MCID: NNS014
MIFTS: 29

Nonsyndromic Hearing Loss and Deafness malady

Genetic diseases (common), Ear diseases categories

Summaries for Nonsyndromic Hearing Loss and Deafness

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34MalaCards
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MalaCards: Nonsyndromic Hearing Loss and Deafness is related to nonsyndromic hearing loss and deafness, mitochondrial and dfna 3 nonsyndromic hearing loss and deafness. An important gene associated with Nonsyndromic Hearing Loss and Deafness is GJB6 (gap junction protein, beta 6, 30kDa), and among its related pathways are Cell adhesion Gap junctions and Myometrial Relaxation and Contraction Pathways. The compounds 10panx and gap 27 have been mentioned in the context of this disorder.

Aliases & Classifications for Nonsyndromic Hearing Loss and Deafness

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21GeneTests, 23GTR
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Ear diseases


Aliases & Descriptions:

nonsyndromic hearing loss and deafness 21 23


Related Diseases for Nonsyndromic Hearing Loss and Deafness

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18GeneCards, 19GeneDecks
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Diseases related to Nonsyndromic Hearing Loss and Deafness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1nonsyndromic hearing loss and deafness, mitochondrial31.0MT-RNR1, MT-TS1
2dfna 3 nonsyndromic hearing loss and deafness30.9GJB2, GJB6
3dfnb 1 nonsyndromic hearing loss and deafness30.8GJB2, GJB6
4dfnb130.6GJB6, GJB2
5dfnx1 nonsyndromic hearing loss and deafness10.7
6nonsyndromic hearing loss and deafness, dfna310.6
7nonsyndromic hearing loss and deafness, dfnb110.6
8nonsyndromic hearing loss and deafness, autosomal dominant10.6
9nonsyndromic hearing loss and deafness, autosomal recessive10.6
10dfnb 8/10 nonsyndromic hearing loss and deafness10.6
11nonsyndromic hearing loss and deafness, x-linked10.5
12dfna 6/14/38 nonsyndromic hearing loss and deafness10.5
13gjb6-related dfna 3 nonsyndromic hearing loss and deafness10.5
14gjb6-related dfnb 1 nonsyndromic hearing loss and deafness10.5
15dfna 8/12 nonsyndromic hearing loss and deafness10.5
16dfnb21 nonsyndromic hearing loss and deafness10.5
17dfnb12 nonsyndromic hearing loss and deafness10.5
18dfna11 nonsyndromic hearing loss and deafness10.5
19dfnb 3 nonsyndromic hearing loss and deafness10.5
20dfnb 6 nonsyndromic hearing loss and deafness10.5
21dfnb 7/11 nonsyndromic hearing loss and deafness10.5
22dfnb16 nonsyndromic hearing loss and deafness10.5
23dfnb18 nonsyndromic hearing loss and deafness10.5
24dfnb28 nonsyndromic hearing loss and deafness10.5
25dfnb30 nonsyndromic hearing loss and deafness10.5
26dfna 1 nonsyndromic hearing loss and deafness10.5
27dfna 4 nonsyndromic hearing loss and deafness10.5
28dfna 5 nonsyndromic hearing loss and deafness10.5
29dfna10 nonsyndromic hearing loss and deafness10.5
30dfna13 nonsyndromic hearing loss and deafness10.5
31dfna17 nonsyndromic hearing loss and deafness10.5
32dfna22 nonsyndromic hearing loss and deafness10.5
33dfna23 nonsyndromic hearing loss and deafness10.5
34dfna36 nonsyndromic hearing loss and deafness10.5
35dfna44 nonsyndromic hearing loss and deafness10.5
36dfnb23 nonsyndromic hearing loss and deafness10.5
37dfnb31 nonsyndromic hearing loss and deafness10.5
38dfnb37 nonsyndromic hearing loss and deafness10.5
39dfnb59 nonsyndromic hearing loss and deafness10.5
40dfnb39 nonsyndromic hearing loss and deafness10.5
41dfna20/26 nonsyndromic hearing loss and deafness10.5
42dfna25 nonsyndromic hearing loss and deafness10.5
43dfna28 nonsyndromic hearing loss and deafness10.5
44dfna50 nonsyndromic hearing loss and deafness10.5
45dfna48 nonsyndromic hearing loss and deafness10.5
46dfna 2b nonsyndromic hearing loss and deafness10.5
47dfnb22 nonsyndromic hearing loss and deafness10.5
48dfnb24 nonsyndromic hearing loss and deafness10.5
49dfnb29 nonsyndromic hearing loss and deafness10.5
50dfnb36 nonsyndromic hearing loss and deafness10.5

Graphical network of the top 20 diseases related to Nonsyndromic Hearing Loss and Deafness:



Diseases related to nonsyndromic hearing loss and deafness

Symptoms for Nonsyndromic Hearing Loss and Deafness

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Drugs & Therapeutics for Nonsyndromic Hearing Loss and Deafness

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Nonsyndromic Hearing Loss and Deafness

Drug clinical trials:

Search ClinicalTrials for Nonsyndromic Hearing Loss and Deafness

Search NIH Clinical Center for Nonsyndromic Hearing Loss and Deafness

Search CenterWatch for Nonsyndromic Hearing Loss and Deafness

Genetic Tests for Nonsyndromic Hearing Loss and Deafness

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21GeneTests, 23GTR
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Genetic tests related to Nonsyndromic Hearing Loss and Deafness:

id Genetic test Affiliating Genes
1 Nonsyndromic Hearing Loss and Deafness21 23

Anatomical Context for Nonsyndromic Hearing Loss and Deafness

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Animal Models for Nonsyndromic Hearing Loss and Deafness or affiliated genes

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Publications for Nonsyndromic Hearing Loss and Deafness

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53PubMed
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Articles related to Nonsyndromic Hearing Loss and Deafness:

idTitleAuthorsYear
1
DFNX1 Nonsyndromic Hearing Loss and Deafness (21834172)
1993
2
Nonsyndromic Hearing Loss and Deafness, DFNB1 (20301449)
1993
3
Nonsyndromic Hearing Loss and Deafness, DFNA3 (20301708)
1993
4
Nonsyndromic Hearing Loss and Deafness, Mitochondrial (20301595)
1993

Variations for Nonsyndromic Hearing Loss and Deafness

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Expression for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nonsyndromic Hearing Loss and Deafness

Search GEO for disease gene expression data for Nonsyndromic Hearing Loss and Deafness.

Pathways for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 31KEGG
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Compounds for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Sources:
62Tocris Bioscience, 30IUPHAR, 25HMDB, 46Novoseek, 3BitterDB, 12DrugBank
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Compounds related to Nonsyndromic Hearing Loss and Deafness according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
110panx629.6GJB3, GJB6, GJB2
2gap 27629.6GJB6, GJB2, GJB3
3carbenoxolone disodium629.5GJB6, GJB2, GJB3
4scrambled 10panx629.5GJB6, GJB2, GJB3
5octanol30 2510.4GJB6, GJB2, GJB3
6flufenamic acid30 46 3 1212.4GJB3, GJB2, GJB6
7carbenoxolone46 30 1211.3GJB3, GJB2, GJB6
8ca2+309.1GJB6, GJB2, GJB3

GO Terms for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Sources:
17Gene Ontology
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Cellular components related to Nonsyndromic Hearing Loss and Deafness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:0059229.4GJB3, GJB2, GJB6

Biological processes related to Nonsyndromic Hearing Loss and Deafness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell communicationGO:0071549.8GJB3, GJB6
2sensory perception of soundGO:0076059.1GJB3, GJB2, GJB6

Molecular functions related to Nonsyndromic Hearing Loss and Deafness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gap junction channel activityGO:0052439.8GJB3, GJB2

Products for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nonsyndromic Hearing Loss and Deafness

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet