MCID: OBS002
MIFTS: 72

Obsessive-Compulsive Disorder malady

Mental diseases, Neuronal diseases categories

Summaries for Obsessive-Compulsive Disorder

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9Disease Ontology, 35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Obsessive-compulsive disorder (ocd) is a type of anxiety disorder. if you have ocd, you have frequent, upsetting thoughts called obsessions. to try to control the thoughts, you feel an overwhelming urge to repeat certain rituals or behaviors. these are called compulsions. examples of obsessions are a fear of germs or a fear of being hurt. compulsions include washing your hands, counting, checking on things, or cleaning. with ocd, the thoughts and rituals cause distress and get in the way of your daily life. researchers think brain circuits may not work properly in people who have ocd. it tends to run in families. the symptoms often begin in children or teens. treatments include therapy, medicines, or both. one type of therapy, cognitive behavioral therapy, is useful for treating ocd. nih: national institute of mental health

MalaCards: Obsessive-Compulsive Disorder, also known as obsessive compulsive disorder, is related to schizophrenia and panic disorder. An important gene associated with Obsessive-Compulsive Disorder is SLC6A4 (solute carrier family 6 (neurotransmitter transporter), member 4), and among its related pathways are Hypothetical Network for Drug Addiction and Monoamine Transport. The drugs citalopram and citalopram hydrobromide and the compounds mhpg and methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are muscle and growth/size/body.

Disease Ontology:9 An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions).

Wikipedia:66 Obsessive?compulsive disorder (OCD) is an anxiety disorder characterized by intrusive thoughts that... more...

Description from OMIM:48 164230

Aliases & Classifications for Obsessive-Compulsive Disorder

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9Disease Ontology, 23GTR, 48OMIM, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Neuronal diseases


Aliases & Descriptions:

obsessive-compulsive disorder 9 48 46 35 63
obsessive compulsive disorder 9 23
anancastic neurosis 9


External Ids:

Disease Ontology9 DOID:10933
ICD9CM28 300.3
MeSH36 D009771
ICD1026 F42

Related Diseases for Obsessive-Compulsive Disorder

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18GeneCards, 19GeneDecks
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Diseases related to Obsessive-Compulsive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.4COMT, HTR2A
2panic disorder31.3HTR3A, HTR1A, SLC6A4
3personality disorder31.3HTR1B, TPH1, MAOA, DRD4, SLC6A4
4generalized anxiety disorder31.2SLC6A4, HTR1A
5pathological gambling31.2DRD4, DRD1
6gilles de la tourette syndrome31.1DRD4
7anorexia nervosa31.1HTR2A, BDNF
8agoraphobia31.1MAOA, HTR1A
9anxiety disorder31.0SLC6A4, BDNF, MAOA, HTR1A, HTR3A, HTR2A
10social phobia30.9HTR3A, MAOA, HTR1A, COMT, SLC6A4
11eating disorder30.9HTR2A, HTR3A, HTR1A, COMT, SLC6A4, BDNF
12bipolar disorder30.9HTR3A, SLC6A4, HTR2A
13schizoaffective disorder30.7HTR2A, COMT, DRD4, SLC6A4, BDNF
14attention deficit hyperactivity disorder30.7SLC6A4, BDNF, DRD1, DRD4, MAOA, COMT
15autistic disorder30.7SLC6A4, BDNF, DRD4
16seasonal affective disorder30.6HTR1A, SLC6A4, DRD4, HTR2A, TPH1
17memory impairment30.5PDYN, HTR1A, BDNF, DRD1, HTR2A
18paranoid schizophrenia30.5COMT
19alcohol dependence30.5SLC6A4, HTR2A, HTR1B, MAOA, DRD4, DRD1
20drug addiction30.4PDYN, BDNF, DRD1
21bulimia nervosa30.4MAOA, BDNF, SLC6A4, COMT, HTR3A, HTR1B
22mood disorder30.4TPH1, HTR2A, HTR1B, HTR3A, HTR1A, COMT
23temporal lobe epilepsy30.3BDNF, SLC1A1, HTR1A, PDYN
24drug dependence30.3MAOA, PDYN, SLC6A4
25serotonin syndrome30.2MAOA, HTR1A, HTR3A, HTR2A
26parkinson's disease30.2MAOA, COMT, HTR1A, BDNF, PDYN
27mental retardation30.2MAOA, TPH1, HTR3A, COMT, BDNF
28psychotic disorder30.1TPH1, HTR2A, HTR3A, HTR1A, COMT, MAOA
29dementia30.1COMT, HTR1A, MAOA, BDNF, HTT, HTR3A
30migraine30.0TPH1, HTR2A, HTR1B, HTR3A, HTR1A, COMT
31alzheimer's disease29.9TPH1, HTR2A, HTT, HTR1A, COMT, MAOA
32trichotillomania10.9
33body dysmorphic disorder10.9
34obsessive-compulsive personality disorder10.8
35hypochondriasis10.7
36tic disorder10.7
37blindness10.7
38neuronitis10.6
39chronic tic disorder10.6
40schizotypal personality disorder10.6
41alexithymia10.6
42dystonia10.6
43major depressive disorder10.5
44cerebritis10.5
45neuroacanthocytosis10.5
46asperger syndrome10.5
47multiple sclerosis10.5
48obsessive-compulsive disorder, protection against10.5
49scurvy10.4
50autism spectrum disorder10.4

Graphical network of the top 20 diseases related to Obsessive-Compulsive Disorder:



Diseases related to obsessive-compulsive disorder

Symptoms for Obsessive-Compulsive Disorder

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48OMIM
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Clinical features from OMIM:

164230

Drugs & Therapeutics for Obsessive-Compulsive Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Obsessive-Compulsive Disorder

Drug clinical trials:

Search ClinicalTrials for Obsessive-Compulsive Disorder

Search NIH Clinical Center for Obsessive-Compulsive Disorder

Search CenterWatch for Obsessive-Compulsive Disorder

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Obsessive-Compulsive Disorder

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23GTR
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Genetic tests related to Obsessive-Compulsive Disorder:

id Genetic test Affiliating Genes
1 Obsessive-Compulsive Disorder23

Anatomical Context for Obsessive-Compulsive Disorder

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34MalaCards
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MalaCards organs/tissues related to Obsessive-Compulsive Disorder:

34
Brain, Cortex, Testes, Subthalamic nucleus, Prefrontal cortex, Thalamus, Skin, Pituitary, Hypothalamus, Amygdala, Temporal lobe, Pineal, B cells, Cingulate cortex, Eye, Pons

Animal Models for Obsessive-Compulsive Disorder or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Obsessive-Compulsive Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.6SGCE, HTR2A, TPH1, HTR1B, HTR3A, DRD1
2MP:00053787.1DRD1, TPH1, HTR1B, HTR3A, HTT, SLC6A4
3MP:00107717.1SLC6A4, BDNF, DRD1, TPH1, HTR3A, HTT
4MP:00053857.1HTT, SLC6A4, SGCE, TPH1, HTR1B, HTR1A
5MP:00036315.6HTR3A, HTT, HTR1A, COMT, MAOA, PDYN
6MP:00053765.4HTR3A, TPH1, PDYN, SLC6A4, BDNF, HTT
7MP:00053864.7SLC1A1, HTR1B, HTR3A, HTT, HTR1A, COMT

Publications for Obsessive-Compulsive Disorder

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53PubMed
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Articles related to Obsessive-Compulsive Disorder:

(show top 50)    (show all 855)
idTitleAuthorsYear
1
L-3,4-Dihydroxy-6-[F-18]fluorophenylalanine positron emission tomography demonstrating dopaminergic system abnormality in the brains of obsessive-compulsive disorder patients. (24405478)
2014
2
Moral rigidity in obsessive-compulsive disorder: do abnormalities in inhibitory control, cognitive flexibility and disgust play a role? (24161700)
2014
3
Discontinuous patterns of brain activation in the psychotherapy process of obsessive-compulsive disorder: converging results from repeated FMRI and daily self-reports. (23977168)
2013
4
Clinical features of pure obsessive-compulsive disorder. (23746710)
2013
5
Incompleteness as a Link between Obsessive-Compulsive Personality Traits and Specific Symptom Dimensions of Obsessive-Compulsive Disorder. (23650140)
2013
6
Cognitive Behavioural Therapy for Obsessive-Compulsive Disorder with Comorbid Schizophrenia: A Case Report with Repetitive Measurements. (23899371)
2013
7
Buprenorphine augmentation in the treatment of refractory obsessive-compulsive disorder. (23983988)
2013
8
Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder. (23200527)
2013
9
Pediatric obsessive-compulsive disorder: a review for nursing professionals. (23607826)
2013
10
Obsessive-compulsive disorder and cingulotomy. (23746096)
2013
11
Default network connectivity as a vulnerability marker for obsessive compulsive disorder. (24001350)
2013
12
Cognitive deficits of executive functions and decision-making in obsessive-compulsive disorder. (23841985)
2013
13
Is there a Role for Immunological Mechanisms in Etiopathogenesis of Obsessive Compulsive Disorder? (23833334)
2013
14
Obsessive-compulsive disorder in dermatology. (24049965)
2013
15
Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights. (23326403)
2013
16
Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder. (23410525)
2013
17
Compensatory Frontoparietal Activity During Working Memory: An Endophenotype of Obsessive-Compulsive Disorder. (24365484)
2013
18
Abnormal processing of deontological guilt in obsessive-compulsive disorder. (23681167)
2013
19
Deep brain stimulation in the treatment of obsessive-compulsive disorder. (23044000)
2013
20
Dissociative symptoms and dissociative disorder comorbidity in patients with obsessive-compulsive disorder. (22425531)
2012
21
Cognitive-behavioral therapy for obsessive-compulsive disorder as a comorbidity with schizophrenia or schizoaffective disorder. (22123432)
2012
22
Early sleep psychiatric intervention for acute insomnia: implications from a case of obsessive-compulsive disorder. (22505865)
2012
23
Contextual and behavioral influences on uncertainty in obsessive-compulsive disorder. (23318087)
2012
24
Schizophrenia and obsessive-compulsive disorder: from comorbidity to schizo-obsessive disorder. (22622247)
2012
25
Rage takes center stage: focus on an underappreciated aspect of pediatric obsessive-compulsive disorder. (22632616)
2012
26
Living with parents with obsessive-compulsive disorder: children's lives and experiences. (22903894)
2012
27
Sexual obsessions, compulsions, suicidality and homicidality in an adolescent diagnosed with bipolar disorder not otherwise specified, obsessive-compulsive disorder, pervasive developmental disorder not otherwise specified, and mild mental retardation. (22612525)
2012
28
Quality of life in patients with obsessive compulsive disorder: A longitudinal study from India. (23051114)
2011
29
Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET study. (19660554)
2010
30
Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder. (20565924)
2010
31
Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder. (19578685)
2009
32
Clozapine in treatment-refractory obsessive-compulsive disorder with comorbid schizotypal personality disorder. (19398826)
2008
33
Screening of the epsilon sarcoglycan gene in Tourette syndrome and obsessive compulsive disorder. (18349702)
2008
34
Association study between the dopamine receptor D(4) gene and obsessive-compulsive disorder. (16996722)
2007
35
Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample. (18094849)
2007
36
Rare plus common SERT variants in obsessive-compulsive disorder. (17453059)
2007
37
Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. (15667435)
2005
38
Obsessive-compulsive disorder and body dysmorphic disorder: a comparison of clinical features. (15276662)
2004
39
Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. (15083261)
2004
40
Dopamine transporter density of basal ganglia assessed with [123I]IPT SPET in obsessive-compulsive disorder. (14513291)
2003
41
Obsessive compulsive disorder among idiopathic focal dystonia patients: an epidemiological and family study. (12208643)
2002
42
No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. (10088048)
1999
43
Serotonergic function in social phobia: comparison to normal control and obsessive-compulsive disorder subjects. (9704868)
1998
44
Magnetic resonance brain imaging in women with obsessive-compulsive disorder and trichotillomania. (9255863)
1997
45
Obsessive compulsive symptoms in Gilles de la Tourette syndrome and obsessive compulsive disorder: differences by diagnosis and family history. (9259380)
1997
46
Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. (9114031)
1997
47
DRD2, DRD3 and 5HT2A receptor genes polymorphisms in obsessive-compulsive disorder. (9154247)
1996
48
Fenfluramine stimulation of prolactin in obsessive-compulsive disorder. (1603884)
1992
49
Response of obsessive-compulsive disorder and trichotillomania to serotonin reuptake blockers. (1728180)
1992
50
Prolactin and cortisol responses to MK-212, a serotonin agonist, in obsessive-compulsive disorder. (2203327)
1990

Variations for Obsessive-Compulsive Disorder

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Expression for genes affiliated with Obsessive-Compulsive Disorder

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Obsessive-Compulsive Disorder

Search GEO for disease gene expression data for Obsessive-Compulsive Disorder.

Pathways for genes affiliated with Obsessive-Compulsive Disorder

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 5Cell Signaling Technology, 31KEGG, 54QIAGEN, 52PharmGKB
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Pathways related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8DRD1, DRD4
2
Show member pathways
Serotonin Transporter Activity39
9.7SLC6A4, MAOA
39.6MAOA, COMT
49.6MAOA, COMT
5
Show member pathways
9.6MAOA, COMT
69.6COMT, MAOA
7
Show member pathways
catecholamine biosynthesis39
9.1MAOA, COMT, TPH1
88.9SLC1A1, HTR1A, HTT, TPH1
9
Show member pathways
8.7HTR2A, HTR1B, HTR1A, DRD4, DRD1
10
Show member pathways
8.7MAOA, PDYN, DRD1, BDNF
11
Show member pathways
8.7MAOA, PDYN, DRD1, BDNF
12
Show member pathways
8.3HTR2A, HTR1B, HTR3A, HTR1A, BDNF
13
Show member pathways
8.1HTR2A, HTR1B, HTR1A, PDYN, DRD4, DRD1
14
Show member pathways
8.1HTR2A, HTR1B, HTR1A, PDYN, DRD4, DRD1
157.4TPH1, HTR2A, HTR3A, HTR1A, MAOA, BDNF
167.4TPH1, HTR2A, HTR1B, HTR3A, HTR1A, MAOA
17
Show member pathways
6.0SLC1A1, TPH1, HTR2A, HTR1B, SLC6A4, DRD1

Compounds for genes affiliated with Obsessive-Compulsive Disorder

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 3BitterDB, 62Tocris Bioscience
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Compounds related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 277)
idCompoundScoreTop Affiliating Genes
1mhpg469.0SLC6A4, DRD4, COMT, MAOA, BDNF
2methylphenidate46 52 1210.8DRD4, DRD1, SLC6A4, COMT, MAOA
3ropinirole46 129.8DRD1, DRD4, COMT, HTR1A, HTR1B, HTR2A
4mcpp468.7HTR1B, HTR1A, HTR2A, SLC6A4, HTR3A
5pergolide46 30 1210.7HTR1B, DRD1, DRD4, COMT, HTR1A, HTR2A
6lisuride46 30 1210.7HTR1B, HTR1A, DRD4, DRD1, HTR2A
7cabergoline46 30 1210.7DRD1, DRD4, COMT, HTR1A, HTR1B, HTR2A
8pindolol46 30 1210.7HTR3A, SLC6A4, HTR1A, HTR1B, HTR2A
9apomorphine30 46 1210.7HTR1A, HTR2A, HTR1B, DRD4, COMT, DRD1
10bromocriptine46 30 1210.6HTR2A, HTR1B, HTR1A, COMT, DRD4, DRD1
11homovanillic acid46 259.5BDNF, MAOA, COMT, TPH1, SLC6A4
12nefazodone46 52 1210.5HTR1A, HTR3A, HTR1B, SLC6A4, HTR2A
13pramipexole46 30 52 1211.5DRD1, DRD4, COMT, HTR1A, HTR1B, BDNF
14spiperone46 309.5DRD1, DRD4, HTR1A, HTR3A, HTR2A
155-hydroxytryptophan468.4HTR1A, HTR2A, TPH1, HTR3A, SLC6A4
16(tfmpp)468.3HTR2A, HTR3A, HTR1A, HTR1B
17fenfluramine46 30 1210.3TPH1, SLC6A4, HTR1A, HTR3A, HTR1B, HTR2A
18aripiprazole30 46 52 25 1212.3HTR2A, HTR1B, HTR3A, DRD4, DRD1, HTR1A
19cocaine46 129.3SLC6A4, DRD4, DRD1, BDNF, COMT, HTR1B
20ziprasidone30 52 46 1211.2HTR1A, HTR1B, HTR3A, DRD4, DRD1, HTR2A
21Serotonin258.2HTR1B, SLC6A4, MAOA, HTR3A, HTR1A, HTR2A
22methysergide46 30 1210.2MAOA, HTR1A, HTR3A, HTR1B, HTR2A
23chlorpromazine30 46 52 1211.2DRD4, HTR2A, HTR3A, HTR1A, DRD1, BDNF
24clomipramine46 52 1210.2SLC6A4, HTR1B, HTR3A, HTR1A, MAOA, HTR2A
25mianserin46 30 1210.2HTR1A, HTR3A, HTR2A, SLC6A4, MAOA
266-hydroxydopamine468.2MAOA, PDYN, DRD4, DRD1, BDNF, COMT
27venlafaxine46 52 25 1211.2HTR2A, BDNF, SLC6A4, COMT, HTR1A, HTR3A
28iloperidone52 46 30 1211.2DRD4, HTR1A, HTR3A, DRD1, HTR2A
29ketanserin46 309.1SLC6A4, BDNF, DRD1, HTR3A, HTR1B, HTR2A
30amphetamine46 52 1210.1DRD4, TPH1, PDYN, SLC6A4, DRD1, MAOA
31haloperidol46 52 30 3 1212.0DRD4, HTR1A, DRD1, BDNF, HTR3A, HTR2A
32imipramine46 30 52 25 1211.9SLC6A4, BDNF, HTR2A, HTR3A, HTR1A, MAOA
33catecholamine467.9MAOA, COMT, PDYN, DRD4, DRD1, BDNF
34citalopram46 52 25 1210.8TPH1, HTR2A, HTR3A, HTR1A, MAOA, BDNF
35quetiapine46 52 30 25 1211.8SLC6A4, HTR1B, HTR2A, HTR3A, HTR1A, BDNF
36maoa467.7COMT, HTR1A, HTR1B, HTR2A, TPH1, MAOA
37methamphetamine46 52 129.7TPH1, COMT, MAOA, PDYN, DRD4, DRD1
38fluoxetine46 52 30 1210.6HTR2A, TPH1, HTR1B, HTR3A, HTR1A, SLC6A4
39fluvoxamine46 52 129.5SLC6A4, BDNF, MAOA, COMT, HTR1A, HTR3A
40olanzapine46 52 30 25 1211.5SLC6A4, BDNF, DRD1, DRD4, COMT, HTR1A
41risperidone46 52 30 62 25 1212.5DRD4, COMT, HTR1A, HTR3A, HTR1B, HTR2A
42clozapine46 30 52 1210.5SLC6A4, BDNF, DRD1, DRD4, HTR2A, HTR1B
43nmda46 308.3SLC6A4, HTR1A, HTT, SLC1A1, BDNF, DRD1
445-hydroxytryptamine467.1TPH1, HTR2A, HTR1B, HTR3A, HTR1A, COMT
45levodopa46 128.1HTR1A, COMT, MAOA, PDYN, DRD4, DRD1
46glutamate467.0MAOA, PDYN, DRD4, BDNF, DRD1, COMT
47gaba466.9BDNF, SLC6A4, SLC1A1, DRD1, DRD4, TPH1
48paroxetine46 52 30 129.9HTR3A, HTR2A, TPH1, HTR1A, COMT, MAOA
49norepinephrine46 25 128.1HTR3A, HTR1A, COMT, MAOA, PDYN, DRD4
50dopamine46 30 25 128.6TPH1, HTR2A, DRD4, DRD1, BDNF, SLC6A4

GO Terms for genes affiliated with Obsessive-Compulsive Disorder

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Sources:
17Gene Ontology
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Cellular components related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.2HTT, HTR3A, HTR2A
2integral component of plasma membraneGO:0058876.9SLC6A4, DRD1, DRD4, HTR1A, HTR3A, HTR1B
3plasma membraneGO:0058866.0SLC1A1, HTR2A, SLC6A4, DRD1, DRD4, PDYN

Biological processes related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine secretionGO:01405910.2HTR2A, HTR1B
2L-glutamate importGO:05193810.2SLC1A1, HTT
3negative regulation of synaptic transmission, glutamatergicGO:05196710.2HTR1B, HTR2A
4dopamine receptor signaling pathwayGO:00721210.2HTT, DRD4
5negative regulation of cAMP biosynthetic processGO:03081810.1HTR1B, DRD4
6regulation of hormone secretionGO:04688310.1HTR1A, HTR2A
7social behaviorGO:03517610.0SLC6A4, DRD4, HTT
8adenylate cyclase-inhibiting serotonin receptor signaling pathwayGO:00719810.0HTR1B, HTR1A
9dopamine metabolic processGO:04241710.0DRD1, DRD4
10striatum developmentGO:02175610.0HTT, DRD1
11synaptic transmission, dopaminergicGO:0019639.9DRD4, DRD1
12memoryGO:0076139.9SLC6A4, DRD1, HTR2A
13dopamine catabolic processGO:0424209.9COMT, MAOA
14behavioral response to cocaineGO:0481489.9HTR2A, DRD4, DRD1
15bone remodelingGO:0468499.9TPH1, HTR1B
16neurotransmitter catabolic processGO:0421359.9MAOA, COMT
17grooming behaviorGO:0076259.9HTT, DRD1
18circadian rhythmGO:0076239.8TPH1, DRD4, SLC6A4
19temperature homeostasisGO:0016599.8DRD1, HTR2A
20protein import into nucleusGO:0066069.8DRD1, HTT
21vasoconstrictionGO:0423109.8SLC6A4, HTR1A, HTR1B
22regulation of behaviorGO:0507959.8HTR1A, HTR1B, HTR2A
23neurotransmitter biosynthetic processGO:0421369.7COMT, MAOA
24regulation of dopamine metabolic processGO:0420539.6HTR1A, DRD4, DRD1
25response to drugGO:0424939.5HTR2A, COMT, DRD1, SLC6A4
26response to amphetamineGO:0019759.5DRD1, DRD4
27behavioral fear responseGO:0016629.4HTR1A, DRD4, DRD1, BDNF
28response to cocaineGO:0422209.3HTR1B, HTR3A
29serotonin receptor signaling pathwayGO:0072109.3HTR1A, HTR3A, HTR2A
30synaptic transmissionGO:0072688.6SLC1A1, MAOA, COMT, HTR3A, HTR2A

Molecular functions related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:0352409.8DRD1, DRD4
2dopamine neurotransmitter receptor activityGO:0049529.7DRD1, DRD4
3drug bindingGO:0081449.4HTR2A, DRD4, HTR1B
4serotonin bindingGO:0513789.1HTR2A, HTR1B, HTR3A
5serotonin receptor activityGO:0049938.7HTR1A, HTR3A, HTR1B, HTR2A

Products for genes affiliated with Obsessive-Compulsive Disorder

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Sources for Obsessive-Compulsive Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet