MCID: OBS002
MIFTS: 69

Obsessive-Compulsive Disorder malady

Genetic diseases (common), Mental diseases, Neuronal diseases categories

Summaries for Obsessive-Compulsive Disorder

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MedlinePlus:32 Obsessive-compulsive disorder (ocd) is a type of anxiety disorder. if you have ocd, you have frequent, upsetting thoughts called obsessions. to try to control the thoughts, you feel an overwhelming urge to repeat certain rituals or behaviors. these are called compulsions. examples of obsessions are a fear of germs or a fear of being hurt. compulsions include washing your hands, counting, checking on things, or cleaning. with ocd, the thoughts and rituals cause distress and get in the way of your daily life. researchers think brain circuits may not work properly in people who have ocd. it tends to run in families. the symptoms often begin in children or teens. treatments include therapy, medicines, or both. one type of therapy, cognitive behavioral therapy, is useful for treating ocd. nih: national institute of mental health

MalaCards based summary: Obsessive-Compulsive Disorder, also known as obsessive-compulsive disorder, protection against, is related to obsessive-compulsive personality disorder and generalized anxiety disorder, and has symptoms including autosomal dominant inheritanceand obsessive-compulsive behavior. An important gene associated with Obsessive-Compulsive Disorder is SLC6A4 (solute carrier family 6 (neurotransmitter transporter), member 4), and among its related pathways are Serotonin clearance from the synaptic cleft and Dopamine metabolism. The drugs citalopram and clomipramine and the compounds mcpp and lisuride have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are taste/olfaction and endocrine/exocrine gland.

Disease Ontology:9 An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions).

OMIM:45 Obsessive-compulsive disorder (OCD) is characterized by recurring obsessions and/or compulsions and has been estimated... (164230) more...

Wikipedia:63 Obsessive?compulsive disorder (OCD) is an anxiety disorder characterized by intrusive thoughts that... more...

Aliases & Classifications for Obsessive-Compulsive Disorder

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Obsessive-Compulsive Disorder, Aliases & Descriptions:

Name: Obsessive-Compulsive Disorder 45 9 43 32 60
Obsessive-Compulsive Disorder, Protection Against 45 10
 
Obsessive Compulsive Disorder 9 22
Anancastic Neurosis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Mental diseases, Neuronal diseases


External Ids:

OMIM45 164230
Disease Ontology9 DOID:10933
MeSH33 D009771
ICD9CM27 300.3
ICD1025 F42

Related Diseases for Obsessive-Compulsive Disorder

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Diseases related to Obsessive-Compulsive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1obsessive-compulsive personality disorder32.1SLC6A4
2generalized anxiety disorder31.8SLC6A4, HTR1A
3anorexia nervosa31.7HTR2A, BDNF
4panic disorder31.6HTR1A, HTR3A, SLC6A4
5schizophrenia31.4DRD3, COMT, HTR2A
6gilles de la tourette syndrome31.4DRD4, SLC6A3
7agoraphobia31.3MAOA, HTR1A
8bipolar disorder31.3HTR3A, HTR2A, SLC6A4
9anxiety disorder31.3TPH1, HTR3A, MAOA, BDNF, SLC6A4
10attention deficit-hyperactivity disorder31.3SLC6A3, DRD4
11intermittent explosive disorder31.1HTR1B
12paranoid schizophrenia31.0COMT
13autistic disorder31.0SLC6A4, BDNF, DRD4
14social phobia30.9HTR1A, MAOA, SLC6A4, COMT, HTR3A
15dysthymic disorder30.8HTR2A, MAOA
16pathological gambling30.8DRD4, DRD3, DRD1, SLC6A3
17narcolepsy30.8COMT, DRD1, HTR2A
18temporal lobe epilepsy30.5SLC1A1, PDYN, BDNF, HTR1A
19personality disorder30.5SLC6A3, SLC6A4, TPH1, HTR1B, MAOA, DRD4
20alcohol dependence30.4SLC6A4, DRD4, MAOA, HTR1B, HTR2A, DRD1
21eating disorder30.4HTR3A, HTR1A, HTR2A, COMT, BDNF, SLC6A4
22serotonin syndrome30.3MAOA, HTR2A, HTR1A, HTR3A
23bulimia nervosa30.2HTR2A, HTR1B, HTR3A, COMT, MAOA, BDNF
24essential tremor30.2SLC6A3, DRD3
25mental retardation30.1BDNF, TPH1, COMT, HTR3A, MAOA
26drug addiction29.8SLC6A3, BDNF, DRD3, PDYN, DRD1
27drug dependence29.7PDYN, SLC6A3, DRD3, MAOA, SLC6A4
28dementia29.2COMT, MAOA, HTR1A, BDNF, SLC6A3, HTR3A
29mood disorder28.4SLC6A4, BDNF, DRD1, DRD3, DRD4, PDYN
30migraine28.3SLC6A3, SLC6A4, DRD1, DRD3, DRD4, MAOA
31psychotic disorder28.3SLC6A3, SLC6A4, BDNF, DRD1, DRD3, DRD4
32trichotillomania11.0
33body dysmorphic disorder11.0
34tic disorder10.8
35hypochondriasis10.8
36blindness10.7
37neuronitis10.7
38chronic tic disorder10.6
39schizotypal personality disorder10.6
40alexithymia10.6
41dystonia10.6
42alcoholic psychosis10.6SLC6A4
43heroin dependence10.5DRD4
44cerebritis10.5
45delusional disorder10.5DRD4
46neuroleptic malignant syndrome10.5HTR1A
47asperger syndrome10.5
48bipolar i disorder10.5
49nicotine dependence, protection against10.4SLC6A4, DRD4
50premature ejaculation10.4HTR1A, SLC6A4

Graphical network of the top 20 diseases related to Obsessive-Compulsive Disorder:



Diseases related to obsessive-compulsive disorder

Symptoms for Obsessive-Compulsive Disorder

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Symptoms by clinical synopsis from OMIM:

164230

Clinical features from OMIM:

164230

HPO human phenotypes related to Obsessive-Compulsive Disorder:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 obsessive-compulsive behavior HP:0000722

Drugs & Therapeutics for Obsessive-Compulsive Disorder

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Genetic Tests for Obsessive-Compulsive Disorder

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Genetic tests related to Obsessive-Compulsive Disorder:

id Genetic test Affiliating Genes
1 Obsessive-Compulsive Disorder22

Anatomical Context for Obsessive-Compulsive Disorder

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MalaCards organs/tissues related to Obsessive-Compulsive Disorder:

31
Brain, Cortex, Testes, Prefrontal cortex, Thalamus, Skin, Subthalamic nucleus, Pineal, Pituitary, Eye, B cells, Cingulate cortex, Temporal lobe, Hypothalamus, Amygdala, Pons

Animal Models for Obsessive-Compulsive Disorder or affiliated genes

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MGI Mouse Phenotypes related to Obsessive-Compulsive Disorder:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053948.9BDNF, HTT, SLC6A3
2MP:00053798.2SLC6A3, SLC6A4, HTT, HTR3A, HTR1B, HTR2A
3MP:00053898.1SLC6A3, BDNF, COMT, HTT, HTR1B, HTR3A
4MP:00053908.0SLC6A3, PDYN, HTT, HTR1B, HTR2A, TPH1
5MP:00053697.6HTR1B, SGCE, TPH1, HTR2A, SLC6A3, SLC6A4
6MP:00107717.4HTT, TPH1, HTR3A, PDYN, SLC6A3, SLC6A4
7MP:00053857.1DRD1, SGCE, HTR1B, HTR1A, COMT, TPH1
8MP:00053786.6HTR3A, HTR1B, TPH1, HTT, DRD3, DRD1
9MP:00036315.1MAOA, SLC6A3, SGCE, HTR3A, HTT, HTR1A
10MP:00053765.0DRD3, DRD4, PDYN, MAOA, COMT, HTR1A
11MP:00053864.3SLC6A3, HTR2A, TPH1, SGCE, HTR3A, HTT

Publications for Obsessive-Compulsive Disorder

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Articles related to Obsessive-Compulsive Disorder:

(show top 50)    (show all 925)
idTitleAuthorsYear
1
Whole-genome association analysis of treatment response in obsessive-compulsive disorder. (25824302)
2015
2
Comorbid obsessive compulsive disorder in patients with bipolar-I disorder. (25545603)
2015
3
L-3,4-Dihydroxy-6-[F-18]fluorophenylalanine positron emission tomography demonstrating dopaminergic system abnormality in the brains of obsessive-compulsive disorder patients. (24405478)
2014
4
Paediatric Obsessive-Compulsive Disorder and Depressive Symptoms: Clinical Correlates and CBT Treatment Outcomes. (25301176)
2014
5
Moral rigidity in obsessive-compulsive disorder: do abnormalities in inhibitory control, cognitive flexibility and disgust play a role? (24161700)
2014
6
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. (25035563)
2014
7
Discontinuous patterns of brain activation in the psychotherapy process of obsessive-compulsive disorder: converging results from repeated FMRI and daily self-reports. (23977168)
2013
8
Clinical features of pure obsessive-compulsive disorder. (23746710)
2013
9
Incompleteness as a Link between Obsessive-Compulsive Personality Traits and Specific Symptom Dimensions of Obsessive-Compulsive Disorder. (23650140)
2013
10
Cognitive Behavioural Therapy for Obsessive-Compulsive Disorder with Comorbid Schizophrenia: A Case Report with Repetitive Measurements. (23899371)
2013
11
Buprenorphine augmentation in the treatment of refractory obsessive-compulsive disorder. (23983988)
2013
12
Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder. (23200527)
2013
13
Pediatric obsessive-compulsive disorder: a review for nursing professionals. (23607826)
2013
14
Obsessive-compulsive disorder and cingulotomy. (23746096)
2013
15
Default network connectivity as a vulnerability marker for obsessive compulsive disorder. (24001350)
2013
16
Cognitive deficits of executive functions and decision-making in obsessive-compulsive disorder. (23841985)
2013
17
Is there a Role for Immunological Mechanisms in Etiopathogenesis of Obsessive Compulsive Disorder? (23833334)
2013
18
The relationship between obsessive-compulsive personality disorder traits, obsessive-compulsive disorder and excessive exercise in patients with anorexia nervosa: a systematic review. (24999397)
2013
19
Obsessive-compulsive disorder in dermatology. (24049965)
2013
20
Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights. (23326403)
2013
21
Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder. (23410525)
2013
22
Dissociative symptoms and dissociative disorder comorbidity in patients with obsessive-compulsive disorder. (22425531)
2012
23
Cognitive-behavioral therapy for obsessive-compulsive disorder as a comorbidity with schizophrenia or schizoaffective disorder. (22123432)
2012
24
Early sleep psychiatric intervention for acute insomnia: implications from a case of obsessive-compulsive disorder. (22505865)
2012
25
Contextual and behavioral influences on uncertainty in obsessive-compulsive disorder. (23318087)
2012
26
Schizophrenia and obsessive-compulsive disorder: from comorbidity to schizo-obsessive disorder. (22622247)
2012
27
Rage takes center stage: focus on an underappreciated aspect of pediatric obsessive-compulsive disorder. (22632616)
2012
28
Living with parents with obsessive-compulsive disorder: children's lives and experiences. (22903894)
2012
29
Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET study. (19660554)
2010
30
Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder. (20565924)
2010
31
Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder. (19578685)
2009
32
Clozapine in treatment-refractory obsessive-compulsive disorder with comorbid schizotypal personality disorder. (19398826)
2008
33
Screening of the epsilon sarcoglycan gene in Tourette syndrome and obsessive compulsive disorder. (18349702)
2008
34
Association study between the dopamine receptor D(4) gene and obsessive-compulsive disorder. (16996722)
2007
35
Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample. (18094849)
2007
36
Rare plus common SERT variants in obsessive-compulsive disorder. (17453059)
2007
37
Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. (15667435)
2005
38
Obsessive-compulsive disorder and body dysmorphic disorder: a comparison of clinical features. (15276662)
2004
39
Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. (15083261)
2004
40
Dopamine transporter density of basal ganglia assessed with [123I]IPT SPET in obsessive-compulsive disorder. (14513291)
2003
41
Obsessive compulsive disorder among idiopathic focal dystonia patients: an epidemiological and family study. (12208643)
2002
42
No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. (10088048)
1999
43
Serotonergic function in social phobia: comparison to normal control and obsessive-compulsive disorder subjects. (9704868)
1998
44
Magnetic resonance brain imaging in women with obsessive-compulsive disorder and trichotillomania. (9255863)
1997
45
Obsessive compulsive symptoms in Gilles de la Tourette syndrome and obsessive compulsive disorder: differences by diagnosis and family history. (9259380)
1997
46
Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. (9114031)
1997
47
DRD2, DRD3 and 5HT2A receptor genes polymorphisms in obsessive-compulsive disorder. (9154247)
1996
48
Fenfluramine stimulation of prolactin in obsessive-compulsive disorder. (1603884)
1992
49
Response of obsessive-compulsive disorder and trichotillomania to serotonin reuptake blockers. (1728180)
1992
50
Prolactin and cortisol responses to MK-212, a serotonin agonist, in obsessive-compulsive disorder. (2203327)
1990

Variations for Obsessive-Compulsive Disorder

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Expression for genes affiliated with Obsessive-Compulsive Disorder

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Search GEO for disease gene expression data for Obsessive-Compulsive Disorder.

Pathways for genes affiliated with Obsessive-Compulsive Disorder

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Pathways related to Obsessive-Compulsive Disorder according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5MAOA, COMT
29.5MAOA, COMT
39.5MAOA, COMT
49.5COMT, MAOA
59.5HTR2A, DRD3, DRD4
6
Show member pathways
Nicotine Activity on Dopaminergic Neurons36
9.3DRD3, DRD4, DRD1
79.2HTR1A, SLC1A1, HTT, TPH1
8
Show member pathways
catecholamine biosynthesis36
9.2MAOA, TPH1, COMT
9
Show member pathways
9.1DRD4, BDNF, DRD1, DRD3
10
Show member pathways
8.8BDNF, HTR1A, HTR3A, HTR1B, HTR2A
11
Show member pathways
8.8SLC6A3, BDNF, DRD1, HTT
12
Show member pathways
Serotonin Transporter Activity36
8.8SLC6A4, SLC6A3, MAOA
13
Show member pathways
8.5HTR2A, HTR1A, DRD1, DRD4, HTR1B, DRD3
14
Show member pathways
8.4MAOA, SLC6A3, COMT, SLC1A1
15
Show member pathways
8.0HTR1A, DRD1, DRD3, DRD4, PDYN, HTR2A
16
Show member pathways
8.0DRD3, DRD1, HTR1A, PDYN, HTR2A, HTR1B
17
Show member pathways
8.0MAOA, BDNF, DRD1, PDYN, SLC6A3
18
Show member pathways
8.0MAOA, SLC6A3, BDNF, DRD1, PDYN
197.9TPH1, HTR2A, HTR3A, HTR1A, SLC6A4, BDNF
207.9HTR2A, TPH1, SLC6A4, MAOA, HTR3A, HTR1B
21
Show member pathways
5.3DRD1, DRD3, DRD4, MAOA, COMT, HTR1A

Compounds for genes affiliated with Obsessive-Compulsive Disorder

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Compounds related to Obsessive-Compulsive Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 310)
idCompoundScoreTop Affiliating Genes
1mcpp438.9SLC6A4, HTR1A, HTR3A, HTR1B, HTR2A
2lisuride43 28 1210.7DRD3, HTR1A, HTR1B, DRD1, HTR2A, DRD4
3ketanserin43 289.7SLC6A4, BDNF, DRD1, HTR1A, HTR3A, HTR1B
4fenfluramine43 28 1210.6HTR1B, HTR1A, SLC6A4, HTR3A, TPH1, HTR2A
5spiperone43 289.6HTR1A, HTR3A, HTR2A, DRD4, DRD3, DRD1
6ropinirole43 129.5DRD1, DRD3, DRD4, COMT, HTR1A, HTR1B
7pergolide43 28 1210.5DRD1, DRD3, DRD4, COMT, HTR1A, HTR1B
8cabergoline43 28 1210.4COMT, HTR1A, HTR1B, HTR2A, DRD4, DRD1
9(+)-butaclamol43 289.4DRD4, HTR1A, HTR2A, DRD3, DRD1
10asenapine28 129.4DRD4, DRD3, HTR2A, HTR1B, HTR1A, DRD1
11ziprasidone28 49 43 1211.4DRD3, DRD4, HTR1A, HTR3A, HTR1B, HTR2A
12Serotonin248.4HTR1B, HTR3A, HTR1A, MAOA, SLC6A4, HTR2A
13aripiprazole28 43 49 24 1212.3DRD1, DRD3, DRD4, HTR1A, HTR3A, HTR1B
14methylphenidate43 49 1210.3SLC6A3, SLC6A4, DRD1, DRD4, MAOA, COMT
15raclopride43 289.3HTR1A, HTR2A, SLC6A3, DRD1, DRD3, DRD4
16chlorpromazine28 43 49 1211.3HTR2A, HTR3A, HTR1A, BDNF, DRD1, DRD3
17nefazodone43 49 1210.2HTR3A, HTR1A, SLC6A4, SLC6A3, HTR2A, HTR1B
18iloperidone49 43 28 1211.2DRD4, HTR3A, HTR2A, DRD1, HTR1A, DRD3
19heroin43 49 1210.0PDYN, COMT, DRD4, DRD3, BDNF, SLC6A3
20venlafaxine43 49 24 1210.9HTR2A, SLC6A3, SLC6A4, BDNF, COMT, HTR1A
21quinpirole43 288.9HTR2A, PDYN, DRD4, DRD3, DRD1, SLC6A3
22clomipramine43 49 129.9SLC6A3, SLC6A4, MAOA, HTR1A, HTR3A, HTR1B
23apomorphine28 43 129.6SLC6A3, DRD1, DRD3, DRD4, COMT, HTR1A
24amphetamine43 49 129.6SLC6A4, PDYN, DRD4, SLC6A3, MAOA, DRD1
25bromocriptine43 28 129.6COMT, DRD3, DRD4, HTR1A, HTR1B, HTR2A
26catecholamine437.6TPH1, COMT, MAOA, DRD4, DRD3, BDNF
27mptp437.6DRD3, SLC6A3, COMT, MAOA, DRD1, BDNF
28citalopram43 49 24 1210.5SLC6A4, BDNF, MAOA, HTR1A, HTR3A, HTR2A
29pramipexole43 28 49 1210.5DRD3, DRD4, COMT, HTR1A, HTR1B, HTR2A
30cocaine43 128.3DRD3, DRD1, BDNF, SLC6A4, SLC6A3, DRD4
31fluoxetine43 49 28 1210.3MAOA, HTR1A, HTR3A, HTR1B, HTR2A, TPH1
326-hydroxydopamine437.2BDNF, DRD1, DRD3, DRD4, PDYN, MAOA
33haloperidol43 49 28 2 1211.2HTR2A, HTR3A, SLC6A3, SLC6A4, BDNF, DRD1
34maoa437.2SLC6A3, SLC6A4, BDNF, DRD4, MAOA, COMT
35fluvoxamine43 49 129.2TPH1, HTR2A, HTR3A, SLC6A4, BDNF, MAOA
36quetiapine43 49 28 24 1211.1HTR2A, HTR1B, SLC6A3, SLC6A4, BDNF, DRD1
37imipramine43 28 49 24 1211.0SLC6A3, SLC6A4, BDNF, DRD1, DRD3, MAOA
38nicotine43 28 49 129.9SLC6A3, SLC6A4, DRD1, DRD3, DRD4, PDYN
39olanzapine43 49 28 24 1210.8SLC6A3, SLC6A4, BDNF, DRD1, DRD3, DRD4
405-hydroxytryptamine436.8MAOA, COMT, HTR1A, HTR3A, HTR1B, TPH1
41clozapine43 28 49 129.8HTR2A, HTR1B, SLC6A3, SLC6A4, BDNF, DRD1
42risperidone43 49 28 59 24 1211.7SLC6A3, SLC6A4, BDNF, DRD1, DRD3, DRD4
43methamphetamine43 49 128.7TPH1, COMT, SLC6A3, SLC6A4, BDNF, DRD1
44gaba436.7SLC6A3, SLC1A1, SLC6A4, BDNF, TPH1, PDYN
45nmda43 287.4SLC6A3, SLC1A1, SLC6A4, BDNF, DRD1, DRD3
46levodopa43 127.2PDYN, MAOA, COMT, HTR1A, HTR1B, TPH1
47glutamate436.1SLC6A3, TPH1, HTT, SLC1A1, SLC6A4, BDNF
48paroxetine43 49 28 129.1BDNF, DRD3, DRD4, MAOA, COMT, HTR1A
49norepinephrine43 24 127.5PDYN, MAOA, COMT, HTR1A, HTR3A, HTR2A
50dopamine43 28 24 128.0SLC6A3, SLC6A4, BDNF, DRD1, DRD3, TPH1

GO Terms for genes affiliated with Obsessive-Compulsive Disorder

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Cellular components related to Obsessive-Compulsive Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430258.6SLC6A3, DRD4, HTR3A, HTR2A
2axonGO:00304248.4HTR2A, HTR3A, HTT, SLC6A3
3integral component of plasma membraneGO:00058876.3DRD1, SLC1A1, SLC6A4, DRD3, DRD4, HTR1A
4plasma membraneGO:00058865.7SLC6A3, HTR2A, SLC1A1, SLC6A4, DRD1, DRD3

Biological processes related to Obsessive-Compulsive Disorder according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1L-glutamate importGO:005193810.3HTT, SLC1A1
2negative regulation of synaptic transmission, glutamatergicGO:005196710.3HTR2A, HTR1B
3dopamine receptor signaling pathwayGO:000721210.2HTT, DRD4
4regulation of hormone secretionGO:004688310.2HTR2A, HTR1A
5adenylate cyclase-inhibiting serotonin receptor signaling pathwayGO:000719810.2HTR1A, HTR1B
6negative regulation of cAMP biosynthetic processGO:003081810.2HTR1B, DRD4
7memoryGO:000761310.1HTR2A, DRD1, SLC6A4
8response to histamineGO:003477610.0DRD4, DRD3
9striatum developmentGO:002175610.0DRD1, HTT
10adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:000719510.0DRD3, DRD4
11regulation of behaviorGO:005079510.0HTR1A, HTR1B, HTR2A
12vasoconstrictionGO:004231010.0HTR1B, SLC6A4, HTR1A
13circadian rhythmGO:000762310.0SLC6A4, DRD4, TPH1
14regulation of dopamine uptake involved in synaptic transmissionGO:005158410.0DRD3, DRD1
15bone remodelingGO:00468499.9HTR1B, TPH1
16regulation of dopamine secretionGO:00140599.9HTR2A, DRD3, HTR1B
17grooming behaviorGO:00076259.9HTT, DRD1
18negative regulation of protein secretionGO:00507099.9DRD4, DRD3
19G-protein coupled receptor internalizationGO:00020319.9HTR1B, DRD3
20adenylate cyclase-activating dopamine receptor signaling pathwayGO:00071919.8DRD3, DRD1
21neurotransmitter catabolic processGO:00421359.8MAOA, COMT
22temperature homeostasisGO:00016599.8DRD1, HTR2A
23arachidonic acid secretionGO:00504829.8DRD4, DRD3
24cellular calcium ion homeostasisGO:00068749.8HTR2A, DRD4, DRD3
25monoamine transportGO:00158449.8SLC6A4, SLC6A3
26dopamine metabolic processGO:00424179.8DRD1, DRD3, DRD4
27synaptic transmission, dopaminergicGO:00019639.7DRD3, DRD1, DRD4
28visual learningGO:00085429.7DRD3, DRD1, HTT
29serotonin receptor signaling pathwayGO:00072109.7HTR2A, HTR3A, HTR1A
30response to amphetamineGO:00019759.7DRD4, DRD1, DRD3
31social behaviorGO:00351769.7HTT, DRD4, DRD3, SLC6A4
32behavioral fear responseGO:00016629.7DRD4, DRD1, BDNF, HTR1A
33dopamine transportGO:00158729.6SLC6A3, DRD1
34behavioral response to cocaineGO:00481489.6DRD3, HTR2A, DRD4, DRD1
35negative regulation of adenylate cyclase activityGO:00071949.4DRD3, DRD4
36prepulse inhibitionGO:00601349.2DRD1, DRD3, SLC6A3
37locomotory behaviorGO:00076269.2SLC6A3, DRD3, HTT
38dopamine catabolic processGO:00424209.1SLC6A3, MAOA, COMT
39neurotransmitter biosynthetic processGO:00421369.1COMT, SLC6A3, MAOA
40regulation of dopamine metabolic processGO:00420539.1DRD4, HTR1A, SLC6A3, DRD1
41cell deathGO:00082199.0SLC6A3, HTR2A, PDYN
42response to cocaineGO:00422208.8SLC6A3, HTR3A, HTR1B, DRD3
43response to ethanolGO:00454718.7SLC6A3, HTR1B, HTR3A, DRD3
44response to drugGO:00424938.5DRD1, SLC6A4, SLC6A3, HTR2A, COMT, DRD3
45synaptic transmissionGO:00072688.1SLC6A3, HTR3A, COMT, HTR2A, MAOA, SLC1A1

Molecular functions related to Obsessive-Compulsive Disorder according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:00049529.8DRD4, DRD1
2serotonin bindingGO:00513789.5HTR3A, HTR1B, HTR2A
3monoamine transmembrane transporter activityGO:00085049.4SLC6A4, SLC6A3
4dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00015919.4DRD4, DRD3
5serotonin receptor activityGO:00049939.2HTR2A, HTR1B, HTR3A, HTR1A
6dopamine bindingGO:00352408.7SLC6A3, DRD1, DRD3, DRD4
7drug bindingGO:00081448.5SLC6A3, DRD3, DRD4, HTR2A, HTR1B

Products for genes affiliated with Obsessive-Compulsive Disorder

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Sources for Obsessive-Compulsive Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet