MCID: OBS005
MIFTS: 93

Obesity malady

Metabolic diseases category

Summaries for Obesity

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Obesity means having too much body fat. it is different from being overweight, which means weighing too much. the weight may come from muscle, bone, fat, and/or body water. both terms mean that a person's weight is greater than what's considered healthy for his or her height. obesity occurs over time when you eat more calories than you use. the balance between calories-in and calories-out differs for each person. factors that might affect your weight include your genetic makeup, overeating, eating high-fat foods, and not being physically active. being obese increases your risk of diabetes, heart disease, stroke, arthritis, and some cancers. if you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases. for example, that means losing 10 to 20 pounds if you weigh 200 pounds. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Obesity is related to morbid obesity and hypertension. An important gene associated with Obesity is ADRB2 (adrenoceptor beta 2, surface), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The drugs fenfluramine and fenfluramine hydrochloride and the compounds lipid and glucose have been mentioned in the context of this disorder. Affiliated tissues include liver, ovary and heart, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Wikipedia:63 Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a... more...

Description from OMIM:46 601665,607514

Aliases & Classifications for Obesity

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8Disease Ontology, 42NIH Rare Diseases, 20GeneTests, 22GTR, 46OMIM, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


Aliases & Descriptions:

obesity 8 42 20 22 46 44 33 60


External Ids:

Disease Ontology8 DOID:9970
ICD9CM27 278.00
MeSH34 D009765
NCIt39 C3283
OMIM46 601665

Related Diseases for Obesity

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17GeneCards, 18GeneDecks
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Diseases in the Obesity family:

Obesity, Mc4r-Related Obesity, Pparg-Related
Obesity, Susceptibility to, Cartpt-Related Obesity, Susceptibility to, Mc3r-Related
Obesity, Ucp3-Related Obesity, Pyy-Related
Obesity, Sim1-Related Obesity, Early-Onset
Obesity, Late-Onset

Diseases related to Obesity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 694)
idRelated DiseaseScoreTop Affiliating Genes
1morbid obesity31.6LEPR, LEP, MC3R, MC4R, FTO, GHRL
2hypertension31.4HSD11B1, PPARG, POMC, LEP, ADRB3, ADRB2
3diabetes mellitus31.4LEPR, LEP, MC4R, FTO, POMC, GHRL
4polycystic ovary syndrome31.2ADRB3, LEPR, LEP, POMC, GHRL, PPARG
5type 2 diabetes mellitus31.1HSD11B1, ADRB2, ADRB3, ENPP1, LEPR, LEP
6fatty liver disease31.0UCP2, PPARG, LEP, LEPR, ADRB3
7eating disorder31.0LEP, GHRL, PYY
8glucose intolerance31.0HSD11B1, PPARG, GHRL, LEP, LEPR, ENPP1
9atherosclerosis30.9UCP2, HSD11B1, UCP1, UCP3, PPARG, ADRB2
10prader-willi syndrome30.9PYY, GHSR, GHRL, LEP, LEPR
11breast cancer30.8PYY, PPARG, GHSR, PCSK1, LEP, LEPR
12acanthosis nigricans30.8LEP
13hyperandrogenism30.8PPARG, POMC, MC4R, LEP
14gestational diabetes30.8LEP, LEPR, ENPP1, ADRB3
15asthma30.7ADRB2, POMC, GHRL
16thyroiditis30.7POMC
17anorexia nervosa30.7POMC, GHRL, PYY, MC4R, MC3R, LEP
18hypogonadism30.7GHRL, POMC, PCSK1, LEP
19craniopharyngioma30.6POMC
20prostate cancer30.6PPARG, GHRL, LEPR, ADRB2
21hyperglycemia30.6PPARG, UCP2, PYY, HSD11B1, GHSR, ADRB3
22hyperinsulinism30.6LEPR, LEP, MC4R, GHRL, PPARG
23essential hypertension30.6LEP, LEPR, ADRB3, ADRA2B, ADRB2
24adenocarcinoma30.5ADRB2, GHRL, UCP2, PYY, HSD11B1
25myocardial infarction30.5ADRB2, ADRA2B, ENPP1, GHRL
26cushing's syndrome30.5HSD11B1, GHSR, GHRL, POMC, LEP
27infertility30.4LEP, LEPR
28hypothyroidism30.4GHSR, GHRL, POMC, PCSK1, LEP
29metabolic syndrome x30.4LEP, PPARG, HSD11B1
30coronary artery disease30.4PPARG, GHRL, LEPR, ENPP1, ADRB3, ADRB2
31bulimia nervosa30.4MC4R, GHRL
32colorectal cancer30.3LEPR, GHRL, PPARG
33leukemia30.3LEPR
34lipodystrophy30.3ADRB3, LEP, PPARG, HSD11B1
35arthritis30.3GHRL, POMC, LEP, ADRB2
36hypopituitarism30.2HSD11B1, GHRL, POMC, LEP
37colon cancer30.2LEPR, PPARG, PYY
38alzheimer's disease30.1PYY, UCP2, PPARG, PCSK1, ADRB2
39hypoglycemia30.1ADRB2, POMC, GHRL
40obesity with impaired prohormone processing30.1PCSK1
41insulinoma30.0UCP2, UCP1, GHSR, GHRL, PCSK1, LEPR
42diabetic nephropathy30.0ADRB3, ENPP1, PPARG, UCP1
43adenoma30.0HSD11B1, PYY, PPARG, GHSR, GHRL, POMC
44familial hyperlipidemia30.0HSD11B1, UCP2, UCP1, UCP3, PPARG, LEP
45pre-eclampsia30.0LEP, LEPR, ADRB3, ADRB2
46rheumatoid arthritis30.0HSD11B1, GHRL, ADRB2
47ischemia30.0GHRL, ADRB2
48liver cirrhosis29.9LEP, LEPR
49multiple sclerosis29.9ADRB2, POMC, PPARG, UCP2
50hyperthyroidism29.9LEP, PCSK1, GHRL

Graphical network of the top 20 diseases related to Obesity:



Diseases related to obesity

Clinical Features for Obesity

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46OMIM
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Clinical features from OMIM:

601665,607514

Drugs & Therapeutics for Obesity

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Obesity

Drug clinical trials:

Search ClinicalTrials for Obesity

Search NIH Clinical Center for Obesity

Highlights from CenterWatch's Drugs in Clinical Trials Database for Obesity:

idCompanyCompoundMechanismPhase
1Ablaris TherapeuticsAdipotideA Prohibitin-Targeting Peptide 1I
2Zafgenbeloranib hemioxalatea MetAP2 inhibitor IIa
3Rhythm PharmaceuticalsRM-493a small-peptide MC4R agonistII
4High Point PharmaceuticalsHPP404A selective H3 receptor antagonistII
5Novo Nordiskliraglutidea GLP-1 derivativeIII

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Obesity

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20GeneTests, 22GTR
See all sources

Genetic tests related to Obesity:

id Genetic test Affiliating Genes
1 Obesity20 22

Anatomical Context for Obesity

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32MalaCards
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MalaCards organs/tissues related to Obesity:

32
Liver, Ovary, Heart, Adipocyte, Skeletal muscle, Bone, Kidney, Endothelial, Breast, Testes, Thyroid, Brain, Prostate, Pituitary, Monocytes, T cells, Colon, Skin, Lung, Hypothalamus, B cells, Pancreatic islet, Pancreas, Spinal cord, Myeloid, Salivary gland, Bone marrow, Lymph node, Small intestine, Placenta, Smooth muscle, Testis, Amygdala, Adrenal cortex, Pons, Spleen, Retina, Cerebellum, Eye, Nk cells, Whole blood, Cortex, Thymus

Animal Models for Obesity or affiliated genes

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36MGI
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Publications for Obesity

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50PubMed
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Articles related to Obesity:

(show top 50)    (show all 8795)
idTitleAuthorsYear
1
Correlates of body mass index and overweight and obesity of children aged 2 years: Findings from the Healthy Beginnings Trial. (24415528)
2014
2
Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity. (24093674)
2013
3
Obesity revisited, yet again. (24316987)
2013
4
Do genetic modifiers of high-density lipoprotein cholesterol and triglyceride levels also modify their response to a lifestyle intervention in the setting of obesity and type-2 diabetes mellitus?: The Action for Health in Diabetes (Look AHEAD) study. (23861364)
2013
5
Adiponectin, leptin and ghrelin levels in obese adolescent girls with polycystic ovary syndrome. (23158749)
2013
6
An association between -866G/A polymorphism in the promoter of UCP2 and obesity: a meta-analysis. (23147265)
2013
7
Influence of cardiac dysfunction and systemic inflammation on pulmonary function and airway responsiveness in obese subjects. (24088331)
2013
8
Association between obesity and dental caries in Chinese children. (23221967)
2013
9
Uncomplicated obesity in an African American population seeking medical weight loss. (24392606)
2013
10
Importance of the liver ultrasound scores in pubertal obese children with nonalcoholic fatty liver disease. (23601769)
2013
11
The soluble form of the receptor of advanced glycation endproducts increases after bariatric surgery in morbid obesity. (22828946)
2012
12
Preventive effect of Terminalia bellirica on obesity and metabolic disorders in spontaneously obese type 2 diabetic model mice. (22105160)
2012
13
Melanocortin-4 receptor gene mutations in a Dutch cohort of obese children. (20966905)
2011
14
Impact of unhealthy lifestyle behaviors and obesity on cholesteryl ester transfer protein among adolescent males. (21376264)
2011
15
REIN on obesity, proteinuria and CKD. (21617125)
2011
16
An INSIG2 polymorphism affects glucose homeostasis in Sardinian obese children and adolescents. (20645959)
2010
17
Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes. (20228173)
2010
18
Lean mean fat reducing "ghrelin" machine: hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity. (19573543)
2010
19
Comparison of early and late changes in immunoglobulins and acute phase reactants after laparoscopic adjustable gastric banding in patients with morbid obesity. (20066501)
2010
20
Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes. (20110184)
2010
21
Incretin hormone secretion in women with polycystic ovary syndrome: roles of obesity, insulin sensitivity, and treatment with metformin. (19375579)
2009
22
Bone mineral density and bone turnover in relation to serum leptin, alpha-ketoglutarate and sex steroids in overweight and obese postmenopausal women. (18547340)
2009
23
Prevention and reversal of obesity and glucose intolerance in mice by DHA derivatives. (19148125)
2009
24
Morbid obesity: issues and challenges in home health. (18469603)
2008
25
Omentin plasma levels and gene expression are decreased in obesity. (17329619)
2007
26
Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with benign breast disease. (17428620)
2007
27
Obesity and the clinical use of serum GGT activity as a marker of heavy drinking. (17763184)
2007
28
Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolism. (17148564)
2007
29
Unchanged asymmetric dimethylarginine levels in non-diabetic, premenopausal obese women who have common risk factors for cardiovascular disease. (17873318)
2007
30
Baseline leptin levels predict change in leptin levels during weight loss in obese breast cancer survivors. (17319860)
2007
31
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation presenting in childhood. (17606542)
2007
32
Emerging therapeutic strategies for obesity. (17122357)
2006
33
RhoA, Rho kinase, JAK2, and STAT3 may be the intracellular determinants of longevity implicated in the progeric influence of obesity: Insulin, IGF-1, and leptin may all conspire to promote stem cell exhaustion. (16226846)
2006
34
ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes]. (16527214)
2006
35
Common neuropeptide Y2 receptor gene variant is protective against obesity among Swedish men. (16331299)
2006
36
Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity. (16033253)
2005
37
Insulin resistance, obesity and the metabolic syndrome. Is there a therapeutic role for endothelin-1 antagonists? (16248779)
2005
38
Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity. (15181035)
2004
39
Genetic screening for melanocortin-4 receptor mutations in a cohort of Italian obese patients: description and functional characterization of a novel mutation. (14764812)
2004
40
Sagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia in obese men. (15277437)
2004
41
Hemorheological aspects of the metabolic syndrome: markers of insulin resistance, obesity or hyperinsulinemia? (15258344)
2004
42
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. (12176114)
2002
43
Thyroid hormones, obesity and brown adipose tissue thermogenesis]. (11721329)
2001
44
Circulating levels of free insulin-like growth factors in obese subjects: the impact of type 2 diabetes. (10585616)
1999
45
Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. (9769326)
1998
46
Short-term fasting in obesity fails to restore the blunted GH responsiveness to GH-releasing hormone alone or combined with arginine. (8736266)
1995
47
Obesity as a risk factor for developing non-insulin dependent diabetes mellitus--obesity and insulin resistance]. (7750630)
1995
48
Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7. (1358794)
1992
49
Obesity as risk factor for acute mountain sickness. (2572771)
1989
50
Mediastinal lipomatosis in simple obesity. (947702)
1976

Genetic Variations for Obesity

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Obesity:

62 (show all 30)
id Symbol AA change Variation ID SNP ID
1MC4Rp.Ser30ArgVAR_010704
2MC4Rp.Asp37ValVAR_010705rs13447325
3MC4Rp.Pro78LeuVAR_010706rs13447326
4MC4Rp.Arg165TrpVAR_010709rs13447332
5MC4Rp.Gly252SerVAR_010711rs13447336
6MC4Rp.Ile317ThrVAR_010712rs13447337
7MC4Rp.Asn274SerVAR_015357
8MC4Rp.Thr11AlaVAR_038632
9MC4Rp.Ser36TyrVAR_038633
10MC4Rp.Val50MetVAR_038634
11MC4Rp.Ser58CysVAR_038635
12MC4Rp.Asn62SerVAR_038636
13MC4Rp.Asn97AspVAR_038638
14MC4Rp.Ile102SerVAR_038639
15MC4Rp.Ile102ThrVAR_038640
16MC4Rp.Leu106ProVAR_038641
17MC4Rp.Ile125LysVAR_038642
18MC4Rp.Ser127LeuVAR_038643rs13447331
19MC4Rp.Arg165GlnVAR_038644rs13447332
20MC4Rp.Ile170ValVAR_038645rs121913560
21MC4Rp.Ala175ThrVAR_038646
22MC4Rp.Gly181AspVAR_038647rs13447333
23MC4Rp.Ala219ValVAR_038648
24MC4Rp.Val253IleVAR_038650rs187152753
25MC4Rp.Cys271ArgVAR_038651
26MC4Rp.Cys271TyrVAR_038652
27MC4Rp.Ile316SerVAR_038653
28MC4Rp.Leu325PheVAR_038654
29PPARGp.Pro113GlnVAR_010724rs1800571
30UCP3p.Val102IleVAR_004408rs2229707

Expression for genes affiliated with Obesity

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Obesity

Search GEO for disease gene expression data for Obesity.

Pathways for genes affiliated with Obesity

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 49PharmGKB
See all sources

Pathways related to Obesity according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
13.1ADRB2, PYY, GHSR, GHRL, FFAR4, POMC
2
Hide members
12.7PYY, GHSR, GHRL, FFAR4, POMC, MC4R
3
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11.8UCP2, UCP1, UCP3, PPARG, LEP, LEPR
4
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11.4UCP1, PPARG, ADRB3, ADRB2
5
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11.4PYY, ADRB3, ADRA2B, ADRB2
6
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11.1ADRB2, ADRA2B, ADRB3
7
Hide members
11.1UCP2, UCP1, UCP3
8
Hide members
11.1GHRL, POMC, PCSK1
911.1PPARG, UCP3, UCP2
1011.1LEP, GHSR, UCP3
11
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
11.1LEPR, LEP, POMC
1211.1POMC, LEP, LEPR
13
Hide members
10.9PCSK1, GHRL
1410.9MC4R, POMC
15
Hide members
10.9PCSK1, POMC

Compounds for genes affiliated with Obesity

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Obesity according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1lipid4414.5GHSR, ADRB2, UCP2, UCP1, UCP3, PPARG
2glucose4413.6POMC, UCP2, PYY, PPARG, UCP1, UCP3
3cholesterol44 28 11 2416.6PPARG, LEPR, LEP, MC4R, ADRB3, UCP3
4dexamethasone44 49 28 1116.1ADRB3, ADRB2, ENPP1, PPARG, GHSR, GHRL
5arginine4413.1LEP, POMC, LEPR, GHSR, PYY, ADRB3
6alanine4413.1GHRL, PPARG, ADRB3, LEPR, MC4R, POMC
7acth4412.9HSD11B1, PYY, GHSR, GHRL, POMC, MC4R
8fatty acid4412.9UCP3, HSD11B1, PYY, UCP1, PPARG, GHRL
9ribonucleic acid4412.9UCP3, LEPR, PCSK1, GHSR, UCP1, HSD11B1
10testosterone44 59 11 2415.9GHRL, UCP1, PPARG, GHSR, HSD11B1, LEP
11nitric oxide44 11 2414.8UCP1, ADRB3, UCP2, LEPR, UCP3, GHSR
12triiodothyronine4412.7GHRL, UCP3, UCP1, UCP2, HSD11B1, POMC
13cocaine44 1113.7ADRB2, LEPR, LEP, MC3R, POMC, PYY
14norepinephrine44 11 2414.5ADRB3, POMC, UCP1, UCP2, ADRA2B, PYY
15corticosterone44 59 2414.5MC4R, HSD11B1, POMC, GHRL, MC3R, LEPR
16rosiglitazone44 49 28 11 2416.4LEP, GHRL, UCP3, UCP1, UCP2, HSD11B1
17dopamine44 28 11 2415.4ADRB2, PYY, GHSR, GHRL, MC4R, LEPR
18thyroxine44 2413.4PPARG, LEPR, LEP, UCP1, POMC, GHRL
19serine4412.4ADRB2, LEPR, LEP, PCSK1, POMC, GHRL
20estradiol44 11 2414.4HSD11B1, PYY, GHSR, GHRL, LEP, LEPR
21glutamine4412.3LEPR, ENPP1, ADRB2, POMC, UCP2, HSD11B1
22gnrh4412.2ADRB2, LEPR, MC3R, GHRL, PCSK1, PYY
23c-peptide4412.2PCSK1, PYY, LEP, GHRL, ADRB3, UCP1
24clozapine44 28 49 1115.2POMC, ADRB2, ADRB3, LEP, GHRL, ADRA2B
25adenylate4412.1POMC, GHRL, PCSK1, ADRB2, ADRB3, GHSR
26cyclic amp44 2413.1GHRL, ENPP1, ADRB3, MC3R, ADRB2, UCP1
27epinephrine44 11 2414.0GHRL, ADRB2, POMC, ADRA2B, ADRB3, LEP
28thiazolidinedione4412.0LEP, UCP1, UCP2, PPARG, UCP3
29olanzapine49 44 28 11 2416.0ADRB3, LEPR, ADRA2B, GHRL, LEP
302-deoxyglucose44 1112.9PYY, PPARG, GHRL, POMC, UCP3
31metformin44 49 1113.9PPARG, GHRL, POMC, LEP, ENPP1
32catecholamine4411.9UCP2, UCP1, POMC, ADRB3, ADRB2
33estrogen4411.8HSD11B1, PCSK1, UCP3, ADRB3
34shu 911944 5912.8POMC, MC4R, MC3R, LEP
35alpha msh4411.7MC3R, LEP, MC4R, POMC
36progesterone44 59 28 11 2415.7UCP1, ADRB2, LEPR, LEP, PCSK1, HSD11B1
37intralipid4411.7UCP3, LEP, GHRL, PYY
38oxyntomodulin44 5912.7PCSK1, LEP, GHRL, PYY
39forskolin44 49 1113.7POMC, ADRB2, HSD11B1, GHSR
40orlistat44 59 1113.7GHRL, LEP, PPARG, PYY
41palmitate4411.6UCP2, UCP1, UCP3, MC4R
42bezafibrate44 28 1113.5UCP1, UCP3, PPARG, UCP2
43pg 1065911.4MC4R, MC3R, POMC
44[d-trp8]-gamma-msh5911.4POMC, MC3R, MC4R
45hs 0145911.4MC3R, MC4R, POMC
46alpha-msh5911.4POMC, MC4R, MC3R
47p0034411.4UCP3, PYY, UCP1
48naloxone44 49 28 1114.4POMC, ADRB2, LEP, GHRL
49amphetamine44 1112.3PYY, POMC, MC4R, GHRL
50clenbuterol44 1112.1ADRB2, ADRB3, LEP

GO Terms for genes affiliated with Obesity

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16Gene Ontology
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Cellular components related to Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.8ENPP1, LEP, PCSK1, POMC, GHRL, PYY
2secretory granule lumenGO:03477410.8PCSK1, POMC, GHRL

Biological processes related to Obesity according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1brown fat cell differentiationGO:05087311.8ADRB2, ADRB3, PPARG, UCP1
2response to coldGO:00940911.8UCP3, PPARG, ADRB3, ADRB2
3adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718811.8MC4R, MC3R, ADRB3, ADRB2
4cellular response to insulin stimulusGO:03286911.7UCP2, PPARG, GHSR, ENPP1
5regulation of blood pressureGO:00821711.7PPARG, POMC, MC3R, LEP
6energy reserve metabolic processGO:00611211.7ADRB3, LEPR, LEP, MC4R
7diet induced thermogenesisGO:00202411.5ADRB2, ADRB3, MC4R
8adult feeding behaviorGO:00834311.5GHSR, GHRL, LEP
9cell-cell signalingGO:00726711.5ADRA2B, PCSK1, POMC, PYY
10mitochondrial transportGO:00683911.5UCP3, UCP1, UCP2
11eating behaviorGO:04275511.5PYY, LEP, ADRB3
12proton transportGO:01599211.5UCP2, UCP1, UCP3
13response to insulin stimulusGO:03286811.4UCP3, MC4R, LEP
14generation of precursor metabolites and energyGO:00609111.4POMC, ENPP1, ADRB3
15negative regulation of inflammatory responseGO:05072811.4FFAR4, GHRL, GHSR
16positive regulation of MAPK cascadeGO:04341011.4ADRB2, ADRB3, LEP
17G-protein coupled receptor signaling pathwayGO:00718611.3PYY, GHSR, GHRL, ADRA2B
18positive regulation of appetiteGO:03210011.3GHSR, GHRL
19heat generationGO:03164911.2ADRB3, ADRB2
20desensitization of G-protein coupled receptor protein signaling pathway by arrestinGO:00203211.2ADRB3, ADRB2
21vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:00202511.2ADRB3, ADRB2
22response to superoxideGO:00030311.2UCP3, UCP2
23respiratory electron transport chainGO:02290411.2UCP2, UCP1, UCP3
24negative regulation of tumor necrosis factor biosynthetic processGO:04253611.2GHRL, GHSR
25negative regulation of interleukin-6 biosynthetic processGO:04540911.2GHSR, GHRL
26negative regulation of interleukin-1 beta productionGO:03269111.1GHSR, GHRL
27growth hormone secretionGO:03025211.1GHRL, GHSR
28actin polymerization or depolymerizationGO:00815411.0GHSR, GHRL
29negative regulation of multicellular organism growthGO:04001510.9ADRB2, ADRB3
30decidualizationGO:04669710.9GHRL, GHSR
31peptide hormone processingGO:01648610.6PCSK1, POMC

Molecular functions related to Obesity according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone bindingGO:01704611.3MC3R, MC4R, GHSR
2hormone activityGO:00517911.1LEP, POMC, PYY
3oxidative phosphorylation uncoupler activityGO:01707711.1UCP3, UCP1
4melanocyte-stimulating hormone receptor activityGO:00498011.0MC4R, MC3R
5norepinephrine bindingGO:05138011.0ADRB2, ADRB3
6epinephrine bindingGO:05137910.9ADRB3, ADRA2B
7melanocortin receptor activityGO:00497710.8MC4R, MC3R
8neuropeptide bindingGO:04292310.6MC3R, MC4R

Products for genes affiliated with Obesity

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Sources for Obesity

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
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50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet