MCID: NNT010
MIFTS: 41

Nontoxic Goiter malady

Endocrine category

Summaries for Nontoxic Goiter

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33MalaCards
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MalaCards: Nontoxic Goiter, also known as nodule-thyroid, non tox, is related to multinodular goiter and graves' disease. An important gene associated with Nontoxic Goiter is TG (thyroglobulin), and among its related pathways are Insulin secretion and Allograft rejection. The compounds propylthiouracil and chromium have been mentioned in the context of this disorder. Affiliated tissues include thyroid, salivary gland and t cells, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Classifications for Nontoxic Goiter

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

nontoxic goiter 8 45 61
nodule-thyroid, non tox 8
non-toxic simple goitre 8
goitre, non-toxic nos 8
goiter, non-toxic nos 8
non-toxic goitre 8


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Disease Ontology8 DOID:13195
NCIt40 C35271
ICD1025 E04.8

Related Diseases for Nontoxic Goiter

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Nontoxic Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1multinodular goiter30.8TSHR, TPO, TG
2graves' disease30.7BGLAP, FASLG, TSHR, TPO, TG
3nodular goiter30.6TG, TPO, TSHR
4thyroiditis30.2FASLG, TRH, TSHR, TPO, TG
5endemic goiter30.2TSHR, TPO, TG
6myxedema30.2TSHR, TPO, TG
7thyroid cancer30.2TSHR, TPO, TG
8thyrotoxicosis30.2TRH, TSHR, TPO, TG
9substernal goiter10.3
10thyroxine-binding globulin deficiency10.2
11thyroid lymphoma10.2
12n syndrome10.2
13superior vena cava syndrome10.2
14graves disease 110.2
15subacute thyroiditis10.0TG
16diabetes insipidus10.0TRH
17endogenous depression10.0TRH
18deficiency anemia10.0TRH
19neonatal thyrotoxicosis10.0TSHR
20vitiligo10.0TPO
21hyperprolactinemia10.0TRH
22obesity10.0TRH
23diabetes mellitus10.0BGLAP
24celiac disease10.0TPO, TG
25addison's disease10.0TG, TPO
26pernicious anemia10.0TG, TPO
27autoimmune thyroiditis10.0TPO, TG
28amenorrhea10.0TRH
29arthritis10.0BGLAP
30plummer's disease10.0TPO, TG
31hepatitis10.0FASLG
32thyrotropin deficiency, isolated10.0TG, TPO
33pseudohypoparathyroidism10.0BGLAP
34thyroid hormone resistance syndrome10.0TRH, TG
35pendred syndrome10.0TG, TPO
36thyroid agenesis10.0TSHR, TG
37struma ovarii10.0TSHR, TG
38pregnancy loss10.0TG, TPO
39follicular thyroid carcinoma10.0TSHR, TG
40hypoparathyroidism10.0BGLAP
41down syndrome10.0TPO, TSHR
42exophthalmos10.0TSHR, TRH
43viral hepatitis10.0FASLG, TSHR
44type 1 diabetes10.0FASLG, TPO
45prolactinoma10.0TRH
46cholera10.0TSHR, TRH
47thyroid adenoma10.0TG, TPO, TSHR
48toxic diffuse goiter10.0TG, TPO, TSHR
49congenital hypothyroidism10.0TSHR, TPO, TG
50thyroid cancer, anaplastic10.0TG, TPO, TSHR

Graphical network of the top 20 diseases related to Nontoxic Goiter:



Diseases related to nontoxic goiter

Clinical Features for Nontoxic Goiter

Drugs & Therapeutics for Nontoxic Goiter

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Nontoxic Goiter

Search CenterWatch for Nontoxic Goiter

Genetic Tests for Nontoxic Goiter

Anatomical Context for Nontoxic Goiter

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33MalaCards
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MalaCards organs/tissues related to Nontoxic Goiter:

33
Thyroid, Salivary gland, T cells, B cells, Endothelial

Animal Models for Nontoxic Goiter or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Nontoxic Goiter:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.6TG, TSHR, FASLG
2MP:00053767.9TG, TPO, TSHR, TRH, FASLG

Publications for Nontoxic Goiter

Sources:
51PubMed
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Articles related to Nontoxic Goiter:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter. (22577172)
2012
2
Approach to the patient with nontoxic multinodular goiter. (21543434)
2011
3
Total thyroidectomy: is morbidity higher for Graves' disease than nontoxic goiter? (21550063)
2011
4
Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study. (19403877)
2009
5
Radioiodine treatment of Plummer and multinodular toxic and nontoxic goiter disease by the first approximation dosimetry method. (17600473)
2007
6
Transient goiter enlargement after administration of 0.3 mg of recombinant human thyrotropin in patients with benign nontoxic nodular goiter: a randomized, double-blind, crossover trial. (16434453)
2006
7
Safety and efficacy of administering 0.2 mg of recombinant human TSH for two consecutive days as an adjuvant to therapy with low radioiodine doses in elderly out-patients with large nontoxic multinodular goiter. (17213787)
2006
8
Ultrasound-guided laser thermal ablation in the treatment of autonomous hyperfunctioning thyroid nodules and compressive nontoxic nodular goiter. (14611703)
2003
9
Management of the nontoxic multinodular goiter: a North American survey. (11788632)
2002
10
Administration of a single low dose of recombinant human thyrotropin significantly enhances thyroid radioiodide uptake in nontoxic nodular goiter. (11061507)
2000
11
Therapeutic options in the management of toxic and nontoxic nodular goiter. (10787189)
2000
12
Radioiodine treatment for nontoxic multinodular goiter. (10450683)
1999
13
Postural changes of the cervical spine in patients with nontoxic goiter. (9868630)
1998
14
Radioiodine for nontoxic multinodular goiter. (9133693)
1997
15
Familial nontoxic multinodular thyroid goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer. (9345104)
1997
16
Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. (9284721)
1997
17
Diffuse nontoxic and multinodular goiter. (9174716)
1997
18
Preoperative localization of a parathyroid adenoma with Tc-99m sestamibi imaging in a patient with concomitant nontoxic multinodular goiter. (7895432)
1995
19
Superior vena cava syndrome due to a substernal nontoxic goiter. (8004873)
1994
20
Diffuse nontoxic and multinodular goiter. (7704811)
1994
21
Determinants of outcome in sporadic nontoxic goiter. (1284332)
1992
22
Hypervascularity of nontoxic goiter as shown by color-coded Doppler sonography. (1772472)
1991
23
Bone Gla protein and sex hormone-binding globulin in nontoxic goiter: parameters for metabolic status at the tissue level. (2294139)
1990
24
Nontoxic nodular goiter and papillary thyroid carcinoma are not associated with peripheral blood lymphocyte sensitization to thyroid cells. (2462573)
1989
25
Sequential changes in serum thyroglobulin, triiodothyronine, and thyroxine following partial thyroidectomy for nontoxic nodular goiter. (3386534)
1988
26
Studies on T and B lymphocytes by the technique of immune and non-immune rosettes and by scanning electron microscopy (SEM) in Graves' disease and nontoxic nodular goiter. (6607508)
1983
27
Seasonal variation of stable intrathyroidal iodine in nontoxic goiter disclosed by x-ray fluorescence. (7096913)
1982
28
Thyroid blood flow rate in man. Electromagnetic flowmetry during operation in euthyroid normal gland, nontoxic goiter, and hyperthyroidism. (6459360)
1981
29
Thyroglobulin and calcitonin in patients with nontoxic goiter. (702754)
1978
30
Suppressive therapy of nontoxic goiter. (4432862)
1974
31
Nontoxic nodular goiter (adenomatous goiter). (4423281)
1974
32
Thyrotropin response to synthetic thyrotropin-releasing hormone in normal subjects and in patients with nontoxic goiter. (4115461)
1972
33
Defective intrathyroidal iodine metabolism in nontoxic goiter: inadequate iodination of thyroglobulin. (5679994)
1968
34
Nontoxic nodular goiter and carcinoma of the thyroid in children 15 years of age and younger. (6022975)
1967
35
Treatment of nontoxic goiter with sodium liothyronine. A double-blind study. (13966033)
1963
36
ABNORMAL IODOPROTEIN IN NONTOXIC GOITER. (14052265)
1963
37
Nontoxic goiter. (13812866)
1960
38
Nontoxic nodular goiter with formation and release of a compound with the chromatographic mobility characteristics of triiodothyronine. (13784480)
1960
39
Surgical indications in nontoxic nodular goiter; a controversial problem. (13648442)
1959
40
Cardiac complications in patients with nontoxic and toxic nodular goiter and with Graves' disease. (13588186)
1958
41
Clinical-pathologic study of 76 cases of recurrent Graves' disease, toxic (non-exophthalmic) goiter, and nontoxic goiter; does a relation exist between thyroid hyperplasia and struma lymphomatosa? (13424488)
1957
42
A chromatographic study of thyroidal iodine metabolism in nontoxic nodular goiter. (13475471)
1957
43
A long-term follow-up of nontoxic nodular goiter; effect of clinical selection on the observed incidence of malignancy. (13393835)
1957
44
Nontoxic goiter. (13427432)
1957
45
The dilemma of the nontoxic nodular goiter. (13363172)
1956
46
Incidence of malignancy in toxic and nontoxic nodular goiter. (13151843)
1954
47
The effects of L-thyroxine sodium on nontoxic goiter, on myxedema and on the thyroid uptake of radioactive iodine. (13002643)
1952
48
Carcinoma of the thyroid and nontoxic nodular goiter. (14922102)
1952
49
Therapeutic problems of nontoxic nodular goiter. (18147526)
1949
50
Clinical differentiation of various types of nontoxic nodular goiter. (18120036)
1949

Genetic Variations for Nontoxic Goiter

Expression for genes affiliated with Nontoxic Goiter

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nontoxic Goiter

Search GEO for disease gene expression data for Nontoxic Goiter.

Pathways for genes affiliated with Nontoxic Goiter

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30KEGG, 12EMD Millipore
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Pathways related to Nontoxic Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6TG, TPO
2
Hide members
9.1TG, TPO, TSHR
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.0FASLG, BGLAP

Compounds for genes affiliated with Nontoxic Goiter

Sources:
45Novoseek, 2BitterDB, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Nontoxic Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1propylthiouracil45 2 1112.5TG
2chromium4510.4TPO
3iodotyrosine45 2411.0TG, TPO
4diiodotyrosine4510.0TPO, TG
5perchlorate4510.0TG, TPO
6gliadin459.8TG, TPO
7amino acid459.7TSHR, TPO
8atpo45 2910.7FASLG, TPO
9cycloheximide459.7TRH, FASLG
10maltose45 1110.6TPO, TSHR
11triiodothyroacetic acid459.6BGLAP, TG
12amiodarone45 50 29 1112.6TG, TPO
13cardiolipin45 1110.6TG, TPO
14sodium iodide459.5TSHR, TPO, TG
15125i459.5TG, TPO, TSHR
16iodide45 2410.5TSHR, TPO, TG
17gold459.3TG, TPO, FASLG
18acth459.2TPO, TSHR, TRH
19glutaraldehyde459.2TG, TRH
20ribonucleic acid459.2TG, TPO, TSHR
21agarose459.2FASLG, TSHR, TPO
22carbimazole45 1110.1TPO, TSHR, BGLAP
23prednisolone45 29 1111.1BGLAP, TSHR, TG
24iodine45 2410.0TRH, TSHR, TPO, TG
25triiodothyronine459.0TRH, TSHR, TPO, TG
26acetylcholine45 50 29 11 2413.0TRH, TPO, TG
27tetracycline45 119.9TPO, FASLG, BGLAP
28polysaccharide458.9TG, TPO, TSHR, FASLG
29cysteine458.8TG, TPO, TSHR, FASLG
30thymidine45 249.8FASLG, TRH, TSHR, TG
31gnrh458.7TRH, FASLG, BGLAP
32hydrocortisone45 2 60 1111.7TG, TPO, TRH, BGLAP
33oligonucleotide458.6FASLG, TRH, TSHR, TPO
34ascorbic acid45 249.6BGLAP, FASLG, TPO, TG
35h2o2458.5TG, TPO, FASLG, BGLAP
36paraffin458.5BGLAP, FASLG, TSHR, TG
37adenylate458.4FASLG, TRH, TSHR, TPO, TG
38estradiol45 11 2410.4BGLAP, FASLG, TRH, TSHR
39vegf458.4BGLAP, FASLG, TSHR, TG
40glutamate458.3FASLG, TRH, TSHR, TPO, TG
41alanine458.3BGLAP, FASLG, TSHR, TG
42tyrosine458.2FASLG, TRH, TSHR, TPO, TG
43methimazole45 2 1110.2TG, TPO, TSHR, TRH, BGLAP
44thyroxine45 249.2BGLAP, TRH, TSHR, TPO, TG
45arginine458.2BGLAP, TRH, TSHR, TPO, TG
46aspartate458.1BGLAP, FASLG, TSHR, TPO, TG
47testosterone45 60 11 2411.1BGLAP, FASLG, TRH, TPO, TG
48retinoic acid45 249.0BGLAP, FASLG, TSHR, TPO, TG
49estrogen458.0TG, TSHR, TRH, FASLG, BGLAP
50calcium45 50 11 2410.6BGLAP, FASLG, TRH, TSHR, TPO

GO Terms for genes affiliated with Nontoxic Goiter

Sources:
16Gene Ontology
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Cellular components related to Nontoxic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1TG, TRH, FASLG, BGLAP

Biological processes related to Nontoxic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.6TG, TPO
2thyroid hormone generationGO:0065909.5TG, TPO
3response to ethanolGO:0454719.1TRH, BGLAP
4cell-cell signalingGO:0072678.5TSHR, TRH, FASLG

Products for genes affiliated with Nontoxic Goiter

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Sources for Nontoxic Goiter

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet