MCID: OBS002
MIFTS: 71

Obsessive-Compulsive Disorder malady

Neuronal category

Summaries for Obsessive-Compulsive Disorder

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Obsessive-compulsive disorder (ocd) is a type of anxiety disorder. if you have ocd, you have frequent, upsetting thoughts called obsessions. to try to control the thoughts, you feel an overwhelming urge to repeat certain rituals or behaviors. these are called compulsions. examples of obsessions are a fear of germs or a fear of being hurt. compulsions include washing your hands, counting, checking on things, or cleaning. with ocd, the thoughts and rituals cause distress and get in the way of your daily life. researchers think brain circuits may not work properly in people who have ocd. it tends to run in families. the symptoms often begin in children or teens. treatments include therapy, medicines, or both. one type of therapy, cognitive behavioral therapy, is useful for treating ocd. nih: national institute of mental health

MalaCards: Obsessive-Compulsive Disorder, also known as obsessive compulsive disorder, is related to obsessive-compulsive personality disorder and anxiety disorder. An important gene associated with Obsessive-Compulsive Disorder is OCD1 (obsessive-compulsive disorder 1), and among its related pathways are phenylalanine utilization and Enzymatic degradation of dopamine by COMT. The drugs citalopram and citalopram hydrobromide and the compounds ketanserin and venlafaxine have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and cortex, and related mouse phenotypes are cardiovascular system and growth/size.

Disease Ontology:8 An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions).

Wikipedia:64 Obsessive–compulsive disorder (OCD) is an anxiety disorder characterized by intrusive thoughts that... more...

Description from OMIM:47 164230

Aliases & Classifications for Obsessive-Compulsive Disorder

Sources:
8Disease Ontology, 47OMIM, 45Novoseek, 34MedlinePlus, 61UMLS, 22GTR, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

obsessive-compulsive disorder 8 47 45 34 61
obsessive compulsive disorder 8 22
anancastic neurosis 8


External Ids:

Disease Ontology8 DOID:10933
MeSH35 D009771
ICD9CM27 300.3
ICD1025 F42

Related Diseases for Obsessive-Compulsive Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Obsessive-Compulsive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1obsessive-compulsive personality disorder31.4SLC6A4
2anxiety disorder31.3TPH1, SLC6A4, MAOA, HTR3A, BDNF
3panic disorder31.3HTR1A, HTR3A, SLC6A4, TSPO
4generalized anxiety disorder31.1HTR1A, SLC6A4, TSPO
5pathological gambling31.0SLC6A3, DRD4, DRD3, DRD1
6bipolar disorder31.0SLC6A4, HTR2A, HTR3A
7social phobia31.0COMT, HTR1A, HTR3A, MAOA, SLC6A4
8agoraphobia31.0HTR1A, MAOA
9anorexia nervosa30.9HTR2A, BDNF
10attention deficit hyperactivity disorder30.8DRD4, SLC6A3
11schizoaffective disorder30.7SLC6A4, DRD4, DRD3, HTR2A, BDNF, COMT
12myoclonus-dystonia30.5SGCE
13autistic disorder30.5BDNF, DRD4, SLC6A4
14seasonal affective disorder30.5HTR1A, HTR2A, DRD4, SLC6A4, TPH1
15alcohol dependence30.5SLC6A4, MAOA, DRD4, DRD1, HTR2A, HTR1B
16bulimia nervosa30.5COMT, SLC6A4, MAOA, HTR2A, HTR3A, HTR1B
17memory impairment30.5BDNF, PDYN, HTR1A, HTR2A, DRD1, SLC6A3
18gilles de la tourette syndrome30.3SLC6A3, DRD4
19narcolepsy30.3DRD1, HTR2A, COMT
20serotonin syndrome30.3HTR1A, HTR3A, HTR2A, MAOA
21paranoid schizophrenia30.3COMT
22drug addiction30.3BDNF, PDYN, DRD1, DRD3, SLC6A3
23temporal lobe epilepsy30.3BDNF, PDYN, HTR1A, SLC1A1, TSPO
24parkinson's disease30.3SLC6A3, MAOA, DRD3, HTR1A, PDYN, BDNF
25mental retardation30.3TPH1, MAOA, HTR3A, BDNF, COMT
26amyotrophic lateral sclerosis30.3BDNF, HTT, SLC6A3, TSPO
27alzheimer's disease30.3HTT, HTR2A, HTR1A, PDYN, BDNF, COMT
28trichotillomania10.9
29body dysmorphic disorder10.9
30hypochondriasis10.7
31schizotypal personality disorder10.6
32alexithymia10.6
33sleep disorder10.6
34tic disorder10.5
35major depressive disorder10.5
36asperger syndrome10.5
37bipolar i disorder10.5
38obsessive-compulsive disorder, protection against10.5
39adjustment disorder10.4
40pain disorder10.4
41n syndrome10.4
42scurvy10.4
43autism spectrum disorder10.4
44charge syndrome10.4
45pandas10.4
46myoclonus10.4
47transsexualism10.2
48normal pressure hydrocephalus10.2
49lateral sclerosis10.2
50williams-beuren syndrome10.2

Graphical network of the top 20 diseases related to Obsessive-Compulsive Disorder:



Diseases related to obsessive-compulsive disorder

Clinical Features for Obsessive-Compulsive Disorder

Sources:
47OMIM
See all sources

Clinical features from OMIM:

164230

Drugs & Therapeutics for Obsessive-Compulsive Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Obsessive-Compulsive Disorder

Drug clinical trials:

Search ClinicalTrials for Obsessive-Compulsive Disorder

Search NIH Clinical Center for Obsessive-Compulsive Disorder

Search CenterWatch for Obsessive-Compulsive Disorder

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Obsessive-Compulsive Disorder

Sources:
22GTR
See all sources

Genetic tests related to Obsessive-Compulsive Disorder:

id Genetic test Affiliating Genes
1 Obsessive-compulsive Disorder22

Anatomical Context for Obsessive-Compulsive Disorder

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Obsessive-Compulsive Disorder:

33
Skin, Brain, Cortex, T cells, B cells, Prefrontal cortex, Cingulate cortex, Parietal lobe, Temporal lobe, Thalamus, Hypothalamus, Subthalamic nucleus, Caudate nucleus, Amygdala, Pons, Adrenal cortex, Pineal, Pituitary

Animal Models for Obsessive-Compulsive Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Obsessive-Compulsive Disorder

Sources:
51PubMed
See all sources

Articles related to Obsessive-Compulsive Disorder:

(show top 50)    (show all 933)
idTitleAuthorsYear
1
Pharmacological treatment strategies in obsessive compulsive disorder: A cross-sectional view in nine international OCD centers. (24429223)
2014
2
Amygdala activation and symptom dimensions in obsessive-compulsive disorder. (24262816)
2014
3
Abnormal processing of deontological guilt in obsessive-compulsive disorder. (23681167)
2013
4
Neurological soft signs in obsessive-compulsive disorder: two empirical studies and meta-analysis. (22932491)
2013
5
Outcome of patients with chronic migraine with medication overuse and depression after duloxetine: influence of coexisting obsessive compulsive disorder. (23695074)
2013
6
Symptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder. (23298952)
2013
7
Let me check that for you: symptom accommodation in romantic partners of adults with Obsessive-Compulsive Disorder. (23567474)
2013
8
Phenomenology and correlates of insight in pediatric obsessive-compulsive disorder. (24238933)
2013
9
Outcomes of specialized residential treatment for adults with obsessive-compulsive disorder. (24042250)
2013
10
Augmenting obsessive-compulsive disorder treatment: from brain to mind. (24026506)
2013
11
Cognitive behavioral therapy for pediatric obsessive-compulsive disorder: development of expert-level competence and implications for dissemination. (24128870)
2013
12
Ondansetron augmentation in patients with obsessive-compulsive disorder who are inadequate responders to serotonin reuptake inhibitors: Improvement with treatment and worsening following discontinuation. (24406025)
2013
13
Obsessive compulsive disorder in veterans in primary care: prevalence and impairment. (23044243)
2013
14
A blind re-analysis of the Iowa family study of obsessive-compulsive disorder. (23676614)
2013
15
Treatment response, symptom remission, and wellness in obsessive-compulsive disorder. (23945445)
2013
16
An exploratory dimensional approach to premenstrual manifestation of obsessive-compulsive disorder symptoms: a multicentre study. (23497833)
2013
17
EEG-vigilance regulation during the resting state in obsessive-compulsive disorder. (23022038)
2013
18
A case report of obsessive-compulsive disorder following acute disseminated encephalomyelitis. (23918895)
2013
19
Obsessive-compulsive personality disorder co-occurring with obsessive-compulsive disorder: Conceptual and clinical implications. (22689335)
2013
20
Improvements in anorexia symptoms after deep brain stimulation for intractable obsessive-compulsive disorder. (23128051)
2013
21
Ritualistic chewing behavior induced by mCPP in the rat is an animal model of obsessive compulsive disorder. (23333679)
2013
22
Active stimulation site of nucleus accumbens deep brain stimulation in obsessive-compulsive disorder is localized in the ventral internal capsule. (23652657)
2013
23
Contextual and behavioral influences on uncertainty in obsessive-compulsive disorder. (23318087)
2012
24
Neuropsychological predictors of response to randomized treatment in obsessive-compulsive disorder. (22789662)
2012
25
Pilot study on HTR2A promoter polymorphism, -1438G/A (rs6311) and a nearby copy number variation showed association with onset and severity in early onset obsessive-compulsive disorder. (21874579)
2012
26
Association between the NMDA glutamate receptor GRIN2B gene and obsessive-compulsive disorder. (22433450)
2012
27
Error-related negativity abnormalities in generalized anxiety disorder and obsessive-compulsive disorder. (21111024)
2011
28
Relapse prevention and residual symptoms: a closer analysis of placebo-controlled continuation studies with escitalopram in major depressive disorder, generalized anxiety disorder, social anxiety disorder, and obsessive-compulsive disorder. (19961809)
2010
29
Comorbidity of obsessive-compulsive disorder with obsessive-compulsive personality disorder: Does it imply a specific subtype of obsessive-compulsive disorder? (20163876)
2010
30
Aripiprazole treatment in an adolescent patient with chronic motor tic disorder and treatment-resistant obsessive-compulsive disorder. (19706223)
2009
31
Obsessive-compulsive personality disorder and suicidal behavior: evidence for a positive association in a sample of depressed patients. (19607764)
2009
32
A comparative study of obsessive-compulsive disorder and other psychiatric comorbidities in patients with temporal lobe epilepsy and idiopathic generalized epilepsy. (19435590)
2009
33
Serum selenium and plasma malondialdehyde levels and antioxidant enzyme activities in patients with obsessive-compulsive disorder. (18957313)
2009
34
Motor inhibition in trichotillomania and obsessive-compulsive disorder. (17215004)
2008
35
The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessive-compulsive disorder. (18339223)
2008
36
Body dysmorphic disorder and obsessive-compulsive disorder: similarities, differences and the classification debate. (18671665)
2008
37
Clarifying the convergence between obsessive compulsive personality disorder criteria and obsessive compulsive disorder. (16776557)
2006
38
Obsessive compulsive behavior, hyperactivity, and attention deficit disorder in Sydenham chorea. (15911817)
2005
39
No association between brain-derived neurotrophic factor gene and obsessive-compulsive disorder. (16314750)
2005
40
Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathway. (15206000)
2004
41
Asperger Syndrome, obsessive-compulsive disorder, and major depression in a patient with 45,X/46,XY mosaicism. (15153741)
2004
42
Myelin oligodendrocyte glycoprotein (MOG) gene is associated with obsessive-compulsive disorder. (15274043)
2004
43
Gender identity disorder presenting in a girl with Asperger's disorder and obsessive compulsive disorder. (12971211)
2003
44
No association between obsessive-compulsive disorder and the 5-HT(1Dbeta) receptor gene. (12359689)
2002
45
A 45-year-old woman with obsessive-compulsive disorder, 1 year later. (11866653)
2002
46
Effects of axis I and II comorbidity on behavior therapy outcome for obsessive-compulsive disorder and agoraphobia. (11154720)
2001
47
Serotonergic function in social phobia: comparison to normal control and obsessive-compulsive disorder subjects. (9704868)
1998
48
Dopamine D2 and D4 receptor genes distinguish the clinical presence of tics in obsessive-compulsive disorder]. (9842133)
1998
49
Magnetic resonance brain imaging in women with obsessive-compulsive disorder and trichotillomania. (9255863)
1997
50
Concomitant obsessive-compulsive disorder and schizotypal personality disorder. (3953896)
1986

Genetic Variations for Obsessive-Compulsive Disorder

Expression for genes affiliated with Obsessive-Compulsive Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Obsessive-Compulsive Disorder

Search GEO for disease gene expression data for Obsessive-Compulsive Disorder.

Pathways for genes affiliated with Obsessive-Compulsive Disorder

Sources:
38NCBI BioSystems Database, 54Reactome, 50PharmGKB, 4Cell Signaling Technology, 52QIAGEN, 30KEGG
See all sources

Pathways related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4MAOA, COMT
2
Hide members
10.4SLC6A3, MAOA
310.4DRD4, DRD3, HTR2A
410.4DRD1, DRD3, DRD4
5
Hide members
10.4DRD4, DRD3, DRD1
610.4HTR1A, HTT, SLC1A1, TPH1
7
Hide members
10.3COMT, MAOA, SLC6A3, SLC1A1
8
Hide members
10.3BDNF, DRD1, DRD3, DRD4
9
Hide members
10.3HTR2A, HTR3A, HTR1A, HTR1B, BDNF
1010.3BDNF, PDYN, DRD1, MAOA, SLC6A3
11
Hide members
10.3SLC6A3, MAOA, DRD1, PDYN, BDNF
1210.3BDNF, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
13
Hide members
10.2PDYN, HTR1B, HTR1A, HTR2A, DRD1, DRD3
14
Hide members
10.2SLC6A4, MAOA, DRD4, DRD3, DRD1, HTR2A
15
Hide members
10.1SLC1A1, COMT, HTR1B, SLC6A4, SLC6A3, MAOA

Compounds for genes affiliated with Obsessive-Compulsive Disorder

Sources:
29IUPHAR, 45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 318)
idCompoundScoreTop Affiliating Genes
1ketanserin29 4511.7SLC6A4, HTR2A, HTR3A, HTR1A, HTR1B, BDNF
2venlafaxine50 45 11 2413.7HTR2A, HTR3A, HTR1A, HTR1B, BDNF, SLC6A3
3cabergoline29 45 1112.7HTR1A, DRD4, DRD3, DRD1, HTR2A, COMT
4ropinirole45 1111.7COMT, DRD4, DRD3, DRD1, HTR2A, HTR1A
5pergolide29 45 1112.7DRD3, DRD1, HTR2A, HTR1A, HTR1B, COMT
6apomorphine45 29 1112.7HTR2A, HTR1A, HTR1B, COMT, DRD1, DRD3
7fluoxetine50 45 29 1113.6SLC6A4, SLC6A3, MAOA, HTR2A, HTR3A, HTR1A
8fluvoxamine45 50 1112.6HTR2A, HTR3A, HTR1A, BDNF, MAOA, SLC6A3
9citalopram50 45 11 2413.6BDNF, HTR1A, HTR3A, HTR2A, MAOA, SLC6A3
10bromocriptine29 45 1112.6COMT, SLC6A3, DRD4, DRD3, DRD1, HTR2A
11maoa4510.6TPH1, SLC6A4, SLC6A3, MAOA, DRD4, HTR2A
12clomipramine45 50 1112.6MAOA, SLC6A3, SLC6A4, TSPO, HTR2A, HTR3A
13pramipexole45 50 29 1113.6BDNF, COMT, HTR1B, HTR1A, SLC6A3, DRD4
14quetiapine45 50 29 11 2414.6DRD1, HTR2A, HTR3A, HTR1A, HTR1B, BDNF
156-hydroxydopamine4510.6PDYN, DRD1, DRD3, DRD4, MAOA, SLC6A3
16raclopride45 2911.6HTR2A, DRD3, DRD4, HTR1A, SLC6A3, DRD1
17haloperidol45 29 2 50 1114.6SLC6A3, DRD4, DRD3, DRD1, HTR2A, HTR3A
18methamphetamine45 50 1112.6DRD1, PDYN, BDNF, COMT, DRD3, DRD4
19aripiprazole29 50 45 11 2414.6HTR2A, DRD1, DRD3, HTR1A, HTR1B, HTR3A
20mptp4510.6COMT, BDNF, DRD1, DRD3, MAOA, SLC6A3
21spiperone29 4511.6DRD1, HTR2A, HTR3A, HTR1A, DRD3, DRD4
22risperidone29 45 50 60 11 2415.6DRD1, HTR2A, HTR3A, HTR1A, HTR1B, BDNF
23methylphenidate45 50 1112.6SLC6A3, SLC6A4, DRD4, DRD1, COMT, MAOA
24ziprasidone50 29 45 1113.6DRD3, DRD1, HTR2A, HTR3A, HTR1A, HTR1B
25olanzapine50 45 29 11 2414.6DRD1, HTR2A, HTR3A, HTR1A, HTR1B, BDNF
26clozapine45 29 50 1113.6SLC6A4, SLC6A3, DRD4, DRD3, DRD1, HTR2A
27paroxetine45 50 29 1113.6TPH1, SLC6A4, SLC6A3, MAOA, DRD4, DRD3
28imipramine45 50 29 11 2414.5SLC6A3, SLC6A4, MAOA, DRD3, BDNF, DRD1
29lisuride29 45 1112.5HTR2A, HTR1A, HTR1B, DRD4, DRD3, DRD1
30nmda45 2911.5COMT, TSPO, PDYN, HTR1A, HTT, MAOA
31fenfluramine29 45 1112.5SLC6A4, HTR1B, HTR2A, HTR3A, HTR1A, TPH1
32chlorpromazine45 29 50 1113.5HTR3A, DRD4, DRD3, DRD1, HTR2A, BDNF
335-hydroxytryptamine4510.5COMT, HTR1B, HTR1A, HTR3A, HTR2A, DRD4
34carbon-114510.5TSPO, MAOA, HTR1A, SLC6A4, SLC6A3
35cocaine45 1111.5COMT, BDNF, PDYN, HTR1B, DRD1, DRD3
36gaba4510.5MAOA, SLC6A3, SLC6A4, SLC1A1, TSPO, TPH1
37nicotine45 50 29 1113.5DRD1, DRD3, DRD4, MAOA, SLC6A3, SLC6A4
38catecholamine4510.5PDYN, MAOA, COMT, TPH1, BDNF, DRD4
39iloperidone50 45 29 1113.4DRD1, HTR1A, HTR3A, HTR2A, DRD3, DRD4
40levodopa45 1111.4COMT, BDNF, PDYN, HTR1B, HTR1A, DRD1
41amphetamine45 1111.4SLC6A4, TPH1, SLC6A3, PDYN, DRD1, MAOA
42quinpirole45 2911.4HTR2A, DRD4, DRD3, DRD1, PDYN, SLC6A3
43norepinephrine45 11 2412.4COMT, BDNF, PDYN, HTR1A, HTR3A, HTR2A
44(+)-butaclamol29 4511.4HTR1A, HTR2A, DRD1, DRD3, DRD4
45glutamate4510.4MAOA, DRD4, SLC6A3, TSPO, TPH1, SLC6A4
46dopamine45 29 11 2413.4PDYN, HTR1B, DRD1, HTT, HTR2A, HTR3A
47d amphetamine4510.3MAOA, SLC6A3, SLC6A4, TSPO, DRD1
48asenapine29 1111.3DRD1, HTR1B, HTR1A, DRD4, DRD3, HTR2A
49heroin45 50 1112.2SLC6A4, COMT, PDYN, DRD4, SLC6A3, DRD3
50mcpp4510.0HTR2A, HTR3A, HTR1A, SLC6A4, HTR1B

GO Terms for genes affiliated with Obsessive-Compulsive Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:03042410.4SLC6A3, HTT, HTR2A, HTR3A
2integral to plasma membraneGO:00588710.0SGCE, HTR1B, HTR1A, HTR3A, HTR2A, DRD1
3plasma membraneGO:0058869.8HTR3A, HTR1A, HTR1B, PDYN, COMT, HTR2A

Biological processes related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1regulation of behaviorGO:05079510.8HTR1B, HTR1A, HTR2A
2serotonin receptor signaling pathwayGO:00721010.8HTR1A, HTR3A, HTR2A
3regulation of dopamine secretionGO:01405910.8HTR1B, HTR2A, DRD3
4adenylate cyclase-inhibiting serotonin receptor signaling pathwayGO:00719810.8HTR1A, HTR1B
5dopamine catabolic processGO:04242010.8COMT, MAOA, SLC6A3
6regulation of hormone secretionGO:04688310.8HTR1A, HTR2A
7vasoconstrictionGO:04231010.8HTR1B, HTR1A, SLC6A4
8social behaviorGO:03517610.8SLC6A4, DRD4, DRD3, HTT
9dopamine metabolic processGO:04241710.8DRD1, DRD3, DRD4
10behavioral fear responseGO:00166210.8DRD4, DRD1, HTR1A, BDNF
11regulation of dopamine metabolic processGO:04205310.8SLC6A3, DRD4, DRD1, HTR1A
12response to histamineGO:03477610.8DRD3, DRD4
13behavioral response to cocaineGO:04814810.8DRD1, DRD3, DRD4
14response to cocaineGO:04222010.8HTR1B, HTR3A, DRD3, SLC6A3
15synaptic transmission, dopaminergicGO:00196310.8DRD1, DRD3, DRD4
16L-glutamate importGO:05193810.8HTT, SLC1A1
17neurotransmitter biosynthetic processGO:04213610.8SLC6A3, MAOA, COMT
18prepulse inhibitionGO:06013410.7DRD1, DRD3, SLC6A3
19regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD1, DRD3
20memoryGO:00761310.7SLC6A4, DRD1, HTR2A
21response to amphetamineGO:00197510.7DRD4, DRD3, DRD1
22monoamine transportGO:01584410.7SLC6A4, SLC6A3
23visual learningGO:00854210.7DRD3, DRD1, HTT
24dopamine transportGO:01587210.7DRD1, SLC6A3
25adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.7DRD3, DRD4
26neurotransmitter catabolic processGO:04213510.7MAOA, COMT
27dopamine receptor signaling pathwayGO:00721210.7DRD4, HTT
28negative regulation of synaptic transmission, glutamatergicGO:05196710.7HTR2A, HTR1B
29response to drugGO:04249310.7COMT, HTR2A, DRD1, DRD3, SLC6A3, SLC6A4
30synaptic transmissionGO:00726810.7COMT, PDYN, HTR1B, HTR3A, HTR2A, MAOA
31locomotory behaviorGO:00762610.7HTT, DRD3, SLC6A3
32negative regulation of cAMP biosynthetic processGO:03081810.6HTR1B, DRD4
33cellular calcium ion homeostasisGO:00687410.6HTR2A, DRD3, DRD4
34striatum developmentGO:02175610.6HTT, DRD1
35response to ethanolGO:04547110.6SLC6A3, DRD3, HTR1B
36adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD1, DRD3
37G-protein coupled receptor internalizationGO:00203110.5DRD3, HTR1B
38negative regulation of protein secretionGO:05070910.5DRD4, DRD3
39temperature homeostasisGO:00165910.4DRD1, HTR2A
40agingGO:00756810.4HTR2A, TSPO
41bone remodelingGO:04684910.3TPH1, HTR1B
42arachidonic acid secretionGO:05048210.1DRD4, DRD3

Molecular functions related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.5SLC6A3, DRD4, DRD3, DRD1
2drug bindingGO:00814410.4HTR1B, HTR2A, DRD3, DRD4, SLC6A3
3serotonin receptor activityGO:00499310.4HTR1B, HTR1A, HTR3A, HTR2A
4monoamine transmembrane transporter activityGO:00850410.4SLC6A4, SLC6A3
5serotonin bindingGO:05137810.4HTR2A, HTR3A, HTR1B
6dopamine neurotransmitter receptor activityGO:00495210.3DRD1, DRD4
7dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.1DRD3, DRD4

Products for genes affiliated with Obsessive-Compulsive Disorder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Obsessive-Compulsive Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet