MCID: NNS011
MIFTS: 35

Nonseminomatous Germ Cell Tumor malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Nonseminomatous Germ Cell Tumor

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Nonseminomatous Germ Cell Tumor, Aliases & Descriptions:

Name: Nonseminomatous Germ Cell Tumor 41 60
Non-Seminomatous Germ-Cell Tumors 41
 
Nsgct 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Summaries for Nonseminomatous Germ Cell Tumor

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NIH Rare Diseases:41 Nonseminomatous germ cell tumors are cancerous tumors commonly found in the pineal gland in the brain, in the mediastinum, or in the abdomen. they originate from cells that were meant to form sex cells (i.e., sperm or eggs). they are often large and have a tendency to spread more quickly than the other type of germ cell tumor (i.e., seminoma type). possible early signs of this cancer include chest pain and breathing problems. last updated: 10/17/2013

MalaCards based summary: Nonseminomatous Germ Cell Tumor, also known as non-seminomatous germ-cell tumors, is related to endodermal sinus tumor and teratoma. An important gene associated with Nonseminomatous Germ Cell Tumor is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Glucocorticoid receptor regulatory network and Selected targets of Oct 3 4. The compounds 11-ketotestosterone and organon have been mentioned in the context of this disorder. Affiliated tissues include testis, brain and pineal, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Related Diseases for Nonseminomatous Germ Cell Tumor

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Diseases related to Nonseminomatous Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1endodermal sinus tumor31.2AFP
2teratoma30.7CGA, CGB7, CGB5, AFP, CGB
3germ cell cancer30.6CGA, AFP
4gynecomastia30.6CGA, CGB5
5hyperthyroidism30.4CGB, CGA, CGB5
6placental site trophoblastic tumor30.4CGA, CGB, CGB5
7testicular cancer30.1CGB5, CGB, AFP, CGA
8choriocarcinoma30.0AFP, CGA, CGB7, CGB, CGB5
9seminoma29.9CGB, CGA, AFP, CGB5, CGB7
10mediastinitis10.9
11testicular non seminomatous germ cell tumor10.9
12extragonadal nonseminomatous germ cell tumor10.7
13mature teratoma10.7
14growing teratoma syndrome10.7
15neuroectodermal tumor10.5
16prostatitis10.5
17oligohydramnios10.4AFP
18testicular germ cell tumor10.4
19pericarditis10.4
20rhabdomyosarcoma10.4
21hemolytic anemia10.3
22leukemia10.3
23thrombocytopenia10.3
24malignant teratoma10.3
25mental retardation10.3
26seizure disorder10.3
27extragonadal germ cell tumor10.2CGB5, AFP
28malignant mixed mullerian tumor10.2ERBB2, AFP
29tubular adenocarcinoma10.2ERBB2, AFP
30large cell carcinoma10.1CGB5, ERBB2
31bladder cancer, somatic10.1ERBB2, CGB
32anencephaly10.1CGA, AFP
33testicular teratoma10.1AFP, CGA
34ovarian mixed germ cell neoplasm10.1CGA, AFP
35cryptococcosis10.1CGB5, CGB7, CGB
36edwards syndrome10.1CGA, AFP
37turner syndrome10.1CGB, CGA
38leydig cell tumor10.1CGA, CGB5
39factor v leiden thrombophilia10.1CGB, CGB5, CGB7
40gastric adenocarcinoma10.0CGB7, ERBB2, AFP
41trophoblastic neoplasm10.0CGA, CGB5
42ovarian cyst10.0CGB5, CGA
43ovarian hyperstimulation syndrome10.0CGB5, CGA
44cholangiocarcinoma10.0ERBB2, AFP, CGB
45klinefelter's syndrome10.0CGB, CGA
46oligospermia10.0CGB5, CGA
47prolactinoma10.0CGA, CGB
48precocious puberty10.0CGB5, CGA
49kallmann syndrome10.0CGB5, CGA
50pregnancy loss, recurrent 110.0CGA, CGB5

Graphical network of the top 20 diseases related to Nonseminomatous Germ Cell Tumor:



Diseases related to nonseminomatous germ cell tumor

Symptoms for Nonseminomatous Germ Cell Tumor

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Drugs & Therapeutics for Nonseminomatous Germ Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Nonseminomatous Germ Cell Tumor

Search NIH Clinical Center for Nonseminomatous Germ Cell Tumor

Genetic Tests for Nonseminomatous Germ Cell Tumor

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Anatomical Context for Nonseminomatous Germ Cell Tumor

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MalaCards organs/tissues related to Nonseminomatous Germ Cell Tumor:

31
Testis, Brain, Pineal, Lymph node, Testes, Prostate, Bone, Ovary

Animal Models for Nonseminomatous Germ Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Nonseminomatous Germ Cell Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5CGA, ERBB2, APAF1, AFP
2MP:00053798.2CGA, ERBB2, APAF1, AFP

Publications for Nonseminomatous Germ Cell Tumor

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Articles related to Nonseminomatous Germ Cell Tumor:

(show top 50)    (show all 143)
idTitleAuthorsYear
1
Primary nonseminomatous germ cell tumor in the posterior mediastinum. (25473562)
2014
2
Treatment outcome of patients with extragonadal nonseminomatous germ cell tumors: the Saitama Cancer Center experience. (22763659)
2013
3
Nonseminomatous germ cell tumor of testis and interrupted treatment. (24133836)
2013
4
Salvage therapy with high-dose chemotherapy and peripheral blood stem cell transplant in patients with primary mediastinal nonseminomatous germ cell tumors. (22892555)
2013
5
Correlation between retroperitoneal lymph node size and presence of metastases in nonseminomatous germ cell tumors. (22180527)
2012
6
Extraperitoneal laparoscopic retroperitoneal lymph node dissection for early-stage testicular nonseminomatous germ cell tumors: initial experience. (22524310)
2012
7
Words of wisdom. Re: management of disseminated nonseminomatous germ cell tumors with risk-based chemotherapy followed by response-guided postchemotherapy surgery. (21524725)
2011
8
Stage I nonseminomatous germ cell tumor of the testis: more questions than answers? (21570606)
2011
9
Management of residual mass in nonseminomatous germ cell tumors following chemotherapy. (21969846)
2011
10
Secondary malignancies among nonseminomatous germ cell tumor cancer survivors. (21412759)
2011
11
Influence of suboptimal treatment in patients with mediastinal primary nonseminomatous germ cell tumors. (20185939)
2010
12
Management of good-risk metastatic nonseminomatous germ cell tumors of the testis: current concepts and controversies. (20535293)
2010
13
Laparoscopic retroperitoneal lymph node dissection with therapeutic intent in men with clinical stage I nonseminomatous germ cell tumors. (20879859)
2010
14
Nonseminomatous germ cell tumor of the testes metastatic to the corpus cavernosum of the penis. (19931126)
2010
15
Thoracic metastasectomy for nonseminomatous germ cell tumors. (20502259)
2010
16
High-risk clinical stage I nonseminomatous germ cell tumors: the case for chemotherapy. (19636566)
2009
17
Cisplatin-based chemotherapy followed by surgery for malignant nonseminomatous germ cell tumor of mediastinum: one institution's experience. (19597926)
2009
18
Nonseminomatous germ cell tumor with seizure disorder and mental retardation. (20531999)
2009
19
Postchemotherapy laparoscopic retroperitoneal lymph node dissection in nonseminomatous germ-cell tumor. (19335332)
2009
20
Laparoscopic retroperitoneal lymph node dissection for nonseminomatous germ cell tumors: long-term oncologic outcomes. (18303540)
2008
21
Nonseminomatous germ cell tumor of the testis 9 years after a germ cell tumor of the pineal gland: case report and review of the literature. (18570724)
2008
22
Efficacy of modified retroperitoneal lymph node dissection for testicular nonseminomatous germ cell tumors]. (19079998)
2008
23
Metastatic malignant teratoma arising from mediastinal nonseminomatous germ cell tumor: a case report. (18472634)
2008
24
Isolated solitary bony metastasis of a nonseminomatous germ cell tumor. (17324327)
2007
25
Incidence of metastatic nonseminomatous germ cell tumor outside the boundaries of a modified postchemotherapy retroperitoneal lymph node dissection. (17906201)
2007
26
Does the presence of extranodal extension in pathological stage B1 nonseminomatous germ cell tumor necessitate adjuvant chemotherapy? (17296383)
2007
27
Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor. (18071871)
2007
28
Quality of life after laparoscopic and open retroperitoneal lymph node dissection in clinical Stage I nonseminomatous germ cell tumor: a comparison study. (16820195)
2006
29
Phase II study of oxaliplatin and gemcitabine salvage chemotherapy in patients with cisplatin-refractory nonseminomatous germ cell tumor. (16757095)
2006
30
Images in neuro-oncology: brain metastases and leptomeningeal dissemination of nonseminomatous germ cell tumor. (15933818)
2005
31
Intracaval and intracardiac metastatic nonseminomatous germ cell tumor: a rare cause of hemolytic anemia and thrombocytopenia. (12449733)
2002
32
Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor. (11407397)
2001
33
Drug dose delivery and treatment outcome relationship in standard bleomycin, etoposide and cisplatin combination chemotherapy in nonseminomatous germ cell tumor patients. (10613596)
1999
34
Compliance of clinical stage I nonseminomatous germ cell tumor patients with surveillance. (9720544)
1998
35
Is serum tumor marker half-life a guide to prognosis in metastatic nonseminomatous germ cell tumors? (9329598)
1997
36
Discordance between the site of primary nonseminomatous germ cell tumor of the testis and retroperitoneal metastatic disease secondary to anomalous venous drainage of the testis. (8632590)
1996
37
Recurrence of a nonseminomatous germ cell tumor 9 years postoperatively: is surveillance alone acceptable? (7853563)
1995
38
Mature teratoma metastatic from nonseminomatous germ cell tumor. (8311644)
1994
39
Laparoscopic retroperitoneal lymphadenectomy for high-risk stage 1 nonseminomatous germ cell tumor: report of four cases. (8165782)
1994
40
Surgical resection in patients with nonseminomatous germ cell tumor who fail to normalize serum tumor markers after chemotherapy. (7506856)
1994
41
The growing teratoma syndrome: a woman with nonseminomatous germ cell tumor of the ovary. (8314544)
1993
42
Cytogenetic analysis of the mature teratoma and the choriocarcinoma component of a testicular mixed nonseminomatous germ cell tumor. (1638483)
1992
43
Extragonadal and poor risk nonseminomatous germ cell tumors. Survival and prognostic features. (1848473)
1991
44
Serum tumor marker half-life during chemotherapy allows early prediction of complete response and survival in nonseminomatous germ cell tumors. (1697503)
1990
45
Observation after orchiectomy in clinical stage I nonseminomatous germ cell tumor of testis. Mayo Clinic experience. (2171316)
1990
46
The growing teratoma syndrome. A case of primary mediastinal nonseminomatous germ cell tumor treated with chemotherapy and radiotherapy. (1694474)
1990
47
A third option in the management of patients with clinical stage I nonseminomatous germ cell tumor? (2153195)
1990
48
Nonseminomatous germ cell tumor of the testicle: does extensive staging of the primary tumor predict the likelihood of metastatic disease? (3016346)
1986
49
Indolent nonseminomatous germ cell tumor of testis. Prolonged survival of patient with persistent metastatic disease. (3008399)
1986
50
Primary nonseminomatous germ cell tumor of the prostate. (3944917)
1986

Variations for Nonseminomatous Germ Cell Tumor

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Expression for genes affiliated with Nonseminomatous Germ Cell Tumor

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Search GEO for disease gene expression data for Nonseminomatous Germ Cell Tumor.

Pathways for genes affiliated with Nonseminomatous Germ Cell Tumor

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Pathways related to Nonseminomatous Germ Cell Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5AFP, CGA
2
Show member pathways
9.1CGB5, CGA, CGB
3
Show member pathways
9.1CGB5, CGA, CGB

Compounds for genes affiliated with Nonseminomatous Germ Cell Tumor

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Compounds related to Nonseminomatous Germ Cell Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
111-ketotestosterone439.8CGB5, CGA
2organon439.7CGA, CGB5
3trilostane43 1210.7CGB5, CGA
4estradiol benzoate439.7CGB5, CGA
5leuprolide43 59 28 1212.7CGA, CGB5
617-hydroxypregnenolone439.7CGB5, CGA
7dihydroprogesterone439.6CGA, CGB5
8cetrorelix43 28 1211.6CGB5, CGA
98-bromo-cyclic amp439.5CGA, CGB5
1022r-hydroxycholesterol43 2810.5CGB5, CGA
11vincristine43 49 1211.5AFP, CGB, CGB5
12leuprolide acetate439.4CGB5, CGA
13androstenedione43 2410.4CGB5, CGA, CGB
14diethylstilbestrol43 28 1211.4AFP, CGA, CGB5
15vinblastine43 49 1211.4CGB5, CGA, AFP
16buserelin43 28 1211.3CGB5, CGA
17leucovorin43 49 1211.3ERBB2, CGB5, CGB
18carboplatin43 49 1211.3CGA, ERBB2, AFP
19dmso439.2CGA, AFP, CGB5
20progestin439.1ERBB2, CGB5, CGA
21clomiphene citrate439.1CGB5, CGA, AFP, CGB
22ifosfamide43 1210.1CGB5, CGA, AFP, CGB
23mifepristone43 28 59 1212.1CGB, CGB5, CGA, AFP
24creatinine439.0CGA, AFP, CGB, CGB5
25paclitaxel43 49 1210.8APAF1, AFP, ERBB2, CGB5
26folate438.8CGB5, CGA, ERBB2, AFP
27epinephrine43 24 1210.8AFP, CGA, ERBB2, CGB5
28aspartate438.8CGA, ERBB2, AFP, APAF1
29paraffin438.8ERBB2, AFP, CGB5, CGA
30thyroxine43 249.8CGB, CGA, CGB7, AFP
31dexamethasone43 49 28 1211.7AFP, CGB5, ERBB2, APAF1
32ctp438.7CGA, CGB5, CGB7, CGB
33alanine438.5CGA, ERBB2, AFP, CGB
34aspirin43 49 28 2411.5CGA, CGB5, ERBB2
35cyclophosphamide43 49 1210.5CGB5, AFP, CGB, CGA, ERBB2
36estrogen438.4CGB5, CGA, ERBB2, AFP, CGB
37doxorubicin43 49 1210.4AFP, CGB5, ERBB2, APAF1, CGA
38h2o2438.3AFP, ERBB2, CGB5, APAF1, CGA
39steroid438.3APAF1, ERBB2, CGA, CGB5, AFP
40oestriol438.3CGB7, AFP, CGB, CGB5, CGA
41bleomycin43 129.3CGA, CGB, AFP, CGB7, CGB5
42estradiol43 24 1210.2CGB, CGB5, CGB7, CGA, AFP
43gnrh438.0ERBB2, CGB, CGA, CGB7, CGB5
44vegf438.0CGB5, ERBB2, AFP, CGB, APAF1, CGA
45methotrexate49 43 129.6AFP, CGB7, CGA, ERBB2, CGB, CGB5
46lactate437.6ERBB2, CGA, CGB7, CGB, CGB5, AFP
47progesterone43 28 59 24 1211.6CGB7, CGA, CGB, ERBB2, AFP, CGB5
48testosterone43 59 24 1210.6AFP, ERBB2, CGB, CGA, CGB7, CGB5
49etoposide43 49 59 1210.2CGB7, CGA, CGB, ERBB2, APAF1, AFP
50cisplatin43 49 59 1210.2APAF1, ERBB2, CGB, CGA, CGB5, AFP

GO Terms for genes affiliated with Nonseminomatous Germ Cell Tumor

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Biological processes related to Nonseminomatous Germ Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:00164869.6CGA, CGB

Molecular functions related to Nonseminomatous Germ Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.6CGA, CGB

Products for genes affiliated with Nonseminomatous Germ Cell Tumor

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Sources for Nonseminomatous Germ Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet