MCID: NNT010
MIFTS: 32

Nontoxic Goiter malady

Category: Endocrine diseases

Aliases & Classifications for Nontoxic Goiter

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Aliases & Descriptions for Nontoxic Goiter:

Name: Nontoxic Goiter 10 47 12 65
Nodule-Thyroid, Non Tox 10
Non-Toxic Simple Goitre 10
 
Goiter, Non-Toxic Nos 10
Goitre, Non-Toxic Nos 10
Non-Toxic Goitre 10

Classifications:



External Ids:

Disease Ontology10 DOID:13195
NCIt42 C35271
UMLS65 C0221777

Summaries for Nontoxic Goiter

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MalaCards based summary: Nontoxic Goiter, also known as nodule-thyroid, non tox, is related to dementia and autoimmune thyroiditis. An important gene associated with Nontoxic Goiter is TG (Thyroglobulin), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Insulin secretion. Affiliated tissues include thyroid, heart and skin.

Related Diseases for Nontoxic Goiter

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Diseases related to Nontoxic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.2BGLAP, CALCA
2autoimmune thyroiditis10.3TG, TPO
3thyroid ectopia10.3TG, TPO
4neonatal meningitis10.3TG, TPO
5rhabdomyosarcoma, embryonal, 210.3TG, TPO
6dermatitis10.3
7contact dermatitis10.3
8adenocarcinoma10.3
9allergic contact dermatitis10.3
10retinitis10.3
11pancreatitis10.3
12solar retinopathy10.3TG, TPO
13setariasis10.3TG, TPO
14allergic rhinitis10.3
15rhinitis10.3
16pneumonia10.3
17hypothryoidism, congenital, nongoitrous 410.3TG, TPO
18megaloblastic anemia10.3TG, TPO
19glaucoma, primary open angle, juvenile-onset, 210.3TG, TPO
20fibrogenesis imperfecta ossium10.2ALPP, BGLAP
21diabetic angiopathy10.2ALPP, BGLAP
22chronic inflammatory demyelinating polyradiculoneuropathy10.2TG, TSHR
23iatrogenic or traumatic pituitary deficiency10.2TG, TSHR
24pseudopseudohypoparathyroidism10.2ALPP, BGLAP
25perivascular epithelioid cell tumor10.2TG, TSHR
26deafness, autosomal recessive 4, with enlarged vestibular aqueduct10.2TG, TPO
27hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.2TG, TSHR
28stenosis of lacrimal sac10.2ALPP, TG
29bone structure disease10.2ALPP, BGLAP
30fuchs' heterochromic uveitis10.2TG, TSHR
31systemic lupus erythematosus10.1
32malaria10.1
33mucopolysaccharidosis vii10.1
34anorexia nervosa10.1
35keratitis10.1
36hypertriglyceridemia10.1
37nasopharyngeal carcinoma10.1
38deficiency anemia10.1
39burns10.1
40cholangiocarcinoma10.1
41dengue disease10.1
42pancreatic ductal adenocarcinoma10.1
43pulmonary fibrosis10.1
44cervical dystonia10.1
45oral squamous cell carcinoma10.1
46pleurisy10.1
47nasopharyngitis10.1
48typhus10.1
49tick paralysis10.1
50lyme disease10.1

Graphical network of the top 20 diseases related to Nontoxic Goiter:



Diseases related to nontoxic goiter

Symptoms for Nontoxic Goiter

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Drugs & Therapeutics for Nontoxic Goiter

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Interventional clinical trials:

idNameStatusNCT IDPhase
1rhTSH, Thyroid Size, and Radioiodine Therapy in Benign GoiterCompletedNCT00145366Phase 2
2rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular GoiterCompletedNCT00275171Phase 2
3Outcomes of Different Thyroid Resections for Multinodular Non-toxic GoiterCompletedNCT00946894
4Changes in Quality of Life Following Surgical Treatment of Benign Non-toxic GoiterRecruitingNCT02651818
5ThyrOp: A Study of Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic GoiterRecruitingNCT01358136
6Goitres Influence on Voice Function - The Impact of SurgeryRecruitingNCT02468921

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Genetic Tests for Nontoxic Goiter

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Anatomical Context for Nontoxic Goiter

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MalaCards organs/tissues related to Nontoxic Goiter:

33
Thyroid, Heart, Skin, Endothelial, Kidney, B cells, Monocytes

Animal Models for Nontoxic Goiter or affiliated genes

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Publications for Nontoxic Goiter

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Articles related to Nontoxic Goiter:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
L-Serine deficiency elicits intracellular accumulation of cytotoxic deoxy-sphingolipids and lipid body formation. (25903138)
2015
2
Animal models for assessment of infection and inflammation: contributions to elucidating the pathophysiology of sudden infant death syndrome. (25870597)
2015
3
FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. (26124079)
2015
4
Transport of eicosapentaenoic acid-derived PGEa88, PGF(3I+), and TXBa88 by ABCC4. (25275481)
2014
5
Interventions available over the counter and advice for acute low back pain: systematic review and meta-analysis. (24373568)
2014
6
Half-dose recombinant tissue plasminogen activator treatment in venous thromboembolism. (24104460)
2014
7
Granzyme B gene polymorphisms, colorectal cancer risk, and metastasis. (25313744)
2014
8
Inherited thrombophilia-related complications in the treatment of a biatrial thrombus. (23249615)
2013
9
High-fat diet promotes lung fibrosis and attenuates airway eosinophilia after exposure to cockroach allergen in mice. (24102347)
2013
10
Preventing Ovarian Cancer through Genetic Testing: a Population-Based Study. (24199689)
2013
11
High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma. (23071320)
2012
12
A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function. (22521416)
2012
13
HIWI is associated with prognosis in patients with hepatocellular carcinoma after curative resection. (21989785)
2012
14
The roles of COMT val158met status and aviation expertise in flight simulator performance and cognitive ability. (21193954)
2011
15
Herpes zoster and meningitis due to reactivation of varicella vaccine virus in an immunocompetent child. (20844461)
2011
16
West Nile virus neuroinvasive disease presenting with acute flaccid paralysis and bilateral sensorineural hearing loss. (21442461)
2011
17
HLA-C C1C2 heterozygosity may protect women bearing the killer immunoglobulin-like receptor AA genotype from spontaneous abortion. (21134695)
2011
18
Immunohistochemical expression of CXCR4 in thyroid carcinomas and thyroid benign lesions. (20646838)
2010
19
Risk factors and comorbidities in a community-wide sample of patients hospitalized with acute systolic or diastolic heart failure: the Worcester Heart Failure Study. (20305550)
2010
20
Biotinidase deficiency with hypertonia as unusual feature. (19179722)
2009
21
Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506). (19759356)
2009
22
Effect of the NMDA-receptor antagonist dextromethorphan in infant rat pneumococcal meningitis. (18220575)
2008
23
Biology of thioredoxin and its association with Alzheimer's disease and Parkinson's disease]. (18357724)
2008
24
Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase. (17915953)
2007
25
Lymphocytic vasculitis associated with icodextrin. (17984440)
2007
26
Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells. (15640154)
2005
27
In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood. (15668107)
2005
28
Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development. (16172982)
2005
29
Localization of precursor proteins and mRNA of type I and III collagens in usual interstitial pneumonia and sarcoidosis. (16521042)
2005
30
Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. (15138291)
2004
31
Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma. (12393409)
2003
32
Multiple spontaneous enterocutaneous fistulae in malakoplakia. (15030043)
2003
33
Retinal oxygen saturation levels in patients with central retinal vein occlusion. (12153805)
2002
34
Cardiac cephalgia is not necessarily an exertional headache: case report. (12421163)
2002
35
C282Y and H63D mutations of the haemochromatosis gene in patients with iron overload. (11488107)
2001
36
Gene therapy for human bypass grafts. (11370767)
2001
37
Persistence of both peripheral and non-peripheral corneodesmosomes in the upper stratum corneum of winter xerosis skin versus only peripheral in normal skin. (11168794)
2001
38
Raltitrexed ('Tomudex') and radiotherapy can be combined as postoperative treatment for rectal cancer. (11038040)
2000
39
Inhibition of monocyte chemotactic protein-1 synthesis by statins. (10908155)
2000
40
HLA-DQ locus of the human leukocyte antigen complex and type 1 diabetes mellitus: a HuGE review. (11218373)
2000
41
Invasive lobular and invasive ductal carcinoma of the breast show distinct patterns of vascular endothelial growth factor expression and angiogenesis. (9828838)
1998
42
Antibody-dependent difference in biodistribution of monoclonal antibodies in animal models and humans. (9756415)
1998
43
Persistent scleredema of Buschke in a diabetic: improvement with high-dose penicillin. (8731692)
1996
44
Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. (7693711)
1993
45
Survival following thrombolytic therapy. (2121486)
1990
46
Cyclic AMP increases thrombomodulin expression on membrane surface of cultured human umbilical vein endothelial cells. (1700492)
1990
47
Molecular basis of medium chain acyl-coenzyme A dehydrogenase deficiency. An A to G transition at position 985 that causes a lysine- 304 to glutamate substitution in the mature protein is the single prevalent mutation. (2394825)
1990
48
Effect of 3,4-methylenedioxymethamphetamine on 3,4-dihydroxyphenylalanine accumulation in the striatum and nucleus accumbens. (1689375)
1990
49
Ovarian remnant syndrome. (7054843)
1982
50
Role of the renal nerves in the pathogenesis of one-kidney renal hypertension in the rat. (7030950)
1981

Variations for Nontoxic Goiter

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Expression for genes affiliated with Nontoxic Goiter

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Search GEO for disease gene expression data for Nontoxic Goiter.

Pathways for genes affiliated with Nontoxic Goiter

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GO Terms for genes affiliated with Nontoxic Goiter

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Biological processes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:00424469.7TG, TPO
2thyroid hormone generationGO:00065909.3TG, TPO
3activation of adenylate cyclase activityGO:00071909.0CALCA, TSHR
4cell-cell signalingGO:00072678.4CALCA, FASLG, TSHR

Sources for Nontoxic Goiter

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet