MCID: NNR004
MIFTS: 58

Nonarteritic Anterior Ischemic Optic Neuropathy

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards integrated aliases for Nonarteritic Anterior Ischemic Optic Neuropathy:

Name: Nonarteritic Anterior Ischemic Optic Neuropathy 53 12 28 69
Anterior Ischemic Optic Neuropathy 12 49 71 14 69
Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 53 28 13
Non-Arteritic Anterior Ischemic Optic Neuropathy 12 71 14
Naion 53 71 51
Optic Neuropathy, Ischemic 41 69
Ischemic Optic Neuropathy 12 49
Aion 49 71
Optic Neuropathy, Anterior Ischemic, Susceptibility to 53
Optic Neuropathy, Anterior Ischemic 53
Naion, Susceptibility to 53

Characteristics:

OMIM:

53
Inheritance:
autosomal recessive


HPO:

31
nonarteritic anterior ischemic optic neuropathy:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 53 258660
Disease Ontology 12 DOID:0050864 DOID:12010
ICD10 32 H47.01
ICD9CM 34 377.41
MeSH 41 D018917
SNOMED-CT 64 14357004
MedGen 39 C1847711
SNOMED-CT via HPO 65 258211005

Summaries for Nonarteritic Anterior Ischemic Optic Neuropathy

NIH Rare Diseases : 49 Anterior ischemic optic neuropathy (AION) is an eye disease characterized by infarction of the optic disk leading to vision loss. It can be nonarteritic (nonarteritic anterior ischemic optic neuropathy or NAION) or arteritic, the latter being associated with giant cell arteritis (GCA; often termed temporal arteritis).Vision loss with both varieties is typically rapid (over minutes, hours, or days) and painless. Symptoms such as a general feeling of being unwell (malaise), muscle aches and pains, headaches over the temple, pain when combing hair, pain in the jaw after chewing, and tenderness over the temporal artery (one of the major arteries of the head) may be present with giant cell arteritis. At exam, visual acuity is reduced and the optic disc is swollen. In both subtypes, visual field examination is often reduced in the inferior and central visual fields.The visual loss is usually permanent, with some recovery possibly occurring within the first weeks or months. The arteritic variety is treated with corticosteroids. Treatment of the nonarteritic variety with aspirin or corticosteroids has not been helpful.  Last updated: 10/21/2016

MalaCards based summary : Nonarteritic Anterior Ischemic Optic Neuropathy, also known as anterior ischemic optic neuropathy, is related to arteritic anterior ischemic optic neuropathy and sleep apnea. An important gene associated with Nonarteritic Anterior Ischemic Optic Neuropathy is GP1BA (Glycoprotein Ib Platelet Alpha Subunit), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Development Angiotensin activation of ERK. The drugs Carbidopa and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and kidney, and related phenotypes are homeostasis/metabolism and cardiovascular system

UniProtKB/Swiss-Prot : 71 Non-arteritic anterior ischemic optic neuropathy: An ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage.

Wikipedia : 72 Anterior ischemic optic neuropathy (AION) is a medical condition involving loss of vision caused by... more...

Description from OMIM: 258660

Related Diseases for Nonarteritic Anterior Ischemic Optic Neuropathy

Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 arteritic anterior ischemic optic neuropathy 32.0 ACE F2 F5 GP1BA MTHFR NOS3
2 sleep apnea 30.5 ACE EDN1 NOS3
3 antiphospholipid syndrome 29.8 F2 F5 MTHFR SERPINC1
4 thrombophilia 29.8 F2 F5 MTHFR SERPINC1
5 central retinal vein occlusion 29.6 F2 F5 MTHFR SERPINC1
6 retinal vein occlusion 29.6 F2 F5 MTHFR SERPINC1
7 retinal artery occlusion 29.5 ACE F2 F5 MTHFR SERPINC1
8 pulmonary hypertension 29.1 ACE EDN1 NOS3 PDE5A SERPINC1
9 ischemic optic neuropathy 28.1 ACE AGTR1 EDN1 F2 F5 GP1BA
10 neuropathy 11.2
11 retinitis 10.6
12 inferior vena cava interruption 10.4 F5 MTHFR
13 amaurosis fugax 10.4 F5 MTHFR
14 cerebral atherosclerosis 10.4 ACE MTHFR
15 pregnancy loss, recurrent 1 10.4 F5 MTHFR
16 catastrophic antiphospholipid syndrome 10.4 F5 MTHFR
17 choroiditis 10.4
18 optic neuritis 10.4
19 neuritis 10.4
20 renal artery obstruction 10.4 ACE SERPINC1
21 hemifacial spasm 10.3 MTHFR NOS3
22 coronary restenosis 10.3 ACE SERPINC1
23 sticky platelet syndrome 10.3 F5 SERPINC1
24 angina pectoris 10.3 ACE SERPINC1
25 apnea, obstructive sleep 10.3
26 diabetes mellitus 10.3
27 coronary thrombosis 10.3 GP1BA SERPINC1
28 pediatric osteosarcoma 10.3 EDN1 MTHFR
29 meningococcemia 10.2 F5 SERPINC1
30 factor xii deficiency 10.2 F5 SERPINC1
31 mesenteric vascular occlusion 10.2 F2 MTHFR
32 hepatoportal sclerosis 10.2 ACE F2
33 pure autonomic failure 10.2 ACE PDE5A
34 ischemic neuropathy 10.2 F2 MTHFR
35 intermediate coronary syndrome 10.2 ACE SERPINC1
36 paracetamol poisoning 10.2 F2 F5
37 aging 10.2
38 cataract 10.2
39 open-angle glaucoma 10.2
40 central retinal artery occlusion 10.2
41 refractive error 10.2
42 posner-schlossman syndrome 10.2
43 endotheliitis 10.2
44 legg-calve-perthes disease 10.2 F5 SERPINC1
45 idiopathic edema 10.2 ACE EDN1
46 cerebral sinovenous thrombosis 10.2 F2 F5
47 carotid artery occlusion 10.2 F5 NOS3
48 hemoglobin e disease 10.2 F2 F5
49 prinzmetal's variant angina 10.2 EDN1 NOS3
50 schizencephaly 10.2 F5 MTHFR

Comorbidity relations with Nonarteritic Anterior Ischemic Optic Neuropathy via Phenotypic Disease Network (PDN):


Hypertension, Essential Temporal Arteritis

Graphical network of the top 20 diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy:



Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy

Symptoms & Phenotypes for Nonarteritic Anterior Ischemic Optic Neuropathy

Symptoms via clinical synopsis from OMIM:

53
Eyes:
nonarteritic anterior ischemic optic neuropathy
papillophlebitis


Clinical features from OMIM:

258660

Human phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

31
# Description HPO Frequency HPO Source Accession
1 nonarteritic anterior ischemic optic neuropathy 31 HP:0007634

MGI Mouse Phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 F5 GP1BA MTHFR NOS3 SERPINC1 ACE
2 cardiovascular system MP:0005385 9.87 ACE AGTR1 EDN1 F2 F5 NOS3
3 mortality/aging MP:0010768 9.76 ACE AGTR1 EDN1 F2 F5 MTHFR
4 nervous system MP:0003631 9.5 MTHFR NOS3 SERPINC1 AGTR1 EDN1 F2
5 renal/urinary system MP:0005367 9.02 ACE AGTR1 EDN1 NOS3 SERPINC1

Drugs & Therapeutics for Nonarteritic Anterior Ischemic Optic Neuropathy

Drugs for Nonarteritic Anterior Ischemic Optic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carbidopa Approved Phase 4 28860-95-9 38101 34359
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Levodopa Approved Phase 4 59-92-7 6047
4
4-Aminopyridine Approved Phase 4 504-24-5 1727
5
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
6
Ephedrine Approved Phase 4 299-42-3 9294
7
Pseudoephedrine Approved Phase 4 90-82-4 7028
8
Choline Approved, Nutraceutical Phase 4,Not Applicable 62-49-7 305
9 Autonomic Agents Phase 4,Phase 3,Phase 2
10 Gastrointestinal Agents Phase 4,Phase 3
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Cytidine Diphosphate Choline Phase 4,Not Applicable
13 Nootropic Agents Phase 4,Not Applicable
14 Adjuvants, Immunologic Phase 4
15 Antiparkinson Agents Phase 4
16 Aromatic Amino Acid Decarboxylase Inhibitors Phase 4
17 Carbidopa, levodopa drug combination Phase 4
18 Dopamine Agents Phase 4
19 Dopamine agonists Phase 4
20 Neurotransmitter Agents Phase 4,Phase 1
21 Potassium Channel Blockers Phase 4
22 Phosphodiesterase 5 Inhibitors Phase 4
23 Phosphodiesterase Inhibitors Phase 4,Phase 2
24 Sildenafil Citrate Phase 4 171599-83-0
25 Vardenafil Dihydrochloride Phase 4
26 Adrenergic Agents Phase 4,Phase 1
27 Adrenergic Agonists Phase 4
28 Adrenergic alpha-2 Receptor Agonists Phase 4
29 Adrenergic alpha-Agonists Phase 4
30 Antihypertensive Agents Phase 4,Phase 3,Phase 1
31 Brimonidine Tartrate Phase 4 70359-46-5
32 Carboxymethylcellulose Sodium Phase 4
33 Cathartics Phase 4
34 Laxatives Phase 4
35 Nasal Decongestants Phase 4
36 Ophthalmic Solutions Phase 4
37 Pharmaceutical Solutions Phase 4,Not Applicable
38 Respiratory System Agents Phase 4
39 Tetrahydrozoline Phase 4
40 Vasoconstrictor Agents Phase 4
41
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
42
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
43
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
44
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
45 Antiemetics Phase 3
46 Anti-Inflammatory Agents Phase 3,Phase 1,Phase 2,Not Applicable
47 Antineoplastic Agents, Hormonal Phase 3
48 glucocorticoids Phase 3,Phase 1,Phase 2
49 Hormone Antagonists Phase 3,Phase 1,Phase 2
50 Hormones Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show all 46)

# Name Status NCT ID Phase Drugs
1 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
2 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
3 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
4 Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4 Cytidine-5’-diphosphocholine (Citicoline)
5 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT00867815 Phase 4 Diagnostic procedures
6 Preoperative Brimonidine on IOP of Patients Undergoing RALP Recruiting NCT02818816 Phase 4 brimonidine tartrate 0.2%
7 Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
8 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION Unknown status NCT02329288 Phase 3 Triamcinolone Acetonide;placebo
9 Ischemic Optic Neuropathy Decompression Trial (IONDT) Completed NCT00000127 Phase 3
10 Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - single low dose;QPI-1007 Injection - single high dose;QPI-1007 Injection - multiple low dose;QPI-1007 Injection - multiple high dose
11 ENDOTHELION Study Group: Effect of Bosentan in NAION Patients Recruiting NCT02377271 Phase 3 bosentan;placebo
12 Erythropoietin in Methanol Associated Optic Neuropathy: A Phase-2 Clinical Trial (EPO-MAON Study) Recruiting NCT02376881 Phase 3 Erythropoietin
13 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo Unknown status NCT01330524 Phase 1, Phase 2 Avastin and Triamcinolone
14 Intravitreal Bevacizumab for Non-Arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
15 Neurotomy of Optic Nerve in Non-Arthritic Anterior Ischemic Optic Neuropathy Completed NCT00372021 Phase 1, Phase 2
16 Safety and Efficacy Study of RPh201 Treatment of Ischemic Optic Neuropathy (ION). Completed NCT02045212 Phase 2 RPh201;Placebo
17 Effects of Moxaverine and Placebo on Ocular Blood Flow Completed NCT00709423 Phase 2 Moxaverine;Moxaverin 150mg;NaCl
18 Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non Arteritic Anterior Ischemic Optic Neuropathy Not yet recruiting NCT03173638 Phase 2
19 Intraocular Pressure During Prone Spinal Surgery Terminated NCT00176722 Phase 2
20 A Phase I Clinical Trial of DARC Unknown status NCT02394613 Phase 1 ANX776
21 Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients Completed NCT01064505 Phase 1 QPI-1007 at various doses
22 Ranibizumab Therapy for Non-arteritic Ischemic Optic Neuropathy Completed NCT00561834 Phase 1 ranibizumab
23 NT-501 CNTF Implant for Ischemic Optic Neuropathy: Safety, Neuroprotection and Neuroenhancement Completed NCT01411657 Phase 1 NT-501 CNTF Implant
24 Treatment Study for Ischemic Optic Neuropathy With Opthalmic Timolol Maleate 0.5% Withdrawn NCT01607671 Phase 1 Timolol maleate
25 Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup) Unknown status NCT00000126 Not Applicable
26 Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) Unknown status NCT00874913 Not Applicable
27 A Study to Determine if There is a Possible Association Between Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) and Phosphodiesterase Type 5 (PDE5) Inhibitors Completed NCT01131104 PDE5 Inhibitors
28 Vision Restoration Therapy (VRT) to Treat Non-Arteritic Anterior Ischemic Optic Neuropathy Completed NCT00140491
29 Epidemiology Study of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01260324
30 Electric Stimulation of the Eye to Improve Vision After Trauma Completed NCT02019927
31 Assessment of Visual Field-related Endpoints in Patients With Non-arteritic Ischemic Optic Neuropathy Completed NCT01614158
32 Safety and Efficacy of Using SightSaver Visual Evoked Potential (VEP) for VEP Monitoring in Prone Spine Surgery Completed NCT02643615 Not Applicable Propofol;Desflurane
33 Intraocular Pressure During Abdominal Aortic Aneurysm (AAA) Repair Completed NCT00450294 Not Applicable
34 Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours Completed NCT00875043
35 Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry Completed NCT01219569 propofol;Sevoflurane
36 Transcorneal Electrical Stimulation Therapy for Retinal Disease Completed NCT00804102 Not Applicable
37 Continuous Intraocular Pressure Patterns in Spine Surgery Completed NCT03299400 Not Applicable
38 Validation of the GATE Software Completed NCT01265628
39 Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy Recruiting NCT03401892
40 Effect of EECP on Anterior Ischemic Optic Neuropathy Recruiting NCT01768260 Not Applicable Aspirin
41 Biomechanics of Optic Neuropathy Recruiting NCT02982499
42 New Non-invasive Modalities for Assessing Retinal Structure and Function Recruiting NCT03475173 Not Applicable
43 Stem Cell Ophthalmology Treatment Study II Recruiting NCT03011541 Not Applicable
44 Influence of Oral Treatment With Citicoline for the Prevention of Radiation Optic Neuropathy in Patients Treated for Uveal Melanomas With Proton Beam Therapy Active, not recruiting NCT01338389 Not Applicable
45 Stem Cell Ophthalmology Treatment Study Enrolling by invitation NCT01920867 Not Applicable
46 Swept Source Enhanced Depth Imaging Optical Coherence Tomography Not yet recruiting NCT02443129 Not Applicable

Search NIH Clinical Center for Nonarteritic Anterior Ischemic Optic Neuropathy

Cochrane evidence based reviews: optic neuropathy, ischemic

Genetic Tests for Nonarteritic Anterior Ischemic Optic Neuropathy

Genetic tests related to Nonarteritic Anterior Ischemic Optic Neuropathy:

# Genetic test Affiliating Genes
1 Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 28 GP1BA
2 Nonarteritic Anterior Ischemic Optic Neuropathy 28

Anatomical Context for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards organs/tissues related to Nonarteritic Anterior Ischemic Optic Neuropathy:

38
Eye, Endothelial, Kidney, Liver, Neutrophil, B Cells, Retina

Publications for Nonarteritic Anterior Ischemic Optic Neuropathy

Articles related to Nonarteritic Anterior Ischemic Optic Neuropathy:

(show top 50) (show all 477)
# Title Authors Year
1
Anterior Ischemic Optic Neuropathy Due to Calciphylaxis. ( 29016409 )
2018
2
Hyperhomocysteinemia in bilateral anterior ischemic optic neuropathy after conventional coronary artery bypass graft: a case report. ( 29338755 )
2018
3
Risk of Ischemic Kidney Injury in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Population-based Study. ( 29330063 )
2018
4
Optical Coherence Tomography Angiography of the Peripapillary Retina in Normal-Tension Glaucoma and Chronic Nonarteritic Anterior Ischemic Optic Neuropathy. ( 29451992 )
2018
5
Comparison of the Retinal Microvascular Density Between Open Angle Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28687846 )
2017
6
Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28316838 )
2017
7
OCT angiography of acute non-arteritic anterior ischemic optic neuropathy. ( 28117076 )
2017
8
Oligodendrocyte death, neuroinflammation, and the effects of minocycline in a rodent model of nonarteritic anterior ischemic optic neuropathy (rNAION). ( 29386871 )
2017
9
Role of Nocturnal Arterial Hypotension in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28742640 )
2017
10
Neutrophil to Lymphocyte Ratio in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28367045 )
2017
11
High-dose intravenous pulse steroid therapy for optic disc swelling and subretinal fluid in non-arteritic anterior ischemic optic neuropathy. ( 28303068 )
2017
12
Nonarteritic Anterior Ischemic Optic Neuropathy and Intraocular Surgery. ( 28108001 )
2017
13
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886887 )
2017
14
Giant cell arteritis with arteritic anterior ischemic optic neuropathy. ( 28523333 )
2017
15
Nonarteritic anterior ischemic optic neuropathy: cause, effect, and management. ( 29033621 )
2017
16
Does Nocturnal Hypotension Play a Causal Role in Nonarteritic Anterior Ischemic Optic Neuropathy?: Response. ( 28742641 )
2017
17
Optical coherence tomography angiography of optic disc perfusion in non-arteritic anterior ischemic optic neuropathy. ( 28944200 )
2017
18
Optical Coherence Tomography Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28301863 )
2017
19
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy: Response. ( 28759500 )
2017
20
Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886893 )
2017
21
The Effect of Combined Systemic Erythropoietin and Steroid on Non-arteritic Anterior Ischemic Optic Neuropathy: A Prospective Study. ( 28632028 )
2017
22
Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations. ( 28846776 )
2017
23
A case of non-arteritic anterior ischemic optic neuropathy after completion of Harvoni therapy. ( 29260058 )
2017
24
Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28302535 )
2017
25
Relative Frequencies of Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy in an Arab Population. ( 28099197 )
2017
26
Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28438311 )
2017
27
Bilateral Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant Cell Arteritis in Korea. ( 28994270 )
2017
28
Sequential development of non-arteritic anterior ischemic optic neuropathy in a patient on hemodialysis. ( 28944153 )
2017
29
Dalfampridine Treatment in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28538037 )
2017
30
Use of Intravitreal Dexamethasone in a Case of Anterior Ischemic Optic Neuropathy. ( 28924446 )
2017
31
Postural effects on intraocular pressure and ocular perfusion pressure in patients with non-arteritic anterior ischemic optic neuropathy. ( 28427356 )
2017
32
Structure-Function Analysis of Nonarteritic Anterior Ischemic Optic Neuropathy and Age-Related Differences in Outcome. ( 28538035 )
2017
33
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28759499 )
2017
34
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort Study. ( 28093100 )
2017
35
Perioperative nonarteritic anterior ischemic optic neuropathy in Jehovah's Witnesses. ( 28457303 )
2017
36
Microvasculature dropout detected by the optical coherence tomography angiography in nonarteritic anterior ischemic optic neuropathy. ( 28986994 )
2017
37
Automated Evaluation of Choroidal Thickness and Minimum Rim Width Thickness in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28885450 )
2017
38
Assessment of nonarteritic anterior ischemic optic neuropathy with intravoxel incoherent motion diffusion-weighted imaging using readout-segmented echo-planar imaging, parallel imaging, and 2D navigator-based reacquisition. ( 28513892 )
2017
39
Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy. ( 28771491 )
2017
40
Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. ( 28861697 )
2017
41
Prospective Case-crossover Study Investigating the Possible Association Between Nonarteritic Anterior Ischemic Optic Neuropathy and Phosphodiesterase Type 5 Inhibitor Exposure. ( 28336289 )
2017
42
Visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. ( 28836961 )
2017
43
Takayasu arteritis presenting as isolated anterior ischemic optic neuropathy. ( 28389774 )
2017
44
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective CohortA Study. ( 28063480 )
2017
45
A Nonarteritic Anterior Ischemic Optic Neuropathy Clinical Trial: An Industry and NORDIC Collaboration. ( 27389625 )
2016
46
Efficacy of Intravitreal Injections of Triamcinolone Acetonide in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27082303 )
2016
47
Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27128315 )
2016
48
Can Corneal Biomechanical Properties Give Clues About Elasticity of Optic Nerve Scleral Component in Nonarteritic Anterior Ischemic Optic Neuropathy? ( 27389626 )
2016
49
Comparison of Visual Outcomes of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients with and without Diabetes Mellitus. ( 28017420 )
2016
50
Clinical and color Doppler imaging features of one patient with occult giant cell arteritis presenting arteritic anterior ischemic optic neuropathy. ( 27516038 )
2016

Variations for Nonarteritic Anterior Ischemic Optic Neuropathy

ClinVar genetic disease variations for Nonarteritic Anterior Ischemic Optic Neuropathy:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GP1BA GP1BA, 92-BP DUP, SER399-THR411 DUP, VARIABLE REPEATS duplication risk factor

Expression for Nonarteritic Anterior Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Nonarteritic Anterior Ischemic Optic Neuropathy.

Pathways for Nonarteritic Anterior Ischemic Optic Neuropathy

Pathways related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 F2 F5 GP1BA NOS3 PDE5A SERPINC1
2
Show member pathways
12.47 AGTR1 EDN1 F2 NOS3
3 11.69 F2 F5 SERPINC1
4 11.43 AGTR1 EDN1 NOS3
5
Show member pathways
11.23 ACE AGTR1 NOS3
6
Show member pathways
11.13 F2 F5 GP1BA SERPINC1
7
Show member pathways
11.08 NOS3 PDE5A
8 10.96 EDN1 NOS3
9 10.44 NOS3 PDE5A

GO Terms for Nonarteritic Anterior Ischemic Optic Neuropathy

Biological processes related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.74 F2 F5 SERPINC1
2 response to amino acid GO:0043200 9.58 EDN1 MTHFR
3 regulation of blood pressure GO:0008217 9.58 ACE EDN1 NOS3
4 blood vessel remodeling GO:0001974 9.56 ACE NOS3
5 blood coagulation GO:0007596 9.56 F2 F5 GP1BA SERPINC1
6 positive regulation of reactive oxygen species metabolic process GO:2000379 9.55 AGTR1 F2
7 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.54 AGTR1 EDN1
8 positive regulation of cardiac muscle hypertrophy GO:0010613 9.52 EDN1 PDE5A
9 fibrinolysis GO:0042730 9.51 F2 GP1BA
10 blood coagulation, intrinsic pathway GO:0007597 9.49 F2 GP1BA
11 regulation of blood vessel size GO:0050880 9.48 EDN1 NOS3
12 regulation of blood vessel diameter GO:0097746 9.46 ACE AGTR1
13 negative regulation of platelet activation GO:0010544 9.43 F2 NOS3
14 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.37 EDN1 NOS3
15 regulation of vasoconstriction GO:0019229 9.33 ACE AGTR1 EDN1
16 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.32 ACE AGTR1
17 regulation of blood coagulation GO:0030193 9.13 F2 GP1BA SERPINC1
18 hemostasis GO:0007599 8.92 F2 F5 GP1BA SERPINC1

Molecular functions related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 8.96 MTHFR NOS3
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Nonarteritic Anterior Ischemic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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