MCID: NNT010
MIFTS: 44

Nontoxic Goiter malady

Endocrine diseases category
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Summaries for Nontoxic Goiter

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33MalaCards
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MalaCards: Nontoxic Goiter, also known as nodule-thyroid, non tox, is related to goiter and thyroiditis. An important gene associated with Nontoxic Goiter is BGLAP (bone gamma-carboxyglutamate (gla) protein), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Insulin secretion. The compounds triiodothyroacetic acid and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Nontoxic Goiter

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

nontoxic goiter 8 45 62
nodule-thyroid, non tox 8
non-toxic simple goitre 8
goitre, non-toxic nos 8
goiter, non-toxic nos 8
non-toxic goitre 8


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Disease Ontology8 DOID:13195
NCIt40 C35271
ICD1025 E04.8

Related Diseases for Nontoxic Goiter

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17GeneCards, 18GeneDecks
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Diseases related to Nontoxic Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.5BGLAP, TPO, TG, TSHR
2thyroiditis31.1TSHR, FASLG, TG, TPO
3graves' disease30.5BGLAP, TPO, TG, FASLG, TSHR
4myxedema30.3TPO, TG, TSHR
5thyrotoxicosis30.3TPO, TG, TSHR
6hyperthyroidism30.2TSHR, TG, TPO, BGLAP
7thyroid cancer30.2TSHR, TG, TPO, BGLAP
8thyroxine-binding globulin deficiency10.2
9cervicitis10.2
10respiratory failure10.2
11superior vena cava syndrome10.2
12blindness10.2
13subacute thyroiditis10.1TG
14pernicious anemia10.0TPO, TG
15plummer's disease10.0TG, TPO
16thyrotropin deficiency, isolated10.0TPO, TG
17autoimmune thyroiditis10.0TG, TPO
18pendred syndrome10.0TPO, TG
19thyroid agenesis10.0TG, TSHR
20pregnancy loss10.0TG, TPO
21struma ovarii10.0TSHR, TG
22hyperthyroxinemia10.0TSHR, TPO
23follicular thyroid carcinoma10.0TSHR, TG
24addison's disease10.0TPO, TG
25celiac disease10.0TG, TPO
26turner syndrome10.0BGLAP, TPO, TG
27down syndrome10.0TSHR, TPO
28type 1 diabetes mellitus10.0TPO, FASLG
29toxic diffuse goiter10.0TSHR, TG, TPO
30endemic goiter10.0TPO, TG, TSHR
31multinodular goiter10.0TSHR, TG, TPO
32nodular goiter10.0TSHR, TG, TPO
33congenital hypothyroidism10.0TSHR, TG, TPO
34thyroid adenoma10.0TSHR, TG, TPO
35thyroid cancer, anaplastic10.0TSHR, TG, TPO
36follicular adenoma10.0TSHR, TG, TPO
37papillary carcinoma10.0TPO, TG, TSHR
38papillary thyroid carcinoma10.0TSHR, TG, TPO
39hypothyroidism10.0TPO, TG, TSHR
40viral hepatitis10.0TSHR, FASLG
41sjogren's syndrome9.9TSHR, FASLG
42adenoma9.9TSHR, TG, TPO
43osteosarcoma9.9BGLAP, FASLG, TSHR
44systemic lupus erythematosus9.9TPO, FASLG, TSHR
45hypersensitivity reaction type ii disease9.9TSHR, FASLG

Graphical network of the top 20 diseases related to Nontoxic Goiter:



Diseases related to nontoxic goiter

Symptoms for Nontoxic Goiter

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Drugs & Therapeutics for Nontoxic Goiter

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Nontoxic Goiter

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Anatomical Context for Nontoxic Goiter

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33MalaCards
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MalaCards organs/tissues related to Nontoxic Goiter:

33
Thyroid, Bone, Testes

Animal Models for Nontoxic Goiter or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Nontoxic Goiter:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0TSHR, FASLG, TG, TPO
2MP:00053797.9TSHR, FASLG, TG, TPO
3MP:00053977.7TPO, TG, FASLG, TSHR

Publications for Nontoxic Goiter

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52PubMed
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Articles related to Nontoxic Goiter:

(show top 50)    (show all 59)
idTitleAuthorsYear
1
Incidental thyroid cancer in toxic and nontoxic goiter: Is TSH associated with malignanCy rate? Results of a meta-analysis. (23186976)
2013
2
Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter. (22577172)
2012
3
Total thyroidectomy: is morbidity higher for Graves' disease than nontoxic goiter? (21550063)
2011
4
Acute respiratory failure caused by neglected giant substernal nontoxic goiter. (21655873)
2011
5
Radioiodine treatment of Plummer and multinodular toxic and nontoxic goiter disease by the first approximation dosimetry method. (17600473)
2007
6
Metastasis as presenting feature of thyroid follicular carcinoma; report of a patient thyroidectomized for benign multinodular nontoxic goiter. (16029132)
2005
7
Evaluation and treatment of sporadic nontoxic goiter--some answers and more questions. (11238475)
2001
8
A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. (11238476)
2001
9
Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. (10690902)
2000
10
Tc-99m MDP thyroid uptake in a patient with a large nontoxic goiter. (11079599)
2000
11
Postural changes of the cervical spine in patients with nontoxic goiter. (9868630)
1998
12
Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. (9284721)
1997
13
Long-term observation of serum thyroglobulin after resection of nontoxic goiter and relation to ultrasonographically demonstrated relapse. (8661844)
1996
14
Improvement of upper airway obstruction after 131I-treatment of multinodular nontoxic goiter evaluated by flow volume loop curves. (8778168)
1996
15
Superior vena cava syndrome due to a substernal nontoxic goiter. (8004873)
1994
16
Bone metabolism in premenopausal women with nontoxic goiter and reduced serum thyrotropin levels. (7536445)
1994
17
Determinants of outcome in sporadic nontoxic goiter. (1284332)
1992
18
Thyroid hormone suppressive therapy of sporadic nontoxic goiter. (1422239)
1992
19
Bone Gla protein and sex hormone-binding globulin in nontoxic goiter: parameters for metabolic status at the tissue level. (2294139)
1990
20
Interrelationships between age, thyroid volume, thyroid nodularity, and thyroid function in patients with sporadic nontoxic goiter. (2239979)
1990
21
Transforming growth factor beta regulates thyroid growth. Role in the pathogenesis of nontoxic goiter. (2921318)
1989
22
Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease. (3130398)
1988
23
Increased thyroidal T4/T3 ratio in nodular and paranodular tissues of nontoxic goiter following suppressive treatment with thyroid hormones. (3570153)
1987
24
Serum thyroglobulin concentration in nontoxic goiter and response to surgery with special reference to risk of goiter relapse. (3092474)
1986
25
Triiodothyronine suppression of diffuse nontoxic goiter. (6470438)
1984
26
Seasonal variation of stable intrathyroidal iodine in nontoxic goiter disclosed by x-ray fluorescence. (7096913)
1982
27
Serum thyroglobulin in patients undergoing subtotal thyroidectomy for toxic and nontoxic goiter. (7108151)
1982
28
Endemic and sporadic nontoxic goiter. (7033981)
1981
29
Thyroid blood flow rate in man. Electromagnetic flowmetry during operation in euthyroid normal gland, nontoxic goiter, and hyperthyroidism. (6459360)
1981
30
Thyroid uptake on bone scan in a large, multinodular, nontoxic goiter with calcific degeneration. (7438651)
1980
31
Different sensitivity of 131I uptake and TRH test during thyroxine treatment of nontoxic goiter. (122399)
1978
32
Increased serum thyroglobulin levels in patients with nontoxic goiter. (755050)
1978
33
Thyroglobulin and calcitonin in patients with nontoxic goiter. (702754)
1978
34
Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification defect. (1165726)
1975
35
Nontoxic goiter-diffuse or nodular. (1174255)
1975
36
Serum triiodothyronine in simple nontoxic goiter in Sicily. (1213666)
1975
37
Suppressive therapy of nontoxic goiter. (4432862)
1974
38
Thyrotropin response to synthetic thyrotropin-releasing hormone in normal subjects and in patients with nontoxic goiter. (4115461)
1972
39
TSH production rate in nontoxic goiter. (5577165)
1971
40
Defective intrathyroidal iodine metabolism in nontoxic goiter: inadequate iodination of thyroglobulin. (5679994)
1968
41
The salivary iodide trap in nontoxic goiter. (5635445)
1968
42
DYNAMIC DISTURBANCES OF INTRATHYROID IODINE METABOLISM IN SPORADIC NONTOXIC GOITER. (14167072)
1964
43
Treatment of nontoxic goiter with sodium liothyronine. A double-blind study. (13966033)
1963
44
ABNORMAL IODOPROTEIN IN NONTOXIC GOITER. (14052265)
1963
45
System of radioiodine therapy for thyrotoxicosis and nontoxic goiter involving measurement of thyroidal radiosensitivity. (13727257)
1961
46
Nontoxic goiter. (13812866)
1960
47
Clinical-pathologic study of 76 cases of recurrent Graves' disease, toxic (non-exophthalmic) goiter, and nontoxic goiter; does a relation exist between thyroid hyperplasia and struma lymphomatosa? (13424488)
1957
48
Congenital, hereditary, diffuse nontoxic goiter as a cause of persistent face presentation. (13080366)
1953
49
The effects of L-thyroxine sodium on nontoxic goiter, on myxedema and on the thyroid uptake of radioactive iodine. (13002643)
1952
50
Some surgical problems of nontoxic goiter. (14778880)
1950

Variations for Nontoxic Goiter

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Expression for genes affiliated with Nontoxic Goiter

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nontoxic Goiter

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Pathways for genes affiliated with Nontoxic Goiter

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50PathCards, 60Thomson Reuters, 30KEGG, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN
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Compounds for genes affiliated with Nontoxic Goiter

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45Novoseek, 24HMDB, 51PharmGKB, 29IUPHAR, 11DrugBank, 3BitterDB, 61Tocris Bioscience
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Compounds related to Nontoxic Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1triiodothyroacetic acid459.9BGLAP, TG
2iodotyrosine45 2410.8TG, TPO
3diiodotyrosine459.8TG, TPO
4perchlorate459.8TPO, TG
5gliadin459.7TPO, TG
6amiodarone45 51 29 1112.7TPO, TG
7amino acid459.6TPO, TSHR
8cardiolipin45 1110.6TG, TPO
9maltose45 1110.6TPO, TSHR
10atpo29 4510.5TPO, FASLG
11hydrocortisone45 3 61 1112.3TPO, TG, BGLAP
12carbimazole45 1110.3TSHR, TPO, BGLAP
13sodium iodide459.3TPO, TSHR, TG
14prednisolone45 29 1111.3BGLAP, TG, TSHR
15propylthiouracil45 3 1111.3TSHR, TG, TPO
16iodine45 2410.2TG, TSHR, TPO
17nitrate459.2FASLG, TPO
18125i459.2TSHR, TG, TPO
19iodide45 2410.2TSHR, TG, TPO
20triiodothyronine459.2TSHR, TG, TPO
21ribonucleic acid459.1TPO, TSHR, TG
22tetracycline45 1110.1BGLAP, FASLG, TPO
23chromium459.0TG, TPO, FASLG
24gold459.0TG, FASLG, TPO
25creatinine459.0TG, TPO, BGLAP
26cyclosporin a45 29 6110.9FASLG, TG, BGLAP
27agarose458.9FASLG, TPO, TSHR
28depsipeptide458.8FASLG, TG
29genistein45 29 61 3 24 1113.8TPO, TG, FASLG
30estradiol45 24 1110.8FASLG, BGLAP, TSHR
31methimazole45 3 1110.8TSHR, TG, BGLAP, TPO
32thyroxine45 249.8TG, BGLAP, TSHR, TPO
33sodium45 249.7TPO, TG, TSHR
34arginine458.7TPO, BGLAP, TG, TSHR
35cisplatin45 51 61 1111.7TG, FASLG, BGLAP
36thymidine45 249.6TSHR, FASLG, TG
37ascorbic acid45 249.6FASLG, TG, BGLAP, TPO
38h2o2458.5BGLAP, TG, TPO, FASLG
39testosterone45 61 24 1111.5TPO, BGLAP, FASLG, TG
40paraffin458.5BGLAP, TG, TSHR, FASLG
41polysaccharide458.4TG, TPO, FASLG, TSHR
42vegf458.4TG, BGLAP, TSHR, FASLG
43alanine458.4BGLAP, TSHR, FASLG, TG
44adenylate458.4TSHR, TPO, FASLG, TG
45estrogen458.4BGLAP, TSHR, FASLG, TG
46glutamate458.3TPO, TG, FASLG, TSHR
47serine458.2FASLG, TSHR, BGLAP, TG
48aspartate458.0BGLAP, TG, FASLG, TSHR, TPO
49retinoic acid45 249.0TSHR, FASLG, TG, BGLAP, TPO
50cysteine458.0FASLG, TPO, BGLAP, TG, TSHR

GO Terms for genes affiliated with Nontoxic Goiter

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16Gene Ontology
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Cellular components related to Nontoxic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.5TSHR, FASLG, TPO
2extracellular spaceGO:0056157.9FASLG, TG, TPO, BGLAP

Biological processes related to Nontoxic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:0065909.4TG, TPO
2hormone biosynthetic processGO:0424469.1TG, TPO

Products for genes affiliated with Nontoxic Goiter

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Sources for Nontoxic Goiter

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet