MCID: NRW001
MIFTS: 43

Norwegian Scabies

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Norwegian Scabies

MalaCards integrated aliases for Norwegian Scabies:

Name: Norwegian Scabies 12 50 14
Crusted Scabies 12 50 69
Seven Year Itch 50

Classifications:



External Ids:

Disease Ontology 12 DOID:14374
NCIt 47 C34855
UMLS 69 C0028425

Summaries for Norwegian Scabies

NIH Rare Diseases : 50 crusted scabies (also called norwegian scabies) is a severe form of scabies that most often occurs in people who have a weakened immune system or a neurological disease, the elderly, the disabled, or those who are mentally impaired. the condition is characterized by thick crusts of skin that contain large numbers of scabies mites and eggs. the usual features of scabies (itching and a rash) may be absent. crusted scabies is very contagious and can spread easily both by direct skin-to-skin contacts and through contaminated items such as clothing, bedding, and furniture. it is caused by superinfestation with sarcoptes scabiei var hominis, but why the crusted scabies develops is unknown.  people with crusted scabies should receive quick and aggressive medical treatment for their infestation to prevent outbreaks of scabies.ivermectin is commonly used for treatment.   last updated: 12/10/2016

MalaCards based summary : Norwegian Scabies, also known as crusted scabies, is related to lymphoma and rheumatoid arthritis. An important gene associated with Norwegian Scabies is KCNE1 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 1), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. The drugs Ivermectin and Permethrin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and liver, and related phenotypes are shRNA abundance <= 50% and cellular

Disease Ontology : 12 A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.

Related Diseases for Norwegian Scabies

Diseases related to Norwegian Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
id Related Disease Score Top Affiliating Genes
1 lymphoma 30.0 CD40LG CD79A FOXP3 IL5
2 rheumatoid arthritis 29.5 CD40LG CD79A FOXP3 TGFB1 TNFRSF1B
3 alcoholic neuropathy 10.9 CD40LG CD79A
4 calloso-genital dysplasia 10.9 CD40LG CD79A
5 variola major 10.9 CD40LG CD79A
6 mu chain disease 10.9 CD40LG CD79A
7 rabies 10.9 CD40LG CD79A
8 familial retinoblastoma 10.9 CD40LG CD79A
9 anti-basement membrane glomerulonephritis 10.9 CD40LG CD79A
10 microinvasive cervical squamous cell carcinoma 10.9 CD40LG CD79A
11 fetal erythroblastosis 10.9 CD40LG CD79A
12 spinal canal and spinal cord meningioma 10.9 CD40LG CD79A
13 trichostrongyloidiasis 10.9 CD40LG CD79A
14 leukodystrophy 10.8 CD40LG CD79A
15 retinal microaneurysm 10.8 CD40LG CD79A
16 heart septal defect 10.8 CD40LG CD79A
17 cryptorchidism arachnodactyly mental retardation 10.8 CD40LG CD79A
18 acute kidney tubular necrosis 10.8 CD40LG CD79A
19 spoan syndrome 10.8 CD40LG STAT1
20 secretory meningioma 10.8 CD40LG CD79A
21 hodgkin's lymphoma, nodular sclerosis 10.8 CD40LG CD79A
22 imperforate oropharynx-costo vetebral anomalies 10.8 CD40LG CD79A
23 malignant otitis externa 10.8 CD40LG CD79A
24 transient hypogammaglobulinemia 10.8 CD40LG CD79A
25 benign epilepsy with centrotemporal spikes 10.8 CD40LG CD79A
26 tongue cancer 10.8 CD40LG CD79A
27 scabies 10.8
28 hydrops of gallbladder 10.8 CD40LG CD79A
29 gamma heavy chain disease 10.8 CD40LG CD79A
30 diabetic angiopathy 10.8 CD40LG CD79A
31 rosacea conjunctivitis 10.8 CD40LG CD79A
32 viral meningitis 10.7 CD40LG CD79A
33 heart fibrosarcoma 10.7 CD40LG CD79A
34 extrapulmonary tuberculosis 10.7 CD40LG CD79A MT-CO1
35 alopecia areata 10.7 CD40LG CD79A
36 kidney carcinoma in situ 10.7 CD40LG CD79A
37 acute interstitial pneumonia 10.7 CD40LG CD79A MT-CO1
38 cardiac tuberculosis 10.7 CD40LG CD79A
39 cyclothymic disorder 10.6 IL5 KCNE1 TWIST1
40 dumping syndrome 10.6 CD40LG CD79A
41 motor peripheral neuropathy 10.6 CD40LG CD79A STAT1
42 leiomyosarcoma 10.6 CD40LG CD79A
43 abdominal tuberculosis 10.6 CD40LG IL5 MT-CO1
44 periarthritis 10.6 CD40LG CD79A
45 angiomyoma 10.6 CD40LG CD79A IL5
46 lung disease 10.6 CD40LG TNFRSF1B
47 solid pattern testicular yolk sac tumor 10.6 CD40LG CD79A FOXP3
48 pelvic varices 10.6 CD40LG CD79A IL5
49 discitis 10.6 CD40LG CD79A TNFRSF1B
50 hypertrophic elongation of cervix 10.6 CD40LG CD79A TNFRSF1B

Graphical network of the top 20 diseases related to Norwegian Scabies:



Diseases related to Norwegian Scabies

Symptoms & Phenotypes for Norwegian Scabies

GenomeRNAi Phenotypes related to Norwegian Scabies according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.36 TGFB1 TNFRSF1B TRIM33 TWIST1 WWOX ATP2A2

MGI Mouse Phenotypes related to Norwegian Scabies:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 ATP2A2 CD40LG CD79A FOXP3 HPGDS MT-CO1
2 homeostasis/metabolism MP:0005376 10.31 ANO1 NKX2-1 STAT1 TGFB1 TNFRSF1B WWOX
3 growth/size/body region MP:0005378 10.29 ANO1 ATP2A2 FOXP3 IL5 MT-CO1 NKX2-1
4 immune system MP:0005387 10.26 ATP2A2 CD40LG CD79A FOXP3 HPGDS IL5
5 cardiovascular system MP:0005385 10.25 ANO1 ATP2A2 CD40LG FOXP3 MT-CO1 NKX2-1
6 digestive/alimentary MP:0005381 10.18 ATP2A2 FOXP3 IL5 NKX2-1 STAT1 TGFB1
7 mortality/aging MP:0010768 10.18 ANO1 ATP2A2 CD40LG FOXP3 HPGDS NKX2-1
8 integument MP:0010771 10.06 TNFRSF1B ANO1 ATP2A2 CD40LG FOXP3 HPGDS
9 nervous system MP:0003631 10.03 HPGDS NKX2-1 STAT1 TGFB1 TNFRSF1B TRIM33
10 neoplasm MP:0002006 10.02 TGFB1 TNFRSF1B TRIM33 WWOX ATP2A2 CD79A
11 liver/biliary system MP:0005370 9.98 CD79A FOXP3 IL5 STAT1 TGFB1 TNFRSF1B
12 muscle MP:0005369 9.91 ANO1 ATP2A2 MT-CO1 STAT1 TGFB1 TNFRSF1B
13 renal/urinary system MP:0005367 9.7 ANO1 ATP2A2 CD40LG CD79A FOXP3 TGFB1
14 respiratory system MP:0005388 9.5 ANO1 ATP2A2 FOXP3 IL5 NKX2-1 TGFB1
15 skeleton MP:0005390 9.28 ATP2A2 CD40LG NKX2-1 STAT1 TGFB1 TNFRSF1B

Drugs & Therapeutics for Norwegian Scabies

Drugs for Norwegian Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Vet_approved Phase 3 70288-86-7 6474909 46936176
2
Permethrin Approved, Investigational Phase 3 52645-53-1 40326
3 Anti-Infective Agents Phase 3
4 Antiparasitic Agents Phase 3
5 Dermatologic Agents Phase 3
6 Emollients Phase 3
7
Albendazole Approved, Vet_approved 54965-21-8 2082
8
Diethylcarbamazine Approved, Vet_approved 90-89-1 3052
9 Anthelmintics
10 Antimitotic Agents
11 Antiprotozoal Agents
12 Lipoxygenase Inhibitors
13 Liver Extracts

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies Not yet recruiting NCT02841215 Phase 3 Ivermectin 200 µg/kg;Ivermectin 400 µg/kg
2 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Recruiting NCT03177993 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA

Search NIH Clinical Center for Norwegian Scabies

Genetic Tests for Norwegian Scabies

Anatomical Context for Norwegian Scabies

MalaCards organs/tissues related to Norwegian Scabies:

39
Skin, T Cells, Liver, Testes, Bone, Monocytes, Brain

Publications for Norwegian Scabies

Articles related to Norwegian Scabies:

(show top 50) (show all 127)
id Title Authors Year
1
Norwegian scabies in a patient treated with Tripterygium glycoside for rheumatoid arthritis. ( 28954112 )
2017
2
Noodle pattern: a new dermoscopic pattern for crusted scabies (Norwegian scabies). ( 28758268 )
2017
3
Norwegian scabies - rare case of atypical manifestation. ( 28099611 )
2016
4
Large Nosocomial Outbreak Associated with a Norwegian Scabies Index Case Undergoing TNF-I+ Inhibitor Treatment: Management and Control. ( 26288185 )
2015
5
Norwegian scabies: Rare cause of erythroderma. ( 25657922 )
2015
6
Norwegian Scabies. ( 26265977 )
2015
7
Atypical presentation of crusted (Norwegian) scabies. ( 25819939 )
2015
8
Crusted (Norwegian) scabies: an under-recognized infestation characterized by an atypical presentation and delayed diagnosis. ( 25428862 )
2014
9
Norwegian scabies. ( 23958988 )
2013
10
Reflectance confocal microscopy for quantification of Sarcoptes scabiei in Norwegian scabies. ( 22621304 )
2013
11
Norwegian scabies. ( 23431220 )
2013
12
Norwegian scabies mimicking rupioid psoriasis. ( 23197214 )
2012
13
Crusted Norwegian scabies, an opportunistic infection, with tocilizumab in rheumatoid arthritis. ( 21441056 )
2011
14
Norwegian scabies in a malnourished young adult: a case report. ( 20539068 )
2010
15
Generalized scaling and redness in a 2-month-old boy. Crusted (Norwegian) scabies (CS). ( 21182645 )
2010
16
Norwegian scabies in a renal transplant patient. ( 20835323 )
2010
17
Crusted (Norwegian) scabies following systemic and topical corticosteroid therapy. ( 20052371 )
2010
18
Dermoscopy of Norwegian scabies in a patient with acquired immunodeficiency syndrome. ( 20520938 )
2010
19
Neonatal Norwegian scabies: three cooperating causes. ( 21886727 )
2009
20
Clinical images: Infestation by Norwegian scabies. ( 19620272 )
2009
21
Norwegian scabies in immunosuppressed patient misdiagnosed as an adverse drug reaction. ( 19750822 )
2009
22
Images in clinical practice. Norwegian scabies presenting as erythroderma. ( 19915245 )
2009
23
Human T-cell lymphotrophic virus tropical paraparesis, hyperhidrosis and Norwegian scabies. ( 19747336 )
2009
24
Norwegian scabies associated with herpes simplex infection in a renal transplant patient. ( 19300201 )
2009
25
Atypically distributed cutaneous lesions of Norwegian scabies in an HIV-positive man in South India: a case report. ( 18341688 )
2008
26
New insights into disease pathogenesis in crusted (Norwegian) scabies: the skin immune response in crusted scabies. ( 18422789 )
2008
27
Norwegian scabies in a renal transplant patient. ( 18855794 )
2008
28
Norwegian scabies in a healthy woman during oral cyclosporine therapy. ( 17337413 )
2007
29
Norwegian scabies of the legs in a patient with paraplegia. ( 17239091 )
2007
30
Norwegian scabies mimicking onychomycosis and scalp dermatitis in a child with IPEX syndrome. ( 17224384 )
2007
31
Crusted Norwegian scabies in an adult with Langerhans cell histiocytosis: mishaps leading to systemic chemotherapy. ( 17515513 )
2007
32
Unusual laboratory findings in a case of Norwegian scabies provided a clue to diagnosis. ( 15872307 )
2005
33
Norwegian scabies in Peru: the impact of human T cell lymphotropic virus type I infection. ( 15964976 )
2005
34
Norwegian scabies in the immunocompromised patient. ( 15547127 )
2004
35
Localised genital Norwegian scabies in an AIDS patient. ( 14755042 )
2004
36
Norwegian scabies in an elderly patient who died after treatment with gammaBHC. ( 12729329 )
2003
37
Crusted (Norwegian) scabies. ( 11932093 )
2002
38
Control of transmission of Norwegian scabies. ( 12026155 )
2002
39
Severe and Norwegian scabies are strongly associated with retroviral (HIV-1/HTLV-1) infection in Bahia, Brazil. ( 12045498 )
2002
40
Crusted (Norwegian) scabies in leprosy. ( 11326599 )
2001
41
Lesson of the week: Norwegian scabies misdiagnosed as an adverse drug reaction. ( 10617527 )
2000
42
Crusted (Norwegian) scabies in a patient with smoldering adult T-cell leukemia. ( 11092275 )
2000
43
Crusted (Norwegian) scabies in two old-age home residents. ( 11177168 )
2000
44
Dermacase. Crusted Norwegian scabies. ( 10386207 )
1999
45
Crusted (Norwegian) scabies in a patient with dystrophic epidermolysis bullosa. ( 10583180 )
1999
46
Crusted (Norwegian) scabies. A simple office test demystifies the 'great imitator'. ( 10335327 )
1999
47
Crusted (Norwegian) scabies induced by use of topical corticosteroids and treated successfully with ivermectin. ( 10393619 )
1999
48
Norwegian scabies in a patient with acquired immunodeficiency syndrome. ( 9812044 )
1998
49
Ivermectin for crusted Norwegian scabies induced by use of topical steroids. ( 9487205 )
1998
50
Norwegian scabies and a toxic shock syndrome toxin 1-producing strain of Staphylococcus aureus endocarditis in a patient with trisomy 21. ( 9770170 )
1998

Variations for Norwegian Scabies

Expression for Norwegian Scabies

Search GEO for disease gene expression data for Norwegian Scabies.

Pathways for Norwegian Scabies

GO Terms for Norwegian Scabies

Biological processes related to Norwegian Scabies according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.89 FOXP3 NKX2-1 TGFB1 TRIM33 TWIST1
2 negative regulation of immune response GO:0050777 9.54 FOXP3 TGFB1
3 cellular response to growth factor stimulus GO:0071363 9.54 TGFB1 TNFRSF1B TWIST1
4 positive regulation of transcription regulatory region DNA binding GO:2000679 9.51 TGFB1 TWIST1
5 negative regulation of interleukin-17 production GO:0032700 9.48 FOXP3 TGFB1
6 positive regulation of regulatory T cell differentiation GO:0045591 9.46 FOXP3 TGFB1
7 negative regulation of histone acetylation GO:0035067 9.43 FOXP3 TWIST1
8 extrinsic apoptotic signaling pathway GO:0097191 9.43 TGFB1 TNFRSF1B WWOX
9 macrophage derived foam cell differentiation GO:0010742 9.4 STAT1 TGFB1
10 negative regulation of skeletal muscle tissue development GO:0048642 9.32 TGFB1 TWIST1
11 regulation of regulatory T cell differentiation GO:0045589 9.22 TGFB1
12 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.17 FOXP3 NKX2-1 STAT1 TGFB1 TRIM33 TWIST1
13 tolerance induction to self antigen GO:0002513 9.16 FOXP3 TGFB1
14 regulatory T cell differentiation GO:0045066 8.96 FOXP3 TGFB1

Molecular functions related to Norwegian Scabies according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.5 CD79A FOXP3 GSTM1 HPGDS STAT1 TGFB1
2 core promoter binding GO:0001047 9.16 FOXP3 NKX2-1
3 enzyme binding GO:0019899 9.1 ATP2A2 GSTM1 NKX2-1 STAT1 TGFB1 WWOX
4 protein binding GO:0005515 10.16 ANO1 ATP2A2 CD40LG CD79A FOXP3 HPGDS

Sources for Norwegian Scabies

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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