NSGCT
MCID: NNS011
MIFTS: 41

Nonseminomatous Germ Cell Tumor (NSGCT) malady

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Summaries for Nonseminomatous Germ Cell Tumor

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Nonseminomatous germ cell tumors are cancerous tumors commonly found in the pineal gland in the brain, in the mediastinum, or in the abdomen. they originate from cells that were meant to form sex cells (i.e., sperm or eggs). they are often large and have a tendency to spread more quickly than the other type of germ cell tumor (i.e., seminoma type). possible early signs of this cancer include chest pain and breathing problems. last updated: 10/17/2013

MalaCards: Nonseminomatous Germ Cell Tumor, also known as non-seminomatous germ-cell tumors, is related to teratoma and male germ cell tumor, somatic. An important gene associated with Nonseminomatous Germ Cell Tumor is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Glucocorticoid receptor regulatory network and Selected targets of Oct 3 4. The compounds 11-ketotestosterone and organon have been mentioned in the context of this disorder. Affiliated tissues include testis, brain and pineal, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Aliases & Classifications for Nonseminomatous Germ Cell Tumor

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43NIH Rare Diseases, 62UMLS
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Classifications:

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Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

nonseminomatous germ cell tumor 43 62
non-seminomatous germ-cell tumors 43
nsgct 43


Related Diseases for Nonseminomatous Germ Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Nonseminomatous Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma31.2CGA, CGB7, CGB5, AFP, CGB
2male germ cell tumor, somatic30.9AFP, CGA
3endodermal sinus tumor30.7AFP
4hyperthyroidism30.6CGB, CGA, CGB5
5choriocarcinoma30.6AFP, CGA, CGB7, CGB, CGB5
6germ cell cancer30.5CGA, AFP
7placental site trophoblastic tumor30.5CGA, CGB, CGB5
8seminoma30.4CGB, CGA, AFP, CGB5, CGB7
9testicular cancer30.4CGB5, CGB, AFP, CGA
10germ cell tumors11.4
11mediastinitis10.9
12mature teratoma10.6
13growing teratoma syndrome10.6
14primitive neuroectodermal tumor10.5
15prostatitis10.5
16malignant tumor of extragonadal non-seminomatous germ cell10.4
17rhabdomyosarcoma10.4
18testicular germ cell tumor10.4
19hemolytic anemia10.3
20leukemia10.3
21malignant teratoma10.3
22renal cell carcinoma10.3
23thrombocytopenia10.3
24mental retardation10.3
25seizure disorder10.3
26oligohydramnios10.1AFP
27extragonadal germ cell tumor10.1CGB5, AFP
28malignant mixed mullerian tumor10.0ERBB2, AFP
29tubular adenocarcinoma10.0ERBB2, AFP
30large cell carcinoma10.0CGB5, ERBB2
31bladder carcinoma10.0ERBB2, CGB
32anencephaly10.0CGA, AFP
33cryptococcosis10.0CGB5, CGB7, CGB
34edwards syndrome10.0CGA, AFP
35turner syndrome10.0CGB, CGA
36leydig cell tumor10.0CGA, CGB5
37factor v leiden thrombophilia10.0CGB, CGB5, CGB7
38gastric adenocarcinoma10.0CGB7, ERBB2, AFP
39trophoblastic neoplasm10.0CGA, CGB5
40ovarian cyst10.0CGB5, CGA
41ovarian hyperstimulation syndrome10.0CGB5, CGA
42klinefelter's syndrome10.0CGB, CGA
43cholangiocarcinoma10.0ERBB2, AFP, CGB
44gynecomastia10.0CGA, CGB5
45oligospermia10.0CGB5, CGA
46prolactinoma10.0CGA, CGB
47precocious puberty10.0CGB5, CGA
48kallmann syndrome10.0CGB5, CGA
49cryptorchidism10.0CGB5, CGA
50hyperandrogenism10.0CGA, CGB5

Graphical network of the top 20 diseases related to Nonseminomatous Germ Cell Tumor:



Diseases related to nonseminomatous germ cell tumor

Symptoms for Nonseminomatous Germ Cell Tumor

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Drugs & Therapeutics for Nonseminomatous Germ Cell Tumor

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Nonseminomatous Germ Cell Tumor

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Genetic Tests for Nonseminomatous Germ Cell Tumor

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Anatomical Context for Nonseminomatous Germ Cell Tumor

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33MalaCards
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MalaCards organs/tissues related to Nonseminomatous Germ Cell Tumor:

33
Testis, Brain, Pineal, Lymph node, Testes, Prostate, Bone, Ovary

Animal Models for Nonseminomatous Germ Cell Tumor or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Nonseminomatous Germ Cell Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5CGA, ERBB2, APAF1, AFP
2MP:00053798.2CGA, ERBB2, APAF1, AFP

Publications for Nonseminomatous Germ Cell Tumor

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52PubMed
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Articles related to Nonseminomatous Germ Cell Tumor:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Treatment outcome of patients with extragonadal nonseminomatous germ cell tumors: the Saitama Cancer Center experience. (22763659)
2013
2
Nonseminomatous germ cell tumor of testis and interrupted treatment. (24133836)
2013
3
Salvage therapy with high-dose chemotherapy and peripheral blood stem cell transplant in patients with primary mediastinal nonseminomatous germ cell tumors. (22892555)
2013
4
Correlation between retroperitoneal lymph node size and presence of metastases in nonseminomatous germ cell tumors. (22180527)
2012
5
Extraperitoneal laparoscopic retroperitoneal lymph node dissection for early-stage testicular nonseminomatous germ cell tumors: initial experience. (22524310)
2012
6
Words of wisdom. Re: management of disseminated nonseminomatous germ cell tumors with risk-based chemotherapy followed by response-guided postchemotherapy surgery. (21524725)
2011
7
Stage I nonseminomatous germ cell tumor of the testis: more questions than answers? (21570606)
2011
8
Management of residual mass in nonseminomatous germ cell tumors following chemotherapy. (21969846)
2011
9
Secondary malignancies among nonseminomatous germ cell tumor cancer survivors. (21412759)
2011
10
Influence of suboptimal treatment in patients with mediastinal primary nonseminomatous germ cell tumors. (20185939)
2010
11
Management of good-risk metastatic nonseminomatous germ cell tumors of the testis: current concepts and controversies. (20535293)
2010
12
Laparoscopic retroperitoneal lymph node dissection with therapeutic intent in men with clinical stage I nonseminomatous germ cell tumors. (20879859)
2010
13
Nonseminomatous germ cell tumor of the testes metastatic to the corpus cavernosum of the penis. (19931126)
2010
14
Thoracic metastasectomy for nonseminomatous germ cell tumors. (20502259)
2010
15
High-risk clinical stage I nonseminomatous germ cell tumors: the case for chemotherapy. (19636566)
2009
16
Cisplatin-based chemotherapy followed by surgery for malignant nonseminomatous germ cell tumor of mediastinum: one institution's experience. (19597926)
2009
17
Nonseminomatous germ cell tumor with seizure disorder and mental retardation. (20531999)
2009
18
Postchemotherapy laparoscopic retroperitoneal lymph node dissection in nonseminomatous germ-cell tumor. (19335332)
2009
19
Laparoscopic retroperitoneal lymph node dissection for nonseminomatous germ cell tumors: long-term oncologic outcomes. (18303540)
2008
20
Nonseminomatous germ cell tumor of the testis 9 years after a germ cell tumor of the pineal gland: case report and review of the literature. (18570724)
2008
21
Efficacy of modified retroperitoneal lymph node dissection for testicular nonseminomatous germ cell tumors]. (19079998)
2008
22
Metastatic malignant teratoma arising from mediastinal nonseminomatous germ cell tumor: a case report. (18472634)
2008
23
Isolated solitary bony metastasis of a nonseminomatous germ cell tumor. (17324327)
2007
24
Incidence of metastatic nonseminomatous germ cell tumor outside the boundaries of a modified postchemotherapy retroperitoneal lymph node dissection. (17906201)
2007
25
Does the presence of extranodal extension in pathological stage B1 nonseminomatous germ cell tumor necessitate adjuvant chemotherapy? (17296383)
2007
26
Successful 2-year-long remission following repeated salvage surgery in a patient with chemotherapy-resistant metastatic nonseminomatous germ cell tumor. (18071871)
2007
27
Quality of life after laparoscopic and open retroperitoneal lymph node dissection in clinical Stage I nonseminomatous germ cell tumor: a comparison study. (16820195)
2006
28
Phase II study of oxaliplatin and gemcitabine salvage chemotherapy in patients with cisplatin-refractory nonseminomatous germ cell tumor. (16757095)
2006
29
Images in neuro-oncology: brain metastases and leptomeningeal dissemination of nonseminomatous germ cell tumor. (15933818)
2005
30
Intracaval and intracardiac metastatic nonseminomatous germ cell tumor: a rare cause of hemolytic anemia and thrombocytopenia. (12449733)
2002
31
Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor. (11407397)
2001
32
Drug dose delivery and treatment outcome relationship in standard bleomycin, etoposide and cisplatin combination chemotherapy in nonseminomatous germ cell tumor patients. (10613596)
1999
33
Compliance of clinical stage I nonseminomatous germ cell tumor patients with surveillance. (9720544)
1998
34
Is serum tumor marker half-life a guide to prognosis in metastatic nonseminomatous germ cell tumors? (9329598)
1997
35
Discordance between the site of primary nonseminomatous germ cell tumor of the testis and retroperitoneal metastatic disease secondary to anomalous venous drainage of the testis. (8632590)
1996
36
Recurrence of a nonseminomatous germ cell tumor 9 years postoperatively: is surveillance alone acceptable? (7853563)
1995
37
Mature teratoma metastatic from nonseminomatous germ cell tumor. (8311644)
1994
38
Laparoscopic retroperitoneal lymphadenectomy for high-risk stage 1 nonseminomatous germ cell tumor: report of four cases. (8165782)
1994
39
Surgical resection in patients with nonseminomatous germ cell tumor who fail to normalize serum tumor markers after chemotherapy. (7506856)
1994
40
The growing teratoma syndrome: a woman with nonseminomatous germ cell tumor of the ovary. (8314544)
1993
41
Cytogenetic analysis of the mature teratoma and the choriocarcinoma component of a testicular mixed nonseminomatous germ cell tumor. (1638483)
1992
42
Extragonadal and poor risk nonseminomatous germ cell tumors. Survival and prognostic features. (1848473)
1991
43
Serum tumor marker half-life during chemotherapy allows early prediction of complete response and survival in nonseminomatous germ cell tumors. (1697503)
1990
44
Observation after orchiectomy in clinical stage I nonseminomatous germ cell tumor of testis. Mayo Clinic experience. (2171316)
1990
45
The growing teratoma syndrome. A case of primary mediastinal nonseminomatous germ cell tumor treated with chemotherapy and radiotherapy. (1694474)
1990
46
A third option in the management of patients with clinical stage I nonseminomatous germ cell tumor? (2153195)
1990
47
Nonseminomatous germ cell tumor of the testicle: does extensive staging of the primary tumor predict the likelihood of metastatic disease? (3016346)
1986
48
Indolent nonseminomatous germ cell tumor of testis. Prolonged survival of patient with persistent metastatic disease. (3008399)
1986
49
Synchronous presentation of nonseminomatous germ cell tumor and renal cell carcinoma: a case report. (3022019)
1986
50
Primary nonseminomatous germ cell tumor of the prostate. (3944917)
1986

Variations for Nonseminomatous Germ Cell Tumor

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Nonseminomatous Germ Cell Tumor:

1
id Gene Name Type Significance SNP ID Assembly Location
1BRAFNM_004333.4(BRAF): c.1799T> A (p.Val600Glu)single nucleotide variantPathogenicrs113488022GRCh37Chr 7, 140453136: 140453136

Expression for genes affiliated with Nonseminomatous Germ Cell Tumor

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nonseminomatous Germ Cell Tumor

Search GEO for disease gene expression data for Nonseminomatous Germ Cell Tumor.

Pathways for genes affiliated with Nonseminomatous Germ Cell Tumor

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50PathCards, 38NCBI BioSystems Database, 12EMD Millipore, 55Reactome, 30KEGG
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Pathways related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CGA, AFP
29.3CGB7, CGB
3
Show member pathways
9.1CGA, CGB, CGB5
4
Show member pathways
9.1CGB5, CGA, CGB

Compounds for genes affiliated with Nonseminomatous Germ Cell Tumor

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45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 24HMDB
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Compounds related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
111-ketotestosterone459.8CGB5, CGA
2organon459.7CGA, CGB5
3trilostane45 1110.7CGB5, CGA
4estradiol benzoate459.7CGB5, CGA
5leuprolide45 61 29 1112.7CGA, CGB5
617-hydroxypregnenolone459.7CGB5, CGA
7dihydroprogesterone459.6CGA, CGB5
8cetrorelix45 29 1111.6CGB5, CGA
98-bromo-cyclic amp459.5CGA, CGB5
1022r-hydroxycholesterol45 2910.5CGB5, CGA
11vincristine45 51 1111.5AFP, CGB, CGB5
12leuprolide acetate459.4CGB5, CGA
13androstenedione45 2410.4CGB5, CGA, CGB
14diethylstilbestrol45 29 1111.4AFP, CGA, CGB5
15vinblastine45 51 1111.4CGB5, CGA, AFP
16buserelin45 29 1111.3CGB5, CGA
17leucovorin45 51 1111.3ERBB2, CGB5, CGB
18carboplatin45 51 1111.3CGA, ERBB2, AFP
19dmso459.2CGA, AFP, CGB5
20progestin459.1ERBB2, CGB5, CGA
21clomiphene citrate459.1CGB5, CGA, AFP, CGB
22ifosfamide45 1110.1CGB5, CGA, AFP, CGB
23mifepristone45 29 61 1112.1CGB, CGB5, CGA, AFP
24creatinine459.0CGA, AFP, CGB, CGB5
25paclitaxel45 51 1110.8APAF1, AFP, ERBB2, CGB5
26folate458.8CGB5, CGA, ERBB2, AFP
27epinephrine45 24 1110.8AFP, CGA, ERBB2, CGB5
28aspartate458.8CGA, ERBB2, AFP, APAF1
29paraffin458.8ERBB2, AFP, CGB5, CGA
30thyroxine45 249.8CGB, CGA, CGB7, AFP
31dexamethasone45 51 29 1111.7AFP, CGB5, ERBB2, APAF1
32ctp458.7CGA, CGB5, CGB7, CGB
33alanine458.5CGA, ERBB2, AFP, CGB
34aspirin45 51 29 2411.5CGA, CGB5, ERBB2
35cyclophosphamide45 51 1110.5CGB5, AFP, CGB, CGA, ERBB2
36estrogen458.4CGB5, CGA, ERBB2, AFP, CGB
37doxorubicin45 51 1110.4AFP, CGB5, ERBB2, APAF1, CGA
38h2o2458.3AFP, ERBB2, CGB5, APAF1, CGA
39steroid458.3APAF1, ERBB2, CGA, CGB5, AFP
40oestriol458.3CGB7, AFP, CGB, CGB5, CGA
41bleomycin45 119.3CGA, CGB, AFP, CGB7, CGB5
42estradiol45 24 1110.2CGB, CGB5, CGB7, CGA, AFP
43gnrh458.0ERBB2, CGB, CGA, CGB7, CGB5
44vegf458.0CGB5, ERBB2, AFP, CGB, APAF1, CGA
45methotrexate51 45 119.6AFP, CGB7, CGA, ERBB2, CGB, CGB5
46lactate457.6ERBB2, CGA, CGB7, CGB, CGB5, AFP
47progesterone45 29 61 24 1111.6CGB7, CGA, CGB, ERBB2, AFP, CGB5
48testosterone45 61 24 1110.6AFP, ERBB2, CGB, CGA, CGB7, CGB5
49etoposide45 51 61 1110.2CGB7, CGA, CGB, ERBB2, APAF1, AFP
50cisplatin45 51 61 1110.2APAF1, ERBB2, CGB, CGA, CGB5, AFP

GO Terms for genes affiliated with Nonseminomatous Germ Cell Tumor

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16Gene Ontology
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Biological processes related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone processingGO:0164869.6CGA, CGB

Molecular functions related to Nonseminomatous Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6CGA, CGB

Products for genes affiliated with Nonseminomatous Germ Cell Tumor

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Sources for Nonseminomatous Germ Cell Tumor

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet