MCID: NRM002
MIFTS: 49

Normal Pressure Hydrocephalus malady

Neuronal diseases, Rare diseases categories

Aliases & Classifications for Normal Pressure Hydrocephalus

About this section
Sources:
10Disease Ontology, 46NINDS, 12DISEASES, 51Orphanet, 47Novoseek, 65UMLS, 36MeSH, 59SNOMED-CT, 28ICD10 via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Normal Pressure Hydrocephalus:

Name: Normal Pressure Hydrocephalus 10 46 12 51
Hydrocephalus, Normal Pressure 65 36
Hydrocephalus - Normal Pressure 46
Hydrocephalus Normal Pressure 47
 
Chronic Adult Hydrocephalus 51
Low Pressure Hydrocephalus 10
Nph 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
normal pressure hydrocephalus:
Inheritance: Not applicable; Age of onset: Adult


External Ids:

Disease Ontology10 DOID:1572
MeSH36 D006850
Orphanet51 314928
SNOMED-CT59 69663004, 30753002
ICD10 via Orphanet28 G91.2
UMLS via Orphanet66 C0020258
ICD1027 G91.2

Summaries for Normal Pressure Hydrocephalus

About this section
NINDS:46 Normal pressure hydrocephalus (NPH) is an abnormal buildup of cerebrospinal fluid (CSF) in the brain's ventricles, or cavities. It occurs if the normal flow of CSF throughout the brain and spinal cord is blocked in some way. This causes the ventricles to enlarge, putting pressure on the brain. Normal pressure hydrocephalus can occur in people of any age, but it is most common in the elderly. It may result from a subarachnoid hemorrhage, head trauma, infection, tumor, or complications of surgery. However, many people develop NPH even when none of these factors are present. In these cases the cause of the disorder is unknown.

MalaCards based summary: Normal Pressure Hydrocephalus, also known as hydrocephalus, normal pressure, is related to diabetes mellitus, noninsulin-dependent and pick disease, and has symptoms including autosomal recessive inheritance, urinary incontinence and dementia. An important gene associated with Normal Pressure Hydrocephalus is PTGDS (Prostaglandin D2 Synthase 21kDa (Brain)), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and A-beta Uptake and Degradation. Affiliated tissues include brain, testes and spinal cord, and related mouse phenotypes are other and muscle.

Wikipedia:68 Normal pressure hydrocephalus (NPH), also termed symptomatic hydrocephalus, is a type of brain... more...

Related Diseases for Normal Pressure Hydrocephalus

About this section

Diseases related to Normal Pressure Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus, noninsulin-dependent30.5APOE, NPY, PYY, SST
2pick disease30.5APOE, APP, PSEN1
3alzheimer disease29.9APOE, APP, CLU, PSEN1, SERPINA3
4hydrocephalus11.5
5cerebritis10.9
6dementia10.8
7intracranial hypertension10.8
8diabetes mellitus, insulin-dependent10.7
9glucose metabolism disease10.7
10mody, type ii10.6
11diabetes mellitus, noninsulin-dependent, 210.6
12hypoglycemia10.6
13encephalopathy10.6
14diabetes mellitus, noninsulin-dependent 110.6
15cerebral atrophy10.5
16diabetes mellitus, ketosis-prone10.5
17autoimmune disease 110.5
18autoimmune disease of endocrine system10.5
19hemoglobin c disease10.4
20diabetes mellitus, insulin-dependent, 310.4
21fasting hypoglycemia10.4
22autoimmune disease 310.4
23stroke, ischemic10.4
24arachnoiditis10.4
25pseudotumor cerebri10.4
26syringomyelia10.4
27gait apraxia10.4
28apraxia10.4
29ischemia10.4
30arachnoid cysts10.4
31subcortical arteriosclerotic encephalopathy10.4
32diabetes mellitus, insulin-dependent, 2410.3
33autoimmune disease of blood10.3
34skin tag10.3
35carbohydrate metabolic disorder10.3
36schizophrenia10.3
37systemic lupus erythematosus10.3
38coronary heart disease 510.3
39huntington disease10.3
40coronary heart disease 710.3
41mitral valve insufficiency10.3
42ocular hypertension10.3
43neuronitis10.3
44vascular dementia10.3
45adjustment disorder10.3
46adrenal cortex disease10.3
47cerebrovascular disease10.3
48communicating hydrocephalus10.3
49lupus erythematosus10.3
50peritonitis10.3

Graphical network of the top 20 diseases related to Normal Pressure Hydrocephalus:



Diseases related to normal pressure hydrocephalus

Symptoms for Normal Pressure Hydrocephalus

About this section

HPO human phenotypes related to Normal Pressure Hydrocephalus:

(show all 7)
id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 urinary incontinence HP:0000020
3 dementia HP:0000726
4 global developmental delay HP:0001263
5 gait disturbance HP:0001288
6 normal pressure hydrocephalus HP:0002343
7 bowel incontinence HP:0002607

Drugs & Therapeutics for Normal Pressure Hydrocephalus

About this section

Drugs for Normal Pressure Hydrocephalus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
CitalopramapprovedPhase 448559729-33-82771
Synonyms:
1,3-Dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile
1,3-dihydro[3,4]benzofuran-5-carbonitrile
1-(3-(Dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile
59729-33-8
AB00513896
AC-12214
AC1L1EFH
AE-641/00603021
Akarin
BPBio1_000929
BRD-A47598013-004-02-0
BSPBio_000843
Bonitrile
C07572
C20H21FN2O
CHEBI:3723
CHEMBL549
CID2771
CPD000465669
Celapram
Celexa
Celius
Ciazil
Cilift
Cipram
Cipramil
Ciprapine
Citabax
Citadur
Citadur (TN)
Citalec
Citalopram
Citalopram (USP/INN)
Citalopram Hydrobromide
Citalopram [Celexa]
Citalopram [INN:BAN]
Citalopram hydrobromide
Citalopramum
Citalopramum [INN-Latin]
 
Citol
Citopam
Citox
Citrol
Cytalopram
D07704
DB00215
Dalsan
EINECS 261-891-1
Elopram
HMS2090O09
HMS2093A14
Humorup
I01-0382
InChI=1/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3
L001223
LS-84327
Lopac0_000258
Lu 10-171
Lu-10-171
MolPort-003-666-794
NCGC00015267-07
NCGC00025160-02
Nitalapram
Oropram
Perrigo Citalopram
Pramcit
Prestwick3_000692
Recital
SAM002589960
ST069372
STL058639
Seropram
Talam
Talohexal
Temperax
UNII-0DHU5B8D6V
Vodelax
Zentius
Zetalo
[3H]Citalopram
citalopram
2
SerotoninPhase 4285350-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
3
AcetazolamideapprovedPhase 36159-66-51986
Synonyms:
1424-27-7 (mono-hydrochloride salt)
1yda
1ydb
1ydd
1zsb
2-acetylamino-1,3,4-Thiadiazole-5-sulfonamide
2h4n
3czv
4-Diamox
5-ACETAMIDO-1,3,4-thiadiazole-2-sulfonamide
5-acetylamino-1,3,4-Thiadiazole-2-sulfonamide
5661-25-6
59-66-5
8017-69-4
A 6011
A6011_SIAL
A6011_SIGMA
AB00051906
AC-12779
AC1L1CO5
AI3-52458
AKOS000715163
Acetadiazol
Acetamidothiadiazolesulfonamide
Acetamox
Acetazolam
Acetazolamid
Acetazolamida
Acetazolamida [INN-Spanish]
Acetazolamide
Acetazolamide (AAZ)
Acetazolamide (JP15/USP/INN)
Acetazolamide Apotex Brand
Acetazolamide Chiesi Brand
Acetazolamide Dioptic Brand
Acetazolamide Grin Brand
Acetazolamide ICN Brand
Acetazolamide Jumer Brand
Acetazolamide Llorens Brand
Acetazolamide Medphano Brand
Acetazolamide Novopharm Brand
Acetazolamide Orion Brand
Acetazolamide Sodium
Acetazolamide Sodium, (Sterile)
Acetazolamide Wassermann Brand
Acetazolamide [INN:BAN:JAN]
Acetazolamide, Monosodium Salt
Acetazolamidum
Acetazolamidum [INN-Latin]
Acetazolamine
Acetazoleamide
Acetozalamide
Acétazolamide
Ak Zol
Ak-Zol
AkZol
Apo Acetazolamide
Apo-Acetazolamide
ApoAcetazolamide
Apotex Brand of Acetazolamide
Atenezol
Avva
BAS 01585728
BIDD:GT0643
BPBio1_000007
BSPBio_000005
BSPBio_001788
C06805
C4H6N4O3S2
CAS-59-66-5
CCRIS 5811
CHEBI:27690
CHEMBL20
CID1986
CPD0-1626
CPD000058394
Carbonic Anhydrase Inhibitor 6063
Carbonic Anhydrase Inhibitor No. 6063
Carbonic anhydrase inhibitor 6063
Chiesi Brand of Acetazolamide
Ciba Vision Brand of Acetazolamide
Cidamex
D000086
D00218
DB00819
Dazamide
Defiltran
Dehydratin
Diacarb
Diakarb
Diamox
Diamox (TN)
Diamox Sequels
Didoc
 
Diluran
Dioptic Brand of Acetazolamide
Diuramid
Diuramide
Diureticum-Holzinger
Diureticum-holzinger
Diuriwas
Diutazol
DivK1c_000017
Donmox
Duiramid
EINECS 200-440-5
EU-0100039
Edemox
Eumicton
Fonurit
Glauconox
Glaumox
Glaupax
Glupax
Grin Brand of Acetazolamide
HMS1568A07
HMS1920A05
HMS2091G05
HMS500A19
HSDB 3002
Huma Zolamide
Huma-Zolamide
HumaZolamide
I09-0425
ICN Brand of Acetazolamide
IDI1_000017
Jumer Brand of Acetazolamide
KBio1_000017
KBio2_000358
KBio2_002926
KBio2_005494
KBio3_001288
KBioGR_000558
KBioSS_000358
LS-10227
Llorens Brand of Acetazolamide
Lopac-A-6011
Lopac0_000039
MLS000028435
MLS001148438
Medphano Brand of Acetazolamide
MolPort-001-783-578
Monosodium Salt Acetazolamide
N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
N-[5-(Aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide
NCGC00015074-01
NCGC00015074-02
NCGC00015074-03
NCGC00015074-06
NCGC00015074-11
NCGC00023455-03
NCGC00023455-04
NCGC00023455-05
NCGC00023455-06
NCGC00023455-07
NINDS_000017
NSC 145177
NSC145177
Natrionex
Nephramid
Nephramide
Novopharm Brand of Acetazolamide
Orion Brand of Acetazolamide
Phonurit
Prestwick0_000003
Prestwick1_000003
Prestwick2_000003
Prestwick3_000003
Prestwick_4
SAM002554883
SBB056640
SK-acetazolamide
SMR000058394
SPBio_000004
SPBio_001926
SPECTRUM1500102
Sk-Acetazolamide
Spectrum2_000082
Spectrum3_000284
Spectrum4_000139
Spectrum5_000738
Spectrum_000018
Storz Brand of Acetazolamide Preparation
Storzolamide
UNII-O3FX965V0I
Vetamox
WLN: T5NN DSJ CSZW EMV1
Wassermann Brand of Acetazolamide
Wyeth Brand of Acetazolamide Preparation
acetazolamide

Interventional clinical trials:

(show all 38)
idNameStatusNCT IDPhase
1Normal Pressure Hydrocephalus (NPH) RegistryCompletedNCT00233701Phase 4
2ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH PatientsCompletedNCT01323764Phase 4
3Efficacy and Safety of Selective Serotonin Reuptake Inhibitor (SSRI) in Overactive Bladder PatientsCompletedNCT00902421Phase 4
4ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) PatientsWithdrawnNCT00793416Phase 4
5PET Imaging of Brain Amyloid in Normal Pressure HydrocephalusCompletedNCT01053312Phase 3
6A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System.CompletedNCT00196196Phase 3
7Clinical Value of Noninvasive Intracranial Pressure MeasurementRecruitingNCT02130219Phase 2, Phase 3
8Normal Pressure Hydrocephalus Treatment by AcetazolamideNot yet recruitingNCT02163330Phase 3
9Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure HydrocephalusTerminatedNCT01092546Phase 3
10ETV Versus Shunt Surgery in Normal Pressure HydrocephalusTerminatedNCT00946127Phase 3
11Study to Evaluate Efficacy of Shunt Operation for Idiopathic Normal Pressure HydrocephalusCompletedNCT00221091Phase 2
12A Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure HydrocephalusCompletedNCT01570257
13Predictive Value of Flow MRI in Normal Pressure Hydrocephalus SurgeryCompletedNCT01815775Phase 0
14Computerized Neuropsychology in Idiopathic Normal Pressure Hydrocephalus (INPH)CompletedNCT01265251
15Vascular Risk Factors in INPH-patientsCompletedNCT01850914
16Improved Analysis Methods for Infusion TestsCompletedNCT01319136
17Intracranial Pressure Waves Via Lumbar PunctureCompletedNCT01374048
18Comparison of Continuous Noninvasive and Invasive Intracranial Pressure Measurement--Celda Infusion SubprotocolCompletedNCT01976559
19Establishing the Physiology of SyringomyeliaCompletedNCT00001327
20Reference Values of Cerebrospinal Fluid Outflow Resistance and Intracranial Pressure in Healthy ElderlyCompletedNCT01188382
21Flow MRI in Normal Pressure HydrocephalusRecruitingNCT01909960
22Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure HydrocephalusRecruitingNCT01618500
23Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure HydrocephalusRecruitingNCT00600795
24A Randomized Cross-over Study for Normal Pressure HydrocephalusRecruitingNCT01798641
25A Study Comparing Shunt Placement Versus Endoscopic Third Ventriculostomy in the Treatment of HydrocephalusRecruitingNCT01115270
26Novel Parameters for the Prediction of Ventriculoperitoneal Shunting Efficacy in Patients With iNPHRecruitingNCT02495610
27Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral IschemiaRecruitingNCT00494689
28Prognostic Value of Aβ Imaging in NPH Prior to Shunt PlacementRecruitingNCT01834625Phase 0
29Magnetic Resonance Elastography in HydrocephalusRecruitingNCT02230124
30European Study on Prediction of Outcome in Patients With Idiopathic Normal Pressure HydrocephalusActive, not recruitingNCT00874198
31Cerebrospinal Fluid Proteome in HydrocephalusActive, not recruitingNCT02016352
32Noninvasive Intracranial Pressure and Hydrocephalus PatientsEnrolling by invitationNCT02404740
33Effects of Physical Training in iNPHNot yet recruitingNCT02659111
34Cerebral Blood Circulation in Patients With Posterior Fossa Brain TumorNot yet recruitingNCT01476670
35Factors Predicting Response to Shunting in Normal Pressure HydrocephalusTerminatedNCT00613886
36Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus (INPH)TerminatedNCT00727142
37Anterior Pituitary Function in Patients With HydrocephalusTerminatedNCT00149721
38Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in LifeWithdrawnNCT01377805

Search NIH Clinical Center for Normal Pressure Hydrocephalus


Cochrane evidence based reviews: Hydrocephalus, Normal Pressure

Genetic Tests for Normal Pressure Hydrocephalus

About this section

Anatomical Context for Normal Pressure Hydrocephalus

About this section

MalaCards organs/tissues related to Normal Pressure Hydrocephalus:

33
Brain, Testes, Spinal cord, Thalamus, Pituitary, Olfactory bulb, Bone

Animal Models for Normal Pressure Hydrocephalus or affiliated genes

About this section

MGI Mouse Phenotypes related to Normal Pressure Hydrocephalus:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.4APOE, APP, CLU, PSEN1
2MP:00053698.1APOE, APP, CLU, HCRT, PSEN1
3MP:00028738.0APP, NPY, PSEN1, PYY, SST, VIP
4MP:00053787.5APOE, APP, HCRT, NPY, PSEN1, PYY
5MP:00053876.9APOE, APP, CLU, PSEN1, PTGDS, SST
6MP:00053866.7APOE, APP, HCRT, NPY, PSEN1, PTGDS
7MP:00036316.4APOE, APP, CLU, HCRT, NPY, PSEN1
8MP:00053765.5APOE, APP, CLU, HCRT, NPY, PSEN1

Publications for Normal Pressure Hydrocephalus

About this section

Articles related to Normal Pressure Hydrocephalus:

(show top 50)    (show all 561)
idTitleAuthorsYear
1
Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus. (26295919)
2015
2
Optimized surgical treatment for normal pressure hydrocephalus: comparison between gravitational and differential pressure valves. (25666108)
2015
3
Risk of idiopathic normal pressure hydrocephalus in older inpatients with schizophrenia. (26555031)
2015
4
Symptoms of Depression Are Common in Patients With Idiopathic Normal Pressure Hydrocephalus. (26528670)
2015
5
Dynamic state of water molecular displacement of the brain during the cardiac cycle in idiopathic normal pressure hydrocephalus. (25614094)
2015
6
DTI-MRI biomarkers in the search for normal pressure hydrocephalus aetiology: a review. (25345377)
2014
7
CSF dynamic analysis of a predictive pulsatility-based infusion test for normal pressure hydrocephalus. (24151060)
2014
8
Journal club: role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial. (24141398)
2013
9
Normal pressure hydrocephalus in the spectrum of neurological complications of systemic lupus erythematosus. (22829132)
2013
10
Normal pressure hydrocephalus mimicking Alzheimer's disease: such an infrequent case? (23863346)
2013
11
Design and benchmark testing of a bicorporal pump for the treatment of normal-pressure hydrocephalus and idiopathic intracranial hypertension. (23215632)
2013
12
Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus. (23037817)
2013
13
Assessment of a quick reference table algorithm for determining initial postoperative pressure settings of programmable pressure valves in patients with idiopathic normal pressure hydrocephalus: SINPHONI subanalysis. (22653392)
2012
14
The CSF tap test in normal pressure hydrocephalus: evaluation time, reliability and the influence of pain. (21801282)
2012
15
Lumboperitoneal shunts for the treatment of normal pressure hydrocephalus. (22705135)
2012
16
Secondary normal pressure hydrocephalus in a patient with isolated frontal dilatation--an insight into pathophysiology? (22083852)
2012
17
White matter involvement in idiopathic normal pressure hydrocephalus: a voxel-based diffusion tensor imaging study. (21512742)
2011
18
Normal pressure hydrocephalus: measure twice, shunt once. (21849649)
2011
19
Is the midbrain involved in the manifestation of gait disturbance in idiopathic normal-pressure hydrocephalus? (21132323)
2011
20
Potential placebo effect in assessing idiopathic normal pressure hydrocephalus. (21250799)
2011
21
Normal pressure hydrocephalus after gamma knife radiosurgery for vestibular schwannoma. (20739769)
2010
22
Normal-pressure hydrocephalus and cerebral blood flow. (20367076)
2010
23
CSF neurotransmitter metabolites and neuropsychiatric symptomatology in patients with normal pressure hydrocephalus. (19046799)
2009
24
Normal pressure hydrocephalus after radiosurgery for sphenoid ridge meningioma. (19013812)
2009
25
Morphologic features and flow void phenomenon in normal pressure hydrocephalus and other dementias: are they really significant? (19717316)
2009
26
Cerebrospinal fluid drainage and dynamics in the diagnosis of normal pressure hydrocephalus. (19404152)
2009
27
Idiopathic normal pressure hydrocephalus: thoughts on etiology and pathophysiology. (19640656)
2009
28
Normal pressure hydrocephalus or neuroborreliosis? (19225737)
2009
29
Idiopathic normal pressure hydrocephalus: increased supplementary motor activity accounts for improvement after CSF drainage. (18931387)
2008
30
Idiopathic normal pressure hydrocephalus: new findings and thoughts on etiology. (18192342)
2008
31
Sensitivity and predictive value of occupational and physical therapy assessments in the functional evaluation of patients with suspected normal pressure hydrocephalus. (18843422)
2008
32
Gait disturbance in normal pressure hydrocephalus: a clinical study. (17052947)
2007
33
Cerebrospinal fluid tau, phospho-tau181 and beta-amyloid1-42 in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's disease. (17250725)
2007
34
Noninvasive MRI assessment of intracranial compliance in idiopathic normal pressure hydrocephalus. (17610284)
2007
35
Intracranial pressure parameters in idiopathic normal pressure hydrocephalus patients with or without improvement of cognitive function after shunt treatment. (17077633)
2007
36
Proton magnetic resonance spectroscopy in patients with normal pressure hydrocephalus. (24351260)
2006
37
Normal pressure hydrocephalus. (16913194)
2006
38
Normal pressure hydrocephalus: dementia's hidden cause. (16862055)
2006
39
Is it possible to optimize treatment of patients with idiopathic normal pressure hydrocephalus by implanting an adjustable Medos Hakim valve in combination with a Miethke shunt assistant? (16671490)
2006
40
Polyneuropathy complicating the diagnosis of normal pressure hydrocephalus: case report and review of literature. (17100034)
2006
41
Clinical outcome of patients with idiopathic normal pressure hydrocephalus three years after shunt implantation. (16671489)
2006
42
Broadening a classic clinical triad: The hypokinetic motor disorder of normal pressure hydrocephalus also affects the hand. (16375891)
2006
43
Baseline neuropsychological profile and cognitive response to cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus. (16020945)
2005
44
The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus. (16160426)
2005
45
Pulse wave encephalopathy: a spectrum hypothesis incorporating Alzheimer's disease, vascular dementia and normal pressure hydrocephalus. (14962623)
2004
46
Changes in cerebral blood flow during cerebrospinal fluid pressure manipulation in patients with normal pressure hydrocephalus: a methodological study. (15129190)
2004
47
Is a combination of Tc-SPECT or perfusion weighted magnetic resonance imaging with spinal tap test helpful in the diagnosis of normal pressure hydrocephalus? (12640067)
2003
48
Clinical experiences with different valve systems in patients with normal-pressure hydrocephalus: evaluation of the Miethke dual-switch valve. (12172931)
2002
49
Shunt related changes in somatostatin, neuropeptide Y, and corticotropin releasing factor concentrations in patients with normal pressure hydrocephalus. (11181849)
2001
50
Persistence of intraventricular air after pneumoencephalography: its failure to distinguish between cerebral atrophy and normal pressure hydrocephalus. (1226627)
1975

Variations for Normal Pressure Hydrocephalus

About this section

Expression for genes affiliated with Normal Pressure Hydrocephalus

About this section
Search GEO for disease gene expression data for Normal Pressure Hydrocephalus.

Pathways for genes affiliated with Normal Pressure Hydrocephalus

About this section

Pathways related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NPY, PYY
29.5APOE, APP
39.3APP, PSEN1
49.0APOE, APP, PSEN1
58.7APOE, APP, NPY, PSEN1

GO Terms for genes affiliated with Normal Pressure Hydrocephalus

About this section

Cellular components related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendritic shaftGO:00431989.9APP, PSEN1
2rough endoplasmic reticulumGO:00057919.9HCRT, PSEN1, PTGDS
3blood microparticleGO:00725629.5APOE, CLU, SERPINA3
4neuronal cell bodyGO:00430258.8APOE, PSEN1, SST, VIP
5perinuclear region of cytoplasmGO:00484718.3APP, CLU, HCRT, PSEN1, PTGDS
6Golgi apparatusGO:00057947.8APOE, APP, CLU, NPY, PSEN1, PTGDS
7extracellular spaceGO:00056156.7APOE, APP, CLU, NPY, PTGDS, PYY
8extracellular regionGO:00055765.7APOE, APP, CLU, HCRT, NPY, PTGDS

Biological processes related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1regulation of appetiteGO:003209810.3NPY, PYY
2negative regulation of potassium ion transportGO:004326710.2HCRT, VIP
3eating behaviorGO:004275510.1HCRT, PYY
4positive regulation of dendritic spine developmentGO:006099910.1APOE, PSEN1
5protein importGO:00170389.9APOE, CLU
6regulation of beta-amyloid clearanceGO:19002219.9APOE, CLU
7negative regulation of beta-amyloid formationGO:19024309.9APOE, CLU
8positive regulation of neurofibrillary tangle assemblyGO:19029989.9APOE, CLU
9positive regulation of beta-amyloid formationGO:19020049.9APOE, CLU
10positive regulation of neuron deathGO:19012169.8APOE, CLU
11regulation of epidermal growth factor-activated receptor activityGO:00071769.8APP, PSEN1
12reverse cholesterol transportGO:00436919.8APOE, CLU
13neuron apoptotic processGO:00514029.7APP, PSEN1
14feeding behaviorGO:00076319.7HCRT, NPY, PYY
15neuropeptide signaling pathwayGO:00072189.6HCRT, NPY, PYY
16response to yeastGO:00018789.5APP, NPY, VIP
17antifungal humoral responseGO:00197329.5APP, NPY, VIP
18defense response to Gram-negative bacteriumGO:00508299.5APP, NPY, VIP
19digestionGO:00075869.5NPY, PYY, SST
20regulation of neuron deathGO:19012149.3APOE, CLU
21lipid metabolic processGO:00066299.2APOE, CLU, PTGDS
22antibacterial humoral responseGO:00197319.0APP, NPY, VIP
23defense response to Gram-positive bacteriumGO:00508308.8APP, NPY, VIP

Molecular functions related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.3NPY, PYY, VIP
2hormone activityGO:00051798.8NPY, PYY, SST, VIP

Sources for Normal Pressure Hydrocephalus

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet