NASH
MCID: NNL002
MIFTS: 52

Nonalcoholic Steatohepatitis (NASH) malady

Rare diseases, Liver diseases categories

Summaries for Nonalcoholic Steatohepatitis

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44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Nonalcoholic steatohepatitis, or nash, is a common, often “silent” liver disease. it resembles alcoholic liver disease, but occurs in people who drink little or no alcohol. the major feature in nash is fat in the liver, along with inflammation and damage. most people with nash feel well and are not aware that they have a liver problem. nevertheless, nash can be severe and can lead to cirrhosis, in which the liver is permanently damaged and scarred and no longer able to work properly. nash most often occurs in people who are middle aged and overweight or obese. affected individuals may also have elevated levels of blood lipids (such as cholesterol and triglycerides) and many have diabetes or prediabetes. treatment is centered around working towards a healthy lifestyle, including weight reduction, dietary modification, increased activity and avoidance of alcohol and unnecessary medications. the underlying cause of nash remains unclear. last updated: 2/24/2012

MalaCards: Nonalcoholic Steatohepatitis, also known as non-alcoholic fatty liver disease, is related to hepatitis and fatty liver disease. An important gene associated with Nonalcoholic Steatohepatitis is SLC17A5 (solute carrier family 17 (acidic sugar transporter), member 5), and among its related pathways are Signaling events mediated by PTP1B and Selected targets of C EBPbeta. The compounds beta-hydroxybutyrate and stavudine have been mentioned in the context of this disorder. Affiliated tissues include liver, ovary and testes, and related mouse phenotypes are adipose tissue and cellular.

Aliases & Classifications for Nonalcoholic Steatohepatitis

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Liver diseases


Aliases & Descriptions:

nonalcoholic steatohepatitis 44 63
non-alcoholic fatty liver disease 44 63
non-alcoholic steatohepatitis 44
nash 44


Related Diseases for Nonalcoholic Steatohepatitis

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18GeneCards, 19GeneDecks
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Diseases related to Nonalcoholic Steatohepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.8SLC17A5, GPT
2fatty liver disease31.4CYP2E1, ADIPOQ, SLC17A5
3hepatitis c31.1CYP2E1, GPT, HFE, SLC17A5, KRT18
4hepatocellular carcinoma31.1INS, CYP2E1, GPT, KRT18, SLC17A5, HFE
5obesity31.0CYP2E1, GPT, INS, LEP, ADIPOR1, ADIPOQ
6insulin resistance30.9CYP2E1, GPT, INS, LEP, ADIPOR1, ADIPOQ
7alcoholic hepatitis30.9GPT, KRT18, SLC17A5
8hyperuricemia30.7INS, GPT
9essential hypertension30.7ADIPOQ, RETN, LEP, INS
10polycystic ovary syndrome30.7INS, LEP
11type 2 diabetes mellitus30.6INS, ADIPOQ, RETN, SLC17A5, GPT, LEP
12diabetes mellitus30.6ADIPOR1, CYP2E1, GPT, INS, LEP, RETN
13siderosis30.5HFE, GPT
14cholangitis30.5SLC17A5, GPT
15pancreatitis30.5CYP2E1, INS, SLC17A5
16lipodystrophy30.5RETN, ADIPOQ, INS, LEP
17acute liver failure30.5GPT, SLC17A5
18atherosclerosis30.4INS, RETN, ADIPOQ, LEP
19hepatitis b30.4GPT, SLC17A5
20portal hypertension30.4SLC17A5, RETN, GPT
21autoimmune hepatitis30.4SLC17A5, GPT, KRT18
22morbid obesity30.4LEP, INS
23hypopituitarism30.4INS, LEP
24obstructive sleep apnea30.3ADIPOQ, LEP
25coronary artery disease30.3HFE, ADIPOR1, ADIPOQ, RETN, INS
26glucose intolerance30.3LEP, INS, ADIPOQ, GPT, RETN
27hypertension30.3RETN, LEP, INS
28viral hepatitis30.3KRT18, HFE, SLC17A5, GPT
29acanthosis nigricans30.3INS, LEP, ADIPOQ
30growth hormone deficiency30.3LEP, ADIPOQ, INS
31alcoholic liver cirrhosis30.3HFE, SLC17A5, GPT, CYP2E1
32breast cancer30.1ADIPOR1, CYP2E1, INS, KRT18, LEP
33liver cirrhosis30.0GPT, HFE, SLC17A5, KRT18, CYP2E1, ADIPOQ
34liver disease11.0
35hepatitis c virus10.6
36blindness10.4
37ischemia10.3
38vaginitis10.3
39familial mediterranean fever10.3
40hyperhomocysteinemia10.3
41irritable bowel syndrome10.3
42primary biliary cirrhosis10.3
43sclerosing cholangitis10.3
44artery disease10.3
45colorectal cancer10.3
46prostatitis10.3
47retinitis10.3
48serine deficiency10.3
49primary sclerosing cholangitis10.3
50autonomic dysfunction10.3

Graphical network of the top 20 diseases related to Nonalcoholic Steatohepatitis:



Diseases related to nonalcoholic steatohepatitis

Symptoms for Nonalcoholic Steatohepatitis

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Drugs & Therapeutics for Nonalcoholic Steatohepatitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Nonalcoholic Steatohepatitis

Drug clinical trials:

Search ClinicalTrials for Nonalcoholic Steatohepatitis

Search NIH Clinical Center for Nonalcoholic Steatohepatitis

Search CenterWatch for Nonalcoholic Steatohepatitis

Genetic Tests for Nonalcoholic Steatohepatitis

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Anatomical Context for Nonalcoholic Steatohepatitis

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34MalaCards
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MalaCards organs/tissues related to Nonalcoholic Steatohepatitis:

34
Liver, Ovary, Testes, Small intestine, Kidney, Bone, Breast, Myeloid, T cells, Endothelial, Thyroid

Animal Models for Nonalcoholic Steatohepatitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Nonalcoholic Steatohepatitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.1INS, LEP, ADIPOR1, ADIPOQ, RETN
2MP:00053847.8SLC17A5, HFE, ADIPOQ, ADIPOR1, LEP, INS
3MP:00053787.2INS, LEP, ADIPOR1, ADIPOQ, HFE, KRT18
4MP:00053867.0CYP2E1, INS, LEP, ADIPOR1, ADIPOQ, HFE
5MP:00107686.7CYP2E1, INS, LEP, ADIPOQ, HFE, KRT18
6MP:00053766.7CYP2E1, INS, LEP, ADIPOR1, ADIPOQ, RETN
7MP:00053706.6KRT18, CYP2E1, INS, LEP, ADIPOR1, ADIPOQ

Publications for Nonalcoholic Steatohepatitis

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53PubMed
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Articles related to Nonalcoholic Steatohepatitis:

(show top 50)    (show all 617)
idTitleAuthorsYear
1
Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes. (24375162)
2014
2
Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. (23832448)
2014
3
Modeling Human Nonalcoholic Steatohepatitis-Associated Changes in Drug Transporter Expression Using Experimental Rodent Models. (24384915)
2014
4
Author reply: comment to "atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-I+-lowering property". (22909420)
2013
5
Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis. (24066058)
2013
6
Immune therapy for nonalcoholic steatohepatitis: are we there yet? (23442833)
2013
7
Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. (23640861)
2013
8
Cytokeratin 18, alanine aminotransferase, platelets and triglycerides predict the presence of nonalcoholic steatohepatitis. (24324749)
2013
9
Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. (22915297)
2012
10
The effects of long-term melatonin treatment on plasma liver enzymes levels and plasma concentrations of lipids and melatonin in patients with nonalcoholic steatohepatitis: a pilot study. (22460459)
2012
11
Liver: new biomarker identified for nonalcoholic steatohepatitis. (22371214)
2012
12
Nonalcoholic steatohepatitis versus steatosis: adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism. (22684858)
2012
13
Excellent posttransplant survival for patients with nonalcoholic steatohepatitis in the United States. (21932374)
2012
14
Noninvasive clinical model for the diagnosis of nonalcoholic steatohepatitis in overweight and morbidly obese patients undergoing bariatric surgery. (23294957)
2012
15
Serologic predictors of nonalcoholic steatohepatitis in a population undergoing bariatric surgery. (21865094)
2012
16
Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-I+ production. (23066023)
2012
17
Mesenchymal stem cell therapy on murine model of nonalcoholic steatohepatitis. (22167651)
2012
18
Centrizonal arteries and microvessels in nonalcoholic steatohepatitis. (21836480)
2011
19
Adiponectin suppresses endoplasmic reticulum stress in nonalcoholic steatohepatitis. (22977616)
2011
20
Osteopontin: a missing link between hedgehog signaling and fibrosis in nonalcoholic steatohepatitis. (21274859)
2011
21
Pharmacological therapy of nonalcoholic steatohepatitis. (21338452)
2011
22
Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis. (20556839)
2010
23
Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice. (20566747)
2010
24
Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content. (20357081)
2010
25
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. (19914374)
2010
26
Serum cytokeratin-18 fragment level: a noninvasive biomarker for not only nonalcoholic steatohepatitis, but also alcoholic steatohepatitis. (20041411)
2010
27
PPARgamma is essential for protection against nonalcoholic steatohepatitis. (20376096)
2010
28
Effects of Teucrium polium on Insulin Resistance in Nonalcoholic Steatohepatitis. (20633523)
2010
29
Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgery. (19573756)
2009
30
Assessment of hepatic steatosis and hepatic tissue blood flow by xenon computed tomography in nonalcoholic steatohepatitis. (18761681)
2009
31
Wilson's disease masquerading as nonalcoholic steatohepatitis. (22666674)
2009
32
Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease. (19938128)
2009
33
Biomarkers for noninvasive biochemical diagnosis of nonalcoholic steatohepatitis: tools or decorations? (19750583)
2009
34
Treatment of nonalcoholic steatohepatitis with colestimide. (19473432)
2009
35
Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis. (19422479)
2009
36
Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis. (19424798)
2009
37
Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. (19637190)
2009
38
Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver. (19141695)
2009
39
A rabbit model of pediatric nonalcoholic steatohepatitis: the role of adiponectin. (19248189)
2009
40
Imaging of nonalcoholic steatohepatitis: advantages and pitfalls of ultrasonography and computed tomography. (19443967)
2009
41
Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats. (19004024)
2009
42
Nonalcoholic steatohepatitis: pathogenesis and treatment]. (18367854)
2008
43
Rosiglitazone for nonalcoholic steatohepatitis. (19013165)
2008
44
HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis. (17680648)
2007
45
Nonalcoholic steatohepatitis in obese children: the prevalence and possible mechanism]. (16470923)
2006
46
Elevated urine neopterin levels in nonalcoholic steatohepatitis. (15642284)
2005
47
Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. (14512888)
2003
48
Serum lipids, lipoproteins and apolipoproteins levels in patients with nonalcoholic steatohepatitis. (12869892)
2003
49
Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. (11438497)
2001
50
Nonalcoholic steatohepatitis. Clinicopathological comparison with alcoholic hepatitis in ambulatory and hospitalized patients. (8565753)
1996

Variations for Nonalcoholic Steatohepatitis

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Expression for genes affiliated with Nonalcoholic Steatohepatitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nonalcoholic Steatohepatitis

Search GEO for disease gene expression data for Nonalcoholic Steatohepatitis.

Pathways for genes affiliated with Nonalcoholic Steatohepatitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 13EMD Millipore, 31KEGG, 52PharmGKB, 55R&D Systems, 61Thomson Reuters, 54QIAGEN, 56Reactome
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Pathways related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5LEP, INS
29.5ADIPOQ, RETN
39.5RETN, ADIPOQ
4
Show member pathways
9.4ADIPOQ, INS
59.2INS, CYP2E1
68.8ADIPOQ, ADIPOR1, LEP
78.8LEP, ADIPOR1, ADIPOQ
88.5INS, LEP, ADIPOQ, RETN
9
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.5RETN, ADIPOQ, LEP, INS
10
Show member pathways
7.6ADIPOQ, ADIPOR1, LEP, INS, CYP2E1

Compounds for genes affiliated with Nonalcoholic Steatohepatitis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 3BitterDB, 62Tocris Bioscience
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Compounds related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1beta-hydroxybutyrate469.5SLC17A5, LEP, INS
2stavudine46 1210.2ADIPOQ, LEP, GPT
3sibutramine46 1210.2LEP, ADIPOQ, INS
4ezetimibe46 1210.2ADIPOQ, INS, GPT, SLC17A5
5glimepiride46 52 1211.2INS, ADIPOQ, RETN
6rosuvastatin46 52 30 1212.2INS, GPT, SLC17A5, ADIPOQ
7bezafibrate46 30 1211.1ADIPOQ, INS, GPT, SLC17A5
8acipimox46 3010.1ADIPOQ, INS, LEP
9urea46 25 1211.1GPT, RETN, KRT18, SLC17A5
10lamivudine46 52 1211.1GPT, LEP, SLC17A5, ADIPOQ
11atorvastatin46 52 30 25 1213.0GPT, ADIPOQ, RETN, SLC17A5
12olanzapine46 52 30 25 1212.9LEP, INS, ADIPOQ, SLC17A5
13telmisartan46 30 1210.9LEP, INS, ADIPOQ
14thiazolidinedione468.9ADIPOQ, INS, LEP, RETN
15sevoflurane52 46 1210.9SLC17A5, GPT, CYP2E1
168-isoprostane468.9INS, ADIPOQ, LEP, RETN
17dhea468.9INS, LEP, RETN, ADIPOQ
18acetaminophen46 3 52 25 1212.9SLC17A5, GPT, KRT18, CYP2E1
19troglitazone46 30 62 1211.7GPT, INS, LEP, ADIPOQ, SLC17A5
20ethanol46 52 25 1211.5HFE, CYP2E1, SLC17A5, KRT18, GPT
21p003468.5LEP, HFE, ADIPOQ, RETN, ADIPOR1
22norepinephrine46 25 1210.5ADIPOQ, LEP, RETN, INS, SLC17A5
23androstenedione46 259.4CYP2E1, INS, LEP, ADIPOQ
24aspartate468.4KRT18, RETN, HFE, GPT, SLC17A5, ADIPOQ
25cocaine46 129.4LEP, SLC17A5, ADIPOQ, GPT
26clozapine46 30 52 1211.4ADIPOQ, LEP, GPT, CYP2E1
27glycogen46 259.4ADIPOQ, GPT, INS, KRT18, RETN, SLC17A5
28fenofibrate46 52 1210.3GPT, SLC17A5, ADIPOQ, INS, RETN, LEP
29metformin46 52 1210.3INS, SLC17A5, GPT, LEP, ADIPOQ, RETN
30thyroxine46 259.3LEP, ADIPOQ, RETN, INS, GPT, SLC17A5
31c-peptide468.2INS, SLC17A5, ADIPOQ, LEP, RETN, ADIPOR1
32p002468.1ADIPOR1, LEP, GPT, RETN, KRT18, ADIPOQ
33uric acid46 259.0HFE, RETN, ADIPOQ, LEP, SLC17A5, INS
34alanine468.0HFE, KRT18, SLC17A5, RETN, ADIPOQ, INS
35vitamin a46 25 129.9GPT, CYP2E1, LEP, SLC17A5, ADIPOQ, RETN
36lactate467.9INS, GPT, CYP2E1, KRT18, SLC17A5, ADIPOQ
37fibrinogen467.9RETN, INS, GPT, LEP, ADIPOQ, KRT18
38ascorbic acid46 258.8KRT18, CYP2E1, LEP, SLC17A5, ADIPOQ, HFE
39pioglitazone30 46 52 1210.8LEP, ADIPOR1, ADIPOQ, SLC17A5, INS, GPT
40glutamate467.8KRT18, GPT, LEP, SLC17A5, RETN, ADIPOQ
41rosiglitazone30 46 52 25 1211.8RETN, GPT, INS, LEP, ADIPOR1, ADIPOQ
42estrogen467.8KRT18, INS, HFE, LEP, ADIPOQ, RETN
43fatty acid467.7RETN, SLC17A5, KRT18, ADIPOQ, ADIPOR1, LEP
44dexamethasone46 52 30 1210.5ADIPOQ, KRT18, RETN, CYP2E1, INS, LEP
45cholesterol46 30 25 1210.5SLC17A5, INS, GPT, ADIPOR1, LEP, ADIPOQ
46creatinine467.1KRT18, ADIPOQ, SLC17A5, RETN, LEP, INS
47glucose467.0HFE, GPT, LEP, INS, ADIPOR1, ADIPOQ
48nash466.8CYP2E1, KRT18, HFE, RETN, ADIPOQ, LEP
49testosterone46 62 25 129.6CYP2E1, SLC17A5, KRT18, RETN, HFE, ADIPOQ
50lipid466.2GPT, SLC17A5, KRT18, ADIPOQ, LEP, RETN

GO Terms for genes affiliated with Nonalcoholic Steatohepatitis

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17Gene Ontology
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Cellular components related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5RETN, ADIPOQ, LEP, INS

Biological processes related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of feeding behaviorGO:20002529.9RETN, INS
2leptin-mediated signaling pathwayGO:0332109.7ADIPOR1, LEP
3negative regulation of gluconeogenesisGO:0457219.6ADIPOQ, INS
4positive regulation of cellular protein metabolic processGO:0322709.6ADIPOQ, INS
5adiponectin-activated signaling pathwayGO:0332119.6ADIPOR1, ADIPOQ
6positive regulation of MAPK cascadeGO:0434109.5LEP, INS
7positive regulation of glucose importGO:0463269.4INS, ADIPOQ
8fatty acid oxidationGO:0193959.4ADIPOQ, ADIPOR1
9response to insulinGO:0328689.3RETN, LEP
10positive regulation of insulin receptor signaling pathwayGO:0466289.3ADIPOR1, LEP, INS
11circadian rhythmGO:0076239.2ADIPOQ, LEP
12glucose metabolic processGO:0060069.1INS, LEP, ADIPOQ

Molecular functions related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.5RETN, ADIPOQ, LEP, INS

Products for genes affiliated with Nonalcoholic Steatohepatitis

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  • Antibodies
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Sources for Nonalcoholic Steatohepatitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet