MCID: OBS005
MIFTS: 94

Obesity malady

Genetic diseases, Rare diseases, Metabolic diseases categories

Aliases & Classifications for Obesity

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Obesity, Aliases & Descriptions:

Name: Obesity 45 30 9 41 20 43 22 32 60
Body Mass Index Quantitative Trait Locus 10 45 60
Obesity, Severe, and Type Ii Diabetes 45 30
Obesity, Autosomal Dominant 45 10
Obesity, Mild, Early-Onset 45
 
Obesity, Association with 45
Obesity, Variation in 45
Obesity, Early-Onset 45
Obesity, Late-Onset 45
Obesity, Severe 45


Classifications:



External Ids:

Disease Ontology9 DOID:9970
ICD9CM27 278.00
NCIt38 C3283
MeSH33 D009765
ICD1025 E66

Summaries for Obesity

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MedlinePlus:32 Obesity means having too much body fat. it is different from being overweight, which means weighing too much. the weight may come from muscle, bone, fat, and/or body water. both terms mean that a person's weight is greater than what's considered healthy for his or her height. obesity occurs over time when you eat more calories than you use. the balance between calories-in and calories-out differs for each person. factors that might affect your weight include your genetic makeup, overeating, eating high-fat foods, and not being physically active. being obese increases your risk of diabetes, heart disease, stroke, arthritis, and some cancers. if you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases. for example, that means losing 10 to 20 pounds if you weigh 200 pounds. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Obesity, also known as body mass index quantitative trait locus 10, is related to morbid obesity and polycystic ovary syndrome, and has symptoms including obesityand abnormality of metabolism/homeostasis. An important gene associated with Obesity is PPARG (peroxisome proliferator-activated receptor gamma), and among its related pathways are Signaling by GPCR and Metabolism. The drugs benzphetamine and phenylpropanolamine hydrochloride and the compounds glucose and lipid have been mentioned in the context of this disorder. Affiliated tissues include liver, ovary and skeletal muscle, and related mouse phenotypes are homeostasis/metabolism and adipose tissue.

Wikipedia:63 Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a... more...

Descriptions from OMIM:45 601665,607514

Related Diseases for Obesity

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Diseases in the Obesity family:

Obesity, Mc4r-Related Obesity, Pparg-Related
Obesity, Susceptibility to, Cartpt-Related Obesity, Susceptibility to, Mc3r-Related
Obesity, Ucp3-Related Obesity, Pyy-Related
Obesity, Sim1-Related

Diseases related to Obesity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 725)
idRelated DiseaseScoreTop Affiliating Genes
1morbid obesity32.8GHRL, ADRB3, MC4R, PYY
2polycystic ovary syndrome32.4GHRL, ADRB3, POMC, PPARG
3eating disorder32.1AGRP, GHRL, MC4R, PYY
4atherosclerosis32.1PPARG, ADRB3, ADRB2, GHRL, UCP3, UCP1
5prader-willi syndrome32.0PYY, GHRL, AGRP
6hyperandrogenism31.9POMC, MC4R, PPARG
7anorexia nervosa31.9PYY, MC4R, POMC, GHRL, AGRP
8glucose intolerance31.8GHRL, PYY
9hyperglycemia31.8ENPP1, GHRL, ADRB3, POMC, PYY, PPARG
10hyperinsulinism31.7GHRL, MC4R, PPARG
11metabolic syndrome x31.6PPARG, POMC, ADRB3, ADRB2, GHRL, UCP3
12coronary artery disease31.5PPARG, ADRB3, ADRB2, GHRL, ENPP1
13hypothyroidism31.5AGRP, GHRL, POMC
14bulimia nervosa31.4MC4R, GHRL
15hypoglycemia31.2GHRL, ADRB2, POMC
16growth hormone deficiency31.2POMC, GHRL
17adenoma31.0PPARG, PYY, POMC, GHRL
18lipid metabolism disorder30.9ADRB2, ADRB3, PPARG
19hypopituitarism30.8POMC, GHRL
20diabetes mellitus, noninsulin-dependent30.8PPARG, PYY, MC4R, ADRB3, ADRB2, GHRL
21pheochromocytoma30.6UCP1, ADRB2, POMC, PYY
22diabetes mellitus, insulin-dependent30.6ADRB3, ADRB2, UCP1, ENPP1
23pituitary tumors30.6GHRL, POMC, PPARG
24pituitary adenoma30.5PPARG, POMC, GHRL
25acth deficiency30.5POMC, MC4R
26adrenal gland hyperfunction30.5GHRL, POMC
27liver disease10.8
28hepatitis10.8
29fatty liver disease10.8
30hypertension, essential10.7ADRB2, ADRB3, POMC, PPARG
31familial hyperlipidemia10.7PPARG, ADRB3, UCP3, UCP1
32microvascular complications of diabetes 310.7ENPP1, UCP1, ADRB3, PPARG
33non-suppurative otitis media10.7AGRP, GHRL, MC4R
34sleep apnea10.6
35nelson syndrome10.6PPARG, POMC
36endotheliitis10.6
37congenital heart disease10.6ADRB2, POMC, PPARG
38carcinoid syndrome10.6PYY, POMC, GHRL
39cholera10.6PYY, POMC, ADRB2
40acanthosis nigricans10.6
41obstructive sleep apnea10.6
42breast cancer10.6
43pancreatitis10.6
44gastrointestinal system disease10.6GHRL, PYY
45asthma10.5
46hypertriglyceridemia10.5
47thyroiditis10.5
48nonalcoholic steatohepatitis10.5
49neuroendocrine tumor10.5POMC
50craniopharyngioma10.5

Graphical network of the top 20 diseases related to Obesity:



Diseases related to obesity

Symptoms for Obesity

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Symptoms by clinical synopsis from OMIM:

601665

Clinical features from OMIM:

601665,607514

HPO human phenotypes related to Obesity:

id Description Frequency HPO Source Accession
1 obesity HP:0001513
2 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Obesity

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Genetic Tests for Obesity

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Genetic tests related to Obesity:

id Genetic test Affiliating Genes
1 Obesity20 22

Anatomical Context for Obesity

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MalaCards organs/tissues related to Obesity:

31
Liver, Ovary, Skeletal muscle, Heart, Adipocyte, Bone, Kidney, Breast, Endothelial, Testes, Thyroid, Brain, Pituitary, Prostate, Monocytes, T cells, Colon, Skin, Lung, Neutrophil, Hypothalamus, B cells, Smooth muscle, Pancreatic islet, Pancreas, Spinal cord, Myeloid, Salivary gland, Bone marrow, Lymph node, Small intestine, Placenta, Testis, Amygdala, Whole blood, Spleen, Thymus, Cortex, Cerebellum, Retina, Nk cells, Pons, Tongue, Adrenal cortex

Animal Models for Obesity or affiliated genes

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Publications for Obesity

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Articles related to Obesity:

(show top 50)    (show all 9089)
idTitleAuthorsYear
1
Perceived weight in youths and risk of overweight or obesity six years later. (24360137)
2014
2
MicroRNA Functions in Brite/Brown Fat - Novel Perspectives towards Anti-Obesity Strategies. (25408843)
2014
3
Body Mass Index Categories and Mortality Risk in US Adults: The Effect of Overweight and Obesity on Advancing Death. (24432921)
2014
4
Substantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder. (23639407)
2013
5
Family Structure and Childhood Obesity: An Analysis Through 8th Grade. (24370680)
2013
6
Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children. (23510779)
2013
7
Influence of attention-deficit/hyperactivity disorder on binge eating behaviors and psychiatric comorbidity profile of obese women. (24246603)
2013
8
Surgically induced interpregnancy weight loss and prevalence of overweight and obesity in offspring. (24349234)
2013
9
Cystic fibrosis: from protein-energy malnutrition to obesity with dyslipidemia. (24800027)
2013
10
Uncoupling protein-2 45-base pair insertion/deletion polymorphism: is there an association with severe obesity and weight loss in morbidly obese subjects? (22568573)
2012
11
Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China. (21892197)
2011
12
GPR43: an emerging target for the potential treatment of type 2 diabetes, obesity and insulin resistance. (20336586)
2010
13
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
14
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch. (20492663)
2010
15
Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes. (19558533)
2010
16
Hypothalamic obesity complicated by adipsic central diabetes insipidus following surgical resection of a craniopharyngioma. (19817945)
2009
17
Obesity and polycystic ovary syndrome. (20054201)
2009
18
Evaluation of bone disease in morbidly obese women after gastric bypass and risk factors implicated in bone loss. (19412643)
2009
19
Obesity alters cytokine gene expression and promotes liver injury in rats with acute pancreatitis. (18223607)
2008
20
The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. (18295974)
2008
21
Metabolic effects of weight loss on a very-low-carbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects. (18174038)
2008
22
Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) study. (18452784)
2008
23
The preservation of insulin sensitivity in obese women without diabetes. (18672628)
2008
24
Double-blind, randomized trial comparing efficacy and safety of continuing olanzapine versus switching to quetiapine in overweight or obese patients with schizophrenia or schizoaffective disorder. (19209252)
2008
25
Novel melanocortin 4 receptor gene mutations in severely obese children. (17941900)
2008
26
Fibrinogen, plasma viscosity and blood viscosity in obesity. Relationship with insulin resistance. (17942983)
2007
27
Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in utah. (16741266)
2006
28
Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. (17065359)
2006
29
Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome. (16077717)
2005
30
Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. (15975705)
2005
31
Superior mesenteric artery syndrome after laparoscopic Roux-en-Y gastric bypass for morbid obesity. (15329194)
2004
32
Addition of rosiglitazone to metformin is most effective in obese, insulin-resistant patients with type 2 diabetes. (12681023)
2003
33
Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses. (12960083)
2003
34
Weight loss in a patient with morbid obesity under treatment with oleoyl-estrone]. (14588193)
2003
35
Central and peripheral glucocorticoid receptor function in abdominal obesity. (11936464)
2002
36
Resistin, obesity and insulin resistance--the emerging role of the adipocyte as an endocrine organ. (11794158)
2001
37
Overweight/obesity, smoking, and heavy alcohol consumption are important determinants of plasma PAI-1 levels in healthy men. (11465242)
2001
38
Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women. (11157312)
2001
39
A cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats. (10958832)
2000
40
Effect of opioid blockade on insulin and growth hormone (GH) secretion in patients with polycystic ovary syndrome: the heterogeneity of impaired GH secretion is related to both obesity and hyperinsulinism. (9935127)
1999
41
The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk. (9569171)
1998
42
A case of acanthosis nigricans in obese siblings with a pedigree of familial polyposis coli. (9330076)
1997
43
The beta(3)-adrenergic receptor TRP64ARG polymorphism and obesity in Alaskan Eskimos. (9426386)
1997
44
Determinants of the kinetics of very low-density lipoprotein apolipoprotein B-100 in non-obese men. (9269527)
1997
45
Pseudotumor cerebri in a patient with Bartter's syndrome and obesity. (8903869)
1996
46
Lipoprotein lipase gene polymorphisms: associations with hypertriglyceridemia and body mass index in obese people. (7627251)
1995
47
Hormones and obesity. (7980347)
1994
48
Arginine potentiates but does not restore the blunted growth hormone response to growth hormone-releasing hormone in obesity. (1588839)
1992
49
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. (1955512)
1991
50
Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats. (1939742)
1991

Variations for Obesity

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UniProtKB/Swiss-Prot genetic disease variations for Obesity:

62 (show all 30)
id Symbol AA change Variation ID SNP ID
1MC4Rp.Ser30ArgVAR_010704
2MC4Rp.Asp37ValVAR_010705rs13447325
3MC4Rp.Pro78LeuVAR_010706rs13447326
4MC4Rp.Arg165TrpVAR_010709rs13447332
5MC4Rp.Gly252SerVAR_010711rs13447336
6MC4Rp.Ile317ThrVAR_010712rs13447337
7MC4Rp.Asn274SerVAR_015357
8MC4Rp.Thr11AlaVAR_038632
9MC4Rp.Ser36TyrVAR_038633
10MC4Rp.Val50MetVAR_038634
11MC4Rp.Ser58CysVAR_038635
12MC4Rp.Asn62SerVAR_038636
13MC4Rp.Asn97AspVAR_038638
14MC4Rp.Ile102SerVAR_038639
15MC4Rp.Ile102ThrVAR_038640
16MC4Rp.Leu106ProVAR_038641
17MC4Rp.Ile125LysVAR_038642
18MC4Rp.Ser127LeuVAR_038643rs13447331
19MC4Rp.Arg165GlnVAR_038644rs13447332
20MC4Rp.Ile170ValVAR_038645rs121913560
21MC4Rp.Ala175ThrVAR_038646
22MC4Rp.Gly181AspVAR_038647rs13447333
23MC4Rp.Ala219ValVAR_038648
24MC4Rp.Val253IleVAR_038650rs187152753
25MC4Rp.Cys271ArgVAR_038651
26MC4Rp.Cys271TyrVAR_038652
27MC4Rp.Ile316SerVAR_038653
28MC4Rp.Leu325PheVAR_038654
29PPARGp.Pro113GlnVAR_010724rs1800571
30UCP3p.Val102IleVAR_004408rs2229707

Clinvar genetic disease variations for Obesity:

6 (show all 40)
id Gene Variation Type Significance SNP ID Assembly Location
1ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
2ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
3ENPP1NM_006208.2(ENPP1): c.*1043A> Gsingle nucleotide variantrisk factorrs7754561GRCh37Chr 6, 132212694: 132212694
4MC4RMC4R, 4-BP DEL, NT631deletionPathogenic
5MC4RMC4R, 4-BP INS, NT732insertionPathogenic
6MC4RNM_005912.2(MC4R): c.105C> A (p.Tyr35Ter)single nucleotide variantPathogenicrs13447324GRCh37Chr 18, 58039478: 58039478
7MC4RNM_005912.2(MC4R): c.110A> T (p.Asp37Val)single nucleotide variantPathogenicrs13447325GRCh37Chr 18, 58039473: 58039473
8MC4RNM_005912.2(MC4R): c.148G> A (p.Val50Met)single nucleotide variantPathogenicrs121913557GRCh37Chr 18, 58039435: 58039435
9MC4RNM_005912.2(MC4R): c.172A> T (p.Ser58Cys)single nucleotide variantPathogenicrs121913558GRCh37Chr 18, 58039411: 58039411
10MC4RNM_005912.2(MC4R): c.305T> G (p.Ile102Ser)single nucleotide variantPathogenicrs121913559GRCh37Chr 18, 58039278: 58039278
11MC4RNM_005912.2(MC4R): c.508A> G (p.Ile170Val)single nucleotide variantPathogenicrs121913560GRCh37Chr 18, 58039075: 58039075
12MC4RNM_005912.2(MC4R): c.821A> G (p.Asn274Ser)single nucleotide variantPathogenicrs121913561GRCh37Chr 18, 58038762: 58038762
13MC4RMC4R, 1-BP INS, 112AinsertionPathogenic
14MC4RMC4R, 4-BP DEL, 211CTCTdeletionPathogenic
15MC4RMC4R, 2-BP INS, 279GTinsertionPathogenic
16MC4RMC4R, ILE125LYSundetermined variantPathogenic
17MC4RNM_005912.2(MC4R): c.812G> A (p.Cys271Tyr)single nucleotide variantPathogenicrs121913562GRCh37Chr 18, 58038771: 58038771
18MC4RNM_005912.2(MC4R): c.523G> A (p.Ala175Thr)single nucleotide variantPathogenicrs121913563GRCh37Chr 18, 58039060: 58039060
19MC4RNM_005912.2(MC4R): c.947T> G (p.Ile316Ser)single nucleotide variantPathogenicrs121913564GRCh37Chr 18, 58038636: 58038636
20MC4RNM_005912.2(MC4R): c.861T> A (p.Tyr287Ter)single nucleotide variantPathogenicrs121917829GRCh37Chr 18, 58038722: 58038722
21MC4RNM_005912.2(MC4R): c.289A> G (p.Asn97Asp)single nucleotide variantPathogenicrs121913565GRCh37Chr 18, 58039294: 58039294
22MC4RNM_005912.2(MC4R): c.185A> G (p.Asn62Ser)single nucleotide variantPathogenicrs121913566GRCh37Chr 18, 58039398: 58039398
23MC4RMC4R, 15-BP DELdeletionPathogenic
24MC4RNM_005912.2(MC4R): c.380C> T (p.Ser127Leu)single nucleotide variantPathogenicrs13447331GRCh37Chr 18, 58039203: 58039203
25MC4RMC4R, 2-BP DEL, 750GAdeletionPathogenic
26MC4RNM_005912.2(MC4R): c.656C> T (p.Ala219Val)single nucleotide variantPathogenicrs121913567GRCh37Chr 18, 58038927: 58038927
27ADRB3NM_000025.2(ADRB3): c.190T> C (p.Trp64Arg)single nucleotide variantrisk factorrs4994GRCh37Chr 8, 37823798: 37823798
28ADRB2NM_000024.5(ADRB2): c.79C> G (p.Gln27Glu)single nucleotide variantrisk factorrs1042714GRCh37Chr 5, 148206473: 148206473
29FFAR4NM_181745.3(FFAR4): c.809G> A (p.Arg270His)single nucleotide variantrisk factorrs116454156GRCh37Chr 10, 95347041: 95347041
30LEPRNM_002303.5(LEPR): c.2880C> G (p.Asn960Lys)single nucleotide variantLikely pathogenicrs193922650GRCh37Chr 1, 66102080: 66102080
31MC4RNM_005912.2(MC4R): c.538T> C (p.Ser180Pro)single nucleotide variantLikely pathogenicrs193922685GRCh37Chr 18, 58039045: 58039045
32MC4RNM_005912.2(MC4R): c.806T> A (p.Ile269Asn)single nucleotide variantLikely pathogenicrs79783591GRCh37Chr 18, 58038777: 58038777
33MC4RNM_005912.2(MC4R): c.835_836dupTG (p.Phe280Alafs)duplicationPathogenicrs193922687GRCh37Chr 18, 58038746: 58038747
34MC4RNM_005912.2(MC4R): c.896C> A (p.Pro299His)single nucleotide variantPathogenicrs52804924GRCh37Chr 18, 58038687: 58038687
35NM_001134944.1(GHRL): c.116G> A (p.Arg39Gln)single nucleotide variantrisk factorrs34911341GRCh37Chr 3, 10331519: 10331519
36NM_001134944.1(GHRL): c.233A> T (p.Gln78Leu)single nucleotide variantrisk factorrs4684677GRCh37Chr 3, 10328453: 10328453
37MRAP2NM_138409.2(MRAP2): c.70G> T (p.Glu24Ter)single nucleotide variantrisk factorGRCh37Chr 6, 84765107: 84765107
38CARTPTNM_004291.3(CARTPT): c.183G> C (p.Leu61Phe)single nucleotide variantrisk factorrs121909065GRCh37Chr 5, 71015730: 71015730
39PYYNM_004160.4(PYY): c.185A> C (p.Gln62Pro)single nucleotide variantrisk factorrs267606994GRCh37Chr 17, 42030667: 42030667
40MT-CYBm.15497G> Asingle nucleotide variantrisk factorrs199951903GRCh37Chr MT, 15497: 15497

Expression for genes affiliated with Obesity

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LifeMap Discovery
Genes differentially expressed in tissues of Obesity patients vs. healthy controls: 30 (show all 11)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1SLNsarcolipinSkeletal Muscle-4.170.031
2GAPDHglyceraldehyde-3-phosphate dehydrogenaseSkeletal Muscle-4.140.045
3MYOTmyotilinLiver-3.660.000
4AZGP1alpha-2-glycoprotein 1, zinc-bindingAdipose-3.650.000
5RPL41ribosomal protein L41Skeletal Muscle-3.560.040
6IL17RCinterleukin 17 receptor CLiver+3.520.002
7CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 9Liver-3.460.001
8GREB1growth regulation by estrogen in breast cancer 1Liver-3.300.009
9IGHMimmunoglobulin heavy constant muLiver+3.290.003
10ZFP36L2ZFP36 ring finger protein-like 2Liver+3.090.019
11TTNtitinSkeletal Muscle-3.030.043

Search GEO for disease gene expression data for Obesity.

Pathways for genes affiliated with Obesity

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Pathways related to Obesity according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.9FFAR4, MC4R, SDC3, ADRB3, ADRB2, GHRL
2
Show member pathways
10.9PPARG, PPARGC1B, SDC3, POMC, MT-CYB, UCP3
3
Show member pathways
10.9GHRL, ADRB2, POMC, MC4R, FFAR4, PYY
4
Show member pathways
10.8PPARG, ADRB2, POMC, ADRB3, UCP1
510.7SDC3, MC4R, POMC, AGRP
610.7MC4R, ADRB3, POMC, ADRB2
7
Show member pathways
10.7PPARG, MT-CYB, UCP1, UCP3
810.7UCP3, PPARG, PPARGC1B
9
Show member pathways
10.6GHRL, FFAR4, POMC
1010.6ADRB2, PYY
11
Show member pathways
10.6UCP3, UCP1

Compounds for genes affiliated with Obesity

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Compounds related to Obesity according to GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1glucose4311.7UCP3, ADRB3, ADRB2, MT-CYB, GHRL, UCP1
2lipid4311.5PPARG, UCP1, ENPP1, NR0B2, UCP3, GHRL
3fatty acid4311.5AGRP, UCP1, UCP3, GHRL, ADRB3, PYY
4cholesterol43 28 24 1214.4NR0B2, UCP1, UCP3, GHRL, ADRB3, MC4R
5estrogen4311.4NR0B2, PPARG, ADRB3, PYY, ADRB2, UCP3
6alanine4311.4ADRB3, GHRL, MT-CYB, PPARG, UCP1, MC4R
7norepinephrine43 24 1213.3UCP1, UCP3, GHRL, ADRB2, ADRB3, POMC
82-deoxyglucose43 1212.3PPARG, PYY, POMC, GHRL, UCP3, AGRP
9nitric oxide43 24 1213.3UCP1, MT-CYB, MC4R, ADRB3, GHRL, UCP3
10cocaine43 1212.3ADRB2, POMC, MC4R, AGRP, PYY, GHRL
11atp43 2812.3PYY, UCP1, ADRB3, ENPP1, AGRP, UCP3
12hydrogen43 2412.2ADRB2, MT-CYB, UCP3, UCP1, PYY, GHRL
13cyclic amp43 2412.2ENPP1, PYY, GHRL, UCP1, ADRB2, ADRB3
14amphetamine43 49 1213.2GHRL, AGRP, POMC, MC4R, PYY
15clozapine43 28 49 1214.2GHRL, ADRB2, MC4R, ADRB3, POMC
16acth4311.2AGRP, GHRL, PYY, POMC, MC4R
17dexamethasone43 49 28 1214.2ADRB3, ENPP1, PPARG, POMC, ADRB2, GHRL
18opiate4311.1ADRB2, POMC, MC4R, GHRL
19metformin43 49 1213.1PPARG, GHRL, POMC, ENPP1
20c-peptide4311.1PYY, ADRB3, UCP1, GHRL
21triiodothyronine4311.1GHRL, POMC, UCP3, UCP1
22catecholamine4311.1POMC, ADRB3, ADRB2, UCP1
23palmitate4311.1UCP1, PPARG, MC4R, UCP3
24gtp43 2812.1UCP3, UCP1, MT-CYB, ADRB2, PYY
25rosiglitazone28 43 49 24 1215.1UCP1, GHRL, PPARG, UCP3
26arginine4311.1GHRL, MC4R, PYY, POMC, ADRB3, ADRB2
27alpha msh4311.1MC4R, POMC, AGRP
285-hydroxytryptamine4311.1ADRB2, PYY, POMC, GHRL
29intralipid4311.0PYY, UCP3, GHRL
30oxyntomodulin43 5912.0GHRL, AGRP, PYY
31thyroxine43 2412.0PPARG, GHRL, UCP1, POMC
32orlistat43 59 1213.0PPARG, GHRL, PYY
33thiazolidinedione4311.0PPARG, UCP1, UCP3
34dopamine43 28 24 1214.0PYY, GHRL, ADRB2, POMC, MC4R
35salbutamol43 49 28 24 1215.0UCP3, ADRB2, ADRB3
36carazolol43 2811.9ADRB2, ADRB3
37ici 1185512810.9ADRB2, ADRB3
38sr59230a2810.9ADRB3, ADRB2
39isoprenaline2810.9ADRB3, ADRB2
40bezafibrate43 28 1212.9PPARG, UCP3, UCP1
41[125i]icyp2810.9ADRB3, ADRB2
42cgp 1217728 4311.8ADRB3, ADRB2
43bupranolol28 43 1212.8ADRB2, ADRB3
44nadolol43 28 1212.7ADRB2, ADRB3
45gaba4310.7PYY, GHRL, POMC, ADRB2
46procaterol43 28 1212.7ADRB3, ADRB2
47pgc14310.7PPARG, UCP1
48naloxone43 28 49 1213.7POMC, ADRB2, GHRL
49gnrh4310.6POMC, PYY, ADRB2, GHRL
50oxygen43 2411.5GHRL, UCP3, UCP1, ADRB3, MT-CYB, ADRB2

GO Terms for genes affiliated with Obesity

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Cellular components related to Obesity according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:000561510.8AGRP, ENPP1, GHRL, POMC, PYY
2secretory granule lumenGO:003477410.3GHRL, POMC

Biological processes related to Obesity according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1brown fat cell differentiationGO:005087311.0UCP1, ADRB2, ADRB3, PPARG
2response to coldGO:000940911.0PPARG, ADRB3, ADRB2, UCP3
3feeding behaviorGO:000763111.0AGRP, MC4R, PYY, MRAP2
4diet induced thermogenesisGO:000202411.0MC4R, ADRB3, ADRB2
5eating behaviorGO:004275511.0AGRP, ADRB3, PYY
6adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:000718810.9MC4R, ADRB3, ADRB2
7response to insulinGO:003286810.9AGRP, UCP3, MC4R
8heat generationGO:003164910.9ADRB3, ADRB2
9generation of precursor metabolites and energyGO:000609110.9POMC, ADRB3, ENPP1
10desensitization of G-protein coupled receptor protein signaling pathway by arrestinGO:000203210.9ADRB3, ADRB2
11vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:000202510.8ADRB3, ADRB2
12energy reserve metabolic processGO:000611210.8MRAP2, MC4R, ADRB3
13adrenergic receptor signaling pathwayGO:007187510.8ADRB2, ADRB3
14adult feeding behaviorGO:000834310.8AGRP, GHRL
15negative regulation of multicellular organism growthGO:004001510.7ADRB2, ADRB3
16positive regulation of bone resorptionGO:004578010.7MC4R, PPARGC1B
17mitochondrial transportGO:000683910.6UCP3, UCP1
18proton transportGO:001599210.6UCP1, UCP3
19hormone-mediated signaling pathwayGO:000975510.5AGRP, GHRL
20activation of adenylate cyclase activityGO:000719010.3ADRB2, ADRB3

Molecular functions related to Obesity according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1oxidative phosphorylation uncoupler activityGO:001707710.8UCP1, UCP3
2type 1 melanocortin receptor bindingGO:007099610.7POMC, MRAP2
3norepinephrine bindingGO:005138010.7ADRB3, ADRB2
4type 4 melanocortin receptor bindingGO:003178210.7MRAP2, POMC
5G-protein coupled receptor bindingGO:000166410.6GHRL, POMC
6type 3 melanocortin receptor bindingGO:003178110.6MRAP2, POMC
7retinoid X receptor bindingGO:004696510.5NR0B2, PPARG
8neuropeptide hormone activityGO:000518410.3AGRP, PYY

Products for genes affiliated with Obesity

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Obesity

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet