MCID: OBS002
MIFTS: 72

Obsessive-Compulsive Disorder malady

Mental diseases, Neuronal diseases categories
Download this MalaCard

Summaries for Obsessive-Compulsive Disorder

About this section
Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard
MedlinePlus:34 Obsessive-compulsive disorder (ocd) is a type of anxiety disorder. if you have ocd, you have frequent, upsetting thoughts called obsessions. to try to control the thoughts, you feel an overwhelming urge to repeat certain rituals or behaviors. these are called compulsions. examples of obsessions are a fear of germs or a fear of being hurt. compulsions include washing your hands, counting, checking on things, or cleaning. with ocd, the thoughts and rituals cause distress and get in the way of your daily life. researchers think brain circuits may not work properly in people who have ocd. it tends to run in families. the symptoms often begin in children or teens. treatments include therapy, medicines, or both. one type of therapy, cognitive behavioral therapy, is useful for treating ocd. nih: national institute of mental health

MalaCards: Obsessive-Compulsive Disorder, also known as obsessive compulsive disorder, is related to schizophrenia and panic disorder. An important gene associated with Obsessive-Compulsive Disorder is SLC6A4 (solute carrier family 6 (neurotransmitter transporter), member 4), and among its related pathways are Hypothetical Network for Drug Addiction and Monoamine Transport. The drugs citalopram and citalopram hydrobromide and the compounds mhpg and methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are muscle and growth/size/body.

Disease Ontology:8 An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions).

Wikipedia:65 Obsessive?compulsive disorder (OCD) is an anxiety disorder characterized by intrusive thoughts that... more...

Description from OMIM:47 164230

Aliases & Classifications for Obsessive-Compulsive Disorder

About this section
Sources:
8Disease Ontology, 22GTR, 47OMIM, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Neuronal diseases


Aliases & Descriptions:

obsessive-compulsive disorder 8 47 45 34 62
obsessive compulsive disorder 8 22
anancastic neurosis 8


External Ids:

Disease Ontology8 DOID:10933
ICD9CM27 300.3
MeSH35 D009771
ICD1025 F42

Related Diseases for Obsessive-Compulsive Disorder

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Obsessive-Compulsive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia31.4COMT, HTR2A
2panic disorder31.3HTR3A, HTR1A, SLC6A4
3personality disorder31.3HTR1B, TPH1, MAOA, DRD4, SLC6A4
4generalized anxiety disorder31.2SLC6A4, HTR1A
5pathological gambling31.2DRD4, DRD1
6gilles de la tourette syndrome31.1DRD4
7anorexia nervosa31.1HTR2A, BDNF
8agoraphobia31.1MAOA, HTR1A
9anxiety disorder31.0SLC6A4, BDNF, MAOA, HTR1A, HTR3A, HTR2A
10social phobia30.9HTR3A, MAOA, HTR1A, COMT, SLC6A4
11eating disorder30.9HTR2A, HTR3A, HTR1A, COMT, SLC6A4, BDNF
12bipolar disorder30.9HTR3A, SLC6A4, HTR2A
13schizoaffective disorder30.7HTR2A, COMT, DRD4, SLC6A4, BDNF
14attention deficit hyperactivity disorder30.7SLC6A4, BDNF, DRD1, DRD4, MAOA, COMT
15autistic disorder30.7SLC6A4, BDNF, DRD4
16seasonal affective disorder30.6HTR1A, SLC6A4, DRD4, HTR2A, TPH1
17memory impairment30.5PDYN, HTR1A, BDNF, DRD1, HTR2A
18paranoid schizophrenia30.5COMT
19alcohol dependence30.5SLC6A4, HTR2A, HTR1B, MAOA, DRD4, DRD1
20drug addiction30.4PDYN, BDNF, DRD1
21bulimia nervosa30.4MAOA, BDNF, SLC6A4, COMT, HTR3A, HTR1B
22mood disorder30.4TPH1, HTR2A, HTR1B, HTR3A, HTR1A, COMT
23temporal lobe epilepsy30.3BDNF, SLC1A1, HTR1A, PDYN
24drug dependence30.3MAOA, PDYN, SLC6A4
25serotonin syndrome30.2MAOA, HTR1A, HTR3A, HTR2A
26parkinson's disease30.2MAOA, COMT, HTR1A, BDNF, PDYN
27mental retardation30.2MAOA, TPH1, HTR3A, COMT, BDNF
28psychotic disorder30.1TPH1, HTR2A, HTR3A, HTR1A, COMT, MAOA
29dementia30.1COMT, HTR1A, MAOA, BDNF, HTT, HTR3A
30migraine30.0TPH1, HTR2A, HTR1B, HTR3A, HTR1A, COMT
31alzheimer's disease29.9TPH1, HTR2A, HTT, HTR1A, COMT, MAOA
32trichotillomania10.9
33body dysmorphic disorder10.9
34obsessive-compulsive personality disorder10.8
35hypochondriasis10.7
36tic disorder10.7
37blindness10.7
38neuronitis10.6
39chronic tic disorder10.6
40schizotypal personality disorder10.6
41alexithymia10.6
42dystonia10.6
43major depressive disorder10.5
44cerebritis10.5
45neuroacanthocytosis10.5
46asperger syndrome10.5
47multiple sclerosis10.5
48obsessive-compulsive disorder, protection against10.5
49scurvy10.4
50autism spectrum disorder10.4

Graphical network of the top 20 diseases related to Obsessive-Compulsive Disorder:



Diseases related to obsessive-compulsive disorder

Symptoms for Obsessive-Compulsive Disorder

About this section
Sources:
47OMIM
See all sources


Clinical features from OMIM:

164230

Drugs & Therapeutics for Obsessive-Compulsive Disorder

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Genetic Tests for Obsessive-Compulsive Disorder

About this section
Sources:
22GTR
See all sources

Genetic tests related to Obsessive-Compulsive Disorder:

id Genetic test Affiliating Genes
1 Obsessive-Compulsive Disorder22

Anatomical Context for Obsessive-Compulsive Disorder

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Obsessive-Compulsive Disorder:

33
Brain, Cortex, Testes, Subthalamic nucleus, Prefrontal cortex, Thalamus, Skin, Pituitary, Hypothalamus, Amygdala, Temporal lobe, Pineal, B cells, Cingulate cortex, Eye, Pons

Animal Models for Obsessive-Compulsive Disorder or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Obsessive-Compulsive Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.6SGCE, HTR2A, TPH1, HTR1B, HTR3A, DRD1
2MP:00053787.1DRD1, TPH1, HTR1B, HTR3A, HTT, SLC6A4
3MP:00107717.1SLC6A4, BDNF, DRD1, TPH1, HTR3A, HTT
4MP:00053857.1HTT, SLC6A4, SGCE, TPH1, HTR1B, HTR1A
5MP:00036315.6HTR3A, HTT, HTR1A, COMT, MAOA, PDYN
6MP:00053765.4HTR3A, TPH1, PDYN, SLC6A4, BDNF, HTT
7MP:00053864.7SLC1A1, HTR1B, HTR3A, HTT, HTR1A, COMT

Publications for Obsessive-Compulsive Disorder

About this section
Sources:
52PubMed
See all sources

Articles related to Obsessive-Compulsive Disorder:

(show top 50)    (show all 855)
idTitleAuthorsYear
1
L-3,4-Dihydroxy-6-[F-18]fluorophenylalanine positron emission tomography demonstrating dopaminergic system abnormality in the brains of obsessive-compulsive disorder patients. (24405478)
2014
2
Moral rigidity in obsessive-compulsive disorder: do abnormalities in inhibitory control, cognitive flexibility and disgust play a role? (24161700)
2014
3
Discontinuous patterns of brain activation in the psychotherapy process of obsessive-compulsive disorder: converging results from repeated FMRI and daily self-reports. (23977168)
2013
4
Clinical features of pure obsessive-compulsive disorder. (23746710)
2013
5
Incompleteness as a Link between Obsessive-Compulsive Personality Traits and Specific Symptom Dimensions of Obsessive-Compulsive Disorder. (23650140)
2013
6
Cognitive Behavioural Therapy for Obsessive-Compulsive Disorder with Comorbid Schizophrenia: A Case Report with Repetitive Measurements. (23899371)
2013
7
Buprenorphine augmentation in the treatment of refractory obsessive-compulsive disorder. (23983988)
2013
8
Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder. (23200527)
2013
9
Pediatric obsessive-compulsive disorder: a review for nursing professionals. (23607826)
2013
10
Obsessive-compulsive disorder and cingulotomy. (23746096)
2013
11
Default network connectivity as a vulnerability marker for obsessive compulsive disorder. (24001350)
2013
12
Cognitive deficits of executive functions and decision-making in obsessive-compulsive disorder. (23841985)
2013
13
Is there a Role for Immunological Mechanisms in Etiopathogenesis of Obsessive Compulsive Disorder? (23833334)
2013
14
Obsessive-compulsive disorder in dermatology. (24049965)
2013
15
Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights. (23326403)
2013
16
Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder. (23410525)
2013
17
Compensatory Frontoparietal Activity During Working Memory: An Endophenotype of Obsessive-Compulsive Disorder. (24365484)
2013
18
Abnormal processing of deontological guilt in obsessive-compulsive disorder. (23681167)
2013
19
Deep brain stimulation in the treatment of obsessive-compulsive disorder. (23044000)
2013
20
Dissociative symptoms and dissociative disorder comorbidity in patients with obsessive-compulsive disorder. (22425531)
2012
21
Cognitive-behavioral therapy for obsessive-compulsive disorder as a comorbidity with schizophrenia or schizoaffective disorder. (22123432)
2012
22
Early sleep psychiatric intervention for acute insomnia: implications from a case of obsessive-compulsive disorder. (22505865)
2012
23
Contextual and behavioral influences on uncertainty in obsessive-compulsive disorder. (23318087)
2012
24
Schizophrenia and obsessive-compulsive disorder: from comorbidity to schizo-obsessive disorder. (22622247)
2012
25
Rage takes center stage: focus on an underappreciated aspect of pediatric obsessive-compulsive disorder. (22632616)
2012
26
Living with parents with obsessive-compulsive disorder: children's lives and experiences. (22903894)
2012
27
Sexual obsessions, compulsions, suicidality and homicidality in an adolescent diagnosed with bipolar disorder not otherwise specified, obsessive-compulsive disorder, pervasive developmental disorder not otherwise specified, and mild mental retardation. (22612525)
2012
28
Quality of life in patients with obsessive compulsive disorder: A longitudinal study from India. (23051114)
2011
29
Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET study. (19660554)
2010
30
Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder. (20565924)
2010
31
Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder. (19578685)
2009
32
Clozapine in treatment-refractory obsessive-compulsive disorder with comorbid schizotypal personality disorder. (19398826)
2008
33
Screening of the epsilon sarcoglycan gene in Tourette syndrome and obsessive compulsive disorder. (18349702)
2008
34
Association study between the dopamine receptor D(4) gene and obsessive-compulsive disorder. (16996722)
2007
35
Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessive- compulsive disorder in a Brazilian sample. (18094849)
2007
36
Rare plus common SERT variants in obsessive-compulsive disorder. (17453059)
2007
37
Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. (15667435)
2005
38
Obsessive-compulsive disorder and body dysmorphic disorder: a comparison of clinical features. (15276662)
2004
39
Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. (15083261)
2004
40
Dopamine transporter density of basal ganglia assessed with [123I]IPT SPET in obsessive-compulsive disorder. (14513291)
2003
41
Obsessive compulsive disorder among idiopathic focal dystonia patients: an epidemiological and family study. (12208643)
2002
42
No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. (10088048)
1999
43
Serotonergic function in social phobia: comparison to normal control and obsessive-compulsive disorder subjects. (9704868)
1998
44
Magnetic resonance brain imaging in women with obsessive-compulsive disorder and trichotillomania. (9255863)
1997
45
Obsessive compulsive symptoms in Gilles de la Tourette syndrome and obsessive compulsive disorder: differences by diagnosis and family history. (9259380)
1997
46
Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. (9114031)
1997
47
DRD2, DRD3 and 5HT2A receptor genes polymorphisms in obsessive-compulsive disorder. (9154247)
1996
48
Fenfluramine stimulation of prolactin in obsessive-compulsive disorder. (1603884)
1992
49
Response of obsessive-compulsive disorder and trichotillomania to serotonin reuptake blockers. (1728180)
1992
50
Prolactin and cortisol responses to MK-212, a serotonin agonist, in obsessive-compulsive disorder. (2203327)
1990

Variations for Obsessive-Compulsive Disorder

About this section

Expression for genes affiliated with Obsessive-Compulsive Disorder

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Obsessive-Compulsive Disorder

Search GEO for disease gene expression data for Obsessive-Compulsive Disorder.

Pathways for genes affiliated with Obsessive-Compulsive Disorder

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 5Cell Signaling Technology, 30KEGG, 53QIAGEN, 51PharmGKB
See all sources

Pathways related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8DRD1, DRD4
2
Show member pathways
Serotonin Transporter Activity38
9.7SLC6A4, MAOA
39.6MAOA, COMT
49.6MAOA, COMT
5
Show member pathways
9.6MAOA, COMT
69.6COMT, MAOA
7
Show member pathways
catecholamine biosynthesis38
9.1MAOA, COMT, TPH1
88.9SLC1A1, HTR1A, HTT, TPH1
9
Show member pathways
8.7HTR2A, HTR1B, HTR1A, DRD4, DRD1
10
Show member pathways
8.7MAOA, PDYN, DRD1, BDNF
11
Show member pathways
8.7MAOA, PDYN, DRD1, BDNF
12
Show member pathways
8.3HTR2A, HTR1B, HTR3A, HTR1A, BDNF
13
Show member pathways
8.1HTR2A, HTR1B, HTR1A, PDYN, DRD4, DRD1
14
Show member pathways
8.1HTR2A, HTR1B, HTR1A, PDYN, DRD4, DRD1
157.4TPH1, HTR2A, HTR3A, HTR1A, MAOA, BDNF
167.4TPH1, HTR2A, HTR1B, HTR3A, HTR1A, MAOA
17
Show member pathways
6.0SLC1A1, TPH1, HTR2A, HTR1B, SLC6A4, DRD1

Compounds for genes affiliated with Obsessive-Compulsive Disorder

About this section
Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 3BitterDB, 61Tocris Bioscience
See all sources

Compounds related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 277)
idCompoundScoreTop Affiliating Genes
1mhpg459.0SLC6A4, DRD4, COMT, MAOA, BDNF
2methylphenidate45 51 1110.8DRD4, DRD1, SLC6A4, COMT, MAOA
3ropinirole45 119.8DRD1, DRD4, COMT, HTR1A, HTR1B, HTR2A
4mcpp458.7HTR1B, HTR1A, HTR2A, SLC6A4, HTR3A
5pergolide45 29 1110.7HTR1B, DRD1, DRD4, COMT, HTR1A, HTR2A
6lisuride45 29 1110.7HTR1B, HTR1A, DRD4, DRD1, HTR2A
7cabergoline45 29 1110.7DRD1, DRD4, COMT, HTR1A, HTR1B, HTR2A
8pindolol45 29 1110.7HTR3A, SLC6A4, HTR1A, HTR1B, HTR2A
9apomorphine29 45 1110.7HTR1A, HTR2A, HTR1B, DRD4, COMT, DRD1
10bromocriptine45 29 1110.6HTR2A, HTR1B, HTR1A, COMT, DRD4, DRD1
11homovanillic acid45 249.5BDNF, MAOA, COMT, TPH1, SLC6A4
12nefazodone45 51 1110.5HTR1A, HTR3A, HTR1B, SLC6A4, HTR2A
13pramipexole45 29 51 1111.5DRD1, DRD4, COMT, HTR1A, HTR1B, BDNF
14spiperone45 299.5DRD1, DRD4, HTR1A, HTR3A, HTR2A
155-hydroxytryptophan458.4HTR1A, HTR2A, TPH1, HTR3A, SLC6A4
16(tfmpp)458.3HTR2A, HTR3A, HTR1A, HTR1B
17fenfluramine45 29 1110.3TPH1, SLC6A4, HTR1A, HTR3A, HTR1B, HTR2A
18aripiprazole29 45 51 24 1112.3HTR2A, HTR1B, HTR3A, DRD4, DRD1, HTR1A
19cocaine45 119.3SLC6A4, DRD4, DRD1, BDNF, COMT, HTR1B
20ziprasidone29 51 45 1111.2HTR1A, HTR1B, HTR3A, DRD4, DRD1, HTR2A
21Serotonin248.2HTR1B, SLC6A4, MAOA, HTR3A, HTR1A, HTR2A
22methysergide45 29 1110.2MAOA, HTR1A, HTR3A, HTR1B, HTR2A
23chlorpromazine29 45 51 1111.2DRD4, HTR2A, HTR3A, HTR1A, DRD1, BDNF
24clomipramine45 51 1110.2SLC6A4, HTR1B, HTR3A, HTR1A, MAOA, HTR2A
25mianserin45 29 1110.2HTR1A, HTR3A, HTR2A, SLC6A4, MAOA
266-hydroxydopamine458.2MAOA, PDYN, DRD4, DRD1, BDNF, COMT
27venlafaxine45 51 24 1111.2HTR2A, BDNF, SLC6A4, COMT, HTR1A, HTR3A
28iloperidone51 45 29 1111.2DRD4, HTR1A, HTR3A, DRD1, HTR2A
29ketanserin45 299.1SLC6A4, BDNF, DRD1, HTR3A, HTR1B, HTR2A
30amphetamine45 51 1110.1DRD4, TPH1, PDYN, SLC6A4, DRD1, MAOA
31haloperidol45 51 29 3 1112.0DRD4, HTR1A, DRD1, BDNF, HTR3A, HTR2A
32imipramine45 29 51 24 1111.9SLC6A4, BDNF, HTR2A, HTR3A, HTR1A, MAOA
33catecholamine457.9MAOA, COMT, PDYN, DRD4, DRD1, BDNF
34citalopram45 51 24 1110.8TPH1, HTR2A, HTR3A, HTR1A, MAOA, BDNF
35quetiapine45 51 29 24 1111.8SLC6A4, HTR1B, HTR2A, HTR3A, HTR1A, BDNF
36maoa457.7COMT, HTR1A, HTR1B, HTR2A, TPH1, MAOA
37methamphetamine45 51 119.7TPH1, COMT, MAOA, PDYN, DRD4, DRD1
38fluoxetine45 51 29 1110.6HTR2A, TPH1, HTR1B, HTR3A, HTR1A, SLC6A4
39fluvoxamine45 51 119.5SLC6A4, BDNF, MAOA, COMT, HTR1A, HTR3A
40olanzapine45 51 29 24 1111.5SLC6A4, BDNF, DRD1, DRD4, COMT, HTR1A
41risperidone45 51 29 61 24 1112.5DRD4, COMT, HTR1A, HTR3A, HTR1B, HTR2A
42clozapine45 29 51 1110.5SLC6A4, BDNF, DRD1, DRD4, HTR2A, HTR1B
43nmda45 298.3SLC6A4, HTR1A, HTT, SLC1A1, BDNF, DRD1
445-hydroxytryptamine457.1TPH1, HTR2A, HTR1B, HTR3A, HTR1A, COMT
45levodopa45 118.1HTR1A, COMT, MAOA, PDYN, DRD4, DRD1
46glutamate457.0MAOA, PDYN, DRD4, BDNF, DRD1, COMT
47gaba456.9BDNF, SLC6A4, SLC1A1, DRD1, DRD4, TPH1
48paroxetine45 51 29 119.9HTR3A, HTR2A, TPH1, HTR1A, COMT, MAOA
49norepinephrine45 24 118.1HTR3A, HTR1A, COMT, MAOA, PDYN, DRD4
50dopamine45 29 24 118.6TPH1, HTR2A, DRD4, DRD1, BDNF, SLC6A4

GO Terms for genes affiliated with Obsessive-Compulsive Disorder

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.2HTT, HTR3A, HTR2A
2integral component of plasma membraneGO:0058876.9SLC6A4, DRD1, DRD4, HTR1A, HTR3A, HTR1B
3plasma membraneGO:0058866.0SLC1A1, HTR2A, SLC6A4, DRD1, DRD4, PDYN

Biological processes related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine secretionGO:01405910.2HTR2A, HTR1B
2L-glutamate importGO:05193810.2SLC1A1, HTT
3negative regulation of synaptic transmission, glutamatergicGO:05196710.2HTR1B, HTR2A
4dopamine receptor signaling pathwayGO:00721210.2HTT, DRD4
5negative regulation of cAMP biosynthetic processGO:03081810.1HTR1B, DRD4
6regulation of hormone secretionGO:04688310.1HTR1A, HTR2A
7social behaviorGO:03517610.0SLC6A4, DRD4, HTT
8adenylate cyclase-inhibiting serotonin receptor signaling pathwayGO:00719810.0HTR1B, HTR1A
9dopamine metabolic processGO:04241710.0DRD1, DRD4
10striatum developmentGO:02175610.0HTT, DRD1
11synaptic transmission, dopaminergicGO:0019639.9DRD4, DRD1
12memoryGO:0076139.9SLC6A4, DRD1, HTR2A
13dopamine catabolic processGO:0424209.9COMT, MAOA
14behavioral response to cocaineGO:0481489.9HTR2A, DRD4, DRD1
15bone remodelingGO:0468499.9TPH1, HTR1B
16neurotransmitter catabolic processGO:0421359.9MAOA, COMT
17grooming behaviorGO:0076259.9HTT, DRD1
18circadian rhythmGO:0076239.8TPH1, DRD4, SLC6A4
19temperature homeostasisGO:0016599.8DRD1, HTR2A
20protein import into nucleusGO:0066069.8DRD1, HTT
21vasoconstrictionGO:0423109.8SLC6A4, HTR1A, HTR1B
22regulation of behaviorGO:0507959.8HTR1A, HTR1B, HTR2A
23neurotransmitter biosynthetic processGO:0421369.7COMT, MAOA
24regulation of dopamine metabolic processGO:0420539.6HTR1A, DRD4, DRD1
25response to drugGO:0424939.5HTR2A, COMT, DRD1, SLC6A4
26response to amphetamineGO:0019759.5DRD1, DRD4
27behavioral fear responseGO:0016629.4HTR1A, DRD4, DRD1, BDNF
28response to cocaineGO:0422209.3HTR1B, HTR3A
29serotonin receptor signaling pathwayGO:0072109.3HTR1A, HTR3A, HTR2A
30synaptic transmissionGO:0072688.6SLC1A1, MAOA, COMT, HTR3A, HTR2A

Molecular functions related to Obsessive-Compulsive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:0352409.8DRD1, DRD4
2dopamine neurotransmitter receptor activityGO:0049529.7DRD1, DRD4
3drug bindingGO:0081449.4HTR2A, DRD4, HTR1B
4serotonin bindingGO:0513789.1HTR2A, HTR1B, HTR3A
5serotonin receptor activityGO:0049938.7HTR1A, HTR3A, HTR1B, HTR2A

Products for genes affiliated with Obsessive-Compulsive Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Obsessive-Compulsive Disorder

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet