MCID: NNT010
MIFTS: 35

Nontoxic Goiter malady

Categories: Endocrine diseases

Aliases & Classifications for Nontoxic Goiter

Aliases & Descriptions for Nontoxic Goiter:

Name: Nontoxic Goiter 12 52 14 69
Nodule-Thyroid, Non Tox 12
Non-Toxic Simple Goitre 12
Goiter, Non-Toxic Nos 12
Goitre, Non-Toxic Nos 12
Non-Toxic Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13195
NCIt 47 C35271
UMLS 69 C0221777

Summaries for Nontoxic Goiter

MalaCards based summary : Nontoxic Goiter, also known as nodule-thyroid, non tox, is related to goiter and thyroiditis. An important gene associated with Nontoxic Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Allograft rejection and Insulin secretion. The drugs Salmon Calcitonin and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and bone, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Nontoxic Goiter

Diseases related to Nontoxic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Related Disease Score Top Affiliating Genes
1 goiter 10.7
2 thyroiditis 10.5
3 fibrous meningioma 10.2 TG TPO
4 premature closure of the arterial duct 10.2 TG TPO
5 frontal sinusitis 10.2 TG TPO
6 caudal regression syndrome 10.2 TG TPO
7 acute hemorrhagic encephalitis 10.2 TG TSHR
8 color blindness 10.2 TG TPO
9 mesocardia 10.2 TG TSHR
10 dysautonomia, familial 10.2 TG TPO
11 echinostomiasis 10.2 SERPINA7 TG
12 parachordoma 10.2 TG TSHR
13 acute laryngitis 10.1 TG TSHR
14 graves' disease 10.1
15 congenital nonspherocytic hemolytic anemia 10.1 SERPINA7 TPO
16 dihydrolipoamide dehydrogenase deficiency 10.1 TG TPO
17 endophthalmitis 10.1 CALCA TG
18 corneal ectasia 10.1 CALCA TG
19 superior vena cava angiosarcoma 10.1 CALCA TG
20 tick paralysis 10.1 SHBG TG TPO
21 perineural angioma 10.1 CALCA TG
22 parietal lobe neoplasm 10.1 CALCA TG
23 adult ependymoblastoma 10.1 BGLAP CALCA
24 hypophosphatasia, adult 10.1 BGLAP CALCA
25 mesenchymal cell neoplasm 10.0 BGLAP CALCA
26 childhood vagina botryoid rhabdomyosarcoma 10.0 CALCA TG
27 cowden syndrome 3 10.0 CALCA TG
28 maroteaux stanescu cousin syndrome 10.0 BGLAP CALCA
29 retroperitoneal sarcoma 10.0 FASLG SHBG
30 neuhauser daly magnelli syndrome 10.0 TG TPO TSHR
31 acrorenal syndrome 10.0 BGLAP CALCA
32 conjunctival deposit 10.0 TG TPO TSHR
33 phacolytic glaucoma 10.0 BGLAP CALCA
34 denys-drash syndrome 10.0 TG TPO TSHR
35 commensal bacterial infectious disease 10.0 TG TPO TSHR
36 pes anserinus tendinitis or bursitis 10.0 BGLAP CALCA
37 choreoathetosis, hypothyroidism, and neonatal respiratory distress 10.0 TG TPO TSHR
38 articulation disorder 10.0 TG TPO TSHR
39 bizarre leiomyoma 10.0 CALCA TG
40 tinea unguium 10.0 BGLAP CALCA
41 neuronopathy, distal hereditary motor, type viia 10.0 SERPINA7 TG TSHR
42 opioid abuse 10.0 BGLAP CALCA
43 salpingo-oophoritis 10.0 BGLAP CALCA
44 axial osteomalacia 10.0 BGLAP CALCA
45 chronic eosinophilic pneumonia 10.0 CALCA TPO
46 pre-eclampsia 10.0 BGLAP CALCA
47 parathyroid carcinoma 10.0 BGLAP CALCA
48 childhood teratocarcinoma of the testis 9.9 CALCA TG
49 hypogonadism cardiomyopathy 9.9 CALCA SHBG TG
50 dysbaric osteonecrosis 9.9 BGLAP CALCA

Graphical network of the top 20 diseases related to Nontoxic Goiter:



Diseases related to Nontoxic Goiter

Symptoms & Phenotypes for Nontoxic Goiter

GenomeRNAi Phenotypes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.6 BGLAP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.6 BGLAP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.6 BGLAP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.6 TPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.6 BGLAP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.6 BGLAP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.6 BGLAP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.6 BGLAP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.6 TPO BGLAP SHBG
10 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.6 BGLAP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.6 SHBG
12 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.6 TPO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.6 SHBG
14 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.6 SHBG
15 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.6 TPO
16 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.6 TPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-69 9.6 SHBG

Drugs & Therapeutics for Nontoxic Goiter

Drugs for Nontoxic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salmon Calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
2 Bone Density Conservation Agents Phase 2
3 calcitonin Phase 2
4 Calcitonin Gene-Related Peptide Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2
2 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2
3 ThyrOp: A Study of Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter Unknown status NCT01358136
4 Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter Completed NCT00946894
5 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Recruiting NCT03091140
6 Changes in Quality of Life Following Surgical Treatment of Benign Non-toxic Goiter Active, not recruiting NCT02651818
7 Goitres Influence on Voice Function - The Impact of Surgery Active, not recruiting NCT02468921

Search NIH Clinical Center for Nontoxic Goiter

Genetic Tests for Nontoxic Goiter

Anatomical Context for Nontoxic Goiter

MalaCards organs/tissues related to Nontoxic Goiter:

39
Thyroid, Testes, Bone

Publications for Nontoxic Goiter

Articles related to Nontoxic Goiter:

(show top 50) (show all 63)
id Title Authors Year
1
Total Thyroidectomy versus Bilateral Subtotal Thyroidectomy for Bilateral Multinodular Nontoxic Goiter: A Meta-Analysis. ( 27256349 )
2016
2
Quality of life in patients with benign nontoxic goiter: impact of disease and treatment response, and comparison with the general population. ( 25602312 )
2015
3
Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter. ( 24482635 )
2014
4
Incidental thyroid cancer in toxic and nontoxic goiter: Is TSH associated with malignanCy rate? Results of a meta-analysis. ( 23186976 )
2013
5
Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter. ( 22577172 )
2012
6
Total thyroidectomy: is morbidity higher for Graves' disease than nontoxic goiter? ( 21550063 )
2011
7
Acute respiratory failure caused by neglected giant substernal nontoxic goiter. ( 21655873 )
2011
8
Five-year follow-up of a randomized clinical trial of total thyroidectomy versus Dunhill operation versus bilateral subtotal thyroidectomy for multinodular nontoxic goiter. ( 20174803 )
2010
9
Does unilateral lobectomy suffice to manage unilateral nontoxic goiter? ( 19703811 )
2010
10
Radioiodine treatment of Plummer and multinodular toxic and nontoxic goiter disease by the first approximation dosimetry method. ( 17600473 )
2007
11
Metastasis as presenting feature of thyroid follicular carcinoma; report of a patient thyroidectomized for benign multinodular nontoxic goiter. ( 16029132 )
2005
12
Evaluation and treatment of sporadic nontoxic goiter--some answers and more questions. ( 11238475 )
2001
13
A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. ( 11238476 )
2001
14
Tc-99m MDP thyroid uptake in a patient with a large nontoxic goiter. ( 11079599 )
2000
15
The effect of iodine administration on the development of thyroid autoimmunity in patients with nontoxic goiter. ( 10907993 )
2000
16
Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. ( 10690902 )
2000
17
Is routine thyroxine treatment to hinder postoperative recurrence of nontoxic goiter justified? ( 10022449 )
1999
18
Postural changes of the cervical spine in patients with nontoxic goiter. ( 9868630 )
1998
19
Iodine-131 therapy in sporadic nontoxic goiter. ( 9074521 )
1997
20
Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. ( 9284721 )
1997
21
Long-term observation of serum thyroglobulin after resection of nontoxic goiter and relation to ultrasonographically demonstrated relapse. ( 8661844 )
1996
22
Improvement of upper airway obstruction after 131I-treatment of multinodular nontoxic goiter evaluated by flow volume loop curves. ( 8778168 )
1996
23
Bone metabolism in premenopausal women with nontoxic goiter and reduced serum thyrotropin levels. ( 7536445 )
1994
24
Radioiodine uptake as a function of stored iodine and thyroglobulin in thyroid follicles: in vitro quantitative imaging approach with secondary ion mass spectrometry (SIMS) microscopy in human nontoxic goiter. ( 7920005 )
1994
25
Superior vena cava syndrome due to a substernal nontoxic goiter. ( 8004873 )
1994
26
Thyroid hormone suppressive therapy of sporadic nontoxic goiter. ( 1422239 )
1992
27
Determinants of outcome in sporadic nontoxic goiter. ( 1284332 )
1992
28
Hypervascularity of nontoxic goiter as shown by color-coded Doppler sonography. ( 1772472 )
1991
29
Interrelationships between age, thyroid volume, thyroid nodularity, and thyroid function in patients with sporadic nontoxic goiter. ( 2239979 )
1990
30
Bone Gla protein and sex hormone-binding globulin in nontoxic goiter: parameters for metabolic status at the tissue level. ( 2294139 )
1990
31
Transforming growth factor beta regulates thyroid growth. Role in the pathogenesis of nontoxic goiter. ( 2921318 )
1989
32
Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease. ( 3130398 )
1988
33
Increased thyroidal T4/T3 ratio in nodular and paranodular tissues of nontoxic goiter following suppressive treatment with thyroid hormones. ( 3570153 )
1987
34
Serum thyroglobulin concentration in nontoxic goiter and response to surgery with special reference to risk of goiter relapse. ( 3092474 )
1986
35
Triiodothyronine suppression of diffuse nontoxic goiter. ( 6470438 )
1984
36
Serum thyroglobulin in patients undergoing subtotal thyroidectomy for toxic and nontoxic goiter. ( 7108151 )
1982
37
Seasonal variation of stable intrathyroidal iodine in nontoxic goiter disclosed by x-ray fluorescence. ( 7096913 )
1982
38
Endemic and sporadic nontoxic goiter. ( 7033981 )
1981
39
Thyroid blood flow rate in man. Electromagnetic flowmetry during operation in euthyroid normal gland, nontoxic goiter, and hyperthyroidism. ( 6459360 )
1981
40
Thyroid uptake on bone scan in a large, multinodular, nontoxic goiter with calcific degeneration. ( 7438651 )
1980
41
Increased serum thyroglobulin levels in patients with nontoxic goiter. ( 755050 )
1978
42
Different sensitivity of 131I uptake and TRH test during thyroxine treatment of nontoxic goiter. ( 122399 )
1978
43
Thyroglobulin and calcitonin in patients with nontoxic goiter. ( 702754 )
1978
44
Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification defect. ( 1165726 )
1975
45
Serum triiodothyronine in simple nontoxic goiter in Sicily. ( 1213666 )
1975
46
Nontoxic goiter-diffuse or nodular. ( 1174255 )
1975
47
Suppressive therapy of nontoxic goiter. ( 4432862 )
1974
48
Thyrotropin response to synthetic thyrotropin-releasing hormone in normal subjects and in patients with nontoxic goiter. ( 4115461 )
1972
49
TSH production rate in nontoxic goiter. ( 5577165 )
1971
50
The salivary iodide trap in nontoxic goiter. ( 5635445 )
1968

Variations for Nontoxic Goiter

Expression for Nontoxic Goiter

Search GEO for disease gene expression data for Nontoxic Goiter.

Pathways for Nontoxic Goiter

GO Terms for Nontoxic Goiter

Cellular components related to Nontoxic Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 BGLAP CALCA FASLG SERPINA7 TPO
2 extracellular region GO:0005576 9.1 BGLAP CALCA FASLG SERPINA7 SHBG TG

Biological processes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.54 CALCA FASLG TSHR
2 positive regulation of cAMP biosynthetic process GO:0030819 9.32 CALCA TSHR
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.26 CALCA TSHR
4 activation of adenylate cyclase activity GO:0007190 9.16 CALCA TSHR
5 hormone biosynthetic process GO:0042446 8.96 TG TPO
6 positive regulation of adenylate cyclase activity GO:0045762 8.62 CALCA TSHR

Sources for Nontoxic Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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