NASH
MCID: NNL002
MIFTS: 52

Nonalcoholic Steatohepatitis (NASH) malady

Rare diseases, Liver diseases categories
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Summaries for Nonalcoholic Steatohepatitis

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NIH Rare Diseases:42 Nonalcoholic steatohepatitis, or nash, is a common, often “silent” liver disease. it resembles alcoholic liver disease, but occurs in people who drink little or no alcohol. the major feature in nash is fat in the liver, along with inflammation and damage. most people with nash feel well and are not aware that they have a liver problem. nevertheless, nash can be severe and can lead to cirrhosis, in which the liver is permanently damaged and scarred and no longer able to work properly. nash most often occurs in people who are middle aged and overweight or obese. affected individuals may also have elevated levels of blood lipids (such as cholesterol and triglycerides) and many have diabetes or prediabetes. treatment is centered around working towards a healthy lifestyle, including weight reduction, dietary modification, increased activity and avoidance of alcohol and unnecessary medications. the underlying cause of nash remains unclear. last updated: 2/24/2012

MalaCards based summary: Nonalcoholic Steatohepatitis, also known as non-alcoholic fatty liver disease, is related to hepatitis and fatty liver disease. An important gene associated with Nonalcoholic Steatohepatitis is SLC17A5 (solute carrier family 17 (acidic sugar transporter), member 5), and among its related pathways are Signaling events mediated by PTP1B and Selected targets of C EBPbeta. The compounds beta-hydroxybutyrate and stavudine have been mentioned in the context of this disorder. Affiliated tissues include liver, ovary and testes, and related mouse phenotypes are adipose tissue and cellular.

Aliases & Classifications for Nonalcoholic Steatohepatitis

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Nonalcoholic Steatohepatitis, Aliases & Descriptions:

Name: Nonalcoholic Steatohepatitis 42 62
Non-Alcoholic Fatty Liver Disease 42 62
 
Non-Alcoholic Steatohepatitis 42
Nash 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Liver diseases


Related Diseases for Nonalcoholic Steatohepatitis

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Diseases related to Nonalcoholic Steatohepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.6CYP2E1, SLC17A5, GPT, HFE
2fatty liver disease31.4CYP2E1, ADIPOQ, SLC17A5
3alcoholic hepatitis31.1GPT, KRT18, SLC17A5
4hyperuricemia31.0INS, GPT
5siderosis31.0HFE, GPT
6cholangitis30.9SLC17A5, GPT
7acute liver failure30.9GPT, SLC17A5
8polycystic ovary syndrome30.9INS, LEP
9hepatitis c30.8CYP2E1, GPT, HFE, SLC17A5, KRT18
10portal hypertension30.7SLC17A5, RETN, GPT
11hepatitis b30.6GPT, SLC17A5
12autoimmune hepatitis30.6SLC17A5, GPT, KRT18
13morbid obesity30.6LEP, INS
14hypopituitarism30.6INS, LEP
15essential hypertension30.6ADIPOQ, RETN, LEP, INS
16obstructive sleep apnea30.6ADIPOQ, LEP
17pancreatitis30.5CYP2E1, INS, SLC17A5
18hypertension30.4RETN, LEP, INS
19viral hepatitis30.4KRT18, HFE, SLC17A5, GPT
20acanthosis nigricans30.3INS, LEP, ADIPOQ
21lipodystrophy30.3RETN, ADIPOQ, INS, LEP
22growth hormone deficiency30.3LEP, ADIPOQ, INS
23atherosclerosis30.3INS, RETN, ADIPOQ, LEP
24alcoholic liver cirrhosis30.2HFE, SLC17A5, GPT, CYP2E1
25type 2 diabetes mellitus30.0INS, ADIPOQ, RETN, SLC17A5, GPT, LEP
26glucose intolerance30.0LEP, INS, ADIPOQ, GPT, RETN
27obesity29.7CYP2E1, GPT, INS, LEP, ADIPOR1, ADIPOQ
28insulin resistance29.6CYP2E1, GPT, INS, LEP, ADIPOR1, ADIPOQ
29liver cancer29.6INS, CYP2E1, GPT, KRT18, SLC17A5, HFE
30breast cancer29.4ADIPOR1, CYP2E1, INS, KRT18, LEP
31diabetes mellitus29.4ADIPOR1, CYP2E1, GPT, INS, LEP, RETN
32liver cirrhosis29.2GPT, HFE, SLC17A5, KRT18, CYP2E1, ADIPOQ
33liver disease11.0
34hepatocellular carcinoma10.8
35hepatitis c virus10.6
36rabson-mendenhall syndrome10.5INS
37fascioliasis10.5SLC17A5
38blindness10.4
39pyridoxine deficiency10.4SLC17A5, GPT
40obstructive jaundice10.4SLC17A5, GPT
41choledocholithiasis10.4SLC17A5, GPT
42ischemia10.4
43vaginitis10.4
44hellp syndrome10.4SLC17A5, GPT
45scrub typhus10.4SLC17A5, GPT
46hepatic encephalopathy10.3SLC17A5, GPT
47bilirubin metabolic disorder10.3SLC17A5, GPT
48splenomegaly10.3SLC17A5, GPT
4921-hydroxylase deficiency10.3SLC17A5, GPT
50colorectal cancer10.3

Graphical network of the top 20 diseases related to Nonalcoholic Steatohepatitis:



Diseases related to nonalcoholic steatohepatitis

Symptoms for Nonalcoholic Steatohepatitis

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Drugs & Therapeutics for Nonalcoholic Steatohepatitis

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Drug clinical trials:

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Genetic Tests for Nonalcoholic Steatohepatitis

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Anatomical Context for Nonalcoholic Steatohepatitis

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MalaCards organs/tissues related to Nonalcoholic Steatohepatitis:

32
Liver, Ovary, Testes, Small intestine, Kidney, T cells, Bone, Thyroid, Breast, Myeloid, Endothelial

Animal Models for Nonalcoholic Steatohepatitis or affiliated genes

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MGI Mouse Phenotypes related to Nonalcoholic Steatohepatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.1INS, LEP, ADIPOR1, ADIPOQ, RETN
2MP:00053847.8SLC17A5, HFE, ADIPOQ, ADIPOR1, LEP, INS
3MP:00053787.2INS, LEP, ADIPOR1, ADIPOQ, HFE, KRT18
4MP:00053867.0CYP2E1, INS, LEP, ADIPOR1, ADIPOQ, HFE
5MP:00107686.7CYP2E1, INS, LEP, ADIPOQ, HFE, KRT18
6MP:00053766.7CYP2E1, INS, LEP, ADIPOR1, ADIPOQ, RETN
7MP:00053706.6KRT18, CYP2E1, INS, LEP, ADIPOR1, ADIPOQ

Publications for Nonalcoholic Steatohepatitis

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Articles related to Nonalcoholic Steatohepatitis:

(show top 50)    (show all 643)
idTitleAuthorsYear
1
High-fat diet decreases activity of the oxidative phosphorylation complexes and causes nonalcoholic steatohepatitis in mice. (25261569)
2014
2
Complement alternative pathway activation in human nonalcoholic steatohepatitis. (25299043)
2014
3
Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes. (24375162)
2014
4
Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. (23832448)
2014
5
Modeling Human Nonalcoholic Steatohepatitis-Associated Changes in Drug Transporter Expression Using Experimental Rodent Models. (24384915)
2014
6
Author reply: comment to "atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-I+-lowering property". (22909420)
2013
7
Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis. (24066058)
2013
8
Immune therapy for nonalcoholic steatohepatitis: are we there yet? (23442833)
2013
9
Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. (23640861)
2013
10
Cytokeratin 18, alanine aminotransferase, platelets and triglycerides predict the presence of nonalcoholic steatohepatitis. (24324749)
2013
11
Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. (22915297)
2012
12
The effects of long-term melatonin treatment on plasma liver enzymes levels and plasma concentrations of lipids and melatonin in patients with nonalcoholic steatohepatitis: a pilot study. (22460459)
2012
13
Liver: new biomarker identified for nonalcoholic steatohepatitis. (22371214)
2012
14
Nonalcoholic steatohepatitis versus steatosis: adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism. (22684858)
2012
15
Excellent posttransplant survival for patients with nonalcoholic steatohepatitis in the United States. (21932374)
2012
16
Noninvasive clinical model for the diagnosis of nonalcoholic steatohepatitis in overweight and morbidly obese patients undergoing bariatric surgery. (23294957)
2012
17
Serologic predictors of nonalcoholic steatohepatitis in a population undergoing bariatric surgery. (21865094)
2012
18
Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-I+ production. (23066023)
2012
19
Mesenchymal stem cell therapy on murine model of nonalcoholic steatohepatitis. (22167651)
2012
20
Centrizonal arteries and microvessels in nonalcoholic steatohepatitis. (21836480)
2011
21
Adiponectin suppresses endoplasmic reticulum stress in nonalcoholic steatohepatitis. (22977616)
2011
22
Osteopontin: a missing link between hedgehog signaling and fibrosis in nonalcoholic steatohepatitis. (21274859)
2011
23
Major histocompatibility complex class I-related chains A and B (MIC A/B): a novel role in nonalcoholic steatohepatitis. (19998387)
2010
24
Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis. (20556839)
2010
25
Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice. (20566747)
2010
26
Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content. (20357081)
2010
27
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. (19914374)
2010
28
Serum cytokeratin-18 fragment level: a noninvasive biomarker for not only nonalcoholic steatohepatitis, but also alcoholic steatohepatitis. (20041411)
2010
29
PPARgamma is essential for protection against nonalcoholic steatohepatitis. (20376096)
2010
30
Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgery. (19573756)
2009
31
Assessment of hepatic steatosis and hepatic tissue blood flow by xenon computed tomography in nonalcoholic steatohepatitis. (18761681)
2009
32
Wilson's disease masquerading as nonalcoholic steatohepatitis. (22666674)
2009
33
Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease. (19938128)
2009
34
Biomarkers for noninvasive biochemical diagnosis of nonalcoholic steatohepatitis: tools or decorations? (19750583)
2009
35
Treatment of nonalcoholic steatohepatitis with colestimide. (19473432)
2009
36
Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis. (19422479)
2009
37
Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis. (19424798)
2009
38
Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. (19637190)
2009
39
Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver. (19141695)
2009
40
A rabbit model of pediatric nonalcoholic steatohepatitis: the role of adiponectin. (19248189)
2009
41
Imaging of nonalcoholic steatohepatitis: advantages and pitfalls of ultrasonography and computed tomography. (19443967)
2009
42
Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats. (19004024)
2009
43
Nonalcoholic steatohepatitis: pathogenesis and treatment]. (18367854)
2008
44
Decreased phagocytic activity of Kupffer cells in a rat nonalcoholic steatohepatitis model. (18932283)
2008
45
HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis. (17680648)
2007
46
Nonalcoholic steatohepatitis in obese children: the prevalence and possible mechanism]. (16470923)
2006
47
Elevated urine neopterin levels in nonalcoholic steatohepatitis. (15642284)
2005
48
Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. (14512888)
2003
49
Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. (11438497)
2001
50
Nonalcoholic steatohepatitis. Clinicopathological comparison with alcoholic hepatitis in ambulatory and hospitalized patients. (8565753)
1996

Variations for Nonalcoholic Steatohepatitis

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Expression for genes affiliated with Nonalcoholic Steatohepatitis

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Expression patterns in normal tissues for genes affiliated with Nonalcoholic Steatohepatitis

Search GEO for disease gene expression data for Nonalcoholic Steatohepatitis.

Pathways for genes affiliated with Nonalcoholic Steatohepatitis

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Pathways related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5LEP, INS
29.5ADIPOQ, RETN
39.5RETN, ADIPOQ
4
Show member pathways
9.4ADIPOQ, INS
59.2INS, CYP2E1
68.8ADIPOQ, ADIPOR1, LEP
78.8LEP, ADIPOR1, ADIPOQ
88.5INS, LEP, ADIPOQ, RETN
9
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.5RETN, ADIPOQ, LEP, INS
10
Show member pathways
7.6ADIPOQ, ADIPOR1, LEP, INS, CYP2E1

Compounds for genes affiliated with Nonalcoholic Steatohepatitis

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Compounds related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1beta-hydroxybutyrate449.5SLC17A5, LEP, INS
2stavudine44 1110.2ADIPOQ, LEP, GPT
3sibutramine44 1110.2LEP, ADIPOQ, INS
4ezetimibe44 1110.2ADIPOQ, INS, GPT, SLC17A5
5glimepiride44 50 1111.2INS, ADIPOQ, RETN
6rosuvastatin44 50 28 1112.2INS, GPT, SLC17A5, ADIPOQ
7bezafibrate44 28 1111.1ADIPOQ, INS, GPT, SLC17A5
8acipimox44 2810.1ADIPOQ, INS, LEP
9urea44 24 1111.1GPT, RETN, KRT18, SLC17A5
10lamivudine44 50 1111.1GPT, LEP, SLC17A5, ADIPOQ
11atorvastatin44 50 28 24 1113.0GPT, ADIPOQ, RETN, SLC17A5
12olanzapine44 50 28 24 1112.9LEP, INS, ADIPOQ, SLC17A5
13telmisartan44 28 1110.9LEP, INS, ADIPOQ
14thiazolidinedione448.9ADIPOQ, INS, LEP, RETN
15sevoflurane50 44 1110.9SLC17A5, GPT, CYP2E1
168-isoprostane448.9INS, ADIPOQ, LEP, RETN
17dhea448.9INS, LEP, RETN, ADIPOQ
18acetaminophen44 2 50 24 1112.9SLC17A5, GPT, KRT18, CYP2E1
19troglitazone44 28 61 1111.7GPT, INS, LEP, ADIPOQ, SLC17A5
20ethanol44 50 24 1111.5HFE, CYP2E1, SLC17A5, KRT18, GPT
21p003448.5LEP, HFE, ADIPOQ, RETN, ADIPOR1
22norepinephrine44 24 1110.5ADIPOQ, LEP, RETN, INS, SLC17A5
23androstenedione44 249.4CYP2E1, INS, LEP, ADIPOQ
24aspartate448.4KRT18, RETN, HFE, GPT, SLC17A5, ADIPOQ
25cocaine44 119.4LEP, SLC17A5, ADIPOQ, GPT
26clozapine44 28 50 1111.4ADIPOQ, LEP, GPT, CYP2E1
27glycogen44 249.4ADIPOQ, GPT, INS, KRT18, RETN, SLC17A5
28fenofibrate44 50 1110.3GPT, SLC17A5, ADIPOQ, INS, RETN, LEP
29metformin44 50 1110.3INS, SLC17A5, GPT, LEP, ADIPOQ, RETN
30thyroxine44 249.3LEP, ADIPOQ, RETN, INS, GPT, SLC17A5
31c-peptide448.2INS, SLC17A5, ADIPOQ, LEP, RETN, ADIPOR1
32p002448.1ADIPOR1, LEP, GPT, RETN, KRT18, ADIPOQ
33uric acid44 249.0HFE, RETN, ADIPOQ, LEP, SLC17A5, INS
34alanine448.0HFE, KRT18, SLC17A5, RETN, ADIPOQ, INS
35vitamin a44 24 119.9GPT, CYP2E1, LEP, SLC17A5, ADIPOQ, RETN
36lactate447.9INS, GPT, CYP2E1, KRT18, SLC17A5, ADIPOQ
37fibrinogen447.9RETN, INS, GPT, LEP, ADIPOQ, KRT18
38ascorbic acid44 248.8KRT18, CYP2E1, LEP, SLC17A5, ADIPOQ, HFE
39pioglitazone28 44 50 1110.8LEP, ADIPOR1, ADIPOQ, SLC17A5, INS, GPT
40glutamate447.8KRT18, GPT, LEP, SLC17A5, RETN, ADIPOQ
41rosiglitazone28 44 50 24 1111.8RETN, GPT, INS, LEP, ADIPOR1, ADIPOQ
42estrogen447.8KRT18, INS, HFE, LEP, ADIPOQ, RETN
43fatty acid447.7RETN, SLC17A5, KRT18, ADIPOQ, ADIPOR1, LEP
44dexamethasone44 50 28 1110.5ADIPOQ, KRT18, RETN, CYP2E1, INS, LEP
45cholesterol44 28 24 1110.5SLC17A5, INS, GPT, ADIPOR1, LEP, ADIPOQ
46creatinine447.1KRT18, ADIPOQ, SLC17A5, RETN, LEP, INS
47glucose447.0HFE, GPT, LEP, INS, ADIPOR1, ADIPOQ
48nash446.8CYP2E1, KRT18, HFE, RETN, ADIPOQ, LEP
49testosterone44 61 24 119.6CYP2E1, SLC17A5, KRT18, RETN, HFE, ADIPOQ
50lipid446.2GPT, SLC17A5, KRT18, ADIPOQ, LEP, RETN

GO Terms for genes affiliated with Nonalcoholic Steatohepatitis

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Cellular components related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5RETN, ADIPOQ, LEP, INS

Biological processes related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of feeding behaviorGO:20002529.9RETN, INS
2leptin-mediated signaling pathwayGO:0332109.7ADIPOR1, LEP
3negative regulation of gluconeogenesisGO:0457219.6ADIPOQ, INS
4positive regulation of cellular protein metabolic processGO:0322709.6ADIPOQ, INS
5adiponectin-activated signaling pathwayGO:0332119.6ADIPOR1, ADIPOQ
6positive regulation of MAPK cascadeGO:0434109.5LEP, INS
7positive regulation of glucose importGO:0463269.4INS, ADIPOQ
8fatty acid oxidationGO:0193959.4ADIPOQ, ADIPOR1
9response to insulinGO:0328689.3RETN, LEP
10positive regulation of insulin receptor signaling pathwayGO:0466289.3ADIPOR1, LEP, INS
11circadian rhythmGO:0076239.2ADIPOQ, LEP
12glucose metabolic processGO:0060069.1INS, LEP, ADIPOQ

Molecular functions related to Nonalcoholic Steatohepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.5RETN, ADIPOQ, LEP, INS

Products for genes affiliated with Nonalcoholic Steatohepatitis

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Sources for Nonalcoholic Steatohepatitis

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3CDC
13ExPASy
14FMA
22GTR
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
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