MCID: NNT010
MIFTS: 36

Nontoxic Goiter malady

Endocrine diseases category

Aliases & Classifications for Nontoxic Goiter

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 25ICD10
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Nontoxic Goiter, Aliases & Descriptions:

Name: Nontoxic Goiter 9 43 60
Nodule-Thyroid, Non Tox 9
Non-Toxic Simple Goitre 9
 
Goiter, Non-Toxic Nos 9
Goitre, Non-Toxic Nos 9
Non-Toxic Goitre 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:13195
NCIt38 C35271
ICD1025 E04.8

Summaries for Nontoxic Goiter

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MalaCards based summary: Nontoxic Goiter, also known as nodule-thyroid, non tox, is related to goiter and thyroiditis. An important gene associated with Nontoxic Goiter is BGLAP (bone gamma-carboxyglutamate (gla) protein), and among its related pathways are Transcription Role of VDR in regulation of genes involved in osteoporosis and Insulin secretion. The compounds triiodothyroacetic acid and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Related Diseases for Nontoxic Goiter

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Diseases related to Nontoxic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.2BGLAP, TPO, TG, TSHR
2thyroiditis30.6TSHR, FASLG, TG, TPO
3myxedema30.2TPO, TG, TSHR
4thyrotoxicosis30.2TPO, TG, TSHR
5hyperthyroidism29.9TSHR, TG, TPO, BGLAP
6thyroid cancer29.9TSHR, TG, TPO, BGLAP
7graves' disease29.8BGLAP, TPO, TG, FASLG, TSHR
8subacute thyroiditis10.4TG
9thyroxine-binding globulin deficiency10.2
10cervicitis10.2
11respiratory failure10.2
12superior vena cava syndrome10.2
13blindness10.2
14goiter, multinodular 1, with or without sertoli-leydig cell tumors10.2TG, TPO
15pernicious anemia10.2TPO, TG
16plummer's disease10.1TG, TPO
17hypothryoidism, congenital, nongoitrous 410.1TPO, TG
18autoimmune thyroiditis10.1TG, TPO
19pendred syndrome10.1TPO, TG
20hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.1TG, TSHR
21struma ovarii10.1TSHR, TG
22hyperthyroxinemia10.1TSHR, TPO
23thyroid carcinoma, follicular10.1TSHR, TG
24addison's disease10.1TPO, TG
25celiac disease10.0TG, TPO
26turner syndrome10.0BGLAP, TPO, TG
27down syndrome10.0TSHR, TPO
28diabetes mellitus, insulin-dependent9.9TPO, FASLG
29toxic diffuse goiter9.9TSHR, TG, TPO
30endemic goiter9.9TPO, TG, TSHR
31multinodular goiter9.9TSHR, TG, TPO
32nodular goiter9.9TSHR, TG, TPO
33congenital hypothyroidism9.9TSHR, TG, TPO
34thyroid adenoma9.9TSHR, TG, TPO
35thyroid cancer, anaplastic9.9TSHR, TG, TPO
36follicular adenoma9.9TSHR, TG, TPO
37papillary carcinoma9.9TPO, TG, TSHR
38thyroid carcinoma, papillary9.9TSHR, TG, TPO
39hypothyroidism9.9TPO, TG, TSHR
40viral hepatitis9.9TSHR, FASLG
41sjogren's syndrome9.8TSHR, FASLG
42adenoma9.7TSHR, TG, TPO
43osteosarcoma, somatic9.7BGLAP, FASLG, TSHR
44hypersensitivity reaction type ii disease9.7TSHR, FASLG
45systemic lupus erythematosus9.7TPO, FASLG, TSHR
46hashimoto thyroiditis9.6TPO, TG, FASLG, TSHR

Graphical network of the top 20 diseases related to Nontoxic Goiter:



Diseases related to nontoxic goiter

Symptoms for Nontoxic Goiter

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Drugs & Therapeutics for Nontoxic Goiter

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Drug clinical trials:

Search ClinicalTrials for Nontoxic Goiter

Search NIH Clinical Center for Nontoxic Goiter

Genetic Tests for Nontoxic Goiter

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Anatomical Context for Nontoxic Goiter

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MalaCards organs/tissues related to Nontoxic Goiter:

31
Thyroid, Bone, Testes

Animal Models for Nontoxic Goiter or affiliated genes

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MGI Mouse Phenotypes related to Nontoxic Goiter:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0TSHR, FASLG, TG, TPO
2MP:00053797.9TSHR, FASLG, TG, TPO
3MP:00053977.7TPO, TG, FASLG, TSHR

Publications for Nontoxic Goiter

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Articles related to Nontoxic Goiter:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
Quality of life in patients with benign nontoxic goiter: impact of disease and treatment response, and comparison with the general population. (25602312)
2015
2
Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter. (24482635)
2014
3
Incidental thyroid cancer in toxic and nontoxic goiter: Is TSH associated with malignanCy rate? Results of a meta-analysis. (23186976)
2013
4
Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter. (22577172)
2012
5
Total thyroidectomy: is morbidity higher for Graves' disease than nontoxic goiter? (21550063)
2011
6
Acute respiratory failure caused by neglected giant substernal nontoxic goiter. (21655873)
2011
7
Radioiodine treatment of Plummer and multinodular toxic and nontoxic goiter disease by the first approximation dosimetry method. (17600473)
2007
8
Metastasis as presenting feature of thyroid follicular carcinoma; report of a patient thyroidectomized for benign multinodular nontoxic goiter. (16029132)
2005
9
Evaluation and treatment of sporadic nontoxic goiter--some answers and more questions. (11238475)
2001
10
A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. (11238476)
2001
11
Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. (10690902)
2000
12
Tc-99m MDP thyroid uptake in a patient with a large nontoxic goiter. (11079599)
2000
13
Postural changes of the cervical spine in patients with nontoxic goiter. (9868630)
1998
14
Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. (9284721)
1997
15
Long-term observation of serum thyroglobulin after resection of nontoxic goiter and relation to ultrasonographically demonstrated relapse. (8661844)
1996
16
Improvement of upper airway obstruction after 131I-treatment of multinodular nontoxic goiter evaluated by flow volume loop curves. (8778168)
1996
17
Superior vena cava syndrome due to a substernal nontoxic goiter. (8004873)
1994
18
Bone metabolism in premenopausal women with nontoxic goiter and reduced serum thyrotropin levels. (7536445)
1994
19
Determinants of outcome in sporadic nontoxic goiter. (1284332)
1992
20
Bone Gla protein and sex hormone-binding globulin in nontoxic goiter: parameters for metabolic status at the tissue level. (2294139)
1990
21
Interrelationships between age, thyroid volume, thyroid nodularity, and thyroid function in patients with sporadic nontoxic goiter. (2239979)
1990
22
Transforming growth factor beta regulates thyroid growth. Role in the pathogenesis of nontoxic goiter. (2921318)
1989
23
Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease. (3130398)
1988
24
Increased thyroidal T4/T3 ratio in nodular and paranodular tissues of nontoxic goiter following suppressive treatment with thyroid hormones. (3570153)
1987
25
Serum thyroglobulin concentration in nontoxic goiter and response to surgery with special reference to risk of goiter relapse. (3092474)
1986
26
Triiodothyronine suppression of diffuse nontoxic goiter. (6470438)
1984
27
Seasonal variation of stable intrathyroidal iodine in nontoxic goiter disclosed by x-ray fluorescence. (7096913)
1982
28
Serum thyroglobulin in patients undergoing subtotal thyroidectomy for toxic and nontoxic goiter. (7108151)
1982
29
Endemic and sporadic nontoxic goiter. (7033981)
1981
30
Thyroid blood flow rate in man. Electromagnetic flowmetry during operation in euthyroid normal gland, nontoxic goiter, and hyperthyroidism. (6459360)
1981
31
Thyroid uptake on bone scan in a large, multinodular, nontoxic goiter with calcific degeneration. (7438651)
1980
32
Different sensitivity of 131I uptake and TRH test during thyroxine treatment of nontoxic goiter. (122399)
1978
33
Increased serum thyroglobulin levels in patients with nontoxic goiter. (755050)
1978
34
Thyroglobulin and calcitonin in patients with nontoxic goiter. (702754)
1978
35
Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification defect. (1165726)
1975
36
Nontoxic goiter-diffuse or nodular. (1174255)
1975
37
Serum triiodothyronine in simple nontoxic goiter in Sicily. (1213666)
1975
38
Suppressive therapy of nontoxic goiter. (4432862)
1974
39
Thyrotropin response to synthetic thyrotropin-releasing hormone in normal subjects and in patients with nontoxic goiter. (4115461)
1972
40
TSH production rate in nontoxic goiter. (5577165)
1971
41
Defective intrathyroidal iodine metabolism in nontoxic goiter: inadequate iodination of thyroglobulin. (5679994)
1968
42
DYNAMIC DISTURBANCES OF INTRATHYROID IODINE METABOLISM IN SPORADIC NONTOXIC GOITER. (14167072)
1964
43
Treatment of nontoxic goiter with sodium liothyronine. A double-blind study. (13966033)
1963
44
The thiocyanate suppression test--a new and simple test for differential diagnosis between hyperthyrodism and nontoxic goiter. (14496764)
1962
45
System of radioiodine therapy for thyrotoxicosis and nontoxic goiter involving measurement of thyroidal radiosensitivity. (13727257)
1961
46
Nontoxic goiter. (13812866)
1960
47
Clinical-pathologic study of 76 cases of recurrent Graves' disease, toxic (non-exophthalmic) goiter, and nontoxic goiter; does a relation exist between thyroid hyperplasia and struma lymphomatosa? (13424488)
1957
48
Congenital, hereditary, diffuse nontoxic goiter as a cause of persistent face presentation. (13080366)
1953
49
The effects of L-thyroxine sodium on nontoxic goiter, on myxedema and on the thyroid uptake of radioactive iodine. (13002643)
1952
50
Some surgical problems of nontoxic goiter. (14778880)
1950

Variations for Nontoxic Goiter

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Expression for genes affiliated with Nontoxic Goiter

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Search GEO for disease gene expression data for Nontoxic Goiter.

Pathways for genes affiliated with Nontoxic Goiter

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Compounds for genes affiliated with Nontoxic Goiter

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Compounds related to Nontoxic Goiter according to GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1triiodothyroacetic acid439.9BGLAP, TG
2iodotyrosine43 2410.8TG, TPO
3diiodotyrosine439.8TG, TPO
4perchlorate439.8TPO, TG
5gliadin439.7TPO, TG
6amiodarone43 49 28 1212.7TPO, TG
7amino acid439.6TPO, TSHR
8cardiolipin43 1210.6TG, TPO
9maltose43 1210.6TPO, TSHR
10atpo28 4310.5TPO, FASLG
11hydrocortisone43 2 59 1212.3TPO, TG, BGLAP
12carbimazole43 1210.3TSHR, TPO, BGLAP
13sodium iodide439.3TPO, TSHR, TG
14prednisolone43 28 1211.3BGLAP, TG, TSHR
15propylthiouracil43 2 1211.3TSHR, TG, TPO
16iodine43 2410.2TG, TSHR, TPO
17nitrate439.2FASLG, TPO
18125i439.2TSHR, TG, TPO
19iodide43 2410.2TSHR, TG, TPO
20triiodothyronine439.2TSHR, TG, TPO
21ribonucleic acid439.1TPO, TSHR, TG
22tetracycline43 1210.1BGLAP, FASLG, TPO
23chromium439.0TG, TPO, FASLG
24gold439.0TG, FASLG, TPO
25creatinine439.0TG, TPO, BGLAP
26cyclosporin a43 28 5910.9FASLG, TG, BGLAP
27agarose438.9FASLG, TPO, TSHR
28depsipeptide438.8FASLG, TG
29genistein43 28 59 2 24 1213.8TPO, TG, FASLG
30estradiol43 24 1210.8FASLG, BGLAP, TSHR
31methimazole43 2 1210.8TSHR, TG, BGLAP, TPO
32thyroxine43 249.8TG, BGLAP, TSHR, TPO
33sodium43 249.7TPO, TG, TSHR
34arginine438.7TPO, BGLAP, TG, TSHR
35cisplatin43 49 59 1211.7TG, FASLG, BGLAP
36thymidine43 249.6TSHR, FASLG, TG
37ascorbic acid43 249.6FASLG, TG, BGLAP, TPO
38h2o2438.5BGLAP, TG, TPO, FASLG
39testosterone43 59 24 1211.5TPO, BGLAP, FASLG, TG
40paraffin438.5BGLAP, TG, TSHR, FASLG
41polysaccharide438.4TG, TPO, FASLG, TSHR
42vegf438.4TG, BGLAP, TSHR, FASLG
43alanine438.4BGLAP, TSHR, FASLG, TG
44adenylate438.4TSHR, TPO, FASLG, TG
45estrogen438.4BGLAP, TSHR, FASLG, TG
46glutamate438.3TPO, TG, FASLG, TSHR
47serine438.2FASLG, TSHR, BGLAP, TG
48aspartate438.0BGLAP, TG, FASLG, TSHR, TPO
49retinoic acid43 249.0TSHR, FASLG, TG, BGLAP, TPO
50cysteine438.0FASLG, TPO, BGLAP, TG, TSHR

GO Terms for genes affiliated with Nontoxic Goiter

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Cellular components related to Nontoxic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.5TSHR, FASLG, TPO
2extracellular spaceGO:00056157.9FASLG, TG, TPO, BGLAP

Biological processes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00065909.4TG, TPO
2hormone biosynthetic processGO:00424469.1TG, TPO

Products for genes affiliated with Nontoxic Goiter

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Sources for Nontoxic Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet