NPH
MCID: NRM002
MIFTS: 59

Normal Pressure Hydrocephalus (NPH) malady

Neuronal diseases category

Summaries for Normal Pressure Hydrocephalus

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43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NINDS:43 Normal pressure hydrocephalus (NPH) is an abnormal buildup of cerebrospinal fluid (CSF) in the brain's ventricles, or cavities. It occurs if the normal flow of CSF throughout the brain and spinal cord is blocked in some way. This causes the ventricles to enlarge, putting pressure on the brain. Normal pressure hydrocephalus can occur in people of any age, but it is most common in the elderly. It may result from a subarachnoid hemorrhage, head trauma, infection, tumor, or complications of surgery. However, many people develop NPH even when none of these factors are present. In these cases the cause of the disorder is unknown.

MalaCards: Normal Pressure Hydrocephalus, also known as hydrocephalus - normal pressure, is related to hydrocephalus and dementia. An important gene associated with Normal Pressure Hydrocephalus is VIP (vasoactive intestinal peptide), and among its related pathways are Glypican 1 network and Toll-like receptor signaling pathway. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Wikipedia:63 Normal pressure hydrocephalus (NPH), also termed symptomatic hydrocephalus, is a type of brain... more...

Description from OMIM:46 236690

Aliases & Classifications for Normal Pressure Hydrocephalus

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8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 46OMIM, 34MeSH, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
normal pressure hydrocephalus:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

normal pressure hydrocephalus 8 43 10 48
hydrocephalus - normal pressure 43
hydrocephalus, normal pressure 60
hydrocephalus normal pressure 44
chronic adult hydrocephalus 48
low pressure hydrocephalus 8
nph 48


External Ids:

Disease Ontology8 DOID:1572
OMIM46 236690
MeSH34 D006850
SNOMED-CT56 30753002, 69663004
ICD10 via Orphanet26 G91.2
SNOMED-CT via Orphanet57 30753002
ICD1025 G91.2

Related Diseases for Normal Pressure Hydrocephalus

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Normal Pressure Hydrocephalus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1hydrocephalus32.2MAPT
2dementia31.1BDNF, GFAP, APP, APOE, GAL, PTGDS
3alzheimer's disease31.0NPY, GAL, GFAP, PTGDS, APOE, TGFBR2
4type 2 diabetes mellitus30.7PYY, GAL, APOE, ACE
5vascular disease30.5PTGDS, GFAP
6vascular dementia30.5APP, APOE, MAPT
7hypertension30.5APOE, NPY, ACE, TGFB1
8hyperglycemia30.5GAL, NPY, TGFB1, PYY, BDNF, ACE
9diabetes mellitus30.4PYY, APOE, ACE, TGFB1, NPY
10progressive supranuclear palsy30.4APOE, MAPT
11ischemia30.4GFAP, VIP, BDNF, GAL, MAPT
12huntington's disease30.4NPY, BDNF, APP, MAPT
13parkinson's disease30.3APP, APOE, GAL, MAPT, BDNF
14hypoglycemia30.3GAL, BDNF, NPY
15paraganglioma30.1GFAP, GAL
16obsessive-compulsive disorder30.1BDNF
17glaucoma30.1BDNF, NPY
18schizophrenia30.1PTGDS, BDNF, NPY
19arthritis30.1TGFB1, GAL, VIP
20rheumatoid arthritis30.1TGFBR2, VIP, BDNF
21frontotemporal dementia30.1APP, APOE, MAPT
22pick's disease30.1APP, APOE, MAPT
23cerebrovascular disease30.1APP, APOE, ACE
24multiple sclerosis30.1APOE, BDNF, TGFB1, NPY, GFAP, PTGDS
25hepatitis29.8GAL
26diabetic retinopathy29.8ACE
27cerebritis10.9
28type 1 diabetes mellitus10.5
29maturity-onset diabetes of the young, type 110.4
30arachnoiditis10.4
31intracranial hypertension10.4
32diabetic ketoacidosis10.3
33maturity-onset diabetes of the young10.3
34immunodysregulation, polyendocrinopathy and enteropathy x-linked10.3
35brittle diabetes10.3
36maturity-onset diabetes of the young, type 210.3
37maturity-onset diabetes of the young, type 610.3
38epiphyseal dysplasia multiple with early-onset diabetes mellitus10.3
39type 1 diabetes10.3
40diabetes, type 210.3
41rh-mod syndrome10.3
42syringomyelia10.3
43systemic lupus erythematosus10.3
44neuronitis10.3
45gait apraxia10.3
46apraxia10.3
47communicating hydrocephalus10.3
48lupus erythematosus10.3
49meningioma10.3
50peritonitis10.3

Graphical network of the top 20 diseases related to Normal Pressure Hydrocephalus:



Diseases related to normal pressure hydrocephalus

Clinical Features for Normal Pressure Hydrocephalus

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46OMIM
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Clinical features from OMIM:

236690

Drugs & Therapeutics for Normal Pressure Hydrocephalus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Normal Pressure Hydrocephalus

Drug clinical trials:

Search ClinicalTrials for Normal Pressure Hydrocephalus

Search NIH Clinical Center for Normal Pressure Hydrocephalus

Search CenterWatch for Normal Pressure Hydrocephalus

Genetic Tests for Normal Pressure Hydrocephalus

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Anatomical Context for Normal Pressure Hydrocephalus

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32MalaCards
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MalaCards organs/tissues related to Normal Pressure Hydrocephalus:

32
Brain, Spinal cord, Testes, Thalamus, Eye, Bone, Cortex, Olfactory bulb, Pituitary

Animal Models for Normal Pressure Hydrocephalus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Normal Pressure Hydrocephalus:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9PYY, APOE, NPY, ACE, TGFBR2, TGFB1
2MP:00053818.4BDNF, APOE, NPY, GFAP, TGFBR2, TGFB1
3MP:00107718.4BDNF, APP, APOE, GAL, MAPT, PTGDS
4MP:00028738.4VIP, BDNF, PYY, APP, NPY, MAPT
5MP:00053898.3BDNF, APP, APOE, GAL, ACE, TGFB1
6MP:00053877.9VIP, APP, APOE, MAPT, GFAP, ACE
7MP:00053767.5APP, PYY, BDNF, VIP, APOE, NPY
8MP:00053787.4APOE, APP, PYY, BDNF, NPY, GAL
9MP:00107687.4VIP, BDNF, APP, APOE, MAPT, GFAP
10MP:00053847.3BDNF, APP, APOE, GAL, SNPH, MAPT
11MP:00036317.3BDNF, PYY, APP, APOE, NPY, GAL
12MP:00053866.5TGFB1, VIP, BDNF, PYY, APP, APOE

Publications for Normal Pressure Hydrocephalus

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Sources:
50PubMed
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Articles related to Normal Pressure Hydrocephalus:

(show top 50)    (show all 519)
idTitleAuthorsYear
1
Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus. (23037817)
2013
2
EEG and Neuronal Activity Topography analysis can predict effectiveness of shunt operation in idiopathic normal pressure hydrocephalus patients. (24273735)
2013
3
Commentary on cognitive and psychiatric symptoms associated with normal pressure hydrocephalus and frontotemporal dementia. (24241506)
2013
4
Abnormal cerebrospinal fluid (CSF) dynamics in Alzheimer's disease and normal pressure hydrocephalus: CSF-amyloid I^ precursor protein metabolites as possible biomarkers. (22934632)
2013
5
Emergency management of an acute tension pneumocephalus following ventriculoperitoneal shunt surgery for normal pressure hydrocephalus. (24101285)
2013
6
Predictors of the disappearance of triad symptoms in patients with idiopathic normal pressure hydrocephalus after shunt surgery. (23510566)
2013
7
A randomised trial of high and low pressure level settings on an adjustable ventriculoperitoneal shunt valve for idiopathic normal pressure hydrocephalus: results of the Dutch evaluation programme Strata shunt (DEPSS) trial. (23408069)
2013
8
What is the appropriate shunt system for normal pressure hydrocephalus? (22116436)
2012
9
Indications for endoscopic third ventriculostomy in normal pressure hydrocephalus. (22116437)
2012
10
Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus. (22343771)
2012
11
White matter alteration in idiopathic normal pressure hydrocephalus: tract-based spatial statistics study. (22016412)
2012
12
Cognitive disturbances and neuropsychological changes after surgical treatment in a cohort of 185 patients with idiopathic normal pressure hydrocephalus. (22382387)
2012
13
Olfactory bulb volume in patients with idiopathic normal pressure hydrocephalus. (22684151)
2012
14
Motor cortex disinhibition in normal-pressure hydrocephalus. (21999318)
2012
15
Counting-backward test for executive function in idiopathic normal pressure hydrocephalus. (22288385)
2012
16
Early evaluation of cerebral metabolic rate of glucose (CMRglu) with 18F-FDG PET/CT and clinical assessment in idiopathic normal pressure hydrocephalus (INPH) patients before and after ventricular shunt placement: preliminary experience. (21993525)
2012
17
MR volumetric changes after diagnostic CSF removal in normal pressure hydrocephalus. (22592285)
2012
18
Familial normal pressure hydrocephalus (NPH) with an autosomal-dominant inheritance: a novel subgroup of NPH. (21704338)
2011
19
Impact of duration of symptoms on CSF dynamics in idiopathic normal pressure hydrocephalus. (20849400)
2011
20
Fluid increase in the brain. Normal-pressure hydrocephalus. (22792566)
2011
21
Idiopathic normal-pressure hydrocephalus: temporal changes in ADC during cardiac cycle. (21900622)
2011
22
Cerebrospinal fluid dynamics and long-term survival of the Strata valve in idiopathic normal pressure hydrocephalus. (21039363)
2011
23
Normal-pressure hydrocephalus: is there a genetic predisposition? (21320833)
2011
24
Cerebrospinal fluid and blood flow in mild cognitive impairment and Alzheimer's disease: a differential diagnosis from idiopathic normal pressure hydrocephalus. (21349149)
2011
25
CSF neurotransmitter metabolites and neuropsychiatric symptomatology in patients with normal pressure hydrocephalus. (19046799)
2009
26
Radionuclide shunt patency study for evaluation of suspected ventriculoperitoneal shunt malfunction in adults with normal pressure hydrocephalus. (19404151)
2009
27
A preliminary study for investigating idiopatic normal pressure hydrocephalus by means of statistical parameters classification of intracranial pressure recordings. (19965228)
2009
28
Five-year incidence of surgery for idiopathic normal pressure hydrocephalus in Norway. (19832773)
2009
29
Upper extremity motor measures of Tap Test response in Normal Pressure Hydrocephalus. (19720451)
2009
30
Teaching NeuroImage: Prepontine-suprasellar arachnoid cyst presenting with signs of normal pressure hydrocephalus. (18250284)
2008
31
Objective assessment of gait in normal-pressure hydrocephalus. (17993991)
2008
32
The role of cerebrospinal fluid flow study using phase contrast MR imaging in diagnosing idiopathic normal pressure hydrocephalus. (19388301)
2008
33
Neuropsychological effects of shunt treatment in idiopathic normal pressure hydrocephalus. (18812964)
2008
34
Idiopathic normal-pressure hydrocephalus: clinical comorbidity correlated with cerebral biopsy findings and outcome of cerebrospinal fluid shunting. (17012342)
2007
35
Normal pressure hydrocephalus. (17659191)
2007
36
Predictive assessment of shunt effectiveness in patients with idiopathic normal pressure hydrocephalus by determining regional cerebral blood flow on 3D stereotactic surface projections. (17680175)
2007
37
Normal pressure hydrocephalus. (17226742)
2007
38
Clinical value of constructional skill testing in patients with secondary normal pressure hydrocephalus--two case reports. (17652920)
2007
39
Pathophysiology of cerebral circulatory disorders in idiopathic normal pressure hydrocephalus. (17652915)
2007
40
Proton magnetic resonance spectroscopy in patients with normal pressure hydrocephalus. (24351260)
2006
41
The diagnosis and treatment of idiopathic normal pressure hydrocephalus. (16932588)
2006
42
The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus. (16160426)
2005
43
Angiotensin I converting enzyme polymorphism effects in patients with normal pressure hydrocephalus syndrome before and after surgery. (15729525)
2005
44
The neuropsychology of normal pressure hydrocephalus (NPH). (16455521)
2005
45
Good outcome in patients with normal-pressure hydrocephalus and factors indicating poor prognosis. (16235677)
2005
46
Correlation between decreased ventricular size and positive clinical outcome following shunt placement in patients with normal-pressure hydrocephalus. (15200118)
2004
47
Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis. (12878439)
2003
48
Occurrence of subdural hematoma and resolution of gait disturbance in a patient treated with shunting for normal pressure hydrocephalus. (12140096)
2002
49
Signs, symptoms and course of normal pressure hydrocephalus in comparison with cerebral atrophy. (10550647)
1999
50
Response of cerebral blood flow and cerebrovascular reactivity to acetazolamide in patients with dementia and idiopathic normal-pressure hydrocephalus. (16918216)
1999

Genetic Variations for Normal Pressure Hydrocephalus

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Expression for genes affiliated with Normal Pressure Hydrocephalus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Normal Pressure Hydrocephalus

Search GEO for disease gene expression data for Normal Pressure Hydrocephalus.

Pathways for genes affiliated with Normal Pressure Hydrocephalus

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Sources:
37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 53Reactome, 52R&D Systems, 4Cell Signaling Technology
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Compounds for genes affiliated with Normal Pressure Hydrocephalus

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Normal Pressure Hydrocephalus according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7GFAP
2cycloheximide4410.2GAL, MAPT, PTGDS
3helospectin4410.1NPY, GAL, VIP
4secretoneurin4410.1VIP, GAL, NPY
5dsip4410.1PYY, NPY, GAL
6clonidine44 28 1112.0NPY, GAL, PYY
7trifluoroethanol44 1110.9MAPT, GAL, NPY, VIP
8thioflavine s449.8APP, APOE, MAPT
9atropine44 28 1111.8GAL, NPY, APP, PYY
10gnrh449.7GAL, VIP, PYY, BDNF, TGFBR2
11phosphoramidon44 1110.6VIP, APP, NPY, ACE
12tacrine44 1110.5MAPT, APOE, APP
13formate449.5APOE, APP, MAPT, GFAP
14donepezil44 11 2411.5MAPT, APP, APOE
156-hydroxydopamine449.4APP, VIP, GFAP, NPY, BDNF
16cocaine44 1110.4NPY, BDNF, PYY, GAL, GFAP
17streptozotocin449.4BDNF, NPY, GFAP, TGFB1, APOE
18capsaicin44 2810.4NPY, GAL, VIP, BDNF
19acth449.4PYY, BDNF, VIP, GAL, GFAP, NPY
20carbachol44 28 1111.3GAL, PYY, NPY, MAPT, VIP, APP
215-hydroxytryptamine449.3GFAP, NPY, PYY, APP, GAL, VIP
22octreotide44 59 28 1112.3VIP, PYY, NPY, GAL
23dopamine44 28 11 2412.2BDNF, PYY, APP, VIP, NPY, GFAP
24corticosterone44 59 2411.2GAL, GFAP, VIP, BDNF, APP, NPY
25nifedipine44 49 28 1112.2ACE, BDNF, TGFB1, NPY, VIP
26isoproterenol44 1110.2APP, VIP, PYY, GFAP, MAPT, NPY
27verapamil44 49 28 11 2413.2GFAP, TGFB1, VIP, APP, ACE
28nmda44 2810.1APP, APOE, MAPT, GFAP, BDNF
29tetrodotoxin44 59 2811.1GAL, VIP, BDNF, PYY, APOE, NPY
30kainate44 2810.1TGFB1, GFAP, MAPT, NPY, APOE, BDNF
31glucose449.1TGFBR2, GFAP, NPY, MAPT, GAL, PYY
32formaldehyde44 2410.1GFAP, NPY, APP, GAL, MAPT, TGFB1
33histamine44 28 2411.1PTGDS, TGFB1, GAL, NPY, BDNF, PYY
34nicotine44 49 28 1112.0APP, APOE, NPY, MAPT, TGFB1
35gaba449.0GFAP, VIP, BDNF, PYY, APP, GAL
36valine449.0VIP, MAPT, APOE, BDNF, APP
37norepinephrine44 11 2410.9VIP, PYY, BDNF, APP, NPY, GAL
38serine448.8PYY, TGFB1, GFAP, MAPT, GAL, APP
39adenylate448.8APP, NPY, GAL, VIP, GFAP, TGFBR2
40acetylcholine44 49 28 11 2412.8GAL, ACE, GFAP, MAPT, APP, BDNF
41actinomycin d448.8BDNF, APOE, APP, TGFB1, MAPT, TGFBR2
42arginine448.7NPY, GFAP, MAPT, GAL, APOE, APP
43choline44 11 2410.6VIP, BDNF, NPY, TGFB1, GFAP, GAL
44glutamine448.6APOE, VIP, APP, NPY, MAPT, TGFBR2
45cholesterol44 28 11 2411.5PTGDS, TGFBR2, ACE, GFAP, APOE, APP
46testosterone44 59 11 2411.4GAL, NPY, APOE, BDNF, VIP, APP
47glutamate448.4VIP, APOE, BDNF, NPY, GAL, MAPT
48alanine448.4VIP, APP, MAPT, APOE, NPY, GAL
49retinoic acid44 249.3TGFB1, TGFBR2, PTGDS, GFAP, MAPT, NPY
50creatinine448.2PTGDS, BDNF, APP, APOE, NPY, TGFB1

GO Terms for genes affiliated with Normal Pressure Hydrocephalus

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16Gene Ontology
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Cellular components related to Normal Pressure Hydrocephalus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.1TGFB1, SNPH, APOE, VIP
2extracellular spaceGO:0056158.0PYY, APOE, NPY, LRG1, ACE, PTGDS
3extracellular regionGO:0055767.1TGFB1, VIP, BDNF, PYY, APP, APOE

Biological processes related to Normal Pressure Hydrocephalus according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1common-partner SMAD protein phosphorylationGO:00718210.1TGFB1, TGFBR2
2response to cholesterolGO:07072310.0TGFB1, TGFBR2
3mononuclear cell proliferationGO:03294310.0ACE, TGFB1
4negative regulation of neuroblast proliferationGO:0074069.9BDNF, TGFB1
5myeloid dendritic cell differentiationGO:0430119.9TGFB1, TGFBR2
6axon cargo transportGO:0080889.9MAPT, APP
7pathway-restricted SMAD protein phosphorylationGO:0603899.8TGFBR2, TGFB1
8feeding behaviorGO:0076319.7GAL, NPY, PYY, BDNF
9agingGO:0075689.6TGFB1, TGFBR2, APOE
10negative regulation of blood vessel endothelial cell migrationGO:0435379.5APOE, TGFB1

Molecular functions related to Normal Pressure Hydrocephalus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.9MAPT, APOE
2neuropeptide hormone activityGO:0051849.3GAL, NPY, PYY, VIP

Products for genes affiliated with Normal Pressure Hydrocephalus

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  • Antibodies
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Sources for Normal Pressure Hydrocephalus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet