MCID: OBS005
MIFTS: 98

Obesity malady

Genetic diseases, Rare diseases, Metabolic diseases categories

Summaries for Obesity

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MedlinePlus:34 Obesity means having too much body fat. it is different from being overweight, which means weighing too much. the weight may come from muscle, bone, fat, and/or body water. both terms mean that a person's weight is greater than what's considered healthy for his or her height. obesity occurs over time when you eat more calories than you use. the balance between calories-in and calories-out differs for each person. factors that might affect your weight include your genetic makeup, overeating, eating high-fat foods, and not being physically active. being obese increases your risk of diabetes, heart disease, stroke, arthritis, and some cancers. if you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases. for example, that means losing 10 to 20 pounds if you weigh 200 pounds. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Obesity, also known as obesity, severe, and type ii diabetes, is related to morbid obesity and polycystic ovary syndrome, and has symptoms including obesityand abnormality of metabolism/homeostasis. An important gene associated with Obesity is PPARG (peroxisome proliferator-activated receptor gamma), and among its related pathways are Signaling by GPCR and Metabolism. The drugs benzphetamine and phenylpropanolamine hydrochloride and the compounds glucose and lipid have been mentioned in the context of this disorder. Affiliated tissues include liver, ovary and skeletal muscle, and related mouse phenotypes are homeostasis/metabolism and adipose tissue.

Wikipedia:65 Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a... more...

Descriptions from OMIM:47 601665,607514

Aliases & Classifications for Obesity

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Obesity, Aliases & Descriptions:

Name: Obesity 47 32 10 43 22 45 24 34 62
Obesity, Severe, and Type Ii Diabetes 47 32
Obesity, Autosomal Dominant 47 11
Body Mass Index Quantitative Trait Locus 10 47
Obesity, Mild, Early-Onset 47
 
Obesity, Association with 47
Obesity, Variation in 47
Obesity, Early-Onset 47
Obesity, Late-Onset 47
Obesity, Severe 47


Classifications:



External Ids:

Disease Ontology10 DOID:9970
ICD9CM29 278.00
NCIt40 C3283
MeSH35 D009765
ICD1027 E66

Related Diseases for Obesity

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Diseases in the Obesity family:

Obesity, Mc4r-Related Obesity, Pparg-Related
Obesity, Susceptibility to, Cartpt-Related Obesity, Susceptibility to, Mc3r-Related
Obesity, Ucp3-Related Obesity, Pyy-Related
Obesity, Sim1-Related

Diseases related to Obesity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 725)
idRelated DiseaseScoreTop Affiliating Genes
1morbid obesity31.9GHRL, ADRB3, MC4R, PYY
2polycystic ovary syndrome31.5GHRL, ADRB3, POMC, PPARG
3eating disorder31.2AGRP, GHRL, MC4R, PYY
4glucose intolerance31.2GHRL, PYY
5prader-willi syndrome31.1PYY, GHRL, AGRP
6atherosclerosis31.1PPARG, ADRB3, ADRB2, GHRL, UCP3, UCP1
7hyperandrogenism31.0POMC, MC4R, PPARG
8anorexia nervosa30.9PYY, MC4R, POMC, GHRL, AGRP
9hyperglycemia30.8ENPP1, GHRL, ADRB3, POMC, PYY, PPARG
10hyperinsulinism30.8GHRL, MC4R, PPARG
11hypothyroidism30.6AGRP, GHRL, POMC
12metabolic syndrome x30.6PPARG, POMC, ADRB3, ADRB2, GHRL, UCP3
13coronary artery disease30.6PPARG, ADRB3, ADRB2, GHRL, ENPP1
14bulimia nervosa30.6MC4R, GHRL
15growth hormone deficiency30.4POMC, GHRL
16hypoglycemia30.4GHRL, ADRB2, POMC
17hypopituitarism30.3POMC, GHRL
18adenoma30.3PPARG, PYY, POMC, GHRL
19lipid metabolism disorder30.1ADRB2, ADRB3, PPARG
20diabetes mellitus, noninsulin-dependent29.7PPARG, PYY, MC4R, ADRB3, ADRB2, GHRL
21pheochromocytoma29.7UCP1, ADRB2, POMC, PYY
22diabetes mellitus, insulin-dependent29.7ADRB3, ADRB2, UCP1, ENPP1
23pituitary tumors29.7GHRL, POMC, PPARG
24pituitary adenoma29.7PPARG, POMC, GHRL
25acth deficiency29.7POMC, MC4R
26adrenal gland hyperfunction29.7GHRL, POMC
27liver disease10.8
28hepatitis10.8
29fatty liver disease10.8
30sleep apnea10.6
31endotheliitis10.6
32acanthosis nigricans10.6
33obstructive sleep apnea10.6
34breast cancer10.6
35pancreatitis10.6
36asthma10.5
37hypertriglyceridemia10.5
38thyroiditis10.5
39nonalcoholic steatohepatitis10.5
40craniopharyngioma10.5
41hypogonadism10.5
42prostatitis10.5
43insulin-like growth factor i10.5
44esophagitis10.5
45blindness10.5
46adenocarcinoma10.4
47kidney disease10.4
48prostate cancer10.4
49gastroesophageal reflux10.4
50bardet-biedl syndrome10.4

Graphical network of the top 20 diseases related to Obesity:



Diseases related to obesity

Symptoms for Obesity

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Symptoms by clinical synopsis from OMIM:

601665

Clinical features from OMIM:

601665,607514

HPO human phenotypes related to Obesity:

id Description Frequency HPO Source Accession
1 obesity HP:0001513
2 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Obesity

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Genetic Tests for Obesity

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Genetic tests related to Obesity:

id Genetic test Affiliating Genes
1 Obesity22 24

Anatomical Context for Obesity

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MalaCards organs/tissues related to Obesity:

33
Liver, Ovary, Skeletal muscle, Heart, Adipocyte, Bone, Kidney, Breast, Endothelial, Testes, Brain, Thyroid, Pituitary, Prostate, Monocytes, T cells, Colon, Skin, Lung, Neutrophil, Hypothalamus, B cells, Smooth muscle, Pancreatic islet, Pancreas, Spinal cord, Myeloid, Salivary gland, Bone marrow, Lymph node, Small intestine, Placenta, Testis, Amygdala, Whole blood, Spleen, Thymus, Cortex, Cerebellum, Retina, Nk cells, Pons, Tongue, Adrenal cortex

Animal Models for Obesity or affiliated genes

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Publications for Obesity

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Articles related to Obesity:

(show top 50)    (show all 9089)
idTitleAuthorsYear
1
Perceived weight in youths and risk of overweight or obesity six years later. (24360137)
2014
2
MicroRNA Functions in Brite/Brown Fat - Novel Perspectives towards Anti-Obesity Strategies. (25408843)
2014
3
Body Mass Index Categories and Mortality Risk in US Adults: The Effect of Overweight and Obesity on Advancing Death. (24432921)
2014
4
Substantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder. (23639407)
2013
5
Family Structure and Childhood Obesity: An Analysis Through 8th Grade. (24370680)
2013
6
Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children. (23510779)
2013
7
Influence of attention-deficit/hyperactivity disorder on binge eating behaviors and psychiatric comorbidity profile of obese women. (24246603)
2013
8
Surgically induced interpregnancy weight loss and prevalence of overweight and obesity in offspring. (24349234)
2013
9
Cystic fibrosis: from protein-energy malnutrition to obesity with dyslipidemia. (24800027)
2013
10
Uncoupling protein-2 45-base pair insertion/deletion polymorphism: is there an association with severe obesity and weight loss in morbidly obese subjects? (22568573)
2012
11
Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China. (21892197)
2011
12
GPR43: an emerging target for the potential treatment of type 2 diabetes, obesity and insulin resistance. (20336586)
2010
13
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
14
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch. (20492663)
2010
15
Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes. (19558533)
2010
16
Hypothalamic obesity complicated by adipsic central diabetes insipidus following surgical resection of a craniopharyngioma. (19817945)
2009
17
Obesity and polycystic ovary syndrome. (20054201)
2009
18
Evaluation of bone disease in morbidly obese women after gastric bypass and risk factors implicated in bone loss. (19412643)
2009
19
Obesity alters cytokine gene expression and promotes liver injury in rats with acute pancreatitis. (18223607)
2008
20
The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. (18295974)
2008
21
Metabolic effects of weight loss on a very-low-carbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects. (18174038)
2008
22
Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) study. (18452784)
2008
23
The preservation of insulin sensitivity in obese women without diabetes. (18672628)
2008
24
Double-blind, randomized trial comparing efficacy and safety of continuing olanzapine versus switching to quetiapine in overweight or obese patients with schizophrenia or schizoaffective disorder. (19209252)
2008
25
Novel melanocortin 4 receptor gene mutations in severely obese children. (17941900)
2008
26
Fibrinogen, plasma viscosity and blood viscosity in obesity. Relationship with insulin resistance. (17942983)
2007
27
Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in utah. (16741266)
2006
28
Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. (17065359)
2006
29
Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome. (16077717)
2005
30
Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. (15975705)
2005
31
Superior mesenteric artery syndrome after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (15329194)
2004
32
Addition of rosiglitazone to metformin is most effective in obese, insulin-resistant patients with type 2 diabetes. (12681023)
2003
33
Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses. (12960083)
2003
34
Weight loss in a patient with morbid obesity under treatment with oleoyl-estrone]. (14588193)
2003
35
Central and peripheral glucocorticoid receptor function in abdominal obesity. (11936464)
2002
36
Resistin, obesity and insulin resistance--the emerging role of the adipocyte as an endocrine organ. (11794158)
2001
37
Overweight/obesity, smoking, and heavy alcohol consumption are important determinants of plasma PAI-1 levels in healthy men. (11465242)
2001
38
Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women. (11157312)
2001
39
A cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats. (10958832)
2000
40
Effect of opioid blockade on insulin and growth hormone (GH) secretion in patients with polycystic ovary syndrome: the heterogeneity of impaired GH secretion is related to both obesity and hyperinsulinism. (9935127)
1999
41
The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk. (9569171)
1998
42
A case of acanthosis nigricans in obese siblings with a pedigree of familial polyposis coli. (9330076)
1997
43
The beta(3)-adrenergic receptor TRP64ARG polymorphism and obesity in Alaskan Eskimos. (9426386)
1997
44
Determinants of the kinetics of very low-density lipoprotein apolipoprotein B-100 in non-obese men. (9269527)
1997
45
Pseudotumor cerebri in a patient with Bartter's syndrome and obesity. (8903869)
1996
46
Lipoprotein lipase gene polymorphisms: associations with hypertriglyceridemia and body mass index in obese people. (7627251)
1995
47
Hormones and obesity. (7980347)
1994
48
Arginine potentiates but does not restore the blunted growth hormone response to growth hormone-releasing hormone in obesity. (1588839)
1992
49
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. (1955512)
1991
50
Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats. (1939742)
1991

Variations for Obesity

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UniProtKB/Swiss-Prot genetic disease variations for Obesity:

64 (show all 30)
id Symbol AA change Variation ID SNP ID
1MC4Rp.Ser30ArgVAR_010704
2MC4Rp.Asp37ValVAR_010705rs13447325
3MC4Rp.Pro78LeuVAR_010706rs13447326
4MC4Rp.Arg165TrpVAR_010709rs13447332
5MC4Rp.Gly252SerVAR_010711rs13447336
6MC4Rp.Ile317ThrVAR_010712rs13447337
7MC4Rp.Asn274SerVAR_015357
8MC4Rp.Thr11AlaVAR_038632
9MC4Rp.Ser36TyrVAR_038633
10MC4Rp.Val50MetVAR_038634
11MC4Rp.Ser58CysVAR_038635
12MC4Rp.Asn62SerVAR_038636
13MC4Rp.Asn97AspVAR_038638
14MC4Rp.Ile102SerVAR_038639
15MC4Rp.Ile102ThrVAR_038640
16MC4Rp.Leu106ProVAR_038641
17MC4Rp.Ile125LysVAR_038642
18MC4Rp.Ser127LeuVAR_038643rs13447331
19MC4Rp.Arg165GlnVAR_038644rs13447332
20MC4Rp.Ile170ValVAR_038645rs121913560
21MC4Rp.Ala175ThrVAR_038646
22MC4Rp.Gly181AspVAR_038647rs13447333
23MC4Rp.Ala219ValVAR_038648
24MC4Rp.Val253IleVAR_038650rs187152753
25MC4Rp.Cys271ArgVAR_038651
26MC4Rp.Cys271TyrVAR_038652
27MC4Rp.Ile316SerVAR_038653
28MC4Rp.Leu325PheVAR_038654
29PPARGp.Pro113GlnVAR_010724rs1800571
30UCP3p.Val102IleVAR_004408rs2229707

Clinvar genetic disease variations for Obesity:

7 (show all 40)
id Gene Variation Type Significance SNP ID Assembly Location
1ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
2ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
3ENPP1NM_006208.2(ENPP1): c.*1043A> Gsingle nucleotide variantrisk factorrs7754561GRCh37Chr 6, 132212694: 132212694
4MC4RMC4R, 4-BP DEL, NT631deletionPathogenic
5MC4RMC4R, 4-BP INS, NT732insertionPathogenic
6MC4RNM_005912.2(MC4R): c.105C> A (p.Tyr35Ter)single nucleotide variantPathogenicrs13447324GRCh37Chr 18, 58039478: 58039478
7MC4RNM_005912.2(MC4R): c.110A> T (p.Asp37Val)single nucleotide variantPathogenicrs13447325GRCh37Chr 18, 58039473: 58039473
8MC4RNM_005912.2(MC4R): c.148G> A (p.Val50Met)single nucleotide variantPathogenicrs121913557GRCh37Chr 18, 58039435: 58039435
9MC4RNM_005912.2(MC4R): c.172A> T (p.Ser58Cys)single nucleotide variantPathogenicrs121913558GRCh37Chr 18, 58039411: 58039411
10MC4RNM_005912.2(MC4R): c.305T> G (p.Ile102Ser)single nucleotide variantPathogenicrs121913559GRCh37Chr 18, 58039278: 58039278
11MC4RNM_005912.2(MC4R): c.508A> G (p.Ile170Val)single nucleotide variantPathogenicrs121913560GRCh37Chr 18, 58039075: 58039075
12MC4RNM_005912.2(MC4R): c.821A> G (p.Asn274Ser)single nucleotide variantPathogenicrs121913561GRCh37Chr 18, 58038762: 58038762
13MC4RMC4R, 1-BP INS, 112AinsertionPathogenic
14MC4RMC4R, 4-BP DEL, 211CTCTdeletionPathogenic
15MC4RMC4R, 2-BP INS, 279GTinsertionPathogenic
16MC4RMC4R, ILE125LYSundetermined variantPathogenic
17MC4RNM_005912.2(MC4R): c.812G> A (p.Cys271Tyr)single nucleotide variantPathogenicrs121913562GRCh37Chr 18, 58038771: 58038771
18MC4RNM_005912.2(MC4R): c.523G> A (p.Ala175Thr)single nucleotide variantPathogenicrs121913563GRCh37Chr 18, 58039060: 58039060
19MC4RNM_005912.2(MC4R): c.947T> G (p.Ile316Ser)single nucleotide variantPathogenicrs121913564GRCh37Chr 18, 58038636: 58038636
20MC4RNM_005912.2(MC4R): c.861T> A (p.Tyr287Ter)single nucleotide variantPathogenicrs121917829GRCh37Chr 18, 58038722: 58038722
21MC4RNM_005912.2(MC4R): c.289A> G (p.Asn97Asp)single nucleotide variantPathogenicrs121913565GRCh37Chr 18, 58039294: 58039294
22MC4RNM_005912.2(MC4R): c.185A> G (p.Asn62Ser)single nucleotide variantPathogenicrs121913566GRCh37Chr 18, 58039398: 58039398
23MC4RMC4R, 15-BP DELdeletionPathogenic
24MC4RNM_005912.2(MC4R): c.380C> T (p.Ser127Leu)single nucleotide variantPathogenicrs13447331GRCh37Chr 18, 58039203: 58039203
25MC4RMC4R, 2-BP DEL, 750GAdeletionPathogenic
26MC4RNM_005912.2(MC4R): c.656C> T (p.Ala219Val)single nucleotide variantPathogenicrs121913567GRCh37Chr 18, 58038927: 58038927
27ADRB3NM_000025.2(ADRB3): c.190T> C (p.Trp64Arg)single nucleotide variantrisk factorrs4994GRCh37Chr 8, 37823798: 37823798
28ADRB2NM_000024.5(ADRB2): c.79C> G (p.Gln27Glu)single nucleotide variantrisk factorrs1042714GRCh37Chr 5, 148206473: 148206473
29FFAR4NM_181745.3(FFAR4): c.809G> A (p.Arg270His)single nucleotide variantrisk factorrs116454156GRCh37Chr 10, 95347041: 95347041
30LEPRNM_002303.5(LEPR): c.2880C> G (p.Asn960Lys)single nucleotide variantLikely pathogenicrs193922650GRCh37Chr 1, 66102080: 66102080
31MC4RNM_005912.2(MC4R): c.538T> C (p.Ser180Pro)single nucleotide variantLikely pathogenicrs193922685GRCh37Chr 18, 58039045: 58039045
32MC4RNM_005912.2(MC4R): c.806T> A (p.Ile269Asn)single nucleotide variantLikely pathogenicrs79783591GRCh37Chr 18, 58038777: 58038777
33MC4RNM_005912.2(MC4R): c.835_836dupTG (p.Phe280Alafs)duplicationPathogenicrs193922687GRCh37Chr 18, 58038746: 58038747
34MC4RNM_005912.2(MC4R): c.896C> A (p.Pro299His)single nucleotide variantPathogenicrs52804924GRCh37Chr 18, 58038687: 58038687
35NM_001134944.1(GHRL): c.116G> A (p.Arg39Gln)single nucleotide variantrisk factorrs34911341GRCh37Chr 3, 10331519: 10331519
36NM_001134944.1(GHRL): c.233A> T (p.Gln78Leu)single nucleotide variantrisk factorrs4684677GRCh37Chr 3, 10328453: 10328453
37MRAP2NM_138409.2(MRAP2): c.70G> T (p.Glu24Ter)single nucleotide variantrisk factorGRCh37Chr 6, 84765107: 84765107
38CARTPTNM_004291.3(CARTPT): c.183G> C (p.Leu61Phe)single nucleotide variantrisk factorrs121909065GRCh37Chr 5, 71015730: 71015730
39PYYNM_004160.4(PYY): c.185A> C (p.Gln62Pro)single nucleotide variantrisk factorrs267606994GRCh37Chr 17, 42030667: 42030667
40MT-CYBm.15497G> Asingle nucleotide variantrisk factorrs199951903GRCh37Chr MT, 15497: 15497

Expression for genes affiliated with Obesity

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LifeMap Discovery
Genes differentially expressed in tissues of Obesity patients vs. healthy controls: 32 (show all 314)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1SLNsarcolipinSkeletal Muscle-4.170.031
2GAPDHglyceraldehyde-3-phosphate dehydrogenaseSkeletal Muscle-4.140.045
3MYOTmyotilinLiver-3.660.000
4AZGP1alpha-2-glycoprotein 1, zinc-bindingAdipose-3.650.000
5RPL41ribosomal protein L41Skeletal Muscle-3.560.040
6IL17RCinterleukin 17 receptor CLiver+3.520.002
7CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 9Liver-3.460.001
8GREB1growth regulation by estrogen in breast cancer 1Liver-3.300.009
9IGHMimmunoglobulin heavy constant muLiver+3.290.003
10ZFP36L2ZFP36 ring finger protein-like 2Liver+3.090.019
11TTNtitinSkeletal Muscle-3.030.043
12HUWE1HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligaseSkeletal Muscle-2.990.048
13NUDT4nudix (nucleoside diphosphate linked moiety X)-type motif 4Liver-2.970.006
14NDUFA2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDaLiver-2.960.003
15GPM6Bglycoprotein M6BLiver-2.890.018
16ABHD6abhydrolase domain containing 6Liver-2.880.002
17CALM1calmodulin 1 (phosphorylase kinase, delta)Liver-2.860.000
18UBCubiquitin CSkeletal Muscle-2.850.048
19PRMT3protein arginine methyltransferase 3Liver-2.850.006
20IGFBP1insulin-like growth factor binding protein 1Liver-2.820.025
21JUNDjun D proto-oncogeneLiver+2.800.010
22KIAA0754KIAA0754Liver-2.790.012
23RPL23Aribosomal protein L23aSkeletal Muscle-2.710.028
24METTL5methyltransferase like 5Liver-2.690.034
25GOLPH3Lgolgi phosphoprotein 3-likeLiver-2.640.010
26CA3carbonic anhydrase III, muscle specificAdipose-2.630.010
27GREB1growth regulation by estrogen in breast cancer 1Liver-2.630.032
28ALDOAaldolase A, fructose-bisphosphateLiver+2.620.029
29SP100SP100 nuclear antigenLiver-2.620.021
30MCF2MCF.2 cell line derived transforming sequenceLiver-2.620.036
31UGT2B15UDP glucuronosyltransferase 2 family, polypeptide B15Liver-2.560.007
32POU3F3POU class 3 homeobox 3Liver-2.560.026
33BCAP29B-cell receptor-associated protein 29Liver-2.520.012
34IRAK3interleukin-1 receptor-associated kinase 3Liver-2.520.002
35DKK3dickkopf WNT signaling pathway inhibitor 3Liver-2.510.034
36PSIP1PC4 and SFRS1 interacting protein 1Liver-2.500.003
37MVKmevalonate kinaseLiver+2.460.032
38TNNC2troponin C type 2 (fast)Skeletal Muscle-2.460.044
39MRPL42mitochondrial ribosomal protein L42Liver-2.460.045
40CLDN3claudin 3Liver+2.450.023
41ARPC4actin related protein 2/3 complex, subunit 4, 20kDaLiver+2.440.027
42ARHGEF26Rho guanine nucleotide exchange factor (GEF) 26Liver-2.430.040
43CDHR5cadherin-related family member 5Liver+2.420.047
44HLA-DQB1major histocompatibility complex, class II, DQ beta 1Liver-2.410.014
45PLECplectinLiver+2.380.028
46MYOTmyotilinLiver-2.370.046
47PPP1R3Aprotein phosphatase 1, regulatory subunit 3ALiver-2.370.040
48DLX5distal-less homeobox 5Liver-2.360.050
49NINJ2ninjurin 2Liver-2.350.033
50C6orf62chromosome 6 open reading frame 62Liver-2.340.001
51PSG5pregnancy specific beta-1-glycoprotein 5Liver-2.300.037
52CNGB1cyclic nucleotide gated channel beta 1Liver-2.290.021
53TPSAB1tryptase alpha/beta 1Liver+2.290.035
54HTR1B5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupledLiver-2.290.028
55DESdesminLiver-2.280.025
56DHPSdeoxyhypusine synthaseLiver+2.270.033
57EMP3epithelial membrane protein 3Adipose+2.270.014
58BAXBCL2-associated X proteinLiver+2.260.009
59DNAH9dynein, axonemal, heavy chain 9Liver+2.250.005
60PRPF4pre-mRNA processing factor 4Liver+2.250.011
61FASTKFas-activated serine/threonine kinaseLiver+2.250.019
62TRIM10tripartite motif containing 10Blood+2.250.001
63PPP4Cprotein phosphatase 4, catalytic subunitLiver+2.240.017
64TFDP2transcription factor Dp-2 (E2F dimerization partner 2)Liver+2.240.043
65RBM19RNA binding motif protein 19Liver+2.240.001
66F13A1coagulation factor XIII, A1 polypeptideAdipose+2.230.001
67CTGFconnective tissue growth factorAdipose+2.230.000
68VCANversicanAdipose+2.230.012
69ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)Adipose+2.230.005
70TNFSF4tumor necrosis factor (ligand) superfamily, member 4Liver-2.230.026
71EFCAB11EF-hand calcium binding domain 11Liver+2.230.041
72GDF2growth differentiation factor 2Liver+2.220.002
73PEX1peroxisomal biogenesis factor 1Adipose-2.210.004
74HBDhemoglobin, deltaLiver+2.210.004
75TREHtrehalase (brush-border membrane glycoprotein)Liver+2.210.040
76PTX3pentraxin 3, longAdipose+2.210.003
77GNASGNAS complex locusLiver+2.200.015
78GTF2F1general transcription factor IIF, polypeptide 1, 74kDaLiver+2.200.044
79SERPINB4serpin peptidase inhibitor, clade B (ovalbumin), member 4Liver-2.200.048
80KIFC3kinesin family member C3Liver+2.200.011
81QTRT1queuine tRNA-ribosyltransferase 1Liver+2.190.049
82THOC6THO complex 6 homolog (Drosophila)Liver+2.180.020
83NOL8nucleolar protein 8Liver-2.180.038
84TMEM121transmembrane protein 121Liver+2.180.003
85XKX-linked Kx blood group (McLeod syndrome)Blood+2.180.001
86RRBP1ribosome binding protein 1Liver+2.170.003
87CD14CD14 moleculeAdipose+2.170.003
88ABCA2ATP-binding cassette, sub-family A (ABC1), member 2Liver+2.170.005
89INSM1insulinoma-associated 1Liver-2.170.028
90FASTKFas-activated serine/threonine kinaseLiver+2.170.040
91CHRNA4cholinergic receptor, nicotinic, alpha 4 (neuronal)Liver+2.160.035
92DHPSdeoxyhypusine synthaseLiver+2.160.020
93UBE2Mubiquitin-conjugating enzyme E2MLiver+2.150.028
94NRIP2nuclear receptor interacting protein 2Liver+2.150.028
95AMDHD2amidohydrolase domain containing 2Liver+2.150.028
96ACTA1actin, alpha 1, skeletal muscleLiver+2.150.028
97RYKreceptor-like tyrosine kinaseLiver+2.140.028
98DLATdihydrolipoamide S-acetyltransferaseLiver+2.130.009
99HGC6.3uncharacterized LOC100128124Liver+2.130.024
100PTPRCprotein tyrosine phosphatase, receptor type, CAdipose+2.130.000
101SMPD1sphingomyelin phosphodiesterase 1, acid lysosomalLiver+2.120.011
102HABP4hyaluronan binding protein 4Liver+2.120.019
103PDK2pyruvate dehydrogenase kinase, isozyme 2Liver+2.120.045
104SEMA6Bsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6BLiver+2.110.018
105C1orf56chromosome 1 open reading frame 56Liver-2.110.016
106TMEM194Atransmembrane protein 194ALiver-2.100.020
107IFI30interferon, gamma-inducible protein 30Adipose+2.100.001
108FECHferrochelataseBlood+2.090.003
109RNF41ring finger protein 41, E3 ubiquitin protein ligaseLiver-2.090.000
110CXCL2chemokine (C-X-C motif) ligand 2Adipose+2.080.028
111S100A1S100 calcium binding protein A1Adipose-2.080.012
112GTF2F1general transcription factor IIF, polypeptide 1, 74kDaLiver+2.080.042
113KIF24kinesin family member 24Liver-2.080.045
114CD44CD44 molecule (Indian blood group)Liver+2.080.006
115GGA1golgi-associated, gamma adaptin ear containing, ARF binding protein 1Liver+2.080.014
116OPA3optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)Liver+2.070.031
117NCF4neutrophil cytosolic factor 4, 40kDaLiver+2.070.025
118CRPC-reactive protein, pentraxin-relatedLiver+2.070.037
119TRAM1translocation associated membrane protein 1Liver-2.070.046
120TNPO2transportin 2Liver+2.060.010
121MIAmelanoma inhibitory activityLiver+2.060.025
122ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1Liver-2.060.036
123HLA-Gmajor histocompatibility complex, class I, GLiver+2.050.043
124TPD52L2tumor protein D52-like 2Liver+2.050.039
125ZNF460zinc finger protein 460Liver-2.050.039
126WISP1WNT1 inducible signaling pathway protein 1Liver+2.050.012
127CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunitLiver+2.040.044
128ARF6ADP-ribosylation factor 6Liver+2.040.004
129CD52CD52 moleculeAdipose+2.040.031
130ZNF460zinc finger protein 460Liver+2.030.019
131CXorf56chromosome X open reading frame 56Liver-2.030.046
132HLA-DPB1major histocompatibility complex, class II, DP beta 1Adipose+2.020.005
133COL6A2collagen, type VI, alpha 2Adipose+2.020.004
134NOTCH3notch 3Adipose+2.010.033
135CHAF1Bchromatin assembly factor 1, subunit B (p60)Skeletal Muscle+2.000.033
136AGKacylglycerol kinaseLiver-2.000.011
137CRCT1cysteine-rich C-terminal 1Liver-2.000.030
138DNAJC6DnaJ (Hsp40) homolog, subfamily C, member 6Liver-2.000.032
139COL1A2collagen, type I, alpha 2Adipose+2.000.008
140GYPBglycophorin B (MNS blood group)Blood+2.000.004
141HOXC8homeobox C8Liver+1.990.012
142EPHA3EPH receptor A3Liver-1.990.025
143BCANbrevicanLiver+1.990.019
144HBBhemoglobin, betaLiver+1.990.035
145COX7Bcytochrome c oxidase subunit VIIbBlood+1.980.002
146TMCO3transmembrane and coiled-coil domains 3Liver+1.980.034
147AHSPalpha hemoglobin stabilizing proteinBlood+1.980.012
148TPM2tropomyosin 2 (beta)Adipose+1.980.000
149BTBD2BTB (POZ) domain containing 2Liver+1.980.032
150IL1RNinterleukin 1 receptor antagonistAdipose+1.980.016
151RHOT2ras homolog family member T2Liver+1.970.036
152PKD1polycystic kidney disease 1 (autosomal dominant)Liver+1.960.002
153PALLDpalladin, cytoskeletal associated proteinAdipose+1.960.006
154TBXA2Rthromboxane A2 receptorLiver+1.960.041
155FTLferritin, light polypeptideAdipose-1.950.011
156YIPF6Yip1 domain family, member 6Blood+1.950.001
157SFI1Sfi1 homolog, spindle assembly associated (yeast)Liver+1.940.010
158ZFP30ZFP30 zinc finger proteinLiver-1.940.043
159LIG3ligase III, DNA, ATP-dependentLiver+1.940.017
160DHRS2dehydrogenase/reductase (SDR family) member 2Liver+1.930.023
161ARHGEF17Rho guanine nucleotide exchange factor (GEF) 17Liver+1.930.041
162BBS4Bardet-Biedl syndrome 4Liver-1.930.019
163PLEKHB2pleckstrin homology domain containing, family B (evectins) member 2Liver+1.930.024
164FBXL15F-box and leucine-rich repeat protein 15Liver+1.930.032
165TNFRSF11Btumor necrosis factor receptor superfamily, member 11bAdipose+1.930.025
166MAGOH2mago-nashi homolog 2 (pseudogene)Liver-1.930.024
167DPYSL3dihydropyrimidinase-like 3Adipose+1.920.047
168KLF13Kruppel-like factor 13Liver+1.920.044
169LTC4Sleukotriene C4 synthaseLiver+1.920.044
170NRXN2neurexin 2Liver+1.920.043
171HMOX1heme oxygenase (decycling) 1Adipose+1.920.002
172SLASrc-like-adaptorLiver+1.920.029
173BPGM2,3-bisphosphoglycerate mutaseBlood+1.910.006
174ALDH1A3aldehyde dehydrogenase 1 family, member A3Adipose+1.910.001
175ESRRAestrogen-related receptor alphaLiver+1.910.031
176CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 8Liver-1.910.049
177CAPZA2capping protein (actin filament) muscle Z-line, alpha 2Blood+1.910.024
178FEZ1fasciculation and elongation protein zeta 1 (zygin I)Adipose+1.900.017
179DAPK2death-associated protein kinase 2Liver+1.900.040
180MXD4MAX dimerization protein 4Liver+1.900.039
181TXNthioredoxinLiver-1.900.019
182ZNF783zinc finger family member 783Liver+1.890.021
183C1QBcomplement component 1, q subcomponent, B chainAdipose+1.890.026
184FGF1fibroblast growth factor 1 (acidic)Adipose+1.890.020
185ATG13autophagy related 13Liver+1.890.036
186CAMKK2calcium/calmodulin-dependent protein kinase kinase 2, betaLiver+1.890.044
187NUP210nucleoporin 210kDaLiver+1.880.031
188SESN3sestrin 3Blood+1.880.002
189SYNJ2synaptojanin 2Liver+1.880.027
190PPP1R12Aprotein phosphatase 1, regulatory subunit 12ALiver+1.880.046
191APOBRapolipoprotein B receptorLiver+1.870.009
192STARD3StAR-related lipid transfer (START) domain containing 3Liver+1.870.025
193RUNX1runt-related transcription factor 1Liver+1.860.046
194CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Adipose+1.860.040
195STRNstriatin, calmodulin binding proteinAdipose-1.860.004
196NSFL1CNSFL1 (p97) cofactor (p47)Liver+1.860.030
197CRKv-crk avian sarcoma virus CT10 oncogene homologLiver+1.860.015
198LTBP3latent transforming growth factor beta binding protein 3Liver+1.850.032
199CD53CD53 moleculeAdipose+1.850.027
200ZFPL1zinc finger protein-like 1Liver+1.840.045
201GYPEglycophorin E (MNS blood group)Blood+1.840.011
202SIPA1signal-induced proliferation-associated 1Liver+1.840.049
203ARF6ADP-ribosylation factor 6Liver+1.840.013
204BIRC5baculoviral IAP repeat containing 5Liver-1.840.028
205TNFSF14tumor necrosis factor (ligand) superfamily, member 14Liver+1.830.047
206RASSF2Ras association (RalGDS/AF-6) domain family member 2Adipose+1.830.014
207CALYcalcyon neuron-specific vesicular proteinLiver-1.820.042
208HRASHarvey rat sarcoma viral oncogene homologAdipose+1.810.005
209GNA11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)Liver+1.810.021
210PYGMphosphorylase, glycogen, muscleAdipose-1.810.030
211MID1midline 1 (Opitz/BBB syndrome)Liver-1.810.020
212SCML1sex comb on midleg-like 1 (Drosophila)Liver-1.800.031
213MFAP4microfibrillar-associated protein 4Adipose+1.800.030
214EFNA4ephrin-A4Liver+1.800.028
215LPCAT3lysophosphatidylcholine acyltransferase 3Liver+1.800.015
216MALLmal, T-cell differentiation protein-likeAdipose+1.800.025
217RSL24D1ribosomal L24 domain containing 1Blood+1.790.015
218TIMM44translocase of inner mitochondrial membrane 44 homolog (yeast)Liver+1.790.018
219HEMGNhemogenBlood+1.790.010
220DNASE2deoxyribonuclease II, lysosomalLiver+1.780.041
221GMFBglia maturation factor, betaBlood+1.780.007
222ABCC13ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogeneBlood+1.770.035
223SOX6SRY (sex determining region Y)-box 6Blood+1.770.002
224SNX16sorting nexin 16Blood+1.770.020
225KIAA0141KIAA0141Liver+1.770.005
226PRR14proline rich 14Liver+1.760.044
227ATP5G2ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)Liver+1.760.047
228GAS2growth arrest-specific 2Liver-1.760.016
229JUNjun proto-oncogeneLiver-1.760.013
230DNAJC6DnaJ (Hsp40) homolog, subfamily C, member 6Blood+1.760.007
231UBE2Wubiquitin-conjugating enzyme E2W (putative)Blood+1.760.012
232SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesinBlood-1.760.044
233PROS1protein S (alpha)Blood+1.750.024
234PTPRCprotein tyrosine phosphatase, receptor type, CLiver+1.740.029
235GIPC2GIPC PDZ domain containing family, member 2Liver-1.730.028
236MXRA5matrix-remodelling associated 5Adipose+1.730.049
237ZYXzyxinAdipose+1.730.020
238S100A4S100 calcium binding protein A4Adipose+1.720.007
239CCL3chemokine (C-C motif) ligand 3Adipose+1.720.011
240WISP2WNT1 inducible signaling pathway protein 2Adipose+1.720.036
241TGFB1transforming growth factor, beta 1Liver+1.720.028
242LEPRleptin receptorLiver-1.720.047
243IRS2insulin receptor substrate 2Liver-1.710.038
244KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 1Liver+1.710.040
245PFKPphosphofructokinase, plateletAdipose+1.710.025
246STARD3StAR-related lipid transfer (START) domain containing 3Liver+1.710.038
247TMEM50Btransmembrane protein 50BBlood+1.710.010
248CCDC176coiled-coil domain containing 176Blood+1.700.024
249MTMR1myotubularin related protein 1Liver+1.700.032
250GPNMBglycoprotein (transmembrane) nmbAdipose+1.700.038
251BCL2A1BCL2-related protein A1Blood+1.700.020
252ACTA2actin, alpha 2, smooth muscle, aortaAdipose+1.700.010
253ARGLU1arginine and glutamate rich 1Blood+1.690.029
254SLC14A1solute carrier family 14 (urea transporter), member 1 (Kidd blood group)Blood+1.690.025
255FZD9frizzled class receptor 9Liver-1.680.025
256MICU2mitochondrial calcium uptake 2Liver-1.680.029
257RPS27Lribosomal protein S27-likeBlood+1.680.013
258FGFR1OP2FGFR1 oncogene partner 2Blood+1.670.012
259SRGNserglycinAdipose+1.670.035
260TAGLNtransgelinAdipose+1.660.010
261TTC33tetratricopeptide repeat domain 33Blood+1.660.029
262MED21mediator complex subunit 21Blood+1.660.015
263RPL31ribosomal protein L31Blood+1.650.010
264TSPAN5tetraspanin 5Blood+1.650.032
265LY96lymphocyte antigen 96Blood+1.650.009
266RAB11ARAB11A, member RAS oncogene familyBlood+1.640.037
267COX7Ccytochrome c oxidase subunit VIIcBlood+1.640.017
268CRISP3cysteine-rich secretory protein 3Blood+1.640.035
269SELTselenoprotein TBlood+1.640.036
270PFKLphosphofructokinase, liverLiver+1.630.044
271FMO3flavin containing monooxygenase 3Adipose+1.610.042
272ANXA3annexin A3Blood+1.610.013
273HTR45-hydroxytryptamine (serotonin) receptor 4, G protein-coupledLiver+1.610.023
274RPL34ribosomal protein L34Blood+1.600.026
275ST3GAL6ST3 beta-galactoside alpha-2,3-sialyltransferase 6Adipose-1.590.048
276SUB1SUB1 homolog (S. cerevisiae)Blood+1.590.028
277ZDHHC21zinc finger, DHHC-type containing 21Blood+1.590.042
278ACTR6ARP6 actin-related protein 6 homolog (yeast)Blood+1.580.050
279LAPTM5lysosomal protein transmembrane 5Adipose+1.580.007
280MMP8matrix metallopeptidase 8 (neutrophil collagenase)Blood+1.570.020
281CASD1CAS1 domain containing 1Blood+1.570.034
282LOC643634tropomyosin 1 (alpha) pseudogeneAdipose+1.570.021
283RPL36Aribosomal protein L36aBlood+1.560.029
284COL3A1collagen, type III, alpha 1Adipose+1.560.006
285PRKCIprotein kinase C, iotaBlood+1.560.037
286ACACBacetyl-CoA carboxylase betaAdipose-1.550.010
287NRIP1nuclear receptor interacting protein 1Blood+1.550.048
288DSC2desmocollin 2Blood+1.550.015
289TNMDtenomodulinLiver-1.550.033
290GYPAglycophorin A (MNS blood group)Blood+1.540.039
291VSIG4V-set and immunoglobulin domain containing 4Adipose+1.540.045
292HNMThistamine N-methyltransferaseBlood+1.530.039
293FCHO2FCH domain only 2Blood+1.530.045
294YOD1YOD1 deubiquitinaseBlood+1.530.031
295TMCO1transmembrane and coiled-coil domains 1Blood+1.530.022
296RBX1ring-box 1, E3 ubiquitin protein ligaseBlood+1.520.013
297C1Rcomplement component 1, r subcomponentAdipose+1.520.026
298DMDdystrophinLiver-1.520.047
299SDC4syndecan 4Liver+1.520.047
300RPS7ribosomal protein S7Blood+1.510.045
301TUBB2Atubulin, beta 2A class IIaAdipose+1.500.033
302KAT2BK(lysine) acetyltransferase 2BBlood+1.490.027
303N4BP2NEDD4 binding protein 2Blood+1.480.048
304TMED3transmembrane emp24 protein transport domain containing 3Adipose+1.480.036
305MIB1mindbomb E3 ubiquitin protein ligase 1Blood+1.480.037
306MBNL3muscleblind-like splicing regulator 3Blood+1.460.015
307RPS17ribosomal protein S17Blood+1.460.037
308ZNHIT3zinc finger, HIT-type containing 3Blood+1.450.033
309PGM2phosphoglucomutase 2Blood+1.450.035
310CD44CD44 molecule (Indian blood group)Adipose+1.430.017
311RAB2BRAB2B, member RAS oncogene familyBlood+1.430.045
312CD58CD58 moleculeBlood+1.430.046
313SMAD2SMAD family member 2Blood+1.380.047
314RND3Rho family GTPase 3Adipose+1.380.023


Search GEO for disease gene expression data for Obesity.

Pathways for genes affiliated with Obesity

About this section

Pathways related to Obesity according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.9PYY, SDC3, FFAR4, MC4R, POMC, ADRB3
2
Show member pathways
10.9PPARG, PPARGC1B, SDC3, POMC, MT-CYB, UCP3
3
Show member pathways
10.9PYY, FFAR4, MC4R, POMC, ADRB3, ADRB2
4
Show member pathways
10.8PPARG, POMC, ADRB3, ADRB2, UCP1
510.7AGRP, POMC, MC4R, SDC3
610.7MC4R, POMC, ADRB3, ADRB2
7
Show member pathways
10.7UCP1, UCP3, MT-CYB, PPARG
810.7PPARG, PPARGC1B, UCP3
9
Show member pathways
10.6FFAR4, POMC, GHRL
1010.6ADRB2, PYY
11
Show member pathways
10.6UCP3, UCP1

Compounds for genes affiliated with Obesity

About this section

Compounds related to Obesity according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1glucose4511.7UCP3, ADRB3, ADRB2, MT-CYB, GHRL, UCP1
2lipid4511.5PPARG, UCP1, ENPP1, NR0B2, UCP3, GHRL
3fatty acid4511.5AGRP, UCP1, UCP3, GHRL, ADRB3, PYY
4cholesterol45 30 26 1314.4NR0B2, UCP1, UCP3, GHRL, ADRB3, MC4R
5estrogen4511.4NR0B2, PPARG, ADRB3, PYY, ADRB2, UCP3
6alanine4511.4ADRB3, GHRL, MT-CYB, PPARG, UCP1, MC4R
7norepinephrine45 26 1313.3UCP1, UCP3, GHRL, ADRB2, ADRB3, POMC
82-deoxyglucose45 1312.3PPARG, PYY, POMC, GHRL, UCP3, AGRP
9nitric oxide45 26 1313.3UCP1, MT-CYB, MC4R, ADRB3, GHRL, UCP3
10cocaine45 1312.3ADRB2, POMC, MC4R, AGRP, PYY, GHRL
11atp45 3012.3PYY, UCP1, ADRB3, ENPP1, AGRP, UCP3
12hydrogen45 2612.2ADRB2, MT-CYB, UCP3, UCP1, PYY, GHRL
13cyclic amp45 2612.2ENPP1, PYY, GHRL, UCP1, ADRB2, ADRB3
14amphetamine45 51 1313.2GHRL, AGRP, POMC, MC4R, PYY
15clozapine45 30 51 1314.2GHRL, ADRB2, MC4R, ADRB3, POMC
16acth4511.2AGRP, GHRL, PYY, POMC, MC4R
17dexamethasone45 51 30 1314.2ADRB3, ENPP1, PPARG, POMC, ADRB2, GHRL
18opiate4511.1ADRB2, POMC, MC4R, GHRL
19metformin45 51 1313.1PPARG, GHRL, POMC, ENPP1
20c-peptide4511.1PYY, ADRB3, UCP1, GHRL
21triiodothyronine4511.1GHRL, POMC, UCP3, UCP1
22catecholamine4511.1POMC, ADRB3, ADRB2, UCP1
23palmitate4511.1UCP1, PPARG, MC4R, UCP3
24gtp45 3012.1UCP3, UCP1, MT-CYB, ADRB2, PYY
25rosiglitazone30 45 51 26 1315.1UCP1, GHRL, PPARG, UCP3
26arginine4511.1GHRL, MC4R, PYY, POMC, ADRB3, ADRB2
27alpha msh4511.1MC4R, POMC, AGRP
285-hydroxytryptamine4511.1ADRB2, PYY, POMC, GHRL
29intralipid4511.0PYY, UCP3, GHRL
30oxyntomodulin45 6112.0GHRL, AGRP, PYY
31thyroxine45 2612.0PPARG, GHRL, UCP1, POMC
32orlistat45 61 1313.0PPARG, GHRL, PYY
33thiazolidinedione4511.0PPARG, UCP1, UCP3
34dopamine45 30 26 1314.0PYY, GHRL, ADRB2, POMC, MC4R
35salbutamol45 51 30 26 1315.0UCP3, ADRB2, ADRB3
36carazolol45 3011.9ADRB2, ADRB3
37ici 1185513010.9ADRB2, ADRB3
38sr59230a3010.9ADRB3, ADRB2
39isoprenaline3010.9ADRB3, ADRB2
40bezafibrate45 30 1312.9PPARG, UCP3, UCP1
41[125i]icyp3010.9ADRB3, ADRB2
42cgp 1217730 4511.8ADRB3, ADRB2
43bupranolol30 45 1312.8ADRB2, ADRB3
44nadolol45 30 1312.7ADRB2, ADRB3
45gaba4510.7PYY, GHRL, POMC, ADRB2
46procaterol45 30 1312.7ADRB3, ADRB2
47pgc14510.7PPARG, UCP1
48naloxone45 30 51 1313.7POMC, ADRB2, GHRL
49gnrh4510.6POMC, PYY, ADRB2, GHRL
50oxygen45 2611.5GHRL, UCP3, UCP1, ADRB3, MT-CYB, ADRB2

GO Terms for genes affiliated with Obesity

About this section

Cellular components related to Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:000561510.8AGRP, ENPP1, GHRL, POMC, PYY
2secretory granule lumenGO:003477410.3GHRL, POMC

Biological processes related to Obesity according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1brown fat cell differentiationGO:005087311.0UCP1, ADRB2, ADRB3, PPARG
2response to coldGO:000940911.0PPARG, ADRB3, ADRB2, UCP3
3feeding behaviorGO:000763111.0AGRP, MC4R, PYY, MRAP2
4diet induced thermogenesisGO:000202411.0MC4R, ADRB3, ADRB2
5eating behaviorGO:004275511.0AGRP, ADRB3, PYY
6adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:000718810.9MC4R, ADRB3, ADRB2
7response to insulinGO:003286810.9AGRP, UCP3, MC4R
8heat generationGO:003164910.9ADRB3, ADRB2
9generation of precursor metabolites and energyGO:000609110.9POMC, ADRB3, ENPP1
10desensitization of G-protein coupled receptor protein signaling pathway by arrestinGO:000203210.9ADRB3, ADRB2
11vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:000202510.8ADRB3, ADRB2
12energy reserve metabolic processGO:000611210.8MRAP2, MC4R, ADRB3
13adrenergic receptor signaling pathwayGO:007187510.8ADRB2, ADRB3
14adult feeding behaviorGO:000834310.8AGRP, GHRL
15negative regulation of multicellular organism growthGO:004001510.7ADRB2, ADRB3
16positive regulation of bone resorptionGO:004578010.7MC4R, PPARGC1B
17mitochondrial transportGO:000683910.6UCP3, UCP1
18proton transportGO:001599210.6UCP1, UCP3
19hormone-mediated signaling pathwayGO:000975510.5AGRP, GHRL
20activation of adenylate cyclase activityGO:000719010.3ADRB2, ADRB3

Molecular functions related to Obesity according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1oxidative phosphorylation uncoupler activityGO:001707710.8UCP1, UCP3
2type 1 melanocortin receptor bindingGO:007099610.7POMC, MRAP2
3norepinephrine bindingGO:005138010.7ADRB3, ADRB2
4type 4 melanocortin receptor bindingGO:003178210.7MRAP2, POMC
5G-protein coupled receptor bindingGO:000166410.6GHRL, POMC
6type 3 melanocortin receptor bindingGO:003178110.6MRAP2, POMC
7retinoid X receptor bindingGO:004696510.5NR0B2, PPARG
8neuropeptide hormone activityGO:000518410.3AGRP, PYY

Products for genes affiliated with Obesity

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Obesity

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet