MCID: NNT010
MIFTS: 44

Nontoxic Goiter malady

Endocrine diseases category

Summaries for Nontoxic Goiter

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MalaCards: Nontoxic Goiter, also known as nodule-thyroid, non tox, is related to goiter and thyroiditis. An important gene associated with Nontoxic Goiter is TG (thyroglobulin), and among its related pathways are Insulin secretion and Allograft rejection. The compounds propylthiouracil and chromium have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Classifications for Nontoxic Goiter

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

nontoxic goiter 8 44 60
nodule-thyroid, non tox 8
non-toxic simple goitre 8
goitre, non-toxic nos 8
goiter, non-toxic nos 8
non-toxic goitre 8


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Disease Ontology8 DOID:13195
NCIt39 C35271
ICD1025 E04.8

Related Diseases for Nontoxic Goiter

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17GeneCards, 18GeneDecks
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Diseases related to Nontoxic Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.5BGLAP, TRH, TSHR, TPO, TG
2thyroiditis31.1FASLG, TRH, TSHR, TPO, TG
3multinodular goiter30.8TSHR, TPO, TG
4graves' disease30.6BGLAP, FASLG, TSHR, TPO, TG
5nodular goiter30.5TG, TPO, TSHR
6autoimmune thyroiditis30.2TPO, TG
7follicular thyroid carcinoma30.2TSHR, TG
8endemic goiter30.2TSHR, TPO, TG
9myxedema30.2TSHR, TPO, TG
10thyrotoxicosis30.2TRH, TSHR, TPO, TG
11hyperthyroidism30.2TG, TPO, TSHR, TRH, BGLAP
12thyroid cancer30.2TG, TPO, TSHR, TRH, BGLAP
13substernal goiter10.3
14cervicitis10.1
15respiratory failure10.1
16subacute thyroiditis10.0TG
17diabetes insipidus10.0TRH
18endogenous depression10.0TRH
19deficiency anemia10.0TRH
20neonatal thyrotoxicosis10.0TSHR
21vitiligo10.0TPO
22hyperprolactinemia10.0TRH
23obesity10.0TRH
24diabetes mellitus10.0BGLAP
25celiac disease10.0TPO, TG
26addison's disease10.0TG, TPO
27pernicious anemia10.0TG, TPO
28amenorrhea10.0TRH
29arthritis10.0BGLAP
30plummer's disease10.0TPO, TG
31hepatitis10.0FASLG
32thyrotropin deficiency, isolated10.0TG, TPO
33pseudohypoparathyroidism10.0BGLAP
34thyroid hormone resistance syndrome10.0TRH, TG
35pendred syndrome10.0TG, TPO
36thyroid agenesis10.0TSHR, TG
37struma ovarii10.0TSHR, TG
38pregnancy loss10.0TG, TPO
39hypoparathyroidism10.0BGLAP
40down syndrome10.0TPO, TSHR
41exophthalmos10.0TSHR, TRH
42viral hepatitis10.0FASLG, TSHR
43type 1 diabetes10.0FASLG, TPO
44prolactinoma10.0TRH
45cholera10.0TSHR, TRH
46thyroid adenoma10.0TG, TPO, TSHR
47toxic diffuse goiter10.0TG, TPO, TSHR
48congenital hypothyroidism10.0TSHR, TPO, TG
49thyroid cancer, anaplastic10.0TG, TPO, TSHR
50follicular adenoma10.0TSHR, TPO, TG

Graphical network of the top 20 diseases related to Nontoxic Goiter:



Diseases related to nontoxic goiter

Clinical Features for Nontoxic Goiter

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Drugs & Therapeutics for Nontoxic Goiter

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Nontoxic Goiter

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Anatomical Context for Nontoxic Goiter

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32MalaCards
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MalaCards organs/tissues related to Nontoxic Goiter:

32
Thyroid, Bone, Testes, Endothelial

Animal Models for Nontoxic Goiter or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nontoxic Goiter:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.6TG, TSHR, FASLG
2MP:00053767.9TG, TPO, TSHR, TRH, FASLG

Publications for Nontoxic Goiter

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50PubMed
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Articles related to Nontoxic Goiter:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Does unilateral lobectomy suffice to manage unilateral nontoxic goiter? (19703811)
2010
2
The odyssey of nontoxic nodular goiter (NTNG) in Greece under suppression therapy, and after improvement of iodine deficiency. (18578614)
2008
3
The comparison of serum vascular endothelial growth factor levels between patients with metastatic and non-metastatic thyroid cancer, and patients with nontoxic multinodular goiter. (17893268)
2007
4
Transient goiter enlargement after administration of 0.3 mg of recombinant human thyrotropin in patients with benign nontoxic nodular goiter: a randomized, double-blind, crossover trial. (16434453)
2006
5
Safety and efficacy of administering 0.2 mg of recombinant human TSH for two consecutive days as an adjuvant to therapy with low radioiodine doses in elderly out-patients with large nontoxic multinodular goiter. (17213787)
2006
6
Management of the nontoxic multinodular goiter in Latin America: comparison with North America and Europe, an electronic survey. (15483102)
2005
7
Ultrasound-guided laser thermal ablation in the treatment of autonomous hyperfunctioning thyroid nodules and compressive nontoxic nodular goiter. (14611703)
2003
8
Management of the nontoxic multinodular goiter: a North American survey. (11788632)
2002
9
A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. (11238476)
2001
10
Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. (10690902)
2000
11
Tc-99m MDP thyroid uptake in a patient with a large nontoxic goiter. (11079599)
2000
12
The effect of iodine administration on the development of thyroid autoimmunity in patients with nontoxic goiter. (10907993)
2000
13
Is routine thyroxine treatment to hinder postoperative recurrence of nontoxic goiter justified? (10022449)
1999
14
Postural changes of the cervical spine in patients with nontoxic goiter. (9868630)
1998
15
Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. (9284721)
1997
16
Long-term observation of serum thyroglobulin after resection of nontoxic goiter and relation to ultrasonographically demonstrated relapse. (8661844)
1996
17
Diffuse nontoxic and multinodular goiter. (7704811)
1994
18
Bone metabolism in premenopausal women with nontoxic goiter and reduced serum thyrotropin levels. (7536445)
1994
19
Radioiodine uptake as a function of stored iodine and thyroglobulin in thyroid follicles: in vitro quantitative imaging approach with secondary ion mass spectrometry (SIMS) microscopy in human nontoxic goiter. (7920005)
1994
20
Levothyroxine suppressive therapy in the medical management of nontoxic benign multinodular goiter. (8299711)
1993
21
Dosimetric determination of I-131 activity in the treatment of recurrent, nontoxic, multinodular goiter. (8319402)
1993
22
Thyroid hormone suppressive therapy of sporadic nontoxic goiter. (1422239)
1992
23
The lack of nocturnal serum thyrotropin surge in patients with nontoxic nodular goiter may predict the subsequent occurrence of hyperthyroidism. (1874936)
1991
24
Interrelationships between age, thyroid volume, thyroid nodularity, and thyroid function in patients with sporadic nontoxic goiter. (2239979)
1990
25
Lack of response of peripheral blood mononuclear cells to thyroid microsomal antigen in nontoxic nodular goiters. (2121217)
1990
26
Nontoxic nodular goiter and papillary thyroid carcinoma are not associated with peripheral blood lymphocyte sensitization to thyroid cells. (2462573)
1989
27
Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease. (3130398)
1988
28
Triiodothyronine suppression of diffuse nontoxic goiter. (6470438)
1984
29
Studies on T and B lymphocytes by the technique of immune and non-immune rosettes and by scanning electron microscopy (SEM) in Graves' disease and nontoxic nodular goiter. (6607508)
1983
30
Serum thyroglobulin in patients undergoing subtotal thyroidectomy for toxic and nontoxic goiter. (7108151)
1982
31
Endemic and sporadic nontoxic goiter. (7033981)
1981
32
Thyroid uptake on bone scan in a large, multinodular, nontoxic goiter with calcific degeneration. (7438651)
1980
33
Different sensitivity of 131I uptake and TRH test during thyroxine treatment of nontoxic goiter. (122399)
1978
34
Increased serum thyroglobulin levels in patients with nontoxic goiter. (755050)
1978
35
Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification defect. (1165726)
1975
36
Nontoxic goiter-diffuse or nodular. (1174255)
1975
37
Serum triiodothyronine in simple nontoxic goiter in Sicily. (1213666)
1975
38
TSH production rate in nontoxic goiter. (5577165)
1971
39
Defective intrathyroidal iodine metabolism in nontoxic goiter: inadequate iodination of thyroglobulin. (5679994)
1968
40
The salivary iodide trap in nontoxic goiter. (5635445)
1968
41
DYNAMIC DISTURBANCES OF INTRATHYROID IODINE METABOLISM IN SPORADIC NONTOXIC GOITER. (14167072)
1964
42
ABNORMAL IODOPROTEIN IN NONTOXIC GOITER. (14052265)
1963
43
Nontoxic nodular goiter. (13971357)
1963
44
Thyroid proteins in sporadic nontoxic goiter. (13970154)
1963
45
Nontoxic nodular goiter with formation and release of a compound with the chromatographic mobility characteristics of triiodothyronine. (13784480)
1960
46
Clinical-pathologic study of 76 cases of recurrent Graves' disease, toxic (non-exophthalmic) goiter, and nontoxic goiter; does a relation exist between thyroid hyperplasia and struma lymphomatosa? (13424488)
1957
47
Congenital, hereditary, diffuse nontoxic goiter as a cause of persistent face presentation. (13080366)
1953
48
The effects of L-thyroxine sodium on nontoxic goiter, on myxedema and on the thyroid uptake of radioactive iodine. (13002643)
1952
49
Clinical differentiation of various types of nontoxic nodular goiter. (18120036)
1949
50
The differentiation of hyperthyroidism in patients with nontoxic nodular goiter. (18105753)
1947-1948

Genetic Variations for Nontoxic Goiter

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Expression for genes affiliated with Nontoxic Goiter

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nontoxic Goiter

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Pathways for genes affiliated with Nontoxic Goiter

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29KEGG, 12EMD Millipore
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Pathways related to Nontoxic Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.6TG, TPO
2
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9.1TG, TPO, TSHR
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.0FASLG, BGLAP

Compounds for genes affiliated with Nontoxic Goiter

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44Novoseek, 2BitterDB, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Nontoxic Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1propylthiouracil44 2 1112.5TG
2chromium4410.4TPO
3iodotyrosine44 2411.0TG, TPO
4diiodotyrosine4410.0TPO, TG
5perchlorate4410.0TG, TPO
6gliadin449.8TPO, TG
7amino acid449.7TPO, TSHR
8atpo44 2810.7TPO, FASLG
9cycloheximide449.7TRH, FASLG
10maltose44 1110.6TSHR, TPO
11triiodothyroacetic acid449.6TG, BGLAP
12amiodarone44 49 28 1112.6TG, TPO
13cardiolipin44 1110.6TG, TPO
14sodium iodide449.5TPO, TSHR, TG
15125i449.5TPO, TG, TSHR
16iodide44 2410.5TSHR, TPO, TG
17gold449.3TG, FASLG, TPO
18acth449.2TSHR, TRH, TPO
19glutaraldehyde449.2TG, TRH
20ribonucleic acid449.2TG, TSHR, TPO
21agarose449.2FASLG, TSHR, TPO
22carbimazole44 1110.1TSHR, TPO, BGLAP
23prednisolone44 28 1111.1TG, TSHR, BGLAP
24iodine44 2410.0TRH, TPO, TG, TSHR
25triiodothyronine449.0TPO, TG, TSHR, TRH
26acetylcholine44 49 28 11 2413.0TG, TRH, TPO
27tetracycline44 119.9TPO, BGLAP, FASLG
28polysaccharide448.9TG, TPO, TSHR, FASLG
29cysteine448.8FASLG, TG, TPO, TSHR
30thymidine44 249.8FASLG, TSHR, TRH, TG
31gnrh448.7BGLAP, TRH, FASLG
32hydrocortisone44 2 59 1111.7BGLAP, TRH, TPO, TG
33oligonucleotide448.6FASLG, TRH, TSHR, TPO
34ascorbic acid44 249.6BGLAP, TPO, FASLG, TG
35h2o2448.5TPO, FASLG, BGLAP, TG
36paraffin448.5TG, TSHR, BGLAP, FASLG
37adenylate448.4TG, TSHR, FASLG, TRH, TPO
38estradiol44 11 2410.4TSHR, FASLG, TRH, BGLAP
39vegf448.4TG, TSHR, BGLAP, FASLG
40glutamate448.3TRH, TSHR, FASLG, TPO, TG
41alanine448.3FASLG, TG, TSHR, BGLAP
42tyrosine448.2TRH, FASLG, TG, TPO, TSHR
43methimazole44 2 1110.2BGLAP, TRH, TSHR, TG, TPO
44thyroxine44 249.2BGLAP, TG, TPO, TSHR, TRH
45arginine448.2TSHR, TPO, BGLAP, TRH, TG
46aspartate448.1BGLAP, FASLG, TSHR, TPO, TG
47testosterone44 59 11 2411.1TPO, TRH, BGLAP, FASLG, TG
48retinoic acid44 249.0TPO, FASLG, TG, TSHR, BGLAP
49estrogen448.0BGLAP, TSHR, FASLG, TRH, TG
50calcium44 49 11 2410.6BGLAP, FASLG, TRH, TPO, TSHR

GO Terms for genes affiliated with Nontoxic Goiter

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16Gene Ontology
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Cellular components related to Nontoxic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1TG, TRH, FASLG, BGLAP

Biological processes related to Nontoxic Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.6TG, TPO
2thyroid hormone generationGO:0065909.5TG, TPO
3response to ethanolGO:0454719.1TRH, BGLAP
4cell-cell signalingGO:0072678.5TSHR, TRH, FASLG

Products for genes affiliated with Nontoxic Goiter

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Sources for Nontoxic Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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