MCID: NTR005
MIFTS: 47

Nutritional Deficiency Disease

Categories: Immune diseases, Blood diseases, Metabolic diseases

Aliases & Classifications for Nutritional Deficiency Disease

MalaCards integrated aliases for Nutritional Deficiency Disease:

Name: Nutritional Deficiency Disease 12 14
Nutrition 41 3
Carbamoyl-Phosphate Synthase I Deficiency Disease 69
Nutritional Deficiency 52
Nutritional Disorder 52
Deficiency Diseases 69
Nutrition Disorders 69
Malnutrition 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5113
MeSH 42 D003677
UMLS 69 C0011156

Summaries for Nutritional Deficiency Disease

MedlinePlus : 41 food provides the energy and nutrients you need to be healthy. nutrients include proteins, carbohydrates, fats, vitamins, minerals, and water. healthy eating is not hard. the key is to eat a variety of foods, including vegetables, fruits, and whole-grain products eat lean meats, poultry, fish, beans, and low-fat dairy products drink lots of water limit salt, sugar, alcohol, saturated fat, and trans fat in your diet saturated fats are usually fats that come from animals. look for trans fat on the labels of processed foods, margarines, and shortenings. centers for disease control and prevention

MalaCards based summary : Nutritional Deficiency Disease, also known as nutrition, is related to nutritional optic neuropathy and marasmus, and has symptoms including abdominal pain, cachexia and constipation. An important gene associated with Nutritional Deficiency Disease is TF (Transferrin), and among its related pathways/superpathways are HIF-1 signaling pathway and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Benzocaine and Iron have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Nutritional Deficiency Disease

Diseases related to Nutritional Deficiency Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
id Related Disease Score Top Affiliating Genes
1 nutritional optic neuropathy 12.0
2 marasmus 11.4
3 kwashiorkor 11.4
4 rickets 11.4
5 subacute cerebellar degeneration 11.3
6 cystic fibrosis 11.3
7 insulin-like growth factor i 11.3
8 congenital short bowel syndrome 11.2
9 phenylketonuria 11.1
10 glossitis 11.0
11 midface dysplasia 10.9 ALB TTR
12 early-onset severe reducing body myopathy, x-linked 10.9 ALB TTR
13 pancreatic steatorrhea 10.8 ALB GIF
14 biotin deficiency 10.8
15 lambert-eaton myasthenic syndrome 10.8 F2 TF
16 non-hodgkin lymphoma, during pregnancy 10.7 ALB F2
17 esophageal cancer 10.7
18 dementia 10.7
19 alcoholic neuropathy 10.7
20 atrophic rhinitis 10.7
21 peripheral nervous system disease 10.7
22 marchiafava bignami disease 10.7
23 sleep disorder 10.7 ALB TF TTR
24 pellagra 10.7 ALB MTHFR TF
25 bacteriuria 10.7 TF TTR
26 syncope 10.6 F2 MTHFR
27 fragile x syndrome type 2 10.6 ALB F2
28 porphyria 10.6 F2 MTHFR
29 lockwood feingold syndrome 10.6 F2 MTHFR
30 superior limbic keratoconjunctivitis 10.6 F2 MTHFR
31 perinatal necrotizing enterocolitis 10.6 ALB GHRL LEP
32 tinf2-related dyskeratosis congenita 10.6 HAMP TF TFRC
33 cataract 10.5 ALB TTR
34 cerebral sarcoidosis 10.5 ALB EPO TF
35 oral cavity carcinoma in situ 10.5 ALB F2
36 paranasal sinus sarcoma 10.5 ALB F2 TTR
37 alpha 1-antitrypsin deficiency 10.5 ALB F2 TF
38 bladder sarcoma 10.5 ALB LEP TF TTR
39 follicular adenoma 10.5 F2 MTHFR
40 capillary hemangioma 10.5 ALB F2 MTHFR
41 aryepiglottic fold cancer 10.5 ALB F2 MTHFR
42 spinocerebellar ataxia 8 10.5 ALB F2 TF
43 endometrial adenocarcinoma 10.5 EPO HAMP TF
44 obstructive jaundice 10.4 ALB F2 MTHFR
45 timothy syndrome type 2 10.4 EPO TF TFRC
46 male genital organ stricture 10.4 ALB IGFBP3 TF TTR
47 conjunctival vascular disease 10.4 ALB EPO TFRC
48 female infertility of uterine origin 10.4 ALB F2 TF TTR
49 sickle cell anemia 10.4 EPO TF TFRC
50 chronic inflammatory demyelinating polyneuritis 10.4 ALB EPO F2

Comorbidity relations with Nutritional Deficiency Disease via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Iron Deficiency Anemia
Osteoporosis Protein-Energy Malnutrition
Schizophreniform Disorder Swallowing Disorders

Graphical network of the top 20 diseases related to Nutritional Deficiency Disease:



Diseases related to Nutritional Deficiency Disease

Symptoms & Phenotypes for Nutritional Deficiency Disease

UMLS symptoms related to Nutritional Deficiency Disease:


abdominal pain, cachexia, constipation, diarrhea, nausea and vomiting, abdominal symptom

MGI Mouse Phenotypes related to Nutritional Deficiency Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 TMPRSS6 TTR ALB CRP EPO F2
2 cardiovascular system MP:0005385 9.86 CRP EPO F2 HFE2 LEP MGP
3 integument MP:0010771 9.56 EPO F2 HFE2 IGFBP3 LEP MTHFR
4 liver/biliary system MP:0005370 9.17 ALB EPO HFE2 IGFBP3 LEP TFRC

Drugs & Therapeutics for Nutritional Deficiency Disease

Drugs for Nutritional Deficiency Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 827)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
2
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1 7439-89-6 23925
3
Albendazole Approved, Vet_approved Phase 4,Phase 3 54965-21-8 2082
4
Calcium Carbonate Approved Phase 4,Phase 3,Phase 2 471-34-1
5
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6 32051 23994
6
Copper Approved Phase 4,Phase 2 7440-50-8 27099
7
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3 13422-51-0 11953898 5460373 44475014
8
Selenium Approved, Vet_approved Phase 4,Phase 3,Phase 2 7782-49-2
9
Rabeprazole Approved, Investigational Phase 4,Phase 1 117976-89-3 5029
10
Ceftriaxone Approved Phase 4,Phase 3,Phase 2 73384-59-5 5479530 5361919
11
Rilpivirine Approved Phase 4,Phase 1 500287-72-9
12
Lamotrigine Approved, Investigational Phase 4,Phase 1 84057-84-1 3878
13
Morphine Approved, Investigational Phase 4,Phase 1 57-27-2 5288826
14
Mebendazole Approved, Vet_approved Phase 4,Phase 2,Phase 1 31431-39-7 4030
15
Piperazine Approved, Vet_approved Phase 4,Phase 1 110-85-0 4837
16
Nifedipine Approved Phase 4,Phase 1 21829-25-4 4485
17 Pyrantel Approved, Vet_approved Phase 4
18
Gabapentin Approved, Investigational Phase 4,Phase 1 60142-96-3 3446
19
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 1 148553-50-8 5486971
20
Loperamide Approved Phase 4 53179-11-6 3955
21
Glycerol Approved, Investigational Phase 4 56-81-5 753
22
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
23
Lopinavir Approved Phase 4 192725-17-0 92727
24
Ritonavir Approved, Investigational Phase 4,Phase 1 155213-67-5 392622
25
Zidovudine Approved Phase 4 30516-87-1 35370
26
Sorbitol Approved Phase 4,Phase 1 50-70-4 5780
27
Chromium Approved Phase 4 7440-47-3 27668
28
Molybdenum Approved Phase 4 7439-98-7 185498
29
Nicotine Approved Phase 4 54-11-5 942 89594
30
Thrombin Approved Phase 4
31
Tranexamic Acid Approved Phase 4 1197-18-8 5526
32
Dopamine Approved Phase 4,Phase 1,Phase 2 51-61-6, 62-31-7 681
33
Itraconazole Approved, Investigational Phase 4,Phase 1 84625-61-6 55283
34
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
35 Zinc sulfate Approved Phase 4,Phase 2,Phase 3 7733-02-0
36
Amodiaquine Approved Phase 4,Phase 1 86-42-0 2165
37
Artesunate Approved Phase 4,Phase 1 88495-63-0 6917864 5464098
38
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
39
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
40
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 67-97-0 6221 10883523 5280795
41
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-14-6 5280793
42 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 1
43
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 11103-57-4, 68-26-8 445354
44
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1406-16-2
45 Tocopherol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
46
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-02-9 14985
47
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
48
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 2,Phase 3 68-19-9 44176380
49
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
50
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 59-67-6 938

Interventional clinical trials:

(show top 50) (show all 1714)

id Name Status NCT ID Phase Drugs
1 Effects of Nutritional Supplementation in Malnourished Patients in Stable COPD Unknown status NCT02197871 Phase 4
2 Optimizing Treatment Programs for Chronic Kidney Disease-mineral and Bone Disorder and Malnutrition Unknown status NCT02005302 Phase 4 1,25(OH)2 Vitamin D3;Vitamin D2
3 Enteral Nutrition After Cardiovascular Surgery Unknown status NCT01432769 Phase 4
4 Egg Albumin-Based Protein Supplement Versus Renal-specific Supplement in Hemodialysis Patients Unknown status NCT01981083 Phase 4
5 Vitamin D and Inflammatory Markers of Cardiovascular Disease in African Americans With Type 2 Diabetes Unknown status NCT01153243 Phase 4 Ergocalciferol;Placebo pill
6 Nutritional Supplementation in Patients With no Signs of Malnutrition Unknown status NCT01894828 Phase 4
7 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
8 Trial of Continuous Versus Interrupted Feeding for Intubated Intensive Care Unit Patients Unknown status NCT01383980 Phase 4
9 Bioequivalence Study of Raperazole 20mg DR Tabs and PARIET® 20 mg DR Tabs Under Fed Conditions Completed NCT02605395 Phase 4 IDIAZOLE 20mg DR tabs;PARIET 20 mg DR tabs
10 Nutritional Supplementation in Adults With Chronic Respiratory Disease Completed NCT02102009 Phase 4
11 Trial in Childhood Pneumonia With Malnutrition Completed NCT00968370 Phase 4
12 Effectiveness of a Ready-to-Use-Food (RUF) Supplement to Prevent Acute Child Malnutrition Completed NCT01154595 Phase 4
13 A Single-Dose Pharmacokinetics and Safety Study of TMC278 in Healthy Adult Japanese Participants Completed NCT01804244 Phase 4 TMC278
14 A Bioavailability Crossover Study of Two Formulations of Lamotrigine Extended Release Tablets in Healthy Subjects Completed NCT02821338 Phase 4 Lamotrigine Extended Release
15 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
16 Comparative Study to Evaluate KADIAN and Avinza in Healthy Adults Completed NCT00782548 Phase 4 morphine sulfate sustained-release capsules
17 The Effect of a Deworming Intervention to Improve Early Childhood Growth and Development in Resource-poor Areas Completed NCT01314937 Phase 4 Mebendazole
18 Influence of an Oral Nutritional Supplement Rich in Omega-3 Fatty Acids on Functional State and Quality of Life in Malnourished Patients With Gastroenterological Tumors Completed NCT00168987 Phase 4 oral nutritional supplement rich in eicosapentanoic acid
19 Postpartum Deworming: Improving Breastfeeding and Optimizing Infant Growth Completed NCT01748929 Phase 4 Albendazole;Placebo
20 Inactivated Influenza Vaccine Effectiveness in Tropical Africa Completed NCT00893906 Phase 4
21 The Effect of Neutral Peritoneal Dialysis (PD) Solution With Minimal Glucose-Degradation-Product (GDP) on Fluid Status and Body Composition Completed NCT00966615 Phase 4
22 Role of Calcium And Vitamin D In Nutritional Rickets And It's Management Completed NCT01578434 Phase 4 Vitamin D;Calcium Carbonate;Vitamin D and Calcium
23 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
24 Enteral Nutrition in Liver Cirrhosis Completed NCT00168961 Phase 4
25 A Study of Risk Factors for Anti-erythropoietin Antibody Positive Pure Red Cell Aplasia Among Patients With Chronic Kidney Disease Receiving Epoetin Alfa Completed NCT00211068 Phase 4 No intervention
26 Nitrogen Balance in Infants After Post Cardiothoracic Surgery Completed NCT01368705 Phase 4
27 Near Infrared Spectroscopy (NIRS) and Superior Mesenteric Artery (SMA) Doppler Patterns as Predictor of Feeding Tolerance in Very Low Birth Weight (VLBW) IntraUterine Growth Restricted (IUGR) and NON IUGR Infants Completed NCT01341236 Phase 4
28 Feeding the Patient at Nutritional Risk: Does the Clinical Outcome Improve? Completed NCT00440453 Phase 4
29 Vitamin D and Genetics in Nutritional Rickets Completed NCT00949832 Phase 4
30 Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study Completed NCT00228254 Phase 4 Zinc (12.5 mg/day);vitamin A 10,000 IU per week
31 Effects of Adalat LA and Coracten on Drug Levels, Blood Pressure, and Heart Rate in Fed Patients With Hypertension Completed NCT00672113 Phase 4 Adalat (Nifedipine, BAYA1040);Coracten
32 The Efficacy of Five Anthelmintic Regimes Against Trichuris Trichiura Infections in Schoolchildren in Jimma, Ethiopia Completed NCT01327469 Phase 4 Albendazole, 2 x 400mg;Albendazole 400mg;Mebendazole 500mg;Mebendazole 2 x 500mg;Pyrantel-oxantel + mebendazole
33 Influence of Vitamin D Treatment on Multi-systemic Functions in Young Men With Vitamin D Deficiency Due to Work Conditions Completed NCT01016184 Phase 4
34 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
35 Non Randomized Controlled Intervention Study Comparing Two Interventions of Nutritional Supplement on Malnutrition, Health and Mortality Completed NCT02085044 Phase 4
36 The Effect of Ophiocephalus Striatus Extract on Levels of IGF-1, Albumin, and MNA Score in Elderly With Malnutrition Completed NCT03065595 Phase 4
37 Vitamin D, Chronic Kidney Disease (CKD) and the Microcirculation Completed NCT00882401 Phase 4 Ergocalciferol (Vitamin D);Placebo
38 DaVita Assessment of Nutritional Supplement Effects (DANSE) Completed NCT00895401 Phase 4
39 How Does Magnesium Status Influence Calcium Homeostasis? Completed NCT01593501 Phase 4
40 Nutritional Intervention in Malnourished Elderly Patients Completed NCT00417508 Phase 4
41 Intradialytic Parenteral Nutrition in Hemodialysis Patients Completed NCT00501956 Phase 4 Intradialytic Parenteral Nutrition (IDPN)
42 Malnutrition in Gastroenterology Patients Completed NCT00168935 Phase 4 Fresubin protein energy Drink (CAVE! nutritional intervention)
43 Safety and Efficacy of Cerezyme® Infusions Every 4 Weeks Versus Every 2 Weeks in Type 1 Gaucher Disease Completed NCT00364858 Phase 4 Cerezyme
44 Effects of Glutamine on Gastric Emptying Completed NCT00943020 Phase 4
45 Vitamin D and Coronary Calcification Study Completed NCT00752102 Phase 4 Calcitriol (Rocaltrol®);Paricalcitol
46 Simulated Driving Performance, Daytime Sedation and Cognition in Healthy Volunteers Taking Gralise, Neurontin or Lyrica Completed NCT03179345 Phase 4 Gabapentin;Pregabalin
47 INEC Study: Immuno-modulating Enteral Nutrition in Cancer Completed NCT00333099 Phase 4
48 Vitamin D in Pediatric Crohn's Disease Completed NCT01187459 Phase 4
49 Vitamin D Deficiency in Chronic Kidney Disease (CKD) Patients Completed NCT00958451 Phase 4 Paricalcitol;Ergocalciferol
50 Efficacy of Vitamin D2 to Treat Chronic Kidney Disease Mineral and Bone Disorder Completed NCT01633853 Phase 4 Vitamin D2;1,25(OH)2 Vit D3

Search NIH Clinical Center for Nutritional Deficiency Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Nutritional Deficiency Disease

Anatomical Context for Nutritional Deficiency Disease

MalaCards organs/tissues related to Nutritional Deficiency Disease:

39
Kidney, Liver, Bone, Testes, Heart, Breast, Brain

Publications for Nutritional Deficiency Disease

Articles related to Nutritional Deficiency Disease:

id Title Authors Year
1
Skin manifestations of nutritional deficiency disease in children: modern day contexts. ( 23171006 )
2012
2
Principles underlying the early diagnosis of nutritional deficiency disease. ( 21016693 )
1946

Variations for Nutritional Deficiency Disease

Expression for Nutritional Deficiency Disease

Search GEO for disease gene expression data for Nutritional Deficiency Disease.

Pathways for Nutritional Deficiency Disease

GO Terms for Nutritional Deficiency Disease

Cellular components related to Nutritional Deficiency Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 ALB BGLAP CRP EPO F2 GHRL
2 endoplasmic reticulum lumen GO:0005788 9.73 ALB BGLAP F2 GHRL IGFBP3 TF
3 blood microparticle GO:0072562 9.62 ALB F2 TF TFRC
4 extracellular space GO:0005615 9.5 ALB BGLAP CRP EPO F2 GHRL
5 HFE-transferrin receptor complex GO:1990712 9.33 HFE2 TF TFRC

Biological processes related to Nutritional Deficiency Disease according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.65 BGLAP HAMP LEP
2 cellular protein metabolic process GO:0044267 9.55 ALB F2 IGFBP3 TF TTR
3 response to estrogen GO:0043627 9.54 BGLAP EPO GHRL
4 response to vitamin A GO:0033189 9.49 EPO HAMP
5 peptidyl-glutamic acid carboxylation GO:0017187 9.46 BGLAP F2
6 adult feeding behavior GO:0008343 9.43 GHRL LEP
7 iron ion homeostasis GO:0055072 9.43 HFE2 TF TMPRSS6
8 negative regulation of lipid storage GO:0010888 9.4 CRP LEP
9 response to nutrient levels GO:0031667 9.32 BGLAP LEP
10 acute-phase response GO:0006953 9.26 CRP EPO F2 HAMP
11 cellular iron ion homeostasis GO:0006879 9.02 HAMP HFE2 TF TFRC TMPRSS6

Molecular functions related to Nutritional Deficiency Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transferrin receptor binding GO:1990459 9.16 HFE2 TF
2 hormone activity GO:0005179 9.1 EPO GHRL HAMP LEP TG TTR
3 structural constituent of bone GO:0008147 8.96 BGLAP MGP

Sources for Nutritional Deficiency Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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