MCID: OBS005
MIFTS: 89

Obesity malady

Genetic diseases, Rare diseases, Metabolic diseases categories

Summaries for Obesity

About this section


MedlinePlus:33 Obesity means having too much body fat. it is different from being overweight, which means weighing too much. the weight may come from muscle, bone, fat, and/or body water. both terms mean that a person's weight is greater than what's considered healthy for his or her height. obesity occurs over time when you eat more calories than you use. the balance between calories-in and calories-out differs for each person. factors that might affect your weight include your genetic makeup, overeating, eating high-fat foods, and not being physically active. being obese increases your risk of diabetes, heart disease, stroke, arthritis, and some cancers. if you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases. for example, that means losing 10 to 20 pounds if you weigh 200 pounds. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Obesity is related to insulin resistance and morbid obesity. An important gene associated with Obesity is PYY (peptide YY), and among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. The drugs benzphetamine and phenylpropanolamine hydrochloride and the compounds glucose and lipid have been mentioned in the context of this disorder. Affiliated tissues include liver, ovary and heart, and related mouse phenotypes are adipose tissue and homeostasis/metabolism.

Wikipedia:64 Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a... more...

Descriptions from OMIM:46 601665,607514

Aliases & Classifications for Obesity

About this section

Obesity, Aliases & Descriptions:

Name: Obesity 31 9 42 21 23 46 44 33 61


Classifications:



External Ids:

Disease Ontology9 DOID:9970
MeSH34 D009765
ICD9CM28 278.00
OMIM46 601665
NCIt39 C3283

Related Diseases for Obesity

About this section

Diseases in the Obesity family:

Obesity, Mc4r-Related Obesity, Pparg-Related
Obesity, Susceptibility to, Cartpt-Related Obesity, Susceptibility to, Mc3r-Related
Obesity, Ucp3-Related Obesity, Pyy-Related
Obesity, Sim1-Related Obesity, Early-Onset
Obesity, Late-Onset Obesity, Autosomal Dominant

Diseases related to Obesity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 739)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance33.0ENPP1, PPARG, PYY, LEPR, LEP, MC3R
2morbid obesity32.9PYY, LEPR, LEP, MC3R, MC4R, ADRB3
3diabetes mellitus32.6PPARG, PYY, LEPR, ENPP1, UCP1, UCP3
4hypertension32.5ADRB2, PPARG, LEP, POMC, ADRB3
5polycystic ovary syndrome32.4PPARG, LEPR, GHRL, ADRB3, POMC, LEP
6type 2 diabetes mellitus32.3PPARG, PYY, LEPR, LEP, MC4R, ADRB3
7fatty liver disease32.2ADRB3, LEP, LEPR, PPARG
8glucose intolerance32.2GHRL, ENPP1, ADRB3, LEPR, PPARG, LEP
9eating disorder32.1LEP, PYY, GHRL
10atherosclerosis32.1PPARG, LEPR, LEP, ADRB3, GHRL, ADRB2
11prader-willi syndrome32.0LEP, PYY, GHRL, LEPR
12hyperandrogenism32.0PPARG, POMC, MC4R, LEP
13anorexia nervosa31.9LEP, LEPR, PYY, MC3R, MC4R, POMC
14gestational diabetes31.9LEP, ADRB3, ENPP1, LEPR
15hyperglycemia31.8ENPP1, POMC, LEP, PPARG, LEPR, PYY
16hypogonadism31.8POMC, GHRL, LEP
17hypertriglyceridemia31.8PPARG, ADRB3, LEP
18hyperinsulinism31.8PPARG, LEPR, LEP, MC4R, GHRL
19essential hypertension31.7ADRB3, ADRB2, LEP, LEPR
20breast cancer31.7ADRB3, LEP, PPARG, PYY, LEPR, ENPP1
21cushing's syndrome31.5GHRL, LEP, POMC
22bulimia nervosa31.5PYY, LEPR, LEP, MC4R, GHRL
23type 1 diabetes mellitus31.5LEPR, ENPP1, LEP, ADRB3, ADRB2, UCP1
24lipodystrophy31.5CARTPT, ADRB3, LEP, PPARG
25metabolic syndrome x31.5LEP, PPARG
26arthritis31.4ADRB2, LEP, POMC, GHRL
27growth hormone deficiency31.3LEP, POMC, GHRL
28hypothyroidism31.3GHRL, LEP
29hypopituitarism31.3LEP, POMC, GHRL
30adenoma31.2GHRL, POMC, PPARG, PYY, LEPR
31hypoglycemia31.2ADRB2, POMC, GHRL
32insulinoma31.2GHRL, LEPR, UCP1
33pre-eclampsia31.1ADRB2, LEP, ADRB3, LEPR
34diabetic nephropathy31.0ENPP1, PPARG, ADRB3, UCP1
35anovulation31.0GHRL, LEP
36familial partial lipodystrophy30.9PPARG, LEP
37precocious puberty30.9POMC, LEP
38chronic obstructive pulmonary disease30.9UCP3, ADRB2, LEPR
39amenorrhea30.7LEP, POMC
40acromegaly30.7GHRL, POMC, LEP, LEPR
41pheochromocytoma30.6ADRB2, PYY, POMC, UCP1
42adrenal gland hyperfunction30.6POMC, GHRL, LEP
43acth deficiency30.5POMC, MC4R
44liver disease10.8
45hepatitis10.8
46pituitary adenoma10.7GHRL, LEP, PPARG, POMC, LEPR
47pituitary tumors10.7PPARG, POMC, LEPR, GHRL
48familial hyperlipidemia10.7UCP3, PPARG, ADRB3, UCP1, LEP
49non-suppurative otitis media10.7MC4R, GHRL, LEP
50chronic kidney failure10.7GHRL, LEP, LEPR, ENPP1

Graphical network of the top 20 diseases related to Obesity:



Diseases related to obesity

Symptoms for Obesity

About this section


Clinical features from OMIM:

601665,607514

Drugs & Therapeutics for Obesity

About this section

Genetic Tests for Obesity

About this section

Genetic tests related to Obesity:

id Genetic test Affiliating Genes
1 Obesity21 23

Anatomical Context for Obesity

About this section

MalaCards organs/tissues related to Obesity:

32
Liver, Ovary, Heart, Adipocyte, Skeletal muscle, Bone, Kidney, Endothelial, Breast, Testes, Thyroid, Brain, Prostate, Pituitary, Monocytes, T cells, Colon, Skin, Lung, Hypothalamus, B cells, Pancreatic islet, Pancreas, Spinal cord, Myeloid, Neutrophil, Salivary gland, Bone marrow, Lymph node, Smooth muscle, Small intestine, Placenta, Testis, Amygdala, Eye, Whole blood, Spleen, Thymus, Cortex, Cerebellum, Retina, Nk cells, Pons, Tongue, Adrenal cortex

Animal Models for Obesity or affiliated genes

About this section

Publications for Obesity

About this section

Articles related to Obesity:

(show top 50)    (show all 8960)
idTitleAuthorsYear
1
Perceived weight in youths and risk of overweight or obesity six years later. (24360137)
2014
2
MicroRNA Functions in Brite/Brown Fat - Novel Perspectives towards Anti-Obesity Strategies. (25408843)
2014
3
Body Mass Index Categories and Mortality Risk in US Adults: The Effect of Overweight and Obesity on Advancing Death. (24432921)
2014
4
Substantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder. (23639407)
2013
5
Family Structure and Childhood Obesity: An Analysis Through 8th Grade. (24370680)
2013
6
Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children. (23510779)
2013
7
Influence of attention-deficit/hyperactivity disorder on binge eating behaviors and psychiatric comorbidity profile of obese women. (24246603)
2013
8
Surgically induced interpregnancy weight loss and prevalence of overweight and obesity in offspring. (24349234)
2013
9
Cystic fibrosis: from protein-energy malnutrition to obesity with dyslipidemia. (24800027)
2013
10
Uncoupling protein-2 45-base pair insertion/deletion polymorphism: is there an association with severe obesity and weight loss in morbidly obese subjects? (22568573)
2012
11
Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China. (21892197)
2011
12
GPR43: an emerging target for the potential treatment of type 2 diabetes, obesity and insulin resistance. (20336586)
2010
13
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
14
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch. (20492663)
2010
15
Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes. (19558533)
2010
16
Hypothalamic obesity complicated by adipsic central diabetes insipidus following surgical resection of a craniopharyngioma. (19817945)
2009
17
Obesity and polycystic ovary syndrome. (20054201)
2009
18
Evaluation of bone disease in morbidly obese women after gastric bypass and risk factors implicated in bone loss. (19412643)
2009
19
Obesity alters cytokine gene expression and promotes liver injury in rats with acute pancreatitis. (18223607)
2008
20
The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. (18295974)
2008
21
Metabolic effects of weight loss on a very-low-carbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects. (18174038)
2008
22
Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) study. (18452784)
2008
23
The preservation of insulin sensitivity in obese women without diabetes. (18672628)
2008
24
Novel melanocortin 4 receptor gene mutations in severely obese children. (17941900)
2008
25
Fibrinogen, plasma viscosity and blood viscosity in obesity. Relationship with insulin resistance. (17942983)
2007
26
Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in utah. (16741266)
2006
27
Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. (17065359)
2006
28
Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome. (16077717)
2005
29
Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. (15975705)
2005
30
Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance. (16182246)
2005
31
Superior mesenteric artery syndrome after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (15329194)
2004
32
Addition of rosiglitazone to metformin is most effective in obese, insulin-resistant patients with type 2 diabetes. (12681023)
2003
33
Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses. (12960083)
2003
34
Weight loss in a patient with morbid obesity under treatment with oleoyl-estrone]. (14588193)
2003
35
Central and peripheral glucocorticoid receptor function in abdominal obesity. (11936464)
2002
36
Resistin, obesity and insulin resistance--the emerging role of the adipocyte as an endocrine organ. (11794158)
2001
37
Overweight/obesity, smoking, and heavy alcohol consumption are important determinants of plasma PAI-1 levels in healthy men. (11465242)
2001
38
Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women. (11157312)
2001
39
A cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats. (10958832)
2000
40
Effect of opioid blockade on insulin and growth hormone (GH) secretion in patients with polycystic ovary syndrome: the heterogeneity of impaired GH secretion is related to both obesity and hyperinsulinism. (9935127)
1999
41
The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk. (9569171)
1998
42
A case of acanthosis nigricans in obese siblings with a pedigree of familial polyposis coli. (9330076)
1997
43
The beta(3)-adrenergic receptor TRP64ARG polymorphism and obesity in Alaskan Eskimos. (9426386)
1997
44
Determinants of the kinetics of very low-density lipoprotein apolipoprotein B-100 in non-obese men. (9269527)
1997
45
Pseudotumor cerebri in a patient with Bartter's syndrome and obesity. (8903869)
1996
46
Lipoprotein lipase gene polymorphisms: associations with hypertriglyceridemia and body mass index in obese people. (7627251)
1995
47
Hormones and obesity. (7980347)
1994
48
Arginine potentiates but does not restore the blunted growth hormone response to growth hormone-releasing hormone in obesity. (1588839)
1992
49
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. (1955512)
1991
50
Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats. (1939742)
1991

Variations for Obesity

About this section

UniProtKB/Swiss-Prot genetic disease variations for Obesity:

63 (show all 30)
id Symbol AA change Variation ID SNP ID
1MC4Rp.Ser30ArgVAR_010704
2MC4Rp.Asp37ValVAR_010705rs13447325
3MC4Rp.Pro78LeuVAR_010706rs13447326
4MC4Rp.Arg165TrpVAR_010709rs13447332
5MC4Rp.Gly252SerVAR_010711rs13447336
6MC4Rp.Ile317ThrVAR_010712rs13447337
7MC4Rp.Asn274SerVAR_015357
8MC4Rp.Thr11AlaVAR_038632
9MC4Rp.Ser36TyrVAR_038633
10MC4Rp.Val50MetVAR_038634
11MC4Rp.Ser58CysVAR_038635
12MC4Rp.Asn62SerVAR_038636
13MC4Rp.Asn97AspVAR_038638
14MC4Rp.Ile102SerVAR_038639
15MC4Rp.Ile102ThrVAR_038640
16MC4Rp.Leu106ProVAR_038641
17MC4Rp.Ile125LysVAR_038642
18MC4Rp.Ser127LeuVAR_038643rs13447331
19MC4Rp.Arg165GlnVAR_038644rs13447332
20MC4Rp.Ile170ValVAR_038645rs121913560
21MC4Rp.Ala175ThrVAR_038646
22MC4Rp.Gly181AspVAR_038647rs13447333
23MC4Rp.Ala219ValVAR_038648
24MC4Rp.Val253IleVAR_038650rs187152753
25MC4Rp.Cys271ArgVAR_038651
26MC4Rp.Cys271TyrVAR_038652
27MC4Rp.Ile316SerVAR_038653
28MC4Rp.Leu325PheVAR_038654
29PPARGp.Pro113GlnVAR_010724rs1800571
30UCP3p.Val102IleVAR_004408rs2229707

Clinvar genetic disease variations for Obesity:

7 (show all 40)
id Gene Name Type Significance SNP ID Assembly Location
1ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
2ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
3ENPP1NM_006208.2(ENPP1): c.*1043A> Gsingle nucleotide variantrisk factorrs7754561GRCh37Chr 6, 132212694: 132212694
4MC4RMC4R, 4-BP DEL, NT631deletionPathogenic
5MC4RMC4R, 4-BP INS, NT732insertionPathogenic
6MC4RNM_005912.2(MC4R): c.105C> A (p.Tyr35Ter)single nucleotide variantPathogenicrs13447324GRCh37Chr 18, 58039478: 58039478
7MC4RNM_005912.2(MC4R): c.110A> T (p.Asp37Val)single nucleotide variantPathogenicrs13447325GRCh37Chr 18, 58039473: 58039473
8MC4RNM_005912.2(MC4R): c.148G> A (p.Val50Met)single nucleotide variantPathogenicrs121913557GRCh37Chr 18, 58039435: 58039435
9MC4RNM_005912.2(MC4R): c.172A> T (p.Ser58Cys)single nucleotide variantPathogenicrs121913558GRCh37Chr 18, 58039411: 58039411
10MC4RNM_005912.2(MC4R): c.305T> G (p.Ile102Ser)single nucleotide variantPathogenicrs121913559GRCh37Chr 18, 58039278: 58039278
11MC4RNM_005912.2(MC4R): c.508A> G (p.Ile170Val)single nucleotide variantPathogenicrs121913560GRCh37Chr 18, 58039075: 58039075
12MC4RNM_005912.2(MC4R): c.821A> G (p.Asn274Ser)single nucleotide variantPathogenicrs121913561GRCh37Chr 18, 58038762: 58038762
13MC4RMC4R, 1-BP INS, 112AinsertionPathogenic
14MC4RMC4R, 4-BP DEL, 211CTCTdeletionPathogenic
15MC4RMC4R, 2-BP INS, 279GTinsertionPathogenic
16MC4RMC4R, ILE125LYSundetermined variantPathogenic
17MC4RNM_005912.2(MC4R): c.812G> A (p.Cys271Tyr)single nucleotide variantPathogenicrs121913562GRCh37Chr 18, 58038771: 58038771
18MC4RNM_005912.2(MC4R): c.523G> A (p.Ala175Thr)single nucleotide variantPathogenicrs121913563GRCh37Chr 18, 58039060: 58039060
19MC4RNM_005912.2(MC4R): c.947T> G (p.Ile316Ser)single nucleotide variantPathogenicrs121913564GRCh37Chr 18, 58038636: 58038636
20MC4RNM_005912.2(MC4R): c.861T> A (p.Tyr287Ter)single nucleotide variantPathogenicrs121917829GRCh37Chr 18, 58038722: 58038722
21MC4RNM_005912.2(MC4R): c.289A> G (p.Asn97Asp)single nucleotide variantPathogenicrs121913565GRCh37Chr 18, 58039294: 58039294
22MC4RNM_005912.2(MC4R): c.185A> G (p.Asn62Ser)single nucleotide variantPathogenicrs121913566GRCh37Chr 18, 58039398: 58039398
23MC4RMC4R, 15-BP DELdeletionPathogenic
24MC4RNM_005912.2(MC4R): c.380C> T (p.Ser127Leu)single nucleotide variantPathogenicrs13447331GRCh37Chr 18, 58039203: 58039203
25MC4RMC4R, 2-BP DEL, 750GAdeletionPathogenic
26MC4RNM_005912.2(MC4R): c.656C> T (p.Ala219Val)single nucleotide variantPathogenicrs121913567GRCh37Chr 18, 58038927: 58038927
27ADRB3NM_000025.2(ADRB3): c.190T> C (p.Trp64Arg)single nucleotide variantrisk factorrs4994GRCh37Chr 8, 37823798: 37823798
28ADRB2NM_000024.5(ADRB2): c.79C> G (p.Gln27Glu)single nucleotide variantrisk factorrs1042714GRCh37Chr 5, 148206473: 148206473
29FFAR4NM_181745.3(FFAR4): c.809G> A (p.Arg270His)single nucleotide variantrisk factorrs116454156GRCh37Chr 10, 95347041: 95347041
30LEPRNM_002303.5(LEPR): c.2880C> G (p.Asn960Lys)single nucleotide variantLikely pathogenicrs193922650GRCh37Chr 1, 66102080: 66102080
31MC4RNM_005912.2(MC4R): c.538T> C (p.Ser180Pro)single nucleotide variantLikely pathogenicrs193922685GRCh37Chr 18, 58039045: 58039045
32MC4RNM_005912.2(MC4R): c.806T> A (p.Ile269Asn)single nucleotide variantLikely pathogenicrs79783591GRCh37Chr 18, 58038777: 58038777
33MC4RNM_005912.2(MC4R): c.835_836dupTG (p.Phe280Alafs)duplicationPathogenicrs193922687GRCh37Chr 18, 58038746: 58038747
34MC4RNM_005912.2(MC4R): c.896C> A (p.Pro299His)single nucleotide variantPathogenicrs52804924GRCh37Chr 18, 58038687: 58038687
35NM_001134944.1(GHRL): c.116G> A (p.Arg39Gln)single nucleotide variantrisk factorrs34911341GRCh37Chr 3, 10331519: 10331519
36NM_001134944.1(GHRL): c.233A> T (p.Gln78Leu)single nucleotide variantrisk factorrs4684677GRCh37Chr 3, 10328453: 10328453
37MRAP2NM_138409.2(MRAP2): c.70G> T (p.Glu24Ter)single nucleotide variantrisk factorGRCh37Chr 6, 84765107: 84765107
38CARTPTNM_004291.3(CARTPT): c.183G> C (p.Leu61Phe)single nucleotide variantrisk factorrs121909065GRCh37Chr 5, 71015730: 71015730
39PYYNM_004160.4(PYY): c.185A> C (p.Gln62Pro)single nucleotide variantrisk factorrs267606994GRCh37Chr 17, 42030667: 42030667
40MT-CYBm.15497G> Asingle nucleotide variantrisk factorrs199951903GRCh37Chr MT, 15497: 15497

Expression for genes affiliated with Obesity

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Obesity patients vs. healthy controls: 31 (show all 314)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1TYROBPTYRO protein tyrosine kinase binding proteinAdipose+4.220.000
2SLNsarcolipinSkeletal Muscle-4.170.031
3GAPDHglyceraldehyde-3-phosphate dehydrogenaseSkeletal Muscle-4.140.045
4GPR183G protein-coupled receptor 183Adipose+3.950.000
5FN1fibronectin 1Adipose+3.760.000
6AZGP1alpha-2-glycoprotein 1, zinc-bindingAdipose-3.650.000
7RPL41ribosomal protein L41Skeletal Muscle-3.560.040
8TIMP1TIMP metallopeptidase inhibitor 1Adipose+3.530.000
9CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 9Liver-3.460.001
10PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 1Adipose+3.440.000
11PTGDSprostaglandin D2 synthase 21kDa (brain)Adipose+3.420.000
12LYZlysozymeAdipose+3.330.000
13MFAP5microfibrillar associated protein 5Adipose+3.260.003
14SNCAsynuclein, alpha (non A4 component of amyloid precursor)Blood+3.150.000
15SPP1secreted phosphoprotein 1Adipose+3.060.000
16ZFP36L2ZFP36 ring finger protein-like 2Liver+3.030.012
17TTNtitinSkeletal Muscle-3.030.043
18HUWE1HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligaseSkeletal Muscle-2.990.048
19NUDT4nudix (nucleoside diphosphate linked moiety X)-type motif 4Liver-2.970.006
20NDUFA2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDaLiver-2.960.003
21COL11A1collagen, type XI, alpha 1Adipose+2.950.001
22TPSAB1tryptase alpha/beta 1Liver+2.900.003
23IGJimmunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptidesAdipose+2.890.010
24GPM6Bglycoprotein M6BLiver-2.890.018
25ABHD6abhydrolase domain containing 6Liver-2.880.002
26IGLimmunoglobulin lambda locusAdipose+2.870.004
27TYMPthymidine phosphorylaseAdipose+2.870.000
28CALM1calmodulin 1 (phosphorylase kinase, delta)Liver-2.860.000
29UBCubiquitin CSkeletal Muscle-2.850.048
30PRMT3protein arginine methyltransferase 3Liver-2.850.006
31MSR1macrophage scavenger receptor 1Adipose+2.840.000
32IGFBP1insulin-like growth factor binding protein 1Liver-2.820.025
33KIAA0754KIAA0754Liver-2.790.012
34IL17RCinterleukin 17 receptor CLiver+2.760.007
35FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)Adipose+2.750.009
36MVKmevalonate kinaseLiver+2.730.005
37IL8interleukin 8Adipose+2.720.001
38RPL23Aribosomal protein L23aSkeletal Muscle-2.710.028
39IGHMimmunoglobulin heavy constant muLiver+2.700.030
40METTL5methyltransferase like 5Liver-2.690.034
41STMN2stathmin 2Adipose+2.650.001
42PRICKLE3prickle homolog 3 (Drosophila)Liver+2.650.013
43FGF18fibroblast growth factor 18Liver+2.640.019
44CLEC4EC-type lectin domain family 4, member ELiver+2.640.014
45PHLDA2pleckstrin homology-like domain, family A, member 2Adipose+2.640.003
46GOLPH3Lgolgi phosphoprotein 3-likeLiver-2.640.010
47CA3carbonic anhydrase III, muscle specificAdipose-2.630.010
48GREB1growth regulation by estrogen in breast cancer 1Liver-2.630.032
49SP100SP100 nuclear antigenLiver-2.620.021
50MCF2MCF.2 cell line derived transforming sequenceLiver-2.620.036
51LCP1lymphocyte cytosolic protein 1 (L-plastin)Adipose+2.610.001
52ABCC3ATP-binding cassette, sub-family C (CFTR/MRP), member 3Adipose+2.580.004
53ABCA2ATP-binding cassette, sub-family A (ABC1), member 2Liver+2.570.000
54CA1carbonic anhydrase IBlood+2.570.001
55FGFR4fibroblast growth factor receptor 4Liver+2.570.030
56UGT2B15UDP glucuronosyltransferase 2 family, polypeptide B15Liver-2.560.007
57POU3F3POU class 3 homeobox 3Liver-2.560.026
58BCAP29B-cell receptor-associated protein 29Liver-2.520.012
59IRAK3interleukin-1 receptor-associated kinase 3Liver-2.520.002
60IBSPintegrin-binding sialoproteinLiver+2.510.001
61DKK3dickkopf WNT signaling pathway inhibitor 3Liver-2.510.034
62PSIP1PC4 and SFRS1 interacting protein 1Liver-2.500.003
63WDR1WD repeat domain 1Liver+2.470.024
64THOC6THO complex 6 homolog (Drosophila)Liver+2.470.002
65TNNC2troponin C type 2 (fast)Skeletal Muscle-2.460.044
66MRPL42mitochondrial ribosomal protein L42Liver-2.460.045
67FRZBfrizzled-related proteinAdipose+2.440.013
68ARHGEF26Rho guanine nucleotide exchange factor (GEF) 26Liver-2.430.040
69YIPF2Yip1 domain family, member 2Liver+2.420.037
70TMCO3transmembrane and coiled-coil domains 3Liver+2.420.016
71HLA-DQB1major histocompatibility complex, class II, DQ beta 1Liver-2.410.014
72HOXC8homeobox C8Liver+2.410.001
73F2Rcoagulation factor II (thrombin) receptorAdipose+2.400.008
74PRSS23protease, serine, 23Adipose+2.370.000
75IL1Binterleukin 1, betaAdipose+2.370.000
76MYOTmyotilinLiver-2.370.046
77PPP1R3Aprotein phosphatase 1, regulatory subunit 3ALiver-2.370.040
78DLX5distal-less homeobox 5Liver-2.360.050
79CDK10cyclin-dependent kinase 10Liver+2.360.011
80TRIM15tripartite motif containing 15Liver+2.350.005
81NINJ2ninjurin 2Liver-2.350.033
82ANGPT2angiopoietin 2Adipose+2.340.002
83C6orf62chromosome 6 open reading frame 62Liver-2.340.001
84MCOLN1mucolipin 1Liver+2.330.006
85CHRNA4cholinergic receptor, nicotinic, alpha 4 (neuronal)Liver+2.330.044
86ARIH2ariadne RBR E3 ubiquitin protein ligase 2Liver+2.330.049
87NMT1N-myristoyltransferase 1Liver+2.320.038
88ARPC4actin related protein 2/3 complex, subunit 4, 20kDaLiver+2.310.008
89IGFBP6insulin-like growth factor binding protein 6Adipose+2.300.030
90PSG5pregnancy specific beta-1-glycoprotein 5Liver-2.300.037
91CNGB1cyclic nucleotide gated channel beta 1Liver-2.290.021
92HTR1B5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupledLiver-2.290.028
93DESdesminLiver-2.280.025
94DHPSdeoxyhypusine synthaseLiver+2.270.033
95EMP3epithelial membrane protein 3Adipose+2.270.014
96BAXBCL2-associated X proteinLiver+2.260.009
97DNAH9dynein, axonemal, heavy chain 9Liver+2.250.005
98PRPF4pre-mRNA processing factor 4Liver+2.250.011
99FASTKFas-activated serine/threonine kinaseLiver+2.250.019
100TRIM10tripartite motif containing 10Blood+2.250.001
101PPP4Cprotein phosphatase 4, catalytic subunitLiver+2.240.017
102TFDP2transcription factor Dp-2 (E2F dimerization partner 2)Liver+2.240.043
103RBM19RNA binding motif protein 19Liver+2.240.001
104F13A1coagulation factor XIII, A1 polypeptideAdipose+2.230.001
105CTGFconnective tissue growth factorAdipose+2.230.000
106VCANversicanAdipose+2.230.012
107ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)Adipose+2.230.005
108TNFSF4tumor necrosis factor (ligand) superfamily, member 4Liver-2.230.026
109EFCAB11EF-hand calcium binding domain 11Liver+2.230.041
110PEX1peroxisomal biogenesis factor 1Adipose-2.210.004
111PTX3pentraxin 3, longAdipose+2.210.003
112GNASGNAS complex locusLiver+2.200.015
113SERPINB4serpin peptidase inhibitor, clade B (ovalbumin), member 4Liver-2.200.048
114KIFC3kinesin family member C3Liver+2.200.011
115QTRT1queuine tRNA-ribosyltransferase 1Liver+2.190.049
116NOL8nucleolar protein 8Liver-2.180.038
117TMEM121transmembrane protein 121Liver+2.180.003
118XKX-linked Kx blood group (McLeod syndrome)Blood+2.180.001
119RRBP1ribosome binding protein 1Liver+2.170.003
120CD14CD14 moleculeAdipose+2.170.003
121INSM1insulinoma-associated 1Liver-2.170.028
122NRIP2nuclear receptor interacting protein 2Liver+2.150.028
123AMDHD2amidohydrolase domain containing 2Liver+2.150.028
124ACTA1actin, alpha 1, skeletal muscleLiver+2.150.028
125DLATdihydrolipoamide S-acetyltransferaseLiver+2.130.009
126HGC6.3uncharacterized LOC100128124Liver+2.130.024
127PTPRCprotein tyrosine phosphatase, receptor type, CAdipose+2.130.000
128HABP4hyaluronan binding protein 4Liver+2.120.019
129PDK2pyruvate dehydrogenase kinase, isozyme 2Liver+2.120.045
130SEMA6Bsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6BLiver+2.110.018
131C1orf56chromosome 1 open reading frame 56Liver-2.110.016
132TMEM194Atransmembrane protein 194ALiver-2.100.020
133IFI30interferon, gamma-inducible protein 30Adipose+2.100.001
134FECHferrochelataseBlood+2.090.003
135RNF41ring finger protein 41, E3 ubiquitin protein ligaseLiver-2.090.000
136CXCL2chemokine (C-X-C motif) ligand 2Adipose+2.080.028
137S100A1S100 calcium binding protein A1Adipose-2.080.012
138GTF2F1general transcription factor IIF, polypeptide 1, 74kDaLiver+2.080.042
139KIF24kinesin family member 24Liver-2.080.045
140CD44CD44 molecule (Indian blood group)Liver+2.080.006
141GGA1golgi-associated, gamma adaptin ear containing, ARF binding protein 1Liver+2.080.014
142OPA3optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)Liver+2.070.031
143NCF4neutrophil cytosolic factor 4, 40kDaLiver+2.070.025
144CRPC-reactive protein, pentraxin-relatedLiver+2.070.037
145TRAM1translocation associated membrane protein 1Liver-2.070.046
146TNPO2transportin 2Liver+2.060.010
147MIAmelanoma inhibitory activityLiver+2.060.025
148ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1Liver-2.060.036
149ZNF460zinc finger protein 460Liver-2.050.039
150WISP1WNT1 inducible signaling pathway protein 1Liver+2.050.012
151CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunitLiver+2.040.044
152CD52CD52 moleculeAdipose+2.040.031
153CXorf56chromosome X open reading frame 56Liver-2.030.046
154HLA-DPB1major histocompatibility complex, class II, DP beta 1Adipose+2.020.005
155COL6A2collagen, type VI, alpha 2Adipose+2.020.004
156NOTCH3notch 3Adipose+2.010.033
157CHAF1Bchromatin assembly factor 1, subunit B (p60)Skeletal Muscle+2.000.033
158AGKacylglycerol kinaseLiver-2.000.011
159CRCT1cysteine-rich C-terminal 1Liver-2.000.030
160DNAJC6DnaJ (Hsp40) homolog, subfamily C, member 6Liver-2.000.032
161COL1A2collagen, type I, alpha 2Adipose+2.000.008
162GYPBglycophorin B (MNS blood group)Blood+2.000.004
163EPHA3EPH receptor A3Liver-1.990.025
164BCANbrevicanLiver+1.990.019
165COX7Bcytochrome c oxidase subunit VIIbBlood+1.980.002
166AHSPalpha hemoglobin stabilizing proteinBlood+1.980.012
167TPM2tropomyosin 2 (beta)Adipose+1.980.000
168BTBD2BTB (POZ) domain containing 2Liver+1.980.032
169IL1RNinterleukin 1 receptor antagonistAdipose+1.980.016
170RHOT2ras homolog family member T2Liver+1.970.036
171PALLDpalladin, cytoskeletal associated proteinAdipose+1.960.006
172TBXA2Rthromboxane A2 receptorLiver+1.960.041
173FTLferritin, light polypeptideAdipose-1.950.011
174YIPF6Yip1 domain family, member 6Blood+1.950.001
175ZFP30ZFP30 zinc finger proteinLiver-1.940.043
176LIG3ligase III, DNA, ATP-dependentLiver+1.940.017
177DHRS2dehydrogenase/reductase (SDR family) member 2Liver+1.930.023
178BBS4Bardet-Biedl syndrome 4Liver-1.930.019
179PLEKHB2pleckstrin homology domain containing, family B (evectins) member 2Liver+1.930.024
180TNFRSF11Btumor necrosis factor receptor superfamily, member 11bAdipose+1.930.025
181MAGOH2mago-nashi homolog 2 (pseudogene)Liver-1.930.024
182DPYSL3dihydropyrimidinase-like 3Adipose+1.920.047
183KLF13Kruppel-like factor 13Liver+1.920.044
184NRXN2neurexin 2Liver+1.920.043
185HMOX1heme oxygenase (decycling) 1Adipose+1.920.002
186SLASrc-like-adaptorLiver+1.920.029
187BPGM2,3-bisphosphoglycerate mutaseBlood+1.910.006
188ALDH1A3aldehyde dehydrogenase 1 family, member A3Adipose+1.910.001
189ESRRAestrogen-related receptor alphaLiver+1.910.031
190CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 8Liver-1.910.049
191CAPZA2capping protein (actin filament) muscle Z-line, alpha 2Blood+1.910.024
192FEZ1fasciculation and elongation protein zeta 1 (zygin I)Adipose+1.900.017
193DAPK2death-associated protein kinase 2Liver+1.900.040
194TXNthioredoxinLiver-1.900.019
195ZNF783zinc finger family member 783Liver+1.890.021
196C1QBcomplement component 1, q subcomponent, B chainAdipose+1.890.026
197FGF1fibroblast growth factor 1 (acidic)Adipose+1.890.020
198NUP210nucleoporin 210kDaLiver+1.880.031
199SESN3sestrin 3Blood+1.880.002
200SYNJ2synaptojanin 2Liver+1.880.027
201PPP1R12Aprotein phosphatase 1, regulatory subunit 12ALiver+1.880.046
202APOBRapolipoprotein B receptorLiver+1.870.009
203STARD3StAR-related lipid transfer (START) domain containing 3Liver+1.870.025
204RUNX1runt-related transcription factor 1Liver+1.860.046
205CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Adipose+1.860.040
206STRNstriatin, calmodulin binding proteinAdipose-1.860.004
207NSFL1CNSFL1 (p97) cofactor (p47)Liver+1.860.030
208CD53CD53 moleculeAdipose+1.850.027
209GYPEglycophorin E (MNS blood group)Blood+1.840.011
210SIPA1signal-induced proliferation-associated 1Liver+1.840.049
211ARF6ADP-ribosylation factor 6Liver+1.840.013
212BIRC5baculoviral IAP repeat containing 5Liver-1.840.028
213RASSF2Ras association (RalGDS/AF-6) domain family member 2Adipose+1.830.014
214CALYcalcyon neuron-specific vesicular proteinLiver-1.820.042
215HRASHarvey rat sarcoma viral oncogene homologAdipose+1.810.005
216GNA11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)Liver+1.810.021
217PYGMphosphorylase, glycogen, muscleAdipose-1.810.030
218MID1midline 1 (Opitz/BBB syndrome)Liver-1.810.020
219SCML1sex comb on midleg-like 1 (Drosophila)Liver-1.800.031
220MFAP4microfibrillar-associated protein 4Adipose+1.800.030
221MALLmal, T-cell differentiation protein-likeAdipose+1.800.025
222RSL24D1ribosomal L24 domain containing 1Blood+1.790.015
223HEMGNhemogenBlood+1.790.010
224GMFBglia maturation factor, betaBlood+1.780.007
225ABCC13ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogeneBlood+1.770.035
226SOX6SRY (sex determining region Y)-box 6Blood+1.770.002
227SNX16sorting nexin 16Blood+1.770.020
228KIAA0141KIAA0141Liver+1.770.005
229ATP5G2ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)Liver+1.760.047
230GAS2growth arrest-specific 2Liver-1.760.016
231JUNjun proto-oncogeneLiver-1.760.013
232DNAJC6DnaJ (Hsp40) homolog, subfamily C, member 6Blood+1.760.007
233UBE2Wubiquitin-conjugating enzyme E2W (putative)Blood+1.760.012
234SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesinBlood-1.760.044
235PROS1protein S (alpha)Blood+1.750.024
236PTPRCprotein tyrosine phosphatase, receptor type, CLiver+1.740.029
237GIPC2GIPC PDZ domain containing family, member 2Liver-1.730.028
238MXRA5matrix-remodelling associated 5Adipose+1.730.049
239ZYXzyxinAdipose+1.730.020
240S100A4S100 calcium binding protein A4Adipose+1.720.007
241CCL3chemokine (C-C motif) ligand 3Adipose+1.720.011
242WISP2WNT1 inducible signaling pathway protein 2Adipose+1.720.036
243TGFB1transforming growth factor, beta 1Liver+1.720.028
244LEPRleptin receptorLiver-1.720.047
245IRS2insulin receptor substrate 2Liver-1.710.038
246KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 1Liver+1.710.040
247PFKPphosphofructokinase, plateletAdipose+1.710.025
248TMEM50Btransmembrane protein 50BBlood+1.710.010
249CCDC176coiled-coil domain containing 176Blood+1.700.024
250MTMR1myotubularin related protein 1Liver+1.700.032
251GPNMBglycoprotein (transmembrane) nmbAdipose+1.700.038
252BCL2A1BCL2-related protein A1Blood+1.700.020
253ACTA2actin, alpha 2, smooth muscle, aortaAdipose+1.700.010
254ARGLU1arginine and glutamate rich 1Blood+1.690.029
255SLC14A1solute carrier family 14 (urea transporter), member 1 (Kidd blood group)Blood+1.690.025
256FZD9frizzled class receptor 9Liver-1.680.025
257MICU2mitochondrial calcium uptake 2Liver-1.680.029
258RPS27Lribosomal protein S27-likeBlood+1.680.013
259FGFR1OP2FGFR1 oncogene partner 2Blood+1.670.012
260SRGNserglycinAdipose+1.670.035
261TAGLNtransgelinAdipose+1.660.010
262TTC33tetratricopeptide repeat domain 33Blood+1.660.029
263MED21mediator complex subunit 21Blood+1.660.015
264RPL31ribosomal protein L31Blood+1.650.010
265TSPAN5tetraspanin 5Blood+1.650.032
266LY96lymphocyte antigen 96Blood+1.650.009
267RAB11ARAB11A, member RAS oncogene familyBlood+1.640.037
268COX7Ccytochrome c oxidase subunit VIIcBlood+1.640.017
269CRISP3cysteine-rich secretory protein 3Blood+1.640.035
270SELTselenoprotein TBlood+1.640.036
271FMO3flavin containing monooxygenase 3Adipose+1.610.042
272ANXA3annexin A3Blood+1.610.013
273HTR45-hydroxytryptamine (serotonin) receptor 4, G protein-coupledLiver+1.610.023
274RPL34ribosomal protein L34Blood+1.600.026
275ST3GAL6ST3 beta-galactoside alpha-2,3-sialyltransferase 6Adipose-1.590.048
276SUB1SUB1 homolog (S. cerevisiae)Blood+1.590.028
277ZDHHC21zinc finger, DHHC-type containing 21Blood+1.590.042
278ACTR6ARP6 actin-related protein 6 homolog (yeast)Blood+1.580.050
279LAPTM5lysosomal protein transmembrane 5Adipose+1.580.007
280MMP8matrix metallopeptidase 8 (neutrophil collagenase)Blood+1.570.020
281CASD1CAS1 domain containing 1Blood+1.570.034
282LOC643634tropomyosin 1 (alpha) pseudogeneAdipose+1.570.021
283RPL36Aribosomal protein L36aBlood+1.560.029
284COL3A1collagen, type III, alpha 1Adipose+1.560.006
285PRKCIprotein kinase C, iotaBlood+1.560.037
286ACACBacetyl-CoA carboxylase betaAdipose-1.550.010
287NRIP1nuclear receptor interacting protein 1Blood+1.550.048
288DSC2desmocollin 2Blood+1.550.015
289TNMDtenomodulinLiver-1.550.033
290GYPAglycophorin A (MNS blood group)Blood+1.540.039
291VSIG4V-set and immunoglobulin domain containing 4Adipose+1.540.045
292HNMThistamine N-methyltransferaseBlood+1.530.039
293FCHO2FCH domain only 2Blood+1.530.045
294YOD1YOD1 deubiquitinaseBlood+1.530.031
295TMCO1transmembrane and coiled-coil domains 1Blood+1.530.022
296RBX1ring-box 1, E3 ubiquitin protein ligaseBlood+1.520.013
297C1Rcomplement component 1, r subcomponentAdipose+1.520.026
298DMDdystrophinLiver-1.520.047
299SDC4syndecan 4Liver+1.520.047
300RPS7ribosomal protein S7Blood+1.510.045
301TUBB2Atubulin, beta 2A class IIaAdipose+1.500.033
302KAT2BK(lysine) acetyltransferase 2BBlood+1.490.027
303N4BP2NEDD4 binding protein 2Blood+1.480.048
304TMED3transmembrane emp24 protein transport domain containing 3Adipose+1.480.036
305MIB1mindbomb E3 ubiquitin protein ligase 1Blood+1.480.037
306MBNL3muscleblind-like splicing regulator 3Blood+1.460.015
307RPS17ribosomal protein S17Blood+1.460.037
308ZNHIT3zinc finger, HIT-type containing 3Blood+1.450.033
309PGM2phosphoglucomutase 2Blood+1.450.035
310CD44CD44 molecule (Indian blood group)Adipose+1.430.017
311RAB2BRAB2B, member RAS oncogene familyBlood+1.430.045
312CD58CD58 moleculeBlood+1.430.046
313SMAD2SMAD family member 2Blood+1.380.047
314RND3Rho family GTPase 3Adipose+1.380.023

Expression patterns in normal tissues for genes affiliated with Obesity

Search GEO for disease gene expression data for Obesity.

Pathways for genes affiliated with Obesity

About this section

Pathways related to Obesity according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.9LEPR, GHRL, ADRB2, ADRB3, POMC, MC4R
2
Show member pathways
10.9PYY, GHRL, LEPR, FFAR4, LEP, POMC
3
Show member pathways
10.7UCP1, PPARG, LEPR, MT-CYB, LEP, UCP3
4
Show member pathways
10.7ADRB3, UCP1, ADRB2, POMC, PPARG
510.7ADRB3, ADRB2, POMC, MC4R, MC3R
6
Show member pathways
10.6LEP, FFAR4, POMC, GHRL
710.6PPARG, LEP, UCP1
8
Show member pathways
10.6LEPR, POMC, LEP
910.6POMC, LEP, LEPR
1010.6PYY, ADRB2
11
Show member pathways
10.6UCP1, UCP3
12
Show member pathways
10.6FFAR4, LEP
1310.6POMC, MC4R

Compounds for genes affiliated with Obesity

About this section

Compounds related to Obesity according to GeneCards/GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1glucose4411.5UCP1, ADRB3, PYY, LEPR, LEP, ENPP1
2lipid4411.5MT-CYB, ADRB2, ADRB3, MC4R, MC3R, LEP
3fatty acid4411.3LEP, GHRL, LEPR, PYY, UCP3, PPARG
4cocaine44 1212.3CARTPT, LEP, GHRL, ADRB2, POMC, PYY
5cholesterol44 29 25 1214.3PYY, UCP1, PPARG, ADRB3, GHRL, UCP3
6alanine4411.3ADRB3, PPARG, LEPR, MC4R, POMC, ADRB2
7norepinephrine44 25 1213.3PYY, LEP, ADRB3, ADRB2, GHRL, UCP3
8estrogen4411.2PPARG, PYY, LEPR, LEP, POMC, UCP3
9cyclic amp44 2512.2MC3R, ADRB3, ADRB2, GHRL, CARTPT, UCP1
10dopamine44 29 25 1214.2MC3R, LEPR, PYY, POMC, ADRB2, GHRL
11acth4411.2MC4R, MC3R, GHRL, POMC, LEPR, PYY
12gnrh4411.2ADRB2, GHRL, POMC, MC3R, LEP, PYY
13dexamethasone44 50 29 1214.2GHRL, PPARG, ADRB2, ADRB3, POMC, LEPR
14arginine4411.2GHRL, POMC, ADRB2, MC4R, PYY, LEPR
15nitric oxide44 25 1213.2UCP1, ADRB2, GHRL, LEPR, MC4R, ADRB3
16triiodothyronine4411.2LEPR, POMC, UCP1, UCP3, GHRL, LEP
17clozapine44 29 50 1214.2MC4R, GHRL, ADRB2, ADRB3, POMC, LEP
18corticosterone44 60 2513.1LEPR, MC3R, MC4R, POMC, GHRL, LEP
19serine4411.1UCP1, MT-CYB, ADRB2, POMC, LEP, LEPR
20thyroxine44 2512.1GHRL, LEP, PPARG, LEPR, UCP1, POMC
21amphetamine44 50 1213.1POMC, GHRL, CARTPT, PYY, MC4R
222-deoxyglucose44 1212.1POMC, PPARG, GHRL, PYY, UCP3
23c-peptide4411.1PYY, LEP, ADRB3, GHRL, UCP1
24metformin44 50 1213.1GHRL, PPARG, POMC, LEP, ENPP1
25testosterone44 60 25 1214.1UCP1, ADRB2, PPARG, LEPR, GHRL, LEP
26shu 911960 4412.1MC4R, MC3R, POMC, LEP
27olanzapine44 50 29 25 1215.1LEP, MC4R, ADRB3, GHRL, LEPR
28alpha msh4411.0LEP, MC3R, MC4R, POMC
29intralipid4411.0UCP3, GHRL, LEP, PYY
30orlistat44 60 1213.0PPARG, GHRL, LEP, PYY
31vegf4411.0GHRL, UCP3, ADRB2, POMC, PPARG, LEP
32rosiglitazone29 44 50 25 1215.0PPARG, LEP, GHRL, UCP3, UCP1
33hydrogen44 2512.0UCP1, UCP3, PYY, GHRL, MT-CYB, ADRB2
34thiazolidinedione4411.0PPARG, UCP1, UCP3, LEP
35[d-trp8]-gamma-msh6010.9MC3R, MC4R, POMC
36naloxone44 29 50 1213.9GHRL, ADRB2, POMC, LEP
37pg 1066010.9MC4R, POMC, MC3R
38alpha-msh60 2911.9MC3R, POMC, MC4R
39hs 0146010.9MC4R, MC3R, POMC
40clenbuterol44 1211.9ADRB3, LEP, ADRB2
41opiate4410.9MC4R, POMC, ADRB2, GHRL
42stavudine44 1211.8PPARG, UCP1, LEP
43gaba4410.8GHRL, ADRB2, PYY, LEP, POMC
44triacylglycerol4410.8LEP, LEPR, PYY, GHRL
45pramlintide44 1211.8LEP, PYY, GHRL
46epinephrine44 25 1212.8GHRL, ADRB3, POMC, ADRB2, LEP
47catecholamine4410.6ADRB3, ADRB2, UCP1, POMC
48acipimox44 2911.6LEP, GHRL, UCP3
49ribonucleic acid4410.6UCP3, GHRL, LEPR, POMC, UCP1
50oxygen44 2511.5ADRB3, LEPR, ADRB2, MT-CYB, GHRL, UCP3

GO Terms for genes affiliated with Obesity

About this section

Cellular components related to Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.6ENPP1, PYY, LEP, POMC, GHRL, CARTPT
2receptor complexGO:04323510.6ADRB2, ADRB3, LEPR
3secretory granule lumenGO:03477410.3GHRL, POMC

Biological processes related to Obesity according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1energy reserve metabolic processGO:00611211.0MRAP2, LEPR, LEP, MC4R, ADRB3
2brown fat cell differentiationGO:05087311.0UCP1, ADRB2, ADRB3, PPARG
3response to coldGO:00940911.0PPARG, ADRB3, ADRB2, UCP3
4adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718811.0ADRB2, ADRB3, MC4R, MC3R
5regulation of blood pressureGO:00821710.9PPARG, LEP, MC3R, POMC
6diet induced thermogenesisGO:00202410.9MC4R, ADRB3, ADRB2
7adult feeding behaviorGO:00834310.9CARTPT, GHRL, LEP
8eating behaviorGO:04275510.9ADRB3, LEP, PYY
9feeding behaviorGO:00763110.9MC4R, PYY, MRAP2
10positive regulation of cAMP biosynthetic processGO:03081910.9MRAP2, MC3R, MC4R
11negative regulation of glucagon secretionGO:07009310.8LEP, CARTPT
12heat generationGO:03164910.8ADRB3, ADRB2
13desensitization of G-protein coupled receptor protein signaling pathway by arrestinGO:00203210.8ADRB3, ADRB2
14response to insulinGO:03286810.8LEP, MC4R, UCP3
15vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:00202510.8ADRB3, ADRB2
16generation of precursor metabolites and energyGO:00609110.8ENPP1, ADRB3, POMC
17positive regulation of MAPK cascadeGO:04341010.8LEP, ADRB3, ADRB2
18negative regulation of appetiteGO:03209910.7CARTPT, LEP
19G-protein coupled receptor signaling pathwayGO:00718610.7PPARG, PYY, GHRL, CARTPT
20adrenergic receptor signaling pathwayGO:07187510.6ADRB2, ADRB3
21adipose tissue developmentGO:06061210.6FTO, LEP
22negative regulation of multicellular organism growthGO:04001510.5ADRB2, ADRB3
23mitochondrial transportGO:00683910.3UCP1, UCP3

Molecular functions related to Obesity according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1oxidative phosphorylation uncoupler activityGO:01707710.8UCP1, UCP3
2melanocyte-stimulating hormone receptor activityGO:00498010.8MC4R, MC3R
3type 1 melanocortin receptor bindingGO:07099610.8POMC, MRAP2
4norepinephrine bindingGO:05138010.7ADRB3, ADRB2
5type 4 melanocortin receptor bindingGO:03178210.7MRAP2, POMC
6type 3 melanocortin receptor bindingGO:03178110.7MRAP2, POMC
7melanocortin receptor activityGO:00497710.6MC4R, MC3R
8neuropeptide bindingGO:04292310.6MC4R, MC3R
9G-protein coupled receptor bindingGO:00166410.6GHRL, POMC
10hormone activityGO:00517910.5PYY, LEP, POMC
11peptide hormone bindingGO:01704610.3MC4R, MC3R

Products for genes affiliated with Obesity

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Obesity

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet