MCID: NNT010
MIFTS: 34

Nontoxic Goiter malady

Category: Endocrine diseases

Aliases & Classifications for Nontoxic Goiter

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Aliases & Descriptions for Nontoxic Goiter:

Name: Nontoxic Goiter 11 50 13 68
Nodule-Thyroid, Non Tox 11
Non-Toxic Simple Goitre 11
 
Goiter, Non-Toxic Nos 11
Goitre, Non-Toxic Nos 11
Non-Toxic Goitre 11

Classifications:



External Ids:

Disease Ontology11 DOID:13195
NCIt45 C35271

Summaries for Nontoxic Goiter

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MalaCards based summary: Nontoxic Goiter, also known as nodule-thyroid, non tox, is related to goiter and thyroiditis. An important gene associated with Nontoxic Goiter is TG (Thyroglobulin), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Insulin secretion. Affiliated tissues include thyroid, bone and testes, and related mouse phenotype Increased shRNA abundance (Z-score > 2).

Related Diseases for Nontoxic Goiter

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Diseases related to Nontoxic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1goiter10.7
2thyroiditis10.5
3iatrogenic or traumatic pituitary deficiency10.4TG, TPO
4ovarian endometrioid cystadenoma10.4TG, TPO
5rhabdomyosarcoma, embryonal, 210.4TG, TPO
6peripheral scars of retina10.4TG, TPO
7chronic frontal sinusitis10.4TG, TPO
8ovarian cystic teratoma10.3BGLAP, TG
9hypothryoidism, congenital, nongoitrous 410.3TG, TPO
10mononeuritis of upper limb10.3BGLAP, TPO
11tinea corporis10.3SERPINA7, TG
12dysautonomia, familial10.3TG, TPO
13deafness, autosomal recessive 4, with enlarged vestibular aqueduct10.3TG, TPO
14demyelinating polyneuropathy10.2TG, TSHR
15malignant syringoma10.2TG, TSHR
16acquired central diabetes insipidus10.2TG, TSHR
17benign mesothelioma10.2TG, TSHR
18glaucomatocyclitic crisis10.2TG, TSHR
19graves' disease10.1
20deep angioma10.1CALCA, TG
21acute thyroiditis10.1CALCA, TG
22pleomorphic adenoma10.1CALCA, TG
23mixed endometrial stromal and smooth muscle tumor10.1CALCA, TG
24norwegian scabies10.0CALCA, TG
25lung cancer susceptibility 210.0BGLAP, SHBG
26bone lymphoma10.0CALCA, TG
27parathyroid transitional clear cell adenoma10.0BGLAP, CALCA
28capillariasis10.0BGLAP, CALCA
29lung occult adenocarcinoma10.0SERPINA7, SHBG, TG
30dyscalculia10.0BGLAP, CALCA
31bacillary angiomatosis10.0BGLAP, CALCA
32angelucci's syndrome10.0BGLAP, CALCA
33acquired hyperkeratosis10.0BGLAP, CALCA
34scrotal carcinoma10.0BGLAP, CALCA
35mild pre-eclampsia9.9BGLAP, CALCA
36acute salpingo-oophoritis9.9BGLAP, CALCA
37allergic conjunctivitis9.9BGLAP, CALCA
38crohn's disease of the esophagus9.9TG, TPO, TSHR
39physical disorder9.9BGLAP, CALCA
40meckel's diverticulum9.9CALCA, TPO
41primary bacterial infectious disease9.9TG, TPO, TSHR
42bone deterioration disease9.9BGLAP, CALCA
43blood group incompatibility9.9TG, TPO, TSHR
44intermittent proptosis9.9TG, TPO, TSHR
45dysgraphia9.9CALCA, TG
46leukodystrophy9.9BGLAP, CALCA
47respiratory failure9.8
48myxedema9.8
49thyroid cancer9.8
50cervicitis9.8

Graphical network of the top 20 diseases related to Nontoxic Goiter:



Diseases related to nontoxic goiter

Symptoms & Phenotypes for Nontoxic Goiter

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GenomeRNAi Phenotypes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-359.2BGLAP, SHBG, TPO

Drugs & Therapeutics for Nontoxic Goiter

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Drugs for Nontoxic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Salmon Calcitoninapproved, investigationalPhase 29147931-85-116129616
Synonyms:
135506-95-5
47931-85-1
Astronin
Biocalcin
Bionocalcin
C028815
C06865
C145H239N43O48S2
CALCITONIN, SALMON
Cadens
Calciben
Calcihexal
Calcimar
Calcimar (TN)
Calcimonta
Calcinil
Calcioton
Calcitonin (Salmon Synthetic)
Calcitonin (salmon)
Calcitonin 1 precursor
Calcitonin Salmon
Calcitonin [USAN:INN:BAN:JAN]
Calcitonin salmon
Calcitonin salmon (USAN/INN)
Calcitonin salmon (synthesis)
Calcitonin salmon (synthesis) (JAN)
Calcitonin salmon recombinant
Calcitonin vom lachs
Calcitonin, salmar
Calcitonin, salmon
Calcitonin, salmon, for bioassay
Calcitonin,salmon
Calcitonin-salmon
Calcitonina
Calcitonine de saumon
Calcitoran
Calco
Calogen
Calsynar
Calsynar Lyo L
Caltine
Casalm
Catonin
Cibacalcin
Cibacalcine
Citonina
 
D00249
EINECS 256-342-8
Eptacalcin
Forcaltonin
Fortical
Fortical (TN)
Ipocalcin
Isi-calcin
Kalsimin
Karil
LS-48624
Miacalcic
Miacalcin
Miacalcin (TN)
Miracalcic
Oseototal
Osseocalcina
Osteobion
Osteovis
Ostosalm
Ostostabil
Porostenina
Prontocalcin
Quosten
Riostin
Rulicalcin
Salcat
Salcatonin
Salcatyn
Salmocalcin
Salmofar
Salmon calcitonin
Salmon calcitonin I
Salmon calcitonin-(I-32)
Salmotonin
Sical
Stalcin
Staporos
Steocin
TZ-CT
Thyrocalcitonin (salmon)
Tonocalcin
UNII-7SFC6U2VI5
Ucecal
recombinant salmon calcitonin
salmon calcitonin (1-32)
synthetic salmon calcitonin
2Calcitonin Gene-Related PeptidePhase 291
3calcitoninPhase 2103
4Bone Density Conservation AgentsPhase 23266

Interventional clinical trials:

idNameStatusNCT IDPhase
1rhTSH, Thyroid Size, and Radioiodine Therapy in Benign GoiterCompletedNCT00145366Phase 2
2rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular GoiterCompletedNCT00275171Phase 2
3ThyrOp: A Study of Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic GoiterUnknown statusNCT01358136
4Outcomes of Different Thyroid Resections for Multinodular Non-toxic GoiterCompletedNCT00946894
5Changes in Quality of Life Following Surgical Treatment of Benign Non-toxic GoiterActive, not recruitingNCT02651818
6Goitres Influence on Voice Function - The Impact of SurgeryActive, not recruitingNCT02468921

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Genetic Tests for Nontoxic Goiter

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Anatomical Context for Nontoxic Goiter

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MalaCards organs/tissues related to Nontoxic Goiter:

36
Thyroid, Bone, Testes

Publications for Nontoxic Goiter

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Articles related to Nontoxic Goiter:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Total Thyroidectomy versus Bilateral Subtotal Thyroidectomy for Bilateral Multinodular Nontoxic Goiter: A Meta-Analysis. (27256349)
2016
2
Quality of life in patients with benign nontoxic goiter: impact of disease and treatment response, and comparison with the general population. (25602312)
2015
3
Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter. (24482635)
2014
4
Incidental thyroid cancer in toxic and nontoxic goiter: Is TSH associated with malignanCy rate? Results of a meta-analysis. (23186976)
2013
5
Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter. (22577172)
2012
6
Acute respiratory failure caused by neglected giant substernal nontoxic goiter. (21655873)
2011
7
Total thyroidectomy: is morbidity higher for Graves' disease than nontoxic goiter? (21550063)
2011
8
Five-year follow-up of a randomized clinical trial of total thyroidectomy versus Dunhill operation versus bilateral subtotal thyroidectomy for multinodular nontoxic goiter. (20174803)
2010
9
Does unilateral lobectomy suffice to manage unilateral nontoxic goiter? (19703811)
2010
10
Radioiodine treatment of Plummer and multinodular toxic and nontoxic goiter disease by the first approximation dosimetry method. (17600473)
2007
11
Metastasis as presenting feature of thyroid follicular carcinoma; report of a patient thyroidectomized for benign multinodular nontoxic goiter. (16029132)
2005
12
A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. (11238476)
2001
13
Evaluation and treatment of sporadic nontoxic goiter--some answers and more questions. (11238475)
2001
14
Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. (10690902)
2000
15
Tc-99m MDP thyroid uptake in a patient with a large nontoxic goiter. (11079599)
2000
16
The effect of iodine administration on the development of thyroid autoimmunity in patients with nontoxic goiter. (10907993)
2000
17
Is routine thyroxine treatment to hinder postoperative recurrence of nontoxic goiter justified? (10022449)
1999
18
Postural changes of the cervical spine in patients with nontoxic goiter. (9868630)
1998
19
Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. (9284721)
1997
20
Iodine-131 therapy in sporadic nontoxic goiter. (9074521)
1997
21
Long-term observation of serum thyroglobulin after resection of nontoxic goiter and relation to ultrasonographically demonstrated relapse. (8661844)
1996
22
Improvement of upper airway obstruction after 131I-treatment of multinodular nontoxic goiter evaluated by flow volume loop curves. (8778168)
1996
23
Radioiodine uptake as a function of stored iodine and thyroglobulin in thyroid follicles: in vitro quantitative imaging approach with secondary ion mass spectrometry (SIMS) microscopy in human nontoxic goiter. (7920005)
1994
24
Superior vena cava syndrome due to a substernal nontoxic goiter. (8004873)
1994
25
Bone metabolism in premenopausal women with nontoxic goiter and reduced serum thyrotropin levels. (7536445)
1994
26
Thyroid hormone suppressive therapy of sporadic nontoxic goiter. (1422239)
1992
27
Determinants of outcome in sporadic nontoxic goiter. (1284332)
1992
28
Hypervascularity of nontoxic goiter as shown by color-coded Doppler sonography. (1772472)
1991
29
Bone Gla protein and sex hormone-binding globulin in nontoxic goiter: parameters for metabolic status at the tissue level. (2294139)
1990
30
Interrelationships between age, thyroid volume, thyroid nodularity, and thyroid function in patients with sporadic nontoxic goiter. (2239979)
1990
31
Transforming growth factor beta regulates thyroid growth. Role in the pathogenesis of nontoxic goiter. (2921318)
1989
32
Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease. (3130398)
1988
33
Increased thyroidal T4/T3 ratio in nodular and paranodular tissues of nontoxic goiter following suppressive treatment with thyroid hormones. (3570153)
1987
34
Serum thyroglobulin concentration in nontoxic goiter and response to surgery with special reference to risk of goiter relapse. (3092474)
1986
35
Triiodothyronine suppression of diffuse nontoxic goiter. (6470438)
1984
36
Seasonal variation of stable intrathyroidal iodine in nontoxic goiter disclosed by x-ray fluorescence. (7096913)
1982
37
Serum thyroglobulin in patients undergoing subtotal thyroidectomy for toxic and nontoxic goiter. (7108151)
1982
38
Thyroid blood flow rate in man. Electromagnetic flowmetry during operation in euthyroid normal gland, nontoxic goiter, and hyperthyroidism. (6459360)
1981
39
Endemic and sporadic nontoxic goiter. (7033981)
1981
40
Thyroid uptake on bone scan in a large, multinodular, nontoxic goiter with calcific degeneration. (7438651)
1980
41
Thyroglobulin and calcitonin in patients with nontoxic goiter. (702754)
1978
42
Different sensitivity of 131I uptake and TRH test during thyroxine treatment of nontoxic goiter. (122399)
1978
43
Increased serum thyroglobulin levels in patients with nontoxic goiter. (755050)
1978
44
Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification defect. (1165726)
1975
45
Serum triiodothyronine in simple nontoxic goiter in Sicily. (1213666)
1975
46
Nontoxic goiter-diffuse or nodular. (1174255)
1975
47
Suppressive therapy of nontoxic goiter. (4432862)
1974
48
Thyrotropin response to synthetic thyrotropin-releasing hormone in normal subjects and in patients with nontoxic goiter. (4115461)
1972
49
TSH production rate in nontoxic goiter. (5577165)
1971
50
Defective intrathyroidal iodine metabolism in nontoxic goiter: inadequate iodination of thyroglobulin. (5679994)
1968

Variations for Nontoxic Goiter

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Expression for genes affiliated with Nontoxic Goiter

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Search GEO for disease gene expression data for Nontoxic Goiter.

Pathways for genes affiliated with Nontoxic Goiter

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GO Terms for genes affiliated with Nontoxic Goiter

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Cellular components related to Nontoxic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.2BGLAP, CALCA, FASLG, SERPINA7, SHBG, TG
2extracellular spaceGO:00056157.5BGLAP, CALCA, FASLG, SERPINA7, TG, TPO

Biological processes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:004244610.0TG, TPO
2thyroid hormone generationGO:00065909.7TG, TPO
3activation of adenylate cyclase activityGO:00071909.5CALCA, TSHR
4adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.4CALCA, TSHR

Sources for Nontoxic Goiter

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet