NSIP
MCID: NNS002
MIFTS: 57

Nonspecific Interstitial Pneumonia (NSIP) malady

Respiratory diseases, Rare diseases categories
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Summaries for Nonspecific Interstitial Pneumonia

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Fully expand this MalaCard
Disease Ontology:8 An idiopathic interstitial pneumonia that occurs mainly in women, people who do not smoke, and people younger than 50 years with no known cause or risk factors. lung biopsies may show predominantly interstitial inflammation or fibrosis or a combination of inflammation and fibrosis. a dry cough and shortness of breath develop over 6 to 18 months. low-grade fever and a feeling of illness (malaise) may occur.

MalaCards: Nonspecific Interstitial Pneumonia, also known as NSIP, is related to pneumonia and pulmonary fibrosis. An important gene associated with Nonspecific Interstitial Pneumonia is FOXF1 (forkhead box F1), and among its related pathways are MSP-RON Signaling and Endochondral Ossification. The compounds ccl4 and mcp 1 have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and b cells, and related mouse phenotypes are craniofacial and embryogenesis.

Wikipedia:65 Non-specific interstitial pneumonia (NSIP) is a form of idiopathic interstitial pneumonia. more...

Aliases & Classifications for Nonspecific Interstitial Pneumonia

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8Disease Ontology, 62UMLS, 49Orphanet, 40NCIt, 58SNOMED-CT, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

nonspecific interstitial pneumonia 8 62
nsip 8 49
non-specific idiopathic interstitial pneumonia 49
non-specific interstitial pneumonia 49


External Ids:

Disease Ontology8 DOID:2801
NCIt40 C35717
ICD10 via Orphanet26 J84.8
SNOMED-CT58 129452008
SNOMED-CT via Orphanet59 129452008
UMLS via Orphanet63 C1290344

Related Diseases for Nonspecific Interstitial Pneumonia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Nonspecific Interstitial Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.6IL13, IL6, IL8, CCL2, CXCL5, TGFB1
2pulmonary fibrosis31.0IL13, IL8, CCR4, CCL2, CXCR3, SERPINH1
3interstitial lung disease30.8CCL2
4idiopathic pulmonary fibrosis30.7SFTPC, TGFB1, SERPINH1, CXCR3, FGF2, IL13
5vascular disease30.6IL8, IL6, FGF2
6arthritis30.6IL6, IL8
7connective tissue disease30.5IL6, CCL2, TGFB1
8bronchiolitis30.4IL13, IL8
9rheumatoid arthritis30.2IL13, IL6, IL8, IL18, IFNG, CCR4
10usual interstitial pneumonia10.9
11idiopathic interstitial pneumonia10.6
12acute interstitial pneumonia10.4
13dermatomyositis10.4
14cryptogenic organizing pneumonia10.2
15primary biliary cirrhosis10.2
16congestive heart failure10.2
17pulmonary function10.2
18kaposi's sarcoma10.2
19respiratory bronchiolitis-associated interstitial lung disease10.2
20hypertension10.2
21multiple myeloma10.2
22myeloma10.2
23sarcoma10.2
24scleroderma10.2
25thymoma10.2
26amyopathic dermatomyositis10.2
27polymyositis10.2
28funisitis10.1SERPINH1
29cervical incompetence10.1SERPINH1
30adult t-cell leukemia10.1SERPINH1
31intermediate uveitis10.1CXCR3, CCR4
32malaria10.1IFNG
33contact dermatitis10.1CCR4, CXCR3
34lymphomatoid papulosis10.1CCR4, CXCR3
35periapical granuloma10.1CXCR3, CCL2
36allergic contact dermatitis10.1CCR4, CXCR3
37vacterl association10.1SHH, FOXF1
38proliferative glomerulonephritis10.1CXCR3, CCL2
39pulmonary alveolar proteinosis10.1SFTPC, CCL2
40lipoid nephrosis10.1IL13, CCL2
41adult-onset still's disease10.1IL18, IL6
42bronchiolitis obliterans10.1CXCR3, IL8
43pulmonary eosinophilia10.1IL8, IL13
44bacterial vaginosis10.1IL8, SERPINH1
45cork-handlers' disease10.1IL8, CXCL5, SFTPC
46cutaneous leishmaniasis10.0IL13, IFNG
47membranous glomerulonephritis10.0CCL2, HSPG2
48nephritis10.0CXCR3, CCL2, IL18
49vernal keratoconjunctivitis10.0CXCR3, IL8, IL13
50viral meningitis10.0IL8, IL6

Graphical network of the top 20 diseases related to Nonspecific Interstitial Pneumonia:



Diseases related to nonspecific interstitial pneumonia

Symptoms for Nonspecific Interstitial Pneumonia

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Drugs & Therapeutics for Nonspecific Interstitial Pneumonia

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42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Nonspecific Interstitial Pneumonia

Search NIH Clinical Center for Nonspecific Interstitial Pneumonia

Genetic Tests for Nonspecific Interstitial Pneumonia

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Anatomical Context for Nonspecific Interstitial Pneumonia

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33MalaCards
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MalaCards organs/tissues related to Nonspecific Interstitial Pneumonia:

33
Lung, T cells, B cells

Animal Models for Nonspecific Interstitial Pneumonia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Nonspecific Interstitial Pneumonia:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.1SHH, HSPG2, TGFB1, SERPINH1, CCL2, IFNG
2MP:00053808.1SHH, HSPG2, TGFB1, SERPINH1, FOXF1, IFNG
3MP:00053678.0IL6, IFNG, CXCR3, TGFB1, SHH
4MP:00053897.7SFTPC, SHH, TGFB1, CCL2, IFNG, IL13
5MP:00053907.6SHH, HSPG2, SERPINH1, CCL2, IFNG, IL6
6MP:00053707.5HSPG2, TGFB1, CCL2, IFNG, IL6
7MP:00020067.2SFTPC, SHH, TGFB1, CXCR3, CCL2, IFNG
8MP:00107717.1SHH, HSPG2, TGFB1, CCL2, IFNG, IL18
9MP:00053916.8SFTPC, SHH, HSPG2, TGFB1, CCL2, IFNG
10MP:00053696.8SHH, HSPG2, TGFB1, FOXF1, CCL2, IFNG
11MP:00053816.7SHH, HSPG2, TGFB1, SERPINH1, FOXF1, CCL2
12MP:00053866.7SFTPC, SHH, HSPG2, TGFB1, CCL2, IFNG
13MP:00036316.7SHH, HSPG2, TGFB1, SERPINH1, CCL2, IFNG
14MP:00053786.6SFTPC, SHH, HSPG2, TGFB1, SERPINH1, CCL2
15MP:00053846.5SHH, HSPG2, TGFB1, CXCR3, CCL2, IFNG
16MP:00053886.4IL13, SFTPC, SHH, HSPG2, TGFB1, SERPINH1
17MP:00053766.4CXCR3, TGFB1, HSPG2, SHH, CCL2, IFNG
18MP:00053856.1SERPINH1, TGFB1, HSPG2, SHH, SFTPC, CXCR3
19MP:00107685.8SERPINH1, TGFB1, HSPG2, SHH, SFTPC, CXCR3
20MP:00053875.7CXCR3, TGFB1, HSPG2, SHH, SFTPC, CCL2
21MP:00053975.6CCL2, CXCR3, TGFB1, HSPG2, SHH, CCR4

Publications for Nonspecific Interstitial Pneumonia

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52PubMed
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Articles related to Nonspecific Interstitial Pneumonia:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
The difference of neovascularization in early intra-alveolar fibrosis between nonspecific interstitial pneumonia and usual interstitial pneumonia. (23714250)
2013
2
Airspace enlargement with fibrosis shows characteristic histology and immunohistology different from usual interstitial pneumonia, nonspecific interstitial pneumonia and centrilobular emphysema. (23692421)
2013
3
Severe pulmonary hypertension in idiopathic nonspecific interstitial pneumonia. (22558525)
2012
4
Infliximab-induced nonspecific interstitial pneumonia. (22688498)
2012
5
Usual interstitial pneumonia and nonspecific interstitial pneumonia: correlation between CT findings at the site of biopsy with pathological diagnoses. (22169358)
2012
6
Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia. (22797508)
2012
7
Pulmonary dendritic cell accumulation in usual interstitial pneumonia and nonspecific interstitial pneumonia. (23311128)
2012
8
Idiopathic nonspecific interstitial pneumonia: an interstitial lung disease associated with autoimmune disorders? (21273390)
2011
9
Thalidomide induced nonspecific interstitial pneumonia in patient with relapsed multiple myeloma. (21179284)
2010
10
Distinct prognosis of idiopathic nonspecific interstitial pneumonia (NSIP) fulfilling criteria for undifferentiated connective tissue disease (UCTD). (20483576)
2010
11
Understanding nonspecific interstitial pneumonia: the need for a diagnostic gold standard. (19158329)
2009
12
Nonspecific interstitial pneumonia pattern as pulmonary involvement in human T-cell lymphotropic virus type 1 carriers. (19856065)
2009
13
Nonspecific interstitial pneumonia: histologic correlation with high-resolution CT in 29 patients. (18242033)
2009
14
Nonspecific interstitial pneumonia (NSIP) associated with anti-KS antibody: differentiation from idiopathic NSIP. (19652435)
2009
15
Nonspecific interstitial pneumonia with abundant IgG4-positive cells infiltration, which was thought as pulmonary involvement of IgG4-related autoimmune disease. (18277032)
2008
16
Idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia should stay separate. (18448513)
2008
17
Expression of chemokine receptors CXCR3 and CCR4 in lymphocytes of idiopathic nonspecific interstitial pneumonia. (17137778)
2007
18
Nonspecific interstitial pneumonia: pathologic features and clinical implications. (17882901)
2007
19
Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease? (17556720)
2007
20
Volume histogram analysis for lung thin-section computed tomography: differentiation between usual interstitial pneumonia and nonspecific interstitial pneumonia. (18043360)
2007
21
Idiopathic and collagen vascular disease nonspecific interstitial pneumonia: clinical significance of remodeling process. (17294340)
2007
22
Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia. (16448649)
2006
23
Nonspecific interstitial pneumonia. (17195141)
2006
24
Iatrogenic Kaposi's sarcoma following steroid therapy for nonspecific interstitial pneumonia with HHV-8 genotyping. (16413694)
2006
25
Respiratory bronchiolitis-associated interstitial lung disease with fibrosis is a lesion distinct from fibrotic nonspecific interstitial pneumonia: a proposal. (16951670)
2006
26
Differential diagnosis between usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) assessed by high-resolution computed tomography (HRCT). (15973221)
2005
27
Pathologic subgroups of nonspecific interstitial pneumonia: differential diagnosis from other idiopathic interstitial pneumonias on high-resolution computed tomography. (16272854)
2005
28
Comparison of BALF concentrations of ENA-78 and IP10 in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. (16085216)
2005
29
Increased levels of interleukin-18 in bronchoalveolar lavage fluid of patients with idiopathic nonspecific interstitial pneumonia. (15753633)
2005
30
High-resolution computed tomography features of nonspecific interstitial pneumonia and usual interstitial pneumonia. (15891504)
2005
31
Nonspecific interstitial pneumonia with poor prognosis associated with amyopathic dermatomyositis. (15497521)
2004
32
High-BAL fluid concentrations of RANTES in nonspecific interstitial pneumonia compared with usual interstitial pneumonia. (15481270)
2004
33
Nonspecific interstitial pneumonia and usual interstitial pneumonia with mutation in surfactant protein C in familial pulmonary fibrosis. (15133475)
2004
34
Nonspecific interstitial pneumonia in collagen vascular diseases: comparison of the clinical characteristics and prognostic significance with usual interstitial pneumonia. (14620168)
2003
35
BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia. (12952254)
2003
36
Nonspecific interstitial pneumonia associated with polymyositis and dermatomyositis: serial high-resolution CT findings and functional correlation. (12684299)
2003
37
Different cytokine profiles in usual interstitial pneumonia and nonspecific interstitial pneumonia]. (12899768)
2003
38
Nonspecific interstitial pneumonia: correlation between thin-section CT findings and pathologic subgroups in 55 patients. (12355005)
2002
39
Nonspecific interstitial pneumonia as pulmonary involvement of primary SjAPgren's syndrome. (12111081)
2002
40
Survival of patients with biopsy-proven usual interstitial pneumonia and nonspecific interstitial pneumonia. (12108865)
2002
41
Nonspecific interstitial pneumonia and systemic sclerosis. (12070054)
2002
42
Nonspecific interstitial pneumonia/fibrosis completely recovered by adding cyclophosphamide to corticosteroids. (12413012)
2002
43
The major histopathologic pattern of pulmonary fibrosis in scleroderma is nonspecific interstitial pneumonia. (12108451)
2002
44
An unusual case of nonspecific interstitial pneumonia treated initially with surgical resection. (12380731)
2002
45
Nonspecific interstitial pneumonia and usual interstitial pneumonia: comparative appearances at and diagnostic accuracy of thin-section CT. (11719652)
2001
46
Increased levels of interleukin-6 are associated with lymphocytosis in bronchoalveolar lavage fluids of idiopathic nonspecific interstitial pneumonia. (10988147)
2000
47
Fibroblast contractility: usual interstitial pneumonia and nonspecific interstitial pneumonia. (11112149)
2000
48
A histologic pattern of nonspecific interstitial pneumonia is associated with a better prognosis than usual interstitial pneumonia in patients with cryptogenic fibrosing alveolitis. (10471616)
1999
49
Nonspecific interstitial pneumonia with fibrosis: radiographic and CT findings in seven patients. (7753988)
1995
50
Nonspecific interstitial pneumonia/fibrosis. Histologic features and clinical significance. (8291652)
1994

Variations for Nonspecific Interstitial Pneumonia

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Expression for genes affiliated with Nonspecific Interstitial Pneumonia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nonspecific Interstitial Pneumonia

Search GEO for disease gene expression data for Nonspecific Interstitial Pneumonia.

Pathways for genes affiliated with Nonspecific Interstitial Pneumonia

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 54R&D Systems, 60Thomson Reuters
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Pathways related to Nonspecific Interstitial Pneumonia according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3IFNG, IL18, CCL2
29.2SERPINH1, FGF2, TGFB1
3
Show member pathways
Proteogylcan syndecan-mediated signaling events38
9.1FGF2, HSPG2, TGFB1
49.0IL6, CCL2, CXCL5
59.0CXCL5, IL6, IL8
68.9IL18, IL8, IL6
7
Show member pathways
Type III interferon signaling38
8.8IFNG, IL6, IL13
8
Show member pathways
8.8FGF2, TGFB1, SERPINH1, HSPG2
98.8CCL2, IL8, IL6
108.8IL6, IL18, IFNG
11
Show member pathways
thioredoxin pathway38
8.8IL6, CCL2, IFNG
128.7TGFB1, IL6, IL13
138.7TGFB1, IFNG, IL18, IL13
148.7IL8, IL6, IFNG
158.7IL6, IFNG, IL8
16
Show member pathways
Immune response MIF in innate immunity response60
8.7IL6, IFNG, IL8
17
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.7IFNG, IL8, IL6
18
Show member pathways
8.6IL8, CCL2, CXCL5, CXCR3, CCR4
19
Show member pathways
8.6CCR4, IL8, CCL2, CXCR3, CXCL5
20
Show member pathways
8.6IL6, IL8, TGFB1
21
Show member pathways
8.5IL6, IFNG, TGFB1
228.5TGFB1, IL6, IFNG
23
Show member pathways
8.5IL6, IL8, IL18, CCL2
248.4IL8, IL6, IFNG, IL13
25
Show member pathways
8.4IL18, IFNG, IL6, IL8
26
Show member pathways
8.3CCR4, CXCR3, SHH, CXCL5, CCL2, IL8
27
Show member pathways
8.3IL6, FGF2, TGFB1, HSPG2
28
Show member pathways
8.2IL6, TGFB1, FGF2, CCL2
298.2IL13, TGFB1, IFNG, IL6
308.2IFNG, IL18, IL6, TGFB1
31
Show member pathways
IL27-mediated signaling events38
8.2IL18, TGFB1, IL6, IFNG
328.1TGFB1, IL6, IFNG, IL8
338.1IL18, IL8, IL6, IL13, IFNG
348.1IL6, TGFB1, IL8, IFNG
35
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.0FGF2, IL6, IFNG, IL18, CCL2
36
Show member pathways
7.9IL13, IFNG, IL18, IL6, TGFB1
37
Show member pathways
7.9IL13, IL18, IL6, IFNG, TGFB1
387.9FGF2, IL6, SHH, TGFB1, IL8
39
Show member pathways
7.7IL13, IL6, IL8, CCL2, IFNG, IL18
407.7IL6, TGFB1, IL8, IFNG, CCL2
41
Show member pathways
7.7HSPG2, IL8, TGFB1, CXCR3, CXCL5, CCL2
427.4IL6, IL8, IL18, IFNG, CCL2, TGFB1
43
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
7.3CCL2, IL6, IL8, HSPG2, TGFB1, IFNG
447.1CXCL5, CCL2, IFNG, IL18, IL8, IL6
45
Show member pathways
7.0CXCL5, CXCR3, CCL2, CCR4, IL8, TGFB1
46
Show member pathways
6.6TGFB1, IFNG, CCL2, IL18, IL8, IL6
47
Show member pathways
6.2IL6, IL8, IL18, TGFB1, CXCL5, CCL2
48
Show member pathways
6.2CXCR3, CCL2, CXCL5, CCR4, TGFB1, FGF2
49
Show member pathways
6.0IL13, IL6, IL18, TGFB1, IL8, IFNG
50
Show member pathways
5.8FGF2, HSPG2, TGFB1, CXCR3, CXCL5, IL6

Compounds for genes affiliated with Nonspecific Interstitial Pneumonia

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Nonspecific Interstitial Pneumonia according to GeneCards/GeneDecks:

(show top 50)    (show all 179)
idCompoundScoreTop Affiliating Genes
1ccl445 2910.1CCR4, CCL2, CXCL5, CXCR3, IL13
2mcp 1458.9CCL2, IL8, CXCR3, IL6
3fmlp458.8IL13, HSPG2, CCL2, CXCL5, CXCR3, IL8
4mip 1alpha458.8CCL2, IL13, IL6, IL8
5bleomycin45 119.8FGF2, CCL2, SFTPC, IL13, TGFB1
6tetracycline45 119.8SFTPC, FGF2, CCL2, TGFB1, IL18
7imiquimod45 61 29 1111.6IFNG, IL6, IL8, IL18
8ifn-alpha458.6IL6, CXCR3, IL18, IFNG, IL13
9lipoteichoic acid458.5IL8, CCL2, IL18, IL6
10infliximab45 51 1110.5IL6, IL18, CXCR3, FGF2, IFNG
11leukotriene b445 61 2410.5CXCL5, IL6, IL13, CCL2, IL8
12etanercept45 51 1110.5IFNG, IL18, IL8, CXCR3, IL6
13polymyxin b458.5CCL2, IFNG, IL8, IL6
14triptolide458.4CCL2, IL6, IL8, IFNG
15pentoxifylline45 119.4IL8, IFNG, IL13, IL6, IL18
16parthenolide45 39.4CCL2, IFNG, IL8, IL6
17thalidomide45 51 61 1111.3IL18, IL6, IL13, FGF2, IFNG
1815-deoxy-delta-12,14-prostaglandin j2458.2IFNG, FGF2, IL8, CCL2, IL6
19groalpha458.1CXCR3, IL6, CXCL5, CCL2, IL18, IL8
20il-12458.1IL6, IL13, IL8, IL18, IFNG, CCL2
21hydrocortisone45 3 61 1111.1IL13, IL6, IL8, CXCR3, IFNG, FGF2
22polyinosinic-polycytidylic acid458.1IL6, IFNG, IL18, IL8
23tgf beta1458.0IL6, IL13, TGFB1, IL18, CCL2, FGF2
24sp 60012545 619.0TGFB1, IL8, IL18, IL13, IL6, CCL2
25prednisolone45 29 1110.0CCR4, IFNG, IL18, IL13, FGF2, IL6
26tarc457.9IL13, CXCR3, CXCL5, CCL2, IL8, IL18
27herbimycin a45 618.9IL6, HSPG2, CCL2, IFNG, IL8, FGF2
28hyaluronic acid45 248.9IL6, IL13, TGFB1, IL8, FGF2
29pdtc457.8IL18, CCL2, TGFB1, IL6, IL8, IFNG
30indomethacin45 29 61 1110.7IL18, TGFB1, IFNG, HSPG2, IL13, IL6
31endotoxin457.6IL8, IL13, IL6, IL18, IFNG, CCL2
32simvastatin45 51 61 29 24 1112.5HSPG2, CCL2, CCR4, IFNG, IL18, IL8
33gm-csf45 298.5CCL2, IFNG, IL18, IL8, IL6, IL13
34thymidine45 248.5IL18, TGFB1, IL6, FGF2, CXCR3, IFNG
35nitric oxide45 24 119.3IL8, IL13, CXCR3, CCL2, CXCL5, SERPINH1
36il 10457.2TGFB1, CXCR3, CCL2, IFNG, IL18, IL8
37cyclosporin a45 29 619.1IL8, IL6, IFNG, FGF2, TGFB1, SERPINH1
38actinomycin d457.1TGFB1, FGF2, CCL2, IFNG, IL8, IL6
39ccl345 298.1IL13, IL6, IL8, IL18, CXCR3, CXCL5
40sb 20358045 618.1TGFB1, CCL2, IFNG, IL18, IL8, IL6
41serine457.0IL8, HSPG2, TGFB1, SERPINH1, IL13, CXCR3
42pd 98,059457.0HSPG2, TGFB1, CXCR3, CCL2, IL8, FGF2
43ly294002457.0HSPG2, FGF2, TGFB1, CXCR3, CCL2, IL18
44histamine45 29 248.9TGFB1, CXCR3, IFNG, CCL2, IL13, IL6
45retinoic acid45 247.7FGF2, IL13, IL18, IFNG, TGFB1, HSPG2
46cycloheximide456.5IL8, IL18, IFNG, FGF2, TGFB1, HSPG2
47rantes456.5CXCR3, CXCL5, CCL2, CCR4, IFNG, IL18
48pge2456.2FGF2, HSPG2, TGFB1, IL13, IL6, IL8
49dexamethasone45 51 29 119.0CXCR3, TGFB1, HSPG2, SFTPC, CXCL5, IL13
50vegf455.7CXCL5, CXCR3, SERPINH1, HSPG2, SFTPC, TGFB1

GO Terms for genes affiliated with Nonspecific Interstitial Pneumonia

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16Gene Ontology
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Cellular components related to Nonspecific Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.1CCR4, IFNG, IL6, IL13, CXCR3
2extracellular regionGO:0055765.8HSPG2, TGFB1, CXCL5, CCL2, IFNG, IL18
3extracellular spaceGO:0056155.2FGF2, SFTPC, SHH, HSPG2, TGFB1, SERPINH1

Biological processes related to Nonspecific Interstitial Pneumonia according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idNameGO IDScoreTop Affiliating Genes
1lung lobe morphogenesisGO:06046310.4SHH, FOXF1
2renal system developmentGO:07200110.3SHH, FOXF1
3embryonic foregut morphogenesisGO:04861710.3SHH, FOXF1
4stem cell developmentGO:04886410.2SHH, FGF2
5cellular response to cytokine stimulusGO:07134510.1IL13, FOXF1
6neutrophil apoptotic processGO:00178110.1IL6
7embryonic digestive tract morphogenesisGO:04855710.0SHH, FOXF1
8positive regulation of chemotaxisGO:05092110.0TGFB1, CXCR3
9lung developmentGO:0303249.9FGF2, FOXF1, SHH
10positive regulation of release of sequestered calcium ion into cytosolGO:0512819.9IL13, CXCR3
11positive regulation of interleukin-17 productionGO:0327409.9TGFB1, IL18
12positive regulation of protein import into nucleusGO:0423079.8TGFB1, SHH
13cellular response to fibroblast growth factor stimulusGO:0443449.8IL8, CCL2
14epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.7IL6, SHH
15hyaluronan catabolic processGO:0302149.7FGF2, TGFB1
16negative regulation of blood vessel endothelial cell migrationGO:0435379.7FGF2, TGFB1
17cell-cell signalingGO:0072679.7SHH, CXCL5, IL18, IL13
18branching involved in salivary gland morphogenesisGO:0604459.7IL6, SHH
19regulation of vascular endothelial growth factor productionGO:0105749.7CCL2, IL6
20pancreas developmentGO:0310169.7FOXF1, SHH
21positive regulation of blood vessel endothelial cell migrationGO:0435369.6FGF2, TGFB1
22lipopolysaccharide-mediated signaling pathwayGO:0316639.6IL18, CCL2, TGFB1
23response to bacteriumGO:0096179.6CCL2, CCR4
24positive regulation of cell divisionGO:0517819.6FGF2, TGFB1, SHH
25MAPK cascadeGO:0001659.6IL18, CCL2, TGFB1
26neutrophil chemotaxisGO:0305939.5CCL2, IFNG, IL8
27cellular response to lipopolysaccharideGO:0712229.5IL8, IFNG, CCL2
28monocyte chemotaxisGO:0025489.5IL6, CCL2
29endoplasmic reticulum unfolded protein responseGO:0309689.5IL8, IFNG, CCL2
30response to glucocorticoidGO:0513849.4SFTPC, CCL2, IL6
31response to lipopolysaccharideGO:0324969.4SFTPC, IL6, IL13
32cellular response to organic cyclic compoundGO:0714079.4TGFB1, FOXF1, CCL2, IL18
33cellular component movementGO:0069289.4CXCR3, IFNG, IL8, IL13
34defense response to protozoanGO:0428329.4IL6, IFNG
35cell surface receptor signaling pathwayGO:0071669.2IFNG, CCL2, CXCR3
36response to antibioticGO:0466779.2IL6, CCR4, CCL2
37humoral immune responseGO:0069599.2IL6, IFNG, CCL2
38angiogenesisGO:0015259.2HSPG2, CXCR3, CCL2, IL18, IL8
39cell cycle arrestGO:0070509.1TGFB1, IFNG, IL8
40immune responseGO:0069559.1CXCL5, CCR4, IL18, IL8, IL13
41extracellular matrix organizationGO:0301989.0FGF2, FOXF1, SERPINH1, TGFB1, HSPG2
42agingGO:0075689.0TGFB1, CCL2, IL6
43signal transductionGO:0071658.9CXCL5, CCL2, IL8, IL13, FGF2
44chemotaxisGO:0069358.7CXCR3, CXCL5, CCL2, CCR4, IL8, FGF2
45positive regulation of transcription, DNA-templatedGO:0458938.5SHH, TGFB1, FOXF1, IL6, FGF2
46response to drugGO:0424938.5TGFB1, CCL2, IFNG, IL6
47negative regulation of cell proliferationGO:0082858.5TGFB1, IL8, IL6, FGF2
48positive regulation of cell proliferationGO:0082848.3SHH, TGFB1, CXCR3, CXCL5, IL6, FGF2
49positive regulation of transcription from RNA polymerase II promoterGO:0459447.8SHH, TGFB1, CXCR3, FOXF1, IFNG, IL6
50inflammatory responseGO:0069547.3IL13, TGFB1, CXCR3, CCL2, CCR4, IL18

Molecular functions related to Nonspecific Interstitial Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.4CCR4, CXCR3
2chemokine activityGO:0080099.3CXCL5, CCL2, IL8
3growth factor activityGO:0080838.6FGF2, IL6, TGFB1
4cytokine activityGO:0051258.1FGF2, IL13, IL6, IL18, IFNG

Products for genes affiliated with Nonspecific Interstitial Pneumonia

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  • Antibodies
  • Proteins
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Sources for Nonspecific Interstitial Pneumonia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet