MCID: OBS005
MIFTS: 79

Obesity malady

Summaries for Obesity

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

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MedlinePlus:34 Obesity means having too much body fat. it is different from being overweight, which means weighing too much. the weight may come from muscle, bone, fat, and/or body water. both terms mean that a person's weight is greater than what's considered healthy for his or her height. obesity occurs over time when you eat more calories than you use. the balance between calories-in and calories-out differs for each person. factors that might affect your weight include your genetic makeup, overeating, eating high-fat foods, and not being physically active. being obese increases your risk of diabetes, heart disease, stroke, arthritis, and some cancers. if you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases. for example, that means losing 10 to 20 pounds if you weigh 200 pounds. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Obesity is related to insulin resistance and morbid obesity. An important gene associated with Obesity is ADRB2 (adrenoceptor beta 2, surface), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The drugs benzphetamine and phenylpropanolamine hydrochloride and the compounds lipid and glucose have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Wikipedia:64 Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have... more...

Description from OMIM:47 601665,607514

Aliases & Classifications for Obesity

Sources:
8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 22GTR, 47OMIM, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

obesity 8 43 20 22 47 45 34 61


External Ids:

Disease Ontology8 DOID:9970
ICD9CM27 278.00
MeSH35 D009765
NCIt40 C3283
OMIM47 601665

Related Diseases for Obesity

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Obesity family:

obesity, mc4r-related obesity, susceptibility to, mc3r-related
obesity, early-onset obesity with impaired prohormone processing
obesity, late-onset

Diseases related to Obesity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 657)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.7HSD11B1, PYY, UCP2, UCP1, MC3R, LEP
2morbid obesity31.7LEPR, PYY, GHRL, FTO, MC4R, MC3R
3polycystic ovary syndrome31.3ADRB3, LEPR, LEP, POMC, GHRL, PPARG
4fatty liver disease31.1PPARG, LEP
5glucose intolerance31.0GHRL, PPARG, UCP2, LEP, MC4R, LEPR
6atherosclerosis30.9ENPP1, UCP1, GHRL, PPARG, GHSR, LEP
7prader-willi syndrome30.9GHRL, LEP, PYY, GHSR, LEPR
8acanthosis nigricans30.8LEP
9gestational diabetes30.8LEP, LEPR, ADRB3, ENPP1
10asthma30.8GHRL, POMC, ADRB2
11hyperandrogenism30.7MC4R, LEP, POMC, PPARG
12hypertriglyceridemia30.7LEP, PPARG, ADRB3
13anorexia nervosa30.7MC4R, MC3R, LEP, LEPR, PYY, GHRL
14coronary heart disease30.6LEP, ADRB2, ADRB3, UCP2
15hyperinsulinism30.6GHRL, MC4R, LEP, LEPR, PPARG
16cushing's syndrome30.6LEP, POMC, HSD11B1, GHSR, GHRL
17adenocarcinoma30.6GHRL, UCP2, ADRB2, PYY, HSD11B1
18coronary artery disease,30.4PPARG, GHRL, ENPP1, LEPR, ADRB3, ADRB2
19colorectal cancer30.4PPARG, LEPR, GHRL
20infertility30.4LEPR, LEP
21bulimia nervosa30.4MC4R, GHRL
22type 1 diabetes30.4ADRB2, LEP, ADRB3, ENPP1, LEPR, UCP1
23growth hormone deficiency30.3POMC, GHRL, GHSR, LEP
24arthritis30.3ADRB2, LEP, POMC, GHRL
25thyroiditis30.3POMC
26metabolic syndrome x30.2HSD11B1, PPARG, LEP
27alzheimer's disease30.2ADRB2, PCSK1, PPARG, UCP2, PYY
28hypoglycemia30.2POMC, GHRL, ADRB2
29insulinoma30.1PCSK1, UCP1, UCP2, GHSR, LEPR, GHRL
30diabetic nephropathy30.1PPARG, ENPP1, ADRB3, UCP1
31adenoma30.0POMC, PYY, HSD11B1, PPARG, GHSR, GHRL
32familial partial lipodystrophy29.9LEP, PPARG
33obesity with impaired prohormone processing29.9PCSK1
34acth deficiency29.8MC4R, PCSK1, POMC, HSD11B1
35bronchitis29.8MC4R, GHRL, LEP
36amenorrhea29.8POMC, LEP
37pulmonary disease, chronic obstructive29.8ADRB2
38type 2 diabetes mellitus29.6LEPR, LEP, MC4R, PCSK1, GHRL, PPARG
39acromegaly29.6POMC, LEP, LEPR, GHRL, GHSR, HSD11B1
40pituitary tumors29.6PPARG, GHRL, GHSR, PCSK1, LEPR, POMC
41pheochromocytoma29.5PYY, POMC, PCSK1, UCP1, ADRB2
42adrenal gland hyperfunction29.5LEP, POMC, GHRL
43uremia29.5ENPP1, LEP
44cystic fibrosis29.5ADRB2
45n syndrome10.7
46sleep apnea10.6
47obesity, early-onset10.6
48obesity, variation in10.5
49nonalcoholic steatohepatitis10.5
50leptin deficiency10.4

Graphical network of the top 20 diseases related to Obesity:



Diseases related to obesity

Clinical Features for Obesity

Sources:
47OMIM
See all sources

Clinical features from OMIM:

601665,607514

Drugs & Therapeutics for Obesity

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Obesity

Drug clinical trials:

Search ClinicalTrials for Obesity

Search NIH Clinical Center for Obesity

Highlights from CenterWatch's Drugs in Clinical Trials Database for Obesity:

idCompanyCompoundMechanismPhase
1Ablaris TherapeuticsAdipotideA Prohibitin-Targeting Peptide 1I
2Zafgenbeloranib hemioxalatea MetAP2 inhibitor IIa
3Rhythm PharmaceuticalsRM-493a small-peptide MC4R agonistII
4High Point PharmaceuticalsHPP404A selective H3 receptor antagonistII
5Novo Nordiskliraglutidea GLP-1 derivativeIII

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Obesity

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Obesity:

id Genetic test Affiliating Genes
1 Obesity20 22

Anatomical Context for Obesity

Animal Models for Obesity or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Obesity

Sources:
51PubMed
See all sources

Articles related to Obesity:

(show top 50)    (show all 5828)
idTitleAuthorsYear
1
Averting Obesity and Type 2 Diabetes in India through Sugar-Sweetened Beverage Taxation: An Economic-Epidemiologic Modeling Study. (24409102)
2014
2
Circulating Triacylglycerol Signatures in Nonalcoholic Fatty Liver Disease Associated With the I148M Variant in PNPLA3 and With Obesity. (24009255)
2014
3
The influence of high versus low sodium intake on blood pressure and haemodynamics in patients with morbid obesity. (23868085)
2013
4
Obesity is a risk factor for thyroid cancer in a large, ultrasonographically screened population. (23513231)
2013
5
Obesity, Hypertension and Hypercholesterolemia as Risk Factors for Atherosclerosis Leading to Ischemic Events. (24372218)
2013
6
Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity. (23928404)
2013
7
Exercise and obesity in fibromyalgia: beneficial roles of IGF-1 and resistin? (23446104)
2013
8
Intensive lifestyle intervention fails to improve patient-oriented outcomes in persons with obesity and diabetes. (24364556)
2013
9
Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity. (24325907)
2013
10
Insulin action in morbid obesity: a focus on muscle and adipose tissue. (23933689)
2013
11
Impact of hypoalphalipoproteinemia on quality of life in Taiwanese women with central obesity. (24322908)
2013
12
Macrocephaly, obesity, mental (intellectual) disability, and ocular abnormalities: alternative definition and further delineation of MOMO syndrome. (22821547)
2012
13
Association of the FTO rs9939609 polymorphism with obesity in Roma/Gypsy population. (21989907)
2012
14
Morbid obesity increases cost and complication rates in spinal arthrodesis. (22037526)
2012
15
BClI polymorphism of the glucocorticoid receptor gene is associated with increased obesity, impaired glucose metabolism and dyslipidaemia in patients with Addison's disease. (22587831)
2012
16
Structural and inflammatory heterogeneity in subcutaneous adipose tissue: relation with liver histopathology in morbid obesity. (22245892)
2012
17
ADRB2 G-G haplotype associated with breast cancer risk among Hispanic and non-Hispanic white women: interaction with type 2 diabetes and obesity. (22864926)
2012
18
Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity. (21386805)
2012
19
Retrograde intussusception 5 years after Roux-en-Y gastric bypass for morbid obesity. (20844982)
2012
20
The link between obesity and psoriatic arthritis. (22798633)
2012
21
Liver and muscle in morbid obesity: the interplay of fatty liver and insulin resistance. (22359625)
2012
22
Transoral surgery for morbid obesity. (22110835)
2011
23
Does morbid obesity affect the outcome of total hip replacement?: an analysis of 3290 THRs. (21357952)
2011
24
Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. (21248185)
2011
25
The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site. (21533135)
2011
26
Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes. (21674055)
2011
27
Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. (20089859)
2010
28
Association between anthropometric measures of obesity, metabolic disturbances and polymorphism G-308A of the tumor necrosis factor-alpha gene in children. (21147642)
2010
29
Obesity, food selectivity, and physical activity in individuals with fragile X syndrome. (20946001)
2010
30
Anti-melanocortin-4 receptor autoantibodies in obesity. (19050052)
2009
31
Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitus. (19837931)
2009
32
Association of CHRNA2 polymorphisms with overweight/obesity and clinical characteristics in a Korean population. (18588430)
2008
33
Reply to the letter to the editor "Long-term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer". (18395892)
2008
34
The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. (17996046)
2007
35
Obesity is associated with altered metabolic and reproductive activity in the mare: effects of metformin on insulin sensitivity and reproductive cyclicity. (16930507)
2006
36
Retinol-binding protein 4 in human obesity. (17003346)
2006
37
The heart in obesity-hypertension. (16076275)
2005
38
Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation. (12687350)
2003
39
The association between leptin and proinsulin is lost with central obesity. (12190889)
2002
40
Proinsulin in girls: relationship to obesity, hyperinsulinemia, and puberty. (12364457)
2002
41
Synergy of sibutramine and low-dose leptin in treatment of diet-induced obesity in rats. (11474475)
2001
42
Urinary epinephrine and norepinephrine interrelations with obesity, insulin, and the metabolic syndrome in Hong Kong Chinese. (11229419)
2001
43
Human obesity and point mutations of leptin and leptin receptor]. (11268611)
2001
44
GH/IGF-I axis in Prader-Willi syndrome: evaluation of IGF-I levels and of the somatotroph responsiveness to various provocative stimuli. Genetic Obesity Study Group of Italian Society of Pediatric Endocrinology and Diabetology. (10800760)
2000
45
Recent progress in obesity pharmacotherapy. (17024036)
2000
46
Tumor necrosis factor-alpha; a possible pathogenic factor in obesity in insulin resistant and non-insulin-dependent diabetes mellitus?]. (9685802)
1998
47
Mechanisms of the kinetic defect in insulin action in obesity and NIDDM. (9166671)
1997
48
1995 EASD meetings. Immunology, insulin, amylin, obesity, retinopathy, and neuropathy. (8732728)
1996
49
Growth hormone secretion after testosterone administration to men with visceral obesity. (16353427)
1994
50
Acanthosis nigricans--decreased extracellular matrix viscosity: cancer, obesity, diabetes, corticosteroids, somatotrophin. (8502193)
1993

Genetic Variations for Obesity

Expression for genes affiliated with Obesity

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Obesity

Search GEO for disease gene expression data for Obesity.

Pathways for genes affiliated with Obesity

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Obesity according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
13.1ADRB3, MC4R, POMC, MC3R, FFAR4, GHRL
2
Hide members
12.7GHSR, PYY, GHRL, FFAR4, POMC, ADRB2
3
Hide members
11.6UCP1, UCP2, LEP, LEPR, PPARG
4
Hide members
11.4UCP1, PPARG, ADRB3, ADRB2
5
Hide members
11.4ADRB2, PYY, ADRB3, ADRA2B
6
Hide members
11.1ADRB3, ADRA2B, ADRB2
7
Hide members
11.1PCSK1, POMC, GHRL
8
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
11.1LEPR, LEP, POMC
911.1LEPR, LEP, POMC
10
Hide members
10.9GHRL, PCSK1
11
Hide members
10.9UCP1, UCP2
12
Hide members
10.9PCSK1, POMC
1310.9POMC, MC4R

Compounds for genes affiliated with Obesity

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Obesity according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1lipid4514.3GHRL, UCP2, MC3R, MC4R, PCSK1, PYY
2glucose4513.4PYY, UCP2, PPARG, GHRL, PCSK1, MC3R
3cholesterol45 29 11 2416.4PYY, HSD11B1, UCP2, PPARG, GHRL, LEP
4dexamethasone45 50 29 1116.1LEP, ENPP1, GHRL, GHSR, PPARG, HSD11B1
5arginine4513.1POMC, PCSK1, LEPR, ADRB3, ADRB2, LEP
6alanine4513.1PPARG, GHRL, POMC, MC4R, LEPR, ADRB3
7acth4512.9POMC, GHRL, GHSR, PYY, HSD11B1, MC4R
8testosterone45 60 11 2415.9HSD11B1, PPARG, UCP1, GHRL, POMC, LEP
9fatty acid4512.7LEPR, ENPP1, MC4R, GHRL, PPARG, UCP1
10cocaine45 1113.7POMC, LEPR, LEP, MC3R, MC4R, GHRL
11ribonucleic acid4512.7HSD11B1, LEPR, PCSK1, POMC, GHSR, UCP1
12nitric oxide45 11 2414.5UCP2, GHRL, MC4R, LEPR, ADRB3, ADRB2
13serine4512.5PCSK1, LEP, LEPR, ADRB2, POMC, GHRL
14triiodothyronine4512.5LEPR, LEP, POMC, GHRL, UCP1, UCP2
15corticosterone45 60 2414.5MC3R, LEPR, HSD11B1, LEP, MC4R, POMC
16dopamine45 29 11 2415.4GHRL, ADRB2, LEPR, MC3R, MC4R, GHSR
17thyroxine45 2413.4LEP, GHRL, UCP2, POMC, LEPR, UCP1
18estradiol45 11 2414.4LEPR, LEP, GHSR, POMC, HSD11B1, GHRL
19glutamine4512.4ADRB2, ENPP1, HSD11B1, UCP2, PPARG, POMC
20adenylate4512.3GHRL, POMC, PCSK1, GHSR, MC4R, ADRB3
21cyclic amp45 2413.3GHRL, ENPP1, ADRB2, UCP1, PYY, ADRB3
22norepinephrine45 11 2414.2ADRA2B, ADRB3, PYY, UCP2, UCP1, POMC
23gnrh4512.2GHRL, PCSK1, MC3R, PYY, LEPR, ADRB2
24c-peptide4512.2LEP, ADRB3, PCSK1, GHRL, UCP1, PYY
25clozapine45 29 50 1115.2ADRB2, ADRA2B, ADRB3, LEP, POMC, GHRL
26rosiglitazone45 50 29 11 2416.2GHRL, LEP, PPARG, UCP1, UCP2, HSD11B1
27progesterone45 60 29 11 2416.2PCSK1, LEPR, ADRB2, LEP, HSD11B1, UCP1
28epinephrine45 11 2414.1GHRL, POMC, LEP, ADRB3, ADRA2B, ADRB2
29olanzapine50 45 29 11 2416.0GHRL, ADRA2B, ADRB3, LEPR, LEP
30metformin45 50 1114.0PPARG, GHRL, POMC, LEP, ENPP1
31catecholamine4511.9UCP2, UCP1, POMC, ADRB3, ADRB2
32shu 911945 6012.8MC3R, MC4R, LEP, POMC
33alpha msh4511.7LEP, MC3R, MC4R, POMC
34oxyntomodulin45 6012.7LEP, PCSK1, PYY, GHRL
35forskolin45 50 1113.7GHSR, ADRB2, POMC, HSD11B1
36orlistat45 60 1113.7LEP, PPARG, GHRL, PYY
37thiazolidinedione4511.6LEP, PPARG, UCP2, UCP1
38glycerol45 11 2413.6ADRB2, LEP, HSD11B1, PPARG, POMC
39estrogen4511.6HSD11B1, PCSK1, ADRB3
40naloxone45 50 29 1114.6ADRB2, LEP, POMC, GHRL
41amphetamine45 1112.5MC4R, POMC, GHRL, PYY
42[d-trp8]-gamma-msh6011.5POMC, MC4R, MC3R
43alpha-msh6011.5POMC, MC4R, MC3R
44pg 1066011.5POMC, MC3R, MC4R
45hs 0146011.4MC3R, POMC, MC4R
46clonidine45 29 1113.4ADRA2B, PYY, POMC, LEP
47clenbuterol45 1112.3ADRB2, ADRB3, LEP
48Droxidopa1111.1ADRB3, ADRA2B, ADRB2
492-deoxyglucose45 1112.1PPARG, GHRL, POMC, PYY
50Ephedra1111.0ADRA2B, ADRB2, ADRB3

GO Terms for genes affiliated with Obesity

Sources:
16Gene Ontology
See all sources

Cellular components related to Obesity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.8ENPP1, LEP, PCSK1, POMC, GHRL, PYY
2secretory granule lumenGO:03477410.8PCSK1, POMC, GHRL

Biological processes related to Obesity according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1brown fat cell differentiationGO:05087311.7ADRB2, ADRB3, PPARG, UCP1
2adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718811.7ADRB2, ADRB3, MC3R, MC4R
3cellular response to insulin stimulusGO:03286911.7UCP2, PPARG, GHSR, ENPP1
4regulation of blood pressureGO:00821711.7PPARG, POMC, MC3R, LEP
5energy reserve metabolic processGO:00611211.7MC4R, LEP, LEPR, ADRB3
6cell-cell signalingGO:00726711.5ADRA2B, PCSK1, POMC, PYY
7diet induced thermogenesisGO:00202411.5MC4R, ADRB3, ADRB2
8adult feeding behaviorGO:00834311.5LEP, GHRL, GHSR
9eating behaviorGO:04275511.5ADRB3, LEP, PYY
10response to coldGO:00940911.5ADRB2, ADRB3, PPARG
11generation of precursor metabolites and energyGO:00609111.4ADRB3, ENPP1, POMC
12negative regulation of inflammatory responseGO:05072811.4GHSR, GHRL, FFAR4
13positive regulation of MAPK cascadeGO:04341011.4ADRB2, ADRB3, LEP
14G-protein coupled receptor signaling pathwayGO:00718611.3ADRA2B, GHRL, GHSR, PYY
15positive regulation of appetiteGO:03210011.2GHSR, GHRL
16heat generationGO:03164911.2ADRB3, ADRB2
17desensitization of G-protein coupled receptor protein signaling pathway by arrestinGO:00203211.2ADRB3, ADRB2
18vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:00202511.2ADRB3, ADRB2
19negative regulation of tumor necrosis factor biosynthetic processGO:04253611.2GHSR, GHRL
20negative regulation of interleukin-6 biosynthetic processGO:04540911.2GHRL, GHSR
21negative regulation of interleukin-1 beta productionGO:03269111.1GHRL, GHSR
22growth hormone secretionGO:03025211.1GHSR, GHRL
23actin polymerization or depolymerizationGO:00815411.0GHSR, GHRL
24negative regulation of multicellular organism growthGO:04001511.0ADRB2, ADRB3
25mitochondrial transportGO:00683910.9UCP2, UCP1
26decidualizationGO:04669710.9GHRL, GHSR
27peptide hormone processingGO:01648610.6PCSK1, POMC

Molecular functions related to Obesity according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1peptide hormone bindingGO:01704611.3MC3R, MC4R, GHSR
2hormone activityGO:00517911.1LEP, POMC, PYY
3melanocyte-stimulating hormone receptor activityGO:00498011.0MC3R, MC4R
4norepinephrine bindingGO:05138011.0ADRB2, ADRB3
5epinephrine bindingGO:05137910.9ADRB3, ADRA2B
6melanocortin receptor activityGO:00497710.8MC4R, MC3R
7neuropeptide bindingGO:04292310.6MC3R, MC4R

Products for genes affiliated with Obesity

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Obesity

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet