MCID: OBS005
MIFTS: 89

Obesity malady

Genetic diseases, Rare diseases categories

Summaries for Obesity

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35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Obesity means having too much body fat. it is different from being overweight, which means weighing too much. the weight may come from muscle, bone, fat, and/or body water. both terms mean that a person's weight is greater than what's considered healthy for his or her height. obesity occurs over time when you eat more calories than you use. the balance between calories-in and calories-out differs for each person. factors that might affect your weight include your genetic makeup, overeating, eating high-fat foods, and not being physically active. being obese increases your risk of diabetes, heart disease, stroke, arthritis, and some cancers. if you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases. for example, that means losing 10 to 20 pounds if you weigh 200 pounds. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Obesity is related to insulin resistance and morbid obesity. An important gene associated with Obesity is PYY (peptide YY), and among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs fenfluramine and fenfluramine hydrochloride and the compounds glucose and lipid have been mentioned in the context of this disorder. Affiliated tissues include liver, ovary and heart, and related mouse phenotypes are adipose tissue and homeostasis/metabolism.

Wikipedia:66 Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a... more...

Description from OMIM:48 601665,607514

Aliases & Classifications for Obesity

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 21GeneTests, 23GTR, 48OMIM, 46Novoseek, 35MedlinePlus, 63UMLS, 36MeSH, 59SNOMED-CT, 28ICD9CM, 41NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases


Aliases & Descriptions:

obesity 9 44 21 23 48 46 35 63


External Ids:

Disease Ontology9 DOID:9970
OMIM48 601665
MeSH36 D009765
ICD9CM28 278.00
NCIt41 C3283

Related Diseases for Obesity

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Obesity family:

Obesity, Mc4r-Related Obesity, Pparg-Related
Obesity, Susceptibility to, Cartpt-Related Obesity, Susceptibility to, Mc3r-Related
Obesity, Ucp3-Related Obesity, Pyy-Related
Obesity, Sim1-Related Obesity, Early-Onset
Obesity, Late-Onset

Diseases related to Obesity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 719)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance32.0PPARG, PYY, ENPP1, UCP1, UCP3, GHRL
2morbid obesity31.9FTO, MC4R, MC3R, LEP, LEPR, PYY
3hypertension31.7ADRB2, ADRB3, POMC, LEP, PPARG
4diabetes mellitus31.6ENPP1, UCP1, UCP3, GHRL, FTO, ADRB3
5polycystic ovary syndrome31.5GHRL, LEP
6type 2 diabetes mellitus31.4ADRB2, ADRB3, MC4R, LEP, LEPR, PYY
7fatty liver disease31.3PPARG, LEPR, LEP, ADRB3
8eating disorder31.3PYY, LEP, GHRL
9atherosclerosis31.2PPARG, LEPR, LEP, ADRB3, ADRB2, GHRL
10prader-willi syndrome31.2PYY, LEPR, LEP, GHRL
11glucose intolerance31.1GHRL, PYY
12hyperandrogenism31.1POMC, MC4R, LEP, PPARG
13gestational diabetes31.1LEPR, LEP, ADRB3, ENPP1
14breast cancer31.0PPARG, PYY, LEPR, LEP, ADRB3, ENPP1
15anorexia nervosa31.0PYY, LEPR, LEP, MC3R, MC4R, POMC
16hypertriglyceridemia31.0PPARG, LEP, ADRB3
17hypogonadism31.0LEP, POMC, GHRL
18hyperglycemia30.9PPARG, PYY, LEPR, LEP, POMC, ADRB3
19hyperinsulinism30.9PPARG, LEPR, LEP, MC4R, GHRL
20essential hypertension30.8LEPR, LEP, ADRB3, ADRB2
21cushing's syndrome30.8GHRL, POMC, LEP
22metabolic syndrome x30.7LEP, PPARG
23hypothyroidism30.7GHRL, LEP
24bulimia nervosa30.6GHRL, MC4R
25coronary artery disease30.6LEP, ADRB3, ADRB2
26lipodystrophy30.6PPARG, LEP, ADRB3
27type 1 diabetes mellitus30.6LEPR, LEP, ADRB3, ADRB2, UCP1, ENPP1
28arthritis30.6LEP, POMC, ADRB2, GHRL
29growth hormone deficiency30.5GHRL, POMC, LEP
30hypopituitarism30.5GHRL, POMC, LEP
31hypoglycemia30.4POMC, ADRB2, GHRL
32precocious puberty30.4POMC, LEP
33insulinoma30.3UCP1, GHRL, LEPR
34anovulation30.3GHRL, LEP
35adenoma30.3PPARG, PYY, LEPR, POMC, GHRL
36pre-eclampsia30.3LEPR, LEP, ADRB3, ADRB2
37diabetic nephropathy30.3PPARG, ADRB3, UCP1, ENPP1
38familial combined hyperlipidemia30.2ADRB3, LEPR
39familial partial lipodystrophy30.2LEP, PPARG
40bronchitis30.0GHRL, MC4R, LEP
41amenorrhea30.0LEP, POMC
42adrenal gland hyperfunction29.8LEP, POMC, GHRL
43pheochromocytoma29.8PYY, POMC, ADRB2, UCP1
44acth deficiency29.8MC4R, POMC
45liver disease10.8
46hepatitis10.8
47endotheliitis10.6
48sleep apnea10.6
49acanthosis nigricans10.6
50obstructive sleep apnea10.6

Graphical network of the top 20 diseases related to Obesity:



Diseases related to obesity

Symptoms for Obesity

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Sources:
48OMIM
See all sources


Clinical features from OMIM:

601665,607514

Drugs & Therapeutics for Obesity

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Obesity

Drug clinical trials:

Search ClinicalTrials for Obesity

Search NIH Clinical Center for Obesity

Highlights from CenterWatch's Drugs in Clinical Trials Database for Obesity:

idCompanyCompoundMechanismPhase
1Ablaris TherapeuticsAdipotideA Prohibitin-Targeting Peptide 1I
2Zafgenbeloranib hemioxalatea MetAP2 inhibitor IIa
3Rhythm PharmaceuticalsRM-493a small-peptide MC4R agonistII
4High Point PharmaceuticalsHPP404A selective H3 receptor antagonistII
5Novo Nordiskliraglutidea GLP-1 derivativeIII

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Obesity

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Sources:
21GeneTests, 23GTR
See all sources

Genetic tests related to Obesity:

id Genetic test Affiliating Genes
1 Obesity21 23

Anatomical Context for Obesity

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34MalaCards
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MalaCards organs/tissues related to Obesity:

34
Liver, Ovary, Heart, Adipocyte, Skeletal muscle, Bone, Kidney, Endothelial, Breast, Testes, Thyroid, Brain, Pituitary, Prostate, Monocytes, T cells, Colon, Skin, Lung, Hypothalamus, B cells, Pancreatic islet, Spinal cord, Pancreas, Myeloid, Salivary gland, Bone marrow, Lymph node, Small intestine, Placenta, Smooth muscle, Amygdala, Adrenal cortex, Pons, Spleen, Retina, Cerebellum, Eye, Nk cells, Whole blood, Cortex, Testis, Thymus

Animal Models for Obesity or affiliated genes

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38MGI
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Publications for Obesity

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Sources:
53PubMed
See all sources

Articles related to Obesity:

(show top 50)    (show all 8678)
idTitleAuthorsYear
1
Perceived weight in youths and risk of overweight or obesity six years later. (24360137)
2014
2
Body Mass Index Categories and Mortality Risk in US Adults: The Effect of Overweight and Obesity on Advancing Death. (24432921)
2014
3
Obesity has multifaceted impact on biochemical recurrence of prostate cancer: a dose-response meta-analysis of 36,927 patients. (24390417)
2014
4
Substantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder. (23639407)
2013
5
Family Structure and Childhood Obesity: An Analysis Through 8th Grade. (24370680)
2013
6
Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children. (23510779)
2013
7
Influence of attention-deficit/hyperactivity disorder on binge eating behaviors and psychiatric comorbidity profile of obese women. (24246603)
2013
8
Surgically induced interpregnancy weight loss and prevalence of overweight and obesity in offspring. (24349234)
2013
9
Uncoupling protein-2 45-base pair insertion/deletion polymorphism: is there an association with severe obesity and weight loss in morbidly obese subjects? (22568573)
2012
10
Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China. (21892197)
2011
11
GPR43: an emerging target for the potential treatment of type 2 diabetes, obesity and insulin resistance. (20336586)
2010
12
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
13
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch. (20492663)
2010
14
Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes. (19558533)
2010
15
Hypothalamic obesity complicated by adipsic central diabetes insipidus following surgical resection of a craniopharyngioma. (19817945)
2009
16
Obesity and polycystic ovary syndrome. (20054201)
2009
17
Evaluation of bone disease in morbidly obese women after gastric bypass and risk factors implicated in bone loss. (19412643)
2009
18
The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. (18295974)
2008
19
Metabolic effects of weight loss on a very-low-carbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects. (18174038)
2008
20
Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) study. (18452784)
2008
21
The preservation of insulin sensitivity in obese women without diabetes. (18672628)
2008
22
Double-blind, randomized trial comparing efficacy and safety of continuing olanzapine versus switching to quetiapine in overweight or obese patients with schizophrenia or schizoaffective disorder. (19209252)
2008
23
Novel melanocortin 4 receptor gene mutations in severely obese children. (17941900)
2008
24
Fibrinogen, plasma viscosity and blood viscosity in obesity. Relationship with insulin resistance. (17942983)
2007
25
Plasma orexin and ghrelin response to the oral glucose tolerance test in obese women. (18058738)
2007
26
Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in utah. (16741266)
2006
27
Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. (17065359)
2006
28
Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome. (16077717)
2005
29
Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. (15975705)
2005
30
Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance. (16182246)
2005
31
Superior mesenteric artery syndrome after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (15329194)
2004
32
Addition of rosiglitazone to metformin is most effective in obese, insulin-resistant patients with type 2 diabetes. (12681023)
2003
33
Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses. (12960083)
2003
34
Weight loss in a patient with morbid obesity under treatment with oleoyl-estrone]. (14588193)
2003
35
Central and peripheral glucocorticoid receptor function in abdominal obesity. (11936464)
2002
36
Resistin, obesity and insulin resistance--the emerging role of the adipocyte as an endocrine organ. (11794158)
2001
37
Overweight/obesity, smoking, and heavy alcohol consumption are important determinants of plasma PAI-1 levels in healthy men. (11465242)
2001
38
Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women. (11157312)
2001
39
A cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats. (10958832)
2000
40
Effect of opioid blockade on insulin and growth hormone (GH) secretion in patients with polycystic ovary syndrome: the heterogeneity of impaired GH secretion is related to both obesity and hyperinsulinism. (9935127)
1999
41
The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk. (9569171)
1998
42
A case of acanthosis nigricans in obese siblings with a pedigree of familial polyposis coli. (9330076)
1997
43
The beta(3)-adrenergic receptor TRP64ARG polymorphism and obesity in Alaskan Eskimos. (9426386)
1997
44
Determinants of the kinetics of very low-density lipoprotein apolipoprotein B-100 in non-obese men. (9269527)
1997
45
Pseudotumor cerebri in a patient with Bartter's syndrome and obesity. (8903869)
1996
46
Lipoprotein lipase gene polymorphisms: associations with hypertriglyceridemia and body mass index in obese people. (7627251)
1995
47
Hormones and obesity. (7980347)
1994
48
Arginine potentiates but does not restore the blunted growth hormone response to growth hormone-releasing hormone in obesity. (1588839)
1992
49
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. (1955512)
1991
50
Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats. (1939742)
1991

Variations for Obesity

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Obesity:

65 (show all 30)
id Symbol AA change Variation ID SNP ID
1MC4Rp.Ser30ArgVAR_010704
2MC4Rp.Asp37ValVAR_010705rs13447325
3MC4Rp.Pro78LeuVAR_010706rs13447326
4MC4Rp.Arg165TrpVAR_010709rs13447332
5MC4Rp.Gly252SerVAR_010711rs13447336
6MC4Rp.Ile317ThrVAR_010712rs13447337
7MC4Rp.Asn274SerVAR_015357
8MC4Rp.Thr11AlaVAR_038632
9MC4Rp.Ser36TyrVAR_038633
10MC4Rp.Val50MetVAR_038634
11MC4Rp.Ser58CysVAR_038635
12MC4Rp.Asn62SerVAR_038636
13MC4Rp.Asn97AspVAR_038638
14MC4Rp.Ile102SerVAR_038639
15MC4Rp.Ile102ThrVAR_038640
16MC4Rp.Leu106ProVAR_038641
17MC4Rp.Ile125LysVAR_038642
18MC4Rp.Ser127LeuVAR_038643rs13447331
19MC4Rp.Arg165GlnVAR_038644rs13447332
20MC4Rp.Ile170ValVAR_038645rs121913560
21MC4Rp.Ala175ThrVAR_038646
22MC4Rp.Gly181AspVAR_038647rs13447333
23MC4Rp.Ala219ValVAR_038648
24MC4Rp.Val253IleVAR_038650rs187152753
25MC4Rp.Cys271ArgVAR_038651
26MC4Rp.Cys271TyrVAR_038652
27MC4Rp.Ile316SerVAR_038653
28MC4Rp.Leu325PheVAR_038654
29PPARGp.Pro113GlnVAR_010724rs1800571
30UCP3p.Val102IleVAR_004408rs2229707

Clinvar genetic disease variations for Obesity:

1 (show all 25)
id Gene Name Type Significance SNP ID Assembly Location
1MC4RMC4R, 4-BP DEL, NT631deletionPathogenic
2MC4RMC4R, 4-BP INS, NT732insertionPathogenic
3MC4RNM_005912.2(MC4R): c.105C> A (p.Tyr35Ter)single nucleotide variantPathogenicrs13447324GRCh37Chr 18, 58039478: 58039478
4MC4RNM_005912.2(MC4R): c.110A> T (p.Asp37Val)single nucleotide variantPathogenic, Uncertain significancers13447325GRCh37Chr 18, 58039473: 58039473
5MC4RNM_005912.2(MC4R): c.148G> A (p.Val50Met)single nucleotide variantPathogenicrs121913557GRCh37Chr 18, 58039435: 58039435
6MC4RNM_005912.2(MC4R): c.172A> T (p.Ser58Cys)single nucleotide variantPathogenicrs121913558GRCh37Chr 18, 58039411: 58039411
7MC4RNM_005912.2(MC4R): c.305T> G (p.Ile102Ser)single nucleotide variantPathogenicrs121913559GRCh37Chr 18, 58039278: 58039278
8MC4RNM_005912.2(MC4R): c.508A> G (p.Ile170Val)single nucleotide variantPathogenicrs121913560GRCh37Chr 18, 58039075: 58039075
9MC4RNM_005912.2(MC4R): c.821A> G (p.Asn274Ser)single nucleotide variantPathogenicrs121913561GRCh37Chr 18, 58038762: 58038762
10MC4RMC4R, 1-BP INS, 112AinsertionPathogenic
11MC4RMC4R, 4-BP DEL, 211CTCTdeletionPathogenic
12MC4RMC4R, 2-BP INS, 279GTinsertionPathogenic
13MC4RMC4R, ILE125LYSundetermined variantPathogenic
14MC4RNM_005912.2(MC4R): c.812G> A (p.Cys271Tyr)single nucleotide variantPathogenicrs121913562GRCh37Chr 18, 58038771: 58038771
15MC4RNM_005912.2(MC4R): c.523G> A (p.Ala175Thr)single nucleotide variantPathogenicrs121913563GRCh37Chr 18, 58039060: 58039060
16MC4RNM_005912.2(MC4R): c.947T> G (p.Ile316Ser)single nucleotide variantPathogenicrs121913564GRCh37Chr 18, 58038636: 58038636
17MC4RNM_005912.2(MC4R): c.861T> A (p.Tyr287Ter)single nucleotide variantPathogenicrs121917829GRCh37Chr 18, 58038722: 58038722
18MC4RNM_005912.2(MC4R): c.289A> G (p.Asn97Asp)single nucleotide variantPathogenicrs121913565GRCh37Chr 18, 58039294: 58039294
19MC4RNM_005912.2(MC4R): c.185A> G (p.Asn62Ser)single nucleotide variantPathogenicrs121913566GRCh37Chr 18, 58039398: 58039398
20MC4RMC4R, 15-BP DELdeletionPathogenic
21MC4RNM_005912.2(MC4R): c.380C> T (p.Ser127Leu)single nucleotide variantPathogenicrs13447331GRCh37Chr 18, 58039203: 58039203
22MC4RMC4R, 2-BP DEL, 750GAdeletionPathogenic
23MC4RNM_005912.2(MC4R): c.656C> T (p.Ala219Val)single nucleotide variantPathogenicrs121913567GRCh37Chr 18, 58038927: 58038927
24MC4RNM_005912.2(MC4R): c.835_836dupTG (p.Phe280Alafs)duplicationPathogenicrs193922687GRCh37Chr 18, 58038746: 58038747
25MC4RNM_005912.2(MC4R): c.896C> A (p.Pro299His)single nucleotide variantPathogenicrs52804924GRCh37Chr 18, 58038687: 58038687

Expression for genes affiliated with Obesity

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2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Obesity

Search GEO for disease gene expression data for Obesity.

Pathways for genes affiliated with Obesity

About this section
Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 52PharmGKB
See all sources

Pathways related to Obesity according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.8PYY, LEPR, LEP, FFAR4, MC3R, MC4R
2
Show member pathways
10.8GHRL, PYY, LEPR, LEP, FFAR4, MC3R
3
Show member pathways
10.6PPARG, POMC, ADRB3, ADRB2, UCP1
410.6MC3R, MC4R, POMC, ADRB3, ADRB2
5
Show member pathways
10.6PPARG, LEPR, LEP, UCP3, UCP1
6
Show member pathways
10.6LEP, FFAR4, POMC, GHRL
710.6UCP1, LEP, PPARG
8
Show member pathways
10.6POMC, LEP, LEPR
910.6POMC, LEP, LEPR
1010.5ADRB2, PYY
11
Show member pathways
10.5UCP1, UCP3
12
Show member pathways
10.5FFAR4, LEP
1310.5MC4R, POMC

Compounds for genes affiliated with Obesity

About this section
Sources:
46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
See all sources

Compounds related to Obesity according to GeneCards/GeneDecks:

(show top 50)    (show all 132)
idCompoundScoreTop Affiliating Genes
1glucose4611.3LEPR, PYY, POMC, PPARG, LEP, MC4R
2lipid4611.3LEP, LEPR, PYY, PPARG, MC3R, MC4R
3fatty acid4611.2PYY, PPARG, LEP, LEPR, MC4R, GHRL
4cholesterol46 30 25 1214.2PYY, LEPR, LEP, MC4R, ADRB3, GHRL
5norepinephrine46 25 1213.2UCP1, UCP3, GHRL, ADRB2, ADRB3, POMC
6cocaine46 1212.2PYY, LEPR, POMC, MC3R, MC4R, GHRL
7estrogen4611.2LEPR, PYY, UCP3, ADRB2, POMC, ADRB3
8acth4611.1POMC, MC4R, PYY, LEPR, LEP, MC3R
9gnrh4611.1POMC, GHRL, ADRB2, MC3R, LEP, LEPR
10dexamethasone46 52 30 1214.1POMC, LEPR, PPARG, LEP, ENPP1, GHRL
11arginine4611.1ADRB2, PYY, MC4R, GHRL, LEP, POMC
12alanine4611.1PPARG, LEPR, MC4R, POMC, ADRB3, ADRB2
13triiodothyronine4611.1LEP, UCP3, GHRL, POMC, LEPR, UCP1
14clozapine46 30 52 1214.1ADRB3, GHRL, ADRB2, POMC, MC4R, LEP
15dopamine46 30 25 1214.1MC3R, LEPR, GHRL, ADRB2, PYY, POMC
16corticosterone46 62 2513.1MC4R, POMC, GHRL, LEP, LEPR, MC3R
17thyroxine46 2512.1UCP1, PPARG, LEPR, LEP, POMC, GHRL
18cyclic amp46 2512.1ENPP1, GHRL, ADRB2, ADRB3, PYY, MC3R
19c-peptide4611.1UCP1, ADRB3, LEP, PYY, GHRL
202-deoxyglucose46 1212.0POMC, PPARG, GHRL, PYY, UCP3
21metformin46 52 1213.0POMC, ENPP1, GHRL, LEP, PPARG
22olanzapine46 52 30 25 1215.0ADRB3, LEPR, GHRL, LEP, MC4R
23shu 911962 4612.0LEP, MC3R, POMC, MC4R
24testosterone46 62 25 1214.0LEP, LEPR, PPARG, GHRL, UCP1, POMC
25alpha msh4611.0MC4R, MC3R, POMC, LEP
26intralipid4611.0UCP3, GHRL, LEP, PYY
27orlistat46 62 1213.0PPARG, PYY, LEP, GHRL
28vegf4611.0GHRL, ADRB2, LEP, PPARG, LEPR, POMC
29thiazolidinedione4611.0PPARG, LEP, UCP3, UCP1
30rosiglitazone30 46 52 25 1215.0PPARG, LEP, GHRL, UCP3, UCP1
31nitric oxide46 25 1212.9ADRB2, UCP1, GHRL, ADRB3, MC4R, UCP3
32alpha-msh62 3011.9MC4R, POMC, MC3R
33naloxone46 30 52 1213.9POMC, LEP, ADRB2, GHRL
34pg 1066210.9POMC, MC4R, MC3R
35amphetamine46 52 1212.9PYY, MC4R, GHRL, POMC
36hs 0146210.9POMC, MC4R, MC3R
37[d-trp8]-gamma-msh6210.9MC3R, POMC, MC4R
38opiate4610.9GHRL, ADRB2, POMC, MC4R
39clenbuterol46 1211.9ADRB2, LEP, ADRB3
40pramlintide46 1211.8PYY, LEP, GHRL
41gaba4610.8ADRB2, GHRL, PYY, POMC, LEP
42stavudine46 1211.8PPARG, LEP, UCP1
43triacylglycerol4610.8PYY, GHRL, LEP, LEPR
44epinephrine46 25 1212.8ADRB3, ADRB2, GHRL, POMC, LEP
45ribonucleic acid4610.7LEPR, POMC, GHRL, UCP3, UCP1
46acipimox46 3011.7UCP3, GHRL, LEP
47catecholamine4610.6UCP1, ADRB2, ADRB3, POMC
48palmitate4610.6PPARG, MC4R, UCP1, UCP3
49oxyntomodulin46 6211.5GHRL, LEP, PYY
50p0034610.3UCP1, UCP3, LEP, PYY

GO Terms for genes affiliated with Obesity

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17Gene Ontology
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Cellular components related to Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.6LEP, POMC, GHRL, ENPP1, PYY
2secretory granule lumenGO:03477410.4GHRL, POMC
3receptor complexGO:04323510.3ADRB2, ADRB3, LEPR

Biological processes related to Obesity according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1brown fat cell differentiationGO:05087310.9UCP1, ADRB2, ADRB3, PPARG
2response to coldGO:00940910.9PPARG, ADRB3, ADRB2, UCP3
3adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.9ADRB2, ADRB3, MC4R, MC3R
4regulation of blood pressureGO:00821710.9POMC, MC3R, LEP, PPARG
5diet induced thermogenesisGO:00202410.9MC4R, ADRB3, ADRB2
6energy reserve metabolic processGO:00611210.9LEPR, LEP, MC4R, ADRB3
7eating behaviorGO:04275510.8PYY, LEP, ADRB3
8vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:00202510.8ADRB2, ADRB3
9desensitization of G-protein coupled receptor protein signaling pathway by arrestinGO:00203210.8ADRB2, ADRB3
10heat generationGO:03164910.7ADRB2, ADRB3
11response to insulinGO:03286810.7LEP, MC4R, UCP3
12generation of precursor metabolites and energyGO:00609110.7ENPP1, ADRB3, POMC
13positive regulation of MAPK cascadeGO:04341010.7LEP, ADRB3, ADRB2
14adrenergic receptor signaling pathwayGO:07187510.6ADRB2, ADRB3
15adult feeding behaviorGO:00834310.5GHRL, LEP
16adipose tissue developmentGO:06061210.5FTO, LEP
17negative regulation of multicellular organism growthGO:04001510.4ADRB3, ADRB2
18mitochondrial transportGO:00683910.2UCP1, UCP3

Molecular functions related to Obesity according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1oxidative phosphorylation uncoupler activityGO:01707710.7UCP1, UCP3
2melanocyte-stimulating hormone receptor activityGO:00498010.7MC4R, MC3R
3norepinephrine bindingGO:05138010.7ADRB2, ADRB3
4melanocortin receptor activityGO:00497710.6MC4R, MC3R
5G-protein coupled receptor bindingGO:00166410.5GHRL, POMC
6neuropeptide bindingGO:04292310.5MC3R, MC4R
7hormone activityGO:00517910.5POMC, LEP, PYY
8peptide hormone bindingGO:01704610.2MC4R, MC3R

Products for genes affiliated with Obesity

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Sources for Obesity

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet