MCID: NNR004
MIFTS: 52

Nonarteritic Anterior Ischemic Optic Neuropathy

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards integrated aliases for Nonarteritic Anterior Ischemic Optic Neuropathy:

Name: Nonarteritic Anterior Ischemic Optic Neuropathy 54 12 29 69
Anterior Ischemic Optic Neuropathy 12 50 71 14 69
Non-Arteritic Anterior Ischemic Optic Neuropathy 12 71 14
Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 29 13
Optic Neuropathy, Ischemic 42 69
Ischemic Optic Neuropathy 12 50
Naion 71 52
Aion 50 71

Characteristics:

OMIM:

54
Inheritance:
autosomal recessive


HPO:

32
nonarteritic anterior ischemic optic neuropathy:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 54 258660
Disease Ontology 12 DOID:0050864 DOID:12010
ICD10 33 H47.01
ICD9CM 35 377.41
MeSH 42 D018917
SNOMED-CT 64 14357004
MedGen 40 C1847711
SNOMED-CT via HPO 65 258211005
UMLS 69 C0155305

Summaries for Nonarteritic Anterior Ischemic Optic Neuropathy

NIH Rare Diseases : 50 anterior ischemic optic neuropathy (aion) is an eye disease characterized by infarction of the optic disk leading to vision loss. it can be nonarteritic (nonarteritic anterior ischemic optic neuropathy or naion) or arteritic, the latter being associated with giant cell arteritis (gca; often termed temporal arteritis).vision loss with both varieties is typically rapid (over minutes, hours, or days) and painless. symptoms such as a general feeling of being unwell (malaise), muscle aches and pains, headaches over the temple, pain when combing hair, pain in the jaw after chewing, and tenderness over the temporal artery (one of the major arteries of the head) may be present with giant cell arteritis. at exam, visual acuity is reduced and the optic disc is swollen. in both subtypes, visual field examination is often reduced in the inferior and central visual fields.the visual loss is usually permanent, with some recovery possibly occurring within the first weeks or months. the arteritic variety is treated with corticosteroids. treatment of the nonarteritic variety with aspirin or corticosteroids has not been helpful.  last updated: 10/21/2016

MalaCards based summary : Nonarteritic Anterior Ischemic Optic Neuropathy, also known as anterior ischemic optic neuropathy, is related to central retinal artery occlusion and arteritic anterior ischemic optic neuropathy. An important gene associated with Nonarteritic Anterior Ischemic Optic Neuropathy is GP1BA (Glycoprotein Ib Platelet Alpha Subunit), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Development Angiotensin activation of ERK. The drugs Carbidopa and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and liver, and related phenotypes are cardiovascular system and homeostasis/metabolism

UniProtKB/Swiss-Prot : 71 Non-arteritic anterior ischemic optic neuropathy: An ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage.

Wikipedia : 72 Anterior ischemic optic neuropathy (AION) is a medical condition involving loss of vision caused by... more...

Description from OMIM: 258660

Related Diseases for Nonarteritic Anterior Ischemic Optic Neuropathy

Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
id Related Disease Score Top Affiliating Genes
1 central retinal artery occlusion 30.3 F2 MTHFR SERPINC1
2 arteritic anterior ischemic optic neuropathy 12.4
3 ischemic optic neuropathy 11.1
4 neuropathy 11.1
5 pars planitis 10.6 ACE MTHFR
6 primary hyperoxaluria 10.5 ACE SERPINC1
7 retinitis 10.5
8 conjunctival disease 10.5 ACE SERPINC1
9 hypertonia 10.5 MTHFR NOS3
10 porphyria 10.5 F2 MTHFR
11 femoral neuropathy 10.5 MTHFR SERPINC1
12 lockwood feingold syndrome 10.5 F2 MTHFR
13 chronic diarrhea due to guanylate cyclase 2c overactivity 10.5 ACE SERPINC1
14 argyria 10.5 ACE F2
15 monocular exotropia 10.5 GP1BA SERPINC1
16 primary pigmented nodular adrenocortical disease 10.4 F2 MTHFR
17 pyogenic arthritis, pyoderma gangrenosum and acne 10.4 ACE PDE5A
18 homologous wasting disease 10.4 F2 MTHFR
19 parasitic helminthiasis infectious disease 10.4 ACE SERPINC1
20 pyridoxine deficiency anemia 10.4 F2 SERPINC1
21 fragile x syndrome type 2 10.4 F2 SERPINC1
22 myiasis 10.4 F2 SERPINC1
23 testicular gonadoblastoma 10.4 F2 SERPINC1
24 egg allergy 10.4 F2 SERPINC1
25 rectum neuroendocrine neoplasm 10.3 F2 SERPINC1
26 syndactyly, mesoaxial synostotic, with phalangeal reduction 10.3 F2 SERPINC1
27 pelvic inflammatory disease 10.3 ACE MTHFR
28 midline cystocele 10.3 F2 SERPINC1
29 littre gland carcinoma 10.3 F2 SERPINC1
30 lip disease 10.3 NOS3 PDE5A
31 sleep apnea 10.3
32 glutathioninuria 10.3 F2 SERPINC1
33 pilomyxoid astrocytoma 10.3 F2 SERPINC1
34 inferolateral myocardial infarct 10.3 F2 SERPINC1
35 angelucci's syndrome 10.3 F2 SERPINC1
36 lethal congenital contracture syndrome 10.3 F2 SERPINC1
37 c1 inhibitor deficiency 10.3 F2 GP1BA
38 lujo hemorrhagic fever 10.3 F2 SERPINC1
39 congenital syphilis 10.3 F2 SERPINC1
40 choroiditis 10.3
41 optic neuritis 10.3
42 neuritis 10.3
43 neuroaxonal dystrophy 10.3 F2 SERPINC1
44 childhood brain stem glioma 10.3 F2 SERPINC1
45 hepadnavirus infection 10.2 F2 SERPINC1
46 idiopathic juxtafoveal retinal telangiectasia 10.2 ACE EDN1
47 dyskeratosis congenita autosomal recessive 10.2 F2 SERPINC1
48 obstructive sleep apnea 10.2
49 progressive black carbon hyperpigmentation of infancy 10.2 EDN1 NOS3
50 focal dystonia 10.2 ACE NOS3

Comorbidity relations with Nonarteritic Anterior Ischemic Optic Neuropathy via Phenotypic Disease Network (PDN):


Hypertension, Essential Temporal Arteritis

Graphical network of the top 20 diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy:



Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy

Symptoms & Phenotypes for Nonarteritic Anterior Ischemic Optic Neuropathy

Symptoms via clinical synopsis from OMIM:

54

Eyes:
nonarteritic anterior ischemic optic neuropathy
papillophlebitis


Clinical features from OMIM:

258660

Human phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

32
id Description HPO Frequency HPO Source Accession
1 nonarteritic anterior ischemic optic neuropathy 32 HP:0007634

MGI Mouse Phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 ACE AGTR1 EDN1 F2 NOS3 SERPINC1
2 homeostasis/metabolism MP:0005376 9.56 ACE AGTR1 EDN1 F2 GP1BA MTHFR
3 renal/urinary system MP:0005367 9.02 EDN1 NOS3 SERPINC1 ACE AGTR1

Drugs & Therapeutics for Nonarteritic Anterior Ischemic Optic Neuropathy

Drugs for Nonarteritic Anterior Ischemic Optic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carbidopa Approved Phase 4 28860-95-9 34359 38101
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Levodopa Approved Phase 4 59-92-7 6047
4
4-Aminopyridine Approved Phase 4 504-24-5 1727
5
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
6
Choline Approved, Nutraceutical Phase 4 62-49-7 305
7 Cytidine Diphosphate Choline Phase 4
8 Nootropic Agents Phase 4
9 Adjuvants, Immunologic Phase 4
10 Antiparkinson Agents Phase 4
11 Aromatic Amino Acid Decarboxylase Inhibitors Phase 4
12 Carbidopa, levodopa drug combination Phase 4
13 Dopamine Agents Phase 4
14 Dopamine agonists Phase 4
15 Neurotransmitter Agents Phase 4,Phase 1
16 Potassium Channel Blockers Phase 4
17 Phosphodiesterase 5 Inhibitors Phase 4
18 Phosphodiesterase Inhibitors Phase 4
19 Sildenafil Citrate Phase 4 171599-83-0
20 Vardenafil Dihydrochloride Phase 4
21
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
22
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
23
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
24
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
25 Antiemetics Phase 3
26 Anti-Inflammatory Agents Phase 3,Phase 1,Phase 2
27 Antineoplastic Agents, Hormonal Phase 3
28 Autonomic Agents Phase 3
29 Gastrointestinal Agents Phase 3
30 glucocorticoids Phase 3,Phase 1,Phase 2
31 Hormone Antagonists Phase 3,Phase 1,Phase 2
32 Hormones Phase 3,Phase 1,Phase 2
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
34 Methylprednisolone acetate Phase 3
35 Methylprednisolone Hemisuccinate Phase 3
36 Neuroprotective Agents Phase 3,Phase 1
37 Peripheral Nervous System Agents Phase 3
38 Prednisolone acetate Phase 3
39 Prednisolone hemisuccinate Phase 3
40 Prednisolone phosphate Phase 3
41 Protective Agents Phase 3
42 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
43 triamcinolone acetonide Phase 3,Phase 1,Phase 2
44 Triamcinolone diacetate Phase 3,Phase 1,Phase 2
45 Triamcinolone hexacetonide Phase 3,Phase 1,Phase 2
46 Antihypertensive Agents Phase 3,Phase 1
47 Endothelin Receptor Antagonists Phase 3
48
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
49 Angiogenesis Inhibitors Phase 2,Phase 1
50 Angiogenesis Modulating Agents Phase 2,Phase 1

Interventional clinical trials:

(show all 25)

id Name Status NCT ID Phase Drugs
1 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
2 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
3 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
4 Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4 Cytidine-5’-diphosphocholine (Citicoline)
5 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT00867815 Phase 4 Diagnostic procedures
6 Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
7 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION Unknown status NCT02329288 Phase 3 Triamcinolone Acetonide;placebo
8 Ischemic Optic Neuropathy Decompression Trial (IONDT) Completed NCT00000127 Phase 3
9 Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - single low dose;QPI-1007 Injection - single high dose;QPI-1007 Injection - multiple low dose;QPI-1007 Injection - multiple high dose
10 ENDOTHELION Study Group: Effect of Bosentan in NAION Patients Recruiting NCT02377271 Phase 3 bosentan;placebo
11 Intravitreal Bevacizumab for Non-Arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
12 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo Unknown status NCT01330524 Phase 1, Phase 2 Avastin and Triamcinolone
13 Safety and Efficacy Study of RPh201 Treatment of Ischemic Optic Neuropathy (ION). Completed NCT02045212 Phase 2 RPh201;Placebo
14 Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non Arteritic Anterior Ischemic Optic Neuropathy Not yet recruiting NCT03173638 Phase 2
15 A Phase I Clinical Trial of DARC Unknown status NCT02394613 Phase 1 ANX776
16 Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients Completed NCT01064505 Phase 1 QPI-1007 at various doses
17 Ranibizumab Therapy for Non-arteritic Ischemic Optic Neuropathy Completed NCT00561834 Phase 1 ranibizumab
18 Treatment Study for Ischemic Optic Neuropathy With Opthalmic Timolol Maleate 0.5% Withdrawn NCT01607671 Phase 1 Timolol maleate
19 Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup) Unknown status NCT00000126
20 Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) Unknown status NCT00874913
21 A Study to Determine if There is a Possible Association Between Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) and Phosphodiesterase Type 5 (PDE5) Inhibitors Completed NCT01131104 PDE5 Inhibitors
22 Vision Restoration Therapy (VRT) to Treat Non-Arteritic Anterior Ischemic Optic Neuropathy Completed NCT00140491
23 Epidemiology Study of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01260324
24 Assessment of Visual Field-related Endpoints in Patients With Non-arteritic Ischemic Optic Neuropathy Completed NCT01614158
25 Electric Stimulation of the Eye to Improve Vision After Trauma Active, not recruiting NCT02019927

Search NIH Clinical Center for Nonarteritic Anterior Ischemic Optic Neuropathy

Cochrane evidence based reviews: optic neuropathy, ischemic

Genetic Tests for Nonarteritic Anterior Ischemic Optic Neuropathy

Genetic tests related to Nonarteritic Anterior Ischemic Optic Neuropathy:

id Genetic test Affiliating Genes
1 Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 29
2 Nonarteritic Anterior Ischemic Optic Neuropathy 29

Anatomical Context for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards organs/tissues related to Nonarteritic Anterior Ischemic Optic Neuropathy:

39
Eye, Endothelial, Liver, Neutrophil, B Cells

Publications for Nonarteritic Anterior Ischemic Optic Neuropathy

Articles related to Nonarteritic Anterior Ischemic Optic Neuropathy:

(show top 50) (show all 218)
id Title Authors Year
1
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy: Response. ( 28759500 )
2017
2
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective CohortA Study. ( 28063480 )
2017
3
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28759499 )
2017
4
Dalfampridine Treatment in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28538037 )
2017
5
Automated Evaluation of Choroidal Thickness and Minimum Rim Width Thickness in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28885450 )
2017
6
Neutrophil to Lymphocyte Ratio in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28367045 )
2017
7
Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations. ( 28846776 )
2017
8
Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886893 )
2017
9
Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28438311 )
2017
10
Optical Coherence Tomography Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28301863 )
2017
11
Does Nocturnal Hypotension Play a Causal Role in Nonarteritic Anterior Ischemic Optic Neuropathy?: Response. ( 28742641 )
2017
12
Comparison of the Retinal Microvascular Density Between Open Angle Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28687846 )
2017
13
Role of Nocturnal Arterial Hypotension in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28742640 )
2017
14
Assessment of nonarteritic anterior ischemic optic neuropathy with intravoxel incoherent motion diffusion-weighted imaging using readout-segmented echo-planar imaging, parallel imaging, and 2D navigator-based reacquisition. ( 28513892 )
2017
15
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort Study. ( 28093100 )
2017
16
Perioperative nonarteritic anterior ischemic optic neuropathy in Jehovah's Witnesses. ( 28457303 )
2017
17
Nonarteritic Anterior Ischemic Optic Neuropathy and Intraocular Surgery. ( 28108001 )
2017
18
Relative Frequencies of Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy in an Arab Population. ( 28099197 )
2017
19
Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28316838 )
2017
20
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886887 )
2017
21
Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28302535 )
2017
22
Structure-Function Analysis of Nonarteritic Anterior Ischemic Optic Neuropathy and Age-Related Differences in Outcome. ( 28538035 )
2017
23
Prospective Case-crossover Study Investigating the Possible Association Between Nonarteritic Anterior Ischemic Optic Neuropathy and Phosphodiesterase Type 5 Inhibitor Exposure. ( 28336289 )
2017
24
Comparison of the Deep Optic Nerve Head Structure between Normal-Tension Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27035660 )
2016
25
Nonarteritic Anterior Ischemic Optic Neuropathy and Erectile Dysfunction Drugs: Is There an Elephant in the Bedroom? ( 27984350 )
2016
26
The enigma of nonarteritic anterior ischemic optic neuropathy: an update for the comprehensive ophthalmologist. ( 27585212 )
2016
27
Optic Nerve Head Morphology in Nonarteritic Anterior Ischemic Optic Neuropathy Compared to Open-Angle Glaucoma. ( 27603724 )
2016
28
The Relationship Between Phosphodiesterase-5 Inhibitors and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 26720519 )
2016
29
A Nonarteritic Anterior Ischemic Optic Neuropathy Clinical Trial: An Industry and NORDIC Collaboration. ( 27389625 )
2016
30
Comparison of Visual Outcomes of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients with and without Diabetes Mellitus. ( 28017420 )
2016
31
Peripapillary Retinal Nerve Fiber Layer Swelling Predicts Peripapillary Atrophy in a Primate Model of Nonarteritic Anterior Ischemic Optic Neuropathy. ( 26868755 )
2016
32
Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) in Polymyalgia Rheumatica. ( 27342326 )
2016
33
The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION). ( 27911358 )
2016
34
Mean Platelet Volume in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy. ( 26966556 )
2016
35
Dendrimers Target the Ischemic Lesion in Rodent and Primate Models of Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27128315 )
2016
36
Structural and Functional Analyses in Nonarteritic Anterior Ischemic Optic Neuropathy: Optical Coherence Tomography Angiography Study. ( 27984351 )
2016
37
Sildenafil-Induced Nonarteritic Anterior Ischemic Optic Neuropathy in a Patient With Pulmonary Hypertension. ( 27533530 )
2016
38
Are Erectile Dysfunction Medications Causally Related to Nonarteritic Anterior Ischemic Optic Neuropathy? ( 26828844 )
2016
39
Can Corneal Biomechanical Properties Give Clues About Elasticity of Optic Nerve Scleral Component in Nonarteritic Anterior Ischemic Optic Neuropathy? ( 27389626 )
2016
40
Trying to Understand Nonarteritic Anterior Ischemic Optic Neuropathy through Big Data. ( 27871391 )
2016
41
Demographic, Systemic, and Ocular Factors Associated with Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27659545 )
2016
42
Risk of Nonarteritic Anterior Ischemic Optic Neuropathy Following End-Stage Renal Disease. ( 27015205 )
2016
43
Analysis of Fundus Photography and Fluorescein Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis. ( 27478356 )
2016
44
Ganglion cell analysis at acute episode of nonarteritic anterior ischemic optic neuropathy to predict irreversible damage. A prospective study. ( 27422787 )
2016
45
Nonarteritic anterior ischemic optic neuropathy following pars plana vitrectomy for macular hole treatment: case report. ( 27982219 )
2016
46
Efficacy of Intravitreal Injections of Triamcinolone Acetonide in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27082303 )
2016
47
Peripapillary Pachychoroid in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27583829 )
2016
48
Does Nocturnal Hypotension Play a Causal Role in Nonarteritic Anterior Ischemic Optic Neuropathy? ( 27380214 )
2016
49
Retinal Ganglion Cell Loss Precedes Retinal Nerve Fiber Thinning in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 26835663 )
2016
50
Peripapillary choroidal thickness in nonarteritic anterior ischemic optic neuropathy. ( 25813991 )
2015

Variations for Nonarteritic Anterior Ischemic Optic Neuropathy

ClinVar genetic disease variations for Nonarteritic Anterior Ischemic Optic Neuropathy:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GP1BA GP1BA, 92-BP DUP, SER399-THR411 DUP, VARIABLE REPEATS duplication risk factor

Expression for Nonarteritic Anterior Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Nonarteritic Anterior Ischemic Optic Neuropathy.

Pathways for Nonarteritic Anterior Ischemic Optic Neuropathy

GO Terms for Nonarteritic Anterior Ischemic Optic Neuropathy

Biological processes related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.75 EDN1 F2 GP1BA
2 blood coagulation GO:0007596 9.7 F2 GP1BA SERPINC1
3 response to amino acid GO:0043200 9.57 EDN1 MTHFR
4 blood vessel remodeling GO:0001974 9.56 ACE NOS3
5 positive regulation of reactive oxygen species metabolic process GO:2000379 9.55 AGTR1 F2
6 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.54 AGTR1 EDN1
7 fibrinolysis GO:0042730 9.51 F2 GP1BA
8 regulation of blood pressure GO:0008217 9.5 ACE EDN1 NOS3
9 positive regulation of cardiac muscle hypertrophy GO:0010613 9.49 EDN1 PDE5A
10 blood coagulation, intrinsic pathway GO:0007597 9.48 F2 GP1BA
11 regulation of blood vessel size GO:0050880 9.46 EDN1 NOS3
12 regulation of blood vessel diameter GO:0097746 9.43 ACE AGTR1
13 negative regulation of platelet activation GO:0010544 9.4 F2 NOS3
14 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.37 ACE AGTR1
15 hemostasis GO:0007599 9.33 F2 GP1BA SERPINC1
16 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.26 EDN1 NOS3
17 regulation of vasoconstriction GO:0019229 9.13 ACE AGTR1 EDN1
18 regulation of blood coagulation GO:0030193 8.8 F2 GP1BA SERPINC1

Molecular functions related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 8.96 MTHFR NOS3
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Nonarteritic Anterior Ischemic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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