Nonspecific Interstitial Pneumonia malady

Disease Ontology: An idiopathic interstitial pneumonia that occurs mainly in women, people who do not smoke, and people younger than 50 years with no known cause or risk factors. lung biopsies may show predominantly interstitial inflammation or fibrosis or a combination of inflammation and fibrosis. a dry cough and shortness of breath develop over 6 to 18 months. low-grade fever and a feeling of illness (malaise) may occur.⁶

MalaCards: Nonspecific Interstitial Pneumonia, also known as nonspecific interstitial pneumonia (disorder), is related to usual interstitial pneumonia and idiopathic pulmonary fibrosis. An important gene associated with Nonspecific Interstitial Pneumonia is FOXF1 (forkhead box F1), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and NFAT Signaling and Lymphocyte Interactions. The compounds sp 600125 and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia: Non-specific interstitial pneumonia (NSIP) is a form of idiopathic interstitial pneumonia.⁴⁴ more...

Aliases & Descriptions:

nonspecific interstitial pneumonia 6 8 43 nonspecific interstitial pneumonia (disorder) 6

nsip 6

Diseases related to nonspecific interstitial pneumonia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 449)

id	Related Disease	Score	Top Affiliating Genes
1	usual interstitial pneumonia	29.5	SFTPC, SERPINH1, FGF2, IL13, IL8, CCL2
2	idiopathic pulmonary fibrosis	28.5	FGF2, IL8, IFNG, TGFB1
3	pneumonia	26.9	SFTPC, SERPINH1, FOXF1, FGF2, IL13, IL18
4	vascular disease	25.7	FGF2, IL18, IL6, IL8, CCL2, IFNG
5	pulmonary fibrosis	25.4	SFTPC, SERPINH1, FGF2, IL13, IL18, IL6
6	fibrosis	24.9	SFTPC, SERPINH1, FGF2, IL13, IL18, IL6
7	intermediate uveitis	13.5	CCR4, CXCR3
8	contact dermatitis	13.3	CCR4, CXCR3
9	cervical incompetence	13.2	SERPINH1, IL6
10	viral meningitis	13.1	IL6, CXCR3
11	stevens-johnson syndrome	13.1	IL13, HSPG2, CXCR3
12	erythema multiforme	13.1	CCL2, HSPG2, CXCR3
13	adult-onset still's disease	13.1	IL18, IL6
14	fibromatosis, gingival	13.0	SERPINH1, TGFB1
15	periventricular leukomalacia	13.0	SERPINH1, IL18, IL6
16	mixed connective tissue disease	12.9	SERPINH1, IL6, HSPG2
17	spermatocele	12.9	IL6, IL8
18	vernal keratoconjunctivitis	12.9	IL13, IL8, CXCR3
19	radiculopathy	12.9	IL13, IL6, CXCR3
20	melioidosis	12.9	IL18, IL6, CXCR3
21	bagassosis	12.9	IL6, IL8
22	pulmonary alveolar proteinosis	12.9	SFTPC, IL8, CCL2
23	extrinsic allergic alveolitis	12.9	IL8, CCL2, CXCR3
24	allergic rhinitis	12.8	IL13, IL18, IL8
25	skin melanoma	12.8	FGF2, IL8, CCR4
26	hip dysplasia	12.8	IL6, TGFB1
27	malt lymphoma	12.8	IL6, HSPG2, CXCR3
28	behcet's disease	12.8	IL18, IL8, HSPG2
29	ureteral disease	12.8	CCL2, TGFB1
30	adult respiratory distress syndrome	12.8	SFTPC, IL6, IL8
31	acute interstitial pneumonia	12.8	SFTPC, IL13, CCR4, HSPG2, CXCR3
32	funisitis	12.8	IL6, IL8
33	newborn respiratory distress syndrome	12.8	SFTPC, IL6, IL8
34	common wart	12.7	IL6, IL8
35	keloids	12.7	SERPINH1, FGF2, TGFB1
36	pleural tuberculosis	12.7	IL18, IFNG
37	peripheral arterial occlusive disease	12.7	IL18, IL6, CCL2
38	mesangial proliferative glomerulonephritis	12.7	FGF2, IL6, CCL2
39	arterial occlusive disease	12.7	IL18, IL6, CCL2
40	cutaneous t cell lymphoma	12.7	CCR4, IFNG, CXCR3
41	diabetic macular edema	12.7	FGF2, IL6, CCL2
42	t-cell large granular lymphocyte leukemia	12.6	IL18, IL6, IL8
43	pericarditis	12.6	IL6, IL8, HSPG2
44	carpal tunnel syndrome	12.6	FGF2, IL6, CCL2
45	pancreatic diseases	12.6	IL6, IL8, CXCL5
46	whiplash	12.6	IL6, IFNG
47	relapsing-remitting multiple sclerosis	12.6	IL18, IFNG, CXCR3
48	large granular lymphocyte leukemia	12.6	IL18, IL6, IL8
49	periapical granuloma	12.6	CCL2, IFNG, CXCR3
50	myxoid liposarcoma of the ovary	12.6	IL6, IL8, CCL2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to nonspecific interstitial pneumonia:

²²

MGI Mouse Phenotypes related to nonspecific interstitial pneumonia:

²⁵ (show all 14)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.1	CCR4, FOXF1, SFTPC
2	hematopoietic system phenotype	MP:0005397	9.6	FGF2, CCR4, SLC7A1
3	other phenotype	MP:0005395	9.3	CXCR3, HSPG2, IL13, SERPINH1
4	immune system phenotype	MP:0005387	8.5	IL6, IFNG, HSPG2, SHH, SLC7A2
5	growth/size phenotype	MP:0005378	7.8	SLC7A1, SHH, HSPG2, IL6, IL18, IL13
6	tumorigenesis	MP:0002006	7.0	CXCR3, TGFB1, SHH, IFNG, CCL2, IL6
7	digestive/alimentary phenotype	MP:0005381	6.9	TGFB1, SHH, HSPG2, IFNG, CCL2, IL6
8	reproductive system phenotype	MP:0005389	6.8	SHH, IFNG, CCL2, IL6, IL13, FGF2
9	muscle phenotype	MP:0005369	6.7	TGFB1, SHH, HSPG2, IFNG, CCL2, IL6
10	vision/eye phenotype	MP:0005391	6.6	TGFB1, SHH, HSPG2, IFNG, CCL2, IL6
11	behavior/neurological phenotype	MP:0005386	6.3	TGFB1, SHH, HSPG2, IFNG, CCL2, IL6
12	cardiovascular system phenotype	MP:0005385	6.2	HSPG2, SHH, TGFB1, CXCR3, IFNG, CCL2
13	cellular phenotype	MP:0005384	5.8	SLC7A1, CXCR3, TGFB1, SHH, HSPG2, IFNG
14	mortality/aging	MP:0010768	5.6	HSPG2, SHH, TGFB1, CXCR3, SLC7A1, IFNG

Articles related to nonspecific interstitial pneumonia:

(show all 12)

id	Title	Authors	Year	Affiliating Genes
1	HSP47 in lung fibroblasts is a predictor of survival in fibrotic nonspecific interstitial pneumonia. (20129768)	Amenomori M.... Kohno S.	2010	SERPINH1
2	Nonspecific interstitial pneumonia associated with collagen vascular disease: analysis of CT features to distinguish the various types. (19443969)	Daimon T.... Sugiyama Y.	2009	HSPG2
3	Expression of chemokine receptors CXCR3 and CCR4 in lymphocytes of idiopathic nonspecific interstitial pneumonia. (17137778)	Yoshinouchi T.... Ueda R.	2007	CXCR3, CCR4
4	Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia. (16448649)	Coon D.R.... Kradin R.	2006	SHH, FOXF1
5	Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene. (15557112)	Stevens P.A.... Beers M.F.	2005	SFTPC
6	Comparison of BALF concentrations of ENA-78 and IP10 in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. (16085216)	Nakayama S.... Kohno S.	2005	CXCR3, CXCL5
7	Increased levels of interleukin-18 in bronchoalveolar lavage fluid of patients with idiopathic nonspecific interstitial pneumonia. (15753633)	Ishii H.... Kohno S.	2005	IL18
8	Expression of HSP47 in usual interstitial pneumonia and nonspecific interstitial pneumonia. (15955241)	Kakugawa T.... Kohno S.	2005	SERPINH1
9	High-BAL fluid concentrations of RANTES in nonspecific interstitial pneumonia compared with usual interstitial pneumonia. (15481270)	Yoshioka S.... Kohno S.	2004	CCL2
10	Nonspecific interstitial pneumonia and usual interstitial pneumonia with mutation in surfactant protein C in familial pulmonary fibrosis. (15133475)	Chibbar R.... Lemire E.G.	2004	SFTPC
11	Different cytokine profiles in usual interstitial pneumonia and nonspecific interstitial pneumonia (12899768)	Gu L.... Zhu Y.J.	2003	TGFB1, FGF2, IL8
12	Increased levels of interleukin-6 are associated with lymphocytosis in bronchoalveolar lavage fluids of idiopathic nonspecific interstitial pneumonia. (10988147)	Park C.S.... Kitaichi M.	2000	IL6

Genes related to nonspecific interstitial pneumonia according to GeneCards:

(show all 20)

id	Symbol	Description	Score	GeneCards Section Context
1	FOXF1	forkhead box F1	11.0	Publications
2	SRXN1	sulfiredoxin 1	11.0
3	SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	11.0	Publications
4	SFTPC	surfactant protein C	11.0	Publications
5	SLC7A6	solute carrier family 7 (amino acid transporter light chain, y+L system), member 6	11.0
6	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
7	CXCL5	chemokine (C-X-C motif) ligand 5	11.0	Publications
8	SHH	sonic hedgehog	11.0	Publications
9	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
10	SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	11.0
11	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	11.0
12	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
13	IL13	interleukin 13	11.0	Publications
14	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
15	TGFB1	transforming growth factor, beta 1	11.0	Publications
16	IL8	interleukin 8	11.0	Publications
17	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
18	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
19	IFNG	interferon, gamma	11.0	Publications
20	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to nonspecific interstitial pneumonia according to GeneDecks:

(show all 49)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.6	CXCL5
2	NFAT Signaling and Lymphocyte Interactions36	10.0	CCL2, IL13
3	PGC1Alpha Pathway36	9.7	IL13, IL18, IL8
4	Regulation of eIF4 and p70S6K36	9.7	IL13, IL18, IL6
5	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.5	IL13, IL6, TGFB1
6	Activation of Genes by ATF438	9.4	CCL2, IL8
7	Pathways in cancer20	9.4	FGF2, SHH, TGFB1
8	Pertussis20	9.3	IL6, IL8, CXCL5
9	Cytokine production by Th17 cells in CF (Mouse model)41	9.1	IL6, IL8, TGFB1
10	Chemokine Signaling36	9.1	IL8, CCL2, CCR4, CXCL5, CXCR3
11	Chemokine signaling pathway20	9.1	CXCR3, CXCL5, CCR4, CCL2, IL8
12	African trypanosomiasis20	9.0	IFNG, IL6, IL18
13	NOD-like receptor signaling pathway20	9.0	CCL2, IL8, IL6, IL18
14	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.0	TGFB1, IFNG, IL6
15	Immune response_MIF-mediated glucocorticoid regulation41	8.9	IFNG, IL8, IL6
16	Immune response MIF-mediated glucocorticoid regulation10	8.9	IFNG, IL8, IL6
17	MSP-RON Signaling36	8.9	IFNG, CCL2, IL18
18	Immune response_MIF in innate immunity response41	8.9	IFNG, IL8, IL6
19	Immune response MIF in innate immunity response10	8.8	IFNG, IL8, IL6
20	Akt Signaling36	8.8	CXCR3, CXCL5, CCR4, CCL2, IL6, IL18
21	Immune response_Bacterial infections in normal airways41	8.8	IFNG, IL8, IL6
22	Molecular Mechanisms of Cancer36	8.8	TGFB1, CCR4, IL6, IL13, FGF2
23	Transendothelial Migration of Leukocytes36	8.7	CXCR3, CXCL5, HSPG2, CCR4, CCL2, IL8
24	Amoebiasis20	8.5	TGFB1, IFNG, IL8, IL6
25	MIF Mediated Glucocorticoid Regulation36	8.5	CXCL5, CCL2, IL8, IL6, IL18, IL13
26	MIF Regulation of Innate Immune Cells36	8.5	CXCL5, CCL2, IL8, IL6, IL18, IL13
27	all-trans-Retinoic Acid Signaling in Brain36	8.5	CXCL5, CCL2, IL8, IL6, IL18, IL13
28	PEDF Induced Signaling36	8.5	CXCL5, CCL2, IL8, IL6, IL18, IL13
29	IL-6 Pathway36	8.4	CXCL5, CCL2, IL8, IL6, IL18, IL13
30	Cytokine Network36	8.4	IFNG, IL8, IL6, IL18, IL13
31	Endothelin-1 Signaling Pathway36	8.4	IL13, IL18, IL6, IL8, CCL2, CXCL5
32	Glucocorticoid Receptor Signaling36	8.3	TGFB1, CCL2, IL8, IL6, IL18, IL13
33	Influenza A20	8.1	IFNG, CCL2, IL8, IL6, IL18
34	Chagas disease (American trypanosomiasis)20	8.1	TGFB1, IFNG, CCL2, IL8, IL6
35	Tuberculosis20	8.1	IL18, IL6, IFNG, TGFB1
36	SOCS Pathway36	8.1	CCL2, IL8, IL6, IL18, IL13, FGF2
37	STAT3 Pathway36	8.0	CXCR3, CXCL5, CCR4, CCL2, IL8, IL6
38	Malaria20	7.9	TGFB1, IFNG, CCL2, IL8, IL6, IL18
39	TGF-Beta Pathway36	7.7	TGFB1, CCL2, IL8, IL6, IL18, IL13
40	MAPK Family Pathway36	7.7	TGFB1, CCL2, IL8, IL6, IL18, IL13
41	Rheumatoid arthritis20	7.6	CXCL5, TGFB1, IFNG, CCL2, IL8, IL6
42	PAK Pathway36	7.5	CXCL5, TGFB1, CCL2, IL8, IL6, IL18
43	Tec Kinases Signaling36	7.2	CXCR3, TGFB1, CCR4, CCL2, IL8, IL6
44	Rho Family GTPases36	7.1	CXCL5, TGFB1, HSPG2, CCL2, IL8, IL6
45	ERK Signaling36	7.1	CXCL5, TGFB1, HSPG2, CCL2, IL8, IL6
46	Antioxidant Action of Vitamin-C36	7.0	CXCR3, CXCL5, TGFB1, CCR4, CCL2, IL8
47	p38 Signaling36	7.0	CCR4, TGFB1, CXCL5, CXCR3, CCL2, IL8
48	JAK-STAT Pathway36	6.9	TGFB1, IFNG, CCL2, IL8, IL6, IL18
49	Cytokine-cytokine receptor interaction20	6.8	IL13, CXCR3, CXCL5, TGFB1, IFNG, CCR4

Compounds related to nonspecific interstitial pneumonia according to GeneDecks:

(show top 50)    (show all 120)

id	Compound	Score	Top Affiliating Genes
1	sp 60012532 42	11.5	IL13
2	endotoxin32	10.1	CXCL5, CXCR3, IL18
3	pge232	9.3	IL13, HSPG2, FGF2, CXCL5
4	ccl432	9.2	IL13, CXCL5, CCR4, CCL2, CXCR3
5	mcp 132	9.1	CXCR3, IL6, IL8, CCL2
6	histamine32 18	10.1	IL13, IL18, CXCR3, HSPG2, CCL2
7	bleomycin32 9 9	11.0	CCL2, IL13, SFTPC, FGF2
8	mip 1alpha32	9.0	IL6, IL8, IL13, CCL2
9	lipoteichoic acid32	8.8	CCL2, IL8, IL6, IL18
10	tetracycline32 9 9	10.6	TGFB1, CCL2, IL18, FGF2, SFTPC
11	imiquimod32 42 9 9	11.6	IL6, IL8, IL18, IFNG
12	leukotriene b432 42 18	10.6	IL6, IL8, CCL2, IL13, CXCL5
13	sb 20358032 42	9.6	IFNG, IL6, IL13, FGF2
14	fmlp32	8.6	CXCR3, IL8, IL13, CCL2, HSPG2, CXCL5
15	ifn-alpha32	8.5	IFNG, IL6, IL18, CXCR3, IL13
16	etanercept32 9 9	10.5	CXCR3, IFNG, IL18, IL6, IL8
17	parthenolide32	8.4	IFNG, CCL2, IL8, IL6
18	polymyxin b32	8.4	CCL2, IL6, IFNG, IL8
19	poly(i-c)32	8.4	IL18, IL6, IL8, IFNG
20	pentoxifylline32 9 9	10.4	IFNG, IL8, IL13, IL18, IL6
21	vegf32	8.3	CXCL5, TGFB1, HSPG2, CCL2, SFTPC, FGF2
22	triptolide32	8.3	CCL2, IFNG, IL8, IL6
23	infliximab32 9 9	10.3	IL6, FGF2, IL18, IFNG, CXCR3
24	polyinosinic-polycytidylic acid32	8.3	IL18, IFNG, IL6, IL8
25	groalpha32	8.2	IL8, IL6, IL18, IL13, CXCL5, CCL2
26	bucillamine32	8.2	FGF2, IL6, IFNG
27	tgf beta132	8.1	FGF2, IL13, IL18, IL6, CCL2, TGFB1
28	prednisolone32 9 9	10.0	CCR4, IFNG, IL18, IL6, IL13, FGF2
29	il-1232	7.9	CCL2, IL13, IL6, IL18, IL8, IFNG
30	15-deoxy-delta-12,14-prostaglandin j232	7.8	FGF2, CCL2, IL8, IL6, IFNG
31	pdtc32	7.8	IL6, TGFB1, IL8, IL18, CCL2, IFNG
32	hydrocortisone32 9 9	9.8	IFNG, IL8, IL6, CXCR3, IL13, FGF2
33	indomethacin32 9 9	9.7	IFNG, IL6, IL18, IL13, TGFB1, HSPG2
34	tarc32	7.7	CXCR3, CXCL5, CCR4, IL8, IL18, IL13
35	simvastatin32 34 42 9 18 9	12.6	IL6, IL18, HSPG2, IL8, CCL2, CCR4
36	gm-csf32	7.5	IL13, IL18, TGFB1, IL8, IFNG, CCL2
37	arginine32	7.5	IFNG, CXCR3, SLC7A2, SLC7A6, SLC7A1, CCL2
38	herbimycin a32 42	8.5	IFNG, CCL2, FGF2, IL8, IL6, HSPG2
39	ly29400232	7.4	IL18, CXCR3, TGFB1, CCL2, IL6, IL8
40	il 1032	7.3	IL6, IL8, CCL2, IFNG, TGFB1, CXCR3
41	ccl332	7.2	CXCR3, CXCL5, IFNG, CCL2, IL13, IL18
42	thymidine32 18	8.2	IFNG, FGF2, IL18, IL6, IL13, TGFB1
43	cyclosporin a32 42	8.2	IL6, IL18, FGF2, SERPINH1, IFNG, IL8
44	pd 98,05932	7.1	CXCR3, FGF2, TGFB1, HSPG2, CCL2, IL8
45	actinomycin d32	7.0	IFNG, IL8, CCL2, IL6, IL13, FGF2
46	retinoic acid32 42 18	8.8	HSPG2, TGFB1, SFTPC, FGF2, IL13, IL18
47	rantes32	6.8	CXCR3, IL13, IL18, IL6, IL8, CCL2
48	nitric oxide32 9 18 9	9.6	IL6, IFNG, IL13, IL18, IL8, CCL2
49	cycloheximide32	6.3	FGF2, IL13, IL18, IL6, IL8, CCL2
50	dexamethasone32 42 34 9 9	9.8	FGF2, SFTPC, CXCR3, CXCL5, TGFB1, HSPG2

Cellular components related to nonspecific interstitial pneumonia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	8.8	IL13, CCR4, IFNG, CXCR3
2	extracellular region	GO:005576	5.5	IFNG, HSPG2, TGFB1, CXCL5, CCL2, IL8
3	extracellular space	GO:005615	5.3	SFTPC, CXCL5, TGFB1, SHH, HSPG2, IFNG

Biological processes related to nonspecific interstitial pneumonia according to GeneDecks:

(show all 29)

id	Name	GO ID	Score	Top Affiliating Genes
1	neutrophil apoptotic process	GO:001781	10.3	IL6
2	lung lobe morphogenesis	GO:060463	10.2	FOXF1, SHH
3	renal system development	GO:072001	10.1	FOXF1, SHH
4	embryonic foregut morphogenesis	GO:048617	10.0	FOXF1, SHH
5	amino acid transport	GO:006865	10.0	SLC7A1, SLC7A6, SLC7A2
6	cellular response to cytokine stimulus	GO:071345	9.9	FOXF1, IL13
7	stem cell development	GO:048864	9.8	SHH, FGF2
8	chemokine-mediated signaling pathway	GO:070098	9.8	CXCR3, CCR4, CCL2
9	cellular response to mechanical stimulus	GO:071260	9.8	SFTPC, IL13, IL18
10	regulation of vascular endothelial growth factor production	GO:010574	9.8	IL6, CCL2
11	lipopolysaccharide-mediated signaling pathway	GO:031663	9.6	IL18, CCL2, TGFB1
12	positive regulation of protein import into nucleus	GO:042307	9.5	SHH, TGFB1
13	cellular response to tumor necrosis factor	GO:071356	9.5	CCL2, IL8, IL18
14	lung development	GO:030324	9.5	FOXF1, FGF2, IL18, SHH
15	positive regulation of cell division	GO:051781	9.4	FGF2, SHH, TGFB1
16	cellular response to organic cyclic compound	GO:071407	9.4	FOXF1, IL18, CCL2, TGFB1
17	MAPK cascade	GO:000165	9.3	TGFB1, CCL2, IL18
18	response to hypoxia	GO:001666	9.2	TGFB1, SHH, CCL2, IL18
19	immune response	GO:006955	9.2	CXCL5, CCR4, IL8, IL18, IL13
20	neutrophil chemotaxis	GO:030593	9.0	IFNG, CCL2, IL8
21	chemotaxis	GO:006935	9.0	CXCR3, CXCL5, CCR4, CCL2, FGF2
22	cellular component movement	GO:006928	8.9	IL13, IL8, IFNG, CXCR3
23	humoral immune response	GO:006959	8.9	IFNG, CCL2, IL6
24	angiogenesis	GO:001525	8.9	CXCR3, HSPG2, CCL2, IL8, IL18
25	cellular response to lipopolysaccharide	GO:071222	8.9	IFNG, CCL2, IL8
26	positive regulation of cell proliferation	GO:008284	8.7	CXCL5, TGFB1, SHH, IL6, FGF2
27	positive regulation of transcription, DNA-dependent	GO:045893	8.4	TGFB1, SHH, IL6, FGF2, FOXF1
28	inflammatory response	GO:006954	8.1	IL13, TGFB1, CCR4, CCL2, IL8, IL6
29	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.0	FOXF1, FGF2, IL6, IFNG, SHH, TGFB1

Molecular functions related to nonspecific interstitial pneumonia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	9.3	IL8, CCL2, CXCL5
2	cytokine activity	GO:005125	7.5	FGF2, IL13, IL18, IL6, IFNG