MCID: NTR005
MIFTS: 46

Nutritional Deficiency Disease

Categories: Metabolic diseases, Immune diseases, Blood diseases

Aliases & Classifications for Nutritional Deficiency Disease

MalaCards integrated aliases for Nutritional Deficiency Disease:

Name: Nutritional Deficiency Disease 12 14
Malnutrition 69 28
Nutrition 40 3
Carbamoyl-Phosphate Synthase I Deficiency Disease 69
Nutritional Deficiency 51
Nutritional Disorder 51
Deficiency Diseases 69
Nutrition Disorders 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5113
MeSH 41 D003677

Summaries for Nutritional Deficiency Disease

MedlinePlus : 40 Food provides the energy and nutrients you need to be healthy. Nutrients include proteins, carbohydrates, fats, vitamins, minerals, and water. Healthy eating is not hard. The key is to Eat a variety of foods, including vegetables, fruits, and whole-grain products Eat lean meats, poultry, fish, beans, and low-fat dairy products Drink lots of water Limit salt, sugar, alcohol, saturated fat, and trans fat in your diet Saturated fats are usually fats that come from animals. Look for trans fat on the labels of processed foods, margarines, and shortenings. Centers for Disease Control and Prevention

MalaCards based summary : Nutritional Deficiency Disease, also known as malnutrition, is related to protein-energy malnutrition and kwashiorkor, and has symptoms including abdominal symptom, decrease in appetite and nausea and vomiting. An important gene associated with Nutritional Deficiency Disease is TF (Transferrin), and among its related pathways/superpathways are Selenium Micronutrient Network and Senescence and Autophagy in Cancer. Affiliated tissues include skin, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 72 Malnutrition is a condition that results from eating a diet in which nutrients are either not enough or... more...

Related Diseases for Nutritional Deficiency Disease

Diseases related to Nutritional Deficiency Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 protein-energy malnutrition 33.7 ALB IGF1 IL6 LEP TF TTR
2 kwashiorkor 33.1 ALB TF TTR
3 marasmus 32.9 ALB IGFBP3 TF TTR
4 insulin-like growth factor i 31.4 BGLAP IGF1 IGFBP1 IGFBP3 LEP
5 nutritional optic neuropathy 12.1
6 rickets 11.5
7 subacute cerebellar degeneration 11.4
8 cystic fibrosis 11.4
9 congenital short bowel syndrome 11.3
10 phenylketonuria 11.2
11 glossitis 11.1
12 biotin deficiency 10.9
13 esophageal cancer 10.8
14 peripheral nervous system disease 10.8
15 paramyloidosis 10.6 ALB TTR
16 slipped capital femoral epiphysis 10.5 IGF1 IGFBP3
17 cold agglutinin disease 10.5 CRP IL6
18 vibrio vulnificus infection 10.5 EPO IL6
19 testicular yolk sac tumor 10.5 ALB TF TTR
20 secondary adrenal insufficiency 10.5 IGF1 IGFBP3
21 decubitus ulcer 10.5 ALB CRP TTR
22 pure red-cell aplasia 10.4 ALB EPO TF
23 obesity-hypoventilation syndrome 10.4 IL6 LEP
24 tropical sprue 10.4 ALB GIF
25 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.4 IGF1 IGFBP3
26 fetal macrosomia 10.4 IGF1 IGFBP3 LEP
27 ariboflavinosis 10.4 ALB MTHFR TF
28 obstructive jaundice 10.4 ALB IL6 TTR
29 hypersensitivity reaction type iii disease 10.4 ALB CRP IL6
30 acute cystitis 10.4 ALB CRP IL6
31 osteoporotic fracture 10.4 IL6 MTHFR
32 acute pyelonephritis 10.4 ALB CRP IL6
33 hemorrhagic fever with renal syndrome 10.4 ALB CRP IL6
34 diabetic foot ulcers 10.4 CRP IL6
35 intermittent claudication 10.4 ALB CRP IL6
36 apnea, obstructive sleep 10.4 CRP IL6 LEP
37 cryopyrin-associated periodic syndrome 10.4 CRP IL6
38 pyelonephritis 10.4 ALB CRP IL6
39 typhoid fever 10.4 ALB CRP IL6
40 appendicitis 10.4 ALB CRP IL6
41 sleep disorder 10.4 CRP IL6 LEP
42 coronary stenosis 10.4 ALB CRP IL6
43 neutrophilia, hereditary 10.4 CRP IL6
44 bulimia nervosa 2 10.4 GHRL IGF1 LEP
45 growth hormone deficiency 10.4 GHRL IGF1 IGFBP3
46 bacterial meningitis 10.4 ALB CRP IL6
47 trypanosomiasis 10.4 ALB IL6 TF
48 endocarditis 10.4 ALB CRP IL6
49 gastroenteritis 10.4 ALB CRP IL6
50 hypogonadism, male 10.4 BGLAP LEP

Comorbidity relations with Nutritional Deficiency Disease via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Iron Deficiency Anemia
Osteoporosis Protein-Energy Malnutrition
Schizophreniform Disorder Swallowing Disorders

Graphical network of the top 20 diseases related to Nutritional Deficiency Disease:



Diseases related to Nutritional Deficiency Disease

Symptoms & Phenotypes for Nutritional Deficiency Disease

UMLS symptoms related to Nutritional Deficiency Disease:


abdominal symptom, decrease in appetite, nausea and vomiting, diarrhea, constipation, cachexia, abdominal pain

MGI Mouse Phenotypes related to Nutritional Deficiency Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 ALB CRP EPO GHRL GIF IGF1
2 liver/biliary system MP:0005370 9.17 ALB EPO GIF IGFBP1 IGFBP3 IL6

Drugs & Therapeutics for Nutritional Deficiency Disease

Genetic Tests for Nutritional Deficiency Disease

Genetic tests related to Nutritional Deficiency Disease:

# Genetic test Affiliating Genes
1 Malnutrition 28

Anatomical Context for Nutritional Deficiency Disease

MalaCards organs/tissues related to Nutritional Deficiency Disease:

38
Skin

Publications for Nutritional Deficiency Disease

Articles related to Nutritional Deficiency Disease:

# Title Authors Year
1
Skin manifestations of nutritional deficiency disease in children: modern day contexts. ( 23171006 )
2012
2
Principles underlying the early diagnosis of nutritional deficiency disease. ( 21016693 )
1946

Variations for Nutritional Deficiency Disease

Expression for Nutritional Deficiency Disease

Search GEO for disease gene expression data for Nutritional Deficiency Disease.

Pathways for Nutritional Deficiency Disease

GO Terms for Nutritional Deficiency Disease

Cellular components related to Nutritional Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 ALB BGLAP CRP EPO GHRL GIF
2 endoplasmic reticulum lumen GO:0005788 9.7 ALB BGLAP GHRL IGFBP1 IGFBP3 IL6
3 extracellular space GO:0005615 9.47 ALB BGLAP CRP EPO GHRL GIF
4 insulin-like growth factor ternary complex GO:0042567 9.32 IGF1 IGFBP3
5 insulin-like growth factor binding protein complex GO:0016942 9.26 IGF1 IGFBP3

Biological processes related to Nutritional Deficiency Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.87 ALB EPO GHRL IGF1 IL6 LEP
2 post-translational protein modification GO:0043687 9.85 ALB IGFBP1 IGFBP3 IL6 TF
3 aging GO:0007568 9.81 BGLAP EPO HAMP IGFBP1
4 cholesterol metabolic process GO:0008203 9.74 LEP MVK PMVK
5 response to estrogen GO:0043627 9.72 BGLAP EPO GHRL
6 positive regulation of MAPK cascade GO:0043410 9.71 IGF1 IGFBP3 IL6 LEP
7 response to nutrient levels GO:0031667 9.7 BGLAP GHRL LEP
8 regulation of receptor activity GO:0010469 9.7 EPO GHRL HAMP IGF1 IL6 LEP
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 EPO IGF1 IL6 LEP
10 isoprenoid biosynthetic process GO:0008299 9.59 MVK PMVK
11 positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 9.58 HAMP IGF1
12 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.58 IGF1 IGFBP3
13 adult feeding behavior GO:0008343 9.56 GHRL LEP
14 regulation of insulin-like growth factor receptor signaling pathway GO:0043567 9.54 IGFBP1 IGFBP3
15 positive regulation of STAT protein import into nucleus GO:2000366 9.49 IL6 LEP
16 bone mineralization involved in bone maturation GO:0035630 9.48 IGF1 LEP
17 isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287 9.43 MVK PMVK
18 negative regulation of lipid storage GO:0010888 9.43 CRP IL6 LEP
19 acute-phase response GO:0006953 9.26 CRP EPO HAMP IL6
20 cellular protein metabolic process GO:0044267 9.17 ALB IGF1 IGFBP1 IGFBP3 IL6 TF

Molecular functions related to Nutritional Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor I binding GO:0031994 9.16 IGFBP1 IGFBP3
2 hormone activity GO:0005179 9.1 EPO GHRL HAMP IGF1 LEP TTR
3 insulin-like growth factor II binding GO:0031995 8.96 IGFBP1 IGFBP3

Sources for Nutritional Deficiency Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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