NSGCT
MCID: NNS011
MIFTS: 42

Nonseminomatous Germ Cell Tumor (NSGCT) malady

Rare diseases, Cancer diseases categories
Download this MalaCard

Summaries for Nonseminomatous Germ Cell Tumor

About this section


Fully expand this MalaCard
NIH Rare Diseases:42 Nonseminomatous germ cell tumors are cancerous tumors commonly found in the pineal gland in the brain, in the mediastinum, or in the abdomen. they originate from cells that were meant to form sex cells (i.e., sperm or eggs). they are often large and have a tendency to spread more quickly than the other type of germ cell tumor (i.e., seminoma type). possible early signs of this cancer include chest pain and breathing problems. last updated: 10/17/2013

MalaCards based summary: Nonseminomatous Germ Cell Tumor, also known as non-seminomatous germ-cell tumors, is related to endodermal sinus tumor and teratoma. An important gene associated with Nonseminomatous Germ Cell Tumor is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Glucocorticoid receptor regulatory network and Selected targets of Oct 3 4. The compounds 11-ketotestosterone and organon have been mentioned in the context of this disorder. Affiliated tissues include testis, brain and pineal, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Aliases & Classifications for Nonseminomatous Germ Cell Tumor

About this section

Nonseminomatous Germ Cell Tumor, Aliases & Descriptions:

Name: Nonseminomatous Germ Cell Tumor 42 62
Non-Seminomatous Germ-Cell Tumors 42 62
 
Nsgct 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Nonseminomatous Germ Cell Tumor

About this section

Diseases related to Nonseminomatous Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1endodermal sinus tumor31.2AFP
2teratoma30.7CGA, CGB7, CGB5, AFP, CGB
3male germ cell tumor, somatic30.7AFP, CGA
4germ cell cancer30.6CGA, AFP
5gynecomastia30.6CGA, CGB5
6hyperthyroidism30.4CGB, CGA, CGB5
7placental site trophoblastic tumor30.4CGA, CGB, CGB5
8testicular cancer30.1CGB5, CGB, AFP, CGA
9choriocarcinoma30.1AFP, CGA, CGB7, CGB, CGB5
10seminoma29.9CGB, CGA, AFP, CGB5, CGB7
11germ cell tumors11.4
12mediastinitis10.9
13extragonadal nonseminomatous germ cell tumor10.6
14mature teratoma10.6
15growing teratoma syndrome10.6
16neuroectodermal tumor10.5
17prostatitis10.5
18oligohydramnios10.4AFP
19pericarditis10.4
20rhabdomyosarcoma10.4
21testicular germ cell tumor10.4
22hemolytic anemia10.3
23leukemia10.3
24renal cell carcinoma10.3
25thrombocytopenia10.3
26malignant teratoma10.3
27mental retardation10.3
28seizure disorder10.3
29extragonadal germ cell tumor10.2CGB5, AFP
30malignant mixed mullerian tumor10.2ERBB2, AFP
31tubular adenocarcinoma10.2ERBB2, AFP
32large cell carcinoma10.1CGB5, ERBB2
33bladder carcinoma10.1ERBB2, CGB
34anencephaly10.1CGA, AFP
35cryptococcosis10.1CGB5, CGB7, CGB
36edwards syndrome10.1CGA, AFP
37turner syndrome10.1CGB, CGA
38leydig cell tumor10.1CGA, CGB5
39factor v leiden thrombophilia10.1CGB, CGB5, CGB7
40gastric adenocarcinoma10.1CGB7, ERBB2, AFP
41trophoblastic neoplasm10.1CGA, CGB5
42ovarian cyst10.0CGB5, CGA
43ovarian hyperstimulation syndrome10.0CGB5, CGA
44klinefelter's syndrome10.0CGB, CGA
45cholangiocarcinoma10.0ERBB2, AFP, CGB
46oligospermia10.0CGB5, CGA
47prolactinoma10.0CGA, CGB
48precocious puberty10.0CGB5, CGA
49kallmann syndrome10.0CGB5, CGA
50cryptorchidism10.0CGB5, CGA

Graphical network of the top 20 diseases related to Nonseminomatous Germ Cell Tumor:



Diseases related to nonseminomatous germ cell tumor

Symptoms for Nonseminomatous Germ Cell Tumor

About this section

Drugs & Therapeutics for Nonseminomatous Germ Cell Tumor

About this section

Drug clinical trials:

Search ClinicalTrials for Nonseminomatous Germ Cell Tumor

Search NIH Clinical Center for Nonseminomatous Germ Cell Tumor

Genetic Tests for Nonseminomatous Germ Cell Tumor

About this section

Anatomical Context for Nonseminomatous Germ Cell Tumor

About this section

MalaCards organs/tissues related to Nonseminomatous Germ Cell Tumor:

32
Testis, Brain, Pineal, Lymph node, Testes, Prostate, Bone, Ovary

Animal Models for Nonseminomatous Germ Cell Tumor or affiliated genes

About this section

MGI Mouse Phenotypes related to Nonseminomatous Germ Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5CGA, ERBB2, APAF1, AFP
2MP:00053798.2CGA, ERBB2, APAF1, AFP

Publications for Nonseminomatous Germ Cell Tumor

About this section

Articles related to Nonseminomatous Germ Cell Tumor:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Treatment outcome of patients with extragonadal nonseminomatous germ cell tumors: the Saitama Cancer Center experience. (22763659)
2013
2
Nonseminomatous germ cell tumor of testis and interrupted treatment. (24133836)
2013
3
Bilateral laparoscopic postchemotherapy retroperitoneal lymph-node dissection in nonseminomatous germ cell tumors--a comparison to template dissection. (23516988)
2013
4
Correlation between retroperitoneal lymph node size and presence of metastases in nonseminomatous germ cell tumors. (22180527)
2012
5
Extraperitoneal laparoscopic retroperitoneal lymph node dissection for early-stage testicular nonseminomatous germ cell tumors: initial experience. (22524310)
2012
6
Words of wisdom. Re: management of disseminated nonseminomatous germ cell tumors with risk-based chemotherapy followed by response-guided postchemotherapy surgery. (21524725)
2011
7
Stage I nonseminomatous germ cell tumor of the testis: more questions than answers? (21570606)
2011
8
Management of residual mass in nonseminomatous germ cell tumors following chemotherapy. (21969846)
2011
9
Secondary malignancies among nonseminomatous germ cell tumor cancer survivors. (21412759)
2011
10
Influence of suboptimal treatment in patients with mediastinal primary nonseminomatous germ cell tumors. (20185939)
2010
11
Management of good-risk metastatic nonseminomatous germ cell tumors of the testis: current concepts and controversies. (20535293)
2010
12
Laparoscopic retroperitoneal lymph node dissection with therapeutic intent in men with clinical stage I nonseminomatous germ cell tumors. (20879859)
2010
13
Nonseminomatous germ cell tumor of the testes metastatic to the corpus cavernosum of the penis. (19931126)
2010
14
Thoracic metastasectomy for nonseminomatous germ cell tumors. (20502259)
2010
15
High-risk clinical stage I nonseminomatous germ cell tumors: the case for chemotherapy. (19636566)
2009
16
Cisplatin-based chemotherapy followed by surgery for malignant nonseminomatous germ cell tumor of mediastinum: one institution's experience. (19597926)
2009
17
Nonseminomatous germ cell tumor with seizure disorder and mental retardation. (20531999)
2009
18
Postchemotherapy laparoscopic retroperitoneal lymph node dissection in nonseminomatous germ-cell tumor. (19335332)
2009
19
Laparoscopic retroperitoneal lymph node dissection for nonseminomatous germ cell tumors: long-term oncologic outcomes. (18303540)
2008
20
Nonseminomatous germ cell tumor of the testis 9 years after a germ cell tumor of the pineal gland: case report and review of the literature. (18570724)
2008
21
Efficacy of modified retroperitoneal lymph node dissection for testicular nonseminomatous germ cell tumors]. (19079998)
2008
22
Metastatic malignant teratoma arising from mediastinal nonseminomatous germ cell tumor: a case report. (18472634)
2008
23
Isolated solitary bony metastasis of a nonseminomatous germ cell tumor. (17324327)
2007
24
Incidence of metastatic nonseminomatous germ cell tumor outside the boundaries of a modified postchemotherapy retroperitoneal lymph node dissection. (17906201)
2007
25
Does the presence of extranodal extension in pathological stage B1 nonseminomatous germ cell tumor necessitate adjuvant chemotherapy? (17296383)
2007
26
Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor. (18071871)
2007
27
Quality of life after laparoscopic and open retroperitoneal lymph node dissection in clinical Stage I nonseminomatous germ cell tumor: a comparison study. (16820195)
2006
28
Phase II study of oxaliplatin and gemcitabine salvage chemotherapy in patients with cisplatin-refractory nonseminomatous germ cell tumor. (16757095)
2006
29
Images in neuro-oncology: brain metastases and leptomeningeal dissemination of nonseminomatous germ cell tumor. (15933818)
2005
30
Intracaval and intracardiac metastatic nonseminomatous germ cell tumor: a rare cause of hemolytic anemia and thrombocytopenia. (12449733)
2002
31
Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor. (11407397)
2001
32
Drug dose delivery and treatment outcome relationship in standard bleomycin, etoposide and cisplatin combination chemotherapy in nonseminomatous germ cell tumor patients. (10613596)
1999
33
Compliance of clinical stage I nonseminomatous germ cell tumor patients with surveillance. (9720544)
1998
34
Is serum tumor marker half-life a guide to prognosis in metastatic nonseminomatous germ cell tumors? (9329598)
1997
35
Discordance between the site of primary nonseminomatous germ cell tumor of the testis and retroperitoneal metastatic disease secondary to anomalous venous drainage of the testis. (8632590)
1996
36
Recurrence of a nonseminomatous germ cell tumor 9 years postoperatively: is surveillance alone acceptable? (7853563)
1995
37
Mature teratoma metastatic from nonseminomatous germ cell tumor. (8311644)
1994
38
Laparoscopic retroperitoneal lymphadenectomy for high-risk stage 1 nonseminomatous germ cell tumor: report of four cases. (8165782)
1994
39
Surgical resection in patients with nonseminomatous germ cell tumor who fail to normalize serum tumor markers after chemotherapy. (7506856)
1994
40
The growing teratoma syndrome: a woman with nonseminomatous germ cell tumor of the ovary. (8314544)
1993
41
Cytogenetic analysis of the mature teratoma and the choriocarcinoma component of a testicular mixed nonseminomatous germ cell tumor. (1638483)
1992
42
Extragonadal and poor risk nonseminomatous germ cell tumors. Survival and prognostic features. (1848473)
1991
43
Serum tumor marker half-life during chemotherapy allows early prediction of complete response and survival in nonseminomatous germ cell tumors. (1697503)
1990
44
Observation after orchiectomy in clinical stage I nonseminomatous germ cell tumor of testis. Mayo Clinic experience. (2171316)
1990
45
The growing teratoma syndrome. A case of primary mediastinal nonseminomatous germ cell tumor treated with chemotherapy and radiotherapy. (1694474)
1990
46
A third option in the management of patients with clinical stage I nonseminomatous germ cell tumor? (2153195)
1990
47
Nonseminomatous germ cell tumor of the testicle: does extensive staging of the primary tumor predict the likelihood of metastatic disease? (3016346)
1986
48
Indolent nonseminomatous germ cell tumor of testis. Prolonged survival of patient with persistent metastatic disease. (3008399)
1986
49
Synchronous presentation of nonseminomatous germ cell tumor and renal cell carcinoma: a case report. (3022019)
1986
50
Primary nonseminomatous germ cell tumor of the prostate. (3944917)
1986

Variations for Nonseminomatous Germ Cell Tumor

About this section

Expression for genes affiliated with Nonseminomatous Germ Cell Tumor

About this section
Expression patterns in normal tissues for genes affiliated with Nonseminomatous Germ Cell Tumor

Search GEO for disease gene expression data for Nonseminomatous Germ Cell Tumor.

Pathways for genes affiliated with Nonseminomatous Germ Cell Tumor

About this section

Pathways related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5AFP, CGA
29.3CGB7, CGB
3
Show member pathways
9.1CGB5, CGA, CGB
4
Show member pathways
9.1CGB5, CGA, CGB

Compounds for genes affiliated with Nonseminomatous Germ Cell Tumor

About this section

Compounds related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
111-ketotestosterone449.8CGB5, CGA
2organon449.7CGA, CGB5
3trilostane44 1110.7CGB5, CGA
4estradiol benzoate449.7CGB5, CGA
5leuprolide44 61 28 1112.7CGA, CGB5
617-hydroxypregnenolone449.7CGB5, CGA
7dihydroprogesterone449.6CGA, CGB5
8cetrorelix44 28 1111.6CGB5, CGA
98-bromo-cyclic amp449.5CGA, CGB5
1022r-hydroxycholesterol44 2810.5CGB5, CGA
11vincristine44 50 1111.5AFP, CGB, CGB5
12leuprolide acetate449.4CGB5, CGA
13androstenedione44 2410.4CGB5, CGA, CGB
14diethylstilbestrol44 28 1111.4AFP, CGA, CGB5
15vinblastine44 50 1111.4CGB5, CGA, AFP
16buserelin44 28 1111.3CGB5, CGA
17leucovorin44 50 1111.3ERBB2, CGB5, CGB
18carboplatin44 50 1111.3CGA, ERBB2, AFP
19dmso449.2CGA, AFP, CGB5
20progestin449.1ERBB2, CGB5, CGA
21clomiphene citrate449.1CGB5, CGA, AFP, CGB
22ifosfamide44 1110.1CGB5, CGA, AFP, CGB
23mifepristone44 28 61 1112.1CGB, CGB5, CGA, AFP
24creatinine449.0CGA, AFP, CGB, CGB5
25paclitaxel44 50 1110.8APAF1, AFP, ERBB2, CGB5
26folate448.8CGB5, CGA, ERBB2, AFP
27epinephrine44 24 1110.8AFP, CGA, ERBB2, CGB5
28aspartate448.8CGA, ERBB2, AFP, APAF1
29paraffin448.8ERBB2, AFP, CGB5, CGA
30thyroxine44 249.8CGB, CGA, CGB7, AFP
31dexamethasone44 50 28 1111.7AFP, CGB5, ERBB2, APAF1
32ctp448.7CGA, CGB5, CGB7, CGB
33alanine448.5CGA, ERBB2, AFP, CGB
34aspirin44 50 28 2411.5CGA, CGB5, ERBB2
35cyclophosphamide44 50 1110.5CGB5, AFP, CGB, CGA, ERBB2
36estrogen448.4CGB5, CGA, ERBB2, AFP, CGB
37doxorubicin44 50 1110.4AFP, CGB5, ERBB2, APAF1, CGA
38h2o2448.3AFP, ERBB2, CGB5, APAF1, CGA
39steroid448.3APAF1, ERBB2, CGA, CGB5, AFP
40oestriol448.3CGB7, AFP, CGB, CGB5, CGA
41bleomycin44 119.3CGA, CGB, AFP, CGB7, CGB5
42estradiol44 24 1110.2CGB, CGB5, CGB7, CGA, AFP
43gnrh448.0ERBB2, CGB, CGA, CGB7, CGB5
44vegf448.0CGB5, ERBB2, AFP, CGB, APAF1, CGA
45methotrexate50 44 119.6AFP, CGB7, CGA, ERBB2, CGB, CGB5
46lactate447.6ERBB2, CGA, CGB7, CGB, CGB5, AFP
47progesterone44 28 61 24 1111.6CGB7, CGA, CGB, ERBB2, AFP, CGB5
48testosterone44 61 24 1110.6AFP, ERBB2, CGB, CGA, CGB7, CGB5
49etoposide44 50 61 1110.2CGB7, CGA, CGB, ERBB2, APAF1, AFP
50cisplatin44 50 61 1110.2APAF1, ERBB2, CGB, CGA, CGB5, AFP

GO Terms for genes affiliated with Nonseminomatous Germ Cell Tumor

About this section

Biological processes related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.6CGA, CGB

Molecular functions related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6CGA, CGB

Products for genes affiliated with Nonseminomatous Germ Cell Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Nonseminomatous Germ Cell Tumor

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet