NSGCT
MCID: NNS011
MIFTS: 34

Nonseminomatous Germ Cell Tumor (NSGCT) malady

Cancer category

Summaries for Nonseminomatous Germ Cell Tumor

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Nonseminomatous germ cell tumors are cancerous tumors commonly found in the pineal gland in the brain, in the mediastinum, or in the abdomen. they originate from cells that were meant to form sex cells (i.e., sperm or eggs). they are often large and have a tendency to spread more quickly than the other type of germ cell tumor (i.e., seminoma type). possible early signs of this cancer include chest pain and breathing problems. last updated: 10/17/2013

MalaCards: Nonseminomatous Germ Cell Tumor, also known as non-seminomatous germ-cell tumors, is related to teratoma and germ cell cancer. An important gene associated with Nonseminomatous Germ Cell Tumor is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Glycoprotein hormones and Insulin Processing. The compounds vincristine and 11-ketotestosterone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and ovary.

Aliases & Classifications for Nonseminomatous Germ Cell Tumor

Sources:
43NIH Rare Diseases, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

nonseminomatous germ cell tumor 43 61
non-seminomatous germ-cell tumors 43
nsgct 43


Related Diseases for Nonseminomatous Germ Cell Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Nonseminomatous Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma31.3AFP, CGB, CGB7, CGB5, CGA
2germ cell cancer31.1AFP, CGA
3extragonadal germ cell tumor30.8CGB5, AFP
4male germ cell tumor, somatic30.8CGA, AFP
5gynecomastia30.4CGA, CGB5
6placental site trophoblastic tumor30.4CGB, CGA, CGB5
7testicular cancer30.4CGB, CGB5, CGA, AFP
8germ cell tumors11.2
9testicular germ cell tumor10.9
10testis seminoma10.7
11n syndrome10.7
12growing teratoma syndrome10.7
13malignant germ cell tumor10.6
14mixed germ cell tumor10.6
15extragonadal seminoma10.4
16t-cell leukemia10.3
17thrombocytopenia10.3
18mass syndrome10.3
19mental retardation10.3
20seizure disorder10.3
21pre-eclampsia10.0AFP
22endodermal sinus tumor10.0AFP
23spina bifida10.0AFP
24oligohydramnios10.0AFP
25omphalocele10.0AFP
26hypothyroidism10.0CGA
27thyroiditis10.0CGA
28prolactinoma10.0CGB, CGA
29anencephaly10.0CGA, AFP
30varicocele10.0CGA
31malignant mixed mullerian tumor10.0AFP, ERBB2
32edwards syndrome10.0AFP, CGA
33turner syndrome10.0CGA, CGB
34melanoma10.0APAF1, CGB
35tubular adenocarcinoma10.0ERBB2, AFP
36stomach cancer10.0ERBB2, AFP
37sarcoma10.0CGB5, CGB
38pituitary adenoma10.0CGB7, CGA
39leydig cell tumor10.0CGA, CGB5
40klinefelter's syndrome10.0CGB, CGA
41adenoma10.0CGB7, CGB, CGA
42trophoblastic neoplasm10.0CGB5, CGA
43cholangiocarcinoma10.0CGB, AFP, ERBB2
44ovarian cyst10.0CGA, CGB5
45gastric adenocarcinoma10.0ERBB2, CGB7, AFP
46oligospermia10.0CGA, CGB5
47precocious puberty10.0CGA, CGB5
48large cell carcinoma10.0CGB5, ERBB2
49prostate cancer10.0ERBB2, CGB, APAF1
50polycystic ovary syndrome10.0CGA, CGB5

Graphical network of the top 20 diseases related to Nonseminomatous Germ Cell Tumor:



Diseases related to nonseminomatous germ cell tumor

Clinical Features for Nonseminomatous Germ Cell Tumor

Drugs & Therapeutics for Nonseminomatous Germ Cell Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nonseminomatous Germ Cell Tumor

Drug clinical trials:

Search ClinicalTrials for Nonseminomatous Germ Cell Tumor

Search NIH Clinical Center for Nonseminomatous Germ Cell Tumor

Search CenterWatch for Nonseminomatous Germ Cell Tumor

Genetic Tests for Nonseminomatous Germ Cell Tumor

Anatomical Context for Nonseminomatous Germ Cell Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Nonseminomatous Germ Cell Tumor:

33
Lymph node, Brain, Ovary, Prostate, Testis, T cells, B cells, Pineal, Testis germ

Animal Models for Nonseminomatous Germ Cell Tumor or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Nonseminomatous Germ Cell Tumor

Sources:
51PubMed
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Articles related to Nonseminomatous Germ Cell Tumor:

(show top 50)    (show all 164)
idTitleAuthorsYear
1
The role of lymph vessel density and lymphangiogenesis in metastatic tumor spread of nonseminomatous testicular germ cell tumors. (23141777)
2014
2
Anatomical retroperitoneoscopic retroperitoneal lymph node dissection for clinical stage I nonseminomatous germ cell tumors: Initial operative experience. (24369147)
2014
3
Risk factors for relapse in patients with clinical stage I testicular nonseminomatous germ cell tumors. (23400963)
2013
4
Testicular hilum and vascular invasion predict advanced clinical stage in nonseminomatous germ cell tumors. (23238629)
2013
5
The role of residual tumor resection in the management of nonseminomatous germ cell cancer of testicular origin. (22383152)
2012
6
What is the role of enlarged lymph node resection alone in patients with nonseminomatous germ cell tumor who had stage II or III disease? (22682983)
2012
7
Genomic characterization of testis cancer: association of alterations with outcome of clinical stage 1 mixed germ cell nonseminomatous germ cell tumor of the testis. (22503760)
2012
8
Words of wisdom. Re: management of disseminated nonseminomatous germ cell tumors with risk-based chemotherapy followed by response-guided postchemotherapy surgery. (21524725)
2011
9
Stage I nonseminomatous germ cell tumor of the testis: more questions than answers? (21570606)
2011
10
Trends of retroperitoneal lymphadenectomy use in patients with nonseminomatous germ cell tumor of the testis: a population-based study. (21509630)
2011
11
Management of low-stage nonseminomatous germ cell tumors of testis: SIU/ICUD Consensus Meeting on Germ Cell Tumors (GCT), Shanghai 2009. (21986224)
2011
12
Management of good-risk metastatic nonseminomatous germ cell tumors of the testis: current concepts and controversies. (20535293)
2010
13
Laparoscopic retroperitoneal lymph node dissection with therapeutic intent in men with clinical stage I nonseminomatous germ cell tumors. (20879859)
2010
14
Nonseminomatous germ cell tumor of the testes metastatic to the corpus cavernosum of the penis. (19931126)
2010
15
Thoracic metastasectomy for nonseminomatous germ cell tumors. (20502259)
2010
16
Outcome following resection for patients with primary mediastinal nonseminomatous germ-cell tumors and rising serum tumor markers post-chemotherapy. (19889611)
2010
17
Long-term follow-up of Cisplatin combination chemotherapy in patients with disseminated nonseminomatous germ cell tumors: is a postchemotherapy retroperitoneal lymph node dissection needed after complete remission? (20026808)
2010
18
Nonseminomatous germ cell tumor with seizure disorder and mental retardation. (20531999)
2009
19
Laparoscopic retroperitoneal lymph node dissection for nonseminomatous germ cell tumors: long-term oncologic outcomes. (18303540)
2008
20
Nonseminomatous germ cell tumor of the testis 9 years after a germ cell tumor of the pineal gland: case report and review of the literature. (18570724)
2008
21
Burkitt's leukemia after treatment of primary mediastinal nonseminomatous germ cell tumor. (18445847)
2008
22
Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors. (18622385)
2008
23
Incidence of metastatic nonseminomatous germ cell tumor outside the boundaries of a modified postchemotherapy retroperitoneal lymph node dissection. (17906201)
2007
24
Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor. (18071871)
2007
25
Significance of primary tumor size and preorchiectomy serum tumor marker level in predicting pathologic stage at retroperitoneal lymph node dissection in clinical Stage A nonseminomatous germ cell tumors. (17382165)
2007
26
Enlarging residual mass after treatment of a nonseminomatous germ cell tumor: growing teratoma syndrome or cancer recurrence? (17906212)
2007
27
Successful chemotherapy for advanced nonseminomatous germ-cell tumor in a patient undergoing chronic hemodialysis. (17401020)
2007
28
Recurrence in nonseminomatous germ cell testis tumor patients with no viable tumor at postchemotherapy retroperitoneal lymph node dissection. (18158041)
2007
29
Nonseminomatous germ cell tumor after chemotherapy with residual mass invading the spine: part 2. (16977689)
2006
30
Is high-dose chemotherapy after primary chemotherapy a therapeutic option for patients with primary mediastinal nonseminomatous germ cell tumor? (17084372)
2006
31
Nonseminomatous germ cell tumor after chemotherapy with residual mass invading the spine. (16626860)
2006
32
Images in neuro-oncology: brain metastases and leptomeningeal dissemination of nonseminomatous germ cell tumor. (15933818)
2005
33
Early predicted time to normalization of tumor markers predicts outcome in poor-prognosis nonseminomatous germ cell tumors. (15302906)
2004
34
Risk-adapted treatment for patients with clinical stage I nonseminomatous germ cell tumor of the testis. (14751368)
2004
35
Prostate carcinoma presenting as multiple pulmonary nodules in an asymptomatic patient with a history of testicular nonseminomatous germ cell tumor. (14550460)
2003
36
Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors. (11764380)
2001
37
Unusual presentations of germ cell tumors. Case 3. Nonseminomatous extragonadal germ cell tumor presenting with pulmonary emboli. (11157046)
2001
38
Risk adapted management with adjuvant chemotherapy in patients with high risk clinical stage i nonseminomatous germ cell tumor. (10799182)
2000
39
Mature teratoma identified after postchemotherapy surgery in patients with disseminated nonseminomatous testicular germ cell tumors: a plea for an aggressive surgical approach. (9529027)
1998
40
Importance of a new tumor marker TRA-1-60 in the follow-up of patients with clinical stage I nonseminomatous testicular germ cell tumors. (9181232)
1997
41
Residual pulmonary masses after chemotherapy for metastatic nonseminomatous germ cell tumor. Prediction of histology. ReHiT Study Group. (9010108)
1997
42
Discordance between the site of primary nonseminomatous germ cell tumor of the testis and retroperitoneal metastatic disease secondary to anomalous venous drainage of the testis. (8632590)
1996
43
Does serum tumor marker half-life complement pretreatment risk stratification in metastatic nonseminomatous germ cell tumors? (9816334)
1996
44
Laparoscopic retroperitoneal lymphadenectomy for high-risk stage 1 nonseminomatous germ cell tumor: report of four cases. (8165782)
1994
45
Primary skeletal metastasis of a nonseminomatous germ cell tumor. (8154086)
1994
46
Cytogenetic analysis of the mature teratoma and the choriocarcinoma component of a testicular mixed nonseminomatous germ cell tumor. (1638483)
1992
47
Surgical resection of solitary metastases after chemotherapy in patients with nonseminomatous germ cell tumors and elevated serum tumor markers. (1382832)
1992
48
A third option in the management of patients with clinical stage I nonseminomatous germ cell tumor? (2153195)
1990
49
Disease relapse in patients with stage I nonseminomatous germ cell tumor of the testis on active surveillance. (2459319)
1988
50
Synchronous presentation of nonseminomatous germ cell tumor and renal cell carcinoma: a case report. (3022019)
1986

Genetic Variations for Nonseminomatous Germ Cell Tumor

Expression for genes affiliated with Nonseminomatous Germ Cell Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nonseminomatous Germ Cell Tumor

Search GEO for disease gene expression data for Nonseminomatous Germ Cell Tumor.

Pathways for genes affiliated with Nonseminomatous Germ Cell Tumor

Sources:
54Reactome, 12EMD Millipore
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Pathways related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6CGB, CGA
2
Hide members
9.6CGB, CGA
39.3CGB, CGB7

Compounds for genes affiliated with Nonseminomatous Germ Cell Tumor

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1vincristine45 50 1112.4AFP
211-ketotestosterone459.9CGA, CGB5
3organon459.8CGB5, CGA
4trilostane45 1110.8CGA, CGB5
5estradiol benzoate459.8CGB5, CGA
6leuprolide45 60 29 1112.8CGA, CGB5
717-hydroxypregnenolone459.8CGB5, CGA
8dihydroprogesterone459.7CGA, CGB5
9cetrorelix45 29 1111.7CGB5, CGA
108-bromo-cyclic amp459.7CGB5, CGA
1122r-hydroxycholesterol45 2910.6CGB5, CGA
12leuprolide acetate459.6CGA, CGB5
13anastrozole45 1110.6CGA, ERBB2
14buserelin45 29 1111.6CGB5, CGA
15androstenedione45 2410.5CGB, CGA, CGB5
16diethylstilbestrol45 29 1111.5CGB5, AFP, CGA
17vinblastine45 50 1111.4CGA, CGB5, AFP
18carboplatin45 50 1111.3ERBB2, CGA, AFP
19leucovorin45 50 1111.3ERBB2, CGB, CGB5
20progestin459.2CGA, ERBB2, CGB5
21lutein459.2CGB5, CGA
22clomiphene citrate459.2CGB, CGA, CGB5, AFP
23ifosfamide45 1110.1CGA, CGB, AFP, CGB5
24mifepristone45 60 29 1112.1AFP, CGB, CGA, CGB5
25dmso459.1CGB5, CGA, AFP
26creatinine459.0CGA, CGB, AFP, CGB5
27aspirin45 50 29 2411.9CGA, CGB5, ERBB2
28folate458.9CGB5, AFP, CGA, ERBB2
29epinephrine45 11 2410.8CGB5, CGA, AFP, ERBB2
30thyroxine45 249.8CGB7, CGB, AFP, CGA
31paraffin458.8CGB5, AFP, ERBB2, CGA
32aspartate458.8AFP, CGA, APAF1, ERBB2
33paclitaxel45 50 1110.8AFP, ERBB2, CGB5, APAF1
34ctp458.7CGB, CGB7, CGB5, CGA
35cyclophosphamide45 50 1110.5CGB, CGB5, CGA, AFP, ERBB2
36doxorubicin45 50 1110.4ERBB2, AFP, CGA, APAF1, CGB5
37oestriol458.3CGB5, AFP, CGB7, CGA, CGB
38h2o2458.3ERBB2, AFP, CGA, APAF1, CGB5
39bleomycin45 119.3CGB, CGB5, CGA, AFP, CGB7
40steroid458.3CGA, CGB5, APAF1, ERBB2, AFP
41dexamethasone45 50 29 1111.3APAF1, CGB5, AFP, ERBB2
42estradiol45 11 2410.3AFP, CGB7, CGB, CGB5, CGA
43gnrh458.1CGB, ERBB2, CGB7, CGB5, CGA
44vegf458.0AFP, CGA, APAF1, CGB5, CGB, ERBB2
45methotrexate45 50 119.7ERBB2, AFP, CGB5, CGB, CGA, CGB7
46lactate457.7ERBB2, CGA, CGB7, CGB, CGB5, AFP
47progesterone45 60 29 11 2411.7CGA, CGB5, CGB7, CGB, AFP, ERBB2
48testosterone45 60 11 2410.7CGB5, ERBB2, AFP, CGB, CGB7, CGA
49etoposide45 50 60 1110.2ERBB2, CGB, CGB7, AFP, APAF1, CGB5
50cisplatin45 50 60 1110.2ERBB2, CGB, APAF1, CGA, CGB5, CGB7

GO Terms for genes affiliated with Nonseminomatous Germ Cell Tumor

Sources:
16Gene Ontology
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Biological processes related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.6CGB, CGA

Products for genes affiliated with Nonseminomatous Germ Cell Tumor

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Sources for Nonseminomatous Germ Cell Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet