MCID: NNS014
MIFTS: 22

Nonsyndromic Hearing Loss and Deafness malady

Categories: Genetic diseases (common), Ear diseases

Aliases & Classifications for Nonsyndromic Hearing Loss and Deafness

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Aliases & Descriptions for Nonsyndromic Hearing Loss and Deafness:

Name: Nonsyndromic Hearing Loss and Deafness 23

Classifications:



Summaries for Nonsyndromic Hearing Loss and Deafness

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MalaCards based summary: Nonsyndromic Hearing Loss and Deafness is related to nonsyndromic hearing loss and deafness, mitochondrial and nonsyndromic hearing loss and deafness, autosomal recessive. An important gene associated with Nonsyndromic Hearing Loss and Deafness is GJB2 (Gap Junction Protein Beta 2), and among its related pathways are Myometrial Relaxation and Contraction Pathways and Signaling in Gap Junctions.

Related Diseases for Nonsyndromic Hearing Loss and Deafness

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Diseases related to Nonsyndromic Hearing Loss and Deafness via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1nonsyndromic hearing loss and deafness, mitochondrial34.4GJB2, GJB6
2nonsyndromic hearing loss and deafness, autosomal recessive28.4GJB2, GJB3, GJB6, MT-CO1, MT-RNR1, MT-TS1
3dfnx1 nonsyndromic hearing loss and deafness12.5
4dfnb 7/11 nonsyndromic hearing loss and deafness12.4
5nonsyndromic hearing loss and deafness, dfna312.3
6nonsyndromic hearing loss and deafness, dfnb112.3
7dfnb 8/10 nonsyndromic hearing loss and deafness12.3
8dfna 3 nonsyndromic hearing loss and deafness12.3
9dfnb 1 nonsyndromic hearing loss and deafness12.2
10nonsyndromic hearing loss and deafness, autosomal dominant12.2
11dfna 1 nonsyndromic hearing loss and deafness12.2
12dfna 4 nonsyndromic hearing loss and deafness12.2
13dfna 5 nonsyndromic hearing loss and deafness12.2
14dfna 8/12 nonsyndromic hearing loss and deafness12.2
15dfna10 nonsyndromic hearing loss and deafness12.2
16dfna11 nonsyndromic hearing loss and deafness12.2
17dfna13 nonsyndromic hearing loss and deafness12.2
18dfna15 nonsyndromic hearing loss and deafness12.2
19dfna17 nonsyndromic hearing loss and deafness12.2
20dfna22 nonsyndromic hearing loss and deafness12.2
21dfna23 nonsyndromic hearing loss and deafness12.2
22dfna36 nonsyndromic hearing loss and deafness12.2
23dfna44 nonsyndromic hearing loss and deafness12.2
24dfnb 3 nonsyndromic hearing loss and deafness12.2
25dfnb 6 nonsyndromic hearing loss and deafness12.2
26dfnb12 nonsyndromic hearing loss and deafness12.2
27dfnb16 nonsyndromic hearing loss and deafness12.2
28dfnb18 nonsyndromic hearing loss and deafness12.2
29dfnb21 nonsyndromic hearing loss and deafness12.2
30dfnb22 nonsyndromic hearing loss and deafness12.2
31dfnb23 nonsyndromic hearing loss and deafness12.2
32dfnb24 nonsyndromic hearing loss and deafness12.2
33dfnb28 nonsyndromic hearing loss and deafness12.2
34dfnb29 nonsyndromic hearing loss and deafness12.2
35dfnb30 nonsyndromic hearing loss and deafness12.2
36dfnb35 nonsyndromic hearing loss and deafness12.2
37dfnb36 nonsyndromic hearing loss and deafness12.2
38dfnb37 nonsyndromic hearing loss and deafness12.2
39dfnb39 nonsyndromic hearing loss and deafness12.2
40dfnb49 nonsyndromic hearing loss and deafness12.2
41dfnb59 nonsyndromic hearing loss and deafness12.2
42dfnb63 nonsyndromic hearing loss and deafness12.2
43dfnb67 nonsyndromic hearing loss and deafness12.2
44dfnb77 nonsyndromic hearing loss and deafness12.2
45dfnb79 nonsyndromic hearing loss and deafness12.2
46gjb2-related dfna 3 nonsyndromic hearing loss and deafness12.2
47gjb2-related dfnb 1 nonsyndromic hearing loss and deafness12.2
48gjb6-related dfna 3 nonsyndromic hearing loss and deafness12.2
49gjb6-related dfnb 1 nonsyndromic hearing loss and deafness12.2
50nonsyndromic hearing loss and deafness, x-linked12.2

Graphical network of the top 20 diseases related to Nonsyndromic Hearing Loss and Deafness:



Diseases related to nonsyndromic hearing loss and deafness

Symptoms for Nonsyndromic Hearing Loss and Deafness

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Drugs & Therapeutics for Nonsyndromic Hearing Loss and Deafness

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Epidemiology of Non-syndromic Dominant DeafnessCompletedNCT01150305
2Non-Syndrome Hereditary Hearing Impairment - Gene Mapping: India/Pakistan ProtocolRecruitingNCT00341874
3Clinical and Genetic Analysis of Enlarged Vestibular AqueductsRecruitingNCT00023036
4Genetic Analysis of Human Hereditary Hearing ImpairmentTerminatedNCT00001606

Search NIH Clinical Center for Nonsyndromic Hearing Loss and Deafness

Genetic Tests for Nonsyndromic Hearing Loss and Deafness

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Genetic tests related to Nonsyndromic Hearing Loss and Deafness:

id Genetic test Affiliating Genes
1 Nonsyndromic Hearing Loss and Deafness23

Anatomical Context for Nonsyndromic Hearing Loss and Deafness

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Animal Models for Nonsyndromic Hearing Loss and Deafness or affiliated genes

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Publications for Nonsyndromic Hearing Loss and Deafness

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Articles related to Nonsyndromic Hearing Loss and Deafness:

idTitleAuthorsYear
1
DFNX1 Nonsyndromic Hearing Loss and Deafness (21834172)
1993
2
Nonsyndromic Hearing Loss and Deafness, DFNB1 (20301449)
1993
3
Nonsyndromic Hearing Loss and Deafness, DFNA3 (20301708)
1993
4
Nonsyndromic Hearing Loss and Deafness, Mitochondrial (20301595)
1993

Variations for Nonsyndromic Hearing Loss and Deafness

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Expression for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Search GEO for disease gene expression data for Nonsyndromic Hearing Loss and Deafness.

Pathways for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Pathways related to Nonsyndromic Hearing Loss and Deafness according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.2GJB2, GJB3, GJB6
2
Show member pathways
9.2GJB2, GJB3, GJB6
3
Show member pathways
9.2GJB2, GJB3, GJB6

GO Terms for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Cellular components related to Nonsyndromic Hearing Loss and Deafness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1connexin complexGO:00059229.5GJB2, GJB3, GJB6
2gap junctionGO:00059219.2GJB2, GJB3, GJB6

Biological processes related to Nonsyndromic Hearing Loss and Deafness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell communicationGO:00071549.8GJB3, GJB6
2inner ear developmentGO:00488399.7GJB6, POU3F4
3response to electrical stimulusGO:00516029.0GJB6, MT-CO1
4sensory perception of soundGO:00076058.8GJB2, GJB3, GJB6, POU3F4

Molecular functions related to Nonsyndromic Hearing Loss and Deafness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1gap junction channel activityGO:00052439.6GJB2, GJB3

Sources for Nonsyndromic Hearing Loss and Deafness

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet