MCID: OBS002
MIFTS: 73

Obsessive-Compulsive Disorder malady

Neuronal diseases category

Summaries for Obsessive-Compulsive Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Obsessive-compulsive disorder (ocd) is a type of anxiety disorder. if you have ocd, you have frequent, upsetting thoughts called obsessions. to try to control the thoughts, you feel an overwhelming urge to repeat certain rituals or behaviors. these are called compulsions. examples of obsessions are a fear of germs or a fear of being hurt. compulsions include washing your hands, counting, checking on things, or cleaning. with ocd, the thoughts and rituals cause distress and get in the way of your daily life. researchers think brain circuits may not work properly in people who have ocd. it tends to run in families. the symptoms often begin in children or teens. treatments include therapy, medicines, or both. one type of therapy, cognitive behavioral therapy, is useful for treating ocd. nih: national institute of mental health

MalaCards: Obsessive-Compulsive Disorder, also known as obsessive compulsive disorder, is related to obsessive-compulsive personality disorder and personality disorder. An important gene associated with Obsessive-Compulsive Disorder is OCD1 (obsessive-compulsive disorder 1), and among its related pathways are phenylalanine utilization and Enzymatic degradation of dopamine by COMT. The drugs citalopram and clomipramine and the compounds ketanserin and venlafaxine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and thalamus, and related mouse phenotypes are cardiovascular system and growth/size.

Disease Ontology:8 An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions).

Wikipedia:63 Obsessive–compulsive disorder (OCD) is an anxiety disorder characterized by intrusive thoughts that... more...

Description from OMIM:46 164230

Aliases & Classifications for Obsessive-Compulsive Disorder

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8Disease Ontology, 22GTR, 46OMIM, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

obsessive-compulsive disorder 8 46 44 33 60
obsessive compulsive disorder 8 22
anancastic neurosis 8


External Ids:

Disease Ontology8 DOID:10933
MeSH34 D009771
ICD9CM27 300.3
ICD1025 F42

Related Diseases for Obsessive-Compulsive Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Obsessive-Compulsive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1obsessive-compulsive personality disorder31.3SLC6A4
2personality disorder31.3TPH1, SLC6A4, SLC6A3, MAOA, DRD4, DRD3
3anxiety disorder31.3TPH1, TSPO, SLC6A4, SLC6A3, MAOA, HTR2A
4panic disorder31.2TSPO, HTR1A, SLC6A4, HTR3A
5schizophrenia31.2COMT, DRD3, HTR2A
6generalized anxiety disorder31.1SLC6A4, HTR1A, TSPO
7pathological gambling31.0DRD3, DRD1, DRD4, SLC6A3
8bipolar disorder31.0SLC6A4, HTR3A, HTR2A
9social phobia31.0COMT, SLC6A4, MAOA, HTR3A, HTR1A
10agoraphobia31.0MAOA, HTR1A
11gilles de la tourette syndrome30.9SLC6A3, DRD4
12eating disorder30.9SLC6A4
13anorexia nervosa30.9HTR2A, BDNF
14mood disorder30.8COMT, TPH1, SLC6A4, SLC6A3, MAOA, DRD4
15attention deficit hyperactivity disorder30.8SLC6A3, DRD4
16schizoaffective disorder30.6SLC6A4, DRD4, DRD3, HTR2A, BDNF, COMT
17multiple sclerosis30.6BDNF, COMT, TSPO
18myoclonus-dystonia30.5SGCE
19autistic disorder30.5DRD4, SLC6A4, BDNF
20seasonal affective disorder30.5TPH1, DRD4, HTR2A, HTR1A, SLC6A4
21alcohol dependence30.5HTR1B, HTR2A, DRD1, DRD4, MAOA, SLC6A4
22bulimia nervosa30.5SLC6A4, MAOA, HTR2A, HTR3A, HTR1B, BDNF
23psychotic disorder30.5HTR2A, HTR3A, HTR1A, PDYN, BDNF, COMT
24narcolepsy30.3DRD1, HTR2A, COMT
25paranoid schizophrenia30.3COMT
26drug dependence30.3SLC6A4, SLC6A3, MAOA, DRD3, PDYN
27temporal lobe epilepsy30.3HTR1A, PDYN, BDNF, TSPO, SLC1A1
28delusional disorder30.3DRD4
29parkinson's disease30.3COMT, BDNF, PDYN, HTR1A, DRD3, MAOA
30migraine30.3MAOA, TPH1, SLC6A4, DRD4, DRD3, DRD1
31pick's disease30.2HTT
32amyotrophic lateral sclerosis30.2TSPO, BDNF, HTT, SLC6A3
33dementia30.2COMT, BDNF, HTR1A, HTR3A, HTR2A, HTT
34alzheimer's disease30.2BDNF, COMT, MAOA, SLC6A4, DRD4, SLC6A3
35trichotillomania10.9
36body dysmorphic disorder10.9
37tic disorder10.8
38major depressive disorder10.7
39hypochondriasis10.7
40chronic tic disorder10.6
41neuronitis10.6
42schizotypal personality disorder10.6
43dissociative disorder10.6
44sexual disorder10.6
45alexithymia10.5
46sleep disorder10.5
47cerebritis10.5
48neuroacanthocytosis10.5
49asperger syndrome10.4
50obsessive-compulsive disorder, protection against10.4

Graphical network of the top 20 diseases related to Obsessive-Compulsive Disorder:



Diseases related to obsessive-compulsive disorder

Clinical Features for Obsessive-Compulsive Disorder

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46OMIM
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Clinical features from OMIM:

164230

Drugs & Therapeutics for Obsessive-Compulsive Disorder

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Obsessive-Compulsive Disorder

Drug clinical trials:

Search ClinicalTrials for Obsessive-Compulsive Disorder

Search NIH Clinical Center for Obsessive-Compulsive Disorder

Search CenterWatch for Obsessive-Compulsive Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Obsessive-Compulsive Disorder

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22GTR
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Genetic tests related to Obsessive-Compulsive Disorder:

id Genetic test Affiliating Genes
1 Obsessive-Compulsive Disorder22

Anatomical Context for Obsessive-Compulsive Disorder

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32MalaCards
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MalaCards organs/tissues related to Obsessive-Compulsive Disorder:

32
Brain, Cortex, Thalamus, Testes, Subthalamic nucleus, Pituitary, Skin, Prefrontal cortex, Cingulate cortex, Temporal lobe, Hypothalamus, Pineal, Amygdala, B cells, Eye, Pons

Animal Models for Obsessive-Compulsive Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Obsessive-Compulsive Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.2TPH1, HTR1B, HTR1A, HTT, DRD1, DRD3
2MP:000537810.2SLC6A3, DRD3, DRD1, HTT, HTR3A, HTR1B
3MP:000363110.2DRD1, DRD3, DRD4, MAOA, BDNF, HTT
4MP:000536910.1SGCE, HTR3A, HTR2A, DRD1, SLC6A3, SLC6A4
5MP:000538610.1TPH1, HTR1A, HTR3A, HTR2A, DRD3, HTT
6MP:000537610.1DRD1, HTT, HTR1A, PDYN, BDNF, DRD3
7MP:00107719.9HTT, PDYN, BDNF, HTR3A, DRD1, SLC6A3

Publications for Obsessive-Compulsive Disorder

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50PubMed
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Articles related to Obsessive-Compulsive Disorder:

(show top 50)    (show all 933)
idTitleAuthorsYear
1
Extraordinarily Fast Response to Low-Dose Sertraline in a Child with Severe Obsessive-Compulsive Disorder and High Functioning Serotonin Transporter Genotype. (24432825)
2014
2
A 5-year prospective follow-up study of patients with obsessive-compulsive disorder treated with serotonin reuptake inhibitors. (24157088)
2014
3
Incompleteness as a Link between Obsessive-Compulsive Personality Traits and Specific Symptom Dimensions of Obsessive-Compulsive Disorder. (23650140)
2013
4
A Preliminary Study on the Effects of Attachment-based Intervention on Pediatric Obsessive-Compulsive Disorder. (23413047)
2013
5
Psychometric properties of the obsessive compulsive inventory: child version in children and adolescents with obsessive-compulsive disorder. (22711294)
2013
6
A longitudinal VBM study in paediatric obsessive-compulsive disorder at 2-year follow-up after cognitive behavioural therapy. (24125065)
2013
7
Sexual obsessions in pediatric obsessive-compulsive disorder: clinical characteristics and treatment outcomes. (23532924)
2013
8
Pharmacotherapy response and regional cerebral blood flow characteristics in patients with obsessive-compulsive disorder. (23898909)
2013
9
Defining Clinical Severity in Pediatric Obsessive-Compulsive Disorder. (24320764)
2013
10
Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder. (23876376)
2013
11
No association between DRD4 gene and SRI treatment response in obsessive compulsive disorder: need for a novel approach. (23810146)
2013
12
Structural brain MR imaging changes associated with obsessive-compulsive disorder in patients with multiple sclerosis. (22821917)
2013
13
Increased error-related brain activity in youth with obsessive-compulsive disorder and other anxiety disorders. (23454285)
2013
14
Clinical predictors of long-term outcome in obsessive-compulsive disorder. (23109056)
2013
15
Antipsychotic augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a meta-analysis of double-blind, randomized, placebo-controlled trials. (22932229)
2013
16
BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder. (24050777)
2013
17
Cognitive-behavioral therapy for obsessive-compulsive disorder: a meta-analysis of treatment outcome and moderators. (22999486)
2013
18
Patient satisfaction with specialized mental health service for obsessive-compulsive disorder. (24341311)
2013
19
Rage takes center stage: focus on an underappreciated aspect of pediatric obsessive-compulsive disorder. (22632616)
2012
20
Comorbid bipolar affective disorder and obsessive compulsive disorder in childhood: a case study and brief review. (23440037)
2012
21
Successful treatment of co-occurring catatonia and obsessive-compulsive disorder with concurrent electroconvulsive therapy and benzodiazepine administration. (22914637)
2012
22
Reduction of N-acetylaspartate in the medial prefrontal cortex correlated with symptom severity in obsessive-compulsive disorder: meta-analyses of (1)H-MRS studies. (22892718)
2012
23
Do pathological gambling and obsessive-compulsive disorder overlap? a neurocognitive perspective. (22794118)
2012
24
Attribution retraining group therapy for outpatients with major depression disorder, generalized anxiety disorder, and obsessive-compulsive disorder: a pilot study. (23554710)
2011
25
Higher prevalence of obsessive-compulsive spectrum disorders in rheumatic fever. (19269540)
2009
26
The heterogeneous structure of schizotypal personality disorder: item-level factors of the Schizotypal Personality Questionnaire and their associations with obsessive-compulsive disorder symptoms, dissociative tendencies, and normal personality. (18489212)
2008
27
Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes. (19398820)
2008
28
Obsessive-compulsive disorder in youth with and without a chronic tic disorder. (17345600)
2008
29
Association study between the dopamine receptor D(4) gene and obsessive-compulsive disorder. (16996722)
2007
30
Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial. (17503984)
2007
31
Level of insight and clinical features of obsessive-compulsive disorder with and without body dysmorphic disorder. (17426667)
2007
32
The impact of obsessive-compulsive personality disorder on the suicidal risk of patients with mood disorders. (17337939)
2007
33
Brain-derived neurotrophic factor: a genetic risk factor for obsessive-compulsive disorder and Tourette syndrome? (16541456)
2006
34
Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. (16816237)
2006
35
SERT and DAT availabilities under citalopram treatment in obsessive-compulsive disorder (OCD). (16139170)
2005
36
Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity. (15893825)
2005
37
Longitudinal diagnostic efficiency of DSM-IV criteria for obsessive-compulsive personality disorder: a 2-year prospective study. (15180781)
2004
38
Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22. (15368493)
2004
39
Effects of CCK-tetrapeptide in patients with social phobia and obsessive-compulsive disorder. (15390214)
2004
40
Examination of the SGCE gene in Tourette syndrome patients with obsessive-compulsive disorder. (15368614)
2004
41
Lack of association of catechol-O-methyltransferase gene polymorphism in obsessive-compulsive disorder. (12900951)
2003
42
Disturbed monitoring and response inhibition in patients with Gilles de la Tourette syndrome and co-morbid obsessive compulsive disorder. (12719636)
2003
43
Personality dimensions in pathological gambling disorder and obsessive-compulsive disorder. (11728609)
2001
44
Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder. (10523819)
1999
45
Role of serotonin in obsessive-compulsive disorder. (9829022)
1998
46
Paroxetine in a patient with obsessive-compulsive disorder, anorexia nervosa and schizotypal personality disorder. (9595892)
1998
47
Changes in cerebrospinal fluid neurochemistry during treatment of obsessive-compulsive disorder with clomipramine. (7524463)
1994
48
Neuroendocrine responses to single doses of buspirone in obsessive-compulsive disorder. (8056999)
1994
49
DSM-III personality disorders in generalized anxiety, panic/agoraphobia, and obsessive-compulsive disorders. (8348802)
1993
50
Serotonin syndrome-like symptoms in a patient with obsessive-compulsive disorder, following inappropriate increase in fluvoxamine dosage. (8415895)
1993

Genetic Variations for Obsessive-Compulsive Disorder

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Expression for genes affiliated with Obsessive-Compulsive Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Obsessive-Compulsive Disorder

Search GEO for disease gene expression data for Obsessive-Compulsive Disorder.

Pathways for genes affiliated with Obsessive-Compulsive Disorder

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37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 4Cell Signaling Technology, 51QIAGEN, 29KEGG
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Pathways related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4MAOA, COMT
2
Hide members
10.4SLC6A3, MAOA
310.4DRD4, DRD3, HTR2A
410.4DRD1, DRD3, DRD4
5
Hide members
10.4DRD4, DRD3, DRD1
610.4HTR1A, HTT, SLC1A1, TPH1
7
Hide members
10.3COMT, MAOA, SLC6A3, SLC1A1
8
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10.3BDNF, DRD1, DRD3, DRD4
9
Hide members
10.3HTR2A, HTR3A, HTR1A, HTR1B, BDNF
1010.3BDNF, PDYN, DRD1, MAOA, SLC6A3
11
Hide members
10.3SLC6A3, MAOA, DRD1, PDYN, BDNF
1210.3BDNF, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
13
Hide members
10.2PDYN, HTR1B, HTR1A, HTR2A, DRD1, DRD3
14
Hide members
10.2SLC6A4, MAOA, DRD4, DRD3, DRD1, HTR2A
15
Hide members
10.1SLC1A1, COMT, HTR1B, SLC6A4, SLC6A3, MAOA

Compounds for genes affiliated with Obsessive-Compulsive Disorder

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28IUPHAR, 44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 318)
idCompoundScoreTop Affiliating Genes
1ketanserin28 4411.7SLC6A4, HTR2A, HTR3A, HTR1A, HTR1B, BDNF
2venlafaxine49 44 11 2413.7HTR2A, HTR3A, HTR1A, HTR1B, BDNF, SLC6A3
3cabergoline28 44 1112.7HTR1A, DRD4, DRD3, DRD1, HTR2A, COMT
4ropinirole44 1111.7COMT, DRD4, DRD3, DRD1, HTR2A, HTR1A
5pergolide28 44 1112.7DRD3, DRD1, HTR2A, HTR1A, HTR1B, COMT
6apomorphine44 28 1112.7HTR2A, HTR1A, HTR1B, COMT, DRD1, DRD3
7fluoxetine49 44 28 1113.6SLC6A4, SLC6A3, MAOA, HTR2A, HTR3A, HTR1A
8fluvoxamine44 49 1112.6HTR2A, HTR3A, HTR1A, BDNF, MAOA, SLC6A3
9citalopram49 44 11 2413.6BDNF, HTR1A, HTR3A, HTR2A, MAOA, SLC6A3
10bromocriptine28 44 1112.6COMT, SLC6A3, DRD4, DRD3, DRD1, HTR2A
11maoa4410.6TPH1, SLC6A4, SLC6A3, MAOA, DRD4, HTR2A
12clomipramine44 49 1112.6MAOA, SLC6A3, SLC6A4, TSPO, HTR2A, HTR3A
13pramipexole44 49 28 1113.6BDNF, COMT, HTR1B, HTR1A, SLC6A3, DRD4
14quetiapine44 49 28 11 2414.6DRD1, HTR2A, HTR3A, HTR1A, HTR1B, BDNF
156-hydroxydopamine4410.6PDYN, DRD1, DRD3, DRD4, MAOA, SLC6A3
16raclopride44 2811.6HTR2A, DRD3, DRD4, HTR1A, SLC6A3, DRD1
17haloperidol44 28 2 49 1114.6SLC6A3, DRD4, DRD3, DRD1, HTR2A, HTR3A
18methamphetamine44 49 1112.6DRD1, PDYN, BDNF, COMT, DRD3, DRD4
19aripiprazole28 49 44 11 2414.6HTR2A, DRD1, DRD3, HTR1A, HTR1B, HTR3A
20mptp4410.6COMT, BDNF, DRD1, DRD3, MAOA, SLC6A3
21spiperone28 4411.6DRD1, HTR2A, HTR3A, HTR1A, DRD3, DRD4
22risperidone28 44 49 59 11 2415.6DRD1, HTR2A, HTR3A, HTR1A, HTR1B, BDNF
23methylphenidate44 49 1112.6SLC6A3, SLC6A4, DRD4, DRD1, COMT, MAOA
24ziprasidone49 28 44 1113.6DRD3, DRD1, HTR2A, HTR3A, HTR1A, HTR1B
25olanzapine49 44 28 11 2414.6DRD1, HTR2A, HTR3A, HTR1A, HTR1B, BDNF
26clozapine44 28 49 1113.6SLC6A4, SLC6A3, DRD4, DRD3, DRD1, HTR2A
27paroxetine44 49 28 1113.6TPH1, SLC6A4, SLC6A3, MAOA, DRD4, DRD3
28imipramine44 49 28 11 2414.5SLC6A3, SLC6A4, MAOA, DRD3, BDNF, DRD1
29lisuride28 44 1112.5HTR2A, HTR1A, HTR1B, DRD4, DRD3, DRD1
30nmda44 2811.5COMT, TSPO, PDYN, HTR1A, HTT, MAOA
31fenfluramine28 44 1112.5SLC6A4, HTR1B, HTR2A, HTR3A, HTR1A, TPH1
32chlorpromazine44 28 49 1113.5HTR3A, DRD4, DRD3, DRD1, HTR2A, BDNF
335-hydroxytryptamine4410.5COMT, HTR1B, HTR1A, HTR3A, HTR2A, DRD4
34carbon-114410.5TSPO, MAOA, HTR1A, SLC6A4, SLC6A3
35cocaine44 1111.5COMT, BDNF, PDYN, HTR1B, DRD1, DRD3
36gaba4410.5MAOA, SLC6A3, SLC6A4, SLC1A1, TSPO, TPH1
37nicotine44 49 28 1113.5DRD1, DRD3, DRD4, MAOA, SLC6A3, SLC6A4
38catecholamine4410.5PDYN, MAOA, COMT, TPH1, BDNF, DRD4
39iloperidone49 44 28 1113.4DRD1, HTR1A, HTR3A, HTR2A, DRD3, DRD4
40levodopa44 1111.4COMT, BDNF, PDYN, HTR1B, HTR1A, DRD1
41amphetamine44 1111.4SLC6A4, TPH1, SLC6A3, PDYN, DRD1, MAOA
42quinpirole44 2811.4HTR2A, DRD4, DRD3, DRD1, PDYN, SLC6A3
43norepinephrine44 11 2412.4COMT, BDNF, PDYN, HTR1A, HTR3A, HTR2A
44(+)-butaclamol28 4411.4HTR1A, HTR2A, DRD1, DRD3, DRD4
45glutamate4410.4MAOA, DRD4, SLC6A3, TSPO, TPH1, SLC6A4
46dopamine44 28 11 2413.4PDYN, HTR1B, DRD1, HTT, HTR2A, HTR3A
47d amphetamine4410.3MAOA, SLC6A3, SLC6A4, TSPO, DRD1
48asenapine28 1111.3DRD1, HTR1B, HTR1A, DRD4, DRD3, HTR2A
49heroin44 49 1112.2SLC6A4, COMT, PDYN, DRD4, SLC6A3, DRD3
50mcpp4410.0HTR2A, HTR3A, HTR1A, SLC6A4, HTR1B

GO Terms for genes affiliated with Obsessive-Compulsive Disorder

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16Gene Ontology
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Cellular components related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:03042410.4SLC6A3, HTT, HTR2A, HTR3A
2integral to plasma membraneGO:00588710.0SGCE, HTR1B, HTR1A, HTR3A, HTR2A, DRD1
3plasma membraneGO:0058869.8HTR3A, HTR1A, HTR1B, PDYN, COMT, HTR2A

Biological processes related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1regulation of behaviorGO:05079510.8HTR1B, HTR1A, HTR2A
2serotonin receptor signaling pathwayGO:00721010.8HTR1A, HTR3A, HTR2A
3regulation of dopamine secretionGO:01405910.8HTR1B, HTR2A, DRD3
4adenylate cyclase-inhibiting serotonin receptor signaling pathwayGO:00719810.8HTR1A, HTR1B
5dopamine catabolic processGO:04242010.8COMT, MAOA, SLC6A3
6regulation of hormone secretionGO:04688310.8HTR1A, HTR2A
7vasoconstrictionGO:04231010.8HTR1B, HTR1A, SLC6A4
8social behaviorGO:03517610.8SLC6A4, DRD4, DRD3, HTT
9dopamine metabolic processGO:04241710.8DRD1, DRD3, DRD4
10behavioral fear responseGO:00166210.8DRD4, DRD1, HTR1A, BDNF
11regulation of dopamine metabolic processGO:04205310.8SLC6A3, DRD4, DRD1, HTR1A
12response to histamineGO:03477610.8DRD3, DRD4
13behavioral response to cocaineGO:04814810.8DRD1, DRD3, DRD4
14response to cocaineGO:04222010.8HTR1B, HTR3A, DRD3, SLC6A3
15synaptic transmission, dopaminergicGO:00196310.8DRD1, DRD3, DRD4
16L-glutamate importGO:05193810.8HTT, SLC1A1
17neurotransmitter biosynthetic processGO:04213610.8SLC6A3, MAOA, COMT
18prepulse inhibitionGO:06013410.7DRD1, DRD3, SLC6A3
19regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD1, DRD3
20memoryGO:00761310.7SLC6A4, DRD1, HTR2A
21response to amphetamineGO:00197510.7DRD4, DRD3, DRD1
22monoamine transportGO:01584410.7SLC6A4, SLC6A3
23visual learningGO:00854210.7DRD3, DRD1, HTT
24dopamine transportGO:01587210.7DRD1, SLC6A3
25adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.7DRD3, DRD4
26neurotransmitter catabolic processGO:04213510.7MAOA, COMT
27dopamine receptor signaling pathwayGO:00721210.7DRD4, HTT
28negative regulation of synaptic transmission, glutamatergicGO:05196710.7HTR2A, HTR1B
29response to drugGO:04249310.7COMT, HTR2A, DRD1, DRD3, SLC6A3, SLC6A4
30synaptic transmissionGO:00726810.7COMT, PDYN, HTR1B, HTR3A, HTR2A, MAOA
31locomotory behaviorGO:00762610.7HTT, DRD3, SLC6A3
32negative regulation of cAMP biosynthetic processGO:03081810.6HTR1B, DRD4
33cellular calcium ion homeostasisGO:00687410.6HTR2A, DRD3, DRD4
34striatum developmentGO:02175610.6HTT, DRD1
35response to ethanolGO:04547110.6SLC6A3, DRD3, HTR1B
36adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD1, DRD3
37G-protein coupled receptor internalizationGO:00203110.5DRD3, HTR1B
38negative regulation of protein secretionGO:05070910.5DRD4, DRD3
39temperature homeostasisGO:00165910.4DRD1, HTR2A
40agingGO:00756810.4HTR2A, TSPO
41bone remodelingGO:04684910.3TPH1, HTR1B
42arachidonic acid secretionGO:05048210.1DRD4, DRD3

Molecular functions related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.5SLC6A3, DRD4, DRD3, DRD1
2drug bindingGO:00814410.4HTR1B, HTR2A, DRD3, DRD4, SLC6A3
3serotonin receptor activityGO:00499310.4HTR1B, HTR1A, HTR3A, HTR2A
4monoamine transmembrane transporter activityGO:00850410.4SLC6A4, SLC6A3
5serotonin bindingGO:05137810.4HTR2A, HTR3A, HTR1B
6dopamine neurotransmitter receptor activityGO:00495210.3DRD1, DRD4
7dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.1DRD3, DRD4

Products for genes affiliated with Obsessive-Compulsive Disorder

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Sources for Obsessive-Compulsive Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet