NAION
MCID: NNR004
MIFTS: 53

Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Nonarteritic Anterior Ischemic Optic Neuropathy

Aliases & Descriptions for Nonarteritic Anterior Ischemic Optic Neuropathy:

Name: Nonarteritic Anterior Ischemic Optic Neuropathy 54 12 29 29 69
Anterior Ischemic Optic Neuropathy 12 50 66 14 69
Non-Arteritic Anterior Ischemic Optic Neuropathy 12 66 14
Optic Neuropathy, Ischemic 42 69
Ischemic Optic Neuropathy 12 50
Naion 66 52
Aion 50 66
Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 13

Characteristics:

HPO:

32
nonarteritic anterior ischemic optic neuropathy:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 54 258660
Disease Ontology 12 DOID:0050864 DOID:12010
ICD10 33 H47.01
ICD9CM 35 377.41
MeSH 42 D018917
SNOMED-CT 64 14357004
MedGen 40 C1847711
UMLS 69 C0155305

Summaries for Nonarteritic Anterior Ischemic Optic Neuropathy

NIH Rare Diseases : 50 anterior ischemic optic neuropathy (aion) is an eye disease characterized by infarction of the optic disk leading to vision loss. it can be nonarteritic (nonarteritic anterior ischemic optic neuropathy or naion) or arteritic, the latter being associated with giant cell arteritis (gca; often termed temporal arteritis).vision loss with both varieties is typically rapid (over minutes, hours, or days) and painless. symptoms such as a general feeling of being unwell (malaise), muscle aches and pains, headaches over the temple, pain when combing hair, pain in the jaw after chewing, and tenderness over the temporal artery (one of the major arteries of the head) may be present with giant cell arteritis. at exam, visual acuity is reduced and the optic disc is swollen. in both subtypes, visual field examination is often reduced in the inferior and central visual fields.the visual loss is usually permanent, with some recovery possibly occurring within the first weeks or months. the arteritic variety is treated with corticosteroids. treatment of the nonarteritic variety with aspirin or corticosteroids has not been helpful.  last updated: 10/21/2016

MalaCards based summary : Nonarteritic Anterior Ischemic Optic Neuropathy, also known as anterior ischemic optic neuropathy, is related to ischemic optic neuropathy and central retinal artery occlusion. An important gene associated with Nonarteritic Anterior Ischemic Optic Neuropathy is GP1BA (Glycoprotein Ib Platelet Alpha Subunit), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Development Angiotensin activation of ERK. The drugs Dorzolamide and Timolol have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and neutrophil, and related phenotypes are cardiovascular system and homeostasis/metabolism

UniProtKB/Swiss-Prot : 66 Non-arteritic anterior ischemic optic neuropathy: An ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage.

Wikipedia : 71 Anterior ischemic optic neuropathy (AION) is a medical condition involving loss of vision caused by... more...

Description from OMIM: 258660

Related Diseases for Nonarteritic Anterior Ischemic Optic Neuropathy

Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
id Related Disease Score Top Affiliating Genes
1 ischemic optic neuropathy 31.7 ACE F2 SERPINC1
2 central retinal artery occlusion 30.3 F2 MTHFR SERPINC1
3 arteritic anterior ischemic optic neuropathy 12.6
4 neuropathy 11.1
5 retinitis 10.5
6 sleep apnea 10.3
7 optic neuritis 10.3
8 neuritis 10.3
9 pars planitis 10.3 ACE MTHFR
10 carbohydrate metabolic disorder 10.2 ACE SERPINC1
11 hypertrichosis 10.2 MTHFR SERPINC1
12 obstructive sleep apnea 10.2
13 choroiditis 10.2
14 myosclerosis, congenital 10.2 MTHFR SERPINC1
15 scn8a-related epilepsy with encephalopathy 10.2 F2 MTHFR
16 intracranial cysts 10.2 MTHFR NOS3
17 porphyria 10.2 F2 MTHFR
18 melorheostosis 10.2 ACE SERPINC1
19 lubinsky syndrome 10.2 F2 MTHFR
20 supraumbilical midabdominal raphe and facial cavernous hemangiomas 10.2 F2 MTHFR
21 familial progressive hyperpigmentation 10.2 ACE F2
22 secretory diarrhea myopathy and deafness 10.2 ACE SERPINC1
23 photosensitive epilepsy 10.2 F2 MTHFR
24 monocular exotropia 10.2 GP1BA SERPINC1
25 miller-dieker lissencephaly syndrome 10.2 F2 SERPINC1
26 influenza 10.2 F2 SERPINC1
27 freiberg's disease 10.2 F2 SERPINC1
28 pancreatic ductal carcinoma 10.2 F2 SERPINC1
29 chorioretinal scar 10.2 F2 SERPINC1
30 mixed hepatoblastoma 10.1 F2 SERPINC1
31 peanut allergy 10.1 F2 SERPINC1
32 may-hegglin anomaly 10.1 F2 SERPINC1
33 dmd-related dilated cardiomyopathy 10.1 F2 SERPINC1
34 midline cystocele 10.1 F2 SERPINC1
35 schwannoma of jugular foramen 10.1 F2 SERPINC1
36 houlston ironton temple syndrome 10.1 F2 MTHFR
37 rectal prolapse 10.1 NOS3 PDE5A
38 neuroaxonal dystrophy 10.1 F2 SERPINC1
39 antiphospholipid syndrome 10.1
40 retinal artery occlusion 10.1
41 refractive error 10.1
42 posner-schlossman syndrome 10.1
43 endotheliitis 10.1
44 cataract 10.1
45 thrombophilia 10.1
46 cerebellar astrocytoma 10.1 F2 SERPINC1
47 periosteal chondrosarcoma 10.1 F2 SERPINC1
48 angelucci's syndrome 10.1 F2 SERPINC1
49 proliferating trichilemmal cyst 10.1 EDN1 NOS3
50 ovarian papillary cystadenoma 10.1 F2 SERPINC1

Comorbidity relations with Nonarteritic Anterior Ischemic Optic Neuropathy via Phenotypic Disease Network (PDN):


Hypertension, Essential Temporal Arteritis

Graphical network of the top 20 diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy:



Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy

Symptoms & Phenotypes for Nonarteritic Anterior Ischemic Optic Neuropathy

Symptoms by clinical synopsis from OMIM:

258660

Clinical features from OMIM:

258660

Human phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

32
id Description HPO Frequency HPO Source Accession
1 nonarteritic anterior ischemic optic neuropathy 32 HP:0007634

MGI Mouse Phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 ACE AGTR1 EDN1 F2 NOS3 SERPINC1
2 homeostasis/metabolism MP:0005376 9.56 ACE AGTR1 EDN1 F2 GP1BA MTHFR
3 renal/urinary system MP:0005367 9.02 ACE AGTR1 EDN1 NOS3 SERPINC1

Drugs & Therapeutics for Nonarteritic Anterior Ischemic Optic Neuropathy

Drugs for Nonarteritic Anterior Ischemic Optic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 102)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dorzolamide Approved Phase 4 120279-96-1 3154 5284549
2
Timolol Approved Phase 4,Phase 1 26839-75-8 33624 5478
3
Carbidopa Approved Phase 4 28860-95-9 34359 38101
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Levodopa Approved Phase 4 59-92-7 6047
6
4-Aminopyridine Approved Phase 4 504-24-5 1727
7
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
8
Ephedrine Approved Phase 4 299-42-3 9294
9
Pseudoephedrine Approved Phase 4 90-82-4 7028
10
Choline Approved, Nutraceutical Phase 4 62-49-7 305
11 Adrenergic Agents Phase 4,Phase 1
12 Adrenergic Antagonists Phase 4,Phase 1
13 Adrenergic beta-Antagonists Phase 4,Phase 1
14 Anti-Arrhythmia Agents Phase 4,Phase 1
15 Antihypertensive Agents Phase 4,Phase 3,Phase 1
16 Carbonic Anhydrase Inhibitors Phase 4
17 Neurotransmitter Agents Phase 4,Phase 2,Phase 1
18 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Adjuvants, Immunologic Phase 4
22 Antiparkinson Agents Phase 4
23 Aromatic Amino Acid Decarboxylase Inhibitors Phase 4
24 Carbidopa, levodopa drug combination Phase 4
25 Dopamine Agents Phase 4
26 Dopamine agonists Phase 4
27 Potassium Channel Blockers Phase 4
28 Cytidine Diphosphate Choline Phase 4
29 Nootropic Agents Phase 4
30 Phosphodiesterase 5 Inhibitors Phase 4
31 Phosphodiesterase Inhibitors Phase 4,Phase 2
32 Sildenafil Citrate Phase 4 171599-83-0
33 Vardenafil Dihydrochloride Phase 4
34 Adrenergic Agonists Phase 4
35 Adrenergic alpha-2 Receptor Agonists Phase 4
36 Adrenergic alpha-Agonists Phase 4
37 Brimonidine Tartrate Phase 4 70359-46-5
38 Carboxymethylcellulose Sodium Phase 4
39 Cathartics Phase 4
40 Laxatives Phase 4
41 Nasal Decongestants Phase 4
42 Ophthalmic Solutions Phase 4
43 Pharmaceutical Solutions Phase 4,Phase 2
44 Respiratory System Agents Phase 4,Phase 2
45 Tetrahydrozoline Phase 4
46 Vasoconstrictor Agents Phase 4
47
Methylprednisolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 83-43-2 6741
48
Prednisolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 50-24-8 5755
49
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
50
Bosentan Approved, Investigational Phase 3 147536-97-8 104865

Interventional clinical trials:

(show top 50) (show all 54)
id Name Status NCT ID Phase
1 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4
2 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4
3 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4
4 Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4
5 Ophthalmic Findings During 10-year Enzyme Substitution of Danish Fabry Patients. Completed NCT01997489 Phase 4
6 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT00867815 Phase 4
7 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03046693 Phase 4
8 Preoperative Brimonidine on IOP of Patients Undergoing RALP Recruiting NCT02818816 Phase 4
9 Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02439866 Phase 3
10 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION Unknown status NCT02329288 Phase 3
11 Ischemic Optic Neuropathy Decompression Trial (IONDT) Completed NCT00000127 Phase 3
12 Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT02341560 Phase 2, Phase 3
13 Erythropoietin in Methanol Associated Optic Neuropathy: A Phase-2 Clinical Trial (EPO-MAON Study) Recruiting NCT02376881 Phase 3
14 ENDOTHELION Study Group: Effect of Bosentan in NAION Patients Not yet recruiting NCT02377271 Phase 3
15 Intravitreal Bevacizumab for Non-Arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2
16 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo Unknown status NCT01330524 Phase 1, Phase 2
17 Neurotomy of Optic Nerve in Non-Arthritic Anterior Ischemic Optic Neuropathy Completed NCT00372021 Phase 1, Phase 2
18 Safety and Efficacy Study of RPh201 Treatment of Ischemic Optic Neuropathy (ION). Completed NCT02045212 Phase 2
19 Effects of Moxaverine and Placebo on Ocular Blood Flow Completed NCT00709423 Phase 2
20 Traumatic Optic Neuropathy Treatment Trial (TONTT) Completed NCT01783847 Phase 1, Phase 2
21 Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non Arteritic Anterior Ischemic Optic Neuropathy Not yet recruiting NCT03173638 Phase 2
22 Intraocular Pressure During Prone Spinal Surgery Terminated NCT00176722 Phase 2
23 Role of Endothelin- and Nitric Oxide-system in the Regulation of Optic Nerve Head Blood Flow During Changes in Ocular Perfusion Pressure Withdrawn NCT00406731 Phase 2
24 Ranibizumab Therapy for Non-arteritic Ischemic Optic Neuropathy Completed NCT00561834 Phase 1
25 Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients Completed NCT01064505 Phase 1
26 NT-501 CNTF Implant for Ischemic Optic Neuropathy: Safety, Neuroprotection and Neuroenhancement Completed NCT01411657 Phase 1
27 A Phase I Clinical Trial of DARC Active, not recruiting NCT02394613 Phase 1
28 Treatment Study for Ischemic Optic Neuropathy With Opthalmic Timolol Maleate 0.5% Withdrawn NCT01607671 Phase 1
29 Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup) Unknown status NCT00000126
30 Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) Unknown status NCT00874913
31 Study on the Oxygen Saturation in Pulsating and Non-pulsating Central Retinal Veins Unknown status NCT01794442
32 A Study to Determine if There is a Possible Association Between Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) and Phosphodiesterase Type 5 (PDE5) Inhibitors Completed NCT01131104
33 Epidemiology Study of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01260324
34 Vision Restoration Therapy (VRT) to Treat Non-Arteritic Anterior Ischemic Optic Neuropathy Completed NCT00140491
35 Assessment of Visual Field-related Endpoints in Patients With Non-arteritic Ischemic Optic Neuropathy Completed NCT01614158
36 Intraocular Pressure During Abdominal Aortic Aneurysm (AAA) Repair Completed NCT00450294
37 Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours Completed NCT00875043
38 Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry Completed NCT01219569
39 Transcorneal Electrical Stimulation Therapy for Retinal Disease Completed NCT00804102
40 Validation of the GATE Software Completed NCT01265628
41 A Study to Assess Whether PDE5 Inhibitors Increase the Chance of Triggering the Onset of Acute NAION Completed NCT00759174
42 Validation of Retinal Oximetry in Glaucoma Patients: a Structural and Functional Correlation Completed NCT01391247
43 Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS) Completed NCT00610402
44 Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases Completed NCT02308579
45 Effect of EECP on Anterior Ischemic Optic Neuropathy Recruiting NCT01768260
46 Biomechanics of Optic Neuropathy Recruiting NCT02982499
47 Influence of Oral Treatment With Citicoline for the Prevention of Radiation Optic Neuropathy in Patients Treated for Uveal Melanomas With Proton Beam Therapy Recruiting NCT01338389
48 Stem Cell Ophthalmology Treatment Study II Recruiting NCT03011541
49 Stem Cell Ophthalmology Treatment Study Recruiting NCT01920867
50 Multimodel Magnetic Resonance Imaging (MRI)of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders Recruiting NCT02836327

Search NIH Clinical Center for Nonarteritic Anterior Ischemic Optic Neuropathy

Cochrane evidence based reviews: optic neuropathy, ischemic

Genetic Tests for Nonarteritic Anterior Ischemic Optic Neuropathy

Genetic tests related to Nonarteritic Anterior Ischemic Optic Neuropathy:

id Genetic test Affiliating Genes
1 Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 29
2 Nonarteritic Anterior Ischemic Optic Neuropathy 29

Anatomical Context for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards organs/tissues related to Nonarteritic Anterior Ischemic Optic Neuropathy:

39
Eye, Endothelial, Neutrophil, B Cells, Liver

Publications for Nonarteritic Anterior Ischemic Optic Neuropathy

Articles related to Nonarteritic Anterior Ischemic Optic Neuropathy:

(show top 50) (show all 209)
id Title Authors Year
1
Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28302535 )
2017
2
Relative Frequencies of Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy in an Arab Population. ( 28099197 )
2017
3
Neutrophil to Lymphocyte Ratio in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28367045 )
2017
4
Nonarteritic Anterior Ischemic Optic Neuropathy and Intraocular Surgery. ( 28108001 )
2017
5
Assessment of nonarteritic anterior ischemic optic neuropathy with intravoxel incoherent motion diffusion-weighted imaging using readout-segmented echo-planar imaging, parallel imaging, and 2D navigator-based reacquisition. ( 28513892 )
2017
6
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886887 )
2017
7
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective CohortA Study. ( 28063480 )
2017
8
Optical Coherence Tomography Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28301863 )
2017
9
Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28316838 )
2017
10
Perioperative nonarteritic anterior ischemic optic neuropathy in Jehovah's Witnesses. ( 28457303 )
2017
11
Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28438311 )
2017
12
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort Study. ( 28093100 )
2017
13
Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886893 )
2017
14
Prospective Case-crossover Study Investigating the Possible Association Between Nonarteritic Anterior Ischemic Optic Neuropathy and Phosphodiesterase Type 5 Inhibitor Exposure. ( 28336289 )
2017
15
Comparison of Visual Outcomes of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients with and without Diabetes Mellitus. ( 28017420 )
2016
16
Efficacy of Intravitreal Injections of Triamcinolone Acetonide in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27082303 )
2016
17
Trying to Understand Nonarteritic Anterior Ischemic Optic Neuropathy through Big Data. ( 27871391 )
2016
18
The Relationship Between Phosphodiesterase-5 Inhibitors and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 26720519 )
2016
19
The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION). ( 27911358 )
2016
20
Comparison of the Deep Optic Nerve Head Structure between Normal-Tension Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27035660 )
2016
21
Peripapillary Retinal Nerve Fiber Layer Swelling Predicts Peripapillary Atrophy in a Primate Model of Nonarteritic Anterior Ischemic Optic Neuropathy. ( 26868755 )
2016
22
Nonarteritic anterior ischemic optic neuropathy following pars plana vitrectomy for macular hole treatment: case report. ( 27982219 )
2016
23
Ganglion cell analysis at acute episode of nonarteritic anterior ischemic optic neuropathy to predict irreversible damage. A prospective study. ( 27422787 )
2016
24
Nonarteritic Anterior Ischemic Optic Neuropathy and Erectile Dysfunction Drugs: Is There an Elephant in the Bedroom? ( 27984350 )
2016
25
Optic Nerve Head Morphology in Nonarteritic Anterior Ischemic Optic Neuropathy Compared to Open-Angle Glaucoma. ( 27603724 )
2016
26
The enigma of nonarteritic anterior ischemic optic neuropathy: an update for the comprehensive ophthalmologist. ( 27585212 )
2016
27
A Nonarteritic Anterior Ischemic Optic Neuropathy Clinical Trial: An Industry and NORDIC Collaboration. ( 27389625 )
2016
28
Demographic, Systemic, and Ocular Factors Associated with Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27659545 )
2016
29
Are Erectile Dysfunction Medications Causally Related to Nonarteritic Anterior Ischemic Optic Neuropathy? ( 26828844 )
2016
30
Can Corneal Biomechanical Properties Give Clues About Elasticity of Optic Nerve Scleral Component in Nonarteritic Anterior Ischemic Optic Neuropathy? ( 27389626 )
2016
31
Does Nocturnal Hypotension Play a Causal Role in Nonarteritic Anterior Ischemic Optic Neuropathy? ( 27380214 )
2016
32
Sildenafil-Induced Nonarteritic Anterior Ischemic Optic Neuropathy in a Patient With Pulmonary Hypertension. ( 27533530 )
2016
33
Structural and Functional Analyses in Nonarteritic Anterior Ischemic Optic Neuropathy: Optical Coherence Tomography Angiography Study. ( 27984351 )
2016
34
Risk of Nonarteritic Anterior Ischemic Optic Neuropathy Following End-Stage Renal Disease. ( 27015205 )
2016
35
Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) in Polymyalgia Rheumatica. ( 27342326 )
2016
36
Mean Platelet Volume in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy. ( 26966556 )
2016
37
Analysis of Fundus Photography and Fluorescein Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis. ( 27478356 )
2016
38
Retinal Ganglion Cell Loss Precedes Retinal Nerve Fiber Thinning in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 26835663 )
2016
39
Peripapillary Pachychoroid in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27583829 )
2016
40
Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27128315 )
2016
41
A Single Intravitreal Injection of Ranibizumab Provides No Neuroprotection in a Nonhuman Primate Model of Moderate-to-Severe Nonarteritic Anterior Ischemic Optic Neuropathy. ( 26624498 )
2015
42
The Association Between Obstructive Sleep Apnea and Nonarteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis. ( 26443989 )
2015
43
Surgery for nonarteritic anterior ischemic optic neuropathy. ( 25763979 )
2015
44
Is there treatment for nonarteritic anterior ischemic optic neuropathy. ( 26367094 )
2015
45
Re: Parsa et al.: Nonarteritic anterior ischemic optic neuropathy (NAION): a misnomer. Rearranging pieces of a puzzle to reveal a nonischemic papillopathy caused by vitreous separation (Ophthalmology 2015;122:439-42). ( 26592684 )
2015
46
Simultaneous bilateral nonarteritic anterior ischemic optic neuropathy in a patient with a history of diffuse large B-cell lymphoma. ( 25829891 )
2015
47
Peripapillary choroidal thickness in nonarteritic anterior ischemic optic neuropathy. ( 25813991 )
2015
48
Nonarteritic anterior ischemic optic neuropathy (NAION): a misnomer. Rearranging pieces of a puzzle to reveal a nonischemic papillopathy caused by vitreous separation. ( 25703466 )
2015
49
Re: Parsa et al.: Nonarteritic anterior ischemic optic neuropathy (NAION): a misnomer. Rearranging pieces of a puzzle to reveal a nonischemic papillopathy caused by vitreous separation (Ophthalmology 2015;122:439-42). ( 26592683 )
2015
50
Levodopa as a possible treatment of visual loss in nonarteritic anterior ischemic optic neuropathy. ( 26483145 )
2015

Variations for Nonarteritic Anterior Ischemic Optic Neuropathy

ClinVar genetic disease variations for Nonarteritic Anterior Ischemic Optic Neuropathy:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GP1BA GP1BA, 92-BP DUP, SER399-THR411 DUP, VARIABLE REPEATS duplication risk factor

Expression for Nonarteritic Anterior Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Nonarteritic Anterior Ischemic Optic Neuropathy.

Pathways for Nonarteritic Anterior Ischemic Optic Neuropathy

Pathways related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 F2 GP1BA NOS3 PDE5A SERPINC1
2
Show member pathways
12.43 AGTR1 EDN1 F2 NOS3
3
Show member pathways
11.64 F2 GP1BA SERPINC1
4 11.13 AGTR1 EDN1 NOS3
5
Show member pathways
11.06 NOS3 PDE5A
6 10.94 EDN1 NOS3
7
Show member pathways
10.7 ACE AGTR1 NOS3
8 10.27 NOS3 PDE5A

GO Terms for Nonarteritic Anterior Ischemic Optic Neuropathy

Biological processes related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.76 EDN1 F2 GP1BA
2 blood coagulation GO:0007596 9.71 F2 GP1BA SERPINC1
3 response to amino acid GO:0043200 9.58 EDN1 MTHFR
4 blood vessel remodeling GO:0001974 9.57 ACE NOS3
5 positive regulation of reactive oxygen species metabolic process GO:2000379 9.56 AGTR1 F2
6 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.55 AGTR1 EDN1
7 fibrinolysis GO:0042730 9.52 F2 GP1BA
8 blood coagulation, intrinsic pathway GO:0007597 9.51 F2 GP1BA
9 regulation of blood vessel size GO:0050880 9.49 EDN1 NOS3
10 positive regulation of cardiac muscle hypertrophy GO:0010613 9.48 EDN1 PDE5A
11 regulation of vasodilation GO:0042312 9.46 ACE AGTR1
12 regulation of blood vessel diameter GO:0097746 9.43 ACE AGTR1
13 regulation of blood pressure GO:0008217 9.43 ACE EDN1 NOS3
14 negative regulation of platelet activation GO:0010544 9.4 F2 NOS3
15 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.37 EDN1 NOS3
16 hemostasis GO:0007599 9.33 F2 GP1BA SERPINC1
17 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.32 ACE AGTR1
18 regulation of vasoconstriction GO:0019229 9.13 ACE AGTR1 EDN1
19 regulation of blood coagulation GO:0030193 8.8 F2 GP1BA SERPINC1

Molecular functions related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 8.96 MTHFR NOS3
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Nonarteritic Anterior Ischemic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
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70 UMLS via Orphanet
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