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MCID: OBS005

Obesity malady
22 drugs, 1128 genes, 43 tissues, 997 related diseases, 29 phenotypes, 5479 articles, clinical trials, genetic tests.

Summaries for Obesity

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23MedlinePlus, 44Wikipedia, 33OMIM, 22MalaCards
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MedlinePlus: Obesity means having too much body fat. it is different from being overweight, which means weighing too much. the weight may come from muscle, bone, fat and/or body water. both terms mean that a person's weight is greater than what's considered healthy for his or her height. obesity occurs over time when you eat more calories than you use. the balance between calories-in and calories-out differs for each person. factors that might tip the balance include your genetic makeup, overeating, eating high-fat foods and not being physically active. being obese increases your risk of diabetes, heart disease, stroke, arthritis and some cancers. if you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases. nih: national institute of diabetes and digestive and kidney diseases23

MalaCards: Obesity is related to carcinoma and prostatitis. An important gene associated with Obesity is LEP (leptin), and among its related pathways are Neuroactive ligand-receptor interaction and Cytokine-cytokine receptor interaction. The drugs mazindol and phentermine and the compounds glucose and cyclic amp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotypes are immune system and growth/size.

Wikipedia: Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have...44 more...

OMIM: 601665

Aliases & Descriptions for Obesity

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6Disease Ontology, 7diseasecard, 16GeneTests, 17Genetics Home Reference, 33OMIM, 32Novoseek , 23MedlinePlus, 43UMLS, 40SNOMED-CT, 27NCIt, 24MeSH, 19ICD9CM
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Aliases & Descriptions:

obesity 6 7 16 17 33 32 23 43

External Ids:

NCIt27 C3283
SNOMED-CT40 414916001, 414915002, 190963004 5476005, 154776002, more
ICD9CM19 278.00

Related Diseases for Obesity

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13GeneCards, 14GeneDecks
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Diseases related to obesity by text searches and GeneDecks gene sharing:

(show top 50)    (show all 994)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma148.9PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
2prostatitis135.2PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
3neuronitis133.1PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
4pancreatitis130.4PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
5diabetes mellitus128.5PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, WDPCP
6cholesterol128.1PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
7insulin resistance118.4ZNF318, PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1
8hypertension112.7PIK3CB, PIK3R1, PIK3C2A, PIK3CG, WDPCP, LRP1
9leukemia111.0PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
10atherosclerosis109.5PIK3C2A, PIK3CG, LRP1, LRP5, COG2, RECK
11thyroiditis106.5PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
12adenocarcinoma103.3PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
13alzheimer's disease102.3ZNF248, PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1
14colorectal cancer98.5ZNF318, PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP5
15arthritis94.5PIK3CG, LRP1, LRP5, RECK, RELA, RETN
16hypoxia92.5PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
17fibrosis90.7PIK3CA, PIK3CG, LRP1, NCOA3, RECK, REG3A
18rheumatoid arthritis88.9PIK3CG, LRP1, LRP5, RECK, RELA, RETN
19cerebritis87.8PIK3R1, PIK3C2A, PIK3CG, LRP1, COG2, RELA
20ischemia86.4PIK3CA, PIK3C2A, PIK3CG, COG2, RELA, REN
21ovarian cancer84.9ZNF318, PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1
22myocardial infarction84.6PIK3C2A, PIK3CG, LRP1, COG2, RECK, REN
23retinitis84.6PIK3CA, PIK3C2A, PIK3CG, LRP1, LRP5, PDE3B
24schizophrenia79.7PIK3CB, PIK3CA, PIK3R1, PIK3CG, PID1, NCOR2
25esophagitis79.5PIK3CB, PIK3CA, PIK3C2A, PIK3CG, NCOA3, RECK
26adenoma79.3PIK3CA, NCOA3, NCOR2, RECK, REG3A, REN
27coronary heart disease79.0PIK3C2A, LRP1, LRP5, COG2, RETN, VWF
28nephropathy77.7LRP1, COG2, RELA, REN, RETN, VWF
29colon cancer76.4PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCOR2, RECK
30type 2 diabetes mellitus75.0PIK3R1, COG2, PDE3B, RECK, RETN, CNR1
31hyperglycemia73.7PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, COG2
32cervicitis70.7PIK3CA, PIK3CG, NCR3, RECK, RELA, REN
33blindness70.3PIK3C2A, PIK3CG, LRP5, COG2, REN, CNR1
34essential hypertension69.7COG2, REN, RETN, KISS1, VWF, GCK
35anorexia nervosa69.6PIK3C2A, SH2B1, COG2, RETN, CNR1, CNR2
36twinning65.9ZNF318, PIK3R1, LRP1, SH2B1, COG2, REN
37obesity, association with65.0ZNF642, RETN, CNR1, VWF, RBP4, SERPINA12
38gonococcal synovitis64.9PIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1, PDE3B
39hyperlipidemia64.7PIK3CB, PIK3C2A, PIK3CG, LRP1, COG2, RETN
40osteoarthritis62.6PIK3CB, PIK3CG, LRP5, NCOR2, RELA, RETN
41anemia62.3RELA, REN, VWF, PCNA, SELE, SELL
42acute myocardial infarction61.1PIK3C2A, PIK3CG, COG2, REN, RETN, CNTF
43homocysteine60.8PIK3R1, PIK3C2A, COG2, RELA, REN, RETN
44psoriasis60.0LRP1, RETN, CNR1, KIR2DL1, KIR2DL3, KIR2DS4
45dementia59.9PIK3C2A, PIK3CG, LRP1, VWF, SFTPD, PCSK9
46infertility59.5PIK3C2A, RETN, KISS1, KIR2DL1, KIR2DL3, GC
47hypercholesterolemia59.4PIK3C2A, LRP1, COG2, RETN, VWF, PCSK9
48osteoporosis58.4LRP5, CNR1, CNR2, VPS13B, GCG, GC
49thrombosis57.9PIK3C2A, PIK3CG, LRP1, COG2, RECK, REN
50hepatocellular carcinoma57.5PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCOA3, NCR3

Graphical network of the top 20 diseases related to obesity:



Graphical network of diseases related to obesity

Clinical Features for Obesity

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33OMIM
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Clinical features from OMIM: 601665

Drugs & Therapeutics for Obesity

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for obesity

Drug clinical trials:

Search ClinicalTrials for obesity

Search NIH Clinical Center for obesity

Search CenterWatch for obesity

Inferred drug relations via UMLS/NDF-RT:

43 28 benzphetamine, benzphetamine hydrochloride, dexfenfluramine, dexfenfluramine hydrochloride, diethylpropion, diethylpropion hydrochloride, fenfluramine, fenfluramine hydrochloride, mazindol, orlistat, phendimetrazine, phendimetrazine hydrochloride, phendimetrazine tartrate, phenmetrazine, phenmetrazine hydrochloride, phentermine, phentermine hydrochloride, phentermine resin complex, phenylpropanolamine, phenylpropanolamine hydrochloride, sibutramine, sibutramine hydrochloride

Genetic Tests for Obesity

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16GeneTests
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Genetic tests related to obesity:

id Genetic test Affiliating Genes
1 Obesity
clinical/research 		MC4R, ADRB2

Anatomical Context for Obesity

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22MalaCards
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MalaCards organs/tissues related to obesity:

22
Bone marrow, Whole blood, Spleen, Brain, Cortex, Spinal cord, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Kidney, Liver, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Ovary, Placenta, Prostate, Testis, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Prefrontal cortex, Hypothalamus, Pons, Cardiac myocytes, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Adrenal cortex, Pituitary, Testis germ

Phenotypes for genes affiliated with Obesity

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25MGI
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MGI Mouse Phenotypes related to obesity:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1immune system phenotypeMP:0005387INFLRP1, LRP5, SH2B1, RFTN1, NCOA3, REN
2growth/size phenotypeMP:0005378INFPIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
3cellular phenotypeMP:0005384INFPIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP5, RFTN1
4mortality/agingMP:0010768INFPIK3CB, PIK3CA, PIK3C2A, LRP1, LRP5, SH2B1
5behavior/neurological phenotypeMP:0005386INFPIK3CA, LRP1, LRP5, NCOA3, NCOR2, PDE10A
6muscle phenotypeMP:0005369INFPIK3CA, PIK3R1, PIK3CG, LRP1, NCOA3, RELA
7endocrine/exocrine gland phenotypeMP:0005379INFLRP5, SH2B1, KISS1, PCSK2, PCSK1, SELL
8cardiovascular system phenotypeMP:0005385INFPIK3CB, PIK3CA, PIK3R1, PIK3CG, LRP1, LRP5
9liver/biliary system phenotypeMP:0005370INFLRP5, NCOA3, NCOR2, RECK, RETN, PCSK9
10hematopoietic system phenotypeMP:0005397INFCNTF, PCNA, PCSK1, BMP4, BMPR1A, LITAF
11reproductive system phenotypeMP:0005389INFPIK3CA, SH2B1, NCOA3, REN, KISS1, KIF11
12normal phenotypeMP:0002873INFPIK3R1, LRP1, LRP5, NCAM2, NCOA3, RELA
13renal/urinary system phenotypeMP:0005367INFNCOA3, REN, KISS1, PCBD1, GCK, SELP
14respiratory system phenotypeMP:0005388INFSFTPD, SELL, SELP, LPL, BMPR1A, BMPR2
15vision/eye phenotypeMP:0005391INFPIK3CA, LRP5, RELA, , PCBD1, RBP4
16tumorigenesisMP:0002006INFPIK3CB, PIK3CA, PIK3R1, NCOA3, SELL, SERPINE1
17pigmentation phenotypeMP:0001186INFLRP5, PDE3B, PCBD1, SERPINC1, SERPINF1, LMNA
18limbs/digits/tail phenotypeMP:0005371INFLRP5, RECK, RELA, , VEGFA, VDR
19craniofacial phenotypeMP:0005382INFLRP5, NCOA3, NCOR2, BMP4, BMPR1A, RARG
20other phenotypeMP:000539515.8RECK, CNR1, RARG, RARA, RARB, CLU
21no phenotypic analysisMP:0003012INFPIK3R1, CNR1, , PCNA, PCK1, SERPINA6
22embryogenesis phenotypeMP:0005380INFPIK3CB, PIK3CA, LRP5, NCOA3, RECK,
23digestive/alimentary phenotypeMP:0005381INFNCOA3, NCOR2, KISS1, VWF, PCSK1, GCG
24homeostasis/metabolism phenotypeMP:0005376INFPIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
25integument phenotypeMP:0010771INFPIK3CG, NCOA3, PDE3B, RECK, RELA, CNR1
26nervous system phenotypeMP:0003631INFLRP1, LRP5, NCAM2, RECK, RELA, REN
27hearing/vestibular/ear phenotypeMP:0005377INFNCOA3, VDR, LMNA, BMP2, BMP4, BMPR1A
28adipose tissue phenotypeMP:0005375INFPIK3CA, PIK3R1, PIK3C2A, LRP1, NCOA3, NCOR2
29skeleton phenotypeMP:0005390INFPIK3CG, LRP1, RECK, RELA, CNR1,

Publications for genes affiliated with Obesity

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35PubMed
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Articles related to obesity:

(show top 50)    (show all 5479)
idTitleAuthorsYearAffiliating Genes
1Nocturnal falls of adiponectin levels in sleep apnea with abdominal obesity and impact of hypoxia-induced dysregulated adiponectin p roduction in obese murine mesenteric adipose tissue. (21139317)Nakagawa Y.... Shimomura I.2011ADIPOQ
2rs9939609 in the FTO gene is associated with obesity but not with several biochemical parameters in Sardinian obese children. (21913894)Zavattari P.... Loche S.2011FTO
3Plasma adipokine and inflammatory marker concentratio ns are altered in obese, as opposed to non-obese, type 2 diabetes patients. (20131064)Hansen D.... van Loon L.J.2010IL6, RETN
4Associations of six single nucleotide polymorphisms i n obesity-related genes with BMI and risk of obesity in Chinese children. (20843981)Wu L.... Mi J.2010BDNF, NPC1, MC4R
5Less increase of BNP and NT-proBNP levels in obese patient with decompensated heart failure: interpretation of natriuretic peptides in obesity. (18089293)KAolsch H.... Erbel R.2009NPPB
6Obesity, coffee consumption and CRP levels in postmen opausal overweight/obese women: importance of hormone replacement therapy use. (19756031)Arsenault B.J.... Church T.S.2009CRP
7In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes. (19097921)ClAcment K.... BougnA"res P.2009PIK3CG, PIK3CB
8Racial difference in Acylation Stimulating Protein (ASP) correlates to triglyceride in non-obese and obese African American and Caucasian women. (19374759)Scantlebury-Manning T.... Barakat H.2009C3, APOB
9IL-18 and IL-18 binding protein concentrations in serum and ovarian follicular fluid do not affect in vitro fertilization outcomes in obese, overweight, and non-obese patients. (19097647)Kilic S.... Dogan M.2009IL18, IL18BP
10PPAR-gamma2 Pro12Ala polymorphism in the population of obese and non-obese men of the city of Wroclaw. (18777501)Kuliczkowska J.... Milewicz A.2008PPARG
11Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. (18249188)Jacobsson J.A.... Fredriksson R.2008FTO
12Prevalence of vitamin D insufficiency and deficiency in morbidly obese patients: a comparison with non-obese controls. (18175194)Goldner W.S.... McBride C.2008ALB
13Serum retinol-binding protein 4 is not increased in obesity or obesity-associated type 2 diabetes mellitus, but is reduced after relevant reductions in body fat following gastric bypass. (18081728)Gomez-Ambrosi J.... Fruhbeck G.2008RBP4
14Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. (18647953)Qi L.... Hu F.B.2008FTO
15Circulating serum adiponectin concentrations do not differ between obese and non-obese caucasians and are unrelated to insulin sensitivity. (17226110)Owecki M.... SowiA8ski J.2007ADIPOQ
16Studies of the SIM1 gene in relation to human obesity and obesity-related traits. (16924270)Hung C.C.... Farooqi I.S.2007SIM1
17Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. (18159244)Hinney A.... Hebebrand J.2007FTO
18Association of gene polymorphism at cholesterol ester transfer protein locus with obesity and response to dietary intervention in obesity (16986521)Huang Z.Y.... Xue K.2006CETP
19Comparison of fibrinolytic and metabolic system parameters in obese patients with polycystic ovary syndrome and women with simple obesity. (17145652)SA8opieA8 R.... Warenik-Szymankiewicz A.2006PRL, INS
20Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes. (16059715)Lee Y.H.... Permana P.A.2005CCL2, CCL3
21Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. (15604215)Khamzina L.... Marette A.2005IRS1, MTOR
22Adipocyte insensitivity syndromes -- novel approach to nutritional metabolic problems including obesity and obesity related disorders. (15694704)Erol A.2005ADD1
23The aerobic fitness (VO2 peak) and alpha-fibrinogen genetic polymorphism in obese and non-obese Chinese boys. (15795809)He Z.H.... Ma L.H.2005FGA
24Effects of metformin and ethinyl estradiol-cyproterone acetate on lipid levels in obese and non-obese women with polycystic ovary syndrome. (15745936)Rautio K.... Morin-Papunen L.C.2005INS
25PON1 polymorphism, diabetes mellitus, obesity, and risk of myocardial infarction: Modifying effect of diabetes mellitus and obesity on the association between PON1 polymorphism and myocardial infarction. (15654230)Li J.... Xu X.2005PON1
26Differences in the pharmacokinetics of peroxisome proliferator-activated receptor agonists in genetically obese Zucker and sprague-dawley rats: implications of decreased glucuronidation in obese Zucker rats. (15319330)Kim M.S.... Vincent S.H.2004ABCC2
27Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. (15331560)Hung C.C.... Farooqi I.S.2004NPY2R, PYY
28Molecular screening of the ghrelin gene in Italian obese children: the Leu72Met variant is associated with an earlier onset of obesity. (14724664)Miraglia del Giudice E.... Perrone L.2004GHRL
29Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance. (12823641)Vgontzas A.N.... Chrousos G.P.2003IL6, LEP, INS
30Differences in plasminogen activator inhibitor 1 in subcutaneous versus omental adipose tissue in non-obese and obese subjects. (12734779)He G.... Richelsen B.2003SERPINE1
31Diet-dependent obesity and hypercholesterolemia in th e New Zealand obese mouse: identification of a quantitative trait locus for ele vated serum cholesterol on the distal mouse chromosome 5. (12727230)Giesen K.... Joost H.G.2003INS
32Mutations in the adiponectin gene in lean and obese subjects from the Swedish obese subjects cohort. (12870165)Ukkola O.... Bouchard C.2003ADIPOQ
33Metabolic changes following sibutramine-assisted weight loss in obese individuals: role of plasma free fatty acids in the insulin resistance of obesity. (11436188)McLaughlin T.... Reaven G.M.2001INSR, INS
34Circulating IGF binding protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women. (11248749)Soderberg S.... Olsson T.2001IGFBP1
35Plasma beta-endorphin levels in obese and non-obese patients with polycystic ovary disease. (11293919)MartA-nez-Guisasola J.... Ferrer J.2001PRL, SHBG
36Follistatin and activin A serum concentrations in obese and non-obese patients with polycystic ovary syndrome. (11726573)Eldar-Geva T.... Homburg R.2001FST
37Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. (10650936)Livingstone D.E.... Walker B.R.2000NR3C1, HSD11B1, SRD5A1
38Testing of human homologues of murine obesity genes as candidate regions in Finnish obese sib pairs. (10196693)Ohman M.... Peltonen L.1999UCP2, MC4R, UCP3
39Influence of duration of obesity on the insulin resistance of obese non-diabetic patients. (9539195)Muscelli E.... Ferrannini E.1998INS
40Adipose tissue secretion of plasminogen activator inhibitor-1 in non-obese and obese individuals. (9498632)Eriksson P.... Arner P.1998SERPINE1
41Hyperinsulinemia and sex hormones in healthy premenopausal women: relative contribution of obesity, obesity type, and duration of obesity. (9440471)IvandiA8 A.... JuriA8 M.1998INS, SHBG
42DNA polymorphism in the uncoupling protein 1 (UCP1) gene has no effect on obesity related phenotypes in the Swedish Obese Subjects cohorts. (9665669)Gagnon J.... Bouchard C.1998UCP1
43Association of central obesity and insulin resistance with high prevalence of diabetes and cardiovascular disease in an elderly population with low fat intake and lower than normal prevalence of obesity: the Indian paradox. (9861517)Singh R.B.... Postiglione A.1998INS
44Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity. (9349603)Matsuoka N.... Nakao K.1997LEPR
45Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity. (8621021)Niki T.... Kasuga M.1996LEP
46The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the QuAcbec Family Study and Swedish Obese Subjects cohorts. (8903328)Gagnon J.... Bouchard C.1996ADRB3
47Obesity as a risk factor for developing non-insulin dependent diabetes mellitus--obesity and insulin resistance (7750630)Maegawa H.... Shigeta Y.1995INSR
48Comparison of obese and non-obese patients with gestational diabetes. (8242130)Comtois R.... Beauregard H.1993INS
49Effects of alcohol intake and obesity on serum liver enzyme activity in obese men with mild hypertension. (8099118)Fagerberg B.... Berglund G.1993GPT
50RFLP analysis of the MHC class III region defines unique haplotypes for the non-obese diabetic, cataract Shionogi and the non-obese non-diabetic mouse strains. (8104833)Lund T.... Cooke A.1993VARS

Expression for genes affiliated with Obesity

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Obesity

Pathways for genes affiliated with Obesity

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20KEGG, 36QIAGEN, 38Reactome, 10EMD Millipore, 41Thomson Reuters
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Pathways related to obesity according to GeneDecks:

(show top 50)    (show all 160)
idPathwayScoreTop Affiliating Genes
1Neuroactive ligand-receptor interaction2021.9CNR1, CNR2, GCGR, BRS3, LPAR3, BDKRB2
2Cytokine-cytokine receptor interaction2019.2CNTF, CNTFR, VEGFA, VEGFC, BMP2, BMPR1A
3Tec Kinases Signaling3618.9PIK3R1, BTC, VEGFC, BMP2, BMP4, BMP6
4JAK-STAT Pathway3618.7PIK3R1, BTC, VEGFC, BMP2, BMP4, BMP6
5Akt Signaling3618.6PIK3R1, PIK3CG, PDE3B, BTC, VEGFC, BMP2
6MAPK Family Pathway3617.6PIK3R1, BTC, VEGFC, BMP2, BMP4, BMP6
7STAT3 Pathway3617.1BMP2, BMP4, BMP6, BMPR1A, BMPR2, RAC1
8Adipocytokine signaling pathway2017.1RELA, PCK2, PCK1, LEP, LEPR, CHUK
9Class A/1 (Rhodopsin-like receptors)3816.8CNR1, CNR2, MTNR1A, MTNR1B, S1PR5, FSHR
10TGF-Beta Pathway3616.6PIK3R1, BTC, VEGFC, BMP2, BMP4, BMP6
11ILK Signaling3615.5PIK3R1, BTC, VEGFC, BMP2, BMP4, RAC1
12Glucocorticoid Receptor Signaling3615.2NCOA3, NCOR2, BMP2, BMP4, BMP6, CEBPB
13NF-KappaB Family Pathway3615.1PIK3R1, RELA, BTC, VEGFC, BMP2, BMP4
14all-trans-Retinoic Acid Signaling in Brain3614.9BMP2, BMP4, BMP6, RARG, RARA, RARB
15Jak-STAT signaling pathway2014.9PIK3CB, PIK3CA, PIK3R1, PIK3CG, CNTF, CNTFR
16MIF Mediated Glucocorticoid Regulation3614.8BMP2, BMP4, BMP6, LIF, CD2, CD14
17PGC1Alpha Pathway3614.7BMP2, BMP4, BMP6, CD2, INSR, IL10RA
18IL-6 Pathway3614.7PIK3R1, BMP2, BMP4, BMP6, CD2, IL10
19Endothelin-1 Signaling Pathway3614.7PIK3R1, BMP2, BMP4, BMP6, CD2, FLT1
20Chemokine signaling pathway2014.7PIK3CB, PIK3CA, PIK3R1, PIK3CG, RELA, RAC1
21Regulation of eIF4 and p70S6K3614.5PIK3R1, VEGFC, BMP2, BMP4, CD2, ITGAD
22JNK Pathway3614.3PIK3R1, BTC, BMP2, BMP4, BMP6, RAC1
23Rac1 Pathway3614.3PIK3R1, BTC, VEGFC, BMP2, BMP4, BMP6
24Apoptotic Pathways in Synovial Fibroblasts3614.2PIK3R1, BTC, VEGFC, BMP2, BMP4, BMP6
25MIF Regulation of Innate Immune Cells3614.1BMP2, BMP4, BMP6, LIF, JUN, CD2
26Osteoclast differentiation2013.8PIK3CB, PIK3CA, PIK3R1, PIK3CG, RELA, RAC1
27Selected targets of GCR-alpha1013.7LPIN1, LEP, UCP3, BACE1, CGA, INS
28Rheumatoid arthritis2013.5VEGFA, JUN, ITGB2, MMP3, FOS, FLT1
29Development_IGF-1 receptor signaling4113.4PIK3CB, PIK3CA, PIK3R1, RELA, CHUK, MTOR
30Transcription_Role of VDR in regulation of genes involved in osteoporosis4113.4VDR, BGLAP, CGA, JUN, FOS, AR
31Type II diabetes mellitus2013.3PIK3CB, PIK3CA, PIK3R1, GCK, KCNJ11, IRS1
32Chagas disease (American trypanosomiasis)2013.2PIK3CB, PIK3CA, PIK3R1, PIK3CG, RELA, SERPINE1
33Toxoplasmosis2013.2PIK3CB, PIK3CA, PIK3R1, PIK3CG, RELA, CIITA
34Development IGF-RI signaling1013.0PIK3CB, PIK3CA, PIK3R1, RELA, CHUK, MTOR
35Transcription Role of VDR in regulation of genes involved in osteoporosis1013.0VDR, BGLAP, CGA, JUN, FOS, AR
36Development_VEGF signaling via VEGFR2 - generic cascades4111.6PIK3CB, PIK3CA, PIK3R1, RELA, VEGFA, RAC1
37Development_EGFR signaling pathway4111.4PIK3CB, PIK3CA, PIK3R1, BTC, RAC1, CHUK
38Immune response MIF-mediated glucocorticoid regulation1011.2RELA, VCAM1, CHUK, JUN, FOS, MIF
39Immune response_MIF-mediated glucocorticoid regulation4111.2RELA, VCAM1, CHUK, JUN, FOS, MIF
40SOCS Pathway36INFVEGFC, BMP2, BMP4, BMP6, CISH,
41ERK Signaling36INFPIK3R1, BTC, VEGFC, BMP2, BMP4, BMP6
42Insulin signaling pathway20INFPIK3CB, PIK3CA, PIK3R1, PDE3B, PCK2, PCK1
43GPCR Pathway36INFPIK3R1, BTC, VEGFC, BMP2, BMP4, BMP6
44Activation of PKA through GPCR36INFPDE3B, GCG, GCGR, BTC, VEGFC, BMP2
45MAPK Signaling36INFPIK3R1, BTC, VEGFC, BMP2, BMP4, BMP6
46Signaling Involved in Cardiac Hypertrophy36INFPIK3R1, RAC1, LIF, JUN, JAK2, ITGAD
47Antioxidant Action of Vitamin-C36INFBTC, VEGFC, BMP2, BMP4, BMP6, BMPR1A
48Renin-Angiotensin Pathway36INFPIK3R1, REN, BTC, VEGFC, VCAM1, BMP2
49NF-KappaB (p50-p65) Pathway36INFPIK3R1, RELA, BTC, VEGFC, BMP2, BMP4
50AMPK Enzyme Complex Pathway36INFPIK3R1, LIPE, CKM, LEP, MLYCD, GYS1

Compounds for genes affiliated with Obesity

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Sources:
32Novoseek , 18HMDB, 9DrugBank, 34PharmGKB, 42Tocris Bioscience
See all sources

Compounds related to obesity according to GeneDecks:

(show top 50)    (show all 563)
idCompoundScoreTop Affiliating Genes
1glucose32 INFREG3A, CNTF, KISS1, PC, PCSK2, PCSK1
2cyclic amp32 18 INFPIK3R1, NCOR2, PDE10A, PDE3B, CNR1, CNR2
3cholesterol32 9 18 9 51.3PIK3CB, PIK3CA, PIK3R1, PIK3C2A, LRP1, LRP5
4atp32 36.3PIK3CB, PIK3CA, PIK3C2A, PDE3B, RECK, KIR3DL1
5genistein32 9 18 9 29.5PIK3CA, PIK3R1, PIK3CG, CNTF, PCK2, PCNA
6hydrogen32 18 26.4CNR2, KIR3DL1, PCSK9, GCK, RARA, RAC1
7arachidonic acid32 9 18 9 28.3PIK3CA, RECK, CNR1, VWF, SELP, LPL
8thymidine32 18 26.2PIK3CA, PIK3R1, PDE3B, REG3A, CNR2, CNTF
9ethanol32 34 9 18 9 26.6LPA, BPI, RARB, LIPE, LIPC, CLU
10pd 98,05932 21.9PIK3CA, PIK3R1, PIK3CG, RECK, CNTF, PCK2
11polysaccharide32 19.3NCOA3, RECK, SFTPD, SELE, SELL, SELP
12gtp32 19.1PIK3CA, PIK3R1, PIK3C2A, PDE3B, RECK, CNR2
13homocysteine32 18 19.6PIK3C2A, COG2, RETN, VWF, SELE, SELP
14carnitine32 18.3PC, PCK2, PCK1, LPL, LIPE, CHKB
15corticosterone32 18 18.9CNR1, PCK2, GCG, SERPINA6, VIP, LIF
16nacl32 17.8REN, VDAC1, LIF, LIPC, BDNF, CHKB
17dhea32 17.6RETN, SERPINA6, KCNMA1, LEP, LCAT, IRS2
18carbohydrates32 17.2RECK, SFTPD, SELE, SELL, SELP, SERPINA6
19adenine32 9 18 9 19.3PDE3B, VWF, MYB, ZFP36, KCNJ11, LEP
20sodium dodecylsulfate32 16.3LRP1, VWF, SERPINF2, SERPINE1, LPA, LPL
21gp 13032 15.6PIK3R1, RECK, CNTF, CNTFR, VIP, BMP4
22histidine32 15.5PDE3B, RARA, LIPF, KCNJ11, SCD5, SCG5
23pge132 15.5PIK3C2A, PDE3B, VWF, SELL, SERPINE1, VIP
24herbimycin a32 42 16.0PIK3CG, SELE, SELL, VCAM1, BMP6, JUN
25dmso32 14.8SELP, BMP6, BDKRB2, SDHB, CHGA, S100A9
26progestins32 14.6SERPINA6, LIF, LIPC, JAK2, MMP3, AR
27arsenite32 18 15.5PIK3CA, PIK3R1, PIK3CG, PCNA, VEGFA, VDR
288-isoprostane32 14.5RETN, SELE, SERPINE1, VCAM1, LEP, SAA4
29rifampicin32 14.3INHA, GPT, IAPP, HP, HNF4A, CYP7A1
30fructose32 9 9 16.3PC, PCK2, GCK, GCG, GCGR, SDHB
31capsaicin32 14.1CNR1, SELE, VIP, BDNF, LEP, CDKN3
32l-nmma32 14.0VIP, VCAM1, BDKRB2, KCNMA1, XDH, INSR
33chloroquine32 34 9 9 16.9SERPINC1, BMP6, CIITA, LDLR, BACE1, B2M
34bromocriptine32 9 9 15.8PIK3C2A, VIP, HTR1A, HTR2A, HTR2C, GNRH1
35methimazole32 9 9 15.7VWF, PCNA, SELE, SELL, BGLAP, LDLR
36candesartan32 9 9 15.7REN, SELP, SERPINE1, VEGFA, BDKRB2, MMP2
37telmisartan32 9 9 15.6COG2, REN, LEP, INS, ALB, CYP2C19
38naloxone32 34 9 9 16.6CNR1, VIP, KCNJ5, LEP, CGA, FOS
39erythromycin32 9 9 15.5PIK3C2A, VIP, VCAM1, MSRA, MPO, ITGB2
40cerivastatin32 9 9 15.5PIK3C2A, COG2, REN, SERPINE1, BMP2, RAC1
41il 1032 13.5VDR, BMP6, LIF, LBP, IL10, IL10RA
42methacholine32 9 9 15.4PDE3B, REN, VIP, KCNJ5, KCNMA1, MPO
43deoxypyridinoline32 13.1VDR, BGLAP, PAX5, CD36, MMP3, IL11
44polymyxin b32 13.0SELE, SERPINE1, VDAC1, VCAM1, BPI, LDLR
45txb232 12.9RECK, REN, VWF, SELP, SERPINF2, LPA
46azathioprine32 34 9 9 15.9PCNA, BMP2, BMP4, RARB, RAC1, LIF
47ionomycin32 12.8PIK3CB, KCNMA1, CHUK, CD2, CDK4, FOS
48n-formylmethionyl-leucylphenylalanine32 12.7PIK3CG, SELL, SELP, LCN2, MPO, ITGAM
49bleomycin32 9 9 14.0CDKN3, CD44, GSTM1, GSTP1, FGF2, IL2RA
50magnesium32 9 18 9 INFPIK3C2A, PC, GCK, GC, RBP4, BPI

GO Terms for genes affiliated with Obesity

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Sources:
12Gene Ontology
See all sources

Cellular components related to obesity according to GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:005886INFPIK3R1, PIK3C2A, PIK3CG, , LRP5, RFTN1
2cytoplasmGO:005737INFZNF318, PIK3C2A, PIK3CG, PID1, LRP1, SH3BGRL
3integral to plasma membraneGO:00588728.0LRP1, NCR3, CNR1, CNR2, KIR2DL1, KIR2DL3
4secretory granuleGO:03014114.9PCSK2, PCSK1, GCK, GCG, VEGFA, SCG5
5neuronal cell bodyGO:04302514.5CNTF, PCSK1, BRS3, BMPR1A, BMPR2, UCHL1
6external side of plasma membraneGO:00989714.1VWF, SELL, SELP, VCAM1, KCNJ5, LDLR
7platelet alpha granule lumenGO:03109313.2VWF, SERPINF2, SERPINE1, VEGFA, VEGFC, CLU
8high-density lipoprotein particleGO:03436412.9LIPC, LCAT, SAA1, SAA2, SAA4, CETP
9caveolaGO:00590112.5SELE, BMPR1A, BMPR2, LIPE, KCNMA1, SCARB1
10extracellular regionGO:005576INFRETN, KISS1, VWF, SFTPD, GCG, GC
11extracellular spaceGO:005615INFREG3A, REN, CNTF, SFTPD, PCSK9, PCSK2
12cytosolGO:005829INFPIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, SH2B1
13cell surfaceGO:009986INFPCSK9, VEGFA, LPL, VCAM1, BMP2, BMPR2

Biological processes related to obesity according to GeneDecks:

(show top 50)    (show all 68)
idNameGO IDScoreTop Affiliating Genes
1fat cell differentiationGO:045444INFPID1, BBS2, BBS4, BBS7, , FOXO1
2positive regulation of transcription, DNA-dependentGO:045893INFLRP5, NCOA3, RELA, MYB, BMP2, BMP4
3positive regulation of cell proliferationGO:008284INFLRP5, CNTF, CNTFR, BTC, VIP, NAMPT
4signal transductionGO:007165INFPIK3CB, PDE10A, CNTF, CNTFR, GCG, NAMPT
5positive regulation of transcription from RNA polymerase II promoterGO:04594422.6PID1, LRP5, NCOA3, RELA, SERPINF2, SERPINE1
6G-protein coupled receptor signaling pathwayGO:00718620.8PIK3CB, PIK3CG, KISS1, GCG, VIP, CMKLR1
7inflammatory responseGO:00695419.4PIK3CG, NCR3, RELA, CNR2, SELE, SELP
8cell-cell signalingGO:00726718.8PCSK1, NAMPT, BMP2, S100A9, XCL1, CGA
9lipid metabolic processGO:00662918.2PC, LPA, LPIN2, LPL, LIPE, CLU
10immune responseGO:00695518.1NCR3, CNR2, KIR2DL1, KIR2DL3, KIR3DL1, BPI
11response to hypoxiaGO:00166617.5VEGFA, VCAM1, BMP2, CLDN3, KCNMA1, LEP
12cellular lipid metabolic processGO:04425516.8NCOA3, NCOR2, LPIN1, LPIN2, CD36, FDFT1
13platelet activationGO:03016816.6PIK3CB, PIK3CA, PIK3R1, PIK3CG, VWF, SELP
14glucose homeostasisGO:04259316.5PDE3B, PCK1, GCK, RBP4, SERPINE1, PAX6
15glucose metabolic processGO:00600616.4PIK3CA, PC, PCK2, PCK1, SERPINA12, BRS3
16negative regulation of cell proliferationGO:00828516.3VDR, BMP2, BMP4, RARG, RARB, LIF
17response to glucocorticoid stimulusGO:05138416.0PCK2, PCSK1, SERPINF1, SERPINE1, BGLAP, BCHE
18response to glucose stimulusGO:00974915.5PCSK1, IRS2, INSR, APOA2, APOM, ANGPT2
19insulin receptor signaling pathwayGO:00828615.4PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PDE3B, NAMPT
20cellular response to insulin stimulusGO:03286915.4PDE3B, PCSK9, GCK, IRS1, IRS2, INHBB
21response to lipopolysaccharideGO:03249615.3CNR1, CNR2, PCSK1, SELE, SELP, LBP
22cholesterol homeostasisGO:04263215.2LRP5, PCSK9, LIPC, SCARB1, LDLR, LCAT
23response to insulin stimulusGO:03286815.0PCK1, RBP4, LEP, UCP3, IRS1, AR
24female pregnancyGO:00756515.0GC, LIPE, PAPPA, LEP, UCN, FLT1
25cholesterol metabolic processGO:00820315.0PCSK9, LIPE, LIPC, LEP, LEPR, LDLR
26feeding behaviorGO:00763114.9GCG, BDNF, MC4R, MCHR1, CCKBR, CCKAR
27elevation of cytosolic calcium ion concentrationGO:00720414.9GCK, LPAR3, BDKRB2, SAA1, JAK2, ITPR3
28response to ethanolGO:04547114.5CNR1, RBP4, BGLAP, LCT, S100A8, S100A9
29agingGO:00756814.5CNR1, SERPINF1, VDR, VCAM1, UCP3, MSRA
30lipoprotein metabolic processGO:04215714.5PCSK9, LPA, LPL, SCARB1, LDLR, LCAT
31positive regulation of angiogenesisGO:04576614.3SERPINE1, VEGFA, CHI3L1, MMP9, ISL1, FLT1
32platelet degranulationGO:00257614.3VWF, SELP, SERPINF2, SERPINE1, VEGFA, VEGFC
33positive regulation of apoptotic processGO:04306514.3CNR1, BMP2, BMP4, RARG, RARB, CLU
34regulation of blood pressureGO:00821714.1LRP5, REN, GCGR, BRS3, LEP, CHGA
35response to nutrientGO:00758413.9CNR1, GCGR, SERPINC1, VCAM1, UCP3, LCT
36G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718713.6CNR1, CNR2, LPAR3, MTNR1A, MTNR1B, MC1R
37response to organic cyclic compoundGO:01407013.5SELP, BMP4, JUN, IL1A, IL1RN, IL4
38triglyceride metabolic processGO:00664113.4PCSK9, LPL, LIPF, CETP, INSIG1, INSIG2
39positive regulation of peptidyl-tyrosine phosphorylationGO:05073113.3VEGFA, LIF, MTOR, JAK2, CD36, CD44
40phosphatidylinositol-mediated signalingGO:04801512.3PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PCNA, CHUK
41response to drugGO:042493INFREN, PCSK1, VEGFC, LPL, LIPE, BGLAP
42nerve growth factor receptor signaling pathwayGO:048011INFPIK3CB, PIK3CA, PIK3R1, RELA, RAC1, CHUK
43energy reserve metabolic processGO:006112INFPID1, PCSK1, GCG, GCGR, KCNJ11, LEP
44small molecule metabolic processGO:044281INFPIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, NCOA3
45negative regulation of apoptotic processGO:043066INFPIK3CG, RELA, GCG, BTC, SERPINE1, VEGFA
46blood coagulationGO:007596INFPIK3CB, PIK3CA, PIK3R1, PIK3CG, SH2B1, PDE10A
47negative regulation of transcription from RNA polymerase II promoterGO:000122INFNCOR2, VDR, MYB, BMP2, BMP4, RARG
48anti-apoptosisGO:006916INFPIK3CA, RELA, BDNF, UBB, CEBPB, MPO
49regulation of insulin secretionGO:050796INFCNR1, PCSK1, GCK, GCG, KCNJ11, LEP
50positive regulation of cell migrationGO:030335INFVEGFA, BMP2, CGA, JAK2, ITGAV, MMP14

Molecular functions related to obesity according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:04280320.1ACHE, HMOX1, GHR, HNF4A, HNF1B, HNF1A
2receptor bindingGO:00510219.8AR, LEPROT, CLCF1, LIF, RARRES2, RARA
3hormone activityGO:00517917.0HAMP, EDN1, CRHR2, CRH, PPY, SST
4cytokine activityGO:00512516.2GDF3, GDF15, ADIPOQ, CSF3, CSF2, CNTF
5growth factor activityGO:00808314.5GDF3, NGF, GH1, F2, IGF1, IGF2
6enzyme bindingGO:01989913.2PPARG, CTNNBL1, CYP2E1, CYP2C19, CYP2A6, CYP3A4
7steroid hormone receptor activityGO:00370712.9NR1H4, NR1H3, NR1H2, NR0B2, NR3C2, RXRA
8protein heterodimerization activityGO:046982INFTGFB1, TFAP2B, TAS1R2, SOX6, TWIST1, AGTR1
9protein bindingGO:005515INFROBO1, NPB, POU2F1, CST3, CSF2, SOX6

Sources for Obesity

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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