MCID: NNT010
MIFTS: 34

Nontoxic Goiter

Categories: Endocrine diseases

Aliases & Classifications for Nontoxic Goiter

MalaCards integrated aliases for Nontoxic Goiter:

Name: Nontoxic Goiter 12 52 14 69
Nodule-Thyroid, Non Tox 12
Non-Toxic Simple Goitre 12
Goiter, Non-Toxic Nos 12
Goitre, Non-Toxic Nos 12
Non-Toxic Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13195
NCIt 47 C35271
UMLS 69 C0221777

Summaries for Nontoxic Goiter

MalaCards based summary : Nontoxic Goiter, also known as nodule-thyroid, non tox, is related to goiter and adenohypophysitis. An important gene associated with Nontoxic Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Allograft rejection and Insulin secretion. The drugs Salmon Calcitonin and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Nontoxic Goiter

Diseases related to Nontoxic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
id Related Disease Score Top Affiliating Genes
1 goiter 10.7
2 adenohypophysitis 10.5 TG TPO
3 maxillary sinus adenoid cystic carcinoma 10.5 TG TPO
4 rhabdomyosarcoma, embryonal, 2 10.5 TG TPO
5 chronic frontal sinusitis 10.5 TG TPO
6 thyroiditis 10.5
7 hypothyroidism, congenital, nongoitrous 4 10.5 TG TPO
8 mediastinum leiomyoma 10.4 BGLAP TG
9 color blindness 10.4 TG TPO
10 c5 deficiency 10.4 TG TPO
11 chronic polyneuropathy 10.4 TG TSHR
12 kidney disease 10.4 TG TSHR
13 echinostomiasis 10.4 SERPINA7 TG
14 panhypophysitis 10.4 TG TSHR
15 parachordoma 10.4 TG TSHR
16 iridocyclitis 10.3 TG TSHR
17 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 10.3 TG TPO
18 hemoglobinopathy 10.3 SERPINA7 TPO
19 graves' disease 10.2
20 childhood mediastinal neurogenic tumor 10.1 CALCA TG
21 corneal ectasia 10.1 CALCA TG
22 cervical endometrial stromal sarcoma 10.1 CALCA TG
23 tick paralysis 10.1 SHBG TG TPO
24 congenital granular cell tumor 10.1 CALCA TG
25 parietal lobe neoplasm 10.1 CALCA TG
26 mixed cell type adenoma of parathyroid 10.1 BGLAP CALCA
27 lung lymphoma 10.1 CALCA TG
28 xanthomatosis 10.1 BGLAP CALCA
29 hypophosphatasia, adult 10.1 BGLAP CALCA
30 fallopian tube leiomyoma 10.0 CALCA TG
31 phacolytic glaucoma 10.0 BGLAP CALCA
32 bacillary angiomatosis 10.0 BGLAP CALCA
33 pes anserinus tendinitis or bursitis 10.0 BGLAP CALCA
34 nephrogenic systemic fibrosis 10.0 TG TPO TSHR
35 opioid abuse 10.0 BGLAP CALCA
36 conjunctival deposit 10.0 TG TPO TSHR
37 combined cellular and humoral immune defects with granulomas 10.0 TG TPO TSHR
38 primary bacterial infectious disease 10.0 TG TPO TSHR
39 tinea unguium 10.0 BGLAP CALCA
40 lymphoma 10.0 TG TPO TSHR
41 chorea, hereditary benign 10.0 TG TPO TSHR
42 astrakhan spotted fever 10.0 BGLAP CALCA
43 pseudohypoparathyroidism 10.0 TG TPO TSHR
44 worth's syndrome 10.0 BGLAP CALCA
45 physical disorder 10.0 BGLAP CALCA
46 acute salpingo-oophoritis 9.9 BGLAP CALCA
47 hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 9.9 SERPINA7 TG TSHR
48 bone deterioration disease 9.9 BGLAP CALCA
49 mild pre-eclampsia 9.9 BGLAP CALCA
50 chronic dacryoadenitis 9.9 CALCA TPO

Graphical network of the top 20 diseases related to Nontoxic Goiter:



Diseases related to Nontoxic Goiter

Symptoms & Phenotypes for Nontoxic Goiter

GenomeRNAi Phenotypes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.6 BGLAP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.6 BGLAP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.6 BGLAP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.6 TPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.6 BGLAP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.6 BGLAP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.6 BGLAP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.6 BGLAP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.6 BGLAP SHBG TPO
10 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.6 BGLAP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.6 SHBG
12 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.6 TPO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.6 SHBG
14 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.6 SHBG
15 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.6 TPO
16 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.6 TPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-69 9.6 SHBG

Drugs & Therapeutics for Nontoxic Goiter

Drugs for Nontoxic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salmon Calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
2 Bone Density Conservation Agents Phase 2
3 calcitonin Phase 2
4 Calcitonin Gene-Related Peptide Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
2 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
3 ThyrOp: A Study of Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter Unknown status NCT01358136
4 Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter Completed NCT00946894
5 Changes in Quality of Life Following Surgical Treatment of Benign Non-toxic Goiter Active, not recruiting NCT02651818
6 Goitres Influence on Voice Function - The Impact of Surgery Active, not recruiting NCT02468921

Search NIH Clinical Center for Nontoxic Goiter

Genetic Tests for Nontoxic Goiter

Anatomical Context for Nontoxic Goiter

MalaCards organs/tissues related to Nontoxic Goiter:

39
Thyroid, Bone, Testes

Publications for Nontoxic Goiter

Articles related to Nontoxic Goiter:

(show top 50) (show all 64)
id Title Authors Year
1
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter. ( 28471268 )
2017
2
Total Thyroidectomy versus Bilateral Subtotal Thyroidectomy for Bilateral Multinodular Nontoxic Goiter: A Meta-Analysis. ( 27256349 )
2016
3
Quality of life in patients with benign nontoxic goiter: impact of disease and treatment response, and comparison with the general population. ( 25602312 )
2015
4
Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter. ( 24482635 )
2014
5
Incidental thyroid cancer in toxic and nontoxic goiter: Is TSH associated with malignanCy rate? Results of a meta-analysis. ( 23186976 )
2013
6
Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter. ( 22577172 )
2012
7
Total thyroidectomy: is morbidity higher for Graves' disease than nontoxic goiter? ( 21550063 )
2011
8
Acute respiratory failure caused by neglected giant substernal nontoxic goiter. ( 21655873 )
2011
9
Does unilateral lobectomy suffice to manage unilateral nontoxic goiter? ( 19703811 )
2010
10
Five-year follow-up of a randomized clinical trial of total thyroidectomy versus Dunhill operation versus bilateral subtotal thyroidectomy for multinodular nontoxic goiter. ( 20174803 )
2010
11
Radioiodine treatment of Plummer and multinodular toxic and nontoxic goiter disease by the first approximation dosimetry method. ( 17600473 )
2007
12
Metastasis as presenting feature of thyroid follicular carcinoma; report of a patient thyroidectomized for benign multinodular nontoxic goiter. ( 16029132 )
2005
13
Evaluation and treatment of sporadic nontoxic goiter--some answers and more questions. ( 11238475 )
2001
14
A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. ( 11238476 )
2001
15
Tc-99m MDP thyroid uptake in a patient with a large nontoxic goiter. ( 11079599 )
2000
16
Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. ( 10690902 )
2000
17
The effect of iodine administration on the development of thyroid autoimmunity in patients with nontoxic goiter. ( 10907993 )
2000
18
Is routine thyroxine treatment to hinder postoperative recurrence of nontoxic goiter justified? ( 10022449 )
1999
19
Postural changes of the cervical spine in patients with nontoxic goiter. ( 9868630 )
1998
20
Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. ( 9284721 )
1997
21
Iodine-131 therapy in sporadic nontoxic goiter. ( 9074521 )
1997
22
Long-term observation of serum thyroglobulin after resection of nontoxic goiter and relation to ultrasonographically demonstrated relapse. ( 8661844 )
1996
23
Improvement of upper airway obstruction after 131I-treatment of multinodular nontoxic goiter evaluated by flow volume loop curves. ( 8778168 )
1996
24
Radioiodine uptake as a function of stored iodine and thyroglobulin in thyroid follicles: in vitro quantitative imaging approach with secondary ion mass spectrometry (SIMS) microscopy in human nontoxic goiter. ( 7920005 )
1994
25
Superior vena cava syndrome due to a substernal nontoxic goiter. ( 8004873 )
1994
26
Bone metabolism in premenopausal women with nontoxic goiter and reduced serum thyrotropin levels. ( 7536445 )
1994
27
Thyroid hormone suppressive therapy of sporadic nontoxic goiter. ( 1422239 )
1992
28
Determinants of outcome in sporadic nontoxic goiter. ( 1284332 )
1992
29
Hypervascularity of nontoxic goiter as shown by color-coded Doppler sonography. ( 1772472 )
1991
30
Bone Gla protein and sex hormone-binding globulin in nontoxic goiter: parameters for metabolic status at the tissue level. ( 2294139 )
1990
31
Interrelationships between age, thyroid volume, thyroid nodularity, and thyroid function in patients with sporadic nontoxic goiter. ( 2239979 )
1990
32
Transforming growth factor beta regulates thyroid growth. Role in the pathogenesis of nontoxic goiter. ( 2921318 )
1989
33
Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease. ( 3130398 )
1988
34
Increased thyroidal T4/T3 ratio in nodular and paranodular tissues of nontoxic goiter following suppressive treatment with thyroid hormones. ( 3570153 )
1987
35
Serum thyroglobulin concentration in nontoxic goiter and response to surgery with special reference to risk of goiter relapse. ( 3092474 )
1986
36
Triiodothyronine suppression of diffuse nontoxic goiter. ( 6470438 )
1984
37
Seasonal variation of stable intrathyroidal iodine in nontoxic goiter disclosed by x-ray fluorescence. ( 7096913 )
1982
38
Serum thyroglobulin in patients undergoing subtotal thyroidectomy for toxic and nontoxic goiter. ( 7108151 )
1982
39
Thyroid blood flow rate in man. Electromagnetic flowmetry during operation in euthyroid normal gland, nontoxic goiter, and hyperthyroidism. ( 6459360 )
1981
40
Endemic and sporadic nontoxic goiter. ( 7033981 )
1981
41
Thyroid uptake on bone scan in a large, multinodular, nontoxic goiter with calcific degeneration. ( 7438651 )
1980
42
Thyroglobulin and calcitonin in patients with nontoxic goiter. ( 702754 )
1978
43
Increased serum thyroglobulin levels in patients with nontoxic goiter. ( 755050 )
1978
44
Different sensitivity of 131I uptake and TRH test during thyroxine treatment of nontoxic goiter. ( 122399 )
1978
45
Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification defect. ( 1165726 )
1975
46
Nontoxic goiter-diffuse or nodular. ( 1174255 )
1975
47
Serum triiodothyronine in simple nontoxic goiter in Sicily. ( 1213666 )
1975
48
Suppressive therapy of nontoxic goiter. ( 4432862 )
1974
49
Thyrotropin response to synthetic thyrotropin-releasing hormone in normal subjects and in patients with nontoxic goiter. ( 4115461 )
1972
50
TSH production rate in nontoxic goiter. ( 5577165 )
1971

Variations for Nontoxic Goiter

Expression for Nontoxic Goiter

Search GEO for disease gene expression data for Nontoxic Goiter.

Pathways for Nontoxic Goiter

GO Terms for Nontoxic Goiter

Cellular components related to Nontoxic Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 BGLAP CALCA FASLG SERPINA7 SHBG TG
2 extracellular space GO:0005615 9.02 BGLAP CALCA FASLG SERPINA7 TPO

Biological processes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.54 CALCA FASLG TSHR
2 positive regulation of cAMP biosynthetic process GO:0030819 9.32 CALCA TSHR
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.26 CALCA TSHR
4 activation of adenylate cyclase activity GO:0007190 9.16 CALCA TSHR
5 hormone biosynthetic process GO:0042446 8.96 TG TPO
6 positive regulation of adenylate cyclase activity GO:0045762 8.62 CALCA TSHR

Sources for Nontoxic Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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