MCID: NNS038
MIFTS: 21

Nonsyndromic Congenital Nail Disorder 1 malady

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Nonsyndromic Congenital Nail Disorder 1

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Aliases & Descriptions for Nonsyndromic Congenital Nail Disorder 1:

Name: Nonsyndromic Congenital Nail Disorder 1 10 12
Twenty-Nail Dystrophy 10 45 51
Autosomal Dominant Nail Dysplasia 45 51
 
Onychodystrophy Totalis 45 51
Onychodystrophy Totalis, Isolated 45
Twenty Nail Dystrophy 65

Characteristics:

Orphanet epidemiological data:

51
twenty-nail dystrophy:
Inheritance: Autosomal dominant; Age of onset: Childhood; Age of death: normal life expectancy

Classifications:

Orphanet: 51 
Rare skin diseases


External Ids:

Disease Ontology10 DOID:0080079
Orphanet51 79153
ICD10 via Orphanet28 L60.3
UMLS65 C0406443

Summaries for Nonsyndromic Congenital Nail Disorder 1

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NIH Rare Diseases:45 Twenty-nail dystrophy is a condition that affects the nails of the fingers and toes.  the surface of all twenty nails develop ridges, splitting, and roughening (similar to sandpaper).  the nails may also be dull and brittle. this condition most commonly occurs in childhood, but it can occur at any age.  the exact cause is unknown; but in some cases, it appears to be associated with other skin conditions such as lichen planus, eczema, psoriasis and alopecia areata. many cases of twenty-nail dystrophy that begin gradually in early childhood tend to disappear naturally as the child ages. last updated: 7/4/2012

MalaCards based summary: Nonsyndromic Congenital Nail Disorder 1, also known as twenty-nail dystrophy, is related to vernal conjunctivitis and prostatitis. An important gene associated with Nonsyndromic Congenital Nail Disorder 1 is FZD6 (Frizzled Class Receptor 6), and among its related pathways is Primary immunodeficiency. Affiliated tissues include skin, and related mouse phenotypes are no phenotypic analysis and normal.

Related Diseases for Nonsyndromic Congenital Nail Disorder 1

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Diseases in the Nail Disease family:

Nail Disorder, Nonsyndromic Congenital, 3, Nail Disorder, Nonsyndromic Congenital, 10,
Nail Disorder, Nonsyndromic Congenital, 7 Nail Disorder, Nonsyndromic Congenital, 9
nonsyndromic congenital nail disorder 1 Nonsyndromic Congenital Nail Disorder 2
Nonsyndromic Congenital Nail Disorder 5 Nonsyndromic Congenital Nail Disorder 6

Diseases related to Nonsyndromic Congenital Nail Disorder 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1vernal conjunctivitis30.3AIRE, CD79A
2prostatitis10.4
3mowat-wilson syndrome10.3
4renal cell carcinoma10.3
5chordoma10.3
6becker muscular dystrophy10.3
7leukemia10.3
8sensorineural hearing loss10.3
9pinguecula10.3
10hydronephrosis10.3
11pseudotumor cerebri10.3
12porphyria10.3
13duodenal ulcer10.3
14bursitis10.3
15teratoma10.3
16retinitis10.3
17gastric teratoma10.3
18conjunctivitis10.3
19compartment syndrome10.3
20thyroiditis10.3
21monocytic leukemia10.3
22duodenitis10.3
23leishmaniasis10.3
24muscular dystrophy10.3
25sickle cell disease10.3
26anaplastic ependymoma10.3
27ependymoma10.3
28hypotrichosis 710.2TBX22, TP63
29hemosiderosis10.1CD79A, TP63
30cervical incompetence10.1CD79A, TP63
31bladder urothelial papillary carcinoma10.1CD79A, TP63
32auriculocondylar syndrome 310.1TBX22, TP63
33dacryocystocele10.1CD79A, TP63
34spondylocostal dysostosis10.0TBX22, TP63
35dysbaric osteonecrosis10.0TBX22, TP63
36myasthenic syndrome, congenital, 2a, slow-channel9.9TBX22, TP63
37otosclerosis 49.8MBTPS2, TP63
38small intestinal vasoactive intestinal peptide producing tumor9.8CD79A, MBTPS2
39rh isoimmunization9.8AIRE, CD79A
40avoidant personality disorder9.6AIRE, CD79A
41alpha 1-antitrypsin deficiency9.5AIRE, MBTPS2, TP63
42nonsyndromic congenital nail disorder 28.4AIRE, CD79A, FZD6, MBTPS2, PROS1, TBX22

Graphical network of the top 20 diseases related to Nonsyndromic Congenital Nail Disorder 1:



Diseases related to nonsyndromic congenital nail disorder 1

Symptoms for Nonsyndromic Congenital Nail Disorder 1

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Drugs & Therapeutics for Nonsyndromic Congenital Nail Disorder 1

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Nonsyndromic Congenital Nail Disorder 1

Genetic Tests for Nonsyndromic Congenital Nail Disorder 1

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Anatomical Context for Nonsyndromic Congenital Nail Disorder 1

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MalaCards organs/tissues related to Nonsyndromic Congenital Nail Disorder 1:

33
Skin

Animal Models for Nonsyndromic Congenital Nail Disorder 1 or affiliated genes

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MGI Mouse Phenotypes related to Nonsyndromic Congenital Nail Disorder 1:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4AIRE, CD79A, PROS1, TP63
2MP:00028737.3AIRE, CD79A, FZD6, PROS1, TBX22, TP63

Publications for Nonsyndromic Congenital Nail Disorder 1

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Variations for Nonsyndromic Congenital Nail Disorder 1

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Expression for genes affiliated with Nonsyndromic Congenital Nail Disorder 1

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Search GEO for disease gene expression data for Nonsyndromic Congenital Nail Disorder 1.

Pathways for genes affiliated with Nonsyndromic Congenital Nail Disorder 1

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Pathways related to Nonsyndromic Congenital Nail Disorder 1 according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3AIRE, CD79A

GO Terms for genes affiliated with Nonsyndromic Congenital Nail Disorder 1

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Sources for Nonsyndromic Congenital Nail Disorder 1

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet