MCID: NRW001
MIFTS: 42

Norwegian Scabies malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Norwegian Scabies

Aliases & Descriptions for Norwegian Scabies:

Name: Norwegian Scabies 12 50 14
Crusted Scabies 12 50 69
Seven Year Itch 50

Classifications:



External Ids:

Disease Ontology 12 DOID:14374
NCIt 47 C34855
UMLS 69 C0028425

Summaries for Norwegian Scabies

NIH Rare Diseases : 50 crusted scabies (also called norwegian scabies) is a severe form of scabies that most often occurs in people who have a weakened immune system or a neurological disease, the elderly, the disabled, or those who are mentally impaired. the condition is characterized by thick crusts of skin that contain large numbers of scabies mites and eggs. the usual features of scabies (itching and a rash) may be absent. crusted scabies is very contagious and can spread easily both by direct skin-to-skin contacts and through contaminated items such as clothing, bedding, and furniture. it is caused by superinfestation with sarcoptes scabiei var hominis, but why the crusted scabies develops is unknown.  people with crusted scabies should receive quick and aggressive medical treatment for their infestation to prevent outbreaks of scabies.ivermectin is commonly used for treatment.   last updated: 12/10/2016

MalaCards based summary : Norwegian Scabies, also known as crusted scabies, is related to rheumatoid arthritis and scabies. An important gene associated with Norwegian Scabies is FOXP3 (Forkhead Box P3), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. The drugs Ivermectin and Permethrin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are cellular and homeostasis/metabolism

Disease Ontology : 12 A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.

Related Diseases for Norwegian Scabies

Diseases related to Norwegian Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.1 CD40LG CD79A FOXP3 TGFB1 TNFRSF1B
2 scabies 10.8
3 immunoglobulin alpha deficiency 10.3 CD4 NT5C
4 prostate carcinoma in situ 10.3 CD4 CD40LG
5 alcoholic neuropathy 10.3 CD40LG CD79A
6 camptodactyly vertebral fusion 10.3 CD40LG CD79A
7 chronic duodenal ileus 10.3 CD4 CD40LG
8 spinal polio 10.3 CD40LG CD79A
9 rabies 10.3 CD40LG CD79A
10 unilateral retinoblastoma 10.3 CD40LG CD79A
11 mesangial proliferative glomerulonephritis 10.3 CD40LG CD79A
12 delta chain disease 10.3 CD40LG CD79A
13 rosacea conjunctivitis 10.3 CD4 CD79A FOXP3
14 discitis 10.3 CD40LG CD79A
15 spinal canal and spinal cord meningioma 10.3 CD40LG CD79A
16 trichostrongyloidiasis 10.2 CD40LG CD79A
17 cysticercosis 10.2 CD4 CD40LG
18 heart septal defect 10.2 CD40LG CD79A
19 cutaneous polyarteritis nodosa 10.2 CD40LG CD79A
20 mild pre-eclampsia 10.2 CD40LG CD79A
21 pediatric meningioma 10.2 CD40LG CD79A
22 tonsil cancer 10.2 CD40LG CD79A
23 indomethacin antenatal infection 10.2 CD40LG CD79A
24 pneumoconiosis due to talc 10.2 CD4 FOXP3
25 postcricoid region cancer 10.2 CD40LG CD79A
26 colloid adenoma 10.2 CD4 CD40LG CD79A
27 beach ear 10.2 CD40LG CD79A
28 atypical breast papilloma 10.2 CD4 CD40LG
29 lymphocytic gastritis 10.2 CD4 FOXP3 IL5
30 retinal microaneurysm 10.2 CD4 CD40LG CD79A
31 coronary artery dissection, spontaneous 10.2 ATP2A2 CD40LG CD79A
32 generalized atherosclerosis 10.2 CD4 CD40LG CD79A
33 bursitis 10.2 CD4 CD40LG CD79A
34 syphilis 10.2 CD4 CD40LG CD79A
35 acute kidney tubular necrosis 10.2 CD40LG CD79A
36 immunoglobulin beta deficiency 10.2 CD4 CD40LG CD79A
37 polyneuropathy due to drug 10.2 CD4 CD40LG CD79A
38 dysentery 10.2 CD4 CD40LG CD79A
39 uveitis 10.2 CD4 CD40LG CD79A
40 dysplastic nevus syndrome 10.2 CD4 CD40LG CD79A
41 abducens nerve disease 10.2 CD4 CD40LG CD79A
42 severe nonproliferative diabetic retinopathy 10.2 CD4 CD40LG CD79A
43 perinatal necrotizing enterocolitis 10.2 CD4 CD40LG CD79A
44 tularemia 10.2 CD4 CD40LG CD79A
45 gluten allergy 10.2 CD4 CD40LG CD79A
46 oral cavity cancer 10.2 CD4 CD40LG CD79A
47 autonomic peripheral neuropathy 10.2 CD4 CD40LG CD79A
48 wound botulism 10.2 CD4 CD40LG CD79A
49 atheroembolism of kidney 10.2 CD40LG CD79A
50 autoimmune disease of skin and connective tissue 10.2 CD4 CD40LG CD79A

Graphical network of the top 20 diseases related to Norwegian Scabies:



Diseases related to Norwegian Scabies

Symptoms & Phenotypes for Norwegian Scabies

MGI Mouse Phenotypes related to Norwegian Scabies:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 FOXP3 HPGDS MT-CO1 NKX2-1 TGFB1 TNFRSF1B
2 homeostasis/metabolism MP:0005376 10 ATP2A2 CD4 CD40LG CD79A FOXP3 HPGDS
3 digestive/alimentary MP:0005381 9.97 NKX2-1 TGFB1 TNFRSF1B TRIM33 TWIST1 ATP2A2
4 immune system MP:0005387 9.9 ATP2A2 CD4 CD40LG CD79A FOXP3 HPGDS
5 neoplasm MP:0002006 9.56 ATP2A2 CD79A HPGDS IL5 NKX2-1 TGFB1
6 nervous system MP:0003631 9.32 ATP2A2 CD4 CD40LG CD79A HPGDS NKX2-1

Drugs & Therapeutics for Norwegian Scabies

Drugs for Norwegian Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Vet_approved Phase 3 70288-86-7 6474909 46936176
2
Permethrin Approved, Investigational Phase 3 52645-53-1 40326
3 Dermatologic Agents Phase 3
4 Emollients Phase 3
5 Anti-Infective Agents Phase 3
6 Antiparasitic Agents Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies Not yet recruiting NCT02841215 Phase 3
2 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Not yet recruiting NCT03177993

Search NIH Clinical Center for Norwegian Scabies

Genetic Tests for Norwegian Scabies

Anatomical Context for Norwegian Scabies

MalaCards organs/tissues related to Norwegian Scabies:

39
Skin, T Cells, Testes, Monocytes, Bone, Colon, Brain

Publications for Norwegian Scabies

Articles related to Norwegian Scabies:

(show top 50) (show all 124)
id Title Authors Year
1
Norwegian scabies: Rare cause of erythroderma. ( 25657922 )
2015
2
Atypical presentation of crusted (Norwegian) scabies. ( 25819939 )
2015
3
Large Nosocomial Outbreak Associated with a Norwegian Scabies Index Case Undergoing TNF-I+ Inhibitor Treatment: Management and Control. ( 26288185 )
2015
4
Norwegian Scabies. ( 26265977 )
2015
5
Crusted (Norwegian) scabies: an under-recognized infestation characterized by an atypical presentation and delayed diagnosis. ( 25428862 )
2014
6
Norwegian scabies. ( 23958988 )
2013
7
Norwegian scabies. ( 23431220 )
2013
8
Reflectance confocal microscopy for quantification of Sarcoptes scabiei in Norwegian scabies. ( 22621304 )
2013
9
Norwegian scabies mimicking rupioid psoriasis. ( 23197214 )
2012
10
Crusted Norwegian scabies, an opportunistic infection, with tocilizumab in rheumatoid arthritis. ( 21441056 )
2011
11
Dermoscopy of Norwegian scabies in a patient with acquired immunodeficiency syndrome. ( 20520938 )
2010
12
Crusted (Norwegian) scabies following systemic and topical corticosteroid therapy. ( 20052371 )
2010
13
Norwegian scabies in a malnourished young adult: a case report. ( 20539068 )
2010
14
Generalized scaling and redness in a 2-month-old boy. Crusted (Norwegian) scabies (CS). ( 21182645 )
2010
15
Norwegian scabies in a renal transplant patient. ( 20835323 )
2010
16
Norwegian scabies in immunosuppressed patient misdiagnosed as an adverse drug reaction. ( 19750822 )
2009
17
Clinical images: Infestation by Norwegian scabies. ( 19620272 )
2009
18
Images in clinical practice. Norwegian scabies presenting as erythroderma. ( 19915245 )
2009
19
Human T-cell lymphotrophic virus tropical paraparesis, hyperhidrosis and Norwegian scabies. ( 19747336 )
2009
20
Norwegian scabies associated with herpes simplex infection in a renal transplant patient. ( 19300201 )
2009
21
Neonatal Norwegian scabies: three cooperating causes. ( 21886727 )
2009
22
Norwegian scabies in a renal transplant patient. ( 18855794 )
2008
23
Atypically distributed cutaneous lesions of Norwegian scabies in an HIV-positive man in South India: a case report. ( 18341688 )
2008
24
New insights into disease pathogenesis in crusted (Norwegian) scabies: the skin immune response in crusted scabies. ( 18422789 )
2008
25
Norwegian scabies of the legs in a patient with paraplegia. ( 17239091 )
2007
26
Norwegian scabies mimicking onychomycosis and scalp dermatitis in a child with IPEX syndrome. ( 17224384 )
2007
27
Norwegian scabies in a healthy woman during oral cyclosporine therapy. ( 17337413 )
2007
28
Crusted Norwegian scabies in an adult with Langerhans cell histiocytosis: mishaps leading to systemic chemotherapy. ( 17515513 )
2007
29
Unusual laboratory findings in a case of Norwegian scabies provided a clue to diagnosis. ( 15872307 )
2005
30
Norwegian scabies in Peru: the impact of human T cell lymphotropic virus type I infection. ( 15964976 )
2005
31
Norwegian scabies in the immunocompromised patient. ( 15547127 )
2004
32
Localised genital Norwegian scabies in an AIDS patient. ( 14755042 )
2004
33
Norwegian scabies in an elderly patient who died after treatment with gammaBHC. ( 12729329 )
2003
34
Crusted (Norwegian) scabies. ( 11932093 )
2002
35
Control of transmission of Norwegian scabies. ( 12026155 )
2002
36
Severe and Norwegian scabies are strongly associated with retroviral (HIV-1/HTLV-1) infection in Bahia, Brazil. ( 12045498 )
2002
37
Crusted (Norwegian) scabies in leprosy. ( 11326599 )
2001
38
Lesson of the week: Norwegian scabies misdiagnosed as an adverse drug reaction. ( 10617527 )
2000
39
Crusted (Norwegian) scabies in a patient with smoldering adult T-cell leukemia. ( 11092275 )
2000
40
Crusted (Norwegian) scabies in two old-age home residents. ( 11177168 )
2000
41
Crusted (Norwegian) scabies induced by use of topical corticosteroids and treated successfully with ivermectin. ( 10393619 )
1999
42
Dermacase. Crusted Norwegian scabies. ( 10386207 )
1999
43
Crusted (Norwegian) scabies. A simple office test demystifies the 'great imitator'. ( 10335327 )
1999
44
Crusted (Norwegian) scabies in a patient with dystrophic epidermolysis bullosa. ( 10583180 )
1999
45
Ivermectin for crusted Norwegian scabies induced by use of topical steroids. ( 9487205 )
1998
46
Norwegian scabies and a toxic shock syndrome toxin 1-producing strain of Staphylococcus aureus endocarditis in a patient with trisomy 21. ( 9770170 )
1998
47
Norwegian scabies in a patient with acquired immunodeficiency syndrome. ( 9812044 )
1998
48
Is crusted (Norwegian) scabies a marker of adult T cell leukemia/lymphoma in human T lymphotropic virus type I-seropositive patients? ( 9333174 )
1997
49
Norwegian scabies complicated by fatal brain abscess in a renal transplant patient. ( 8684551 )
1996
50
Successful treatment of crusted (Norwegian) scabies with ivermectin in two patients with human immunodeficiency virus infection. ( 8949458 )
1996

Variations for Norwegian Scabies

Expression for Norwegian Scabies

Search GEO for disease gene expression data for Norwegian Scabies.

Pathways for Norwegian Scabies

Pathways related to Norwegian Scabies according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.57 CD4 CD40LG FOXP3 IL5 TGFB1
2 12.29 CD40LG CD79A FOXP3 TNFRSF1B
3
Show member pathways
12.17 CD4 CD40LG IL5 TGFB1
4 11.77 CD4 CD79A IL5
5 11.74 TGFB1 TNFRSF1B TWIST1
6
Show member pathways
11.46 CD40LG FOXP3 IL5
7 11.22 CD4 FOXP3 IL5
8
Show member pathways
11.1 FOXP3 TGFB1 TNFRSF1B
9 11 CD4 CD40LG CD79A
10 10.85 CD40LG IL5 TNFRSF1B
11 10.77 CD40LG FOXP3 IL5 TGFB1
12 10.65 IL5 TGFB1
13 10.61 CD4 IL5 TGFB1

GO Terms for Norwegian Scabies

Cellular components related to Norwegian Scabies according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 8.92 CD4 CD79A KCNE1 TNFRSF1B

Biological processes related to Norwegian Scabies according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.91 CD4 FOXP3 IL5 NKX2-1 TGFB1
2 negative regulation of transcription, DNA-templated GO:0045892 9.83 FOXP3 NKX2-1 TGFB1 TRIM33 TWIST1
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.65 CD4 IL5 TGFB1
4 positive regulation of histone acetylation GO:0035066 9.54 FOXP3 TGFB1
5 positive regulation of transcription regulatory region DNA binding GO:2000679 9.52 TGFB1 TWIST1
6 cellular response to growth factor stimulus GO:0071363 9.5 TGFB1 TNFRSF1B TWIST1
7 negative regulation of immune response GO:0050777 9.49 FOXP3 TGFB1
8 negative regulation of interleukin-17 production GO:0032700 9.46 FOXP3 TGFB1
9 positive regulation of regulatory T cell differentiation GO:0045591 9.4 FOXP3 TGFB1
10 negative regulation of histone acetylation GO:0035067 9.37 FOXP3 TWIST1
11 T cell activation GO:0042110 9.33 CD4 FOXP3 TGFB1
12 negative regulation of skeletal muscle tissue development GO:0048642 9.26 TGFB1 TWIST1
13 tolerance induction to self antigen GO:0002513 8.96 FOXP3 TGFB1
14 regulatory T cell differentiation GO:0045066 8.62 FOXP3 TGFB1

Molecular functions related to Norwegian Scabies according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.35 ATP2A2 CD4 GSTM1 NKX2-1 TGFB1
2 protein homodimerization activity GO:0042803 9.17 CD4 CD79A FOXP3 GSTM1 HPGDS TGFB1

Sources for Norwegian Scabies

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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