MCID: NNS014
MIFTS: 20

Nonsyndromic Hearing Loss and Deafness malady

Categories: Genetic diseases (common), Ear diseases

Aliases & Classifications for Nonsyndromic Hearing Loss and Deafness

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Aliases & Descriptions for Nonsyndromic Hearing Loss and Deafness:

Name: Nonsyndromic Hearing Loss and Deafness 22

Classifications:



Summaries for Nonsyndromic Hearing Loss and Deafness

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MalaCards based summary: Nonsyndromic Hearing Loss and Deafness is related to nonsyndromic hearing loss and deafness, dfnb1 and nonsyndromic hearing loss and deafness, mitochondrial. An important gene associated with Nonsyndromic Hearing Loss and Deafness is GJB2 (Gap Junction Protein Beta 2), and among its related pathways are Myometrial Relaxation and Contraction Pathways and Signaling in Gap Junctions. Affiliated tissues include liver.

Related Diseases for Nonsyndromic Hearing Loss and Deafness

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Diseases related to Nonsyndromic Hearing Loss and Deafness via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1nonsyndromic hearing loss and deafness, dfnb134.4GJB2, GJB6
2nonsyndromic hearing loss and deafness, mitochondrial33.6GJB2, GJB3, GJB6, POU3F4
3nonsyndromic hearing loss and deafness, autosomal dominant30.7GJB2, GJB3, GJB6, MT-CO1, MT-RNR1, MT-TS1
4dfnb 7/11 nonsyndromic hearing loss and deafness12.8
5dfnx1 nonsyndromic hearing loss and deafness12.7
6dfnb 8/10 nonsyndromic hearing loss and deafness12.7
7dfna 3 nonsyndromic hearing loss and deafness12.7
8dfnb 1 nonsyndromic hearing loss and deafness12.6
9nonsyndromic hearing loss and deafness, autosomal recessive12.6
10dfna 1 nonsyndromic hearing loss and deafness12.6
11dfna 4 nonsyndromic hearing loss and deafness12.6
12dfna 5 nonsyndromic hearing loss and deafness12.6
13dfna 8/12 nonsyndromic hearing loss and deafness12.6
14dfna10 nonsyndromic hearing loss and deafness12.6
15dfna11 nonsyndromic hearing loss and deafness12.6
16dfna13 nonsyndromic hearing loss and deafness12.6
17dfna15 nonsyndromic hearing loss and deafness12.6
18dfna17 nonsyndromic hearing loss and deafness12.6
19dfna22 nonsyndromic hearing loss and deafness12.6
20dfna23 nonsyndromic hearing loss and deafness12.6
21dfna36 nonsyndromic hearing loss and deafness12.6
22dfna44 nonsyndromic hearing loss and deafness12.6
23dfnb 3 nonsyndromic hearing loss and deafness12.6
24dfnb 6 nonsyndromic hearing loss and deafness12.6
25dfnb12 nonsyndromic hearing loss and deafness12.6
26dfnb16 nonsyndromic hearing loss and deafness12.6
27dfnb18 nonsyndromic hearing loss and deafness12.6
28dfnb21 nonsyndromic hearing loss and deafness12.6
29dfnb22 nonsyndromic hearing loss and deafness12.6
30dfnb23 nonsyndromic hearing loss and deafness12.6
31dfnb24 nonsyndromic hearing loss and deafness12.6
32dfnb28 nonsyndromic hearing loss and deafness12.6
33dfnb29 nonsyndromic hearing loss and deafness12.6
34dfnb30 nonsyndromic hearing loss and deafness12.6
35dfnb31 nonsyndromic hearing loss and deafness12.6
36dfnb35 nonsyndromic hearing loss and deafness12.6
37dfnb36 nonsyndromic hearing loss and deafness12.6
38dfnb37 nonsyndromic hearing loss and deafness12.6
39dfnb39 nonsyndromic hearing loss and deafness12.6
40dfnb49 nonsyndromic hearing loss and deafness12.6
41dfnb59 nonsyndromic hearing loss and deafness12.6
42dfnb63 nonsyndromic hearing loss and deafness12.6
43dfnb67 nonsyndromic hearing loss and deafness12.6
44dfnb77 nonsyndromic hearing loss and deafness12.6
45dfnb79 nonsyndromic hearing loss and deafness12.6
46gjb2-related dfna 3 nonsyndromic hearing loss and deafness12.6
47gjb2-related dfnb 1 nonsyndromic hearing loss and deafness12.6
48gjb6-related dfna 3 nonsyndromic hearing loss and deafness12.6
49gjb6-related dfnb 1 nonsyndromic hearing loss and deafness12.6
50nonsyndromic hearing loss and deafness, dfna312.6

Graphical network of the top 20 diseases related to Nonsyndromic Hearing Loss and Deafness:



Diseases related to nonsyndromic hearing loss and deafness

Symptoms for Nonsyndromic Hearing Loss and Deafness

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Drugs & Therapeutics for Nonsyndromic Hearing Loss and Deafness

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Epidemiology of Non-syndromic Dominant DeafnessCompletedNCT01150305
2Non-Syndrome Hereditary Hearing Impairment - Gene Mapping: India/Pakistan ProtocolRecruitingNCT00341874
3Clinical and Genetic Analysis of Enlarged Vestibular AqueductsRecruitingNCT00023036
4Genetic Analysis of Human Hereditary Hearing ImpairmentTerminatedNCT00001606

Search NIH Clinical Center for Nonsyndromic Hearing Loss and Deafness

Genetic Tests for Nonsyndromic Hearing Loss and Deafness

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Genetic tests related to Nonsyndromic Hearing Loss and Deafness:

id Genetic test Affiliating Genes
1 Nonsyndromic Hearing Loss and Deafness22

Anatomical Context for Nonsyndromic Hearing Loss and Deafness

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MalaCards organs/tissues related to Nonsyndromic Hearing Loss and Deafness:

33
Liver

Animal Models for Nonsyndromic Hearing Loss and Deafness or affiliated genes

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Publications for Nonsyndromic Hearing Loss and Deafness

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Articles related to Nonsyndromic Hearing Loss and Deafness:

idTitleAuthorsYear
1
Ganciclovir therapy for congenital cytomegalovirus infection in six infants. (16148844)
2005
2
Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. (15976031)
2005
3
Potential human neurotoxicity of MDMA ('Ecstasy'): subjective self-reports, evidence from an Italian drug addiction centre and clinical case studies. (10867553)
2000
4
Major central nervous system malformation in "micromelic dwarfism with cone epiphyses, metaphyseal dysplasia and vertebral segmentation defects". (8986289)
1997

Variations for Nonsyndromic Hearing Loss and Deafness

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Expression for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Search GEO for disease gene expression data for Nonsyndromic Hearing Loss and Deafness.

Pathways for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Pathways related to Nonsyndromic Hearing Loss and Deafness according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.2GJB2, GJB3, GJB6
2
Show member pathways
9.2GJB2, GJB3, GJB6
3
Show member pathways
9.2GJB2, GJB3, GJB6

GO Terms for genes affiliated with Nonsyndromic Hearing Loss and Deafness

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Biological processes related to Nonsyndromic Hearing Loss and Deafness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell communicationGO:000715410.1GJB2, GJB6
2sensory perception of soundGO:00076059.2GJB2, GJB3, GJB6

Sources for Nonsyndromic Hearing Loss and Deafness

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet