NPH
MCID: NRM002
MIFTS: 50

Normal Pressure Hydrocephalus (NPH) malady

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Normal Pressure Hydrocephalus

About this section
Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 49NINDS, 50Novoseek, 54Orphanet, 62SNOMED-CT, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Normal Pressure Hydrocephalus:

Name: Normal Pressure Hydrocephalus 11 49 54 13
Hydrocephalus, Normal Pressure 39 68
Hydrocephalus - Normal Pressure 49
Hydrocephalus Normal Pressure 50
 
Chronic Adult Hydrocephalus 54
Low Pressure Hydrocephalus 11
Nph 54

Characteristics:

Orphanet epidemiological data:

54
normal pressure hydrocephalus:
Inheritance: Not applicable; Age of onset: Adult


Classifications:



External Ids:

Disease Ontology11 DOID:1572
ICD1030 G91.2
MeSH39 D006850
SNOMED-CT62 30753002, 69663004
Orphanet54 ORPHA314928
UMLS via Orphanet69 C0020258
ICD10 via Orphanet31 G91.2

Summaries for Normal Pressure Hydrocephalus

About this section
NINDS:49 Normal pressure hydrocephalus (NPH) is an abnormal buildup of cerebrospinal fluid (CSF) in the brain's ventricles, or cavities. It occurs if the normal flow of CSF throughout the brain and spinal cord is blocked in some way. This causes the ventricles to enlarge, putting pressure on the brain. Normal pressure hydrocephalus can occur in people of any age, but it is most common in the elderly. It may result from a subarachnoid hemorrhage, head trauma, infection, tumor, or complications of surgery. However, many people develop NPH even when none of these factors are present. In these cases the cause of the disorder is unknown.

MalaCards based summary: Normal Pressure Hydrocephalus, also known as hydrocephalus, normal pressure, is related to hydrocephalus and nephronophthisis, and has symptoms including urinary incontinence, dementia and global developmental delay. An important gene associated with Normal Pressure Hydrocephalus is PMPCA (Peptidase, Mitochondrial Processing Alpha Subunit), and among its related pathways are A-beta Pathways: Uptake and Degradation and A-beta Pathways: Plaque Formation and APP Metabolism. Affiliated tissues include brain, testes and spinal cord, and related mouse phenotypes are nervous system and respiratory system.

Wikipedia:71 Normal pressure hydrocephalus (NPH), also termed Hakim\'s syndrome and symptomatic hydrocephalus, is a... more...

Related Diseases for Normal Pressure Hydrocephalus

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Diseases related to Normal Pressure Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1hydrocephalus11.6
2nephronophthisis11.2
3glomerulosclerosis, focal segmental, 210.9
4nephronophthisis 410.8
5nephronophthisis 1, juvenile10.8
6nephronophthisis 310.8
7nephrotic syndrome, type 110.7
8glomerulosclerosis, focal segmental, 410.7
9glomerulosclerosis, focal segmental, 310.7
10glomerulosclerosis, focal segmental, 510.7
11glomerulosclerosis, focal segmental, 110.7
12cerebritis10.4
13dementia10.3
14cockayne syndrome type i10.2NPY, VIP
15bone dysplasia azouz type10.1APOE, APP, VIP
16ichthyosis lamellar 210.1APOE, APP, PTGDS
17ectodermal dysplasia mental retardation syndactyly10.1APP, PSEN1
18porencephaly 210.1APOE, APP
19urethritis10.1APOE, PSEN1
20pulmonary systemic sclerosis10.1APOE, PTGDS, SERPINA3
21foxp2-related speech and language disorders10.1APP, PSEN1
22anaplastic ependymoma10.0TTR, VIP
23pick disease10.0APP, PSEN1
24intracranial structure hemangioma10.0APP, PSEN1
25severe congenital nemaline myopathy10.0APOE, PSEN1
26allergic bronchopulmonary aspergillosis, familial10.0APOE, APP, SERPINA3
27arthrogryposis, lethal, with anterior horn cell disease10.0APOE, TTR
28alzheimer disease10.0
29cerebral atrophy10.0
30encephalopathy10.0
31cardiomyopathy, dilated, 1v10.0APP, PSEN1
32encephalitozoonosis10.0APOE, APP, PSEN1
33coenzyme q10 deficiency, primary, 110.0APOE, APP, PSEN1
34cardiomyopathy, dilated, 1u10.0APOE, APP, PSEN1
35clear cell adenoma10.0HCRT, PSEN1
36atrial septal defect 99.9APP, HCRT
37personality disorder9.9APOE, HCRT, PSEN1
38eumycotic mycetoma9.9APOE, APP, PSEN1
39arachnoiditis9.9
40hemopericardium9.9NPY, TTR
41syringomyelia9.9
42vascular dementia9.9
43intracranial hypertension9.9
44arachnoid cysts9.9
45subcortical arteriosclerotic encephalopathy9.9
46meckel syndrome 109.8APOE, APP, PSEN1, SERPINA3
47contagious pustular dermatitis9.8APOE, APP, PSEN1, SERPINA3
48van maldergem syndrome 29.8APP, PSEN1, TTR
49schizophrenia9.8
50systemic lupus erythematosus9.8

Graphical network of the top 20 diseases related to Normal Pressure Hydrocephalus:



Diseases related to normal pressure hydrocephalus

Symptoms & Phenotypes for Normal Pressure Hydrocephalus

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Human phenotypes related to Normal Pressure Hydrocephalus:

 64 (show all 6)
id Description HPO Frequency HPO Source Accession
1 urinary incontinence64 HP:0000020
2 dementia64 HP:0000726
3 global developmental delay64 HP:0001263
4 gait disturbance64 HP:0001288
5 normal pressure hydrocephalus64 HP:0002343
6 bowel incontinence64 HP:0002607

MGI Mouse Phenotypes related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.0ADORA2A, APOE, APP, HCRT, NPY, PSEN1
2MP:00053887.8ADORA2A, APOE, HCRT, PSEN1, VIP
3MP:00053867.6ADORA2A, APOE, APP, HCRT, NPY, PSEN1
4MP:00053767.0ADORA2A, APOE, APP, HCRT, NPY, PSEN1

Drugs & Therapeutics for Normal Pressure Hydrocephalus

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Drugs for Normal Pressure Hydrocephalus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
CitalopramapprovedPhase 451259729-33-82771
Synonyms:
1,3-Dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile
1,3-dihydro[3,4]benzofuran-5-carbonitrile
1-(3-(Dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile
59729-33-8
AB00513896
AC-12214
AC1L1EFH
AE-641/00603021
Akarin
BPBio1_000929
BRD-A47598013-004-02-0
BSPBio_000843
Bonitrile
C07572
C20H21FN2O
CHEBI:3723
CHEMBL549
CID2771
CPD000465669
Celapram
Celexa
Celius
Ciazil
Cilift
Cipram
Cipramil
Ciprapine
Citabax
Citadur
Citadur (TN)
Citalec
Citalopram (USP/INN)
Citalopram Hydrobromide
Citalopram [Celexa]
Citalopram [INN:BAN]
Citalopram hydrobromide
Citalopramum
Citalopramum [INN-Latin]
 
Citol
Citopam
Citox
Citrol
Cytalopram
D07704
DB00215
Dalsan
EINECS 261-891-1
Elopram
HMS2090O09
HMS2093A14
Humorup
I01-0382
InChI=1/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3
L001223
LS-84327
Lopac0_000258
Lu 10-171
Lu-10-171
MolPort-003-666-794
NCGC00015267-07
NCGC00025160-02
Nitalapram
Oropram
Pramcit
Prestwick3_000692
Recital
SAM002589960
ST069372
STL058639
Seropram
Talam
Talohexal
Temperax
UNII-0DHU5B8D6V
Vodelax
Zentius
Zetalo
[3H]Citalopram
citalopram
2
SerotoninPhase 4362750-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
3Serotonin AgentsPhase 43156
4Neurotransmitter Uptake InhibitorsPhase 43521
5Cholinergic AgentsPhase 43992
6Serotonin Uptake InhibitorsPhase 41587
7Cholinergic AntagonistsPhase 41706
8Muscarinic AntagonistsPhase 41166
9Neurotransmitter AgentsPhase 418340
10
Acetazolamideapproved, vet_approvedPhase 38059-66-51986
Synonyms:
1424-27-7 (mono-hydrochloride salt)
1yda
1ydb
1ydd
1zsb
2-acetylamino-1,3,4-thiadiazole-5-sulfonamide
2h4n
3czv
4-Diamox
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
5-acetylamino-1,3,4-thiadiazole-2-sulfonamide
5661-25-6
59-66-5
8017-69-4
A 6011
A6011_SIAL
A6011_SIGMA
AB00051906
AC-12779
AC1L1CO5
AI3-52458
AKOS000715163
Acetadiazol
Acetamidothiadiazolesulfonamide
Acetamox
Acetazolam
Acetazolamid
Acetazolamida
Acetazolamida [INN-Spanish]
Acetazolamide (AAZ)
Acetazolamide (JP15/USP/INN)
Acetazolamide Apotex Brand
Acetazolamide Chiesi Brand
Acetazolamide Dioptic Brand
Acetazolamide Grin Brand
Acetazolamide ICN Brand
Acetazolamide Jumer Brand
Acetazolamide Llorens Brand
Acetazolamide Medphano Brand
Acetazolamide Novopharm Brand
Acetazolamide Orion Brand
Acetazolamide Sodium
Acetazolamide Sodium, (Sterile)
Acetazolamide Wassermann Brand
Acetazolamide [INN:BAN:JAN]
Acetazolamide, Monosodium Salt
Acetazolamidum
Acetazolamidum [INN-Latin]
Acetazolamine
Acetazoleamide
Acetozalamide
Acétazolamide
Ak Zol
Ak-Zol
AkZol
Apo Acetazolamide
Apo-Acetazolamide
ApoAcetazolamide
Apotex Brand of Acetazolamide
Atenezol
BAS 01585728
BIDD:GT0643
BPBio1_000007
BSPBio_000005
BSPBio_001788
C06805
C4H6N4O3S2
CAS-59-66-5
CCRIS 5811
CHEBI:27690
CHEMBL20
CID1986
CPD0-1626
CPD000058394
Carbonic Anhydrase Inhibitor 6063
Carbonic Anhydrase Inhibitor No. 6063
Carbonic anhydrase inhibitor 6063
Chiesi Brand of Acetazolamide
Ciba Vision Brand of Acetazolamide
Cidamex
D000086
D00218
DB00819
Dazamide
Defiltran
Dehydratin
Diacarb
Diakarb
Diamox
Diamox (TN)
Diamox Sequels
Didoc
Diluran
 
Dioptic Brand of Acetazolamide
Diuramid
Diuramide
Diureticum-Holzinger
Diureticum-holzinger
Diuriwas
Diutazol
DivK1c_000017
Donmox
Duiramid
EINECS 200-440-5
EU-0100039
Edemox
Eumicton
Fonurit
Glauconox
Glaumox
Glaupax
Glupax
Grin Brand of Acetazolamide
HMS1568A07
HMS1920A05
HMS2091G05
HMS500A19
HSDB 3002
Huma Zolamide
Huma-Zolamide
HumaZolamide
I09-0425
ICN Brand of Acetazolamide
IDI1_000017
Jumer Brand of Acetazolamide
KBio1_000017
KBio2_000358
KBio2_002926
KBio2_005494
KBio3_001288
KBioGR_000558
KBioSS_000358
LS-10227
Llorens Brand of Acetazolamide
Lopac-A-6011
Lopac0_000039
MLS000028435
MLS001148438
Medphano Brand of Acetazolamide
MolPort-001-783-578
Monosodium Salt Acetazolamide
N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide
NCGC00015074-01
NCGC00015074-02
NCGC00015074-03
NCGC00015074-06
NCGC00015074-11
NCGC00023455-03
NCGC00023455-04
NCGC00023455-05
NCGC00023455-06
NCGC00023455-07
NINDS_000017
NSC 145177
NSC145177
Natrionex
Nephramid
Nephramide
Novopharm Brand of Acetazolamide
Orion Brand of Acetazolamide
Phonurit
Prestwick0_000003
Prestwick1_000003
Prestwick2_000003
Prestwick3_000003
Prestwick_4
SAM002554883
SBB056640
SK-acetazolamide
SMR000058394
SPBio_000004
SPBio_001926
SPECTRUM1500102
Sk-Acetazolamide
Spectrum2_000082
Spectrum3_000284
Spectrum4_000139
Spectrum5_000738
Spectrum_000018
Storz Brand of Acetazolamide Preparation
Storzolamide
UNII-O3FX965V0I
Vetamox
WLN: T5NN DSJ CSZW EMV1
Wassermann Brand of Acetazolamide
Wyeth Brand of Acetazolamide Preparation
acetazolamide
11Pharmaceutical SolutionsPhase 2, Phase 38192
12Anti-Infective Agents, LocalPhase 2, Phase 31880
13AnestheticsPhase 2, Phase 39596
14diureticsPhase 31418
15Natriuretic AgentsPhase 31697
16Carbonic Anhydrase InhibitorsPhase 3186
17AnticonvulsantsPhase 32695
18Mitogens1617

Interventional clinical trials:

(show all 42)
idNameStatusNCT IDPhase
1Normal Pressure Hydrocephalus (NPH) RegistryCompletedNCT00233701Phase 4
2Efficacy and Safety of Selective Serotonin Reuptake Inhibitor (SSRI) in Overactive Bladder PatientsCompletedNCT00902421Phase 4
3ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH PatientsCompletedNCT01323764Phase 4
4ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) PatientsWithdrawnNCT00793416Phase 4
5Clinical Value of Noninvasive Intracranial Pressure MeasurementUnknown statusNCT02130219Phase 2, Phase 3
6PET Imaging of Brain Amyloid in Normal Pressure HydrocephalusCompletedNCT01053312Phase 3
7A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System.CompletedNCT00196196Phase 3
8Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure HydrocephalusTerminatedNCT01092546Phase 3
9ETV Versus Shunt Surgery in Normal Pressure HydrocephalusTerminatedNCT00946127Phase 3
10Normal Pressure Hydrocephalus Treatment by AcetazolamideTerminatedNCT02163330Phase 3
11Study to Evaluate Efficacy of Shunt Operation for Idiopathic Normal Pressure HydrocephalusCompletedNCT00221091Phase 2
12Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure HydrocephalusUnknown statusNCT01618500
13European Study on Prediction of Outcome in Patients With Idiopathic Normal Pressure HydrocephalusUnknown statusNCT00874198
14Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral IschemiaUnknown statusNCT00494689
15Magnetic Resonance Elastography in HydrocephalusUnknown statusNCT02230124
16Cerebral Blood Circulation in Patients With Posterior Fossa Brain TumorUnknown statusNCT01476670
17A Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure HydrocephalusCompletedNCT01570257
18Predictive Value of Flow MRI in Normal Pressure Hydrocephalus SurgeryCompletedNCT01815775Early Phase 1
19Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure HydrocephalusCompletedNCT00600795
20Computerized Neuropsychology in Idiopathic Normal Pressure Hydrocephalus (INPH)CompletedNCT01265251
21A Study Comparing Shunt Placement Versus Endoscopic Third Ventriculostomy in the Treatment of HydrocephalusCompletedNCT01115270
22Vascular Risk Factors in INPH-patientsCompletedNCT01850914
23Cerebrospinal Fluid Proteome in HydrocephalusCompletedNCT02016352
24Improved Analysis Methods for Infusion TestsCompletedNCT01319136
25Intracranial Pressure Waves Via Lumbar PunctureCompletedNCT01374048
26Value of Radionuclide CisternographyCompletedNCT02876614
27Comparison of Continuous Noninvasive and Invasive Intracranial Pressure Measurement--Celda Infusion SubprotocolCompletedNCT01976559
28Reference Values of Cerebrospinal Fluid Outflow Resistance and Intracranial Pressure in Healthy ElderlyCompletedNCT01188382
29Establishing the Physiology of SyringomyeliaCompletedNCT00001327
30The Brain Structure and Neural Network Changing the Before and After Ventriculo-peritoneal Shunting in the Normal Pressure Hydrocephalus PatientsRecruitingNCT03092804
31Flow MRI in Normal Pressure HydrocephalusRecruitingNCT01909960
32Effects of Physical Training in iNPHRecruitingNCT02659111
33A Randomized Cross-over Study for Normal Pressure HydrocephalusRecruitingNCT01798641
34Novel Parameters for the Prediction of Ventriculoperitoneal Shunting Efficacy in Patients With iNPHRecruitingNCT02495610
35Noninvasive Intracranial Pressure and Hydrocephalus PatientsEnrolling by invitationNCT02404740
36Using Cerebrospinal Fluid Dynamics to Optimize Treatment of Idiopathic Normal Pressure HydrocephalusNot yet recruitingNCT03076723
37An Evaluation of Non-Invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an Intraparenchymal Pressure Monitoring DeviceSuspendedNCT02773888
38Factors Predicting Response to Shunting in Normal Pressure HydrocephalusTerminatedNCT00613886
39Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus (INPH)TerminatedNCT00727142
40Anterior Pituitary Function in Patients With HydrocephalusTerminatedNCT00149721
41Prognostic Value of Aβ Imaging in NPH Prior to Shunt PlacementTerminatedNCT01834625
42Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in LifeWithdrawnNCT01377805

Search NIH Clinical Center for Normal Pressure Hydrocephalus


Cochrane evidence based reviews: hydrocephalus, normal pressure

Genetic Tests for Normal Pressure Hydrocephalus

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Anatomical Context for Normal Pressure Hydrocephalus

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MalaCards organs/tissues related to Normal Pressure Hydrocephalus:

36
Brain, Testes, Spinal cord, Thalamus, Pituitary, Olfactory bulb, Bone

Publications for Normal Pressure Hydrocephalus

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Articles related to Normal Pressure Hydrocephalus:

(show top 50)    (show all 631)
idTitleAuthorsYear
1
Clinical Correlation of Abnormal Findings on Magnetic Resonance Elastography in Idiopathic Normal Pressure Hydrocephalus. (28063896)
2017
2
Decreased Expression of hsa-miR-4274 inA Cerebrospinal Fluid of Normal Pressure Hydrocephalus Mimics with Parkinsonian Syndromes. (27911315)
2017
3
The clinical effect of postoperative hyperbaric oxygen therapy on idiopathic normal pressure hydrocephalus:A retrospective and comparative analysis of 61 patients with ventriculoperitoneal shunt. (28502690)
2017
4
Supplementary tests in idiopathic normal pressure hydrocephalus: a single center experience with a combined lumbar infusion test and tap test. (28089835)
2017
5
Asymmetric and Upper-Body Parkinsonism in Patients with Idiopathic Normal-Pressure Hydrocephalus. (28516741)
2017
6
Spectral Domain-Optical Coherence Tomography As a New Diagnostic Marker for Idiopathic Normal Pressure Hydrocephalus. (28507532)
2017
7
Neurite orientation dispersion and density imaging for evaluation of corticospinal tract in idiopathic normal pressure hydrocephalus. (27787666)
2017
8
Diagnosis of Normal-Pressure Hydrocephalus: Use of Traditional Measures in the Era of Volumetric MR Imaging. (28498794)
2017
9
Olfactory ability in normal pressure hydrocephalus as compared to Alzheimer's disease and healthy controls. (28017216)
2017
10
Cerebrospinal fluid AI^42, t-tau, and p-tau levels in the differential diagnosis of idiopathic normal-pressure hydrocephalus: a systematic review and meta-analysis. (28486988)
2017
11
Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-I^ Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. (27802227)
2017
12
Associations of intracranial pressure with brain biopsy, radiological findings, and shunt surgery outcome in patients with suspected idiopathic normal pressure hydrocephalus. (27878614)
2017
13
Timing of surgical treatment for idiopathic normal pressure hydrocephalus: association between treatment delay and reduced short-term benefit. (27581314)
2016
14
The Prediction of Shunt Response in Idiopathic Normal-Pressure Hydrocephalus Based on Intracranial Pressure Monitoring and Lumbar Infusion. (27165919)
2016
15
Clinical outcomes in the surgical treatment of idiopathic normal pressure hydrocephalus. (26935749)
2016
16
The effect of shunt surgery on neuropsychological performance in normal pressure hydrocephalus: a systematic review and meta-analysis. (27017344)
2016
17
Choroidal fissure acts as an overflow device in cerebrospinal fluid drainage: morphological comparison between idiopathic and secondary normal-pressure hydrocephalus. (27941913)
2016
18
The Effect of Spinal Tap Test on Different Sensory Modalities of Postural Stability in Idiopathic Normal Pressure Hydrocephalus. (27790243)
2016
19
Typical Symptoms of Normal-Pressure Hydrocephalus Caused by Choroid Plexus Papilloma in the Cerebellopontine Angle. (27913261)
2016
20
Normal pressure hydrocephalus and parkinsonism: preliminary data on neurosurgical and neurological treatment. (26970480)
2016
21
NPH Log: Validation of a New Assessment Tool Leading to Earlier Diagnosis of Normal Pressure Hydrocephalus. (27489752)
2016
22
Neurosyphilis With Normal Pressure Hydrocephalus and Dementia Paralytica: Serial Clinical, Laboratory and Radiological Correlations in the 21st Century. (27761229)
2016
23
Magnetic Resonance Imaging of Normal Pressure Hydrocephalus. (27063662)
2016
24
Imaging normal pressure hydrocephalus: theories, techniques, and challenges. (27581307)
2016
25
Relative Position of the Third Characteristic Peak of the Intracranial Pressure Pulse Waveform Morphology Differentiates Normal-Pressure Hydrocephalus Shunt Responders and Nonresponders. (27165933)
2016
26
Disappearance of the Hummingbird Sign after Shunt Surgery in a Case of Idiopathic Normal Pressure Hydrocephalus. (27041171)
2016
27
Characterization of lower urinary tract symptoms in patients with idiopathic normal pressure hydrocephalus. (27490149)
2016
28
Longitudinal Metabolite Profiling of Cerebrospinal Fluid in Normal Pressure Hydrocephalus Links Brain Metabolism with Exercise-Induced VEGF Production and Clinical Outcome. (27084769)
2016
29
Familial idiopathic normal pressure hydrocephalus. (27538594)
2016
30
Relationship between intracranial pressure and phase contrast cine MRI derived measures of intracranial pulsations in idiopathic normal pressure hydrocephalus. (27519145)
2016
31
Normal-Pressure Hydrocephalus Case Report: Self-Documented Over 8 Years with the Author's Observations. (27165936)
2016
32
Diagnosis and Treatment of Idiopathic Normal Pressure Hydrocephalus. (27042909)
2016
33
Measuring changes in the optic nerve sheath diameter in patients with idiopathic normal-pressure hydrocephalus: a useful diagnostic supplement to spinal tap tests. (27981690)
2016
34
Apathy and higher level of gait control in normal pressure hydrocephalus. (27965058)
2016
35
Normal pressure hydrocephalus: Increase of utricular input in responders to spinal tap test. (27072102)
2016
36
Executive functioning pattern as a prognostic indicator for shunt implantation surgery in patients with normal pressure hydrocephalus - A preliminary report. (26969565)
2016
37
Diagnostic ability of cerebrospinal fluid tap test for predicting shunt responsiveness in patients with normal pressure hydrocephalus. (27772746)
2016
38
Investigation and clinical applications of muscle strength change in cerebrospinal fluid tap test in cases of idiopathic normal pressure hydrocephalus: A retrospective study. (27871440)
2016
39
Walking assessment after lumbar puncture in normal-pressure hydrocephalus: a delayed improvement over 3 days. (26991388)
2016
40
Surgical management of idiopathic normal pressure hydrocephalus: a trial of a trial. (27626959)
2016
41
Assessment of response to cerebrospinal fluid tap test for normal pressure hydrocephalus: how we do it. (27530884)
2016
42
Asymmetric and Upper Body Parkinsonism in Patients with Idiopathic Normal-Pressure Hydrocephalus. (27486933)
2016
43
Early and delayed assessments of quantitative gait measures to improve the tap test as a predictor of shunt effectiveness in idiopathic normal pressure hydrocephalus. (27876063)
2016
44
Bulbar dysfunction in normal pressure hydrocephalus: a prospective study. (27581311)
2016
45
Disproportionately Enlarged Subarachnoid Space Hydrocephalus in Idiopathic Normal-Pressure Hydrocephalus and Its Implication in Pathogenesis. (27165923)
2016
46
Early Idiopathic Normal Pressure Hydrocephalus Patients With Neuropsychological Impairment Are Associated With Increased Fractional Anisotropy in the Anterior Thalamic Nucleus. (27175677)
2016
47
Efficacy of Lumboperitoneal Shunting in Patients with Normal Pressure Hydrocephalus. (27858384)
2016
48
Segmentation and labeling of the ventricular system in normal pressure hydrocephalus using patch-based tissue classification and multi-atlas labeling. (27199501)
2016
49
Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus. (27743250)
2016
50
Cerebrospinal fluid levels of tumor necrosis factor alpha and aquaporin 1 in patients with mild cognitive impairment and idiopathic normal pressure hydrocephalus. (27155076)
2016

Variations for Normal Pressure Hydrocephalus

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Clinvar genetic disease variations for Normal Pressure Hydrocephalus:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PMPCANM_ 015160.2(PMPCA): c.1129G> A (p.Ala377Thr)SNVPathogenicrs753611141GRCh38Chr 9, 136418847: 136418847
2PMPCANM_ 015160.2(PMPCA): c.1066G> A (p.Gly356Ser)SNVPathogenicrs768643552GRCh37Chr 9, 139313082: 139313082

Expression for genes affiliated with Normal Pressure Hydrocephalus

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Search GEO for disease gene expression data for Normal Pressure Hydrocephalus.

Pathways for genes affiliated with Normal Pressure Hydrocephalus

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Pathways related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7APOE, APP
29.2APP, PSEN1
38.9APOE, APP, PSEN1
47.7APOE, APP, HCRT, NPY, PSEN1, VIP

GO Terms for genes affiliated with Normal Pressure Hydrocephalus

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Cellular components related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ciliary rootletGO:003525310.0APP, PSEN1
2dendritic shaftGO:004319810.0APP, PSEN1
3smooth endoplasmic reticulumGO:00057909.2APP, PSEN1
4perinuclear region of cytoplasmGO:00484719.1APP, HCRT, PSEN1, PTGDS
5rough endoplasmic reticulumGO:00057919.0APP, HCRT, PSEN1, PTGDS
6Golgi apparatusGO:00057948.9APOE, APP, NPY, PSEN1, PTGDS
7extracellular spaceGO:00056158.5APOE, APP, NPY, PMPCA, PTGDS, SERPINA3
8extracellular regionGO:00055768.0APOE, APP, HCRT, NPY, PTGDS, SERPINA3

Biological processes related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:000763110.5HCRT, NPY
2blood circulationGO:000801510.2ADORA2A, NPY
3eating behaviorGO:004275510.2ADORA2A, HCRT
4protein kinase C-activating G-protein coupled receptor signaling pathwayGO:000720510.1ADORA2A, HCRT
5amyloid precursor protein metabolic processGO:004298210.0APOE, PSEN1
6positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:00105799.9ADORA2A, VIP
7astrocyte activation involved in immune responseGO:00022659.9APP, PSEN1
8cellular response to beta-amyloidGO:19046469.9APP, PSEN1
9positive regulation of dendritic spine developmentGO:00609999.9APOE, PSEN1
10neuron apoptotic processGO:00514029.9APP, PSEN1
11regulation of epidermal growth factor-activated receptor activityGO:00071769.8APP, PSEN1
12synaptic transmission, cholinergicGO:00072719.8ADORA2A, APOE
13regulation of protein bindingGO:00433939.8APP, PSEN1
14smooth endoplasmic reticulum calcium ion homeostasisGO:00515639.7APP, PSEN1
15vasodilationGO:00423119.5ADORA2A, APOE
16response to oxidative stressGO:00069799.3APOE, APP, PSEN1
17negative regulation of neuron apoptotic processGO:00435249.3ADORA2A, APOE, PSEN1
18regulation of synaptic plasticityGO:00481679.2ADORA2A, APP, PSEN1
19cellular protein metabolic processGO:00442678.4ADORA2A, APOE, APP, PSEN1, TTR

Molecular functions related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.5NPY, TTR, VIP
2neuropeptide hormone activityGO:00051849.3HCRT, NPY, VIP

Sources for Normal Pressure Hydrocephalus

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet