Nontoxic Goiter malady

MalaCards: Nontoxic Goiter, also known as goiter, non-toxic nos (disorder), is related to multinodular goiter and pendred syndrome. An important gene associated with Nontoxic Goiter is TG (thyroglobulin), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs methimazole and thyroid and the compounds triiodothyroacetic acid and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related mouse phenotype endocrine/exocrine gland.

Aliases & Descriptions:

nontoxic goiter 6 8 32 43 goiter, non-toxic nos (disorder) 6 non-toxic simple goitre 6 nodule-thyroid, non tox 6

goitre, non-toxic nos 6 non-toxic goitre 6 goiter 43

Diseases related to nontoxic goiter by text searches and GeneDecks gene sharing:

(show top 50)    (show all 124)

id	Related Disease	Score	Top Affiliating Genes
1	multinodular goiter	32.6	TG, TSHR, TPO, TRH
2	pendred syndrome	32.4	TG, TPO
3	nodular goiter	31.9	TPO, TSHR, TG
4	endemic goiter	31.1	TRH, TPO, TSHR, TG
5	plummer's disease	30.8	TPO, TG
6	hypothyroidism	30.5	TG, TSHR, TPO, TRH, BGLAP
7	goiter	30.0	TG, TSHR, TPO, TRH, FASLG, BGLAP
8	toxic diffuse goiter	29.6	TG, TSHR, TPO
9	thyroid cancer	29.6	TPO, TSHR, TG
10	thyroid carcinoma	29.0	BGLAP, FASLG, TSHR
11	thyroiditis	28.6	TG, TSHR, TPO, TRH, FASLG, BGLAP
12	autoimmune thyroiditis	28.2	TG, TSHR, TPO, FASLG
13	carcinoma	28.2	TG, TSHR, TPO, TRH, FASLG, BGLAP
14	congenital hypothyroidism	27.3	TG, TSHR, TPO, BGLAP
15	papillary thyroid carcinoma	27.1	TPO, TSHR, TG
16	follicular adenoma	26.9	TPO, TG
17	adenoma	26.7	TG, TSHR, TPO, TRH, FASLG, BGLAP
18	graves' disease	26.5	TG, TSHR, TPO, TRH, FASLG, BGLAP
19	thyroid adenoma	25.7	TG, TSHR, TPO, TRH, BGLAP
20	hyperthyroidism	24.9	TG, TSHR, TPO, TRH, FASLG, BGLAP
21	thyroid hormone resistance syndrome	13.0	TG, TRH
22	gonadal dysgenesis	13.0	BGLAP, TG
23	total iodide organification defect	12.9	TPO, TG
24	iodine hypothyroidism	12.9	TPO, TG
25	hashimoto's encephalitis	12.9	TPO, TG
26	myelomeningocele	12.9	TRH, BGLAP
27	megaloblastic anemia	12.9	TG, TPO
28	premature menopause	12.9	TG, TPO
29	adrenal gland hyperfunction	12.9	BGLAP, TRH
30	parathyroid adenoma	12.9	BGLAP, TG
31	adult-onset still's disease	12.9	TG, FASLG
32	thyrotropin deficiency, isolated	12.9	TPO, TG
33	pseudohypoparathyroidism	12.9	BGLAP, TRH
34	limbic encephalitis	12.9	TG, TPO
35	mccune albright syndrome	12.9	TRH, BGLAP
36	autoimmune polyendocrine syndrome	12.9	TPO, TG
37	thyroid hormone metabolism	12.9	TG, TPO
38	sycp3-related pregnancy loss, susceptibility to	12.8	TPO, TG
39	atrophy of thyroid	12.8	TRH, TPO
40	hyperprolactinemia	12.8	BGLAP, TRH
41	rickets	12.8	BGLAP, TPO
42	hypoparathyroidism	12.7	BGLAP, TPO
43	thyroid agenesis	12.7	TG, TSHR
44	struma ovarii	12.7	TG, TSHR
45	cushing's syndrome	12.7	TRH, BGLAP
46	thyroid cancer, follicular	12.7	TSHR, TG
47	mumps	12.7	TPO, TG
48	amenorrhea	12.7	TRH, BGLAP
49	neonatal thyrotoxicosis	12.6	TRH, TSHR
50	acromegaly	12.6	TG, TRH, BGLAP

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 levothyroxine, levothyroxine sodium, liothyronine, liothyronine sodium, methimazole, propylthiouracil, thyroglobulin, thyroid, thyroid pwdr [va product], thyroid,bovine

MalaCards organs/tissues related to nontoxic goiter:

²²

MGI Mouse Phenotypes related to nontoxic goiter:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	7.6	FASLG, TRH, TPO, TSHR, TG

Articles related to nontoxic goiter:

id	Title	Authors	Year	Affiliating Genes
1	Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. (10690902)	Schuppert F.... Kohn L.D.	2000	TPO, TG
2	The effect of iodine administration on the developmen t of thyroid autoimmunity in patients with nontoxic goiter. (10907993)	Papanastasiou L.... Koutras D.A.	2000	TG
3	Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. (9284721)	Nygaard B.... Hansen J.E.	1997	TSHR, TG
4	Long-term observation of serum thyroglobulin after resection of nontoxic goiter and relation to ultrasonographically demonstrated relapse. (8661844)	Date J.... Graversen H.P.	1996	TG
5	Radioiodine uptake as a function of stored iodine and thyroglobulin in thyroid follicles: in vitro quantitative imaging approach with secondary ion mass spectrometry (SIMS) microscopy in human nontoxic goiter. (7920005)	Fragu P.... Jeusset J.	1994	TG
6	Bone Gla protein and sex hormone-binding globulin in nontoxic goiter: parameters for metabolic status at the tissue level. (2294139)	Faber J.... Johansen J.S.	1990	BGLAP

Genes related to nontoxic goiter according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	TG	thyroglobulin	11.0	Publications
2	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
3	TSHR	thyroid stimulating hormone receptor	11.0	Publications
4	TPO	thyroid peroxidase	11.0	Publications
5	FASLG	Fas ligand (TNF superfamily, member 6)	11.0
6	TRH	thyrotropin-releasing hormone	11.0

Pathways related to nontoxic goiter according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.2	BGLAP, FASLG
2	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.9	BGLAP, FASLG
3	Autoimmune thyroid disease20	8.0	FASLG, TPO, TSHR, TG

Compounds related to nontoxic goiter according to GeneDecks:

(show top 50)    (show all 65)

id	Compound	Score	Top Affiliating Genes
1	triiodothyroacetic acid32	10.0	BGLAP, TG
2	iodotyrosine32 18	10.9	TPO, TG
3	diiodotyrosine32	9.8	TPO, TG
4	perchlorate32	9.8	TPO, TG
5	gliadin32	9.7	TPO, TG
6	amino acid32	9.6	TPO, TSHR
7	glutaraldehyde32	9.6	TRH, TG
8	amiodarone32 9 9	11.6	TG, TPO
9	maltose32 9 9	11.5	TPO, TSHR
10	prednisolone32 9 9	11.4	TG, TSHR, BGLAP
11	atpo32	9.4	FASLG, TPO
12	sodium iodide32	9.4	TPO, TSHR, TG
13	propylthiouracil32 9 9	11.4	TG, TSHR, TPO
14	gnrh32	9.4	FASLG, TRH
15	125i32	9.3	TPO, TSHR, TG
16	iodide32 18	10.3	TG, TSHR, TPO
17	carbimazole32 9 9	11.3	BGLAP, TPO, TSHR
18	cardiolipin32 9 9	11.1	TPO, TG
19	acth32	9.1	TSHR, TPO, TRH
20	ribonucleic acid32	9.1	TPO, TSHR, TG
21	chromium32	9.1	FASLG, TPO, TG
22	nitrate32	9.0	FASLG, TPO
23	gold32	9.0	FASLG, TPO, TG
24	tetracycline32 9 9	10.9	TPO, FASLG, BGLAP
25	acetylcholine32 9 18 9	11.9	TG, TPO, TRH
26	hydrocortisone32 9 9	10.9	TG, TPO, TRH, BGLAP
27	iodine32 18	9.9	TG, TSHR, TPO, TRH
28	triiodothyronine32	8.8	TG, TSHR, TPO, TRH
29	agarose32	8.8	TSHR, TPO, FASLG
30	paraffin32	8.6	BGLAP, FASLG, TSHR, TG
31	ascorbic acid32 18	9.6	TG, TPO, FASLG, BGLAP
32	thymidine32 18	9.6	TG, TSHR, TRH, FASLG
33	estradiol32 9 18 9	11.5	TSHR, TRH, FASLG, BGLAP
34	vegf32	8.5	TG, TSHR, FASLG, BGLAP
35	polysaccharide32	8.5	TG, TSHR, TPO, FASLG
36	h2o232	8.5	BGLAP, FASLG, TPO, TG
37	alanine32	8.4	TG, TSHR, FASLG, BGLAP
38	cycloheximide32	8.4	FASLG, TRH, TPO, TG
39	methimazole32 9 9	10.4	BGLAP, TRH, TPO, TSHR, TG
40	thyroxine32 18	9.4	TG, TSHR, TPO, TRH, BGLAP
41	arginine32	8.4	TG, TSHR, TPO, TRH, BGLAP
42	oligonucleotide32	8.3	TSHR, TPO, TRH, FASLG
43	estrogen32	8.1	TG, TSHR, TRH, FASLG, BGLAP
44	aspartate32	8.1	TG, TSHR, TPO, FASLG, BGLAP
45	testosterone32 9 18 9	11.1	TG, TPO, TRH, FASLG, BGLAP
46	retinoic acid32 42 18	10.0	BGLAP, FASLG, TPO, TSHR, TG
47	cysteine32	8.0	TG, TSHR, TPO, FASLG, BGLAP
48	adenylate32	8.0	TG, TSHR, TPO, TRH, FASLG
49	tyrosine32	7.8	TG, TSHR, TPO, TRH, FASLG
50	calcium32 9 18 9	10.4	TSHR, TPO, TRH, FASLG, BGLAP

Biological processes related to nontoxic goiter according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone biosynthetic process	GO:042446	9.1	TPO, TG
2	cell-cell signaling	GO:007267	8.6	FASLG, TRH, TSHR