NSGCT
MCID: NNS011
MIFTS: 26

Nonseminomatous Germ Cell Tumor (NSGCT) malady

Cancer diseases category

Summaries for Nonseminomatous Germ Cell Tumor

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Nonseminomatous germ cell tumors are cancerous tumors commonly found in the pineal gland in the brain, in the mediastinum, or in the abdomen. they originate from cells that were meant to form sex cells (i.e., sperm or eggs). they are often large and have a tendency to spread more quickly than the other type of germ cell tumor (i.e., seminoma type). possible early signs of this cancer include chest pain and breathing problems. last updated: 10/17/2013

MalaCards: Nonseminomatous Germ Cell Tumor, also known as non-seminomatous germ-cell tumors, is related to male germ cell tumor, somatic and choriocarcinoma. An important gene associated with Nonseminomatous Germ Cell Tumor is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Glycoprotein hormones and Insulin Processing. The compounds vincristine and 11-ketotestosterone have been mentioned in the context of this disorder. Affiliated tissues include brain and pineal.

Aliases & Classifications for Nonseminomatous Germ Cell Tumor

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42NIH Rare Diseases, 60UMLS
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Classifications:

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Global: Cancer diseases


Aliases & Descriptions:

nonseminomatous germ cell tumor 42 60
non-seminomatous germ-cell tumors 42
nsgct 42


Related Diseases for Nonseminomatous Germ Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Nonseminomatous Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1male germ cell tumor, somatic30.7CGA, AFP
2choriocarcinoma30.6AFP, CGB, CGA, CGB5, CGB7
3hyperthyroidism30.5CGA, CGB5, CGB
4seminoma30.5CGA, CGB, CGB7, CGB5, AFP
5endodermal sinus tumor30.4AFP
6gynecomastia30.4CGA, CGB5
7placental site trophoblastic tumor30.4CGB, CGA, CGB5
8testicular cancer30.4CGB, CGB5, CGA, AFP
9mediastinitis10.9
10mature teratoma10.7
11mixed germ cell cancer10.4
12primitive neuroectodermal tumor10.4
13prostatitis10.4
14malignant tumor of extragonadal non-seminomatous germ cell10.4
15mediastinal cancer10.4
16pericarditis10.4
17rhabdomyosarcoma10.4
18testis seminoma10.4
19extragonadal germ cell cancer10.3
20hemolytic anemia10.3
21leukemia10.3
22malignant teratoma10.3
23renal cell carcinoma10.3
24thrombocytopenia10.3
25pre-eclampsia10.0AFP
26spina bifida10.0AFP
27oligohydramnios10.0AFP
28omphalocele10.0AFP
29hypothyroidism10.0CGA
30thyroiditis10.0CGA
31prolactinoma10.0CGB, CGA
32anencephaly10.0CGA, AFP
33varicocele10.0CGA
34malignant mixed mullerian tumor10.0AFP, ERBB2
35edwards syndrome10.0AFP, CGA
36turner syndrome10.0CGA, CGB
37melanoma10.0APAF1, CGB
38tubular adenocarcinoma10.0ERBB2, AFP
39germ cell cancer10.0AFP, CGA
40stomach cancer10.0ERBB2, AFP
41extragonadal germ cell tumor10.0CGB5, AFP
42sarcoma10.0CGB5, CGB
43pituitary adenoma10.0CGB7, CGA
44leydig cell tumor10.0CGA, CGB5
45klinefelter's syndrome10.0CGB, CGA
46adenoma10.0CGB7, CGB, CGA
47trophoblastic neoplasm10.0CGB5, CGA
48cholangiocarcinoma10.0CGB, AFP, ERBB2
49ovarian cyst10.0CGA, CGB5
50gastric adenocarcinoma10.0ERBB2, CGB7, AFP

Graphical network of the top 20 diseases related to Nonseminomatous Germ Cell Tumor:



Diseases related to nonseminomatous germ cell tumor

Clinical Features for Nonseminomatous Germ Cell Tumor

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Drugs & Therapeutics for Nonseminomatous Germ Cell Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Nonseminomatous Germ Cell Tumor

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Anatomical Context for Nonseminomatous Germ Cell Tumor

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32MalaCards
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MalaCards organs/tissues related to Nonseminomatous Germ Cell Tumor:

32
Brain, Pineal

Animal Models for Nonseminomatous Germ Cell Tumor or affiliated genes

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Publications for Nonseminomatous Germ Cell Tumor

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Genetic Variations for Nonseminomatous Germ Cell Tumor

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Expression for genes affiliated with Nonseminomatous Germ Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nonseminomatous Germ Cell Tumor

Search GEO for disease gene expression data for Nonseminomatous Germ Cell Tumor.

Pathways for genes affiliated with Nonseminomatous Germ Cell Tumor

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53Reactome, 12EMD Millipore
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Pathways related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.6CGB, CGA
2
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9.6CGB, CGA
39.3CGB, CGB7

Compounds for genes affiliated with Nonseminomatous Germ Cell Tumor

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1vincristine44 49 1112.4AFP
211-ketotestosterone449.9CGA, CGB5
3organon449.8CGB5, CGA
4trilostane44 1110.8CGA, CGB5
5estradiol benzoate449.8CGB5, CGA
6leuprolide44 59 28 1112.8CGA, CGB5
717-hydroxypregnenolone449.8CGB5, CGA
8dihydroprogesterone449.7CGA, CGB5
9cetrorelix44 28 1111.7CGB5, CGA
108-bromo-cyclic amp449.7CGB5, CGA
1122r-hydroxycholesterol44 2810.6CGB5, CGA
12leuprolide acetate449.6CGA, CGB5
13anastrozole44 1110.6CGA, ERBB2
14buserelin44 28 1111.6CGB5, CGA
15androstenedione44 2410.5CGB, CGA, CGB5
16diethylstilbestrol44 28 1111.5CGB5, AFP, CGA
17vinblastine44 49 1111.4CGA, CGB5, AFP
18carboplatin44 49 1111.3ERBB2, CGA, AFP
19leucovorin44 49 1111.3ERBB2, CGB, CGB5
20progestin449.2CGA, ERBB2, CGB5
21lutein449.2CGB5, CGA
22clomiphene citrate449.2CGB, CGA, CGB5, AFP
23ifosfamide44 1110.1CGA, CGB, AFP, CGB5
24mifepristone44 59 28 1112.1AFP, CGB, CGA, CGB5
25dmso449.1CGB5, CGA, AFP
26creatinine449.0CGA, CGB, AFP, CGB5
27aspirin44 49 28 2411.9CGA, CGB5, ERBB2
28folate448.9CGB5, AFP, CGA, ERBB2
29epinephrine44 11 2410.8CGB5, CGA, AFP, ERBB2
30thyroxine44 249.8CGB7, CGB, AFP, CGA
31paraffin448.8CGB5, AFP, ERBB2, CGA
32aspartate448.8AFP, CGA, APAF1, ERBB2
33paclitaxel44 49 1110.8AFP, ERBB2, CGB5, APAF1
34ctp448.7CGB, CGB7, CGB5, CGA
35cyclophosphamide44 49 1110.5CGB, CGB5, CGA, AFP, ERBB2
36doxorubicin44 49 1110.4ERBB2, AFP, CGA, APAF1, CGB5
37oestriol448.3CGB5, AFP, CGB7, CGA, CGB
38h2o2448.3ERBB2, AFP, CGA, APAF1, CGB5
39bleomycin44 119.3CGB, CGB5, CGA, AFP, CGB7
40steroid448.3CGA, CGB5, APAF1, ERBB2, AFP
41dexamethasone44 49 28 1111.3APAF1, CGB5, AFP, ERBB2
42estradiol44 11 2410.3AFP, CGB7, CGB, CGB5, CGA
43gnrh448.1CGB, ERBB2, CGB7, CGB5, CGA
44vegf448.0AFP, CGA, APAF1, CGB5, CGB, ERBB2
45methotrexate44 49 119.7ERBB2, AFP, CGB5, CGB, CGA, CGB7
46lactate447.7ERBB2, CGA, CGB7, CGB, CGB5, AFP
47progesterone44 59 28 11 2411.7CGA, CGB5, CGB7, CGB, AFP, ERBB2
48testosterone44 59 11 2410.7CGB5, ERBB2, AFP, CGB, CGB7, CGA
49etoposide44 49 59 1110.2ERBB2, CGB, CGB7, AFP, APAF1, CGB5
50cisplatin44 49 59 1110.2ERBB2, CGB, APAF1, CGA, CGB5, CGB7

GO Terms for genes affiliated with Nonseminomatous Germ Cell Tumor

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16Gene Ontology
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Biological processes related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.6CGB, CGA

Products for genes affiliated with Nonseminomatous Germ Cell Tumor

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  • Antibodies
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Sources for Nonseminomatous Germ Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet