MCID: NNS014
MIFTS: 23

Nonsyndromic Hearing Loss and Deafness malady

Genetic diseases (common), Ear diseases categories

Aliases & Classifications for Nonsyndromic Hearing Loss and Deafness

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Aliases & Descriptions for Nonsyndromic Hearing Loss and Deafness:

Name: Nonsyndromic Hearing Loss and Deafness 22 24


Classifications:



Summaries for Nonsyndromic Hearing Loss and Deafness

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MalaCards based summary: Nonsyndromic Hearing Loss and Deafness is related to nonsyndromic hearing loss and deafness, dfnb1 and nonsyndromic hearing loss and deafness, mitochondrial. An important gene associated with Nonsyndromic Hearing Loss and Deafness is GJB2 (Gap Junction Protein, Beta 2, 26kDa), and among its related pathways are Myometrial Relaxation and Contraction Pathways and Signaling in Gap Junctions.

Related Diseases for Nonsyndromic Hearing Loss and Deafness

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Diseases related to Nonsyndromic Hearing Loss and Deafness via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1nonsyndromic hearing loss and deafness, dfnb131.3GJB2, GJB6
2nonsyndromic hearing loss and deafness, mitochondrial30.8GJB2, GJB3, GJB6, POU3F4
3nonsyndromic hearing loss and deafness, autosomal dominant28.9GJB2, GJB3, GJB6, MT-CO1, MT-RNR1, MT-TS1
4dfnx1 nonsyndromic hearing loss and deafness10.8
5dfnb 7/11 nonsyndromic hearing loss and deafness10.8
6dfnb 8/10 nonsyndromic hearing loss and deafness10.7
7dfna 3 nonsyndromic hearing loss and deafness10.7
8nonsyndromic hearing loss and deafness, dfna310.6
9dfnb 1 nonsyndromic hearing loss and deafness10.6
10nonsyndromic hearing loss and deafness, autosomal recessive10.6
11dfna 1 nonsyndromic hearing loss and deafness10.6
12dfna 4 nonsyndromic hearing loss and deafness10.6
13dfna 5 nonsyndromic hearing loss and deafness10.6
14dfna 8/12 nonsyndromic hearing loss and deafness10.6
15dfna10 nonsyndromic hearing loss and deafness10.6
16dfna11 nonsyndromic hearing loss and deafness10.6
17dfna13 nonsyndromic hearing loss and deafness10.6
18dfna15 nonsyndromic hearing loss and deafness10.6
19dfna17 nonsyndromic hearing loss and deafness10.6
20dfna22 nonsyndromic hearing loss and deafness10.6
21dfna23 nonsyndromic hearing loss and deafness10.6
22dfna36 nonsyndromic hearing loss and deafness10.6
23dfna44 nonsyndromic hearing loss and deafness10.6
24dfnb 3 nonsyndromic hearing loss and deafness10.6
25dfnb 6 nonsyndromic hearing loss and deafness10.6
26dfnb12 nonsyndromic hearing loss and deafness10.6
27dfnb16 nonsyndromic hearing loss and deafness10.6
28dfnb18 nonsyndromic hearing loss and deafness10.6
29dfnb21 nonsyndromic hearing loss and deafness10.6
30dfnb22 nonsyndromic hearing loss and deafness10.6
31dfnb23 nonsyndromic hearing loss and deafness10.6
32dfnb24 nonsyndromic hearing loss and deafness10.6
33dfnb28 nonsyndromic hearing loss and deafness10.6
34dfnb29 nonsyndromic hearing loss and deafness10.6
35dfnb30 nonsyndromic hearing loss and deafness10.6
36dfnb31 nonsyndromic hearing loss and deafness10.6
37dfnb35 nonsyndromic hearing loss and deafness10.6
38dfnb36 nonsyndromic hearing loss and deafness10.6
39dfnb37 nonsyndromic hearing loss and deafness10.6
40dfnb39 nonsyndromic hearing loss and deafness10.6
41dfnb49 nonsyndromic hearing loss and deafness10.6
42dfnb59 nonsyndromic hearing loss and deafness10.6
43dfnb63 nonsyndromic hearing loss and deafness10.6
44dfnb67 nonsyndromic hearing loss and deafness10.6
45dfnb77 nonsyndromic hearing loss and deafness10.6
46dfnb79 nonsyndromic hearing loss and deafness10.6
47gjb2-related dfna 3 nonsyndromic hearing loss and deafness10.6
48gjb2-related dfnb 1 nonsyndromic hearing loss and deafness10.6
49gjb6-related dfna 3 nonsyndromic hearing loss and deafness10.6
50gjb6-related dfnb 1 nonsyndromic hearing loss and deafness10.6

Graphical network of the top 20 diseases related to Nonsyndromic Hearing Loss and Deafness:



Diseases related to nonsyndromic hearing loss and deafness

Symptoms for Nonsyndromic Hearing Loss and Deafness

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Drugs & Therapeutics for Nonsyndromic Hearing Loss and Deafness

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Epidemiology of Non-syndromic Dominant DeafnessCompletedNCT01150305
2Non-Syndrome Hereditary Hearing Impairment - Gene Mapping: India/Pakistan ProtocolRecruitingNCT00341874
3Clinical and Genetic Analysis of Enlarged Vestibular AqueductsRecruitingNCT00023036
4Genetic Analysis of Human Hereditary Hearing ImpairmentTerminatedNCT00001606

Search NIH Clinical Center for Nonsyndromic Hearing Loss and Deafness

Genetic Tests for Nonsyndromic Hearing Loss and Deafness

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Genetic tests related to Nonsyndromic Hearing Loss and Deafness:

id Genetic test Affiliating Genes
1 Nonsyndromic Hearing Loss and Deafness22 24

Anatomical Context for Nonsyndromic Hearing Loss and Deafness

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Animal Models for Nonsyndromic Hearing Loss and Deafness or affiliated genes

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Publications for Nonsyndromic Hearing Loss and Deafness

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Articles related to Nonsyndromic Hearing Loss and Deafness:

idTitleAuthorsYear
1
DFNX1 Nonsyndromic Hearing Loss and Deafness (21834172)
1993
2
Nonsyndromic Hearing Loss and Deafness, DFNB1 (20301449)
1993
3
Nonsyndromic Hearing Loss and Deafness, DFNA3 (20301708)
1993
4
Nonsyndromic Hearing Loss and Deafness, Mitochondrial (20301595)
1993

Variations for Nonsyndromic Hearing Loss and Deafness

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Expression for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Search GEO for disease gene expression data for Nonsyndromic Hearing Loss and Deafness.

Pathways for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Pathways related to Nonsyndromic Hearing Loss and Deafness according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2GJB2, GJB3, GJB6
2
Show member pathways
9.2GJB2, GJB3, GJB6
3
Show member pathways
9.2GJB2, GJB3, GJB6

GO Terms for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Cellular components related to Nonsyndromic Hearing Loss and Deafness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:00059229.4GJB2, GJB3, GJB6
2gap junctionGO:00059219.2GJB2, GJB3, GJB6

Biological processes related to Nonsyndromic Hearing Loss and Deafness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1inner ear developmentGO:00488399.7GJB6, POU3F4
2response to electrical stimulusGO:00516029.6GJB6, MT-CO1
3cell communicationGO:00071549.5GJB2, GJB3, GJB6
4sensory perception of soundGO:00076058.5GJB2, GJB3, GJB6, POU3F4

Molecular functions related to Nonsyndromic Hearing Loss and Deafness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1gap junction channel activityGO:00052439.6GJB2, GJB3

Sources for Nonsyndromic Hearing Loss and Deafness

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet