPARgamma is essential for protection against nonalcoholic steatohepatitis. (20376096)
2010
31
Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgery. (19573756)
2009
32
Assessment of hepatic steatosis and hepatic tissue blood flow by xenon computed tomography in nonalcoholic steatohepatitis. (18761681)
2009
33
Wilson's disease masquerading as nonalcoholic steatohepatitis. (22666674)
2009
34
Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease. (19938128)
2009
35
Biomarkers for noninvasive biochemical diagnosis of nonalcoholic steatohepatitis: tools or decorations? (19750583)
2009
36
Treatment of nonalcoholic steatohepatitis with colestimide. (19473432)
2009
37
Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis. (19422479)
2009
38
Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis. (19424798)
2009
39
Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. (19637190)
2009
40
Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver. (19141695)
2009
41
A rabbit model of pediatric nonalcoholic steatohepatitis: the role of adiponectin. (19248189)
2009
42
Imaging of nonalcoholic steatohepatitis: advantages and pitfalls of ultrasonography and computed tomography. (19443967)
2009
43
Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats. (19004024)
2009
44
Nonalcoholic steatohepatitis: pathogenesis and treatment]. (18367854)
2008
45
Decreased phagocytic activity of Kupffer cells in a rat nonalcoholic steatohepatitis model. (18932283)
2008
46
HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis. (17680648)
2007
47
Nonalcoholic steatohepatitis in obese children: the prevalence and possible mechanism]. (16470923)
2006
48
Elevated urine neopterin levels in nonalcoholic steatohepatitis. (15642284)
2005
49
Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. (14512888)
2003
50
Nonalcoholic steatohepatitis. Clinicopathological comparison with alcoholic hepatitis in ambulatory and hospitalized patients. (8565753)
1996

Variations for Nonalcoholic Steatohepatitis

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Expression for genes affiliated with Nonalcoholic Steatohepatitis

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Search GEO for disease gene expression data for Nonalcoholic Steatohepatitis.

Pathways for genes affiliated with Nonalcoholic Steatohepatitis

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Compounds for genes affiliated with Nonalcoholic Steatohepatitis

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Compounds related to Nonalcoholic Steatohepatitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1beta-hydroxybutyrate439.5SLC17A5, LEP, INS
2stavudine43 1210.2ADIPOQ, LEP, GPT
3sibutramine43 1210.2LEP, ADIPOQ, INS
4ezetimibe43 1210.2ADIPOQ, INS, GPT, SLC17A5
5glimepiride43 49 1211.2INS, ADIPOQ, RETN
6rosuvastatin43 49 28 1212.2INS, GPT, SLC17A5, ADIPOQ
7bezafibrate43 28 1211.1ADIPOQ, INS, GPT, SLC17A5
8acipimox43 2810.1ADIPOQ, INS, LEP
9urea43 24 1211.1GPT, RETN, KRT18, SLC17A5
10lamivudine43 49 1211.1GPT, LEP, SLC17A5, ADIPOQ
11atorvastatin43 49 28 24 1213.0GPT, ADIPOQ, RETN, SLC17A5
12olanzapine43 49 28 24 1212.9LEP, INS, ADIPOQ, SLC17A5
13telmisartan43 28 1210.9LEP, INS, ADIPOQ
14thiazolidinedione438.9ADIPOQ, INS, LEP, RETN
15sevoflurane49 43 1210.9SLC17A5, GPT, CYP2E1
168-isoprostane438.9INS, ADIPOQ, LEP, RETN
17dhea438.9INS, LEP, RETN, ADIPOQ
18acetaminophen43 2 49 24 1212.9SLC17A5, GPT, KRT18, CYP2E1
19troglitazone43 28 59 1211.7GPT, INS, LEP, ADIPOQ, SLC17A5
20ethanol43 49 24 1211.5HFE, CYP2E1, SLC17A5, KRT18, GPT
21p003438.5LEP, HFE, ADIPOQ, RETN, ADIPOR1
22norepinephrine43 24 1210.5ADIPOQ, LEP, RETN, INS, SLC17A5
23androstenedione43 249.4CYP2E1, INS, LEP, ADIPOQ
24aspartate438.4KRT18, RETN, HFE, GPT, SLC17A5, ADIPOQ
25cocaine43 129.4LEP, SLC17A5, ADIPOQ, GPT
26clozapine43 28 49 1211.4ADIPOQ, LEP, GPT, CYP2E1
27glycogen43 249.4ADIPOQ, GPT, INS, KRT18, RETN, SLC17A5
28fenofibrate43 49 1210.3GPT, SLC17A5, ADIPOQ, INS, RETN, LEP
29metformin43 49 1210.3INS, SLC17A5, GPT, LEP, ADIPOQ, RETN
30thyroxine43 249.3LEP, ADIPOQ, RETN, INS, GPT, SLC17A5
31c-peptide438.2INS, SLC17A5, ADIPOQ, LEP, RETN, ADIPOR1
32p002438.1ADIPOR1, LEP, GPT, RETN, KRT18, ADIPOQ
33uric acid43 249.0HFE, RETN, ADIPOQ, LEP, SLC17A5, INS
34alanine438.0HFE, KRT18, SLC17A5, RETN, ADIPOQ, INS
35vitamin a43 24 129.9GPT, CYP2E1, LEP, SLC17A5, ADIPOQ, RETN
36lactate437.9INS, GPT, CYP2E1, KRT18, SLC17A5, ADIPOQ
37fibrinogen437.9RETN, INS, GPT, LEP, ADIPOQ, KRT18
38ascorbic acid43 248.8KRT18, CYP2E1, LEP, SLC17A5, ADIPOQ, HFE
39pioglitazone28 43 49 1210.8LEP, ADIPOR1, ADIPOQ, SLC17A5, INS, GPT
40glutamate437.8KRT18, GPT, LEP, SLC17A5, RETN, ADIPOQ
41rosiglitazone28 43 49 24 1211.8RETN, GPT, INS, LEP, ADIPOR1, ADIPOQ
42estrogen437.8KRT18, INS, HFE, LEP, ADIPOQ, RETN
43fatty acid437.7RETN, SLC17A5, KRT18, ADIPOQ, ADIPOR1, LEP
44dexamethasone43 49 28 1210.5ADIPOQ, KRT18, RETN, CYP2E1, INS, LEP
45cholesterol43 28 24 1210.5SLC17A5, INS, GPT, ADIPOR1, LEP, ADIPOQ
46creatinine437.1KRT18, ADIPOQ, SLC17A5, RETN, LEP, INS
47glucose437.0HFE, GPT, LEP, INS, ADIPOR1, ADIPOQ
48nash436.8CYP2E1, KRT18, HFE, RETN, ADIPOQ, LEP
49testosterone43 59 24 129.6CYP2E1, SLC17A5, KRT18, RETN, HFE, ADIPOQ
50lipid436.2GPT, SLC17A5, KRT18, ADIPOQ, LEP, RETN

GO Terms for genes affiliated with Nonalcoholic Steatohepatitis

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Cellular components related to Nonalcoholic Steatohepatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5RETN, ADIPOQ, LEP, INS

Biological processes related to Nonalcoholic Steatohepatitis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of feeding behaviorGO:020002529.9RETN, INS
2leptin-mediated signaling pathwayGO:00332109.7ADIPOR1, LEP
3negative regulation of gluconeogenesisGO:00457219.6ADIPOQ, INS
4positive regulation of cellular protein metabolic processGO:00322709.6ADIPOQ, INS
5adiponectin-activated signaling pathwayGO:00332119.6ADIPOR1, ADIPOQ
6positive regulation of MAPK cascadeGO:00434109.5LEP, INS
7positive regulation of glucose importGO:00463269.4INS, ADIPOQ
8fatty acid oxidationGO:00193959.4ADIPOQ, ADIPOR1
9response to insulinGO:00328689.3RETN, LEP
10positive regulation of insulin receptor signaling pathwayGO:00466289.3ADIPOR1, LEP, INS
11circadian rhythmGO:00076239.2ADIPOQ, LEP
12glucose metabolic processGO:00060069.1INS, LEP, ADIPOQ

Molecular functions related to Nonalcoholic Steatohepatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051798.5RETN, ADIPOQ, LEP, INS

Products for genes affiliated with Nonalcoholic Steatohepatitis

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Sources for Nonalcoholic Steatohepatitis

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3CDC
13ExPASy
14FMA
22GTR
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet