NPH
MCID: NRM002
MIFTS: 54

Normal Pressure Hydrocephalus (NPH) malady

Neuronal category

Summaries for Normal Pressure Hydrocephalus

Sources:
44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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NINDS:44 Normal pressure hydrocephalus (NPH) is an abnormal buildup of cerebrospinal fluid (CSF) in the brain's ventricles, or cavities. It occurs if the normal flow of CSF throughout the brain and spinal cord is blocked in some way. This causes the ventricles to enlarge, putting pressure on the brain. Normal pressure hydrocephalus can occur in people of any age, but it is most common in the elderly. It may result from a subarachnoid hemorrhage, head trauma, infection, tumor, or complications of surgery. However, many people develop NPH even when none of these factors are present. In these cases the cause of the disorder is unknown.

MalaCards: Normal Pressure Hydrocephalus, also known as hydrocephalus - normal pressure, is related to alzheimer's disease and type 2 diabetes mellitus. An important gene associated with Normal Pressure Hydrocephalus is VIP (vasoactive intestinal peptide), and among its related pathways are Glypican 1 network and Toll-like receptor signaling pathway. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Wikipedia:64 Normal pressure hydrocephalus (NPH), also termed symptomatic hydrocephalus, occurs when there is an... more...

Description from OMIM:47 236690

Aliases & Classifications for Normal Pressure Hydrocephalus

Sources:
8Disease Ontology, 44NINDS, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 47OMIM, 35MeSH, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
normal pressure hydrocephalus:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

normal pressure hydrocephalus 8 44 10 49
hydrocephalus - normal pressure 44
hydrocephalus, normal pressure 61
hydrocephalus normal pressure 45
chronic adult hydrocephalus 49
low pressure hydrocephalus 8
nph 49


External Ids:

Disease Ontology8 DOID:1572
OMIM47 236690
MeSH35 D006850
SNOMED-CT57 30753002, 69663004
ICD10 via Orphanet26 G91.2
ICD1025 G91.2

Related Diseases for Normal Pressure Hydrocephalus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Normal Pressure Hydrocephalus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1alzheimer's disease30.8BDNF, PYY, APP, APOE, NPY, GAL
2type 2 diabetes mellitus30.7ACE, GAL, APOE, PYY
3vascular disease30.5GFAP, PTGDS
4vascular dementia30.5MAPT, APOE, APP
5progressive supranuclear palsy30.4APOE, MAPT
6hypoglycemia30.4GAL, NPY, BDNF
7paraganglioma30.2GFAP, GAL
8obsessive-compulsive disorder30.2BDNF
9binswanger's disease30.2MAPT, GFAP
10arthritis30.2VIP, GAL, TGFB1
11frontotemporal dementia30.2APP, APOE, MAPT
12pick's disease30.2MAPT, APOE, APP
13parkinson's disease30.1BDNF, APP, APOE, GAL, MAPT
14cerebral atrophy10.5
15n syndrome10.5
16type 1 diabetes mellitus10.5
17maturity-onset diabetes of the young, type 110.5
18subcortical arteriosclerotic encephalopathy10.4
19diabetic ketoacidosis10.3
20maturity-onset diabetes of the young10.3
21immunodysregulation, polyendocrinopathy and enteropathy x-linked10.3
22brittle diabetes10.3
23maturity-onset diabetes of the young, type 210.3
24maturity-onset diabetes of the young, type 610.3
25epiphyseal dysplasia multiple with early-onset diabetes mellitus10.3
26type 1 diabetes10.3
27diabetes, type 210.3
28rh-mod syndrome10.3
29syringomyelia10.3
30systemic lupus erythematosus10.3
31gait apraxia10.3
32apraxia10.3
33hypoglycemic coma10.1
34pseudotumor cerebri10.1
35prosopagnosia10.1
36essential tremor10.1
37topographical agnosia10.1
38herpes zoster10.1
39cerebellopontine angle meningioma10.1
40agnosia10.1
41visual agnosia10.1
42herpes zoster ophthalmicus10.1
43nephronophthisis 110.1
44nephronophthisis 410.1
45nephronophthisis 310.1
46chorea10.1
47dementia - subcortical10.1
48tremor10.1
49hydrocephalus, autosomal dominant10.1
50sepsis10.1

Graphical network of the top 20 diseases related to Normal Pressure Hydrocephalus:



Diseases related to normal pressure hydrocephalus

Clinical Features for Normal Pressure Hydrocephalus

Sources:
47OMIM
See all sources

Clinical features from OMIM:

236690

Drugs & Therapeutics for Normal Pressure Hydrocephalus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Normal Pressure Hydrocephalus

Drug clinical trials:

Search ClinicalTrials for Normal Pressure Hydrocephalus

Search NIH Clinical Center for Normal Pressure Hydrocephalus

Search CenterWatch for Normal Pressure Hydrocephalus

Genetic Tests for Normal Pressure Hydrocephalus

Anatomical Context for Normal Pressure Hydrocephalus

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Normal Pressure Hydrocephalus:

33
Brain, Cortex, Spinal cord, Cingulate cortex, Olfactory bulb, Thalamus, Pituitary

Animal Models for Normal Pressure Hydrocephalus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Normal Pressure Hydrocephalus

Sources:
51PubMed
See all sources

Articles related to Normal Pressure Hydrocephalus:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Posturography in differential diagnosis of normal pressure hydrocephalus and brain atrophy. (22826082)
2013
2
Reversibility of brain morphology after shunt operations and preoperative clinical symptoms in patients with idiopathic normal pressure hydrocephalus. (23551411)
2013
3
Obstructive hydrocephalus mimicking a normal pressure condition as unusual presentation of basilar artery aneurysm: a case report. (22983308)
2013
4
Postural function in idiopathic normal pressure hydrocephalus before and after shunt surgery: a controlled study using computerized dynamic posturography (EquiTest). (23489444)
2013
5
Idiopathic normal-pressure hydrocephalus, cortical thinning, and the cerebrospinal fluid tap test. (23938354)
2013
6
Lumbosubarachnoid-lumboepidural shunting in patients with idiopathic normal-pressure hydrocephalus: surgical procedures and follow-up study of five cases. (24067779)
2013
7
White matter characteristics of idiopathic normal pressure hydrocephalus: a diffusion tensor tract-based spatial statistic study. (24067771)
2013
8
The influence of lumbar spinal drainage on diffusion parameters in patients with suspected normal pressure hydrocephalus using 3T MRI. (23996504)
2013
9
Shunt-responsive idiopathic normal pressure hydrocephalus patient with delayed improvement after tap test. (24379955)
2013
10
Third ventriculostomy in normal pressure hydrocephalus. (22381824)
2013
11
Lumboperitoneal shunts for the treatment of normal pressure hydrocephalus. (22705135)
2012
12
The value of the cerebrospinal fluid tap test for predicting shunt effectiveness in idiopathic normal pressure hydrocephalus. (22239832)
2012
13
Normal pressure hydrocephalus as an unusual presentation of supratentorial extraventricular space-occupying processes: report on two cases. (22666203)
2012
14
Normal pressure hydrocephalus. (22117181)
2012
15
Evans' index revisited: the need for an alternative in normal pressure hydrocephalus. (21221031)
2011
16
Diffusion tensor imaging reveals supplementary lesions to frontal white matter in idiopathic normal pressure hydrocephalus. (21336219)
2011
17
Effect of shunt operation on idiopathic normal pressure hydrocephalus patients in reducing caregiver burden: evidence from SINPHONI. (21625136)
2011
18
Cognitive, biochemical, and imaging profile of patients suffering from idiopathic normal pressure hydrocephalus. (21757406)
2011
19
Diagnostic intracranial pressure monitoring and surgical management in idiopathic normal pressure hydrocephalus: a 6-year review of 214 patients. (20023540)
2010
20
Detection of changes in cerebrospinal fluid space in idiopathic normal pressure hydrocephalus using voxel-based morphometry. (19847409)
2010
21
Predicting the outcome of shunt surgery in normal pressure hydrocephalus. (20495404)
2010
22
Normal pressure hydrocephalus after radiosurgery for sphenoid ridge meningioma. (19013812)
2009
23
Reversible grasp reflexes in normal pressure hydrocephalus. (19117665)
2009
24
Cognitive dysfunction in normal pressure hydrocephalus (NPH): a case report and review of the literature. (19271695)
2009
25
Normal pressure hydrocephalus. (19501723)
2009
26
Development of a quick reference table for setting programmable pressure valves in patients with idiopathic normal pressure hydrocephalus. (18948675)
2008
27
Narrow CSF space at high convexity and high midline areas in idiopathic normal pressure hydrocephalus detected by axial and coronal MRI. (17992524)
2008
28
Gait disturbance in normal pressure hydrocephalus: a clinical study. (17052947)
2007
29
Delayed and isolated intraventricular tension pneumocephalus after shunting for normal pressure hydrocephalus. (17272910)
2007
30
Evaluation and treatment of patients with suspected normal pressure hydrocephalus on long-term warfarin anticoagulation therapy. (17327794)
2007
31
Normal pressure hydrocephalus: a case report by a physician who is the patient. (17633954)
2007
32
Normal pressure hydrocephalus: new complications and concepts. (17636141)
2007
33
Is aqueductal stroke volume, measured with cine phase-contrast magnetic resonance imaging scans useful in predicting outcome of shunt surgery in suspected normal pressure hydrocephalus? (17228260)
2007
34
Characteristics and reversibility of dementia in Normal Pressure Hydrocephalus. (17726243)
2007
35
Normal pressure hydrocephalus. (16913194)
2006
36
Is it possible to optimize treatment of patients with idiopathic normal pressure hydrocephalus by implanting an adjustable Medos Hakim valve in combination with a Miethke shunt assistant? (16671490)
2006
37
Normal pressure hydrocephalus and polyneuropathy. (17100020)
2006
38
Development of guidelines for idiopathic normal-pressure hydrocephalus: introduction. (16160424)
2005
39
Does the ventricle size change after shunt operation of normal-pressure hydrocephalus? (16463860)
2005
40
Value of neuropsychological information for improved understanding of the patient with normal-pressure hydrocephalus. (16028753)
2005
41
Validation of the HIV Dementia Scale in an elderly cohort of patients with subcortical cognitive impairment caused by subcortical ischaemic vascular disease or a normal pressure hydrocephalus. (15087586)
2004
42
Predictors of outcome in patients with normal-pressure hydrocephalus. (14660879)
2004
43
Meningeal derived cerebrospinal fluid proteins in different forms of dementia: is a meningopathy involved in normal pressure hydrocephalus? (15489398)
2004
44
Normal pressure hydrocephalus (NPH): ischaemia, CSF stagnation or both. (15111447)
2004
45
Pattern of white matter regional cerebral blood flow and autoregulation in normal pressure hydrocephalus. (15033897)
2004
46
The reversibility of reduced cortical vein compliance in normal-pressure hydrocephalus following shunt insertion. (12592485)
2003
47
CSF galanin and cognition after shunt surgery in normal pressure hydrocephalus. (12933934)
2003
48
Normal pressure hydrocephalus found after anesthesia--a case report. (14768517)
2003
49
Differential diagnosis between normal pressure hydrocephalus and cerebral atrophy on computed tomography. (317615)
1979
50
Communicating hydrocephalus resembling cortical atrophy. An analysis of cases with application to the syndrome of "normal pressure hydrocephalus". (5302520)
1968

Genetic Variations for Normal Pressure Hydrocephalus

Expression for genes affiliated with Normal Pressure Hydrocephalus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Normal Pressure Hydrocephalus

Search GEO for disease gene expression data for Normal Pressure Hydrocephalus.

Pathways for genes affiliated with Normal Pressure Hydrocephalus

Sources:
38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 54Reactome, 53R&D Systems, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Normal Pressure Hydrocephalus

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB
See all sources

Compounds related to Normal Pressure Hydrocephalus according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7GFAP
2cycloheximide4510.2GAL, MAPT, PTGDS
3helospectin4510.1NPY, GAL, VIP
4secretoneurin4510.1VIP, GAL, NPY
5dsip4510.1PYY, NPY, GAL
6clonidine45 29 1112.0NPY, GAL, PYY
7trifluoroethanol45 1110.9MAPT, GAL, NPY, VIP
8thioflavine s459.8APP, APOE, MAPT
9atropine45 29 1111.8GAL, NPY, APP, PYY
10gnrh459.7GAL, VIP, PYY, BDNF, TGFBR2
11phosphoramidon45 1110.6VIP, APP, NPY, ACE
12tacrine45 1110.5MAPT, APOE, APP
13formate459.5APOE, APP, MAPT, GFAP
14donepezil45 11 2411.5MAPT, APP, APOE
156-hydroxydopamine459.4APP, VIP, GFAP, NPY, BDNF
16cocaine45 1110.4NPY, BDNF, PYY, GAL, GFAP
17streptozotocin459.4BDNF, NPY, GFAP, TGFB1, APOE
18capsaicin45 2910.4NPY, GAL, VIP, BDNF
19acth459.4PYY, BDNF, VIP, GAL, GFAP, NPY
20carbachol45 29 1111.3GAL, PYY, NPY, MAPT, VIP, APP
215-hydroxytryptamine459.3GFAP, NPY, PYY, APP, GAL, VIP
22octreotide45 60 29 1112.3VIP, PYY, NPY, GAL
23dopamine45 29 11 2412.2BDNF, PYY, APP, VIP, NPY, GFAP
24corticosterone45 60 2411.2GAL, GFAP, VIP, BDNF, APP, NPY
25nifedipine45 50 29 1112.2ACE, BDNF, TGFB1, NPY, VIP
26isoproterenol45 1110.2APP, VIP, PYY, GFAP, MAPT, NPY
27verapamil45 50 29 11 2413.2GFAP, TGFB1, VIP, APP, ACE
28nmda45 2910.1APP, APOE, MAPT, GFAP, BDNF
29tetrodotoxin45 60 2911.1GAL, VIP, BDNF, PYY, APOE, NPY
30kainate45 2910.1TGFB1, GFAP, MAPT, NPY, APOE, BDNF
31glucose459.1TGFBR2, GFAP, NPY, MAPT, GAL, PYY
32formaldehyde45 2410.1GFAP, NPY, APP, GAL, MAPT, TGFB1
33histamine45 29 2411.1PTGDS, TGFB1, GAL, NPY, BDNF, PYY
34nicotine45 50 29 1112.0APP, APOE, NPY, MAPT, TGFB1
35gaba459.0GFAP, VIP, BDNF, PYY, APP, GAL
36valine459.0VIP, MAPT, APOE, BDNF, APP
37norepinephrine45 11 2410.9VIP, PYY, BDNF, APP, NPY, GAL
38serine458.8PYY, TGFB1, GFAP, MAPT, GAL, APP
39adenylate458.8APP, NPY, GAL, VIP, GFAP, TGFBR2
40acetylcholine45 50 29 11 2412.8GAL, ACE, GFAP, MAPT, APP, BDNF
41actinomycin d458.8BDNF, APOE, APP, TGFB1, MAPT, TGFBR2
42arginine458.7NPY, GFAP, MAPT, GAL, APOE, APP
43choline45 11 2410.6VIP, BDNF, NPY, TGFB1, GFAP, GAL
44glutamine458.6APOE, VIP, APP, NPY, MAPT, TGFBR2
45cholesterol45 29 11 2411.5PTGDS, TGFBR2, ACE, GFAP, APOE, APP
46testosterone45 60 11 2411.4GAL, NPY, APOE, BDNF, VIP, APP
47glutamate458.4VIP, APOE, BDNF, NPY, GAL, MAPT
48alanine458.4VIP, APP, MAPT, APOE, NPY, GAL
49retinoic acid45 249.3TGFB1, TGFBR2, PTGDS, GFAP, MAPT, NPY
50creatinine458.2PTGDS, BDNF, APP, APOE, NPY, TGFB1

GO Terms for genes affiliated with Normal Pressure Hydrocephalus

Sources:
16Gene Ontology
See all sources

Cellular components related to Normal Pressure Hydrocephalus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.1TGFB1, SNPH, APOE, VIP
2extracellular spaceGO:0056158.0PYY, APOE, NPY, LRG1, ACE, PTGDS
3extracellular regionGO:0055767.1TGFB1, VIP, BDNF, PYY, APP, APOE

Biological processes related to Normal Pressure Hydrocephalus according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1common-partner SMAD protein phosphorylationGO:00718210.1TGFB1, TGFBR2
2response to cholesterolGO:07072310.0TGFB1, TGFBR2
3mononuclear cell proliferationGO:03294310.0ACE, TGFB1
4negative regulation of neuroblast proliferationGO:0074069.9TGFB1, BDNF
5myeloid dendritic cell differentiationGO:0430119.9TGFB1, TGFBR2
6axon cargo transportGO:0080889.9MAPT, APP
7negative regulation of blood vessel endothelial cell migrationGO:0435379.7TGFB1, APOE
8feeding behaviorGO:0076319.7PYY, NPY, GAL, BDNF
9agingGO:0075689.6APOE, TGFB1, TGFBR2
10pathway-restricted SMAD protein phosphorylationGO:0603899.6TGFB1, TGFBR2

Molecular functions related to Normal Pressure Hydrocephalus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.9MAPT, APOE
2neuropeptide hormone activityGO:0051849.3GAL, NPY, PYY, VIP

Products for genes affiliated with Normal Pressure Hydrocephalus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Normal Pressure Hydrocephalus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet