MCID: NRM002
MIFTS: 50

Normal Pressure Hydrocephalus malady

Categories: Neuronal diseases, Rare diseases, Blood diseases

Aliases & Classifications for Normal Pressure Hydrocephalus

About this section
Sources:
11Disease Ontology, 13DISEASES, 29ICD10, 30ICD10 via Orphanet, 38MeSH, 48NINDS, 49Novoseek, 53Orphanet, 61SNOMED-CT, 63The Human Phenotype Ontology, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Normal Pressure Hydrocephalus:

Name: Normal Pressure Hydrocephalus 11 48 53 13
Hydrocephalus, Normal Pressure 38 67
Hydrocephalus - Normal Pressure 48
Hydrocephalus Normal Pressure 49
 
Chronic Adult Hydrocephalus 53
Low Pressure Hydrocephalus 11
Nph 53

Characteristics:

Orphanet epidemiological data:

53
normal pressure hydrocephalus:
Inheritance: Not applicable; Age of onset: Adult


Classifications:



External Ids:

Disease Ontology11 DOID:1572
ICD1029 G91.2
MeSH38 D006850
SNOMED-CT61 30753002, 69663004
Orphanet53 ORPHA314928
UMLS via Orphanet68 C0020258
ICD10 via Orphanet30 G91.2

Summaries for Normal Pressure Hydrocephalus

About this section
NINDS:48 Normal pressure hydrocephalus (NPH) is an abnormal buildup of cerebrospinal fluid (CSF) in the brain's ventricles, or cavities. It occurs if the normal flow of CSF throughout the brain and spinal cord is blocked in some way. This causes the ventricles to enlarge, putting pressure on the brain. Normal pressure hydrocephalus can occur in people of any age, but it is most common in the elderly. It may result from a subarachnoid hemorrhage, head trauma, infection, tumor, or complications of surgery. However, many people develop NPH even when none of these factors are present. In these cases the cause of the disorder is unknown.

MalaCards based summary: Normal Pressure Hydrocephalus, also known as hydrocephalus, normal pressure, is related to nephronophthisis and hydrocephalus, and has symptoms including urinary incontinence, dementia and global developmental delay. An important gene associated with Normal Pressure Hydrocephalus is PMPCA (Peptidase, Mitochondrial Processing Alpha Subunit), and among its related pathways are A-beta Pathways: Uptake and Degradation and A-beta Pathways: Plaque Formation and APP Metabolism. Affiliated tissues include brain, testes and spinal cord, and related mouse phenotypes are muscle and respiratory system.

Wikipedia:70 Normal pressure hydrocephalus (NPH), also termed symptomatic hydrocephalus, is a type of brain... more...

Related Diseases for Normal Pressure Hydrocephalus

About this section

Diseases related to Normal Pressure Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1nephronophthisis11.3
2hydrocephalus11.0
3glomerulosclerosis, focal segmental, 210.9
4nephronophthisis 410.8
5nephronophthisis 1, juvenile10.8
6nephronophthisis 310.8
7nephrotic syndrome, type 110.7
8glomerulosclerosis, focal segmental, 410.7
9glomerulosclerosis, focal segmental, 310.7
10glomerulosclerosis, focal segmental, 510.7
11glomerulosclerosis, focal segmental, 110.7
12cerebritis10.4
13dementia10.3
14limited scleroderma10.2PTGDS, SERPINA3
15retinal arteries, tortuosity of10.2APOE, APP
16samson viljoen syndrome10.2APOE, PSEN1
17congenital hypoplastic anemia10.1APOE, PSEN1
18enteropathy-associated t-cell lymphoma10.1APP, PSEN1
19testicular seminoma10.1APOE, PSEN1
20atrial septal defect 910.1APP, HCRT
21amyloidosis bronchopulmonary10.1TTR, VIP
22alzheimer disease10.0
23cerebral atrophy10.0
24encephalopathy10.0
25allergic bronchopulmonary aspergillosis, familial10.0APOE, APP, SERPINA3
26bile duct cystadenoma9.9HCRT, PSEN1
27arachnoiditis9.9
28lethal congenital contracture syndrome 19.9APOE, TTR
29intravascular angioleiomyoma9.9APOE, APP, PSEN1
30epidermolysis bullosa with pyloric atresia9.9APOE, APP, PSEN1
31constrictive pericarditis9.9NPY, TTR
32nosophobia9.9APOE, PSEN1
33syringomyelia9.9
34vascular dementia9.9
35intracranial hypertension9.9
36arachnoid cysts9.9
37subcortical arteriosclerotic encephalopathy9.9
38pick disease9.9APOE, APP, PSEN1
39vaginal tubular adenoma9.8APOE, APP, PSEN1
40meier-gorlin syndrome 59.8APOE, APP
41angiomyolipoma9.8APOE, APP, PSEN1
42avoidant personality disorder9.8APOE, HCRT, PSEN1
43gemistocytic astrocytoma9.8APOE, APP, PSEN1
44schizophrenia9.8
45systemic lupus erythematosus9.8
46huntington disease9.8
47apraxia9.8
48choroiditis9.8
49polyneuropathy9.8
50communicating hydrocephalus9.8

Graphical network of the top 20 diseases related to Normal Pressure Hydrocephalus:



Diseases related to normal pressure hydrocephalus

Symptoms for Normal Pressure Hydrocephalus

About this section

Human phenotypes related to Normal Pressure Hydrocephalus:

 63 (show all 6)
id Description HPO Frequency HPO Source Accession
1 urinary incontinence63 HP:0000020
2 dementia63 HP:0000726
3 global developmental delay63 HP:0001263
4 gait disturbance63 HP:0001288
5 normal pressure hydrocephalus63 HP:0002343
6 bowel incontinence63 HP:0002607

Drugs & Therapeutics for Normal Pressure Hydrocephalus

About this section

Drugs for Normal Pressure Hydrocephalus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
CitalopramapprovedPhase 450359729-33-82771
Synonyms:
1,3-Dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile
1,3-dihydro[3,4]benzofuran-5-carbonitrile
1-(3-(Dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile
59729-33-8
AB00513896
AC-12214
AC1L1EFH
AE-641/00603021
Akarin
BPBio1_000929
BRD-A47598013-004-02-0
BSPBio_000843
Bonitrile
C07572
C20H21FN2O
CHEBI:3723
CHEMBL549
CID2771
CPD000465669
Celapram
Celexa
Celius
Ciazil
Cilift
Cipram
Cipramil
Ciprapine
Citabax
Citadur
Citadur (TN)
Citalec
Citalopram (USP/INN)
Citalopram Hydrobromide
Citalopram [Celexa]
Citalopram [INN:BAN]
Citalopram hydrobromide
Citalopramum
Citalopramum [INN-Latin]
 
Citol
Citopam
Citox
Citrol
Cytalopram
D07704
DB00215
Dalsan
EINECS 261-891-1
Elopram
HMS2090O09
HMS2093A14
Humorup
I01-0382
InChI=1/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3
L001223
LS-84327
Lopac0_000258
Lu 10-171
Lu-10-171
MolPort-003-666-794
NCGC00015267-07
NCGC00025160-02
Nitalapram
Oropram
Pramcit
Prestwick3_000692
Recital
SAM002589960
ST069372
STL058639
Seropram
Talam
Talohexal
Temperax
UNII-0DHU5B8D6V
Vodelax
Zentius
Zetalo
[3H]Citalopram
citalopram
2
SerotoninPhase 4356650-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
3Serotonin AgentsPhase 43102
4Neurotransmitter Uptake InhibitorsPhase 43464
5Cholinergic AgentsPhase 43846
6Serotonin Uptake InhibitorsPhase 41570
7Cholinergic AntagonistsPhase 41658
8Muscarinic AntagonistsPhase 41134
9Neurotransmitter AgentsPhase 417734
10
Acetazolamideapproved, vet_approvedPhase 37559-66-51986
Synonyms:
1424-27-7 (mono-hydrochloride salt)
1yda
1ydb
1ydd
1zsb
2-acetylamino-1,3,4-Thiadiazole-5-sulfonamide
2h4n
3czv
4-Diamox
5-ACETAMIDO-1,3,4-thiadiazole-2-sulfonamide
5-acetylamino-1,3,4-Thiadiazole-2-sulfonamide
5661-25-6
59-66-5
8017-69-4
A 6011
A6011_SIAL
A6011_SIGMA
AB00051906
AC-12779
AC1L1CO5
AI3-52458
AKOS000715163
Acetadiazol
Acetamidothiadiazolesulfonamide
Acetamox
Acetazolam
Acetazolamid
Acetazolamida
Acetazolamida [INN-Spanish]
Acetazolamide (AAZ)
Acetazolamide (JP15/USP/INN)
Acetazolamide Apotex Brand
Acetazolamide Chiesi Brand
Acetazolamide Dioptic Brand
Acetazolamide Grin Brand
Acetazolamide ICN Brand
Acetazolamide Jumer Brand
Acetazolamide Llorens Brand
Acetazolamide Medphano Brand
Acetazolamide Novopharm Brand
Acetazolamide Orion Brand
Acetazolamide Sodium
Acetazolamide Sodium, (Sterile)
Acetazolamide Wassermann Brand
Acetazolamide [INN:BAN:JAN]
Acetazolamide, Monosodium Salt
Acetazolamidum
Acetazolamidum [INN-Latin]
Acetazolamine
Acetazoleamide
Acetozalamide
Acétazolamide
Ak Zol
Ak-Zol
AkZol
Apo Acetazolamide
Apo-Acetazolamide
ApoAcetazolamide
Apotex Brand of Acetazolamide
Atenezol
BAS 01585728
BIDD:GT0643
BPBio1_000007
BSPBio_000005
BSPBio_001788
C06805
C4H6N4O3S2
CAS-59-66-5
CCRIS 5811
CHEBI:27690
CHEMBL20
CID1986
CPD0-1626
CPD000058394
Carbonic Anhydrase Inhibitor 6063
Carbonic Anhydrase Inhibitor No. 6063
Carbonic anhydrase inhibitor 6063
Chiesi Brand of Acetazolamide
Ciba Vision Brand of Acetazolamide
Cidamex
D000086
D00218
DB00819
Dazamide
Defiltran
Dehydratin
Diacarb
Diakarb
Diamox
Diamox (TN)
Diamox Sequels
Didoc
Diluran
 
Dioptic Brand of Acetazolamide
Diuramid
Diuramide
Diureticum-Holzinger
Diureticum-holzinger
Diuriwas
Diutazol
DivK1c_000017
Donmox
Duiramid
EINECS 200-440-5
EU-0100039
Edemox
Eumicton
Fonurit
Glauconox
Glaumox
Glaupax
Glupax
Grin Brand of Acetazolamide
HMS1568A07
HMS1920A05
HMS2091G05
HMS500A19
HSDB 3002
Huma Zolamide
Huma-Zolamide
HumaZolamide
I09-0425
ICN Brand of Acetazolamide
IDI1_000017
Jumer Brand of Acetazolamide
KBio1_000017
KBio2_000358
KBio2_002926
KBio2_005494
KBio3_001288
KBioGR_000558
KBioSS_000358
LS-10227
Llorens Brand of Acetazolamide
Lopac-A-6011
Lopac0_000039
MLS000028435
MLS001148438
Medphano Brand of Acetazolamide
MolPort-001-783-578
Monosodium Salt Acetazolamide
N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
N-[5-(Aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide
NCGC00015074-01
NCGC00015074-02
NCGC00015074-03
NCGC00015074-06
NCGC00015074-11
NCGC00023455-03
NCGC00023455-04
NCGC00023455-05
NCGC00023455-06
NCGC00023455-07
NINDS_000017
NSC 145177
NSC145177
Natrionex
Nephramid
Nephramide
Novopharm Brand of Acetazolamide
Orion Brand of Acetazolamide
Phonurit
Prestwick0_000003
Prestwick1_000003
Prestwick2_000003
Prestwick3_000003
Prestwick_4
SAM002554883
SBB056640
SK-acetazolamide
SMR000058394
SPBio_000004
SPBio_001926
SPECTRUM1500102
Sk-Acetazolamide
Spectrum2_000082
Spectrum3_000284
Spectrum4_000139
Spectrum5_000738
Spectrum_000018
Storz Brand of Acetazolamide Preparation
Storzolamide
UNII-O3FX965V0I
Vetamox
WLN: T5NN DSJ CSZW EMV1
Wassermann Brand of Acetazolamide
Wyeth Brand of Acetazolamide Preparation
acetazolamide
11Pharmaceutical SolutionsPhase 2, Phase 37793
12Anti-Infective Agents, LocalPhase 2, Phase 31785
13AnestheticsPhase 2, Phase 39001
14diureticsPhase 31372
15Natriuretic AgentsPhase 31645
16Carbonic Anhydrase InhibitorsPhase 3179
17AnticonvulsantsPhase 32620
18Mitogens1526

Interventional clinical trials:

(show all 40)
idNameStatusNCT IDPhase
1Normal Pressure Hydrocephalus (NPH) RegistryCompletedNCT00233701Phase 4
2Efficacy and Safety of Selective Serotonin Reuptake Inhibitor (SSRI) in Overactive Bladder PatientsCompletedNCT00902421Phase 4
3ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH PatientsCompletedNCT01323764Phase 4
4ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) PatientsWithdrawnNCT00793416Phase 4
5Clinical Value of Noninvasive Intracranial Pressure MeasurementUnknown statusNCT02130219Phase 2, Phase 3
6PET Imaging of Brain Amyloid in Normal Pressure HydrocephalusCompletedNCT01053312Phase 3
7A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System.CompletedNCT00196196Phase 3
8Normal Pressure Hydrocephalus Treatment by AcetazolamideRecruitingNCT02163330Phase 3
9Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure HydrocephalusTerminatedNCT01092546Phase 3
10ETV Versus Shunt Surgery in Normal Pressure HydrocephalusTerminatedNCT00946127Phase 3
11Study to Evaluate Efficacy of Shunt Operation for Idiopathic Normal Pressure HydrocephalusCompletedNCT00221091Phase 2
12Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure HydrocephalusUnknown statusNCT00600795
13Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure HydrocephalusUnknown statusNCT01618500
14European Study on Prediction of Outcome in Patients With Idiopathic Normal Pressure HydrocephalusUnknown statusNCT00874198
15Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral IschemiaUnknown statusNCT00494689
16Magnetic Resonance Elastography in HydrocephalusUnknown statusNCT02230124
17Cerebral Blood Circulation in Patients With Posterior Fossa Brain TumorUnknown statusNCT01476670
18A Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure HydrocephalusCompletedNCT01570257
19Predictive Value of Flow MRI in Normal Pressure Hydrocephalus SurgeryCompletedNCT01815775Early Phase 1
20Computerized Neuropsychology in Idiopathic Normal Pressure Hydrocephalus (INPH)CompletedNCT01265251
21A Study Comparing Shunt Placement Versus Endoscopic Third Ventriculostomy in the Treatment of HydrocephalusCompletedNCT01115270
22Vascular Risk Factors in INPH-patientsCompletedNCT01850914
23Cerebrospinal Fluid Proteome in HydrocephalusCompletedNCT02016352
24Improved Analysis Methods for Infusion TestsCompletedNCT01319136
25Intracranial Pressure Waves Via Lumbar PunctureCompletedNCT01374048
26Value of Radionuclide CisternographyCompletedNCT02876614
27Comparison of Continuous Noninvasive and Invasive Intracranial Pressure Measurement--Celda Infusion SubprotocolCompletedNCT01976559
28Reference Values of Cerebrospinal Fluid Outflow Resistance and Intracranial Pressure in Healthy ElderlyCompletedNCT01188382
29Establishing the Physiology of SyringomyeliaCompletedNCT00001327
30Flow MRI in Normal Pressure HydrocephalusRecruitingNCT01909960
31Effects of Physical Training in iNPHRecruitingNCT02659111
32A Randomized Cross-over Study for Normal Pressure HydrocephalusRecruitingNCT01798641
33Novel Parameters for the Prediction of Ventriculoperitoneal Shunting Efficacy in Patients With iNPHRecruitingNCT02495610
34Prognostic Value of Aβ Imaging in NPH Prior to Shunt PlacementRecruitingNCT01834625Early Phase 1
35Noninvasive Intracranial Pressure and Hydrocephalus PatientsEnrolling by invitationNCT02404740
36An Evaluation of Non-Invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an Intraparenchymal Pressure Monitoring DeviceSuspendedNCT02773888
37Factors Predicting Response to Shunting in Normal Pressure HydrocephalusTerminatedNCT00613886
38Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus (INPH)TerminatedNCT00727142
39Anterior Pituitary Function in Patients With HydrocephalusTerminatedNCT00149721
40Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in LifeWithdrawnNCT01377805

Search NIH Clinical Center for Normal Pressure Hydrocephalus


Cochrane evidence based reviews: hydrocephalus, normal pressure

Genetic Tests for Normal Pressure Hydrocephalus

About this section

Anatomical Context for Normal Pressure Hydrocephalus

About this section

MalaCards organs/tissues related to Normal Pressure Hydrocephalus:

35
Brain, Testes, Spinal cord, Pituitary, Thalamus, Olfactory bulb, Bone

Animal Models for Normal Pressure Hydrocephalus or affiliated genes

About this section

MGI Mouse Phenotypes related to Normal Pressure Hydrocephalus:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5ADORA2A, APOE, APP, HCRT, PSEN1
2MP:00053887.9ADORA2A, APOE, HCRT, PSEN1, VIP
3MP:00053867.5ADORA2A, APOE, APP, HCRT, NPY, PSEN1
4MP:00053766.9ADORA2A, APOE, APP, HCRT, NPY, PSEN1

Publications for Normal Pressure Hydrocephalus

About this section

Articles related to Normal Pressure Hydrocephalus:

(show top 50)    (show all 626)
idTitleAuthorsYear
1
Decreased Expression of hsa-miR-4274 inA Cerebrospinal Fluid of Normal Pressure Hydrocephalus Mimics with Parkinsonian Syndromes. (27911315)
2017
2
Timing of surgical treatment for idiopathic normal pressure hydrocephalus: association between treatment delay and reduced short-term benefit. (27581314)
2016
3
Normal pressure hydrocephalus and parkinsonism: preliminary data on neurosurgical and neurological treatment. (26970480)
2016
4
Optimized surgical treatment for normal pressure hydrocephalus: comparison between gravitational and differential pressure valves. (25666108)
2015
5
Symptoms of Depression Are Common in Patients With Idiopathic Normal Pressure Hydrocephalus. (26528670)
2015
6
Dynamic state of water molecular displacement of the brain during the cardiac cycle in idiopathic normal pressure hydrocephalus. (25614094)
2015
7
Pulse wave myelopathy: An update of an hypothesis highlighting the similarities between syringomyelia and normal pressure hydrocephalus. (26362731)
2015
8
Aspirin is associated with an increased risk of subdural hematoma in normal-pressure hydrocephalus patients following shunt implantation. (25555087)
2015
9
DTI-MRI biomarkers in the search for normal pressure hydrocephalus aetiology: a review. (25345377)
2014
10
CSF dynamic analysis of a predictive pulsatility-based infusion test for normal pressure hydrocephalus. (24151060)
2014
11
Idiopathic normal pressure hydrocephalus: cerebral perfusion measured with pCASL before and repeatedly after CSF removal. (25138210)
2014
12
Journal club: role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial. (24141398)
2013
13
Normal pressure hydrocephalus in the spectrum of neurological complications of systemic lupus erythematosus. (22829132)
2013
14
Design and benchmark testing of a bicorporal pump for the treatment of normal-pressure hydrocephalus and idiopathic intracranial hypertension. (23215632)
2013
15
Natural course of idiopathic normal pressure hydrocephalus. (24292998)
2013
16
Patients benefit from low-pressure settings enabled by gravitational valves in normal pressure hydrocephalus. (23831048)
2013
17
Assessment of a quick reference table algorithm for determining initial postoperative pressure settings of programmable pressure valves in patients with idiopathic normal pressure hydrocephalus: SINPHONI subanalysis. (22653392)
2012
18
The CSF tap test in normal pressure hydrocephalus: evaluation time, reliability and the influence of pain. (21801282)
2012
19
Lumboperitoneal shunts for the treatment of normal pressure hydrocephalus. (22705135)
2012
20
Normal pressure hydrocephalus as an unusual presentation of supratentorial extraventricular space-occupying processes: report on two cases. (22666203)
2012
21
Is the midbrain involved in the manifestation of gait disturbance in idiopathic normal-pressure hydrocephalus? (21132323)
2011
22
Potential placebo effect in assessing idiopathic normal pressure hydrocephalus. (21250799)
2011
23
Familial normal pressure hydrocephalus (NPH) with an autosomal-dominant inheritance: a novel subgroup of NPH. (21704338)
2011
24
Impact of duration of symptoms on CSF dynamics in idiopathic normal pressure hydrocephalus. (20849400)
2011
25
Normal-pressure hydrocephalus and cerebral blood flow. (20367076)
2010
26
Brain drain: A bottom-up approach to normal pressure hydrocephalus. (20976762)
2010
27
CSF neurotransmitter metabolites and neuropsychiatric symptomatology in patients with normal pressure hydrocephalus. (19046799)
2009
28
Normal pressure hydrocephalus after radiosurgery for sphenoid ridge meningioma. (19013812)
2009
29
Cerebrospinal fluid drainage and dynamics in the diagnosis of normal pressure hydrocephalus. (19404152)
2009
30
Idiopathic normal pressure hydrocephalus: thoughts on etiology and pathophysiology. (19640656)
2009
31
Idiopathic normal pressure hydrocephalus: increased supplementary motor activity accounts for improvement after CSF drainage. (18931387)
2008
32
Idiopathic normal pressure hydrocephalus: new findings and thoughts on etiology. (18192342)
2008
33
Changes in intracranial pulse pressure amplitudes after shunt implantation and adjustment of shunt valve opening pressure in normal pressure hydrocephalus. (18936877)
2008
34
Recognition of gait disturbances in patients with normal pressure hydrocephalus using a computer dynography system. (19218644)
2008
35
Features of gait most responsive to tap test in normal pressure hydrocephalus. (18359152)
2008
36
Gait disturbance in normal pressure hydrocephalus: a clinical study. (17052947)
2007
37
Noninvasive MRI assessment of intracranial compliance in idiopathic normal pressure hydrocephalus. (17610284)
2007
38
In vivo presynaptic and postsynaptic striatal dopamine functions in idiopathic normal pressure hydrocephalus. (16926840)
2007
39
Evaluation and treatment of patients with suspected normal pressure hydrocephalus on long-term warfarin anticoagulation therapy. (17327794)
2007
40
Is it possible to optimize treatment of patients with idiopathic normal pressure hydrocephalus by implanting an adjustable Medos Hakim valve in combination with a Miethke shunt assistant? (16671490)
2006
41
Clinical outcome of patients with idiopathic normal pressure hydrocephalus three years after shunt implantation. (16671489)
2006
42
Broadening a classic clinical triad: The hypokinetic motor disorder of normal pressure hydrocephalus also affects the hand. (16375891)
2006
43
When do common symptoms indicate normal pressure hydrocephalus? (16708712)
2006
44
The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus. (16160426)
2005
45
The predictive value of external continuous lumbar drainage, with cerebrospinal fluid outflow controlled by medium pressure valve, in normal pressure hydrocephalus. (16041469)
2005
46
Pulse wave encephalopathy: a spectrum hypothesis incorporating Alzheimer's disease, vascular dementia and normal pressure hydrocephalus. (14962623)
2004
47
Normal pressure hydrocephalus: what it is and how it is treated. (15456117)
2004
48
Unifying concept for Alzheimer's disease, vascular dementia and normal pressure hydrocephalus - a hypothesis. (15488655)
2004
49
Idiopathic normal pressure hydrocephalus predominantly with prolonged fever and hyponatremia. (12939438)
2003
50
Cerebral hemodynamics before and after shunting in normal pressure hydrocephalus. (12174170)
2002

Variations for Normal Pressure Hydrocephalus

About this section

Clinvar genetic disease variations for Normal Pressure Hydrocephalus:

5
id Gene Variation Type Significance SNP ID Assembly Location
1PMPCANM_015160.2(PMPCA): c.1129G> A (p.Ala377Thr)SNVPathogenicrs753611141GRCh38Chr 9, 136418847: 136418847
2PMPCANM_015160.2(PMPCA): c.1066G> A (p.Gly356Ser)SNVPathogenicrs768643552GRCh37Chr 9, 139313082: 139313082

Expression for genes affiliated with Normal Pressure Hydrocephalus

About this section
Search GEO for disease gene expression data for Normal Pressure Hydrocephalus.

Pathways for genes affiliated with Normal Pressure Hydrocephalus

About this section

Pathways related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6APOE, APP
29.1APP, PSEN1
38.8APOE, APP, PSEN1
48.4APOE, APP, NPY, PSEN1

GO Terms for genes affiliated with Normal Pressure Hydrocephalus

About this section

Cellular components related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ciliary rootletGO:00352539.8APP, PSEN1
2smooth endoplasmic reticulumGO:00057909.5APP, PSEN1
3dendritic shaftGO:00431989.5APP, PSEN1
4rough endoplasmic reticulumGO:00057919.1APP, HCRT, PSEN1, PTGDS
5Golgi apparatusGO:00057948.2APOE, APP, NPY, PSEN1, PTGDS
6neuronal cell bodyGO:00430258.1ADORA2A, APOE, PSEN1, VIP
7extracellular spaceGO:00056157.7APOE, APP, NPY, PMPCA, PTGDS, SERPINA3
8extracellular regionGO:00055766.9APOE, APP, HCRT, NPY, PTGDS, SERPINA3

Biological processes related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of potassium ion transportGO:004326710.2HCRT, VIP
2synaptic transmission, cholinergicGO:00072719.9ADORA2A, APOE
3eating behaviorGO:00427559.9ADORA2A, HCRT
4smooth endoplasmic reticulum calcium ion homeostasisGO:00515639.7APP, PSEN1
5protein kinase C-activating G-protein coupled receptor signaling pathwayGO:00072059.7ADORA2A, HCRT
6excitatory postsynaptic potentialGO:00600799.7ADORA2A, HCRT
7regulation of epidermal growth factor-activated receptor activityGO:00071769.7APP, PSEN1
8positive regulation of dendritic spine developmentGO:00609999.7APOE, PSEN1
9blood circulationGO:00080159.6ADORA2A, NPY
10regulation of protein bindingGO:00433939.5APP, PSEN1
11regulation of synaptic plasticityGO:00481679.5ADORA2A, PSEN1
12positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:00105799.3ADORA2A, VIP
13neuron apoptotic processGO:00514029.3APP, PSEN1
14learning or memoryGO:00076119.2PSEN1, VIP
15vasodilationGO:00423119.2ADORA2A, APOE
16response to oxidative stressGO:00069799.1APOE, APP, PSEN1
17negative regulation of neuron apoptotic processGO:00435248.7ADORA2A, APOE, PSEN1
18cellular protein metabolic processGO:00442678.2ADORA2A, APP, PSEN1, TTR

Molecular functions related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.8HCRT, NPY, VIP
2identical protein bindingGO:00428028.4ADORA2A, APOE, APP, TTR

Sources for Normal Pressure Hydrocephalus

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet