NPH
MCID: NRM002
MIFTS: 50

Normal Pressure Hydrocephalus (NPH) malady

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Normal Pressure Hydrocephalus

Aliases & Descriptions for Normal Pressure Hydrocephalus:

Name: Normal Pressure Hydrocephalus 12 51 56 14
Hydrocephalus, Normal Pressure 42 69
Hydrocephalus - Normal Pressure 51
Hydrocephalus Normal Pressure 52
Chronic Adult Hydrocephalus 56
Low Pressure Hydrocephalus 12
Nph 56

Characteristics:

Orphanet epidemiological data:

56
normal pressure hydrocephalus
Inheritance: Not applicable; Age of onset: Adult;

HPO:

32
normal pressure hydrocephalus:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:1572
ICD10 33 G91.2
MeSH 42 D006850
SNOMED-CT 64 30753002 69663004
Orphanet 56 ORPHA314928
UMLS via Orphanet 70 C0020258
ICD10 via Orphanet 34 G91.2
UMLS 69 C0020258

Summaries for Normal Pressure Hydrocephalus

NINDS : 51 Normal pressure hydrocephalus (NPH) is an abnormal buildup of cerebrospinal fluid (CSF) in the brain's ventricles, or cavities. It occurs if the normal flow of CSF throughout the brain and spinal cord is blocked in some way. This causes the ventricles to enlarge, putting pressure on the brain. Normal pressure hydrocephalus can occur in people of any age, but it is most common in the elderly. It may result from a subarachnoid hemorrhage, head trauma, infection, tumor, or complications of surgery. However, many people develop NPH even when none of these factors are present. In these cases the cause of the disorder is unknown.

MalaCards based summary : Normal Pressure Hydrocephalus, also known as hydrocephalus, normal pressure, is related to hydrocephalus and nephronophthisis, and has symptoms including gait disturbance, bowel incontinence and global developmental delay. An important gene associated with Normal Pressure Hydrocephalus is PMPCA (Peptidase, Mitochondrial Processing Alpha Subunit), and among its related pathways/superpathways are Neuroscience and A-beta Pathways: Uptake and Degradation. The drugs Citalopram and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 71 Normal pressure hydrocephalus (NPH), also termed Hakim\'s syndrome and symptomatic hydrocephalus, is a... more...

Related Diseases for Normal Pressure Hydrocephalus

Diseases related to Normal Pressure Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
id Related Disease Score Top Affiliating Genes
1 hydrocephalus 11.6
2 nephronophthisis 11.2
3 glomerulosclerosis, focal segmental, 2 10.9
4 nephronophthisis 4 10.8
5 nephronophthisis 1, juvenile 10.8
6 nephronophthisis 3 10.8
7 nephrotic syndrome, type 1 10.7
8 glomerulosclerosis, focal segmental, 4 10.7
9 glomerulosclerosis, focal segmental, 3 10.7
10 glomerulosclerosis, focal segmental, 5 10.7
11 glomerulosclerosis, focal segmental, 1 10.7
12 cerebritis 10.4
13 dementia 10.3
14 cockayne syndrome type i 10.2 NPY VIP
15 bone dysplasia azouz type 10.1 APOE APP VIP
16 ichthyosis lamellar 2 10.1 APOE APP PTGDS
17 ectodermal dysplasia mental retardation syndactyly 10.1 APP PSEN1
18 porencephaly 2 10.1 APOE APP
19 urethritis 10.1 APOE PSEN1
20 pulmonary systemic sclerosis 10.1 APOE PTGDS SERPINA3
21 foxp2-related speech and language disorders 10.1 APP PSEN1
22 anaplastic ependymoma 10.0 TTR VIP
23 pick disease 10.0 APP PSEN1
24 intracranial structure hemangioma 10.0 APP PSEN1
25 severe congenital nemaline myopathy 10.0 APOE PSEN1
26 allergic bronchopulmonary aspergillosis, familial 10.0 APOE APP SERPINA3
27 arthrogryposis, lethal, with anterior horn cell disease 10.0 APOE TTR
28 alzheimer disease 10.0
29 cerebral atrophy 10.0
30 encephalopathy 10.0
31 cardiomyopathy, dilated, 1v 10.0 APP PSEN1
32 encephalitozoonosis 10.0 APOE APP PSEN1
33 coenzyme q10 deficiency, primary, 1 10.0 APOE APP PSEN1
34 cardiomyopathy, dilated, 1u 10.0 APOE APP PSEN1
35 clear cell adenoma 10.0 HCRT PSEN1
36 atrial septal defect 9 9.9 APP HCRT
37 personality disorder 9.9 APOE HCRT PSEN1
38 eumycotic mycetoma 9.9 APOE APP PSEN1
39 arachnoiditis 9.9
40 hemopericardium 9.9 NPY TTR
41 subcortical arteriosclerotic encephalopathy 9.9
42 syringomyelia 9.9
43 vascular dementia 9.9
44 intracranial hypertension 9.9
45 arachnoid cysts 9.9
46 meckel syndrome 10 9.8 APOE APP PSEN1 SERPINA3
47 contagious pustular dermatitis 9.8 APOE APP PSEN1 SERPINA3
48 van maldergem syndrome 2 9.8 APP PSEN1 TTR
49 neuronitis 9.8
50 systemic lupus erythematosus 9.8

Graphical network of the top 20 diseases related to Normal Pressure Hydrocephalus:



Diseases related to Normal Pressure Hydrocephalus

Symptoms & Phenotypes for Normal Pressure Hydrocephalus

Human phenotypes related to Normal Pressure Hydrocephalus:

32 (show all 6)
id Description HPO Frequency HPO Source Accession
1 gait disturbance 32 HP:0001288
2 bowel incontinence 32 HP:0002607
3 global developmental delay 32 HP:0001263
4 dementia 32 HP:0000726
5 urinary incontinence 32 HP:0000020
6 normal pressure hydrocephalus 32 HP:0002343

MGI Mouse Phenotypes related to Normal Pressure Hydrocephalus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.86 ADORA2A APOE APP HCRT NPY PSEN1
2 homeostasis/metabolism MP:0005376 9.81 VIP ADORA2A APOE APP HCRT NPY
3 nervous system MP:0003631 9.5 ADORA2A APOE APP HCRT NPY PSEN1
4 respiratory system MP:0005388 9.02 ADORA2A APOE HCRT PSEN1 VIP

Drugs & Therapeutics for Normal Pressure Hydrocephalus

Drugs for Normal Pressure Hydrocephalus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4 59729-33-8 2771
2 Cholinergic Agents Phase 4
3 Cholinergic Antagonists Phase 4
4 Muscarinic Antagonists Phase 4
5 Neurotransmitter Agents Phase 4
6 Neurotransmitter Uptake Inhibitors Phase 4
7
Serotonin Phase 4 50-67-9 5202
8 Serotonin Agents Phase 4
9 Serotonin Uptake Inhibitors Phase 4
10
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
11 Anesthetics Phase 2, Phase 3
12 Anti-Infective Agents, Local Phase 2, Phase 3
13 Pharmaceutical Solutions Phase 2, Phase 3
14 Anticonvulsants Phase 3
15 Carbonic Anhydrase Inhibitors Phase 3
16 diuretics Phase 3
17 Natriuretic Agents Phase 3
18 Mitogens

Interventional clinical trials:

(show all 42)
id Name Status NCT ID Phase
1 Normal Pressure Hydrocephalus (NPH) Registry Completed NCT00233701 Phase 4
2 Efficacy and Safety of Selective Serotonin Reuptake Inhibitor (SSRI) in Overactive Bladder Patients Completed NCT00902421 Phase 4
3 ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH Patients Completed NCT01323764 Phase 4
4 ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients Withdrawn NCT00793416 Phase 4
5 Clinical Value of Noninvasive Intracranial Pressure Measurement Unknown status NCT02130219 Phase 2, Phase 3
6 PET Imaging of Brain Amyloid in Normal Pressure Hydrocephalus Completed NCT01053312 Phase 3
7 A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System. Completed NCT00196196 Phase 3
8 Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure Hydrocephalus Terminated NCT01092546 Phase 3
9 ETV Versus Shunt Surgery in Normal Pressure Hydrocephalus Terminated NCT00946127 Phase 3
10 Normal Pressure Hydrocephalus Treatment by Acetazolamide Terminated NCT02163330 Phase 3
11 Study to Evaluate Efficacy of Shunt Operation for Idiopathic Normal Pressure Hydrocephalus Completed NCT00221091 Phase 2
12 Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus Unknown status NCT01618500
13 European Study on Prediction of Outcome in Patients With Idiopathic Normal Pressure Hydrocephalus Unknown status NCT00874198
14 Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia Unknown status NCT00494689
15 Magnetic Resonance Elastography in Hydrocephalus Unknown status NCT02230124
16 Cerebral Blood Circulation in Patients With Posterior Fossa Brain Tumor Unknown status NCT01476670
17 A Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure Hydrocephalus Completed NCT01570257
18 Predictive Value of Flow MRI in Normal Pressure Hydrocephalus Surgery Completed NCT01815775 Early Phase 1
19 Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus Completed NCT00600795
20 Computerized Neuropsychology in Idiopathic Normal Pressure Hydrocephalus (INPH) Completed NCT01265251
21 A Study Comparing Shunt Placement Versus Endoscopic Third Ventriculostomy in the Treatment of Hydrocephalus Completed NCT01115270
22 Vascular Risk Factors in INPH-patients Completed NCT01850914
23 Cerebrospinal Fluid Proteome in Hydrocephalus Completed NCT02016352
24 Improved Analysis Methods for Infusion Tests Completed NCT01319136
25 Intracranial Pressure Waves Via Lumbar Puncture Completed NCT01374048
26 Value of Radionuclide Cisternography Completed NCT02876614
27 Comparison of Continuous Noninvasive and Invasive Intracranial Pressure Measurement--Celda Infusion Subprotocol Completed NCT01976559
28 Reference Values of Cerebrospinal Fluid Outflow Resistance and Intracranial Pressure in Healthy Elderly Completed NCT01188382
29 Establishing the Physiology of Syringomyelia Completed NCT00001327
30 The Brain Structure and Neural Network Changing the Before and After Ventriculo-peritoneal Shunting in the Normal Pressure Hydrocephalus Patients Recruiting NCT03092804
31 Flow MRI in Normal Pressure Hydrocephalus Recruiting NCT01909960
32 Effects of Physical Training in iNPH Recruiting NCT02659111
33 A Randomized Cross-over Study for Normal Pressure Hydrocephalus Recruiting NCT01798641
34 Novel Parameters for the Prediction of Ventriculoperitoneal Shunting Efficacy in Patients With iNPH Recruiting NCT02495610
35 Noninvasive Intracranial Pressure and Hydrocephalus Patients Enrolling by invitation NCT02404740
36 Using Cerebrospinal Fluid Dynamics to Optimize Treatment of Idiopathic Normal Pressure Hydrocephalus Not yet recruiting NCT03076723
37 An Evaluation of Non-Invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an Intraparenchymal Pressure Monitoring Device Suspended NCT02773888
38 Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus Terminated NCT00613886
39 Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus (INPH) Terminated NCT00727142
40 Anterior Pituitary Function in Patients With Hydrocephalus Terminated NCT00149721
41 Prognostic Value of Aβ Imaging in NPH Prior to Shunt Placement Terminated NCT01834625
42 Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in Life Withdrawn NCT01377805

Search NIH Clinical Center for Normal Pressure Hydrocephalus

Cochrane evidence based reviews: hydrocephalus, normal pressure

Genetic Tests for Normal Pressure Hydrocephalus

Anatomical Context for Normal Pressure Hydrocephalus

MalaCards organs/tissues related to Normal Pressure Hydrocephalus:

39
Brain, Testes, Spinal Cord, Thalamus, Bone, Pituitary, Olfactory Bulb

Publications for Normal Pressure Hydrocephalus

Articles related to Normal Pressure Hydrocephalus:

(show top 50) (show all 631)
id Title Authors Year
1
Clinical Correlation of Abnormal Findings on Magnetic Resonance Elastography in Idiopathic Normal Pressure Hydrocephalus. ( 28063896 )
2017
2
Decreased Expression of hsa-miR-4274 inA Cerebrospinal Fluid of Normal Pressure Hydrocephalus Mimics with Parkinsonian Syndromes. ( 27911315 )
2017
3
The clinical effect of postoperative hyperbaric oxygen therapy on idiopathic normal pressure hydrocephalus:A retrospective and comparative analysis of 61 patients with ventriculoperitoneal shunt. ( 28502690 )
2017
4
Supplementary tests in idiopathic normal pressure hydrocephalus: a single center experience with a combined lumbar infusion test and tap test. ( 28089835 )
2017
5
Asymmetric and Upper-Body Parkinsonism in Patients with Idiopathic Normal-Pressure Hydrocephalus. ( 28516741 )
2017
6
Spectral Domain-Optical Coherence Tomography As a New Diagnostic Marker for Idiopathic Normal Pressure Hydrocephalus. ( 28507532 )
2017
7
Neurite orientation dispersion and density imaging for evaluation of corticospinal tract in idiopathic normal pressure hydrocephalus. ( 27787666 )
2017
8
Diagnosis of Normal-Pressure Hydrocephalus: Use of Traditional Measures in the Era of Volumetric MR Imaging. ( 28498794 )
2017
9
Olfactory ability in normal pressure hydrocephalus as compared to Alzheimer's disease and healthy controls. ( 28017216 )
2017
10
Cerebrospinal fluid AI^42, t-tau, and p-tau levels in the differential diagnosis of idiopathic normal-pressure hydrocephalus: a systematic review and meta-analysis. ( 28486988 )
2017
11
Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-I^ Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. ( 27802227 )
2017
12
Associations of intracranial pressure with brain biopsy, radiological findings, and shunt surgery outcome in patients with suspected idiopathic normal pressure hydrocephalus. ( 27878614 )
2017
13
Timing of surgical treatment for idiopathic normal pressure hydrocephalus: association between treatment delay and reduced short-term benefit. ( 27581314 )
2016
14
The Prediction of Shunt Response in Idiopathic Normal-Pressure Hydrocephalus Based on Intracranial Pressure Monitoring and Lumbar Infusion. ( 27165919 )
2016
15
Clinical outcomes in the surgical treatment of idiopathic normal pressure hydrocephalus. ( 26935749 )
2016
16
The effect of shunt surgery on neuropsychological performance in normal pressure hydrocephalus: a systematic review and meta-analysis. ( 27017344 )
2016
17
Choroidal fissure acts as an overflow device in cerebrospinal fluid drainage: morphological comparison between idiopathic and secondary normal-pressure hydrocephalus. ( 27941913 )
2016
18
The Effect of Spinal Tap Test on Different Sensory Modalities of Postural Stability in Idiopathic Normal Pressure Hydrocephalus. ( 27790243 )
2016
19
Typical Symptoms of Normal-Pressure Hydrocephalus Caused by Choroid Plexus Papilloma in the Cerebellopontine Angle. ( 27913261 )
2016
20
Normal pressure hydrocephalus and parkinsonism: preliminary data on neurosurgical and neurological treatment. ( 26970480 )
2016
21
NPH Log: Validation of a New Assessment Tool Leading to Earlier Diagnosis of Normal Pressure Hydrocephalus. ( 27489752 )
2016
22
Neurosyphilis With Normal Pressure Hydrocephalus and Dementia Paralytica: Serial Clinical, Laboratory and Radiological Correlations in the 21st Century. ( 27761229 )
2016
23
Magnetic Resonance Imaging of Normal Pressure Hydrocephalus. ( 27063662 )
2016
24
Imaging normal pressure hydrocephalus: theories, techniques, and challenges. ( 27581307 )
2016
25
Relative Position of the Third Characteristic Peak of the Intracranial Pressure Pulse Waveform Morphology Differentiates Normal-Pressure Hydrocephalus Shunt Responders and Nonresponders. ( 27165933 )
2016
26
Disappearance of the Hummingbird Sign after Shunt Surgery in a Case of Idiopathic Normal Pressure Hydrocephalus. ( 27041171 )
2016
27
Characterization of lower urinary tract symptoms in patients with idiopathic normal pressure hydrocephalus. ( 27490149 )
2016
28
Longitudinal Metabolite Profiling of Cerebrospinal Fluid in Normal Pressure Hydrocephalus Links Brain Metabolism with Exercise-Induced VEGF Production and Clinical Outcome. ( 27084769 )
2016
29
Familial idiopathic normal pressure hydrocephalus. ( 27538594 )
2016
30
Relationship between intracranial pressure and phase contrast cine MRI derived measures of intracranial pulsations in idiopathic normal pressure hydrocephalus. ( 27519145 )
2016
31
Normal-Pressure Hydrocephalus Case Report: Self-Documented Over 8 Years with the Author's Observations. ( 27165936 )
2016
32
Diagnosis and Treatment of Idiopathic Normal Pressure Hydrocephalus. ( 27042909 )
2016
33
Measuring changes in the optic nerve sheath diameter in patients with idiopathic normal-pressure hydrocephalus: a useful diagnostic supplement to spinal tap tests. ( 27981690 )
2016
34
Apathy and higher level of gait control in normal pressure hydrocephalus. ( 27965058 )
2016
35
Normal pressure hydrocephalus: Increase of utricular input in responders to spinal tap test. ( 27072102 )
2016
36
Executive functioning pattern as a prognostic indicator for shunt implantation surgery in patients with normal pressure hydrocephalus - A preliminary report. ( 26969565 )
2016
37
Diagnostic ability of cerebrospinal fluid tap test for predicting shunt responsiveness in patients with normal pressure hydrocephalus. ( 27772746 )
2016
38
Investigation and clinical applications of muscle strength change in cerebrospinal fluid tap test in cases of idiopathic normal pressure hydrocephalus: A retrospective study. ( 27871440 )
2016
39
Walking assessment after lumbar puncture in normal-pressure hydrocephalus: a delayed improvement over 3 days. ( 26991388 )
2016
40
Surgical management of idiopathic normal pressure hydrocephalus: a trial of a trial. ( 27626959 )
2016
41
Assessment of response to cerebrospinal fluid tap test for normal pressure hydrocephalus: how we do it. ( 27530884 )
2016
42
Asymmetric and Upper Body Parkinsonism in Patients with Idiopathic Normal-Pressure Hydrocephalus. ( 27486933 )
2016
43
Early and delayed assessments of quantitative gait measures to improve the tap test as a predictor of shunt effectiveness in idiopathic normal pressure hydrocephalus. ( 27876063 )
2016
44
Bulbar dysfunction in normal pressure hydrocephalus: a prospective study. ( 27581311 )
2016
45
Disproportionately Enlarged Subarachnoid Space Hydrocephalus in Idiopathic Normal-Pressure Hydrocephalus and Its Implication in Pathogenesis. ( 27165923 )
2016
46
Early Idiopathic Normal Pressure Hydrocephalus Patients With Neuropsychological Impairment Are Associated With Increased Fractional Anisotropy in the Anterior Thalamic Nucleus. ( 27175677 )
2016
47
Efficacy of Lumboperitoneal Shunting in Patients with Normal Pressure Hydrocephalus. ( 27858384 )
2016
48
Segmentation and labeling of the ventricular system in normal pressure hydrocephalus using patch-based tissue classification and multi-atlas labeling. ( 27199501 )
2016
49
Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus. ( 27743250 )
2016
50
Cerebrospinal fluid levels of tumor necrosis factor alpha and aquaporin 1 in patients with mild cognitive impairment and idiopathic normal pressure hydrocephalus. ( 27155076 )
2016

Variations for Normal Pressure Hydrocephalus

ClinVar genetic disease variations for Normal Pressure Hydrocephalus:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 PMPCA NM_015160.2(PMPCA): c.1066G> A (p.Gly356Ser) single nucleotide variant Pathogenic rs768643552 GRCh37 Chromosome 9, 139313082: 139313082
2 PMPCA NM_015160.2(PMPCA): c.1129G> A (p.Ala377Thr) single nucleotide variant Pathogenic rs753611141 GRCh38 Chromosome 9, 136418847: 136418847

Expression for Normal Pressure Hydrocephalus

Search GEO for disease gene expression data for Normal Pressure Hydrocephalus.

Pathways for Normal Pressure Hydrocephalus

Pathways related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.61 APOE APP HCRT NPY PSEN1 VIP
2 10.8 APOE APP
3 10.79 APOE APP PSEN1
4 10.57 APP PSEN1

GO Terms for Normal Pressure Hydrocephalus

Cellular components related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Golgi apparatus GO:0005794 9.8 APOE APP NPY PSEN1 PTGDS
2 extracellular region GO:0005576 9.76 APOE APP HCRT NPY PTGDS SERPINA3
3 perinuclear region of cytoplasm GO:0048471 9.73 APP HCRT PSEN1 PTGDS
4 extracellular space GO:0005615 9.5 APOE APP NPY PMPCA PTGDS SERPINA3
5 dendritic shaft GO:0043198 9.37 APP PSEN1
6 smooth endoplasmic reticulum GO:0005790 9.32 APP PSEN1
7 ciliary rootlet GO:0035253 9.26 APP PSEN1
8 rough endoplasmic reticulum GO:0005791 8.92 APP HCRT PSEN1 PTGDS

Biological processes related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.65 ADORA2A APOE PSEN1
2 response to oxidative stress GO:0006979 9.63 APOE APP PSEN1
3 blood circulation GO:0008015 9.58 ADORA2A NPY
4 feeding behavior GO:0007631 9.58 HCRT NPY
5 neuron apoptotic process GO:0051402 9.57 APP PSEN1
6 protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205 9.56 ADORA2A HCRT
7 eating behavior GO:0042755 9.55 ADORA2A HCRT
8 synaptic transmission, cholinergic GO:0007271 9.54 ADORA2A APOE
9 positive regulation of dendritic spine development GO:0060999 9.52 APOE PSEN1
10 vasodilation GO:0042311 9.51 ADORA2A APOE
11 regulation of protein binding GO:0043393 9.49 APP PSEN1
12 amyloid precursor protein metabolic process GO:0042982 9.43 APOE PSEN1
13 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway GO:0010579 9.4 ADORA2A VIP
14 cellular response to beta-amyloid GO:1904646 9.37 APP PSEN1
15 regulation of synaptic plasticity GO:0048167 9.33 ADORA2A APP PSEN1
16 regulation of epidermal growth factor-activated receptor activity GO:0007176 9.32 APP PSEN1
17 astrocyte activation involved in immune response GO:0002265 9.26 APP PSEN1
18 cellular protein metabolic process GO:0044267 9.02 ADORA2A APOE APP PSEN1 TTR
19 smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 8.96 APP PSEN1

Molecular functions related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 NPY TTR VIP
2 neuropeptide hormone activity GO:0005184 8.8 HCRT NPY VIP

Sources for Normal Pressure Hydrocephalus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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