MCID: OBS005
MIFTS: 91

Obesity malady

Genetic diseases, Rare diseases, Metabolic diseases categories
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Summaries for Obesity

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MedlinePlus:33 Obesity means having too much body fat. it is different from being overweight, which means weighing too much. the weight may come from muscle, bone, fat, and/or body water. both terms mean that a person's weight is greater than what's considered healthy for his or her height. obesity occurs over time when you eat more calories than you use. the balance between calories-in and calories-out differs for each person. factors that might affect your weight include your genetic makeup, overeating, eating high-fat foods, and not being physically active. being obese increases your risk of diabetes, heart disease, stroke, arthritis, and some cancers. if you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases. for example, that means losing 10 to 20 pounds if you weigh 200 pounds. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Obesity is related to insulin resistance and morbid obesity. An important gene associated with Obesity is PYY (peptide YY), and among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. The drugs benzphetamine and phenylpropanolamine hydrochloride and the compounds glucose and lipid have been mentioned in the context of this disorder. Affiliated tissues include liver, ovary and heart, and related mouse phenotypes are homeostasis/metabolism and adipose tissue.

Wikipedia:65 Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a... more...

Descriptions from OMIM:46 601665,607514

Aliases & Classifications for Obesity

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Obesity, Aliases & Descriptions:

Name: Obesity 30 8 42 20 22 46 44 33 62


Classifications:



External Ids:

Disease Ontology8 DOID:9970
MeSH34 D009765
ICD9CM27 278.00
OMIM46 601665
NCIt39 C3283

Related Diseases for Obesity

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Diseases in the Obesity family:

Obesity, Mc4r-Related Obesity, Pparg-Related
Obesity, Susceptibility to, Cartpt-Related Obesity, Susceptibility to, Mc3r-Related
Obesity, Ucp3-Related Obesity, Pyy-Related
Obesity, Sim1-Related Obesity, Early-Onset
Obesity, Late-Onset

Diseases related to Obesity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 741)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance33.0PPARG, PYY, LEPR, LEP, MC3R, MC4R
2morbid obesity32.9PYY, LEPR, LEP, MC3R, MC4R, FTO
3hypertension32.6PPARG, POMC, ADRB3, ADRB2, LEP
4polycystic ovary syndrome32.5LEPR, PPARG, LEP, POMC, ADRB3, GHRL
5diabetes mellitus32.4ENPP1, GAD1, UCP1, UCP3, GHRL, FTO
6fatty liver disease32.2PPARG, LEPR, LEP, ADRB3
7glucose intolerance32.2GHRL, LEPR, ENPP1, ADRB3, LEP, PPARG
8type 2 diabetes mellitus32.1PPARG, ENPP1, UCP1, UCP3, GHRL, PYY
9eating disorder32.1PYY, GHRL, LEP
10atherosclerosis32.1LEP, ADRB2, ADRB3, ENPP1, UCP1, UCP3
11prader-willi syndrome32.0GHRL, LEP, LEPR, PYY
12hyperandrogenism32.0LEP, POMC, MC4R, PPARG
13anorexia nervosa31.9GHRL, POMC, PYY, MC4R, LEPR, MC3R
14hyperinsulinism31.8MC4R, PPARG, LEPR, LEP, GHRL
15hypogonadism31.8LEP, GHRL, POMC
16hypertriglyceridemia31.8ADRB3, LEP, PPARG
17breast cancer31.7GAD1, PPARG, LEPR, ENPP1, PYY, LEP
18gestational diabetes31.7LEPR, LEP, GAD1, ADRB3, ENPP1
19essential hypertension31.7LEPR, ADRB3, ADRB2, LEP
20hyperglycemia31.6LEPR, PPARG, ADRB3, LEP, POMC, GHRL
21bulimia nervosa31.6GHRL, PYY, MC4R, LEP, LEPR
22cushing's syndrome31.6LEP, POMC, GHRL
23lipodystrophy31.5LEP, PPARG, CARTPT, ADRB3
24metabolic syndrome x31.4LEP, PPARG
25arthritis31.4POMC, GHRL, ADRB2, LEP
26growth hormone deficiency31.4GHRL, POMC, LEP
27hypopituitarism31.3GHRL, LEP, POMC
28hypothyroidism31.3GHRL, LEP
29type 1 diabetes mellitus31.3UCP1, ADRB2, ADRB3, LEP, LEPR, GAD1
30adenoma31.2LEPR, PYY, PPARG, POMC, GHRL
31pre-eclampsia31.1ADRB2, LEP, LEPR, ADRB3
32diabetic nephropathy31.1PPARG, ADRB3, ENPP1, UCP1
33hypoglycemia31.0POMC, ADRB2, GHRL, GAD1
34insulinoma31.0GAD1, LEPR, GHRL, UCP1
35anovulation31.0GHRL, LEP
36familial partial lipodystrophy30.9PPARG, LEP
37precocious puberty30.9POMC, LEP
38chronic obstructive pulmonary disease30.9UCP3, LEPR, ADRB2
39multiple sclerosis30.7PPARG, POMC, ADRB2, GAD1
40amenorrhea30.7LEP, POMC
41acromegaly30.7LEP, GHRL, POMC, LEPR
42pheochromocytoma30.6PYY, ADRB2, UCP1, POMC
43adrenal gland hyperfunction30.6LEP, GHRL, POMC
44acth deficiency30.5POMC, MC4R
45liver disease10.8
46hepatitis10.8
47pituitary adenoma10.7GHRL, POMC, LEP, LEPR, PPARG
48pituitary tumors10.7PPARG, GHRL, POMC, LEPR
49familial hyperlipidemia10.7UCP1, LEP, ADRB3, PPARG, UCP3
50non-suppurative otitis media10.7MC4R, GHRL, LEP

Graphical network of the top 20 diseases related to Obesity:



Diseases related to obesity

Symptoms for Obesity

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Clinical features from OMIM:

601665,607514

Drugs & Therapeutics for Obesity

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Genetic Tests for Obesity

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Genetic tests related to Obesity:

id Genetic test Affiliating Genes
1 Obesity20 22

Anatomical Context for Obesity

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MalaCards organs/tissues related to Obesity:

32
Liver, Ovary, Heart, Adipocyte, Skeletal muscle, Bone, Kidney, Endothelial, Breast, Testes, Thyroid, Brain, Prostate, Pituitary, Monocytes, T cells, Colon, Skin, Lung, Hypothalamus, B cells, Pancreatic islet, Pancreas, Spinal cord, Myeloid, Neutrophil, Salivary gland, Bone marrow, Lymph node, Smooth muscle, Small intestine, Placenta, Testis, Amygdala, Eye, Whole blood, Spleen, Thymus, Cortex, Cerebellum, Retina, Nk cells, Pons, Tongue, Adrenal cortex

Animal Models for Obesity or affiliated genes

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Publications for Obesity

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Articles related to Obesity:

(show top 50)    (show all 8960)
idTitleAuthorsYear
1
Perceived weight in youths and risk of overweight or obesity six years later. (24360137)
2014
2
MicroRNA Functions in Brite/Brown Fat - Novel Perspectives towards Anti-Obesity Strategies. (25408843)
2014
3
Body Mass Index Categories and Mortality Risk in US Adults: The Effect of Overweight and Obesity on Advancing Death. (24432921)
2014
4
Substantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder. (23639407)
2013
5
Family Structure and Childhood Obesity: An Analysis Through 8th Grade. (24370680)
2013
6
Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children. (23510779)
2013
7
Influence of attention-deficit/hyperactivity disorder on binge eating behaviors and psychiatric comorbidity profile of obese women. (24246603)
2013
8
Surgically induced interpregnancy weight loss and prevalence of overweight and obesity in offspring. (24349234)
2013
9
Cystic fibrosis: from protein-energy malnutrition to obesity with dyslipidemia. (24800027)
2013
10
Uncoupling protein-2 45-base pair insertion/deletion polymorphism: is there an association with severe obesity and weight loss in morbidly obese subjects? (22568573)
2012
11
Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China. (21892197)
2011
12
GPR43: an emerging target for the potential treatment of type 2 diabetes, obesity and insulin resistance. (20336586)
2010
13
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
14
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch. (20492663)
2010
15
Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes. (19558533)
2010
16
Hypothalamic obesity complicated by adipsic central diabetes insipidus following surgical resection of a craniopharyngioma. (19817945)
2009
17
Obesity and polycystic ovary syndrome. (20054201)
2009
18
Evaluation of bone disease in morbidly obese women after gastric bypass and risk factors implicated in bone loss. (19412643)
2009
19
Obesity alters cytokine gene expression and promotes liver injury in rats with acute pancreatitis. (18223607)
2008
20
The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. (18295974)
2008
21
Metabolic effects of weight loss on a very-low-carbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects. (18174038)
2008
22
Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) study. (18452784)
2008
23
The preservation of insulin sensitivity in obese women without diabetes. (18672628)
2008
24
Novel melanocortin 4 receptor gene mutations in severely obese children. (17941900)
2008
25
Fibrinogen, plasma viscosity and blood viscosity in obesity. Relationship with insulin resistance. (17942983)
2007
26
Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in utah. (16741266)
2006
27
Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. (17065359)
2006
28
Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome. (16077717)
2005
29
Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. (15975705)
2005
30
Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance. (16182246)
2005
31
Superior mesenteric artery syndrome after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (15329194)
2004
32
Addition of rosiglitazone to metformin is most effective in obese, insulin-resistant patients with type 2 diabetes. (12681023)
2003
33
Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses. (12960083)
2003
34
Weight loss in a patient with morbid obesity under treatment with oleoyl-estrone]. (14588193)
2003
35
Central and peripheral glucocorticoid receptor function in abdominal obesity. (11936464)
2002
36
Resistin, obesity and insulin resistance--the emerging role of the adipocyte as an endocrine organ. (11794158)
2001
37
Overweight/obesity, smoking, and heavy alcohol consumption are important determinants of plasma PAI-1 levels in healthy men. (11465242)
2001
38
Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women. (11157312)
2001
39
A cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats. (10958832)
2000
40
Effect of opioid blockade on insulin and growth hormone (GH) secretion in patients with polycystic ovary syndrome: the heterogeneity of impaired GH secretion is related to both obesity and hyperinsulinism. (9935127)
1999
41
The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk. (9569171)
1998
42
A case of acanthosis nigricans in obese siblings with a pedigree of familial polyposis coli. (9330076)
1997
43
The beta(3)-adrenergic receptor TRP64ARG polymorphism and obesity in Alaskan Eskimos. (9426386)
1997
44
Determinants of the kinetics of very low-density lipoprotein apolipoprotein B-100 in non-obese men. (9269527)
1997
45
Pseudotumor cerebri in a patient with Bartter's syndrome and obesity. (8903869)
1996
46
Lipoprotein lipase gene polymorphisms: associations with hypertriglyceridemia and body mass index in obese people. (7627251)
1995
47
Hormones and obesity. (7980347)
1994
48
Arginine potentiates but does not restore the blunted growth hormone response to growth hormone-releasing hormone in obesity. (1588839)
1992
49
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. (1955512)
1991
50
Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats. (1939742)
1991

Variations for Obesity

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UniProtKB/Swiss-Prot genetic disease variations for Obesity:

64 (show all 30)
id Symbol AA change Variation ID SNP ID
1MC4Rp.Ser30ArgVAR_010704
2MC4Rp.Asp37ValVAR_010705rs13447325
3MC4Rp.Pro78LeuVAR_010706rs13447326
4MC4Rp.Arg165TrpVAR_010709rs13447332
5MC4Rp.Gly252SerVAR_010711rs13447336
6MC4Rp.Ile317ThrVAR_010712rs13447337
7MC4Rp.Asn274SerVAR_015357
8MC4Rp.Thr11AlaVAR_038632
9MC4Rp.Ser36TyrVAR_038633
10MC4Rp.Val50MetVAR_038634
11MC4Rp.Ser58CysVAR_038635
12MC4Rp.Asn62SerVAR_038636
13MC4Rp.Asn97AspVAR_038638
14MC4Rp.Ile102SerVAR_038639
15MC4Rp.Ile102ThrVAR_038640
16MC4Rp.Leu106ProVAR_038641
17MC4Rp.Ile125LysVAR_038642
18MC4Rp.Ser127LeuVAR_038643rs13447331
19MC4Rp.Arg165GlnVAR_038644rs13447332
20MC4Rp.Ile170ValVAR_038645rs121913560
21MC4Rp.Ala175ThrVAR_038646
22MC4Rp.Gly181AspVAR_038647rs13447333
23MC4Rp.Ala219ValVAR_038648
24MC4Rp.Val253IleVAR_038650rs187152753
25MC4Rp.Cys271ArgVAR_038651
26MC4Rp.Cys271TyrVAR_038652
27MC4Rp.Ile316SerVAR_038653
28MC4Rp.Leu325PheVAR_038654
29PPARGp.Pro113GlnVAR_010724rs1800571
30UCP3p.Val102IleVAR_004408rs2229707

Clinvar genetic disease variations for Obesity:

6 (show all 40)
id Gene Name Type Significance SNP ID Assembly Location
1ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
2ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
3ENPP1NM_006208.2(ENPP1): c.*1043A> Gsingle nucleotide variantrisk factorrs7754561GRCh37Chr 6, 132212694: 132212694
4MC4RMC4R, 4-BP DEL, NT631deletionPathogenic
5MC4RMC4R, 4-BP INS, NT732insertionPathogenic
6MC4RNM_005912.2(MC4R): c.105C> A (p.Tyr35Ter)single nucleotide variantPathogenicrs13447324GRCh37Chr 18, 58039478: 58039478
7MC4RNM_005912.2(MC4R): c.110A> T (p.Asp37Val)single nucleotide variantPathogenicrs13447325GRCh37Chr 18, 58039473: 58039473
8MC4RNM_005912.2(MC4R): c.148G> A (p.Val50Met)single nucleotide variantPathogenicrs121913557GRCh37Chr 18, 58039435: 58039435
9MC4RNM_005912.2(MC4R): c.172A> T (p.Ser58Cys)single nucleotide variantPathogenicrs121913558GRCh37Chr 18, 58039411: 58039411
10MC4RNM_005912.2(MC4R): c.305T> G (p.Ile102Ser)single nucleotide variantPathogenicrs121913559GRCh37Chr 18, 58039278: 58039278
11MC4RNM_005912.2(MC4R): c.508A> G (p.Ile170Val)single nucleotide variantPathogenicrs121913560GRCh37Chr 18, 58039075: 58039075
12MC4RNM_005912.2(MC4R): c.821A> G (p.Asn274Ser)single nucleotide variantPathogenicrs121913561GRCh37Chr 18, 58038762: 58038762
13MC4RMC4R, 1-BP INS, 112AinsertionPathogenic
14MC4RMC4R, 4-BP DEL, 211CTCTdeletionPathogenic
15MC4RMC4R, 2-BP INS, 279GTinsertionPathogenic
16MC4RMC4R, ILE125LYSundetermined variantPathogenic
17MC4RNM_005912.2(MC4R): c.812G> A (p.Cys271Tyr)single nucleotide variantPathogenicrs121913562GRCh37Chr 18, 58038771: 58038771
18MC4RNM_005912.2(MC4R): c.523G> A (p.Ala175Thr)single nucleotide variantPathogenicrs121913563GRCh37Chr 18, 58039060: 58039060
19MC4RNM_005912.2(MC4R): c.947T> G (p.Ile316Ser)single nucleotide variantPathogenicrs121913564GRCh37Chr 18, 58038636: 58038636
20MC4RNM_005912.2(MC4R): c.861T> A (p.Tyr287Ter)single nucleotide variantPathogenicrs121917829GRCh37Chr 18, 58038722: 58038722
21MC4RNM_005912.2(MC4R): c.289A> G (p.Asn97Asp)single nucleotide variantPathogenicrs121913565GRCh37Chr 18, 58039294: 58039294
22MC4RNM_005912.2(MC4R): c.185A> G (p.Asn62Ser)single nucleotide variantPathogenicrs121913566GRCh37Chr 18, 58039398: 58039398
23MC4RMC4R, 15-BP DELdeletionPathogenic
24MC4RNM_005912.2(MC4R): c.380C> T (p.Ser127Leu)single nucleotide variantPathogenicrs13447331GRCh37Chr 18, 58039203: 58039203
25MC4RMC4R, 2-BP DEL, 750GAdeletionPathogenic
26MC4RNM_005912.2(MC4R): c.656C> T (p.Ala219Val)single nucleotide variantPathogenicrs121913567GRCh37Chr 18, 58038927: 58038927
27ADRB3NM_000025.2(ADRB3): c.190T> C (p.Trp64Arg)single nucleotide variantrisk factorrs4994GRCh37Chr 8, 37823798: 37823798
28ADRB2NM_000024.5(ADRB2): c.79C> G (p.Gln27Glu)single nucleotide variantrisk factorrs1042714GRCh37Chr 5, 148206473: 148206473
29FFAR4NM_181745.3(FFAR4): c.809G> A (p.Arg270His)single nucleotide variantrisk factorrs116454156GRCh37Chr 10, 95347041: 95347041
30LEPRNM_002303.5(LEPR): c.2880C> G (p.Asn960Lys)single nucleotide variantLikely pathogenicrs193922650GRCh37Chr 1, 66102080: 66102080
31MC4RNM_005912.2(MC4R): c.538T> C (p.Ser180Pro)single nucleotide variantLikely pathogenicrs193922685GRCh37Chr 18, 58039045: 58039045
32MC4RNM_005912.2(MC4R): c.806T> A (p.Ile269Asn)single nucleotide variantLikely pathogenicrs79783591GRCh37Chr 18, 58038777: 58038777
33MC4RNM_005912.2(MC4R): c.835_836dupTG (p.Phe280Alafs)duplicationPathogenicrs193922687GRCh37Chr 18, 58038746: 58038747
34MC4RNM_005912.2(MC4R): c.896C> A (p.Pro299His)single nucleotide variantPathogenicrs52804924GRCh37Chr 18, 58038687: 58038687
35NM_001134944.1(GHRL): c.116G> A (p.Arg39Gln)single nucleotide variantrisk factorrs34911341GRCh37Chr 3, 10331519: 10331519
36NM_001134944.1(GHRL): c.233A> T (p.Gln78Leu)single nucleotide variantrisk factorrs4684677GRCh37Chr 3, 10328453: 10328453
37MRAP2NM_138409.2(MRAP2): c.70G> T (p.Glu24Ter)single nucleotide variantrisk factorGRCh37Chr 6, 84765107: 84765107
38CARTPTNM_004291.3(CARTPT): c.183G> C (p.Leu61Phe)single nucleotide variantrisk factorrs121909065GRCh37Chr 5, 71015730: 71015730
39PYYNM_004160.4(PYY): c.185A> C (p.Gln62Pro)single nucleotide variantrisk factorrs267606994GRCh37Chr 17, 42030667: 42030667
40MT-CYBm.15497G> Asingle nucleotide variantrisk factorrs199951903GRCh37Chr MT, 15497: 15497

Expression for genes affiliated with Obesity

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Expression patterns in normal tissues for genes affiliated with Obesity

Search GEO for disease gene expression data for Obesity.

Pathways for genes affiliated with Obesity

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Pathways related to Obesity according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.9LEPR, FFAR4, GHRL, ADRB2, ADRB3, PYY
2
Show member pathways
10.9POMC, LEPR, LEP, FFAR4, MC3R, PYY
3
Show member pathways
10.8MT-CYB, POMC, PPARG, UCP1, GAD1, ENPP1
4
Show member pathways
10.7UCP3, MT-CYB, LEPR, LEP, PPARG, UCP1
5
Show member pathways
10.7ADRB3, UCP1, POMC, ADRB2, PPARG
610.7POMC, ADRB3, ADRB2, MC3R, MC4R
7
Show member pathways
10.7POMC, FFAR4, GHRL, LEP
810.6PPARG, LEP, UCP1
910.6POMC, LEP, LEPR
10
Show member pathways
10.6LEPR, LEP, POMC
1110.6PYY, ADRB2
12
Show member pathways
10.6UCP1, UCP3
13
Show member pathways
10.6LEP, FFAR4
1410.6POMC, MC4R

Compounds for genes affiliated with Obesity

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Compounds related to Obesity according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1glucose4411.6LEPR, GHRL, MT-CYB, ADRB2, PPARG, PYY
2lipid4411.5MT-CYB, ADRB2, ADRB3, MC4R, MC3R, LEP
3fatty acid4411.4PYY, LEPR, LEP, MC4R, GHRL, UCP3
4cholesterol44 28 24 1114.4ADRB3, GAD1, UCP1, UCP3, PYY, LEPR
5alanine4411.3LEPR, PPARG, GAD1, UCP1, GHRL, MT-CYB
6cocaine44 1112.3POMC, PYY, ADRB2, GHRL, CARTPT, MC3R
7dopamine44 28 24 1114.3LEPR, POMC, ADRB2, GHRL, CARTPT, MC4R
8arginine4411.3LEPR, LEP, MC4R, ADRB3, GHRL, POMC
9nitric oxide44 24 1113.3ADRB3, MC4R, MT-CYB, LEPR, UCP3, UCP1
10norepinephrine44 24 1113.3GHRL, LEP, POMC, ADRB3, UCP3, ADRB2
11gnrh4411.3PYY, GAD1, GHRL, ADRB2, POMC, LEPR
12estrogen4411.3POMC, UCP3, PPARG, LEP, PYY, LEPR
13cyclic amp44 2412.2ADRB3, MC3R, PYY, ADRB2, GHRL, CARTPT
14clozapine44 28 50 1114.2LEP, MC4R, POMC, ADRB3, GHRL, GAD1
15acth4411.2MC3R, PYY, GHRL, LEPR, LEP, MC4R
16dexamethasone44 50 28 1114.2PPARG, LEPR, ENPP1, POMC, ADRB3, ADRB2
17c-peptide4411.2PYY, UCP1, GHRL, LEP, ADRB3, GAD1
182-deoxyglucose44 1112.2GAD1, UCP3, GHRL, POMC, PYY, PPARG
19triiodothyronine4411.2LEPR, POMC, GHRL, UCP3, LEP, UCP1
20hydrogen44 2412.2ADRB2, MT-CYB, PYY, GHRL, UCP3, GAD1
21corticosterone44 61 2413.1LEPR, GHRL, POMC, MC4R, MC3R, LEP
22thyroxine44 2412.1POMC, UCP1, LEP, LEPR, PPARG, GHRL
23oxygen44 2412.1ADRB3, MT-CYB, ADRB2, GAD1, UCP1, UCP3
24gaba4411.1PYY, POMC, GAD1, GHRL, ADRB2, LEP
25amphetamine44 50 1113.1MC4R, GHRL, POMC, CARTPT, PYY
26metformin44 50 1113.1POMC, ENPP1, PPARG, LEP, GHRL
27olanzapine44 50 28 24 1115.1ADRB3, LEP, GHRL, LEPR, MC4R
28shu 911961 4412.1LEP, MC3R, MC4R, POMC
29serine4411.1ADRB2, LEP, LEPR, GHRL, UCP1, POMC
30testosterone44 61 24 1114.0UCP1, PPARG, LEPR, LEP, POMC, ADRB2
31alpha msh4411.0POMC, LEP, MC3R, MC4R
32intralipid4411.0LEP, UCP3, PYY, GHRL
33acetylcholine44 50 28 24 1115.0GAD1, ADRB2, POMC, LEP, PYY, GHRL
34orlistat44 61 1113.0PPARG, LEP, PYY, GHRL
35rosiglitazone28 44 50 24 1115.0LEP, UCP3, UCP1, GHRL, PPARG
36thiazolidinedione4411.0UCP3, PPARG, LEP, UCP1
37potassium44 24 1113.0ADRB2, MT-CYB, LEPR, ADRB3, GAD1, GHRL
38estradiol44 24 1112.9GHRL, LEP, GAD1, PYY, LEPR, POMC
39[d-trp8]-gamma-msh6110.9MC4R, POMC, MC3R
40alpha-msh61 2811.9MC3R, POMC, MC4R
41pg 1066110.9POMC, MC4R, MC3R
42hs 0146110.9MC3R, POMC, MC4R
43naloxone44 28 50 1113.9GHRL, POMC, ADRB2, LEP
44glutamine4410.9PPARG, POMC, GAD1, ENPP1, LEPR, ADRB2
45vegf4410.8LEP, LEPR, PPARG, POMC, UCP3, ADRB2
46clenbuterol44 1111.8LEP, ADRB3, ADRB2
47opiate4410.7ADRB2, MC4R, GHRL, POMC
48triacylglycerol4410.7LEP, PYY, GHRL, LEPR
49pramlintide44 1111.5PYY, LEP, GHRL
50stavudine44 1111.3LEP, PPARG, UCP1

GO Terms for genes affiliated with Obesity

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Cellular components related to Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.8MRAP2, LEPR, FFAR4, MC3R, MC4R, ADRB3
2extracellular spaceGO:00561510.7ENPP1, PYY, LEP, POMC, GHRL, CARTPT
3receptor complexGO:04323510.6ADRB2, ADRB3, LEPR
4secretory granule lumenGO:03477410.3GHRL, POMC

Biological processes related to Obesity according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1energy reserve metabolic processGO:00611211.0ADRB3, MRAP2, LEPR, LEP, MC4R
2brown fat cell differentiationGO:05087311.0UCP1, ADRB3, PPARG, ADRB2
3response to coldGO:00940911.0ADRB3, UCP3, ADRB2, PPARG
4adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718811.0MC4R, ADRB3, ADRB2, MC3R
5regulation of blood pressureGO:00821711.0LEP, PPARG, MC3R, POMC
6diet induced thermogenesisGO:00202410.9MC4R, ADRB2, ADRB3
7adult feeding behaviorGO:00834310.9LEP, CARTPT, GHRL
8eating behaviorGO:04275510.9PYY, ADRB3, LEP
9feeding behaviorGO:00763110.9PYY, MRAP2, MC4R
10positive regulation of cAMP biosynthetic processGO:03081910.9MC3R, MRAP2, MC4R
11heat generationGO:03164910.8ADRB2, ADRB3
12vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:00202510.8ADRB2, ADRB3
13desensitization of G-protein coupled receptor protein signaling pathway by arrestinGO:00203210.8ADRB3, ADRB2
14response to insulinGO:03286810.8LEP, MC4R, UCP3
15generation of precursor metabolites and energyGO:00609110.8POMC, ADRB3, ENPP1
16negative regulation of glucagon secretionGO:07009310.8LEP, CARTPT
17positive regulation of MAPK cascadeGO:04341010.8ADRB3, ADRB2, LEP
18adrenergic receptor signaling pathwayGO:07187510.7ADRB3, ADRB2
19G-protein coupled receptor signaling pathwayGO:00718610.7CARTPT, GHRL, PYY, PPARG
20negative regulation of appetiteGO:03209910.6CARTPT, LEP
21adipose tissue developmentGO:06061210.6FTO, LEP
22negative regulation of multicellular organism growthGO:04001510.5ADRB2, ADRB3
23mitochondrial transportGO:00683910.3UCP3, UCP1

Molecular functions related to Obesity according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1oxidative phosphorylation uncoupler activityGO:01707710.8UCP1, UCP3
2melanocyte-stimulating hormone receptor activityGO:00498010.8MC4R, MC3R
3type 1 melanocortin receptor bindingGO:07099610.8POMC, MRAP2
4norepinephrine bindingGO:05138010.8ADRB3, ADRB2
5type 4 melanocortin receptor bindingGO:03178210.7MRAP2, POMC
6type 3 melanocortin receptor bindingGO:03178110.7MRAP2, POMC
7protein bindingGO:00551510.7PPARG, PYY, LEPR, MC3R, MC4R, ADRB3
8melanocortin receptor activityGO:00497710.6MC4R, MC3R
9neuropeptide bindingGO:04292310.6MC4R, MC3R
10peptide hormone bindingGO:01704610.6MC4R, MC3R
11hormone activityGO:00517910.5PYY, LEP, POMC

Products for genes affiliated with Obesity

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  • Antibodies
  • Proteins
  • Lysates

Sources for Obesity

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet