MCID: NNT010
MIFTS: 31

Nontoxic Goiter malady

Endocrine diseases category

Aliases & Classifications for Nontoxic Goiter

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Sources:
10Disease Ontology, 47Novoseek, 65UMLS, 59SNOMED-CT, 42NCIt, 27ICD10
See all sources

Aliases & Descriptions for Nontoxic Goiter:

Name: Nontoxic Goiter 10 47 65
Nodule-Thyroid, Non Tox 10
Non-Toxic Simple Goitre 10
 
Goiter, Non-Toxic Nos 10
Goitre, Non-Toxic Nos 10
Non-Toxic Goitre 10


Classifications:



External Ids:

Disease Ontology10 DOID:13195
NCIt42 C35271
ICD1027 E04.8

Summaries for Nontoxic Goiter

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MalaCards based summary: Nontoxic Goiter, also known as nodule-thyroid, non tox, is related to thyroiditis and thyroid gland disease. An important gene associated with Nontoxic Goiter is TG (Thyroglobulin), and among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Thyroxine (Thyroid Hormone) Production. Affiliated tissues include thyroid, testes and bone.

Related Diseases for Nontoxic Goiter

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Diseases related to Nontoxic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.5CALCA, TG
2thyroid gland disease29.8CALCA, TG, TPO, TSHR
3goiter11.1
4graves' disease10.5
5cervicitis10.2
6hyperthyroidism10.2
7hypothyroidism10.2
8respiratory failure10.2
9thyroid cancer10.2
10mitochondrial disorders10.2
11superior vena cava syndrome10.2
12thyroxine-binding globulin deficiency10.2
13autoimmune thyroiditis10.2TG, TPO
14intraneural perineurioma10.2CALCA, TG
15rhabdomyosarcoma, embryonal, 210.2TG, TPO
16thyroid ectopia10.2TG, TPO
17selective iga deficiency disease10.2CALCA, TG
18riedel's fibrosing thyroiditis10.2CALCA, TG
19uterine corpus adenofibroma10.2CALCA, TG
20methemoglobinemia10.1TG, TPO
21hypothryoidism, congenital, nongoitrous 410.1TG, TPO
22waldeyer's ring cancer10.1BGLAP, CALCA
23neurofibrosarcoma10.1TG, TPO
24vulvar apocrine adenocarcinoma10.1CALCA, TG
25bone inflammation disease10.1BGLAP, CALCA
26glaucoma, primary open angle, juvenile-onset, 210.1TG, TPO
27mucolipidosis10.1BGLAP, CALCA
28duane retraction syndrome10.1BGLAP, CALCA
29pulmonary type ovarian small cell carcinoma10.1BGLAP, CALCA
30marcus gunn phenomenon10.1BGLAP, CALCA
31prostatic cyst10.1BGLAP, CALCA
32candidiasis10.1BGLAP, CALCA
33parietal lobe neoplasm10.1BGLAP, CALCA
34hereditary elliptocytosis10.1BGLAP, CALCA
35pendred syndrome10.1TG, TPO
36worth's syndrome10.1BGLAP, CALCA
37hemoglobinopathy10.1BGLAP, CALCA
38neuroectodermal tumor10.1BGLAP, CALCA
39bone structure disease10.1BGLAP, CALCA
40facial neuralgia10.1BGLAP, CALCA
41pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.1CALCA, TPO
42gingival disease10.1BGLAP, CALCA
43junctional epidermolysis bullosa10.1CALCA, TG
44medullary thyroid carcinoma, familial10.0CALCA, TG
45adult central nervous system germinoma10.0TG, TSHR
46iatrogenic or traumatic pituitary deficiency10.0TG, TSHR
47subcutaneous mycosis10.0TG, TSHR
48hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.0TG, TSHR
49schwannoma of jugular foramen10.0BGLAP, CALCA
50gonococcal iridocyclitis10.0TG, TSHR

Graphical network of the top 20 diseases related to Nontoxic Goiter:



Diseases related to nontoxic goiter

Symptoms for Nontoxic Goiter

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Drugs & Therapeutics for Nontoxic Goiter

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Interventional clinical trials:

idNameStatusNCT IDPhase
1rhTSH, Thyroid Size, and Radioiodine Therapy in Benign GoiterCompletedNCT00145366Phase 2
2rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular GoiterCompletedNCT00275171Phase 2
3Outcomes of Different Thyroid Resections for Multinodular Non-toxic GoiterCompletedNCT00946894
4Changes in Quality of Life Following Surgical Treatment of Benign Non-toxic GoiterRecruitingNCT02651818
5ThyrOp: A Study of Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic GoiterRecruitingNCT01358136
6Goitres Influence on Voice Function - The Impact of SurgeryRecruitingNCT02468921

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Genetic Tests for Nontoxic Goiter

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Anatomical Context for Nontoxic Goiter

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MalaCards organs/tissues related to Nontoxic Goiter:

33
Thyroid, Testes, Bone

Animal Models for Nontoxic Goiter or affiliated genes

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Publications for Nontoxic Goiter

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Articles related to Nontoxic Goiter:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
Quality of life in patients with benign nontoxic goiter: impact of disease and treatment response, and comparison with the general population. (25602312)
2015
2
Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter. (24482635)
2014
3
Incidental thyroid cancer in toxic and nontoxic goiter: Is TSH associated with malignanCy rate? Results of a meta-analysis. (23186976)
2013
4
Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter. (22577172)
2012
5
Total thyroidectomy: is morbidity higher for Graves' disease than nontoxic goiter? (21550063)
2011
6
Acute respiratory failure caused by neglected giant substernal nontoxic goiter. (21655873)
2011
7
Radioiodine treatment of Plummer and multinodular toxic and nontoxic goiter disease by the first approximation dosimetry method. (17600473)
2007
8
Metastasis as presenting feature of thyroid follicular carcinoma; report of a patient thyroidectomized for benign multinodular nontoxic goiter. (16029132)
2005
9
Evaluation and treatment of sporadic nontoxic goiter--some answers and more questions. (11238475)
2001
10
A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. (11238476)
2001
11
Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. (10690902)
2000
12
Tc-99m MDP thyroid uptake in a patient with a large nontoxic goiter. (11079599)
2000
13
Postural changes of the cervical spine in patients with nontoxic goiter. (9868630)
1998
14
Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. (9284721)
1997
15
Long-term observation of serum thyroglobulin after resection of nontoxic goiter and relation to ultrasonographically demonstrated relapse. (8661844)
1996
16
Improvement of upper airway obstruction after 131I-treatment of multinodular nontoxic goiter evaluated by flow volume loop curves. (8778168)
1996
17
Superior vena cava syndrome due to a substernal nontoxic goiter. (8004873)
1994
18
Bone metabolism in premenopausal women with nontoxic goiter and reduced serum thyrotropin levels. (7536445)
1994
19
Determinants of outcome in sporadic nontoxic goiter. (1284332)
1992
20
Bone Gla protein and sex hormone-binding globulin in nontoxic goiter: parameters for metabolic status at the tissue level. (2294139)
1990
21
Interrelationships between age, thyroid volume, thyroid nodularity, and thyroid function in patients with sporadic nontoxic goiter. (2239979)
1990
22
Transforming growth factor beta regulates thyroid growth. Role in the pathogenesis of nontoxic goiter. (2921318)
1989
23
Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease. (3130398)
1988
24
Increased thyroidal T4/T3 ratio in nodular and paranodular tissues of nontoxic goiter following suppressive treatment with thyroid hormones. (3570153)
1987
25
Serum thyroglobulin concentration in nontoxic goiter and response to surgery with special reference to risk of goiter relapse. (3092474)
1986
26
Triiodothyronine suppression of diffuse nontoxic goiter. (6470438)
1984
27
Seasonal variation of stable intrathyroidal iodine in nontoxic goiter disclosed by x-ray fluorescence. (7096913)
1982
28
Serum thyroglobulin in patients undergoing subtotal thyroidectomy for toxic and nontoxic goiter. (7108151)
1982
29
Endemic and sporadic nontoxic goiter. (7033981)
1981
30
Thyroid blood flow rate in man. Electromagnetic flowmetry during operation in euthyroid normal gland, nontoxic goiter, and hyperthyroidism. (6459360)
1981
31
Thyroid uptake on bone scan in a large, multinodular, nontoxic goiter with calcific degeneration. (7438651)
1980
32
Different sensitivity of 131I uptake and TRH test during thyroxine treatment of nontoxic goiter. (122399)
1978
33
Increased serum thyroglobulin levels in patients with nontoxic goiter. (755050)
1978
34
Thyroglobulin and calcitonin in patients with nontoxic goiter. (702754)
1978
35
Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification defect. (1165726)
1975
36
Nontoxic goiter-diffuse or nodular. (1174255)
1975
37
Serum triiodothyronine in simple nontoxic goiter in Sicily. (1213666)
1975
38
Suppressive therapy of nontoxic goiter. (4432862)
1974
39
Thyrotropin response to synthetic thyrotropin-releasing hormone in normal subjects and in patients with nontoxic goiter. (4115461)
1972
40
TSH production rate in nontoxic goiter. (5577165)
1971
41
Defective intrathyroidal iodine metabolism in nontoxic goiter: inadequate iodination of thyroglobulin. (5679994)
1968
42
DYNAMIC DISTURBANCES OF INTRATHYROID IODINE METABOLISM IN SPORADIC NONTOXIC GOITER. (14167072)
1964
43
Treatment of nontoxic goiter with sodium liothyronine. A double-blind study. (13966033)
1963
44
ABNORMAL IODOPROTEIN IN NONTOXIC GOITER. (14052265)
1963
45
The thiocyanate suppression test--a new and simple test for differential diagnosis between hyperthyrodism and nontoxic goiter. (14496764)
1962
46
System of radioiodine therapy for thyrotoxicosis and nontoxic goiter involving measurement of thyroidal radiosensitivity. (13727257)
1961
47
Nontoxic goiter. (13812866)
1960
48
Clinical-pathologic study of 76 cases of recurrent Graves' disease, toxic (non-exophthalmic) goiter, and nontoxic goiter; does a relation exist between thyroid hyperplasia and struma lymphomatosa? (13424488)
1957
49
Congenital, hereditary, diffuse nontoxic goiter as a cause of persistent face presentation. (13080366)
1953
50
Some surgical problems of nontoxic goiter. (14778880)
1950

Variations for Nontoxic Goiter

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Expression for genes affiliated with Nontoxic Goiter

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Search GEO for disease gene expression data for Nontoxic Goiter.

Pathways for genes affiliated with Nontoxic Goiter

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GO Terms for genes affiliated with Nontoxic Goiter

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Cellular components related to Nontoxic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1BGLAP, CALCA, FASLG, TG, TPO
2extracellular regionGO:00055767.7BGLAP, CALCA, FASLG, SHBG, TG

Biological processes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:00424469.6TG, TPO
2adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.3CALCA, TSHR
3activation of adenylate cyclase activityGO:00071909.3CALCA, TSHR
4cell-cell signalingGO:00072678.4CALCA, FASLG, TSHR

Molecular functions related to Nontoxic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051029.0CALCA, FASLG, TG

Sources for Nontoxic Goiter

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet