MCID: OBS002
MIFTS: 73

Obsessive-Compulsive Disorder malady

Neuronal diseases category

Summaries for Obsessive-Compulsive Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Obsessive-compulsive disorder (ocd) is a type of anxiety disorder. if you have ocd, you have frequent, upsetting thoughts called obsessions. to try to control the thoughts, you feel an overwhelming urge to repeat certain rituals or behaviors. these are called compulsions. examples of obsessions are a fear of germs or a fear of being hurt. compulsions include washing your hands, counting, checking on things, or cleaning. with ocd, the thoughts and rituals cause distress and get in the way of your daily life. researchers think brain circuits may not work properly in people who have ocd. it tends to run in families. the symptoms often begin in children or teens. treatments include therapy, medicines, or both. one type of therapy, cognitive behavioral therapy, is useful for treating ocd. nih: national institute of mental health

MalaCards: Obsessive-Compulsive Disorder, also known as obsessive compulsive disorder, is related to obsessive-compulsive personality disorder and personality disorder. An important gene associated with Obsessive-Compulsive Disorder is OCD1 (obsessive-compulsive disorder 1), and among its related pathways are phenylalanine utilization and Enzymatic degradation of dopamine by COMT. The drugs citalopram and clomipramine and the compounds ketanserin and venlafaxine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and thalamus, and related mouse phenotypes are cardiovascular system and growth/size.

Disease Ontology:8 An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions).

Wikipedia:63 Obsessive–compulsive disorder (OCD) is an anxiety disorder characterized by intrusive thoughts that... more...

Description from OMIM:46 164230

Aliases & Classifications for Obsessive-Compulsive Disorder

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8Disease Ontology, 46OMIM, 44Novoseek, 33MedlinePlus, 60UMLS, 22GTR, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

obsessive-compulsive disorder 8 46 44 33 60
obsessive compulsive disorder 8 22
anancastic neurosis 8


External Ids:

Disease Ontology8 DOID:10933
MeSH34 D009771
ICD9CM27 300.3
ICD1025 F42

Related Diseases for Obsessive-Compulsive Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Obsessive-Compulsive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1obsessive-compulsive personality disorder31.3SLC6A4
2personality disorder31.3TPH1, SLC6A4, SLC6A3, MAOA, DRD4, DRD3
3anxiety disorder31.3TPH1, TSPO, SLC6A4, SLC6A3, MAOA, HTR2A
4panic disorder31.2TSPO, HTR1A, SLC6A4, HTR3A
5schizophrenia31.2COMT, DRD3, HTR2A
6generalized anxiety disorder31.1SLC6A4, HTR1A, TSPO
7pathological gambling31.0DRD3, DRD1, DRD4, SLC6A3
8bipolar disorder31.0SLC6A4, HTR3A, HTR2A
9social phobia31.0COMT, SLC6A4, MAOA, HTR3A, HTR1A
10agoraphobia31.0MAOA, HTR1A
11gilles de la tourette syndrome30.9SLC6A3, DRD4
12eating disorder30.9SLC6A4
13anorexia nervosa30.9HTR2A, BDNF
14mood disorder30.8COMT, TPH1, SLC6A4, SLC6A3, MAOA, DRD4
15attention deficit hyperactivity disorder30.8SLC6A3, DRD4
16schizoaffective disorder30.6SLC6A4, DRD4, DRD3, HTR2A, BDNF, COMT
17multiple sclerosis30.6BDNF, COMT, TSPO
18myoclonus-dystonia30.5SGCE
19autistic disorder30.5DRD4, SLC6A4, BDNF
20seasonal affective disorder30.5TPH1, DRD4, HTR2A, HTR1A, SLC6A4
21alcohol dependence30.5HTR1B, HTR2A, DRD1, DRD4, MAOA, SLC6A4
22bulimia nervosa30.5SLC6A4, MAOA, HTR2A, HTR3A, HTR1B, BDNF
23psychotic disorder30.5HTR2A, HTR3A, HTR1A, PDYN, BDNF, COMT
24narcolepsy30.3DRD1, HTR2A, COMT
25paranoid schizophrenia30.3COMT
26drug dependence30.3SLC6A4, SLC6A3, MAOA, DRD3, PDYN
27temporal lobe epilepsy30.3HTR1A, PDYN, BDNF, TSPO, SLC1A1
28delusional disorder30.3DRD4
29parkinson's disease30.3COMT, BDNF, PDYN, HTR1A, DRD3, MAOA
30migraine30.3MAOA, TPH1, SLC6A4, DRD4, DRD3, DRD1
31pick's disease30.2HTT
32amyotrophic lateral sclerosis30.2TSPO, BDNF, HTT, SLC6A3
33dementia30.2COMT, BDNF, HTR1A, HTR3A, HTR2A, HTT
34alzheimer's disease30.2BDNF, COMT, MAOA, SLC6A4, DRD4, SLC6A3
35trichotillomania10.9
36body dysmorphic disorder10.9
37tic disorder10.8
38major depressive disorder10.7
39hypochondriasis10.7
40chronic tic disorder10.6
41neuronitis10.6
42schizotypal personality disorder10.6
43dissociative disorder10.6
44sexual disorder10.6
45alexithymia10.5
46sleep disorder10.5
47cerebritis10.5
48neuroacanthocytosis10.5
49asperger syndrome10.4
50obsessive-compulsive disorder, protection against10.4

Graphical network of the top 20 diseases related to Obsessive-Compulsive Disorder:



Diseases related to obsessive-compulsive disorder

Clinical Features for Obsessive-Compulsive Disorder

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46OMIM
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Clinical features from OMIM:

164230

Drugs & Therapeutics for Obsessive-Compulsive Disorder

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Obsessive-Compulsive Disorder

Drug clinical trials:

Search ClinicalTrials for Obsessive-Compulsive Disorder

Search NIH Clinical Center for Obsessive-Compulsive Disorder

Search CenterWatch for Obsessive-Compulsive Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Obsessive-Compulsive Disorder

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22GTR
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Genetic tests related to Obsessive-Compulsive Disorder:

id Genetic test Affiliating Genes
1 Obsessive-Compulsive Disorder22

Anatomical Context for Obsessive-Compulsive Disorder

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32MalaCards
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MalaCards organs/tissues related to Obsessive-Compulsive Disorder:

32
Brain, Cortex, Thalamus, Testes, Pituitary, Prefrontal cortex, Subthalamic nucleus, Skin, Pons, Amygdala, Pineal, Hypothalamus, Temporal lobe, Cingulate cortex, B cells, Eye

Animal Models for Obsessive-Compulsive Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Obsessive-Compulsive Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.2COMT, HTR1B, HTR1A, HTT, DRD1, DRD3
2MP:000537810.2PDYN, HTR1B, HTR3A, HTT, DRD1, DRD3
3MP:000363110.2HTT, HTR3A, HTR1A, PDYN, BDNF, COMT
4MP:000536910.1HTR1B, HTR3A, HTR2A, DRD1, SLC6A3, SLC6A4
5MP:000538610.1TPH1, COMT, BDNF, PDYN, HTR1B, HTR1A
6MP:000537610.1HTT, HTR3A, HTR1A, PDYN, BDNF, COMT
7MP:00107719.9BDNF, PDYN, HTR3A, HTT, DRD1, SLC6A3

Publications for Obsessive-Compulsive Disorder

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50PubMed
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Articles related to Obsessive-Compulsive Disorder:

(show top 50)    (show all 933)
idTitleAuthorsYear
1
Adverse childhood experiences and gender influence treatment seeking behaviors in obsessive-compulsive disorder. (24262116)
2014
2
N2 AND P3 POTENTIALS IN EARLY-ONSET AND LATE-ONSET PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER. (24214334)
2013
3
Counterfactual Processing of Economic Action-Outcome Alternatives in Obsessive-Compulsive Disorder: Further Evidence of Impaired Goal-Directed Behavior. (23452663)
2013
4
Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association studies. (22665263)
2013
5
12-Week, Placebo-Controlled Trial of Add-on Riluzole in the Treatment of Childhood-Onset Obsessive-Compulsive Disorder. (24356715)
2013
6
Rates and correlates of nonadherence to treatment in obsessive-compulsive disorder. (23334678)
2013
7
Symptom dimensions in obsessive-compulsive disorder: phenomenology and treatment outcomes with exposure and ritual prevention. (23615340)
2013
8
Enhanced reward-facilitating effects of d-amphetamine in rats in the quinpirole model of obsessive-compulsive disorder. (23043789)
2013
9
Differential role of visuospatial working memory in the propensity toward uncertainty in patients with obsessive-compulsive disorder and in healthy subjects. (24176225)
2013
10
Symptom dimensions in obsessive-compulsive disorder: differences in distress, interference, appraisals and neutralizing strategies. (23792753)
2013
11
Obsessive-compulsive symptoms and obsessive-compulsive disorder in adolescents: a population-based study. (24165685)
2013
12
Deep brain stimulation for the treatment of severe, medically refractory obsessive-compulsive disorder. (24361021)
2013
13
Subjective uncertainty and limbic hyperactivation in obsessive-compulsive disorder. (22461182)
2013
14
Antipsychotic augmentation of selective serotonin reuptake inhibitors in resistant tic-related obsessive-compulsive disorder in children and adolescents: a naturalistic comparative study. (23664673)
2013
15
Effects of agomelatine in a murine model of obsessive-compulsive disorder: interaction with meta-chlorophenylpiperazine, bicuculline, and diazepam. (23768699)
2013
16
Reduced dorsolateral prefrontal cortical hemodynamic response in adult obsessive-compulsive disorder as measured by near-infrared spectroscopy during the verbal fluency task. (23874098)
2013
17
Maintenance therapy with electroconvulsive therapy in a patient with a codiagnosis of bipolar disorder and obsessive-compulsive disorder. (23519221)
2013
18
Combined bilateral anterior cingulotomy and ventral capsule/ventral striatum deep brain stimulation for refractory obsessive-compulsive disorder with major depression: do combined procedures have a long-term benefit? (23979095)
2013
19
COMT Val158Met polymorphism and executive functions in obsessive-compulsive disorder. (23774999)
2013
20
Early sleep psychiatric intervention for acute insomnia: implications from a case of obsessive-compulsive disorder. (22505865)
2012
21
Comparison of checking behavior in adults with or without checking symptom of obsessive-compulsive disorder using a novel computer-based measure. (22522062)
2012
22
Long-term follow-up of deep brain stimulation for refractory obsessive-compulsive disorder. (22784468)
2012
23
A 2012 evidence-based algorithm for the pharmacotherapy for obsessive-compulsive disorder. (22527872)
2012
24
Religiosity, magical ideation, and paranormal beliefs in anxiety disorders and obsessive-compulsive disorder: a cross-sectional study. (22986279)
2012
25
The associative and limbic thalamus in the pathophysiology of obsessive-compulsive disorder: an experimental study in the monkey. (23010765)
2012
26
Granisetron adjunct to fluvoxamine for moderate to severe obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled trial. (22873680)
2012
27
An explorative study on metacognition in obsessive-compulsive disorder and panic disorder. (22018834)
2012
28
Olanzapine induced de-novo obsessive compulsive disorder in a patient with schizophrenia. (23112432)
2012
29
Error-related negativity and tic history in pediatric obsessive-compulsive disorder. (22917203)
2012
30
Using direct-to-consumer marketing strategies with obsessive-compulsive disorder in the nonprofit sector. (22440063)
2012
31
Impact of depressive and anxiety disorder comorbidity on the clinical expression of obsessive-compulsive disorder. (22136738)
2012
32
Association analysis of serotonin and catecholamine system candidate genes in obsessive-compulsive disorder in the Chinese population. (20937529)
2011
33
Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET study. (19660554)
2010
34
The role of the COMT Val(158)Met polymorphism in the phenotypic expression of obsessive-compulsive disorder. (19521967)
2010
35
The GABA(A)-receptor I^2 (GABRG2) gene in obsessive-compulsive disorder. (20098824)
2009
36
Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system. (18446263)
2008
37
Dopamine transporter density in the basal ganglia in obsessive-compulsive disorder, measured with [123I]IPT SPECT before and after treatment with serotonin reuptake inhibitors. (17657168)
2007
38
The relationship of body dysmorphic disorder and eating disorders to obsessive-compulsive disorder. (17514080)
2007
39
A prospective long-term follow-up study of alexithymia in obsessive-compulsive disorder. (16905403)
2006
40
Updated overview of the putative role of the serotoninergic system in obsessive-compulsive disorder. (18568072)
2005
41
T102C and -1438 G/A polymorphisms of the 5-HT2A receptor gene in Turkish patients with obsessive-compulsive disorder. (12927326)
2003
42
CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. (12809671)
2003
43
Normal pressure hydrocephalus manifesting as an obsessive-compulsive disorder responding to CSF drainage. (12814117)
2003
44
Association between the COMT locus and obsessive-compulsive disorder in females but not males. (11840516)
2002
45
5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study. (12192628)
2002
46
Quantitative and qualitative aspects of obsessive-compulsive behaviour in children with attention-deficit hyperactivity disorder compared with tic disorder. (10823299)
2000
47
Treatment of severe, drug resistant obsessive compulsive disorder with the 5HT1D agonist sumatriptan. (9928925)
1998
48
Depressive and obsessive-compulsive symptoms in hyperserotonemic parents of children with autistic disorder. (8047619)
1994
49
Circadian rhythms of melatonin, cortisol and prolactin in patients with obsessive-compulsive disorder. (8085472)
1994
50
Plasma tryptophan levels and plasma tryptophan/neutral amino acids ratio in patients with mood disorder, patients with obsessive-compulsive disorder, and normal subjects. (1480681)
1992

Genetic Variations for Obsessive-Compulsive Disorder

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Expression for genes affiliated with Obsessive-Compulsive Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Obsessive-Compulsive Disorder

Search GEO for disease gene expression data for Obsessive-Compulsive Disorder.

Pathways for genes affiliated with Obsessive-Compulsive Disorder

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37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 4Cell Signaling Technology, 51QIAGEN, 29KEGG
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Pathways related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4MAOA, COMT
2
Hide members
10.4SLC6A3, MAOA
310.4DRD4, DRD3, HTR2A
410.4DRD1, DRD3, DRD4
5
Hide members
10.4DRD4, DRD3, DRD1
610.4HTR1A, HTT, SLC1A1, TPH1
7
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10.3COMT, MAOA, SLC6A3, SLC1A1
8
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10.3BDNF, DRD1, DRD3, DRD4
9
Hide members
10.3HTR2A, HTR3A, HTR1A, HTR1B, BDNF
1010.3BDNF, PDYN, DRD1, MAOA, SLC6A3
11
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10.3SLC6A3, MAOA, DRD1, PDYN, BDNF
1210.3BDNF, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
13
Hide members
10.2PDYN, HTR1B, HTR1A, HTR2A, DRD1, DRD3
14
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10.2SLC6A4, MAOA, DRD4, DRD3, DRD1, HTR2A
15
Hide members
10.1SLC1A1, COMT, HTR1B, SLC6A4, SLC6A3, MAOA

Compounds for genes affiliated with Obsessive-Compulsive Disorder

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Sources:
28IUPHAR, 44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 318)
idCompoundScoreTop Affiliating Genes
1ketanserin28 4411.7SLC6A4, HTR2A, HTR3A, HTR1A, HTR1B, BDNF
2venlafaxine49 44 11 2413.7HTR2A, HTR3A, HTR1A, HTR1B, BDNF, SLC6A3
3cabergoline28 44 1112.7HTR1A, DRD4, DRD3, DRD1, HTR2A, COMT
4ropinirole44 1111.7COMT, DRD4, DRD3, DRD1, HTR2A, HTR1A
5pergolide28 44 1112.7DRD3, DRD1, HTR2A, HTR1A, HTR1B, COMT
6apomorphine44 28 1112.7HTR2A, HTR1A, HTR1B, COMT, DRD1, DRD3
7fluoxetine49 44 28 1113.6SLC6A4, SLC6A3, MAOA, HTR2A, HTR3A, HTR1A
8fluvoxamine44 49 1112.6HTR2A, HTR3A, HTR1A, BDNF, MAOA, SLC6A3
9citalopram49 44 11 2413.6BDNF, HTR1A, HTR3A, HTR2A, MAOA, SLC6A3
10bromocriptine28 44 1112.6COMT, SLC6A3, DRD4, DRD3, DRD1, HTR2A
11maoa4410.6TPH1, SLC6A4, SLC6A3, MAOA, DRD4, HTR2A
12clomipramine44 49 1112.6MAOA, SLC6A3, SLC6A4, TSPO, HTR2A, HTR3A
13pramipexole44 49 28 1113.6BDNF, COMT, HTR1B, HTR1A, SLC6A3, DRD4
14quetiapine44 49 28 11 2414.6DRD1, HTR2A, HTR3A, HTR1A, HTR1B, BDNF
156-hydroxydopamine4410.6PDYN, DRD1, DRD3, DRD4, MAOA, SLC6A3
16raclopride44 2811.6HTR2A, DRD3, DRD4, HTR1A, SLC6A3, DRD1
17haloperidol44 28 2 49 1114.6SLC6A3, DRD4, DRD3, DRD1, HTR2A, HTR3A
18methamphetamine44 49 1112.6DRD1, PDYN, BDNF, COMT, DRD3, DRD4
19aripiprazole28 49 44 11 2414.6HTR2A, DRD1, DRD3, HTR1A, HTR1B, HTR3A
20mptp4410.6COMT, BDNF, DRD1, DRD3, MAOA, SLC6A3
21spiperone28 4411.6DRD1, HTR2A, HTR3A, HTR1A, DRD3, DRD4
22risperidone28 44 49 59 11 2415.6DRD1, HTR2A, HTR3A, HTR1A, HTR1B, BDNF
23methylphenidate44 49 1112.6SLC6A3, SLC6A4, DRD4, DRD1, COMT, MAOA
24ziprasidone49 28 44 1113.6DRD3, DRD1, HTR2A, HTR3A, HTR1A, HTR1B
25olanzapine49 44 28 11 2414.6DRD1, HTR2A, HTR3A, HTR1A, HTR1B, BDNF
26clozapine44 28 49 1113.6SLC6A4, SLC6A3, DRD4, DRD3, DRD1, HTR2A
27paroxetine44 49 28 1113.6TPH1, SLC6A4, SLC6A3, MAOA, DRD4, DRD3
28imipramine44 49 28 11 2414.5SLC6A3, SLC6A4, MAOA, DRD3, BDNF, DRD1
29lisuride28 44 1112.5HTR2A, HTR1A, HTR1B, DRD4, DRD3, DRD1
30nmda44 2811.5COMT, TSPO, PDYN, HTR1A, HTT, MAOA
31fenfluramine28 44 1112.5SLC6A4, HTR1B, HTR2A, HTR3A, HTR1A, TPH1
32chlorpromazine44 28 49 1113.5HTR3A, DRD4, DRD3, DRD1, HTR2A, BDNF
335-hydroxytryptamine4410.5COMT, HTR1B, HTR1A, HTR3A, HTR2A, DRD4
34carbon-114410.5TSPO, MAOA, HTR1A, SLC6A4, SLC6A3
35cocaine44 1111.5COMT, BDNF, PDYN, HTR1B, DRD1, DRD3
36gaba4410.5MAOA, SLC6A3, SLC6A4, SLC1A1, TSPO, TPH1
37nicotine44 49 28 1113.5DRD1, DRD3, DRD4, MAOA, SLC6A3, SLC6A4
38catecholamine4410.5PDYN, MAOA, COMT, TPH1, BDNF, DRD4
39iloperidone49 44 28 1113.4DRD1, HTR1A, HTR3A, HTR2A, DRD3, DRD4
40levodopa44 1111.4COMT, BDNF, PDYN, HTR1B, HTR1A, DRD1
41amphetamine44 1111.4SLC6A4, TPH1, SLC6A3, PDYN, DRD1, MAOA
42quinpirole44 2811.4HTR2A, DRD4, DRD3, DRD1, PDYN, SLC6A3
43norepinephrine44 11 2412.4COMT, BDNF, PDYN, HTR1A, HTR3A, HTR2A
44(+)-butaclamol28 4411.4HTR1A, HTR2A, DRD1, DRD3, DRD4
45glutamate4410.4MAOA, DRD4, SLC6A3, TSPO, TPH1, SLC6A4
46dopamine44 28 11 2413.4PDYN, HTR1B, DRD1, HTT, HTR2A, HTR3A
47d amphetamine4410.3MAOA, SLC6A3, SLC6A4, TSPO, DRD1
48asenapine28 1111.3DRD1, HTR1B, HTR1A, DRD4, DRD3, HTR2A
49heroin44 49 1112.2SLC6A4, COMT, PDYN, DRD4, SLC6A3, DRD3
50mcpp4410.0HTR2A, HTR3A, HTR1A, SLC6A4, HTR1B

GO Terms for genes affiliated with Obsessive-Compulsive Disorder

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16Gene Ontology
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Cellular components related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:03042410.4SLC6A3, HTT, HTR2A, HTR3A
2integral to plasma membraneGO:00588710.0SGCE, HTR1B, HTR1A, HTR3A, HTR2A, DRD1
3plasma membraneGO:0058869.8HTR3A, HTR1A, HTR1B, PDYN, COMT, HTR2A

Biological processes related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1regulation of behaviorGO:05079510.8HTR1B, HTR1A, HTR2A
2serotonin receptor signaling pathwayGO:00721010.8HTR1A, HTR3A, HTR2A
3regulation of dopamine secretionGO:01405910.8HTR1B, HTR2A, DRD3
4adenylate cyclase-inhibiting serotonin receptor signaling pathwayGO:00719810.8HTR1A, HTR1B
5dopamine catabolic processGO:04242010.8COMT, MAOA, SLC6A3
6regulation of hormone secretionGO:04688310.8HTR1A, HTR2A
7vasoconstrictionGO:04231010.8HTR1B, HTR1A, SLC6A4
8social behaviorGO:03517610.8SLC6A4, DRD4, DRD3, HTT
9dopamine metabolic processGO:04241710.8DRD1, DRD3, DRD4
10behavioral fear responseGO:00166210.8DRD4, DRD1, HTR1A, BDNF
11regulation of dopamine metabolic processGO:04205310.8SLC6A3, DRD4, DRD1, HTR1A
12response to histamineGO:03477610.8DRD3, DRD4
13behavioral response to cocaineGO:04814810.8DRD1, DRD3, DRD4
14response to cocaineGO:04222010.8HTR1B, HTR3A, DRD3, SLC6A3
15synaptic transmission, dopaminergicGO:00196310.8DRD1, DRD3, DRD4
16L-glutamate importGO:05193810.8HTT, SLC1A1
17neurotransmitter biosynthetic processGO:04213610.8SLC6A3, MAOA, COMT
18prepulse inhibitionGO:06013410.7DRD1, DRD3, SLC6A3
19regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD1, DRD3
20memoryGO:00761310.7SLC6A4, DRD1, HTR2A
21response to amphetamineGO:00197510.7DRD4, DRD3, DRD1
22monoamine transportGO:01584410.7SLC6A4, SLC6A3
23visual learningGO:00854210.7DRD3, DRD1, HTT
24dopamine transportGO:01587210.7DRD1, SLC6A3
25adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.7DRD3, DRD4
26neurotransmitter catabolic processGO:04213510.7MAOA, COMT
27dopamine receptor signaling pathwayGO:00721210.7DRD4, HTT
28negative regulation of synaptic transmission, glutamatergicGO:05196710.7HTR2A, HTR1B
29response to drugGO:04249310.7COMT, HTR2A, DRD1, DRD3, SLC6A3, SLC6A4
30synaptic transmissionGO:00726810.7COMT, PDYN, HTR1B, HTR3A, HTR2A, MAOA
31locomotory behaviorGO:00762610.7HTT, DRD3, SLC6A3
32negative regulation of cAMP biosynthetic processGO:03081810.6HTR1B, DRD4
33cellular calcium ion homeostasisGO:00687410.6HTR2A, DRD3, DRD4
34striatum developmentGO:02175610.6HTT, DRD1
35response to ethanolGO:04547110.6SLC6A3, DRD3, HTR1B
36adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD1, DRD3
37G-protein coupled receptor internalizationGO:00203110.5DRD3, HTR1B
38negative regulation of protein secretionGO:05070910.5DRD4, DRD3
39temperature homeostasisGO:00165910.4DRD1, HTR2A
40agingGO:00756810.4HTR2A, TSPO
41bone remodelingGO:04684910.3TPH1, HTR1B
42arachidonic acid secretionGO:05048210.1DRD4, DRD3

Molecular functions related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.5SLC6A3, DRD4, DRD3, DRD1
2drug bindingGO:00814410.4HTR1B, HTR2A, DRD3, DRD4, SLC6A3
3serotonin receptor activityGO:00499310.4HTR1B, HTR1A, HTR3A, HTR2A
4monoamine transmembrane transporter activityGO:00850410.4SLC6A4, SLC6A3
5serotonin bindingGO:05137810.4HTR2A, HTR3A, HTR1B
6dopamine neurotransmitter receptor activityGO:00495210.3DRD1, DRD4
7dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.1DRD3, DRD4

Products for genes affiliated with Obsessive-Compulsive Disorder

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Sources for Obsessive-Compulsive Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet