NPH
MCID: NRM002
MIFTS: 59

Normal Pressure Hydrocephalus (NPH) malady

Neuronal diseases category

Summaries for Normal Pressure Hydrocephalus

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43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NINDS:43 Normal pressure hydrocephalus (NPH) is an abnormal buildup of cerebrospinal fluid (CSF) in the brain's ventricles, or cavities. It occurs if the normal flow of CSF throughout the brain and spinal cord is blocked in some way. This causes the ventricles to enlarge, putting pressure on the brain. Normal pressure hydrocephalus can occur in people of any age, but it is most common in the elderly. It may result from a subarachnoid hemorrhage, head trauma, infection, tumor, or complications of surgery. However, many people develop NPH even when none of these factors are present. In these cases the cause of the disorder is unknown.

MalaCards: Normal Pressure Hydrocephalus, also known as hydrocephalus - normal pressure, is related to hydrocephalus and dementia. An important gene associated with Normal Pressure Hydrocephalus is VIP (vasoactive intestinal peptide), and among its related pathways are Glypican 1 network and NFAT and Cardiac Hypertrophy. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Wikipedia:63 Normal pressure hydrocephalus (NPH), also termed symptomatic hydrocephalus, is a type of brain... more...

Description from OMIM:46 236690

Aliases & Classifications for Normal Pressure Hydrocephalus

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8Disease Ontology, 43NINDS, 10DISEASES, 48Orphanet, 44Novoseek, 60UMLS, 56SNOMED-CT, 46OMIM, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
normal pressure hydrocephalus:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

normal pressure hydrocephalus 8 43 10 48
hydrocephalus - normal pressure 43
hydrocephalus, normal pressure 60
hydrocephalus normal pressure 44
chronic adult hydrocephalus 48
low pressure hydrocephalus 8
nph 48


External Ids:

Disease Ontology8 DOID:1572
OMIM46 236690
MeSH34 D006850
SNOMED-CT56 30753002, 69663004
ICD10 via Orphanet26 G91.2
SNOMED-CT via Orphanet57 30753002
ICD1025 G91.2

Related Diseases for Normal Pressure Hydrocephalus

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17GeneCards, 18GeneDecks
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Diseases related to Normal Pressure Hydrocephalus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1hydrocephalus32.2MAPT
2dementia31.1BDNF, GFAP, APP, APOE, GAL, PTGDS
3alzheimer's disease31.0NPY, GAL, GFAP, PTGDS, APOE, TGFBR2
4type 2 diabetes mellitus30.7PYY, GAL, APOE, ACE
5vascular disease30.5PTGDS, GFAP
6vascular dementia30.5APP, APOE, MAPT
7hypertension30.5APOE, NPY, ACE, TGFB1
8hyperglycemia30.5GAL, NPY, TGFB1, PYY, BDNF, ACE
9diabetes mellitus30.4PYY, APOE, ACE, TGFB1, NPY
10progressive supranuclear palsy30.4APOE, MAPT
11ischemia30.4GFAP, VIP, BDNF, GAL, MAPT
12huntington's disease30.4NPY, BDNF, APP, MAPT
13parkinson's disease30.3APP, APOE, GAL, MAPT, BDNF
14hypoglycemia30.3GAL, BDNF, NPY
15paraganglioma30.1GFAP, GAL
16obsessive-compulsive disorder30.1BDNF
17glaucoma30.1BDNF, NPY
18schizophrenia30.1PTGDS, BDNF, NPY
19arthritis30.1TGFB1, GAL, VIP
20rheumatoid arthritis30.1TGFBR2, VIP, BDNF
21frontotemporal dementia30.1APP, APOE, MAPT
22pick's disease30.1APP, APOE, MAPT
23cerebrovascular disease30.1APP, APOE, ACE
24multiple sclerosis30.1APOE, BDNF, TGFB1, NPY, GFAP, PTGDS
25hepatitis29.8GAL
26diabetic retinopathy29.8ACE
27cerebritis10.9
28type 1 diabetes mellitus10.5
29maturity-onset diabetes of the young, type 110.4
30arachnoiditis10.4
31intracranial hypertension10.4
32diabetic ketoacidosis10.3
33maturity-onset diabetes of the young10.3
34immunodysregulation, polyendocrinopathy and enteropathy x-linked10.3
35brittle diabetes10.3
36maturity-onset diabetes of the young, type 210.3
37maturity-onset diabetes of the young, type 610.3
38epiphyseal dysplasia multiple with early-onset diabetes mellitus10.3
39type 1 diabetes10.3
40diabetes, type 210.3
41rh-mod syndrome10.3
42syringomyelia10.3
43systemic lupus erythematosus10.3
44neuronitis10.3
45gait apraxia10.3
46apraxia10.3
47communicating hydrocephalus10.3
48lupus erythematosus10.3
49meningioma10.3
50peritonitis10.3

Graphical network of the top 20 diseases related to Normal Pressure Hydrocephalus:



Diseases related to normal pressure hydrocephalus

Clinical Features for Normal Pressure Hydrocephalus

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46OMIM
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Clinical features from OMIM:

236690

Drugs & Therapeutics for Normal Pressure Hydrocephalus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Normal Pressure Hydrocephalus

Drug clinical trials:

Search ClinicalTrials for Normal Pressure Hydrocephalus

Search NIH Clinical Center for Normal Pressure Hydrocephalus

Search CenterWatch for Normal Pressure Hydrocephalus

Genetic Tests for Normal Pressure Hydrocephalus

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Anatomical Context for Normal Pressure Hydrocephalus

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32MalaCards
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MalaCards organs/tissues related to Normal Pressure Hydrocephalus:

32
Brain, Spinal cord, Testes, Thalamus, Eye, Bone, Cortex, Olfactory bulb, Pituitary

Animal Models for Normal Pressure Hydrocephalus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Normal Pressure Hydrocephalus:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9TGFB1, APOE, NPY, ACE, PYY, TGFBR2
2MP:00053818.4TGFB1, TGFBR2, NPY, APOE, GFAP, BDNF
3MP:00107718.4PTGDS, BDNF, APP, APOE, GAL, MAPT
4MP:00028738.4GFAP, MAPT, APP, PYY, BDNF, VIP
5MP:00053898.3VIP, TGFB1, GAL, APOE, APP, BDNF
6MP:00053877.9MAPT, TGFB1, TGFBR2, PTGDS, ACE, GFAP
7MP:00053767.5TGFBR2, ACE, BDNF, TGFB1, GAL, NPY
8MP:00053787.4APP, MAPT, NPY, PYY, BDNF, GFAP
9MP:00107687.4APOE, MAPT, GFAP, ACE, PTGDS, TGFBR2
10MP:00053847.3APP, MAPT, TGFBR2, ACE, GFAP, SNPH
11MP:00036317.3PYY, APP, BDNF, APOE, NPY, GAL
12MP:00053866.5APP, NPY, PYY, BDNF, VIP, GAL

Publications for Normal Pressure Hydrocephalus

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50PubMed
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Articles related to Normal Pressure Hydrocephalus:

(show top 50)    (show all 519)
idTitleAuthorsYear
1
Normal pressure hydrocephalus mimicking Alzheimer's disease: such an infrequent case? (23863346)
2013
2
Patients benefit from low-pressure settings enabled by gravitational valves in normal pressure hydrocephalus. (23831048)
2013
3
Does the treatment of normal pressure hydrocephalus put the retinal ganglion cells at risk? A brief literature review and novel hypothesis. (23920271)
2013
4
Normal pressure hydrocephalus. (23930852)
2013
5
Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients. (23398333)
2013
6
Gait dysfunction in Parkinson's disease and normal pressure hydrocephalus: a comparative study. (23334795)
2013
7
How active are patients with idiopathic normal pressure hydrocephalus and does activity improve after shunt surgery? A controlled actigraphic study. (22673042)
2013
8
Assessment of a quick reference table algorithm for determining initial postoperative pressure settings of programmable pressure valves in patients with idiopathic normal pressure hydrocephalus: SINPHONI subanalysis. (22653392)
2012
9
Correlation between tap test and CSF aqueductal stroke volume in idiopathic normal pressure hydrocephalus. (22116421)
2012
10
Familial aggregation of idiopathic normal pressure hydrocephalus: novel familial case and a family study of the NPH triad in an iNPH patient cohort. (22921954)
2012
11
Guidelines for management of idiopathic normal pressure hydrocephalus: second edition. (23183074)
2012
12
Assessment of cerebral blood flow during infusion test in the diagnosis of normal pressure hydrocephalus. (23214300)
2012
13
In vivo viscoelastic properties of the brain in normal pressure hydrocephalus. (20931563)
2011
14
Role of computerized tomographic cisternography in idiopathic normal pressure hydrocephalus. (21611722)
2011
15
MR cisternography: is it useful in the diagnosis of normal-pressure hydrocephalus and the selection of "good shunt responders"? (20683818)
2011
16
Classification of morphological features extracted from intracranial pressure recordings in the diagnosis of Normal Pressure Hydrocephalus (NPH). (22254915)
2011
17
Normal pressure hydrocephalus after gamma knife radiosurgery for vestibular schwannoma. (20739769)
2010
18
Commentary: Huntington disease in a nonagenarian mistakenly diagnosed as normal pressure hydrocephalus. (20537542)
2010
19
Parkinsonian Symptomatology May Correlate with CT Findings before and after Shunting in Idiopathic Normal Pressure Hydrocephalus. (20948890)
2010
20
Differences in microstructural alterations of the hippocampus in Alzheimer disease and idiopathic normal pressure hydrocephalus: a diffusion tensor imaging study. (20671063)
2010
21
A case of normal-pressure hydrocephalus associated with rheumatoid arthritis. (20440105)
2010
22
The efficiency of PC-MRI in diagnosis of normal pressure hydrocephalus and prediction of shunt response. (19910214)
2010
23
Neuroradiological diagnosis of idiopathic normal-pressure hydrocephalus: the search for the Holy Grail. (19847909)
2009
24
Idiopathic normal pressure hydrocephalus: the benefits and problems of shunting. (19194387)
2009
25
Changes in aqueductal CSF stroke volume in shunted patients with idiopathic normal-pressure hydrocephalus. (19461060)
2009
26
Glaucomatous disease in patients with normal pressure hydrocephalus. (19295381)
2009
27
Heritable essential tremor-idiopathic normal pressure hydrocephalus (ETINPH). (18203159)
2008
28
Retrograde jugular flow associated with idiopathic normal pressure hydrocephalus. (18570299)
2008
29
Techniques and complications of external lumbar drainage for normal pressure hydrocephalus. (18981847)
2008
30
Predicting the outcome of shunt surgery in normal pressure hydrocephalus. (18640840)
2008
31
Elevated CNS concentrations of NFL in idiopathic normal pressure hydrocephalus (INPH) and subcortical arteriosclerotic encephalopathy (SAE). (18307570)
2008
32
Polyneuropathy complicating the diagnosis of normal pressure hydrocephalus: case report and review of literature. (17100034)
2006
33
First clinical experiences in patients with idiopathic normal-pressure hydrocephalus with the adjustable gravity valve manufactured by Aesculap (proGAV(Aesculap)). (16671487)
2006
34
When do common symptoms indicate normal pressure hydrocephalus? (16708712)
2006
35
Screening tests for normal-pressure hydrocephalus: sensitivity, specificity, and cost. (17405251)
2006
36
Intracranial compartment volumes in normal pressure hydrocephalus: volumetric assessment versus outcome. (16418361)
2006
37
The predictive value of external continuous lumbar drainage, with cerebrospinal fluid outflow controlled by medium pressure valve, in normal pressure hydrocephalus. (16041469)
2005
38
The prognostic value of clinical characteristics and parameters of cerebrospinal fluid hydrodynamics in shunting for idiopathic normal pressure hydrocephalus. (16047108)
2005
39
Alteration of cerebral perfusion in patients with idiopathic normal pressure hydrocephalus measured by 3D perfusion weighted magnetic resonance imaging. (16021357)
2005
40
Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients. (16028756)
2005
41
Association between cognitive impairment and gait disturbance in patients with idiopathic normal pressure hydrocephalus. (15908748)
2005
42
Pulse wave encephalopathy: a spectrum hypothesis incorporating Alzheimer's disease, vascular dementia and normal pressure hydrocephalus. (14962623)
2004
43
Immunoreactivities of amyloid beta peptide((1-42)) and total tau protein in lumbar cerebrospinal fluid of patients with normal pressure hydrocephalus. (14991454)
2004
44
Linear deposition of immunoglobulins and complement components on the dura in normal pressure hydrocephalus complicating systemic lupus erythematosus. (15177414)
2004
45
Is a combination of Tc-SPECT or perfusion weighted magnetic resonance imaging with spinal tap test helpful in the diagnosis of normal pressure hydrocephalus? (12640067)
2003
46
Acute subdural hematoma after lumboperitoneal shunt placement in patients with normal pressure hydrocephalus. (12760499)
2003
47
Postsurgical cerebral perfusion changes in idiopathic normal pressure hydrocephalus: a statistical parametric mapping study of SPECT images. (14660712)
2003
48
Comparison between the lumbar infusion and CSF tap tests to predict outcome after shunt surgery in suspected normal pressure hydrocephalus. (12438477)
2002
49
Normal pressure hydrocephalus in diabetic patients with recurrent episodes of hypoglycemic coma. (10670909)
2000
50
Neuropeptide Y cerebrospinal fluid levels in patients with normal pressure hydrocephalus syndrome. (8080906)
1994

Genetic Variations for Normal Pressure Hydrocephalus

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Expression for genes affiliated with Normal Pressure Hydrocephalus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Normal Pressure Hydrocephalus

Search GEO for disease gene expression data for Normal Pressure Hydrocephalus.

Pathways for genes affiliated with Normal Pressure Hydrocephalus

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 29KEGG, 52R&D Systems, 4Cell Signaling Technology
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Compounds for genes affiliated with Normal Pressure Hydrocephalus

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Normal Pressure Hydrocephalus according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7GFAP
2cycloheximide4410.2GAL, MAPT, PTGDS
3helospectin4410.1NPY, GAL, VIP
4secretoneurin4410.1VIP, GAL, NPY
5dsip4410.1PYY, NPY, GAL
6clonidine44 28 1112.0NPY, GAL, PYY
7trifluoroethanol44 1110.9MAPT, GAL, NPY, VIP
8thioflavine s449.8APP, APOE, MAPT
9atropine44 28 1111.8GAL, NPY, APP, PYY
10gnrh449.7GAL, VIP, PYY, BDNF, TGFBR2
11phosphoramidon44 1110.6VIP, APP, NPY, ACE
12tacrine44 1110.5MAPT, APOE, APP
13formate449.5APOE, APP, MAPT, GFAP
14donepezil44 11 2411.5MAPT, APP, APOE
156-hydroxydopamine449.4APP, VIP, GFAP, NPY, BDNF
16cocaine44 1110.4NPY, BDNF, PYY, GAL, GFAP
17streptozotocin449.4BDNF, NPY, GFAP, TGFB1, APOE
18capsaicin44 2810.4NPY, GAL, VIP, BDNF
19acth449.4PYY, BDNF, VIP, GAL, GFAP, NPY
20carbachol44 28 1111.3GAL, PYY, NPY, MAPT, VIP, APP
215-hydroxytryptamine449.3GFAP, NPY, PYY, APP, GAL, VIP
22octreotide44 59 28 1112.3VIP, PYY, NPY, GAL
23dopamine44 28 11 2412.2BDNF, PYY, APP, VIP, NPY, GFAP
24corticosterone44 59 2411.2GAL, GFAP, VIP, BDNF, APP, NPY
25nifedipine44 49 28 1112.2ACE, BDNF, TGFB1, NPY, VIP
26isoproterenol44 1110.2APP, VIP, PYY, GFAP, MAPT, NPY
27verapamil44 49 28 11 2413.2GFAP, TGFB1, VIP, APP, ACE
28nmda44 2810.1APP, APOE, MAPT, GFAP, BDNF
29tetrodotoxin44 59 2811.1GAL, VIP, BDNF, PYY, APOE, NPY
30kainate44 2810.1TGFB1, GFAP, MAPT, NPY, APOE, BDNF
31glucose449.1TGFBR2, GFAP, NPY, MAPT, GAL, PYY
32formaldehyde44 2410.1GFAP, NPY, APP, GAL, MAPT, TGFB1
33histamine44 28 2411.1PTGDS, TGFB1, GAL, NPY, BDNF, PYY
34nicotine44 49 28 1112.0APP, APOE, NPY, MAPT, TGFB1
35gaba449.0GFAP, VIP, BDNF, PYY, APP, GAL
36valine449.0VIP, MAPT, APOE, BDNF, APP
37norepinephrine44 11 2410.9VIP, PYY, BDNF, APP, NPY, GAL
38serine448.8PYY, TGFB1, GFAP, MAPT, GAL, APP
39adenylate448.8APP, NPY, GAL, VIP, GFAP, TGFBR2
40acetylcholine44 49 28 11 2412.8GAL, ACE, GFAP, MAPT, APP, BDNF
41actinomycin d448.8BDNF, APOE, APP, TGFB1, MAPT, TGFBR2
42arginine448.7NPY, GFAP, MAPT, GAL, APOE, APP
43choline44 11 2410.6VIP, BDNF, NPY, TGFB1, GFAP, GAL
44glutamine448.6APOE, VIP, APP, NPY, MAPT, TGFBR2
45cholesterol44 28 11 2411.5PTGDS, TGFBR2, ACE, GFAP, APOE, APP
46testosterone44 59 11 2411.4GAL, NPY, APOE, BDNF, VIP, APP
47glutamate448.4VIP, APOE, BDNF, NPY, GAL, MAPT
48alanine448.4VIP, APP, MAPT, APOE, NPY, GAL
49retinoic acid44 249.3TGFB1, TGFBR2, PTGDS, GFAP, MAPT, NPY
50creatinine448.2PTGDS, BDNF, APP, APOE, NPY, TGFB1

GO Terms for genes affiliated with Normal Pressure Hydrocephalus

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16Gene Ontology
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Cellular components related to Normal Pressure Hydrocephalus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.1TGFB1, SNPH, APOE, VIP
2extracellular spaceGO:0056158.0PYY, APOE, NPY, LRG1, ACE, PTGDS
3extracellular regionGO:0055767.1TGFB1, VIP, BDNF, PYY, APP, APOE

Biological processes related to Normal Pressure Hydrocephalus according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1common-partner SMAD protein phosphorylationGO:00718210.1TGFB1, TGFBR2
2response to cholesterolGO:07072310.0TGFB1, TGFBR2
3mononuclear cell proliferationGO:03294310.0ACE, TGFB1
4negative regulation of neuroblast proliferationGO:0074069.9TGFB1, BDNF
5myeloid dendritic cell differentiationGO:0430119.9TGFB1, TGFBR2
6axon cargo transportGO:0080889.9MAPT, APP
7negative regulation of blood vessel endothelial cell migrationGO:0435379.7TGFB1, APOE
8feeding behaviorGO:0076319.7PYY, NPY, GAL, BDNF
9agingGO:0075689.6APOE, TGFB1, TGFBR2
10pathway-restricted SMAD protein phosphorylationGO:0603899.6TGFB1, TGFBR2

Molecular functions related to Normal Pressure Hydrocephalus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.9MAPT, APOE
2neuropeptide hormone activityGO:0051849.3GAL, NPY, PYY, VIP

Products for genes affiliated with Normal Pressure Hydrocephalus

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Normal Pressure Hydrocephalus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet